-- dump date 20140618_193729 -- class Genbank::misc_feature -- table misc_feature_note -- id note 596153000001 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 596153000002 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 596153000003 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 596153000004 P-loop; other site 596153000005 Magnesium ion binding site [ion binding]; other site 596153000006 H-NS histone family; Region: Histone_HNS; pfam00816 596153000007 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 596153000008 H-NS histone family; Region: Histone_HNS; pfam00816 596153000009 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 596153000010 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 596153000011 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 596153000012 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 596153000013 EAL domain; Region: EAL; pfam00563 596153000014 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 596153000015 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 596153000016 N-acetyl-D-glucosamine binding site [chemical binding]; other site 596153000017 catalytic residue [active] 596153000018 TraL protein; Region: TraL; cl06278 596153000019 TraE protein; Region: TraE; cl05060 596153000020 TraK protein; Region: TraK; pfam06586 596153000021 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 596153000022 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 596153000023 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 596153000024 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 596153000025 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 596153000026 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 596153000027 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 596153000028 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 596153000029 Catalytic site [active] 596153000030 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 596153000031 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 596153000032 TraU protein; Region: TraU; pfam06834 596153000033 conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876 596153000034 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 596153000035 F plasmid transfer operon protein; Region: TraF; pfam13728 596153000036 Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580 596153000037 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 596153000038 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 596153000039 Sel1 repeat; Region: Sel1; cl02723 596153000040 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 596153000041 Cytokine receptor motif; other site 596153000042 transposase/IS protein; Provisional; Region: PRK09183 596153000043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153000044 Walker A motif; other site 596153000045 ATP binding site [chemical binding]; other site 596153000046 Walker B motif; other site 596153000047 arginine finger; other site 596153000048 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 596153000049 Integrase core domain; Region: rve; pfam00665 596153000050 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 596153000051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 596153000052 non-specific DNA binding site [nucleotide binding]; other site 596153000053 salt bridge; other site 596153000054 sequence-specific DNA binding site [nucleotide binding]; other site 596153000055 Integrase core domain; Region: rve; pfam00665 596153000056 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 596153000057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153000058 Walker A motif; other site 596153000059 ATP binding site [chemical binding]; other site 596153000060 Walker B motif; other site 596153000061 arginine finger; other site 596153000062 ParB-like nuclease domain; Region: ParBc; cl02129 596153000063 KorB domain; Region: KorB; pfam08535 596153000064 Allene oxide cyclase; Region: Allene_ox_cyc; cl05704 596153000065 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 596153000066 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 596153000067 active site 596153000068 Int/Topo IB signature motif; other site 596153000069 catalytic residues [active] 596153000070 DNA binding site [nucleotide binding] 596153000071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 596153000072 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 596153000073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 596153000074 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 596153000075 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 596153000076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 596153000077 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 596153000078 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 596153000079 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 596153000080 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 596153000081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 596153000082 Transposase; Region: HTH_Tnp_1; pfam01527 596153000083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153000084 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 596153000085 PLD-like domain; Region: PLDc_2; pfam13091 596153000086 putative active site [active] 596153000087 catalytic site [active] 596153000088 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 596153000089 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 596153000090 tandem repeat interface [polypeptide binding]; other site 596153000091 oligomer interface [polypeptide binding]; other site 596153000092 active site residues [active] 596153000093 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 596153000094 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 596153000095 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 596153000096 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 596153000097 Chlorite dismutase; Region: Chlor_dismutase; cl01280 596153000098 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 596153000099 HPP family; Region: HPP; pfam04982 596153000100 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 596153000101 Walker A motif; other site 596153000102 Cytochrome c; Region: Cytochrom_C; cl11414 596153000103 Heme-binding domain of bacterial ethylbenzene dehydrogenase; Region: DOMON_EBDH; cd09623 596153000104 beta subunit binding site [polypeptide binding]; other site 596153000105 heme binding site [chemical binding]; other site 596153000106 DMSO reductase family type II enzyme chaperone; Region: DMSO_red_II_cha; TIGR03482 596153000107 DMSO reductase family type II enzyme, iron-sulfur subunit; Region: DMSO_red_II_bet; TIGR03478 596153000108 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 596153000109 DMSO reductase family type II enzyme, molybdopterin subunit; Region: DMSO_red_II_alp; TIGR03479 596153000110 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 596153000111 [4Fe-4S] binding site [ion binding]; other site 596153000112 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 596153000113 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 596153000114 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 596153000115 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 596153000116 molybdopterin cofactor binding site; other site 596153000117 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 596153000118 pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953 596153000119 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 596153000120 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 596153000121 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 596153000122 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 596153000123 active site 596153000124 DNA binding site [nucleotide binding] 596153000125 Int/Topo IB signature motif; other site 596153000126 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 596153000127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153000128 Walker A motif; other site 596153000129 ATP binding site [chemical binding]; other site 596153000130 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 596153000131 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 596153000132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 596153000133 Integrase core domain; Region: rve; pfam00665 596153000134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 596153000135 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 596153000136 Phage integrase protein; Region: DUF3701; pfam12482 596153000137 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 596153000138 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 596153000139 active site 596153000140 DNA binding site [nucleotide binding] 596153000141 Int/Topo IB signature motif; other site 596153000142 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 596153000143 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 596153000144 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 596153000145 DNA methylase; Region: N6_N4_Mtase; pfam01555 596153000146 DNA methylase; Region: N6_N4_Mtase; pfam01555 596153000147 PemK-like protein; Region: PemK; pfam02452 596153000148 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 596153000149 Restriction endonuclease; Region: Mrr_cat; pfam04471 596153000150 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 596153000151 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 596153000152 IHF dimer interface [polypeptide binding]; other site 596153000153 IHF - DNA interface [nucleotide binding]; other site 596153000154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 596153000155 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 596153000156 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 596153000157 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 596153000158 Chlorite dismutase; Region: Chlor_dismutase; cl01280 596153000159 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 596153000160 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 596153000161 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 596153000162 catalytic residues [active] 596153000163 catalytic nucleophile [active] 596153000164 Presynaptic Site I dimer interface [polypeptide binding]; other site 596153000165 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 596153000166 Synaptic Flat tetramer interface [polypeptide binding]; other site 596153000167 Synaptic Site I dimer interface [polypeptide binding]; other site 596153000168 DNA binding site [nucleotide binding] 596153000169 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 596153000170 DNA-binding interface [nucleotide binding]; DNA binding site 596153000171 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 596153000172 WGR domain; Region: WGR; cl01581 596153000173 Initiator Replication protein; Region: Rep_3; pfam01051 596153000174 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 596153000175 DnaA N-terminal domain; Region: DnaA_N; pfam11638 596153000176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153000177 Walker A motif; other site 596153000178 ATP binding site [chemical binding]; other site 596153000179 Walker B motif; other site 596153000180 arginine finger; other site 596153000181 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 596153000182 DnaA box-binding interface [nucleotide binding]; other site 596153000183 DNA polymerase III subunit beta; Validated; Region: PRK05643 596153000184 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 596153000185 putative DNA binding surface [nucleotide binding]; other site 596153000186 dimer interface [polypeptide binding]; other site 596153000187 beta-clamp/clamp loader binding surface; other site 596153000188 beta-clamp/translesion DNA polymerase binding surface; other site 596153000189 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 596153000190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153000191 ATP binding site [chemical binding]; other site 596153000192 Mg2+ binding site [ion binding]; other site 596153000193 G-X-G motif; other site 596153000194 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 596153000195 anchoring element; other site 596153000196 dimer interface [polypeptide binding]; other site 596153000197 ATP binding site [chemical binding]; other site 596153000198 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 596153000199 active site 596153000200 putative metal-binding site [ion binding]; other site 596153000201 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 596153000202 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 596153000203 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153000204 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153000205 enoyl-CoA hydratase; Provisional; Region: PRK05995 596153000206 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153000207 substrate binding site [chemical binding]; other site 596153000208 oxyanion hole (OAH) forming residues; other site 596153000209 trimer interface [polypeptide binding]; other site 596153000210 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153000211 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153000212 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153000213 dimerization interface [polypeptide binding]; other site 596153000214 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000215 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 596153000216 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 596153000217 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 596153000218 ATP-grasp domain; Region: ATP-grasp_4; cl17255 596153000219 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 596153000220 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 596153000221 carboxyltransferase (CT) interaction site; other site 596153000222 biotinylation site [posttranslational modification]; other site 596153000223 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153000224 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153000225 active site 596153000226 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 596153000227 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 596153000228 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 596153000229 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 596153000230 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 596153000231 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 596153000232 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 596153000233 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 596153000234 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 596153000235 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 596153000236 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 596153000237 active site 596153000238 catalytic site [active] 596153000239 substrate binding site [chemical binding]; other site 596153000240 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 596153000241 NlpC/P60 family; Region: NLPC_P60; pfam00877 596153000242 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 596153000243 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 596153000244 GAF domain; Region: GAF_3; pfam13492 596153000245 PAS domain S-box; Region: sensory_box; TIGR00229 596153000246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153000247 putative active site [active] 596153000248 heme pocket [chemical binding]; other site 596153000249 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 596153000250 GAF domain; Region: GAF; pfam01590 596153000251 PAS domain S-box; Region: sensory_box; TIGR00229 596153000252 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153000253 putative active site [active] 596153000254 heme pocket [chemical binding]; other site 596153000255 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153000256 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153000257 metal binding site [ion binding]; metal-binding site 596153000258 active site 596153000259 I-site; other site 596153000260 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 596153000261 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 596153000262 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153000263 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153000264 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000265 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153000266 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 596153000267 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153000268 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153000269 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 596153000270 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 596153000271 FAD binding site [chemical binding]; other site 596153000272 substrate binding site [chemical binding]; other site 596153000273 catalytic base [active] 596153000274 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000275 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 596153000276 CoA binding domain; Region: CoA_binding_2; pfam13380 596153000277 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 596153000278 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 596153000279 enoyl-CoA hydratase; Provisional; Region: PRK08290 596153000280 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153000281 substrate binding site [chemical binding]; other site 596153000282 oxyanion hole (OAH) forming residues; other site 596153000283 trimer interface [polypeptide binding]; other site 596153000284 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153000285 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 596153000286 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 596153000287 LTXXQ motif family protein; Region: LTXXQ; pfam07813 596153000288 recombination associated protein; Reviewed; Region: rdgC; PRK00321 596153000289 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 596153000290 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 596153000291 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 596153000292 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 596153000293 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 596153000294 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 596153000295 DNA binding residues [nucleotide binding] 596153000296 dimer interface [polypeptide binding]; other site 596153000297 copper binding site [ion binding]; other site 596153000298 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 596153000299 metal-binding site [ion binding] 596153000300 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 596153000301 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 596153000302 metal-binding site [ion binding] 596153000303 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 596153000304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 596153000305 motif II; other site 596153000306 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 596153000307 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 596153000308 dimerization interface [polypeptide binding]; other site 596153000309 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 596153000310 dimer interface [polypeptide binding]; other site 596153000311 putative CheW interface [polypeptide binding]; other site 596153000312 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 596153000313 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 596153000314 HlyD family secretion protein; Region: HlyD_3; pfam13437 596153000315 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 596153000316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153000317 active site 596153000318 phosphorylation site [posttranslational modification] 596153000319 intermolecular recognition site; other site 596153000320 dimerization interface [polypeptide binding]; other site 596153000321 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 596153000322 DNA binding site [nucleotide binding] 596153000323 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 596153000324 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 596153000325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153000326 dimer interface [polypeptide binding]; other site 596153000327 phosphorylation site [posttranslational modification] 596153000328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153000329 ATP binding site [chemical binding]; other site 596153000330 Mg2+ binding site [ion binding]; other site 596153000331 G-X-G motif; other site 596153000332 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 596153000333 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 596153000334 FMN binding site [chemical binding]; other site 596153000335 active site 596153000336 substrate binding site [chemical binding]; other site 596153000337 catalytic residue [active] 596153000338 glutathionine S-transferase; Provisional; Region: PRK10542 596153000339 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 596153000340 C-terminal domain interface [polypeptide binding]; other site 596153000341 GSH binding site (G-site) [chemical binding]; other site 596153000342 dimer interface [polypeptide binding]; other site 596153000343 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 596153000344 dimer interface [polypeptide binding]; other site 596153000345 N-terminal domain interface [polypeptide binding]; other site 596153000346 substrate binding pocket (H-site) [chemical binding]; other site 596153000347 Predicted flavoprotein [General function prediction only]; Region: COG0431 596153000348 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 596153000349 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 596153000350 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 596153000351 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 596153000352 DNA polymerase IV; Provisional; Region: PRK02794 596153000353 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 596153000354 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 596153000355 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 596153000356 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 596153000357 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 596153000358 P-loop; other site 596153000359 Magnesium ion binding site [ion binding]; other site 596153000360 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 596153000361 Magnesium ion binding site [ion binding]; other site 596153000362 Serine hydrolase; Region: Ser_hydrolase; pfam06821 596153000363 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 596153000364 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 596153000365 ParB-like nuclease domain; Region: ParB; smart00470 596153000366 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 596153000367 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 596153000368 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 596153000369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153000370 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 596153000371 Mechanosensitive ion channel; Region: MS_channel; pfam00924 596153000372 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 596153000373 FAD binding domain; Region: FAD_binding_4; pfam01565 596153000374 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 596153000375 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 596153000376 Protein of unknown function (DUF935); Region: DUF935; pfam06074 596153000377 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 596153000378 Helix-turn-helix domain; Region: HTH_17; cl17695 596153000379 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 596153000380 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 596153000381 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 596153000382 CoenzymeA binding site [chemical binding]; other site 596153000383 subunit interaction site [polypeptide binding]; other site 596153000384 PHB binding site; other site 596153000385 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 596153000386 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 596153000387 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 596153000388 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 596153000389 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153000390 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153000391 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153000392 dimerization interface [polypeptide binding]; other site 596153000393 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000394 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 596153000395 classical (c) SDRs; Region: SDR_c; cd05233 596153000396 NAD(P) binding site [chemical binding]; other site 596153000397 active site 596153000398 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 596153000399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153000400 NAD(P) binding site [chemical binding]; other site 596153000401 active site 596153000402 Uncharacterized conserved protein [Function unknown]; Region: COG2128 596153000403 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 596153000404 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 596153000405 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 596153000406 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 596153000407 hypothetical protein; Provisional; Region: PRK09126 596153000408 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 596153000409 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 596153000410 acyl-activating enzyme (AAE) consensus motif; other site 596153000411 putative AMP binding site [chemical binding]; other site 596153000412 putative active site [active] 596153000413 putative CoA binding site [chemical binding]; other site 596153000414 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153000415 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153000416 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 596153000417 dimerization interface [polypeptide binding]; other site 596153000418 substrate binding pocket [chemical binding]; other site 596153000419 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000420 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153000421 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153000422 active site 596153000423 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153000424 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153000425 enoyl-CoA hydratase; Provisional; Region: PRK09245 596153000426 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153000427 substrate binding site [chemical binding]; other site 596153000428 oxyanion hole (OAH) forming residues; other site 596153000429 trimer interface [polypeptide binding]; other site 596153000430 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 596153000431 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 596153000432 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 596153000433 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 596153000434 N-terminal plug; other site 596153000435 ligand-binding site [chemical binding]; other site 596153000436 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 596153000437 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 596153000438 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 596153000439 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 596153000440 septum formation inhibitor; Reviewed; Region: PRK01973 596153000441 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 596153000442 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 596153000443 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 596153000444 Switch I; other site 596153000445 Switch II; other site 596153000446 cell division topological specificity factor MinE; Provisional; Region: PRK13989 596153000447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153000448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153000449 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 596153000450 putative effector binding pocket; other site 596153000451 putative dimerization interface [polypeptide binding]; other site 596153000452 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000453 galactonate dehydratase; Provisional; Region: PRK14017 596153000454 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 596153000455 active site pocket [active] 596153000456 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 596153000457 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 596153000458 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 596153000459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 596153000460 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 596153000461 Ligand Binding Site [chemical binding]; other site 596153000462 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 596153000463 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 596153000464 active site 596153000465 metal binding site [ion binding]; metal-binding site 596153000466 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153000467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153000468 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 596153000469 substrate binding pocket [chemical binding]; other site 596153000470 dimerization interface [polypeptide binding]; other site 596153000471 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 596153000472 active site 596153000473 substrate-binding site [chemical binding]; other site 596153000474 metal-binding site [ion binding] 596153000475 GTP binding site [chemical binding]; other site 596153000476 threonine dehydratase; Provisional; Region: PRK07334 596153000477 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 596153000478 tetramer interface [polypeptide binding]; other site 596153000479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153000480 catalytic residue [active] 596153000481 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 596153000482 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 596153000483 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153000484 active site 596153000485 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 596153000486 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 596153000487 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 596153000488 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 596153000489 Soluble P-type ATPase [General function prediction only]; Region: COG4087 596153000490 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 596153000491 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 596153000492 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 596153000493 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 596153000494 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153000495 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 596153000496 putative dimerization interface [polypeptide binding]; other site 596153000497 putative substrate binding pocket [chemical binding]; other site 596153000498 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153000499 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153000500 active site 596153000501 Cupin domain; Region: Cupin_2; pfam07883 596153000502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153000503 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 596153000504 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 596153000505 ATP binding site [chemical binding]; other site 596153000506 putative Mg++ binding site [ion binding]; other site 596153000507 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 596153000508 nucleotide binding region [chemical binding]; other site 596153000509 ATP-binding site [chemical binding]; other site 596153000510 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 596153000511 HRDC domain; Region: HRDC; pfam00570 596153000512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 596153000513 FeS/SAM binding site; other site 596153000514 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 596153000515 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 596153000516 ATP cone domain; Region: ATP-cone; pfam03477 596153000517 Class III ribonucleotide reductase; Region: RNR_III; cd01675 596153000518 effector binding site; other site 596153000519 active site 596153000520 Zn binding site [ion binding]; other site 596153000521 PAS fold; Region: PAS_4; pfam08448 596153000522 PAS domain; Region: PAS_9; pfam13426 596153000523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153000524 putative active site [active] 596153000525 heme pocket [chemical binding]; other site 596153000526 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153000527 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153000528 metal binding site [ion binding]; metal-binding site 596153000529 active site 596153000530 I-site; other site 596153000531 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 596153000532 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 596153000533 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 596153000534 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 596153000535 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 596153000536 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 596153000537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153000538 Walker A motif; other site 596153000539 ATP binding site [chemical binding]; other site 596153000540 Walker B motif; other site 596153000541 arginine finger; other site 596153000542 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 596153000543 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 596153000544 heme-binding site [chemical binding]; other site 596153000545 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 596153000546 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 596153000547 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 596153000548 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000549 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 596153000550 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153000551 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 596153000552 acyl-activating enzyme (AAE) consensus motif; other site 596153000553 acyl-activating enzyme (AAE) consensus motif; other site 596153000554 putative AMP binding site [chemical binding]; other site 596153000555 putative active site [active] 596153000556 putative CoA binding site [chemical binding]; other site 596153000557 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000558 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 596153000559 CoenzymeA binding site [chemical binding]; other site 596153000560 subunit interaction site [polypeptide binding]; other site 596153000561 PHB binding site; other site 596153000562 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000563 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000564 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153000565 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153000566 active site 596153000567 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153000568 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 596153000569 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 596153000570 acyl-activating enzyme (AAE) consensus motif; other site 596153000571 acyl-activating enzyme (AAE) consensus motif; other site 596153000572 putative AMP binding site [chemical binding]; other site 596153000573 putative active site [active] 596153000574 putative CoA binding site [chemical binding]; other site 596153000575 CoA binding site [chemical binding]; other site 596153000576 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 596153000577 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 596153000578 dimer interface [polypeptide binding]; other site 596153000579 active site 596153000580 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 596153000581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153000582 NAD(P) binding site [chemical binding]; other site 596153000583 active site 596153000584 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000585 short chain dehydrogenase; Provisional; Region: PRK07576 596153000586 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 596153000587 NAD(P) binding site [chemical binding]; other site 596153000588 substrate binding site [chemical binding]; other site 596153000589 homotetramer interface [polypeptide binding]; other site 596153000590 active site 596153000591 homodimer interface [polypeptide binding]; other site 596153000592 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 596153000593 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153000594 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153000595 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153000596 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153000597 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000598 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 596153000599 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 596153000600 DUF35 OB-fold domain; Region: DUF35; pfam01796 596153000601 thiolase; Provisional; Region: PRK06158 596153000602 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 596153000603 active site 596153000604 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153000605 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153000606 active site 596153000607 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153000608 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 596153000609 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 596153000610 acyl-activating enzyme (AAE) consensus motif; other site 596153000611 acyl-activating enzyme (AAE) consensus motif; other site 596153000612 putative AMP binding site [chemical binding]; other site 596153000613 putative active site [active] 596153000614 putative CoA binding site [chemical binding]; other site 596153000615 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 596153000616 enoyl-CoA hydratase; Region: PLN02864 596153000617 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 596153000618 dimer interaction site [polypeptide binding]; other site 596153000619 substrate-binding tunnel; other site 596153000620 active site 596153000621 catalytic site [active] 596153000622 substrate binding site [chemical binding]; other site 596153000623 short chain dehydrogenase; Provisional; Region: PRK07791 596153000624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153000625 NAD(P) binding site [chemical binding]; other site 596153000626 active site 596153000627 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000628 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 596153000629 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 596153000630 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153000631 Major Facilitator Superfamily; Region: MFS_1; pfam07690 596153000632 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 596153000633 Transposase domain (DUF772); Region: DUF772; pfam05598 596153000634 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 596153000635 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 596153000636 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 596153000637 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153000638 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153000639 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153000640 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153000641 active site 596153000642 Uncharacterized conserved protein [Function unknown]; Region: COG3777 596153000643 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 596153000644 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 596153000645 active site 2 [active] 596153000646 active site 1 [active] 596153000647 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 596153000648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153000649 NAD(P) binding site [chemical binding]; other site 596153000650 active site 596153000651 enoyl-CoA hydratase; Region: PLN02864 596153000652 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 596153000653 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 596153000654 dimer interaction site [polypeptide binding]; other site 596153000655 substrate-binding tunnel; other site 596153000656 active site 596153000657 catalytic site [active] 596153000658 substrate binding site [chemical binding]; other site 596153000659 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 596153000660 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153000661 substrate binding site [chemical binding]; other site 596153000662 oxyanion hole (OAH) forming residues; other site 596153000663 trimer interface [polypeptide binding]; other site 596153000664 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 596153000665 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 596153000666 Coenzyme A transferase; Region: CoA_trans; cl17247 596153000667 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 596153000668 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 596153000669 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 596153000670 dimer interface [polypeptide binding]; other site 596153000671 active site 596153000672 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153000673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153000674 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 596153000675 putative effector binding pocket; other site 596153000676 dimerization interface [polypeptide binding]; other site 596153000677 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153000678 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153000679 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 596153000680 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 596153000681 NAD(P) binding site [chemical binding]; other site 596153000682 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000683 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 596153000684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153000685 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 596153000686 dimerization interface [polypeptide binding]; other site 596153000687 substrate binding pocket [chemical binding]; other site 596153000688 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000689 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 596153000690 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 596153000691 metal binding site [ion binding]; metal-binding site 596153000692 putative dimer interface [polypeptide binding]; other site 596153000693 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000694 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 596153000695 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153000696 acyl-activating enzyme (AAE) consensus motif; other site 596153000697 AMP binding site [chemical binding]; other site 596153000698 active site 596153000699 CoA binding site [chemical binding]; other site 596153000700 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000701 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000702 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 596153000703 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 596153000704 metal binding site [ion binding]; metal-binding site 596153000705 putative dimer interface [polypeptide binding]; other site 596153000706 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 596153000707 DUF35 OB-fold domain; Region: DUF35; pfam01796 596153000708 thiolase; Provisional; Region: PRK06158 596153000709 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 596153000710 active site 596153000711 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153000712 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153000713 active site 596153000714 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 596153000715 CoenzymeA binding site [chemical binding]; other site 596153000716 subunit interaction site [polypeptide binding]; other site 596153000717 PHB binding site; other site 596153000718 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153000719 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 596153000720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153000721 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 596153000722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153000723 NAD(P) binding site [chemical binding]; other site 596153000724 active site 596153000725 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153000726 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153000727 active site 596153000728 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 596153000729 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153000730 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153000731 active site 596153000732 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153000733 enoyl-CoA hydratase; Provisional; Region: PRK07468 596153000734 substrate binding site [chemical binding]; other site 596153000735 oxyanion hole (OAH) forming residues; other site 596153000736 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 596153000737 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 596153000738 ATP-grasp domain; Region: ATP-grasp_4; cl17255 596153000739 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 596153000740 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 596153000741 carboxyltransferase (CT) interaction site; other site 596153000742 biotinylation site [posttranslational modification]; other site 596153000743 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 596153000744 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000745 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153000746 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153000747 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153000748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153000749 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 596153000750 putative dimerization interface [polypeptide binding]; other site 596153000751 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153000752 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153000753 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153000754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153000755 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 596153000756 putative dimerization interface [polypeptide binding]; other site 596153000757 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000758 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153000759 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153000760 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 596153000761 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 596153000762 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 596153000763 NAD(P) binding site [chemical binding]; other site 596153000764 Predicted membrane protein [Function unknown]; Region: COG4125 596153000765 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 596153000766 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 596153000767 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 596153000768 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 596153000769 substrate binding pocket [chemical binding]; other site 596153000770 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 596153000771 B12 binding site [chemical binding]; other site 596153000772 cobalt ligand [ion binding]; other site 596153000773 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 596153000774 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 596153000775 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 596153000776 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 596153000777 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 596153000778 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 596153000779 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 596153000780 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 596153000781 VirB7 interaction site; other site 596153000782 conjugal transfer protein TrbF; Provisional; Region: PRK13872 596153000783 conjugal transfer protein TrbL; Provisional; Region: PRK13875 596153000784 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 596153000785 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 596153000786 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 596153000787 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 596153000788 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 596153000789 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 596153000790 Walker A motif; other site 596153000791 ATP binding site [chemical binding]; other site 596153000792 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 596153000793 Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268 596153000794 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 596153000795 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 596153000796 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 596153000797 ATP binding site [chemical binding]; other site 596153000798 Walker A motif; other site 596153000799 hexamer interface [polypeptide binding]; other site 596153000800 Walker B motif; other site 596153000801 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 596153000802 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 596153000803 Walker A motif; other site 596153000804 ATP binding site [chemical binding]; other site 596153000805 Walker B motif; other site 596153000806 conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360 596153000807 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 596153000808 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153000809 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 596153000810 dimerization interface [polypeptide binding]; other site 596153000811 substrate binding pocket [chemical binding]; other site 596153000812 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 596153000813 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 596153000814 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 596153000815 HlyD family secretion protein; Region: HlyD_3; pfam13437 596153000816 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 596153000817 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 596153000818 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 596153000819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153000820 active site 596153000821 phosphorylation site [posttranslational modification] 596153000822 intermolecular recognition site; other site 596153000823 dimerization interface [polypeptide binding]; other site 596153000824 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 596153000825 DNA binding site [nucleotide binding] 596153000826 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 596153000827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153000828 dimer interface [polypeptide binding]; other site 596153000829 phosphorylation site [posttranslational modification] 596153000830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153000831 ATP binding site [chemical binding]; other site 596153000832 Mg2+ binding site [ion binding]; other site 596153000833 G-X-G motif; other site 596153000834 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 596153000835 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 596153000836 Double zinc ribbon; Region: DZR; pfam12773 596153000837 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 596153000838 metal-binding site [ion binding] 596153000839 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 596153000840 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 596153000841 metal-binding site [ion binding] 596153000842 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 596153000843 Soluble P-type ATPase [General function prediction only]; Region: COG4087 596153000844 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 596153000845 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 596153000846 DNA binding residues [nucleotide binding] 596153000847 dimer interface [polypeptide binding]; other site 596153000848 putative metal binding site [ion binding]; other site 596153000849 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 596153000850 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 596153000851 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 596153000852 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 596153000853 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 596153000854 ParA-like protein; Provisional; Region: PHA02518 596153000855 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 596153000856 P-loop; other site 596153000857 Magnesium ion binding site [ion binding]; other site 596153000858 Replication initiator protein A; Region: RPA; pfam10134 596153000859 Helix-turn-helix domain; Region: HTH_17; cl17695 596153000860 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 596153000861 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 596153000862 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 596153000863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 596153000864 non-specific DNA binding site [nucleotide binding]; other site 596153000865 salt bridge; other site 596153000866 sequence-specific DNA binding site [nucleotide binding]; other site 596153000867 Uncharacterized conserved protein [Function unknown]; Region: COG5489 596153000868 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 596153000869 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 596153000870 synthetase active site [active] 596153000871 NTP binding site [chemical binding]; other site 596153000872 metal binding site [ion binding]; metal-binding site 596153000873 ParB-like nuclease domain; Region: ParBc; pfam02195 596153000874 Domain of unknown function (DUF932); Region: DUF932; pfam06067 596153000875 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 596153000876 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 596153000877 non-specific DNA binding site [nucleotide binding]; other site 596153000878 salt bridge; other site 596153000879 sequence-specific DNA binding site [nucleotide binding]; other site 596153000880 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 596153000881 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 596153000882 putative active site [active] 596153000883 putative NTP binding site [chemical binding]; other site 596153000884 putative nucleic acid binding site [nucleotide binding]; other site 596153000885 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 596153000886 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 596153000887 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 596153000888 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 596153000889 active site 596153000890 DNA binding site [nucleotide binding] 596153000891 Int/Topo IB signature motif; other site 596153000892 shikimate kinase; Reviewed; Region: aroK; PRK00131 596153000893 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 596153000894 ADP binding site [chemical binding]; other site 596153000895 magnesium binding site [ion binding]; other site 596153000896 putative shikimate binding site; other site 596153000897 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 596153000898 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 596153000899 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 596153000900 FAD binding pocket [chemical binding]; other site 596153000901 FAD binding motif [chemical binding]; other site 596153000902 phosphate binding motif [ion binding]; other site 596153000903 beta-alpha-beta structure motif; other site 596153000904 NAD binding pocket [chemical binding]; other site 596153000905 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 596153000906 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153000907 putative ligand binding site [chemical binding]; other site 596153000908 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 596153000909 TM-ABC transporter signature motif; other site 596153000910 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 596153000911 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 596153000912 TM-ABC transporter signature motif; other site 596153000913 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 596153000914 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 596153000915 Walker A/P-loop; other site 596153000916 ATP binding site [chemical binding]; other site 596153000917 Q-loop/lid; other site 596153000918 ABC transporter signature motif; other site 596153000919 Walker B; other site 596153000920 D-loop; other site 596153000921 H-loop/switch region; other site 596153000922 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 596153000923 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 596153000924 Walker A/P-loop; other site 596153000925 ATP binding site [chemical binding]; other site 596153000926 Q-loop/lid; other site 596153000927 ABC transporter signature motif; other site 596153000928 Walker B; other site 596153000929 D-loop; other site 596153000930 H-loop/switch region; other site 596153000931 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 596153000932 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 596153000933 active site 596153000934 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 596153000935 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 596153000936 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 596153000937 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 596153000938 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 596153000939 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 596153000940 Nitrogen regulatory protein P-II; Region: P-II; smart00938 596153000941 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 596153000942 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 596153000943 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153000944 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 596153000945 dimerization interface [polypeptide binding]; other site 596153000946 substrate binding pocket [chemical binding]; other site 596153000947 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 596153000948 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 596153000949 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 596153000950 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 596153000951 tetramerization interface [polypeptide binding]; other site 596153000952 NAD(P) binding site [chemical binding]; other site 596153000953 catalytic residues [active] 596153000954 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000955 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 596153000956 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153000957 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 596153000958 putative ligand binding site [chemical binding]; other site 596153000959 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 596153000960 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 596153000961 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 596153000962 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 596153000963 SCP-2 sterol transfer family; Region: SCP2; cl01225 596153000964 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 596153000965 Putative ammonia monooxygenase; Region: AmoA; pfam05145 596153000966 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 596153000967 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 596153000968 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153000969 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 596153000970 active site 596153000971 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153000972 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 596153000973 CoA binding domain; Region: CoA_binding_2; pfam13380 596153000974 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 596153000975 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 596153000976 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 596153000977 FAD binding domain; Region: FAD_binding_4; pfam01565 596153000978 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 596153000979 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 596153000980 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 596153000981 Cysteine-rich domain; Region: CCG; pfam02754 596153000982 Cysteine-rich domain; Region: CCG; pfam02754 596153000983 ProQ/FINO family; Region: ProQ; smart00945 596153000984 putative RNA binding sites [nucleotide binding]; other site 596153000985 EamA-like transporter family; Region: EamA; pfam00892 596153000986 lysophospholipid transporter LplT; Provisional; Region: PRK11195 596153000987 alanine racemase; Reviewed; Region: dadX; PRK03646 596153000988 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 596153000989 active site 596153000990 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 596153000991 substrate binding site [chemical binding]; other site 596153000992 catalytic residues [active] 596153000993 dimer interface [polypeptide binding]; other site 596153000994 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 596153000995 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 596153000996 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 596153000997 C-terminal domain interface [polypeptide binding]; other site 596153000998 GSH binding site (G-site) [chemical binding]; other site 596153000999 dimer interface [polypeptide binding]; other site 596153001000 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 596153001001 dimer interface [polypeptide binding]; other site 596153001002 N-terminal domain interface [polypeptide binding]; other site 596153001003 substrate binding pocket (H-site) [chemical binding]; other site 596153001004 DNA repair protein RadA; Provisional; Region: PRK11823 596153001005 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 596153001006 Walker A motif/ATP binding site; other site 596153001007 ATP binding site [chemical binding]; other site 596153001008 Walker B motif; other site 596153001009 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 596153001010 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153001011 putative amidase; Provisional; Region: PRK06169 596153001012 Amidase; Region: Amidase; pfam01425 596153001013 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 596153001014 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 596153001015 homodimer interface [polypeptide binding]; other site 596153001016 substrate-cofactor binding pocket; other site 596153001017 catalytic residue [active] 596153001018 Zinc-finger domain; Region: zf-CHCC; cl01821 596153001019 O-Antigen ligase; Region: Wzy_C; pfam04932 596153001020 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 596153001021 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 596153001022 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 596153001023 putative ADP-binding pocket [chemical binding]; other site 596153001024 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 596153001025 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 596153001026 active site 596153001027 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 596153001028 Nitronate monooxygenase; Region: NMO; pfam03060 596153001029 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 596153001030 FMN binding site [chemical binding]; other site 596153001031 substrate binding site [chemical binding]; other site 596153001032 putative catalytic residue [active] 596153001033 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153001034 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153001035 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153001036 dimerization interface [polypeptide binding]; other site 596153001037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153001038 putative substrate translocation pore; other site 596153001039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 596153001040 MOSC domain; Region: MOSC; pfam03473 596153001041 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 596153001042 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 596153001043 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 596153001044 putative hydrophobic ligand binding site [chemical binding]; other site 596153001045 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 596153001046 active site 596153001047 catalytic site [active] 596153001048 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153001049 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153001050 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153001051 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153001052 dimerization interface [polypeptide binding]; other site 596153001053 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153001054 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153001055 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 596153001056 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 596153001057 dimerization interface [polypeptide binding]; other site 596153001058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153001059 dimer interface [polypeptide binding]; other site 596153001060 phosphorylation site [posttranslational modification] 596153001061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153001062 ATP binding site [chemical binding]; other site 596153001063 Mg2+ binding site [ion binding]; other site 596153001064 G-X-G motif; other site 596153001065 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 596153001066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153001067 active site 596153001068 phosphorylation site [posttranslational modification] 596153001069 intermolecular recognition site; other site 596153001070 dimerization interface [polypeptide binding]; other site 596153001071 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 596153001072 DNA binding site [nucleotide binding] 596153001073 AmpG-like permease; Region: 2A0125; TIGR00901 596153001074 Cupin domain; Region: Cupin_2; cl17218 596153001075 Peptidase family M48; Region: Peptidase_M48; pfam01435 596153001076 Transcriptional regulators [Transcription]; Region: GntR; COG1802 596153001077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153001078 DNA-binding site [nucleotide binding]; DNA binding site 596153001079 FCD domain; Region: FCD; pfam07729 596153001080 Activator of aromatic catabolism; Region: XylR_N; pfam06505 596153001081 V4R domain; Region: V4R; pfam02830 596153001082 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 596153001083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153001084 Walker A motif; other site 596153001085 ATP binding site [chemical binding]; other site 596153001086 Walker B motif; other site 596153001087 arginine finger; other site 596153001088 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 596153001089 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 596153001090 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 596153001091 dimerization interface [polypeptide binding]; other site 596153001092 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 596153001093 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 596153001094 dimerization interface [polypeptide binding]; other site 596153001095 putative path to active site cavity [active] 596153001096 diiron center [ion binding]; other site 596153001097 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 596153001098 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 596153001099 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 596153001100 catalytic loop [active] 596153001101 iron binding site [ion binding]; other site 596153001102 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211 596153001103 FAD binding pocket [chemical binding]; other site 596153001104 FAD binding motif [chemical binding]; other site 596153001105 phosphate binding motif [ion binding]; other site 596153001106 beta-alpha-beta structure motif; other site 596153001107 NAD binding pocket [chemical binding]; other site 596153001108 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 596153001109 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 596153001110 catalytic loop [active] 596153001111 iron binding site [ion binding]; other site 596153001112 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 596153001113 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 596153001114 tetramer interface [polypeptide binding]; other site 596153001115 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 596153001116 active site 596153001117 metal binding site [ion binding]; metal-binding site 596153001118 Domain of unknown function (DUF336); Region: DUF336; pfam03928 596153001119 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 596153001120 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 596153001121 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 596153001122 NAD binding site [chemical binding]; other site 596153001123 catalytic residues [active] 596153001124 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 596153001125 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 596153001126 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 596153001127 acetaldehyde dehydrogenase; Validated; Region: PRK08300 596153001128 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 596153001129 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 596153001130 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 596153001131 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 596153001132 active site 596153001133 catalytic residues [active] 596153001134 metal binding site [ion binding]; metal-binding site 596153001135 DmpG-like communication domain; Region: DmpG_comm; pfam07836 596153001136 4-oxalocrotonate decarboxylase; Region: catechol_dmpH; TIGR03218 596153001137 Tripartite tricarboxylate transporter family receptor; Region: TctC; pfam03401 596153001138 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 596153001139 active site 1 [active] 596153001140 dimer interface [polypeptide binding]; other site 596153001141 hexamer interface [polypeptide binding]; other site 596153001142 active site 2 [active] 596153001143 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 596153001144 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153001145 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 596153001146 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153001147 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153001148 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 596153001149 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 596153001150 active site 596153001151 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153001152 hypothetical protein; Validated; Region: PRK06201 596153001153 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 596153001154 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 596153001155 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 596153001156 ligand binding site [chemical binding]; other site 596153001157 NAD binding site [chemical binding]; other site 596153001158 dimerization interface [polypeptide binding]; other site 596153001159 catalytic site [active] 596153001160 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153001161 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153001162 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 596153001163 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 596153001164 active site 596153001165 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 596153001166 Strictosidine synthase; Region: Str_synth; pfam03088 596153001167 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153001168 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 596153001169 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 596153001170 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 596153001171 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 596153001172 NAD(P) binding site [chemical binding]; other site 596153001173 catalytic residues [active] 596153001174 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153001175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 596153001176 putative Zn2+ binding site [ion binding]; other site 596153001177 putative DNA binding site [nucleotide binding]; other site 596153001178 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153001179 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 596153001180 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 596153001181 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 596153001182 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 596153001183 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 596153001184 TM-ABC transporter signature motif; other site 596153001185 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 596153001186 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 596153001187 TM-ABC transporter signature motif; other site 596153001188 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 596153001189 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 596153001190 Walker A/P-loop; other site 596153001191 ATP binding site [chemical binding]; other site 596153001192 Q-loop/lid; other site 596153001193 ABC transporter signature motif; other site 596153001194 Walker B; other site 596153001195 D-loop; other site 596153001196 H-loop/switch region; other site 596153001197 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 596153001198 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 596153001199 Walker A/P-loop; other site 596153001200 ATP binding site [chemical binding]; other site 596153001201 Q-loop/lid; other site 596153001202 ABC transporter signature motif; other site 596153001203 Walker B; other site 596153001204 D-loop; other site 596153001205 H-loop/switch region; other site 596153001206 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 596153001207 Amidohydrolase; Region: Amidohydro_2; pfam04909 596153001208 Transcriptional regulators [Transcription]; Region: GntR; COG1802 596153001209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153001210 DNA-binding site [nucleotide binding]; DNA binding site 596153001211 FCD domain; Region: FCD; cl11656 596153001212 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153001213 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153001214 active site 596153001215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153001216 short chain dehydrogenase; Provisional; Region: PRK06949 596153001217 NAD(P) binding site [chemical binding]; other site 596153001218 active site 596153001219 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 596153001220 Phosphotransferase enzyme family; Region: APH; pfam01636 596153001221 putative active site [active] 596153001222 putative substrate binding site [chemical binding]; other site 596153001223 ATP binding site [chemical binding]; other site 596153001224 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 596153001225 putative active site [active] 596153001226 putative catalytic site [active] 596153001227 putative DNA binding site [nucleotide binding]; other site 596153001228 putative phosphate binding site [ion binding]; other site 596153001229 metal binding site A [ion binding]; metal-binding site 596153001230 putative AP binding site [nucleotide binding]; other site 596153001231 putative metal binding site B [ion binding]; other site 596153001232 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 596153001233 active site 596153001234 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 596153001235 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 596153001236 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 596153001237 GatB domain; Region: GatB_Yqey; smart00845 596153001238 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 596153001239 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 596153001240 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 596153001241 rod shape-determining protein MreB; Provisional; Region: PRK13927 596153001242 MreB and similar proteins; Region: MreB_like; cd10225 596153001243 nucleotide binding site [chemical binding]; other site 596153001244 Mg binding site [ion binding]; other site 596153001245 putative protofilament interaction site [polypeptide binding]; other site 596153001246 RodZ interaction site [polypeptide binding]; other site 596153001247 rod shape-determining protein MreC; Provisional; Region: PRK13922 596153001248 rod shape-determining protein MreC; Region: MreC; pfam04085 596153001249 rod shape-determining protein MreD; Region: MreD; cl01087 596153001250 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 596153001251 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 596153001252 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 596153001253 Arginase family; Region: Arginase; cd09989 596153001254 active site 596153001255 Mn binding site [ion binding]; other site 596153001256 oligomer interface [polypeptide binding]; other site 596153001257 hypothetical protein; Provisional; Region: PRK10621 596153001258 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 596153001259 choline dehydrogenase; Validated; Region: PRK02106 596153001260 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 596153001261 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 596153001262 Permease; Region: Permease; pfam02405 596153001263 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 596153001264 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 596153001265 Walker A/P-loop; other site 596153001266 ATP binding site [chemical binding]; other site 596153001267 Q-loop/lid; other site 596153001268 ABC transporter signature motif; other site 596153001269 Walker B; other site 596153001270 D-loop; other site 596153001271 H-loop/switch region; other site 596153001272 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 596153001273 mce related protein; Region: MCE; pfam02470 596153001274 Flagellar protein FlbT; Region: FlbT; cl11455 596153001275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153001276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153001277 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 596153001278 putative dimerization interface [polypeptide binding]; other site 596153001279 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 596153001280 substrate binding site [chemical binding]; other site 596153001281 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 596153001282 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 596153001283 substrate binding site [chemical binding]; other site 596153001284 ligand binding site [chemical binding]; other site 596153001285 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153001286 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 596153001287 MarC family integral membrane protein; Region: MarC; cl00919 596153001288 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 596153001289 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 596153001290 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 596153001291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153001292 putative substrate translocation pore; other site 596153001293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153001294 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 596153001295 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 596153001296 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 596153001297 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 596153001298 MarR family; Region: MarR; pfam01047 596153001299 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 596153001300 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 596153001301 oligomer interface [polypeptide binding]; other site 596153001302 metal binding site [ion binding]; metal-binding site 596153001303 metal binding site [ion binding]; metal-binding site 596153001304 putative Cl binding site [ion binding]; other site 596153001305 aspartate ring; other site 596153001306 basic sphincter; other site 596153001307 hydrophobic gate; other site 596153001308 periplasmic entrance; other site 596153001309 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 596153001310 dimer interface [polypeptide binding]; other site 596153001311 allosteric magnesium binding site [ion binding]; other site 596153001312 active site 596153001313 aspartate-rich active site metal binding site; other site 596153001314 Schiff base residues; other site 596153001315 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 596153001316 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 596153001317 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 596153001318 dimer interface [polypeptide binding]; other site 596153001319 [2Fe-2S] cluster binding site [ion binding]; other site 596153001320 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 596153001321 Serine hydrolase; Region: Ser_hydrolase; cl17834 596153001322 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 596153001323 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 596153001324 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 596153001325 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 596153001326 S17 interaction site [polypeptide binding]; other site 596153001327 S8 interaction site; other site 596153001328 16S rRNA interaction site [nucleotide binding]; other site 596153001329 streptomycin interaction site [chemical binding]; other site 596153001330 23S rRNA interaction site [nucleotide binding]; other site 596153001331 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 596153001332 30S ribosomal protein S7; Validated; Region: PRK05302 596153001333 elongation factor G; Reviewed; Region: PRK00007 596153001334 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 596153001335 G1 box; other site 596153001336 putative GEF interaction site [polypeptide binding]; other site 596153001337 GTP/Mg2+ binding site [chemical binding]; other site 596153001338 Switch I region; other site 596153001339 G2 box; other site 596153001340 G3 box; other site 596153001341 Switch II region; other site 596153001342 G4 box; other site 596153001343 G5 box; other site 596153001344 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 596153001345 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 596153001346 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 596153001347 elongation factor Tu; Reviewed; Region: PRK00049 596153001348 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 596153001349 G1 box; other site 596153001350 GEF interaction site [polypeptide binding]; other site 596153001351 GTP/Mg2+ binding site [chemical binding]; other site 596153001352 Switch I region; other site 596153001353 G2 box; other site 596153001354 G3 box; other site 596153001355 Switch II region; other site 596153001356 G4 box; other site 596153001357 G5 box; other site 596153001358 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 596153001359 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 596153001360 Antibiotic Binding Site [chemical binding]; other site 596153001361 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 596153001362 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 596153001363 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 596153001364 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 596153001365 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 596153001366 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 596153001367 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 596153001368 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 596153001369 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 596153001370 putative translocon binding site; other site 596153001371 protein-rRNA interface [nucleotide binding]; other site 596153001372 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 596153001373 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 596153001374 G-X-X-G motif; other site 596153001375 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 596153001376 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 596153001377 23S rRNA interface [nucleotide binding]; other site 596153001378 5S rRNA interface [nucleotide binding]; other site 596153001379 putative antibiotic binding site [chemical binding]; other site 596153001380 L25 interface [polypeptide binding]; other site 596153001381 L27 interface [polypeptide binding]; other site 596153001382 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 596153001383 23S rRNA interface [nucleotide binding]; other site 596153001384 putative translocon interaction site; other site 596153001385 signal recognition particle (SRP54) interaction site; other site 596153001386 L23 interface [polypeptide binding]; other site 596153001387 trigger factor interaction site; other site 596153001388 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 596153001389 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 596153001390 catalytic triad [active] 596153001391 dimer interface [polypeptide binding]; other site 596153001392 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 596153001393 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 596153001394 Coenzyme A binding pocket [chemical binding]; other site 596153001395 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 596153001396 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 596153001397 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 596153001398 catalytic residues [active] 596153001399 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 596153001400 active site 596153001401 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 596153001402 dimerization domain swap beta strand [polypeptide binding]; other site 596153001403 regulatory protein interface [polypeptide binding]; other site 596153001404 active site 596153001405 regulatory phosphorylation site [posttranslational modification]; other site 596153001406 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 596153001407 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 596153001408 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 596153001409 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 596153001410 lipoyl synthase; Provisional; Region: PRK05481 596153001411 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 596153001412 FeS/SAM binding site; other site 596153001413 lipoate-protein ligase B; Provisional; Region: PRK14346 596153001414 Protein of unknown function (DUF493); Region: DUF493; cl01102 596153001415 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 596153001416 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 596153001417 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 596153001418 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 596153001419 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 596153001420 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 596153001421 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 596153001422 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 596153001423 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 596153001424 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 596153001425 beta subunit interaction interface [polypeptide binding]; other site 596153001426 Walker A motif; other site 596153001427 ATP binding site [chemical binding]; other site 596153001428 Walker B motif; other site 596153001429 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 596153001430 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 596153001431 core domain interface [polypeptide binding]; other site 596153001432 delta subunit interface [polypeptide binding]; other site 596153001433 epsilon subunit interface [polypeptide binding]; other site 596153001434 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 596153001435 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 596153001436 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 596153001437 alpha subunit interaction interface [polypeptide binding]; other site 596153001438 Walker A motif; other site 596153001439 ATP binding site [chemical binding]; other site 596153001440 Walker B motif; other site 596153001441 inhibitor binding site; inhibition site 596153001442 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 596153001443 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 596153001444 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 596153001445 gamma subunit interface [polypeptide binding]; other site 596153001446 epsilon subunit interface [polypeptide binding]; other site 596153001447 LBP interface [polypeptide binding]; other site 596153001448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153001449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153001450 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 596153001451 putative effector binding pocket; other site 596153001452 putative dimerization interface [polypeptide binding]; other site 596153001453 Repair protein; Region: Repair_PSII; pfam04536 596153001454 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 596153001455 Repair protein; Region: Repair_PSII; pfam04536 596153001456 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 596153001457 SnoaL-like domain; Region: SnoaL_3; pfam13474 596153001458 SnoaL-like domain; Region: SnoaL_2; pfam12680 596153001459 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 596153001460 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 596153001461 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 596153001462 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 596153001463 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 596153001464 HlyD family secretion protein; Region: HlyD_3; pfam13437 596153001465 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 596153001466 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 596153001467 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 596153001468 elongation factor Tu; Reviewed; Region: PRK00049 596153001469 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 596153001470 G1 box; other site 596153001471 GEF interaction site [polypeptide binding]; other site 596153001472 GTP/Mg2+ binding site [chemical binding]; other site 596153001473 Switch I region; other site 596153001474 G2 box; other site 596153001475 G3 box; other site 596153001476 Switch II region; other site 596153001477 G4 box; other site 596153001478 G5 box; other site 596153001479 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 596153001480 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 596153001481 Antibiotic Binding Site [chemical binding]; other site 596153001482 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 596153001483 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 596153001484 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 596153001485 putative homodimer interface [polypeptide binding]; other site 596153001486 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 596153001487 heterodimer interface [polypeptide binding]; other site 596153001488 homodimer interface [polypeptide binding]; other site 596153001489 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 596153001490 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 596153001491 23S rRNA interface [nucleotide binding]; other site 596153001492 L7/L12 interface [polypeptide binding]; other site 596153001493 putative thiostrepton binding site; other site 596153001494 L25 interface [polypeptide binding]; other site 596153001495 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 596153001496 mRNA/rRNA interface [nucleotide binding]; other site 596153001497 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 596153001498 23S rRNA interface [nucleotide binding]; other site 596153001499 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 596153001500 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 596153001501 peripheral dimer interface [polypeptide binding]; other site 596153001502 core dimer interface [polypeptide binding]; other site 596153001503 L10 interface [polypeptide binding]; other site 596153001504 L11 interface [polypeptide binding]; other site 596153001505 putative EF-Tu interaction site [polypeptide binding]; other site 596153001506 putative EF-G interaction site [polypeptide binding]; other site 596153001507 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 596153001508 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 596153001509 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 596153001510 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 596153001511 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 596153001512 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 596153001513 RPB3 interaction site [polypeptide binding]; other site 596153001514 RPB1 interaction site [polypeptide binding]; other site 596153001515 RPB11 interaction site [polypeptide binding]; other site 596153001516 RPB10 interaction site [polypeptide binding]; other site 596153001517 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 596153001518 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 596153001519 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 596153001520 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 596153001521 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 596153001522 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 596153001523 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 596153001524 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 596153001525 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 596153001526 DNA binding site [nucleotide binding] 596153001527 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 596153001528 LemA family; Region: LemA; cl00742 596153001529 16S rRNA methyltransferase B; Provisional; Region: PRK10901 596153001530 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 596153001531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153001532 S-adenosylmethionine binding site [chemical binding]; other site 596153001533 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 596153001534 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 596153001535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 596153001536 dimerization interface [polypeptide binding]; other site 596153001537 PAS domain; Region: PAS; smart00091 596153001538 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153001539 dimer interface [polypeptide binding]; other site 596153001540 phosphorylation site [posttranslational modification] 596153001541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153001542 ATP binding site [chemical binding]; other site 596153001543 Mg2+ binding site [ion binding]; other site 596153001544 G-X-G motif; other site 596153001545 Response regulator receiver domain; Region: Response_reg; pfam00072 596153001546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153001547 active site 596153001548 phosphorylation site [posttranslational modification] 596153001549 intermolecular recognition site; other site 596153001550 dimerization interface [polypeptide binding]; other site 596153001551 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 596153001552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 596153001553 sequence-specific DNA binding site [nucleotide binding]; other site 596153001554 salt bridge; other site 596153001555 Domain of unknown function (DUF955); Region: DUF955; pfam06114 596153001556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 596153001557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 596153001558 non-specific DNA binding site [nucleotide binding]; other site 596153001559 salt bridge; other site 596153001560 sequence-specific DNA binding site [nucleotide binding]; other site 596153001561 Integrase core domain; Region: rve; pfam00665 596153001562 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 596153001563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153001564 Walker A motif; other site 596153001565 ATP binding site [chemical binding]; other site 596153001566 Walker B motif; other site 596153001567 arginine finger; other site 596153001568 Domain of unknown function (DUF955); Region: DUF955; cl01076 596153001569 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 596153001570 active site 596153001571 Zn binding site [ion binding]; other site 596153001572 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 596153001573 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 596153001574 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 596153001575 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 596153001576 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 596153001577 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 596153001578 putative NAD(P) binding site [chemical binding]; other site 596153001579 active site 596153001580 putative substrate binding site [chemical binding]; other site 596153001581 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 596153001582 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 596153001583 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 596153001584 Ligand binding site; other site 596153001585 Putative Catalytic site; other site 596153001586 DXD motif; other site 596153001587 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 596153001588 Predicted methyltransferases [General function prediction only]; Region: COG0313 596153001589 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 596153001590 putative SAM binding site [chemical binding]; other site 596153001591 putative homodimer interface [polypeptide binding]; other site 596153001592 hypothetical protein; Provisional; Region: PRK14673 596153001593 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 596153001594 dimer interface [polypeptide binding]; other site 596153001595 active site 596153001596 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 596153001597 BON domain; Region: BON; pfam04972 596153001598 BON domain; Region: BON; pfam04972 596153001599 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 596153001600 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 596153001601 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 596153001602 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 596153001603 Walker A motif; other site 596153001604 ATP binding site [chemical binding]; other site 596153001605 Walker B motif; other site 596153001606 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 596153001607 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 596153001608 ligand binding site [chemical binding]; other site 596153001609 flexible hinge region; other site 596153001610 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 596153001611 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 596153001612 Walker A motif; other site 596153001613 ATP binding site [chemical binding]; other site 596153001614 Walker B motif; other site 596153001615 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 596153001616 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 596153001617 catalytic residue [active] 596153001618 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 596153001619 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 596153001620 catalytic residue [active] 596153001621 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 596153001622 Protein of unknown function (DUF445); Region: DUF445; pfam04286 596153001623 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 596153001624 FAD binding domain; Region: FAD_binding_4; pfam01565 596153001625 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 596153001626 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153001627 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 596153001628 dimerization interface [polypeptide binding]; other site 596153001629 substrate binding pocket [chemical binding]; other site 596153001630 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 596153001631 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 596153001632 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 596153001633 putative active site [active] 596153001634 putative substrate binding site [chemical binding]; other site 596153001635 putative cosubstrate binding site; other site 596153001636 catalytic site [active] 596153001637 PAS domain; Region: PAS_9; pfam13426 596153001638 PAS fold; Region: PAS; pfam00989 596153001639 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153001640 heme pocket [chemical binding]; other site 596153001641 putative active site [active] 596153001642 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153001643 PAS domain; Region: PAS_9; pfam13426 596153001644 putative active site [active] 596153001645 heme pocket [chemical binding]; other site 596153001646 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153001647 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153001648 metal binding site [ion binding]; metal-binding site 596153001649 active site 596153001650 I-site; other site 596153001651 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 596153001652 Protein of unknown function, DUF399; Region: DUF399; cl01139 596153001653 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 596153001654 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 596153001655 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 596153001656 active site 596153001657 dimer interface [polypeptide binding]; other site 596153001658 effector binding site; other site 596153001659 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 596153001660 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 596153001661 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 596153001662 dimerization interface [polypeptide binding]; other site 596153001663 GAF domain; Region: GAF; pfam01590 596153001664 Histidine kinase; Region: HisKA_3; pfam07730 596153001665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153001666 ATP binding site [chemical binding]; other site 596153001667 Mg2+ binding site [ion binding]; other site 596153001668 G-X-G motif; other site 596153001669 transcriptional regulator NarL; Provisional; Region: PRK10651 596153001670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153001671 active site 596153001672 phosphorylation site [posttranslational modification] 596153001673 intermolecular recognition site; other site 596153001674 dimerization interface [polypeptide binding]; other site 596153001675 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 596153001676 DNA binding residues [nucleotide binding] 596153001677 dimerization interface [polypeptide binding]; other site 596153001678 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 596153001679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153001680 putative substrate translocation pore; other site 596153001681 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 596153001682 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 596153001683 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 596153001684 [4Fe-4S] binding site [ion binding]; other site 596153001685 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 596153001686 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 596153001687 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 596153001688 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 596153001689 molybdopterin cofactor binding site; other site 596153001690 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 596153001691 4Fe-4S binding domain; Region: Fer4; cl02805 596153001692 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 596153001693 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 596153001694 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 596153001695 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 596153001696 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 596153001697 active site clefts [active] 596153001698 zinc binding site [ion binding]; other site 596153001699 dimer interface [polypeptide binding]; other site 596153001700 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 596153001701 putative FMN binding site [chemical binding]; other site 596153001702 Hemerythrin-like domain; Region: Hr-like; cd12108 596153001703 Fe binding site [ion binding]; other site 596153001704 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 596153001705 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 596153001706 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 596153001707 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 596153001708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 596153001709 TPR repeat; Region: TPR_11; pfam13414 596153001710 binding surface 596153001711 TPR motif; other site 596153001712 TPR repeat; Region: TPR_11; pfam13414 596153001713 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 596153001714 binding surface 596153001715 TPR motif; other site 596153001716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 596153001717 binding surface 596153001718 TPR motif; other site 596153001719 TPR repeat; Region: TPR_11; pfam13414 596153001720 TPR repeat; Region: TPR_11; pfam13414 596153001721 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 596153001722 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 596153001723 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 596153001724 putative [4Fe-4S] binding site [ion binding]; other site 596153001725 putative molybdopterin cofactor binding site [chemical binding]; other site 596153001726 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 596153001727 molybdopterin cofactor binding site; other site 596153001728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153001729 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 596153001730 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153001731 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153001732 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 596153001733 putative active site [active] 596153001734 putative catalytic site [active] 596153001735 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153001736 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153001737 active site 596153001738 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 596153001739 putative active site [active] 596153001740 putative catalytic site [active] 596153001741 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 596153001742 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 596153001743 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153001744 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 596153001745 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153001746 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 596153001747 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 596153001748 metal binding site [ion binding]; metal-binding site 596153001749 putative dimer interface [polypeptide binding]; other site 596153001750 Acyl CoA binding protein; Region: ACBP; pfam00887 596153001751 acyl-CoA binding pocket [chemical binding]; other site 596153001752 CoA binding site [chemical binding]; other site 596153001753 Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720 596153001754 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 596153001755 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 596153001756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153001757 S-adenosylmethionine binding site [chemical binding]; other site 596153001758 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 596153001759 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153001760 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153001761 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153001762 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 596153001763 acyl-activating enzyme (AAE) consensus motif; other site 596153001764 active site 596153001765 AMP binding site [chemical binding]; other site 596153001766 CoA binding site [chemical binding]; other site 596153001767 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 596153001768 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 596153001769 Walker A/P-loop; other site 596153001770 ATP binding site [chemical binding]; other site 596153001771 Q-loop/lid; other site 596153001772 ABC transporter signature motif; other site 596153001773 Walker B; other site 596153001774 D-loop; other site 596153001775 H-loop/switch region; other site 596153001776 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153001777 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 596153001778 putative ligand binding site [chemical binding]; other site 596153001779 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 596153001780 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 596153001781 TM-ABC transporter signature motif; other site 596153001782 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 596153001783 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 596153001784 TM-ABC transporter signature motif; other site 596153001785 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 596153001786 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 596153001787 Walker A/P-loop; other site 596153001788 ATP binding site [chemical binding]; other site 596153001789 Q-loop/lid; other site 596153001790 ABC transporter signature motif; other site 596153001791 Walker B; other site 596153001792 D-loop; other site 596153001793 H-loop/switch region; other site 596153001794 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 596153001795 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 596153001796 putative AMP binding site [chemical binding]; other site 596153001797 putative active site [active] 596153001798 putative CoA binding site [chemical binding]; other site 596153001799 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 596153001800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153001801 Walker A motif; other site 596153001802 ATP binding site [chemical binding]; other site 596153001803 Walker B motif; other site 596153001804 arginine finger; other site 596153001805 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 596153001806 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 596153001807 ligand binding site [chemical binding]; other site 596153001808 flexible hinge region; other site 596153001809 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 596153001810 non-specific DNA interactions [nucleotide binding]; other site 596153001811 DNA binding site [nucleotide binding] 596153001812 sequence specific DNA binding site [nucleotide binding]; other site 596153001813 putative cAMP binding site [chemical binding]; other site 596153001814 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 596153001815 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 596153001816 RNA binding surface [nucleotide binding]; other site 596153001817 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 596153001818 active site 596153001819 heat shock protein 90; Provisional; Region: PRK05218 596153001820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153001821 ATP binding site [chemical binding]; other site 596153001822 Mg2+ binding site [ion binding]; other site 596153001823 G-X-G motif; other site 596153001824 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153001825 serine/threonine protein kinase; Provisional; Region: PRK11768 596153001826 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 596153001827 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 596153001828 Catalytic domain of Protein Kinases; Region: PKc; cd00180 596153001829 active site 596153001830 ATP binding site [chemical binding]; other site 596153001831 substrate binding site [chemical binding]; other site 596153001832 activation loop (A-loop); other site 596153001833 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 596153001834 Ligand Binding Site [chemical binding]; other site 596153001835 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 596153001836 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 596153001837 active site 596153001838 metal binding site [ion binding]; metal-binding site 596153001839 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153001840 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153001841 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 596153001842 active site 596153001843 catalytic site [active] 596153001844 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153001845 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 596153001846 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 596153001847 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 596153001848 choline dehydrogenase; Validated; Region: PRK02106 596153001849 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 596153001850 ABC-2 type transporter; Region: ABC2_membrane; cl17235 596153001851 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 596153001852 nodulation ABC transporter NodI; Provisional; Region: PRK13537 596153001853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 596153001854 Walker A/P-loop; other site 596153001855 ATP binding site [chemical binding]; other site 596153001856 Q-loop/lid; other site 596153001857 ABC transporter signature motif; other site 596153001858 Walker B; other site 596153001859 D-loop; other site 596153001860 H-loop/switch region; other site 596153001861 Tannase and feruloyl esterase; Region: Tannase; pfam07519 596153001862 AMP nucleosidase; Provisional; Region: PRK08292 596153001863 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 596153001864 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 596153001865 PAS fold; Region: PAS_4; pfam08448 596153001866 PAS domain S-box; Region: sensory_box; TIGR00229 596153001867 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153001868 putative active site [active] 596153001869 heme pocket [chemical binding]; other site 596153001870 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153001871 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153001872 metal binding site [ion binding]; metal-binding site 596153001873 active site 596153001874 I-site; other site 596153001875 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 596153001876 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 596153001877 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 596153001878 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 596153001879 putative active site [active] 596153001880 dimerization interface [polypeptide binding]; other site 596153001881 putative tRNAtyr binding site [nucleotide binding]; other site 596153001882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153001883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153001884 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 596153001885 dimerization interface [polypeptide binding]; other site 596153001886 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153001887 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153001888 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153001889 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 596153001890 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 596153001891 NADP binding site [chemical binding]; other site 596153001892 dimer interface [polypeptide binding]; other site 596153001893 acyl-CoA synthetase; Validated; Region: PRK06188 596153001894 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153001895 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 596153001896 acyl-activating enzyme (AAE) consensus motif; other site 596153001897 acyl-activating enzyme (AAE) consensus motif; other site 596153001898 putative AMP binding site [chemical binding]; other site 596153001899 putative active site [active] 596153001900 putative CoA binding site [chemical binding]; other site 596153001901 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 596153001902 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 596153001903 PhoH-like protein; Region: PhoH; pfam02562 596153001904 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 596153001905 RuvA N terminal domain; Region: RuvA_N; pfam01330 596153001906 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 596153001907 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 596153001908 nucleotide binding site [chemical binding]; other site 596153001909 putative NEF/HSP70 interaction site [polypeptide binding]; other site 596153001910 SBD interface [polypeptide binding]; other site 596153001911 DNA-K related protein; Region: DUF3731; pfam12531 596153001912 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 596153001913 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 596153001914 nucleotide binding site [chemical binding]; other site 596153001915 putative NEF/HSP70 interaction site [polypeptide binding]; other site 596153001916 SBD interface [polypeptide binding]; other site 596153001917 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 596153001918 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 596153001919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153001920 Walker A motif; other site 596153001921 ATP binding site [chemical binding]; other site 596153001922 Walker B motif; other site 596153001923 arginine finger; other site 596153001924 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 596153001925 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 596153001926 MgtC family; Region: MgtC; pfam02308 596153001927 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 596153001928 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 596153001929 dimer interface [polypeptide binding]; other site 596153001930 active site 596153001931 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 596153001932 substrate binding site [chemical binding]; other site 596153001933 catalytic residue [active] 596153001934 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 596153001935 catalytic core [active] 596153001936 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 596153001937 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 596153001938 Ligand Binding Site [chemical binding]; other site 596153001939 Dihydroneopterin aldolase; Region: FolB; smart00905 596153001940 active site 596153001941 Dihydroneopterin aldolase; Region: FolB; smart00905 596153001942 active site 596153001943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153001944 short chain dehydrogenase; Provisional; Region: PRK09134 596153001945 NAD(P) binding site [chemical binding]; other site 596153001946 active site 596153001947 Uncharacterized conserved protein [Function unknown]; Region: COG1565 596153001948 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 596153001949 dimer interface [polypeptide binding]; other site 596153001950 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 596153001951 metal binding site [ion binding]; metal-binding site 596153001952 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 596153001953 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 596153001954 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 596153001955 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 596153001956 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 596153001957 active site 596153001958 homotetramer interface [polypeptide binding]; other site 596153001959 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 596153001960 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 596153001961 thioredoxin 2; Provisional; Region: PRK10996 596153001962 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 596153001963 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 596153001964 catalytic residues [active] 596153001965 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 596153001966 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 596153001967 active site 596153001968 NTP binding site [chemical binding]; other site 596153001969 metal binding triad [ion binding]; metal-binding site 596153001970 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 596153001971 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 596153001972 Zn2+ binding site [ion binding]; other site 596153001973 Mg2+ binding site [ion binding]; other site 596153001974 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 596153001975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153001976 Walker A motif; other site 596153001977 ATP binding site [chemical binding]; other site 596153001978 Walker B motif; other site 596153001979 arginine finger; other site 596153001980 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 596153001981 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 596153001982 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 596153001983 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153001984 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 596153001985 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 596153001986 putative active site [active] 596153001987 putative metal binding site [ion binding]; other site 596153001988 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 596153001989 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 596153001990 putative C-terminal domain interface [polypeptide binding]; other site 596153001991 putative GSH binding site (G-site) [chemical binding]; other site 596153001992 putative dimer interface [polypeptide binding]; other site 596153001993 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 596153001994 putative N-terminal domain interface [polypeptide binding]; other site 596153001995 putative dimer interface [polypeptide binding]; other site 596153001996 putative substrate binding pocket (H-site) [chemical binding]; other site 596153001997 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 596153001998 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 596153001999 lytic murein transglycosylase; Provisional; Region: PRK11619 596153002000 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 596153002001 N-acetyl-D-glucosamine binding site [chemical binding]; other site 596153002002 catalytic residue [active] 596153002003 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 596153002004 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 596153002005 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 596153002006 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 596153002007 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 596153002008 active site 596153002009 substrate binding site [chemical binding]; other site 596153002010 FMN binding site [chemical binding]; other site 596153002011 putative catalytic residues [active] 596153002012 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 596153002013 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 596153002014 N-terminal plug; other site 596153002015 ligand-binding site [chemical binding]; other site 596153002016 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 596153002017 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 596153002018 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153002019 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 596153002020 acyl-activating enzyme (AAE) consensus motif; other site 596153002021 putative AMP binding site [chemical binding]; other site 596153002022 putative active site [active] 596153002023 putative CoA binding site [chemical binding]; other site 596153002024 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 596153002025 PGAP1-like protein; Region: PGAP1; pfam07819 596153002026 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 596153002027 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 596153002028 dimer interface [polypeptide binding]; other site 596153002029 active site 596153002030 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 596153002031 dimer interface [polypeptide binding]; other site 596153002032 active site 1 [active] 596153002033 active site 2 [active] 596153002034 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 596153002035 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 596153002036 putative active site [active] 596153002037 catalytic triad [active] 596153002038 putative dimer interface [polypeptide binding]; other site 596153002039 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 596153002040 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 596153002041 Transporter associated domain; Region: CorC_HlyC; smart01091 596153002042 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 596153002043 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 596153002044 Coenzyme A binding pocket [chemical binding]; other site 596153002045 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 596153002046 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 596153002047 AsnC family; Region: AsnC_trans_reg; pfam01037 596153002048 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 596153002049 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 596153002050 dimer interface [polypeptide binding]; other site 596153002051 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 596153002052 active site 596153002053 Fe binding site [ion binding]; other site 596153002054 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 596153002055 cofactor binding site; other site 596153002056 metal binding site [ion binding]; metal-binding site 596153002057 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 596153002058 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 596153002059 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 596153002060 tetramer interface [polypeptide binding]; other site 596153002061 TPP-binding site [chemical binding]; other site 596153002062 heterodimer interface [polypeptide binding]; other site 596153002063 phosphorylation loop region [posttranslational modification] 596153002064 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 596153002065 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 596153002066 alpha subunit interface [polypeptide binding]; other site 596153002067 TPP binding site [chemical binding]; other site 596153002068 heterodimer interface [polypeptide binding]; other site 596153002069 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 596153002070 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 596153002071 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 596153002072 E3 interaction surface; other site 596153002073 lipoyl attachment site [posttranslational modification]; other site 596153002074 e3 binding domain; Region: E3_binding; pfam02817 596153002075 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 596153002076 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 596153002077 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 596153002078 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 596153002079 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 596153002080 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 596153002081 dimer interface [polypeptide binding]; other site 596153002082 motif 1; other site 596153002083 active site 596153002084 motif 2; other site 596153002085 motif 3; other site 596153002086 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 596153002087 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 596153002088 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 596153002089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 596153002090 active site 596153002091 motif I; other site 596153002092 motif II; other site 596153002093 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 596153002094 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 596153002095 putative acyl-acceptor binding pocket; other site 596153002096 Protein of unknown function DUF45; Region: DUF45; pfam01863 596153002097 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 596153002098 active site residue [active] 596153002099 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 596153002100 BON domain; Region: BON; pfam04972 596153002101 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 596153002102 pantothenate kinase; Reviewed; Region: PRK13329 596153002103 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 596153002104 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 596153002105 Bacterial transcriptional repressor; Region: TetR; pfam13972 596153002106 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 596153002107 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 596153002108 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 596153002109 NAD binding site [chemical binding]; other site 596153002110 substrate binding site [chemical binding]; other site 596153002111 homodimer interface [polypeptide binding]; other site 596153002112 active site 596153002113 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 596153002114 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 596153002115 NADP binding site [chemical binding]; other site 596153002116 active site 596153002117 putative substrate binding site [chemical binding]; other site 596153002118 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 596153002119 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 596153002120 substrate binding site; other site 596153002121 tetramer interface; other site 596153002122 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 596153002123 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 596153002124 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 596153002125 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 596153002126 Ligand binding site; other site 596153002127 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 596153002128 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 596153002129 type II secretion system protein E; Region: type_II_gspE; TIGR02533 596153002130 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 596153002131 Walker A motif; other site 596153002132 ATP binding site [chemical binding]; other site 596153002133 Walker B motif; other site 596153002134 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 596153002135 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 596153002136 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 596153002137 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 596153002138 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 596153002139 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 596153002140 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 596153002141 general secretion pathway protein J; Validated; Region: PRK08808 596153002142 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 596153002143 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 596153002144 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 596153002145 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 596153002146 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 596153002147 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 596153002148 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 596153002149 Family description; Region: VCBS; pfam13517 596153002150 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 596153002151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 596153002152 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 596153002153 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 596153002154 active site 596153002155 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 596153002156 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 596153002157 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 596153002158 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 596153002159 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 596153002160 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 596153002161 Walker A/P-loop; other site 596153002162 ATP binding site [chemical binding]; other site 596153002163 Q-loop/lid; other site 596153002164 ABC transporter signature motif; other site 596153002165 Walker B; other site 596153002166 D-loop; other site 596153002167 H-loop/switch region; other site 596153002168 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 596153002169 putative carbohydrate binding site [chemical binding]; other site 596153002170 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 596153002171 putative acyl-acceptor binding pocket; other site 596153002172 Methyltransferase domain; Region: Methyltransf_23; pfam13489 596153002173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153002174 S-adenosylmethionine binding site [chemical binding]; other site 596153002175 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 596153002176 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 596153002177 N-acetyl-D-glucosamine binding site [chemical binding]; other site 596153002178 catalytic residue [active] 596153002179 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 596153002180 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 596153002181 Mg++ binding site [ion binding]; other site 596153002182 putative catalytic motif [active] 596153002183 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 596153002184 feedback inhibition sensing region; other site 596153002185 homohexameric interface [polypeptide binding]; other site 596153002186 nucleotide binding site [chemical binding]; other site 596153002187 N-acetyl-L-glutamate binding site [chemical binding]; other site 596153002188 division inhibitor protein; Provisional; Region: slmA; PRK09480 596153002189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 596153002190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 596153002191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 596153002192 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 596153002193 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 596153002194 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153002195 active site 596153002196 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 596153002197 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 596153002198 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 596153002199 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 596153002200 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 596153002201 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153002202 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 596153002203 substrate binding site [chemical binding]; other site 596153002204 oxyanion hole (OAH) forming residues; other site 596153002205 trimer interface [polypeptide binding]; other site 596153002206 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 596153002207 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 596153002208 dimer interface [polypeptide binding]; other site 596153002209 active site 596153002210 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 596153002211 enoyl-CoA hydratase; Provisional; Region: PRK06688 596153002212 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153002213 substrate binding site [chemical binding]; other site 596153002214 oxyanion hole (OAH) forming residues; other site 596153002215 trimer interface [polypeptide binding]; other site 596153002216 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 596153002217 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 596153002218 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 596153002219 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 596153002220 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 596153002221 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 596153002222 Walker A/P-loop; other site 596153002223 ATP binding site [chemical binding]; other site 596153002224 Q-loop/lid; other site 596153002225 ABC transporter signature motif; other site 596153002226 Walker B; other site 596153002227 D-loop; other site 596153002228 H-loop/switch region; other site 596153002229 acyl-CoA synthetase; Validated; Region: PRK06164 596153002230 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153002231 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153002232 acyl-activating enzyme (AAE) consensus motif; other site 596153002233 AMP binding site [chemical binding]; other site 596153002234 active site 596153002235 CoA binding site [chemical binding]; other site 596153002236 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 596153002237 active site 2 [active] 596153002238 active site 1 [active] 596153002239 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153002240 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 596153002241 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 596153002242 FMN binding site [chemical binding]; other site 596153002243 substrate binding site [chemical binding]; other site 596153002244 putative catalytic residue [active] 596153002245 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153002246 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153002247 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 596153002248 putative effector binding pocket; other site 596153002249 dimerization interface [polypeptide binding]; other site 596153002250 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 596153002251 homodimer interface [polypeptide binding]; other site 596153002252 chemical substrate binding site [chemical binding]; other site 596153002253 oligomer interface [polypeptide binding]; other site 596153002254 metal binding site [ion binding]; metal-binding site 596153002255 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 596153002256 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 596153002257 DctM-like transporters; Region: DctM; pfam06808 596153002258 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 596153002259 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 596153002260 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153002261 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153002262 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 596153002263 dimerization interface [polypeptide binding]; other site 596153002264 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 596153002265 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 596153002266 substrate binding pocket [chemical binding]; other site 596153002267 membrane-bound complex binding site; other site 596153002268 hinge residues; other site 596153002269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153002270 dimer interface [polypeptide binding]; other site 596153002271 conserved gate region; other site 596153002272 putative PBP binding loops; other site 596153002273 ABC-ATPase subunit interface; other site 596153002274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153002275 dimer interface [polypeptide binding]; other site 596153002276 conserved gate region; other site 596153002277 putative PBP binding loops; other site 596153002278 ABC-ATPase subunit interface; other site 596153002279 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 596153002280 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 596153002281 Walker A/P-loop; other site 596153002282 ATP binding site [chemical binding]; other site 596153002283 Q-loop/lid; other site 596153002284 ABC transporter signature motif; other site 596153002285 Walker B; other site 596153002286 D-loop; other site 596153002287 H-loop/switch region; other site 596153002288 ornithine cyclodeaminase; Validated; Region: PRK07589 596153002289 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 596153002290 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 596153002291 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 596153002292 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 596153002293 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 596153002294 G1 box; other site 596153002295 putative GEF interaction site [polypeptide binding]; other site 596153002296 GTP/Mg2+ binding site [chemical binding]; other site 596153002297 Switch I region; other site 596153002298 G2 box; other site 596153002299 G3 box; other site 596153002300 Switch II region; other site 596153002301 G4 box; other site 596153002302 G5 box; other site 596153002303 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 596153002304 classical (c) SDRs; Region: SDR_c; cd05233 596153002305 short chain dehydrogenase; Provisional; Region: PRK05650 596153002306 NAD(P) binding site [chemical binding]; other site 596153002307 active site 596153002308 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 596153002309 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 596153002310 homotetramer interface [polypeptide binding]; other site 596153002311 ligand binding site [chemical binding]; other site 596153002312 catalytic site [active] 596153002313 NAD binding site [chemical binding]; other site 596153002314 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 596153002315 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 596153002316 FtsJ-like methyltransferase; Region: FtsJ; cl17430 596153002317 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 596153002318 FAD binding site [chemical binding]; other site 596153002319 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 596153002320 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 596153002321 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 596153002322 Protein kinase domain; Region: Pkinase; pfam00069 596153002323 Catalytic domain of Protein Kinases; Region: PKc; cd00180 596153002324 active site 596153002325 ATP binding site [chemical binding]; other site 596153002326 substrate binding site [chemical binding]; other site 596153002327 activation loop (A-loop); other site 596153002328 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 596153002329 23S rRNA interface [nucleotide binding]; other site 596153002330 L3 interface [polypeptide binding]; other site 596153002331 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 596153002332 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 596153002333 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 596153002334 putative peptidase; Provisional; Region: PRK11649 596153002335 Peptidase family M23; Region: Peptidase_M23; pfam01551 596153002336 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 596153002337 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 596153002338 active site 596153002339 HIGH motif; other site 596153002340 dimer interface [polypeptide binding]; other site 596153002341 KMSKS motif; other site 596153002342 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153002343 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 596153002344 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153002345 dimerization interface [polypeptide binding]; other site 596153002346 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 596153002347 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 596153002348 Substrate binding site; other site 596153002349 Mg++ binding site; other site 596153002350 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 596153002351 active site 596153002352 substrate binding site [chemical binding]; other site 596153002353 CoA binding site [chemical binding]; other site 596153002354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153002355 dimer interface [polypeptide binding]; other site 596153002356 phosphorylation site [posttranslational modification] 596153002357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153002358 ATP binding site [chemical binding]; other site 596153002359 G-X-G motif; other site 596153002360 chaperone protein DnaJ; Provisional; Region: PRK14299 596153002361 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 596153002362 HSP70 interaction site [polypeptide binding]; other site 596153002363 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 596153002364 substrate binding site [polypeptide binding]; other site 596153002365 dimer interface [polypeptide binding]; other site 596153002366 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 596153002367 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 596153002368 AsnC family; Region: AsnC_trans_reg; pfam01037 596153002369 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 596153002370 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 596153002371 glutaminase active site [active] 596153002372 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 596153002373 dimer interface [polypeptide binding]; other site 596153002374 active site 596153002375 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 596153002376 dimer interface [polypeptide binding]; other site 596153002377 active site 596153002378 Domain of unknown function (DUF4209); Region: DUF4209; pfam13910 596153002379 putative transposase OrfB; Reviewed; Region: PHA02517 596153002380 HTH-like domain; Region: HTH_21; pfam13276 596153002381 Integrase core domain; Region: rve; pfam00665 596153002382 Integrase core domain; Region: rve_3; cl15866 596153002383 Transposase; Region: HTH_Tnp_1; cl17663 596153002384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153002385 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 596153002386 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 596153002387 Moco binding site; other site 596153002388 metal coordination site [ion binding]; other site 596153002389 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 596153002390 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 596153002391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153002392 active site 596153002393 phosphorylation site [posttranslational modification] 596153002394 intermolecular recognition site; other site 596153002395 dimerization interface [polypeptide binding]; other site 596153002396 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 596153002397 DNA binding site [nucleotide binding] 596153002398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153002399 dimer interface [polypeptide binding]; other site 596153002400 phosphorylation site [posttranslational modification] 596153002401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153002402 ATP binding site [chemical binding]; other site 596153002403 Mg2+ binding site [ion binding]; other site 596153002404 G-X-G motif; other site 596153002405 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 596153002406 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 596153002407 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 596153002408 Substrate binding site; other site 596153002409 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 596153002410 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 596153002411 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 596153002412 SLBB domain; Region: SLBB; pfam10531 596153002413 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 596153002414 Chain length determinant protein; Region: Wzz; cl15801 596153002415 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 596153002416 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 596153002417 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 596153002418 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 596153002419 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 596153002420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153002421 Walker A motif; other site 596153002422 ATP binding site [chemical binding]; other site 596153002423 Walker B motif; other site 596153002424 arginine finger; other site 596153002425 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 596153002426 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 596153002427 putative active site [active] 596153002428 putative catalytic site [active] 596153002429 FemAB-related protein, PEP-CTERM system-associated; Region: pepcterm_femAB; TIGR03019 596153002430 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 596153002431 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 596153002432 exosortase A; Region: exosortase_1; TIGR03109 596153002433 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 596153002434 EpsI family protein; Region: EpsI_fam; TIGR02914 596153002435 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 596153002436 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 596153002437 active site 596153002438 dimer interface [polypeptide binding]; other site 596153002439 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 596153002440 Ligand Binding Site [chemical binding]; other site 596153002441 Molecular Tunnel; other site 596153002442 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 596153002443 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 596153002444 putative ADP-binding pocket [chemical binding]; other site 596153002445 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 596153002446 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 596153002447 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 596153002448 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 596153002449 active site 596153002450 homodimer interface [polypeptide binding]; other site 596153002451 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 596153002452 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 596153002453 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 596153002454 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 596153002455 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 596153002456 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 596153002457 O-Antigen ligase; Region: Wzy_C; cl04850 596153002458 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 596153002459 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 596153002460 putative active site [active] 596153002461 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 596153002462 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 596153002463 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 596153002464 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 596153002465 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 596153002466 active site 596153002467 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 596153002468 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 596153002469 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 596153002470 TrkA-N domain; Region: TrkA_N; pfam02254 596153002471 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 596153002472 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 596153002473 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 596153002474 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 596153002475 NAD binding site [chemical binding]; other site 596153002476 substrate binding site [chemical binding]; other site 596153002477 homodimer interface [polypeptide binding]; other site 596153002478 active site 596153002479 Sulfatase; Region: Sulfatase; cl17466 596153002480 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 596153002481 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 596153002482 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 596153002483 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 596153002484 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 596153002485 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 596153002486 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 596153002487 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153002488 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 596153002489 acyl-activating enzyme (AAE) consensus motif; other site 596153002490 acyl-activating enzyme (AAE) consensus motif; other site 596153002491 putative AMP binding site [chemical binding]; other site 596153002492 putative active site [active] 596153002493 putative CoA binding site [chemical binding]; other site 596153002494 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 596153002495 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 596153002496 dimer interface [polypeptide binding]; other site 596153002497 active site 596153002498 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 596153002499 catalytic residues [active] 596153002500 substrate binding site [chemical binding]; other site 596153002501 GAF domain; Region: GAF_3; pfam13492 596153002502 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 596153002503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153002504 ATP binding site [chemical binding]; other site 596153002505 Mg2+ binding site [ion binding]; other site 596153002506 G-X-G motif; other site 596153002507 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 596153002508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153002509 active site 596153002510 phosphorylation site [posttranslational modification] 596153002511 intermolecular recognition site; other site 596153002512 dimerization interface [polypeptide binding]; other site 596153002513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153002514 Walker A motif; other site 596153002515 ATP binding site [chemical binding]; other site 596153002516 Walker B motif; other site 596153002517 arginine finger; other site 596153002518 Helix-turn-helix domain; Region: HTH_17; pfam12728 596153002519 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 596153002520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 596153002521 binding surface 596153002522 TPR motif; other site 596153002523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 596153002524 TPR motif; other site 596153002525 binding surface 596153002526 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 596153002527 TPR motif; other site 596153002528 binding surface 596153002529 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 596153002530 TPR motif; other site 596153002531 binding surface 596153002532 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 596153002533 binding surface 596153002534 TPR motif; other site 596153002535 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 596153002536 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 596153002537 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 596153002538 rRNA binding site [nucleotide binding]; other site 596153002539 predicted 30S ribosome binding site; other site 596153002540 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321 596153002541 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 596153002542 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153002543 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 596153002544 acyl-activating enzyme (AAE) consensus motif; other site 596153002545 acyl-activating enzyme (AAE) consensus motif; other site 596153002546 putative AMP binding site [chemical binding]; other site 596153002547 putative active site [active] 596153002548 putative CoA binding site [chemical binding]; other site 596153002549 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 596153002550 FAD binding pocket [chemical binding]; other site 596153002551 conserved FAD binding motif [chemical binding]; other site 596153002552 phosphate binding motif [ion binding]; other site 596153002553 beta-alpha-beta structure motif; other site 596153002554 NAD binding pocket [chemical binding]; other site 596153002555 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 596153002556 PGAP1-like protein; Region: PGAP1; pfam07819 596153002557 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 596153002558 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 596153002559 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 596153002560 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 596153002561 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 596153002562 catalytic residues [active] 596153002563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 596153002564 CreA protein; Region: CreA; pfam05981 596153002565 cyanophycin synthetase; Provisional; Region: PRK14016 596153002566 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 596153002567 ATP-grasp domain; Region: ATP-grasp_4; cl17255 596153002568 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 596153002569 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 596153002570 cyanophycin synthetase; Provisional; Region: PRK14016 596153002571 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 596153002572 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 596153002573 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 596153002574 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 596153002575 Walker A/P-loop; other site 596153002576 ATP binding site [chemical binding]; other site 596153002577 Q-loop/lid; other site 596153002578 ABC transporter signature motif; other site 596153002579 Walker B; other site 596153002580 D-loop; other site 596153002581 H-loop/switch region; other site 596153002582 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 596153002583 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 596153002584 elongation factor G; Reviewed; Region: PRK12740 596153002585 G1 box; other site 596153002586 putative GEF interaction site [polypeptide binding]; other site 596153002587 GTP/Mg2+ binding site [chemical binding]; other site 596153002588 Switch I region; other site 596153002589 G2 box; other site 596153002590 G3 box; other site 596153002591 Switch II region; other site 596153002592 G4 box; other site 596153002593 G5 box; other site 596153002594 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 596153002595 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 596153002596 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 596153002597 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 596153002598 type II secretion system protein F; Region: GspF; TIGR02120 596153002599 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 596153002600 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 596153002601 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 596153002602 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 596153002603 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 596153002604 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 596153002605 type II secretion system protein E; Region: type_II_gspE; TIGR02533 596153002606 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 596153002607 Walker A motif; other site 596153002608 ATP binding site [chemical binding]; other site 596153002609 Walker B motif; other site 596153002610 type II secretion system protein D; Region: type_II_gspD; TIGR02517 596153002611 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 596153002612 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 596153002613 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 596153002614 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 596153002615 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 596153002616 GspL periplasmic domain; Region: GspL_C; cl14909 596153002617 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 596153002618 type II secretion system protein I; Region: gspI; TIGR01707 596153002619 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 596153002620 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 596153002621 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 596153002622 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 596153002623 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 596153002624 cobalamin synthase; Reviewed; Region: cobS; PRK00235 596153002625 threonine dehydratase; Reviewed; Region: PRK09224 596153002626 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 596153002627 tetramer interface [polypeptide binding]; other site 596153002628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153002629 catalytic residue [active] 596153002630 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 596153002631 putative Ile/Val binding site [chemical binding]; other site 596153002632 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 596153002633 putative Ile/Val binding site [chemical binding]; other site 596153002634 OsmC-like protein; Region: OsmC; cl00767 596153002635 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 596153002636 dinuclear metal binding motif [ion binding]; other site 596153002637 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 596153002638 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 596153002639 trimer interface [polypeptide binding]; other site 596153002640 eyelet of channel; other site 596153002641 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 596153002642 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 596153002643 trimer interface [polypeptide binding]; other site 596153002644 eyelet of channel; other site 596153002645 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 596153002646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153002647 dimer interface [polypeptide binding]; other site 596153002648 conserved gate region; other site 596153002649 putative PBP binding loops; other site 596153002650 ABC-ATPase subunit interface; other site 596153002651 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 596153002652 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 596153002653 metal binding site [ion binding]; metal-binding site 596153002654 putative dimer interface [polypeptide binding]; other site 596153002655 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 596153002656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153002657 dimer interface [polypeptide binding]; other site 596153002658 conserved gate region; other site 596153002659 putative PBP binding loops; other site 596153002660 ABC-ATPase subunit interface; other site 596153002661 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 596153002662 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 596153002663 Walker A/P-loop; other site 596153002664 ATP binding site [chemical binding]; other site 596153002665 Q-loop/lid; other site 596153002666 ABC transporter signature motif; other site 596153002667 Walker B; other site 596153002668 D-loop; other site 596153002669 H-loop/switch region; other site 596153002670 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 596153002671 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 596153002672 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 596153002673 Walker A/P-loop; other site 596153002674 ATP binding site [chemical binding]; other site 596153002675 Q-loop/lid; other site 596153002676 ABC transporter signature motif; other site 596153002677 Walker B; other site 596153002678 D-loop; other site 596153002679 H-loop/switch region; other site 596153002680 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 596153002681 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 596153002682 substrate binding site [chemical binding]; other site 596153002683 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 596153002684 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 596153002685 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 596153002686 putative active site [active] 596153002687 transaldolase-like protein; Provisional; Region: PTZ00411 596153002688 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 596153002689 active site 596153002690 dimer interface [polypeptide binding]; other site 596153002691 catalytic residue [active] 596153002692 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 596153002693 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 596153002694 active site 596153002695 dimer interface [polypeptide binding]; other site 596153002696 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 596153002697 dimer interface [polypeptide binding]; other site 596153002698 active site 596153002699 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 596153002700 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 596153002701 ring oligomerisation interface [polypeptide binding]; other site 596153002702 ATP/Mg binding site [chemical binding]; other site 596153002703 stacking interactions; other site 596153002704 hinge regions; other site 596153002705 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 596153002706 oligomerisation interface [polypeptide binding]; other site 596153002707 mobile loop; other site 596153002708 roof hairpin; other site 596153002709 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 596153002710 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 596153002711 active site 596153002712 nucleotide binding site [chemical binding]; other site 596153002713 HIGH motif; other site 596153002714 KMSKS motif; other site 596153002715 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 596153002716 nudix motif; other site 596153002717 S-adenosylmethionine synthetase; Validated; Region: PRK05250 596153002718 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 596153002719 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 596153002720 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 596153002721 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 596153002722 putative acyl-acceptor binding pocket; other site 596153002723 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 596153002724 putative acyl-acceptor binding pocket; other site 596153002725 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153002726 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153002727 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 596153002728 putative dimerization interface [polypeptide binding]; other site 596153002729 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153002730 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153002731 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 596153002732 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 596153002733 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 596153002734 active site 596153002735 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 596153002736 G1 box; other site 596153002737 GTP/Mg2+ binding site [chemical binding]; other site 596153002738 Switch I region; other site 596153002739 G2 box; other site 596153002740 G3 box; other site 596153002741 Switch II region; other site 596153002742 G4 box; other site 596153002743 G5 box; other site 596153002744 Cytochrome c553 [Energy production and conversion]; Region: COG2863 596153002745 Cytochrome c; Region: Cytochrom_C; cl11414 596153002746 ResB-like family; Region: ResB; pfam05140 596153002747 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 596153002748 ResB-like family; Region: ResB; pfam05140 596153002749 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 596153002750 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 596153002751 TMAO/DMSO reductase; Reviewed; Region: PRK05363 596153002752 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 596153002753 Moco binding site; other site 596153002754 metal coordination site [ion binding]; other site 596153002755 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 596153002756 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 596153002757 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 596153002758 diaminopimelate decarboxylase; Region: lysA; TIGR01048 596153002759 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 596153002760 active site 596153002761 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 596153002762 substrate binding site [chemical binding]; other site 596153002763 catalytic residues [active] 596153002764 dimer interface [polypeptide binding]; other site 596153002765 Frataxin-like domain; Region: Frataxin_Cyay; pfam01491 596153002766 putative iron binding site [ion binding]; other site 596153002767 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 596153002768 Transglycosylase; Region: Transgly; pfam00912 596153002769 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 596153002770 Competence protein A; Region: Competence_A; pfam11104 596153002771 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 596153002772 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 596153002773 nucleotide binding site [chemical binding]; other site 596153002774 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 596153002775 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 596153002776 Pilus assembly protein, PilO; Region: PilO; pfam04350 596153002777 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 596153002778 Pilus assembly protein, PilP; Region: PilP; pfam04351 596153002779 AMIN domain; Region: AMIN; pfam11741 596153002780 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 596153002781 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 596153002782 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 596153002783 Putative Ig domain; Region: He_PIG; pfam05345 596153002784 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 596153002785 active site 596153002786 dimer interface [polypeptide binding]; other site 596153002787 metal binding site [ion binding]; metal-binding site 596153002788 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 596153002789 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 596153002790 Zn2+ binding site [ion binding]; other site 596153002791 Mg2+ binding site [ion binding]; other site 596153002792 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 596153002793 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 596153002794 Methyltransferase domain; Region: Methyltransf_31; pfam13847 596153002795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153002796 S-adenosylmethionine binding site [chemical binding]; other site 596153002797 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 596153002798 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 596153002799 tetrameric interface [polypeptide binding]; other site 596153002800 NAD binding site [chemical binding]; other site 596153002801 catalytic residues [active] 596153002802 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153002803 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 596153002804 putative ligand binding site [chemical binding]; other site 596153002805 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153002806 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153002807 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153002808 dimerization interface [polypeptide binding]; other site 596153002809 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 596153002810 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 596153002811 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 596153002812 active site 596153002813 dimer interface [polypeptide binding]; other site 596153002814 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 596153002815 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 596153002816 active site 596153002817 FMN binding site [chemical binding]; other site 596153002818 substrate binding site [chemical binding]; other site 596153002819 3Fe-4S cluster binding site [ion binding]; other site 596153002820 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 596153002821 domain interface; other site 596153002822 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 596153002823 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 596153002824 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 596153002825 substrate binding pocket [chemical binding]; other site 596153002826 membrane-bound complex binding site; other site 596153002827 hinge residues; other site 596153002828 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 596153002829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153002830 dimer interface [polypeptide binding]; other site 596153002831 conserved gate region; other site 596153002832 putative PBP binding loops; other site 596153002833 ABC-ATPase subunit interface; other site 596153002834 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 596153002835 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 596153002836 Walker A/P-loop; other site 596153002837 ATP binding site [chemical binding]; other site 596153002838 Q-loop/lid; other site 596153002839 ABC transporter signature motif; other site 596153002840 Walker B; other site 596153002841 D-loop; other site 596153002842 H-loop/switch region; other site 596153002843 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 596153002844 spermidine synthase; Provisional; Region: PRK00811 596153002845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153002846 S-adenosylmethionine binding site [chemical binding]; other site 596153002847 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 596153002848 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 596153002849 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 596153002850 Walker A/P-loop; other site 596153002851 ATP binding site [chemical binding]; other site 596153002852 Q-loop/lid; other site 596153002853 ABC transporter signature motif; other site 596153002854 Walker B; other site 596153002855 D-loop; other site 596153002856 H-loop/switch region; other site 596153002857 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 596153002858 Permease; Region: Permease; pfam02405 596153002859 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 596153002860 mce related protein; Region: MCE; pfam02470 596153002861 VacJ like lipoprotein; Region: VacJ; cl01073 596153002862 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 596153002863 STAS domain; Region: STAS_2; pfam13466 596153002864 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153002865 PAS domain; Region: PAS_9; pfam13426 596153002866 putative active site [active] 596153002867 heme pocket [chemical binding]; other site 596153002868 PAS domain; Region: PAS; smart00091 596153002869 PAS fold; Region: PAS_4; pfam08448 596153002870 putative active site [active] 596153002871 heme pocket [chemical binding]; other site 596153002872 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153002873 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153002874 metal binding site [ion binding]; metal-binding site 596153002875 active site 596153002876 I-site; other site 596153002877 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 596153002878 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 596153002879 Walker A/P-loop; other site 596153002880 ATP binding site [chemical binding]; other site 596153002881 Q-loop/lid; other site 596153002882 ABC transporter signature motif; other site 596153002883 Walker B; other site 596153002884 D-loop; other site 596153002885 H-loop/switch region; other site 596153002886 ABC-2 type transporter; Region: ABC2_membrane; cl17235 596153002887 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 596153002888 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 596153002889 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 596153002890 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 596153002891 hinge; other site 596153002892 active site 596153002893 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 596153002894 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 596153002895 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 596153002896 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 596153002897 NAD binding site [chemical binding]; other site 596153002898 dimerization interface [polypeptide binding]; other site 596153002899 product binding site; other site 596153002900 substrate binding site [chemical binding]; other site 596153002901 zinc binding site [ion binding]; other site 596153002902 catalytic residues [active] 596153002903 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 596153002904 putative active site [active] 596153002905 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 596153002906 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 596153002907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153002908 homodimer interface [polypeptide binding]; other site 596153002909 catalytic residue [active] 596153002910 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 596153002911 putative active site pocket [active] 596153002912 4-fold oligomerization interface [polypeptide binding]; other site 596153002913 metal binding residues [ion binding]; metal-binding site 596153002914 3-fold/trimer interface [polypeptide binding]; other site 596153002915 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 596153002916 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 596153002917 putative active site [active] 596153002918 oxyanion strand; other site 596153002919 catalytic triad [active] 596153002920 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 596153002921 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 596153002922 catalytic residues [active] 596153002923 Spherulation-specific family 4; Region: Spherulin4; pfam12138 596153002924 Predicted membrane protein [Function unknown]; Region: COG4267 596153002925 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 596153002926 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 596153002927 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 596153002928 GAF domain; Region: GAF_3; pfam13492 596153002929 Tetratricopeptide repeat; Region: TPR_15; pfam13429 596153002930 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 596153002931 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 596153002932 putative active site [active] 596153002933 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 596153002934 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 596153002935 NAD binding site [chemical binding]; other site 596153002936 homodimer interface [polypeptide binding]; other site 596153002937 active site 596153002938 substrate binding site [chemical binding]; other site 596153002939 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 596153002940 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 596153002941 substrate binding site [chemical binding]; other site 596153002942 glutamase interaction surface [polypeptide binding]; other site 596153002943 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 596153002944 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 596153002945 metal binding site [ion binding]; metal-binding site 596153002946 Predicted membrane protein [Function unknown]; Region: COG3671 596153002947 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 596153002948 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 596153002949 active site 596153002950 nucleophile elbow; other site 596153002951 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 596153002952 nucleotide binding site/active site [active] 596153002953 HIT family signature motif; other site 596153002954 catalytic residue [active] 596153002955 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 596153002956 sec-independent translocase; Provisional; Region: tatB; PRK01919 596153002957 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 596153002958 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 596153002959 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 596153002960 protein binding site [polypeptide binding]; other site 596153002961 Uncharacterized conserved protein [Function unknown]; Region: COG0327 596153002962 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 596153002963 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 596153002964 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 596153002965 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 596153002966 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 596153002967 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 596153002968 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 596153002969 [2Fe-2S] cluster binding site [ion binding]; other site 596153002970 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 596153002971 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 596153002972 Qi binding site; other site 596153002973 intrachain domain interface; other site 596153002974 interchain domain interface [polypeptide binding]; other site 596153002975 heme bH binding site [chemical binding]; other site 596153002976 heme bL binding site [chemical binding]; other site 596153002977 Qo binding site; other site 596153002978 interchain domain interface [polypeptide binding]; other site 596153002979 intrachain domain interface; other site 596153002980 Qi binding site; other site 596153002981 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 596153002982 Qo binding site; other site 596153002983 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 596153002984 stringent starvation protein A; Provisional; Region: sspA; PRK09481 596153002985 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 596153002986 C-terminal domain interface [polypeptide binding]; other site 596153002987 putative GSH binding site (G-site) [chemical binding]; other site 596153002988 dimer interface [polypeptide binding]; other site 596153002989 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 596153002990 dimer interface [polypeptide binding]; other site 596153002991 N-terminal domain interface [polypeptide binding]; other site 596153002992 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 596153002993 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 596153002994 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 596153002995 SEC-C motif; Region: SEC-C; pfam02810 596153002996 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 596153002997 heterotetramer interface [polypeptide binding]; other site 596153002998 active site pocket [active] 596153002999 cleavage site 596153003000 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 596153003001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153003002 Walker A motif; other site 596153003003 ATP binding site [chemical binding]; other site 596153003004 Walker B motif; other site 596153003005 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 596153003006 active site 596153003007 8-oxo-dGMP binding site [chemical binding]; other site 596153003008 nudix motif; other site 596153003009 metal binding site [ion binding]; metal-binding site 596153003010 Domain of unknown function (DUF329); Region: DUF329; pfam03884 596153003011 hypothetical protein; Provisional; Region: PRK05287 596153003012 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 596153003013 dephospho-CoA kinase; Region: TIGR00152 596153003014 CoA-binding site [chemical binding]; other site 596153003015 ATP-binding [chemical binding]; other site 596153003016 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 596153003017 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 596153003018 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 596153003019 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 596153003020 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 596153003021 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 596153003022 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 596153003023 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 596153003024 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 596153003025 Walker A motif; other site 596153003026 ATP binding site [chemical binding]; other site 596153003027 Walker B motif; other site 596153003028 putative transposase OrfB; Reviewed; Region: PHA02517 596153003029 HTH-like domain; Region: HTH_21; pfam13276 596153003030 Integrase core domain; Region: rve; pfam00665 596153003031 Integrase core domain; Region: rve_3; cl15866 596153003032 Transposase; Region: HTH_Tnp_1; cl17663 596153003033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153003034 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 596153003035 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 596153003036 active site 596153003037 DNA binding site [nucleotide binding] 596153003038 Int/Topo IB signature motif; other site 596153003039 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 596153003040 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 596153003041 substrate binding pocket [chemical binding]; other site 596153003042 chain length determination region; other site 596153003043 substrate-Mg2+ binding site; other site 596153003044 catalytic residues [active] 596153003045 aspartate-rich region 1; other site 596153003046 active site lid residues [active] 596153003047 aspartate-rich region 2; other site 596153003048 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 596153003049 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 596153003050 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 596153003051 GTPase CgtA; Reviewed; Region: obgE; PRK12299 596153003052 GTP1/OBG; Region: GTP1_OBG; pfam01018 596153003053 Obg GTPase; Region: Obg; cd01898 596153003054 G1 box; other site 596153003055 GTP/Mg2+ binding site [chemical binding]; other site 596153003056 Switch I region; other site 596153003057 G2 box; other site 596153003058 G3 box; other site 596153003059 Switch II region; other site 596153003060 G4 box; other site 596153003061 G5 box; other site 596153003062 gamma-glutamyl kinase; Provisional; Region: PRK05429 596153003063 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 596153003064 nucleotide binding site [chemical binding]; other site 596153003065 homotetrameric interface [polypeptide binding]; other site 596153003066 putative phosphate binding site [ion binding]; other site 596153003067 putative allosteric binding site; other site 596153003068 PUA domain; Region: PUA; pfam01472 596153003069 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 596153003070 putative active site [active] 596153003071 Ap4A binding site [chemical binding]; other site 596153003072 nudix motif; other site 596153003073 putative metal binding site [ion binding]; other site 596153003074 prolyl-tRNA synthetase; Provisional; Region: PRK09194 596153003075 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 596153003076 dimer interface [polypeptide binding]; other site 596153003077 motif 1; other site 596153003078 active site 596153003079 motif 2; other site 596153003080 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 596153003081 putative deacylase active site [active] 596153003082 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 596153003083 active site 596153003084 motif 3; other site 596153003085 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 596153003086 anticodon binding site; other site 596153003087 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 596153003088 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 596153003089 N-acetyl-D-glucosamine binding site [chemical binding]; other site 596153003090 catalytic residue [active] 596153003091 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 596153003092 Domain of unknown function DUF21; Region: DUF21; pfam01595 596153003093 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 596153003094 Transporter associated domain; Region: CorC_HlyC; smart01091 596153003095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153003096 Walker A motif; other site 596153003097 ATP binding site [chemical binding]; other site 596153003098 Walker B motif; other site 596153003099 arginine finger; other site 596153003100 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 596153003101 putative GSH binding site [chemical binding]; other site 596153003102 catalytic residues [active] 596153003103 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 596153003104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153003105 S-adenosylmethionine binding site [chemical binding]; other site 596153003106 peptide chain release factor 1; Validated; Region: prfA; PRK00591 596153003107 This domain is found in peptide chain release factors; Region: PCRF; smart00937 596153003108 RF-1 domain; Region: RF-1; pfam00472 596153003109 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 596153003110 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 596153003111 tRNA; other site 596153003112 putative tRNA binding site [nucleotide binding]; other site 596153003113 putative NADP binding site [chemical binding]; other site 596153003114 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 596153003115 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 596153003116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153003117 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153003118 dimerization interface [polypeptide binding]; other site 596153003119 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153003120 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 596153003121 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 596153003122 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 596153003123 Mechanosensitive ion channel; Region: MS_channel; pfam00924 596153003124 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 596153003125 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 596153003126 putative active site [active] 596153003127 catalytic site [active] 596153003128 putative metal binding site [ion binding]; other site 596153003129 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 596153003130 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 596153003131 Walker A/P-loop; other site 596153003132 ATP binding site [chemical binding]; other site 596153003133 Q-loop/lid; other site 596153003134 ABC transporter signature motif; other site 596153003135 Walker B; other site 596153003136 D-loop; other site 596153003137 H-loop/switch region; other site 596153003138 TOBE domain; Region: TOBE_2; pfam08402 596153003139 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 596153003140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153003141 dimer interface [polypeptide binding]; other site 596153003142 conserved gate region; other site 596153003143 putative PBP binding loops; other site 596153003144 ABC-ATPase subunit interface; other site 596153003145 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 596153003146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153003147 dimer interface [polypeptide binding]; other site 596153003148 conserved gate region; other site 596153003149 ABC-ATPase subunit interface; other site 596153003150 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 596153003151 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 596153003152 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 596153003153 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 596153003154 ligand binding site [chemical binding]; other site 596153003155 NAD binding site [chemical binding]; other site 596153003156 tetramer interface [polypeptide binding]; other site 596153003157 catalytic site [active] 596153003158 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 596153003159 L-serine binding site [chemical binding]; other site 596153003160 ACT domain interface; other site 596153003161 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 596153003162 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 596153003163 FAD binding domain; Region: FAD_binding_4; pfam01565 596153003164 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 596153003165 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 596153003166 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 596153003167 Cysteine-rich domain; Region: CCG; pfam02754 596153003168 Cysteine-rich domain; Region: CCG; pfam02754 596153003169 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 596153003170 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 596153003171 HIT family signature motif; other site 596153003172 catalytic residue [active] 596153003173 Protein of unknown function (DUF971); Region: DUF971; pfam06155 596153003174 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 596153003175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153003176 S-adenosylmethionine binding site [chemical binding]; other site 596153003177 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 596153003178 SCP-2 sterol transfer family; Region: SCP2; pfam02036 596153003179 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 596153003180 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 596153003181 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 596153003182 Na binding site [ion binding]; other site 596153003183 putative glycosylation site [posttranslational modification]; other site 596153003184 putative glycosylation site [posttranslational modification]; other site 596153003185 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 596153003186 Uncharacterized conserved protein [Function unknown]; Region: COG2928 596153003187 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 596153003188 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 596153003189 dimer interface [polypeptide binding]; other site 596153003190 anticodon binding site; other site 596153003191 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 596153003192 homodimer interface [polypeptide binding]; other site 596153003193 motif 1; other site 596153003194 active site 596153003195 motif 2; other site 596153003196 GAD domain; Region: GAD; pfam02938 596153003197 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 596153003198 motif 3; other site 596153003199 dihydroneopterin triphosphate pyrophosphatase; Provisional; Region: nudB; PRK09438 596153003200 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 596153003201 putative catalytic site [active] 596153003202 putative metal binding site [ion binding]; other site 596153003203 putative phosphate binding site [ion binding]; other site 596153003204 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 596153003205 putative active site [active] 596153003206 catalytic site [active] 596153003207 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 596153003208 putative active site [active] 596153003209 catalytic site [active] 596153003210 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 596153003211 active site 596153003212 Sensors of blue-light using FAD; Region: BLUF; smart01034 596153003213 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 596153003214 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 596153003215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153003216 dimer interface [polypeptide binding]; other site 596153003217 phosphorylation site [posttranslational modification] 596153003218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153003219 ATP binding site [chemical binding]; other site 596153003220 G-X-G motif; other site 596153003221 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 596153003222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153003223 active site 596153003224 phosphorylation site [posttranslational modification] 596153003225 intermolecular recognition site; other site 596153003226 dimerization interface [polypeptide binding]; other site 596153003227 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 596153003228 DNA binding residues [nucleotide binding] 596153003229 Cytochrome c [Energy production and conversion]; Region: COG3258 596153003230 Cytochrome c; Region: Cytochrom_C; pfam00034 596153003231 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 596153003232 amidase; Provisional; Region: PRK07042 596153003233 Amidase; Region: Amidase; cl11426 596153003234 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 596153003235 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 596153003236 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 596153003237 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 596153003238 Walker A/P-loop; other site 596153003239 ATP binding site [chemical binding]; other site 596153003240 Q-loop/lid; other site 596153003241 ABC transporter signature motif; other site 596153003242 Walker B; other site 596153003243 D-loop; other site 596153003244 H-loop/switch region; other site 596153003245 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 596153003246 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 596153003247 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 596153003248 Walker A/P-loop; other site 596153003249 ATP binding site [chemical binding]; other site 596153003250 Q-loop/lid; other site 596153003251 ABC transporter signature motif; other site 596153003252 Walker B; other site 596153003253 D-loop; other site 596153003254 H-loop/switch region; other site 596153003255 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 596153003256 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 596153003257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153003258 dimer interface [polypeptide binding]; other site 596153003259 conserved gate region; other site 596153003260 putative PBP binding loops; other site 596153003261 ABC-ATPase subunit interface; other site 596153003262 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 596153003263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153003264 dimer interface [polypeptide binding]; other site 596153003265 conserved gate region; other site 596153003266 putative PBP binding loops; other site 596153003267 ABC-ATPase subunit interface; other site 596153003268 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 596153003269 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 596153003270 putative active site [active] 596153003271 catalytic residue [active] 596153003272 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 596153003273 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 596153003274 5S rRNA interface [nucleotide binding]; other site 596153003275 CTC domain interface [polypeptide binding]; other site 596153003276 L16 interface [polypeptide binding]; other site 596153003277 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 596153003278 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 596153003279 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 596153003280 active site 596153003281 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 596153003282 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 596153003283 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 596153003284 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 596153003285 binding surface 596153003286 TPR motif; other site 596153003287 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 596153003288 binding surface 596153003289 TPR motif; other site 596153003290 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 596153003291 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 596153003292 DNA binding site [nucleotide binding] 596153003293 catalytic residue [active] 596153003294 H2TH interface [polypeptide binding]; other site 596153003295 putative catalytic residues [active] 596153003296 turnover-facilitating residue; other site 596153003297 intercalation triad [nucleotide binding]; other site 596153003298 8OG recognition residue [nucleotide binding]; other site 596153003299 putative reading head residues; other site 596153003300 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 596153003301 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 596153003302 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 596153003303 Dynamin family; Region: Dynamin_N; pfam00350 596153003304 G1 box; other site 596153003305 GTP/Mg2+ binding site [chemical binding]; other site 596153003306 G2 box; other site 596153003307 Switch I region; other site 596153003308 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 596153003309 G3 box; other site 596153003310 Switch II region; other site 596153003311 GTP/Mg2+ binding site [chemical binding]; other site 596153003312 G4 box; other site 596153003313 G5 box; other site 596153003314 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 596153003315 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 596153003316 minor groove reading motif; other site 596153003317 helix-hairpin-helix signature motif; other site 596153003318 substrate binding pocket [chemical binding]; other site 596153003319 active site 596153003320 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 596153003321 DNA binding and oxoG recognition site [nucleotide binding] 596153003322 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 596153003323 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 596153003324 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 596153003325 Walker A/P-loop; other site 596153003326 ATP binding site [chemical binding]; other site 596153003327 Q-loop/lid; other site 596153003328 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 596153003329 ABC transporter signature motif; other site 596153003330 Walker B; other site 596153003331 D-loop; other site 596153003332 H-loop/switch region; other site 596153003333 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 596153003334 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 596153003335 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 596153003336 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 596153003337 hypothetical protein; Validated; Region: PRK06201 596153003338 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 596153003339 glycerate dehydrogenase; Provisional; Region: PRK06487 596153003340 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 596153003341 putative ligand binding site [chemical binding]; other site 596153003342 putative NAD binding site [chemical binding]; other site 596153003343 catalytic site [active] 596153003344 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153003345 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153003346 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 596153003347 dimerization interface [polypeptide binding]; other site 596153003348 aspartate aminotransferase; Provisional; Region: PRK05764 596153003349 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 596153003350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153003351 homodimer interface [polypeptide binding]; other site 596153003352 catalytic residue [active] 596153003353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153003354 dimer interface [polypeptide binding]; other site 596153003355 conserved gate region; other site 596153003356 putative PBP binding loops; other site 596153003357 ABC-ATPase subunit interface; other site 596153003358 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 596153003359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153003360 dimer interface [polypeptide binding]; other site 596153003361 conserved gate region; other site 596153003362 putative PBP binding loops; other site 596153003363 ABC-ATPase subunit interface; other site 596153003364 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 596153003365 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 596153003366 Walker A/P-loop; other site 596153003367 ATP binding site [chemical binding]; other site 596153003368 Q-loop/lid; other site 596153003369 ABC transporter signature motif; other site 596153003370 Walker B; other site 596153003371 D-loop; other site 596153003372 H-loop/switch region; other site 596153003373 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 596153003374 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 596153003375 substrate binding pocket [chemical binding]; other site 596153003376 membrane-bound complex binding site; other site 596153003377 hinge residues; other site 596153003378 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 596153003379 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 596153003380 substrate binding pocket [chemical binding]; other site 596153003381 membrane-bound complex binding site; other site 596153003382 hinge residues; other site 596153003383 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 596153003384 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 596153003385 lipoyl-biotinyl attachment site [posttranslational modification]; other site 596153003386 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 596153003387 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 596153003388 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 596153003389 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 596153003390 putative active site [active] 596153003391 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 596153003392 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 596153003393 carboxyltransferase (CT) interaction site; other site 596153003394 biotinylation site [posttranslational modification]; other site 596153003395 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 596153003396 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 596153003397 ATP-grasp domain; Region: ATP-grasp_4; cl17255 596153003398 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 596153003399 Sporulation related domain; Region: SPOR; pfam05036 596153003400 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 596153003401 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 596153003402 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 596153003403 FeS/SAM binding site; other site 596153003404 HemN C-terminal domain; Region: HemN_C; pfam06969 596153003405 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 596153003406 active site 596153003407 dimerization interface [polypeptide binding]; other site 596153003408 ribonuclease PH; Reviewed; Region: rph; PRK00173 596153003409 Ribonuclease PH; Region: RNase_PH_bact; cd11362 596153003410 hexamer interface [polypeptide binding]; other site 596153003411 active site 596153003412 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 596153003413 Protein phosphatase 2C; Region: PP2C; pfam00481 596153003414 active site 596153003415 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 596153003416 Catalytic domain of Protein Kinases; Region: PKc; cd00180 596153003417 active site 596153003418 ATP binding site [chemical binding]; other site 596153003419 substrate binding site [chemical binding]; other site 596153003420 activation loop (A-loop); other site 596153003421 hypothetical protein; Provisional; Region: PRK11820 596153003422 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 596153003423 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 596153003424 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 596153003425 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 596153003426 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 596153003427 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 596153003428 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 596153003429 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 596153003430 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 596153003431 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 596153003432 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 596153003433 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 596153003434 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 596153003435 Walker A motif; other site 596153003436 ATP binding site [chemical binding]; other site 596153003437 Walker B motif; other site 596153003438 arginine finger; other site 596153003439 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 596153003440 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 596153003441 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 596153003442 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 596153003443 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 596153003444 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 596153003445 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 596153003446 catalytic site [active] 596153003447 G-X2-G-X-G-K; other site 596153003448 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 596153003449 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 596153003450 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 596153003451 Zn2+ binding site [ion binding]; other site 596153003452 Mg2+ binding site [ion binding]; other site 596153003453 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 596153003454 synthetase active site [active] 596153003455 NTP binding site [chemical binding]; other site 596153003456 metal binding site [ion binding]; metal-binding site 596153003457 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 596153003458 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 596153003459 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 596153003460 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 596153003461 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 596153003462 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 596153003463 16S/18S rRNA binding site [nucleotide binding]; other site 596153003464 S13e-L30e interaction site [polypeptide binding]; other site 596153003465 25S rRNA binding site [nucleotide binding]; other site 596153003466 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 596153003467 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 596153003468 RNase E interface [polypeptide binding]; other site 596153003469 trimer interface [polypeptide binding]; other site 596153003470 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 596153003471 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 596153003472 RNase E interface [polypeptide binding]; other site 596153003473 trimer interface [polypeptide binding]; other site 596153003474 active site 596153003475 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 596153003476 putative nucleic acid binding region [nucleotide binding]; other site 596153003477 G-X-X-G motif; other site 596153003478 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 596153003479 RNA binding site [nucleotide binding]; other site 596153003480 domain interface; other site 596153003481 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 596153003482 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 596153003483 NAD(P) binding site [chemical binding]; other site 596153003484 triosephosphate isomerase; Provisional; Region: PRK14567 596153003485 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 596153003486 substrate binding site [chemical binding]; other site 596153003487 dimer interface [polypeptide binding]; other site 596153003488 catalytic triad [active] 596153003489 Preprotein translocase SecG subunit; Region: SecG; pfam03840 596153003490 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 596153003491 NADH dehydrogenase subunit B; Validated; Region: PRK06411 596153003492 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 596153003493 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 596153003494 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 596153003495 NADH dehydrogenase subunit D; Validated; Region: PRK06075 596153003496 NADH dehydrogenase subunit E; Validated; Region: PRK07539 596153003497 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 596153003498 putative dimer interface [polypeptide binding]; other site 596153003499 [2Fe-2S] cluster binding site [ion binding]; other site 596153003500 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 596153003501 SLBB domain; Region: SLBB; pfam10531 596153003502 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 596153003503 NADH dehydrogenase subunit G; Validated; Region: PRK09129 596153003504 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 596153003505 catalytic loop [active] 596153003506 iron binding site [ion binding]; other site 596153003507 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 596153003508 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 596153003509 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 596153003510 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 596153003511 4Fe-4S binding domain; Region: Fer4; pfam00037 596153003512 4Fe-4S binding domain; Region: Fer4; pfam00037 596153003513 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 596153003514 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 596153003515 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 596153003516 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 596153003517 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 596153003518 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 596153003519 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 596153003520 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 596153003521 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 596153003522 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 596153003523 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 596153003524 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 596153003525 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 596153003526 glutamate dehydrogenase; Provisional; Region: PRK09414 596153003527 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 596153003528 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 596153003529 NAD(P) binding site [chemical binding]; other site 596153003530 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 596153003531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153003532 ATP binding site [chemical binding]; other site 596153003533 Mg2+ binding site [ion binding]; other site 596153003534 G-X-G motif; other site 596153003535 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 596153003536 ATP binding site [chemical binding]; other site 596153003537 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 596153003538 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 596153003539 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 596153003540 guanine deaminase; Provisional; Region: PRK09228 596153003541 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 596153003542 active site 596153003543 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 596153003544 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153003545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153003546 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153003547 dimerization interface [polypeptide binding]; other site 596153003548 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 596153003549 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 596153003550 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 596153003551 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 596153003552 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 596153003553 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 596153003554 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 596153003555 AMIN domain; Region: AMIN; pfam11741 596153003556 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 596153003557 active site 596153003558 metal binding site [ion binding]; metal-binding site 596153003559 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 596153003560 Predicted permeases [General function prediction only]; Region: COG0679 596153003561 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153003562 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 596153003563 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 596153003564 active site 596153003565 Int/Topo IB signature motif; other site 596153003566 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153003567 PAS domain; Region: PAS_9; pfam13426 596153003568 putative active site [active] 596153003569 heme pocket [chemical binding]; other site 596153003570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153003571 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 596153003572 EAL domain; Region: EAL; pfam00563 596153003573 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 596153003574 EAL domain; Region: EAL; pfam00563 596153003575 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 596153003576 dinuclear metal binding motif [ion binding]; other site 596153003577 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 596153003578 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 596153003579 trimer interface [polypeptide binding]; other site 596153003580 putative metal binding site [ion binding]; other site 596153003581 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 596153003582 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 596153003583 dimerization interface [polypeptide binding]; other site 596153003584 domain crossover interface; other site 596153003585 redox-dependent activation switch; other site 596153003586 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 596153003587 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 596153003588 substrate binding pocket [chemical binding]; other site 596153003589 membrane-bound complex binding site; other site 596153003590 hinge residues; other site 596153003591 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 596153003592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153003593 dimer interface [polypeptide binding]; other site 596153003594 conserved gate region; other site 596153003595 putative PBP binding loops; other site 596153003596 ABC-ATPase subunit interface; other site 596153003597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153003598 dimer interface [polypeptide binding]; other site 596153003599 conserved gate region; other site 596153003600 putative PBP binding loops; other site 596153003601 ABC-ATPase subunit interface; other site 596153003602 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 596153003603 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 596153003604 Walker A/P-loop; other site 596153003605 ATP binding site [chemical binding]; other site 596153003606 Q-loop/lid; other site 596153003607 ABC transporter signature motif; other site 596153003608 Walker B; other site 596153003609 D-loop; other site 596153003610 H-loop/switch region; other site 596153003611 Septum formation initiator; Region: DivIC; cl17659 596153003612 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 596153003613 enolase; Provisional; Region: eno; PRK00077 596153003614 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 596153003615 dimer interface [polypeptide binding]; other site 596153003616 metal binding site [ion binding]; metal-binding site 596153003617 substrate binding pocket [chemical binding]; other site 596153003618 Uncharacterized conserved protein [Function unknown]; Region: COG5470 596153003619 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 596153003620 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 596153003621 CTP synthetase; Validated; Region: pyrG; PRK05380 596153003622 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 596153003623 Catalytic site [active] 596153003624 active site 596153003625 UTP binding site [chemical binding]; other site 596153003626 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 596153003627 active site 596153003628 putative oxyanion hole; other site 596153003629 catalytic triad [active] 596153003630 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 596153003631 Flavoprotein; Region: Flavoprotein; pfam02441 596153003632 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 596153003633 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 596153003634 trimer interface [polypeptide binding]; other site 596153003635 active site 596153003636 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 596153003637 Uncharacterized conserved protein [Function unknown]; Region: COG2850 596153003638 Cupin-like domain; Region: Cupin_8; pfam13621 596153003639 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 596153003640 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 596153003641 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 596153003642 dihydrodipicolinate synthase; Region: dapA; TIGR00674 596153003643 dimer interface [polypeptide binding]; other site 596153003644 active site 596153003645 catalytic residue [active] 596153003646 Methyltransferase domain; Region: Methyltransf_23; pfam13489 596153003647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153003648 S-adenosylmethionine binding site [chemical binding]; other site 596153003649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153003650 Major Facilitator Superfamily; Region: MFS_1; pfam07690 596153003651 putative substrate translocation pore; other site 596153003652 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 596153003653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153003654 ATP binding site [chemical binding]; other site 596153003655 Mg2+ binding site [ion binding]; other site 596153003656 G-X-G motif; other site 596153003657 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 596153003658 anchoring element; other site 596153003659 dimer interface [polypeptide binding]; other site 596153003660 ATP binding site [chemical binding]; other site 596153003661 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 596153003662 active site 596153003663 metal binding site [ion binding]; metal-binding site 596153003664 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 596153003665 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 596153003666 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 596153003667 CAP-like domain; other site 596153003668 active site 596153003669 primary dimer interface [polypeptide binding]; other site 596153003670 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 596153003671 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 596153003672 homotrimer interaction site [polypeptide binding]; other site 596153003673 putative active site [active] 596153003674 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 596153003675 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 596153003676 Competence protein; Region: Competence; pfam03772 596153003677 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 596153003678 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 596153003679 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 596153003680 tetramerization interface [polypeptide binding]; other site 596153003681 NAD(P) binding site [chemical binding]; other site 596153003682 catalytic residues [active] 596153003683 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 596153003684 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 596153003685 active site residue [active] 596153003686 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 596153003687 active site residue [active] 596153003688 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 596153003689 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 596153003690 [2Fe-2S] cluster binding site [ion binding]; other site 596153003691 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 596153003692 alpha subunit interface [polypeptide binding]; other site 596153003693 active site 596153003694 substrate binding site [chemical binding]; other site 596153003695 Fe binding site [ion binding]; other site 596153003696 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 596153003697 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 596153003698 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 596153003699 substrate binding pocket [chemical binding]; other site 596153003700 chain length determination region; other site 596153003701 substrate-Mg2+ binding site; other site 596153003702 catalytic residues [active] 596153003703 aspartate-rich region 1; other site 596153003704 active site lid residues [active] 596153003705 aspartate-rich region 2; other site 596153003706 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 596153003707 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 596153003708 TPP-binding site; other site 596153003709 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 596153003710 PYR/PP interface [polypeptide binding]; other site 596153003711 dimer interface [polypeptide binding]; other site 596153003712 TPP binding site [chemical binding]; other site 596153003713 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 596153003714 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 596153003715 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 596153003716 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 596153003717 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 596153003718 ATP binding site [chemical binding]; other site 596153003719 putative Mg++ binding site [ion binding]; other site 596153003720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 596153003721 nucleotide binding region [chemical binding]; other site 596153003722 ATP-binding site [chemical binding]; other site 596153003723 DEAD/H associated; Region: DEAD_assoc; pfam08494 596153003724 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 596153003725 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 596153003726 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 596153003727 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 596153003728 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 596153003729 active site 596153003730 dimerization interface [polypeptide binding]; other site 596153003731 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 596153003732 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 596153003733 serine O-acetyltransferase; Region: cysE; TIGR01172 596153003734 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 596153003735 trimer interface [polypeptide binding]; other site 596153003736 active site 596153003737 substrate binding site [chemical binding]; other site 596153003738 CoA binding site [chemical binding]; other site 596153003739 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 596153003740 putative FMN binding site [chemical binding]; other site 596153003741 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 596153003742 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 596153003743 tetramer interface [polypeptide binding]; other site 596153003744 catalytic Zn binding site [ion binding]; other site 596153003745 NADP binding site [chemical binding]; other site 596153003746 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 596153003747 MPT binding site; other site 596153003748 trimer interface [polypeptide binding]; other site 596153003749 Protein of unknown function (DUF615); Region: DUF615; pfam04751 596153003750 peptidase PmbA; Provisional; Region: PRK11040 596153003751 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 596153003752 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 596153003753 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 596153003754 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 596153003755 LexA repressor; Validated; Region: PRK00215 596153003756 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 596153003757 Catalytic site [active] 596153003758 Transposase; Region: HTH_Tnp_1; cl17663 596153003759 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153003760 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 596153003761 AAA ATPase domain; Region: AAA_16; pfam13191 596153003762 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 596153003763 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 596153003764 ATP binding site [chemical binding]; other site 596153003765 putative Mg++ binding site [ion binding]; other site 596153003766 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 596153003767 nucleotide binding region [chemical binding]; other site 596153003768 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 596153003769 Fumarase C-terminus; Region: Fumerase_C; pfam05683 596153003770 fumarate hydratase; Reviewed; Region: fumC; PRK00485 596153003771 Class II fumarases; Region: Fumarase_classII; cd01362 596153003772 active site 596153003773 tetramer interface [polypeptide binding]; other site 596153003774 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 596153003775 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 596153003776 ligand binding site [chemical binding]; other site 596153003777 flexible hinge region; other site 596153003778 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 596153003779 non-specific DNA interactions [nucleotide binding]; other site 596153003780 DNA binding site [nucleotide binding] 596153003781 sequence specific DNA binding site [nucleotide binding]; other site 596153003782 putative cAMP binding site [chemical binding]; other site 596153003783 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 596153003784 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 596153003785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153003786 dimer interface [polypeptide binding]; other site 596153003787 conserved gate region; other site 596153003788 putative PBP binding loops; other site 596153003789 ABC-ATPase subunit interface; other site 596153003790 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 596153003791 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 596153003792 Walker A/P-loop; other site 596153003793 ATP binding site [chemical binding]; other site 596153003794 Q-loop/lid; other site 596153003795 ABC transporter signature motif; other site 596153003796 Walker B; other site 596153003797 D-loop; other site 596153003798 H-loop/switch region; other site 596153003799 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 596153003800 acetyl-CoA synthetase; Provisional; Region: PRK00174 596153003801 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 596153003802 active site 596153003803 CoA binding site [chemical binding]; other site 596153003804 acyl-activating enzyme (AAE) consensus motif; other site 596153003805 AMP binding site [chemical binding]; other site 596153003806 acetate binding site [chemical binding]; other site 596153003807 von Willebrand factor type A domain; Region: VWA_2; pfam13519 596153003808 metal ion-dependent adhesion site (MIDAS); other site 596153003809 Protein of unknown function DUF58; Region: DUF58; pfam01882 596153003810 MoxR-like ATPases [General function prediction only]; Region: COG0714 596153003811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153003812 Walker A motif; other site 596153003813 ATP binding site [chemical binding]; other site 596153003814 Walker B motif; other site 596153003815 arginine finger; other site 596153003816 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 596153003817 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 596153003818 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 596153003819 dimerization interface [polypeptide binding]; other site 596153003820 putative DNA binding site [nucleotide binding]; other site 596153003821 putative Zn2+ binding site [ion binding]; other site 596153003822 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 596153003823 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 596153003824 active site 596153003825 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 596153003826 putative active site [active] 596153003827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 596153003828 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 596153003829 type II secretion system protein E; Region: type_II_gspE; TIGR02533 596153003830 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 596153003831 Walker A motif; other site 596153003832 ATP binding site [chemical binding]; other site 596153003833 Walker B motif; other site 596153003834 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 596153003835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 596153003836 short chain dehydrogenase; Provisional; Region: PRK08339 596153003837 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 596153003838 putative NAD(P) binding site [chemical binding]; other site 596153003839 putative active site [active] 596153003840 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 596153003841 PAS fold; Region: PAS_7; pfam12860 596153003842 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153003843 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153003844 metal binding site [ion binding]; metal-binding site 596153003845 active site 596153003846 I-site; other site 596153003847 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 596153003848 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 596153003849 EamA-like transporter family; Region: EamA; pfam00892 596153003850 EamA-like transporter family; Region: EamA; pfam00892 596153003851 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 596153003852 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 596153003853 NADP binding site [chemical binding]; other site 596153003854 dimer interface [polypeptide binding]; other site 596153003855 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 596153003856 nudix motif; other site 596153003857 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153003858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153003859 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 596153003860 putative dimerization interface [polypeptide binding]; other site 596153003861 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 596153003862 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 596153003863 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 596153003864 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 596153003865 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 596153003866 PhoU domain; Region: PhoU; pfam01895 596153003867 PhoU domain; Region: PhoU; pfam01895 596153003868 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 596153003869 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 596153003870 active site 596153003871 metal binding site [ion binding]; metal-binding site 596153003872 hexamer interface [polypeptide binding]; other site 596153003873 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 596153003874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 596153003875 Walker A/P-loop; other site 596153003876 ATP binding site [chemical binding]; other site 596153003877 Q-loop/lid; other site 596153003878 ABC transporter signature motif; other site 596153003879 Walker B; other site 596153003880 D-loop; other site 596153003881 H-loop/switch region; other site 596153003882 TOBE domain; Region: TOBE_2; pfam08402 596153003883 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 596153003884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153003885 dimer interface [polypeptide binding]; other site 596153003886 conserved gate region; other site 596153003887 putative PBP binding loops; other site 596153003888 ABC-ATPase subunit interface; other site 596153003889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153003890 dimer interface [polypeptide binding]; other site 596153003891 conserved gate region; other site 596153003892 putative PBP binding loops; other site 596153003893 ABC-ATPase subunit interface; other site 596153003894 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 596153003895 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 596153003896 Transcriptional regulators [Transcription]; Region: PurR; COG1609 596153003897 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 596153003898 DNA binding site [nucleotide binding] 596153003899 domain linker motif; other site 596153003900 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 596153003901 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 596153003902 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 596153003903 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 596153003904 active site 596153003905 HIGH motif; other site 596153003906 nucleotide binding site [chemical binding]; other site 596153003907 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 596153003908 active site 596153003909 KMSKS motif; other site 596153003910 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 596153003911 tRNA binding surface [nucleotide binding]; other site 596153003912 anticodon binding site; other site 596153003913 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 596153003914 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 596153003915 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 596153003916 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 596153003917 active site 596153003918 Riboflavin kinase; Region: Flavokinase; smart00904 596153003919 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 596153003920 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 596153003921 active site 596153003922 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 596153003923 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 596153003924 active site 596153003925 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 596153003926 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153003927 active site 596153003928 Protein of unknown function, DUF480; Region: DUF480; pfam04337 596153003929 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 596153003930 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 596153003931 active site 596153003932 substrate binding site [chemical binding]; other site 596153003933 cosubstrate binding site; other site 596153003934 catalytic site [active] 596153003935 16S rRNA methyltransferase B; Provisional; Region: PRK14901 596153003936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153003937 S-adenosylmethionine binding site [chemical binding]; other site 596153003938 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 596153003939 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 596153003940 thioredoxin reductase; Provisional; Region: PRK10262 596153003941 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 596153003942 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 596153003943 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 596153003944 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 596153003945 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 596153003946 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 596153003947 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 596153003948 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 596153003949 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 596153003950 ligand binding site [chemical binding]; other site 596153003951 active site 596153003952 recombination factor protein RarA; Reviewed; Region: PRK13342 596153003953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153003954 Walker A motif; other site 596153003955 ATP binding site [chemical binding]; other site 596153003956 Walker B motif; other site 596153003957 arginine finger; other site 596153003958 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 596153003959 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 596153003960 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 596153003961 TM-ABC transporter signature motif; other site 596153003962 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 596153003963 TM-ABC transporter signature motif; other site 596153003964 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 596153003965 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 596153003966 Walker A/P-loop; other site 596153003967 ATP binding site [chemical binding]; other site 596153003968 Q-loop/lid; other site 596153003969 ABC transporter signature motif; other site 596153003970 Walker B; other site 596153003971 D-loop; other site 596153003972 H-loop/switch region; other site 596153003973 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 596153003974 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 596153003975 Walker A/P-loop; other site 596153003976 ATP binding site [chemical binding]; other site 596153003977 Q-loop/lid; other site 596153003978 ABC transporter signature motif; other site 596153003979 Walker B; other site 596153003980 D-loop; other site 596153003981 H-loop/switch region; other site 596153003982 Protein of unknown function, DUF486; Region: DUF486; pfam04342 596153003983 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 596153003984 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 596153003985 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 596153003986 TM2 domain; Region: TM2; pfam05154 596153003987 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 596153003988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 596153003989 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 596153003990 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 596153003991 RimM N-terminal domain; Region: RimM; pfam01782 596153003992 PRC-barrel domain; Region: PRC; pfam05239 596153003993 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 596153003994 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 596153003995 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 596153003996 putative active site [active] 596153003997 putative CoA binding site [chemical binding]; other site 596153003998 nudix motif; other site 596153003999 metal binding site [ion binding]; metal-binding site 596153004000 CobD/Cbib protein; Region: CobD_Cbib; cl00561 596153004001 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 596153004002 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 596153004003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153004004 homodimer interface [polypeptide binding]; other site 596153004005 catalytic residue [active] 596153004006 putative transporter; Provisional; Region: PRK11660 596153004007 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 596153004008 Sulfate transporter family; Region: Sulfate_transp; pfam00916 596153004009 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 596153004010 GTPase RsgA; Reviewed; Region: PRK00098 596153004011 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 596153004012 RNA binding site [nucleotide binding]; other site 596153004013 homodimer interface [polypeptide binding]; other site 596153004014 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 596153004015 GTPase/Zn-binding domain interface [polypeptide binding]; other site 596153004016 GTP/Mg2+ binding site [chemical binding]; other site 596153004017 G4 box; other site 596153004018 G5 box; other site 596153004019 G1 box; other site 596153004020 Switch I region; other site 596153004021 G2 box; other site 596153004022 G3 box; other site 596153004023 Switch II region; other site 596153004024 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 596153004025 aromatic arch; other site 596153004026 DCoH dimer interaction site [polypeptide binding]; other site 596153004027 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 596153004028 DCoH tetramer interaction site [polypeptide binding]; other site 596153004029 substrate binding site [chemical binding]; other site 596153004030 Peptidase family M48; Region: Peptidase_M48; cl12018 596153004031 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 596153004032 catalytic site [active] 596153004033 putative active site [active] 596153004034 putative substrate binding site [chemical binding]; other site 596153004035 dimer interface [polypeptide binding]; other site 596153004036 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 596153004037 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 596153004038 dimerization interface [polypeptide binding]; other site 596153004039 ligand binding site [chemical binding]; other site 596153004040 helicase 45; Provisional; Region: PTZ00424 596153004041 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 596153004042 ATP binding site [chemical binding]; other site 596153004043 Mg++ binding site [ion binding]; other site 596153004044 motif III; other site 596153004045 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 596153004046 nucleotide binding region [chemical binding]; other site 596153004047 ATP-binding site [chemical binding]; other site 596153004048 PAS domain; Region: PAS_9; pfam13426 596153004049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 596153004050 PAS domain; Region: PAS_9; pfam13426 596153004051 putative active site [active] 596153004052 heme pocket [chemical binding]; other site 596153004053 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153004054 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153004055 metal binding site [ion binding]; metal-binding site 596153004056 active site 596153004057 I-site; other site 596153004058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153004059 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 596153004060 putative substrate translocation pore; other site 596153004061 Protein of unknown function (DUF461); Region: DUF461; pfam04314 596153004062 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 596153004063 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 596153004064 ligand binding site [chemical binding]; other site 596153004065 flexible hinge region; other site 596153004066 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 596153004067 putative switch regulator; other site 596153004068 non-specific DNA interactions [nucleotide binding]; other site 596153004069 DNA binding site [nucleotide binding] 596153004070 sequence specific DNA binding site [nucleotide binding]; other site 596153004071 putative cAMP binding site [chemical binding]; other site 596153004072 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 596153004073 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 596153004074 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 596153004075 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 596153004076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 596153004077 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 596153004078 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 596153004079 Walker A/P-loop; other site 596153004080 ATP binding site [chemical binding]; other site 596153004081 Q-loop/lid; other site 596153004082 ABC transporter signature motif; other site 596153004083 Walker B; other site 596153004084 D-loop; other site 596153004085 H-loop/switch region; other site 596153004086 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 596153004087 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 596153004088 N-terminal plug; other site 596153004089 ligand-binding site [chemical binding]; other site 596153004090 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 596153004091 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 596153004092 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 596153004093 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 596153004094 Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919 596153004095 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 596153004096 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 596153004097 active site 596153004098 DNA binding site [nucleotide binding] 596153004099 Int/Topo IB signature motif; other site 596153004100 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 596153004101 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 596153004102 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 596153004103 DNA binding site [nucleotide binding] 596153004104 substrate interaction site [chemical binding]; other site 596153004105 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; cl15276 596153004106 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 596153004107 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 596153004108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 596153004109 non-specific DNA binding site [nucleotide binding]; other site 596153004110 salt bridge; other site 596153004111 sequence-specific DNA binding site [nucleotide binding]; other site 596153004112 Predicted transcriptional regulator [Transcription]; Region: COG2932 596153004113 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 596153004114 Catalytic site [active] 596153004115 WYL domain; Region: WYL; pfam13280 596153004116 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 596153004117 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 596153004118 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 596153004119 tail protein; Provisional; Region: D; PHA02561 596153004120 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 596153004121 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 596153004122 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 596153004123 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 596153004124 Phage tail tube protein FII; Region: Phage_tube; pfam04985 596153004125 major tail sheath protein; Provisional; Region: FI; PHA02560 596153004126 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 596153004127 Baseplate J-like protein; Region: Baseplate_J; cl01294 596153004128 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 596153004129 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 596153004130 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 596153004131 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 596153004132 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 596153004133 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 596153004134 catalytic residue [active] 596153004135 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 596153004136 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 596153004137 terminase endonuclease subunit; Provisional; Region: M; PHA02537 596153004138 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 596153004139 capsid protein; Provisional; Region: N; PHA02538 596153004140 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 596153004141 terminase ATPase subunit; Provisional; Region: P; PHA02535 596153004142 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 596153004143 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 596153004144 Phage-related protein [Function unknown]; Region: COG4695; cl01923 596153004145 Phage portal protein; Region: Phage_portal; pfam04860 596153004146 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 596153004147 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 596153004148 active site 596153004149 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 596153004150 Part of AAA domain; Region: AAA_19; pfam13245 596153004151 AAA domain; Region: AAA_12; pfam13087 596153004152 Family description; Region: UvrD_C_2; pfam13538 596153004153 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 596153004154 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 596153004155 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 596153004156 substrate binding pocket [chemical binding]; other site 596153004157 membrane-bound complex binding site; other site 596153004158 hinge residues; other site 596153004159 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153004160 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153004161 metal binding site [ion binding]; metal-binding site 596153004162 active site 596153004163 I-site; other site 596153004164 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 596153004165 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 596153004166 putative active site [active] 596153004167 putative substrate binding site [chemical binding]; other site 596153004168 ATP binding site [chemical binding]; other site 596153004169 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 596153004170 DNA polymerase I; Provisional; Region: PRK05755 596153004171 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 596153004172 active site 596153004173 metal binding site 1 [ion binding]; metal-binding site 596153004174 putative 5' ssDNA interaction site; other site 596153004175 metal binding site 3; metal-binding site 596153004176 metal binding site 2 [ion binding]; metal-binding site 596153004177 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 596153004178 putative DNA binding site [nucleotide binding]; other site 596153004179 putative metal binding site [ion binding]; other site 596153004180 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 596153004181 active site 596153004182 catalytic site [active] 596153004183 substrate binding site [chemical binding]; other site 596153004184 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 596153004185 active site 596153004186 DNA binding site [nucleotide binding] 596153004187 catalytic site [active] 596153004188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153004189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153004190 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 596153004191 putative dimerization interface [polypeptide binding]; other site 596153004192 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 596153004193 classical (c) SDRs; Region: SDR_c; cd05233 596153004194 NAD(P) binding site [chemical binding]; other site 596153004195 active site 596153004196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153004197 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 596153004198 Uncharacterized conserved protein [Function unknown]; Region: COG2128 596153004199 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 596153004200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153004201 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 596153004202 putative dimerization interface [polypeptide binding]; other site 596153004203 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153004204 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153004205 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153004206 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 596153004207 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153004208 substrate binding site [chemical binding]; other site 596153004209 oxyanion hole (OAH) forming residues; other site 596153004210 trimer interface [polypeptide binding]; other site 596153004211 Dienelactone hydrolase family; Region: DLH; pfam01738 596153004212 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 596153004213 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 596153004214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153004215 active site 596153004216 phosphorylation site [posttranslational modification] 596153004217 intermolecular recognition site; other site 596153004218 dimerization interface [polypeptide binding]; other site 596153004219 LytTr DNA-binding domain; Region: LytTR; smart00850 596153004220 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 596153004221 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 596153004222 motif II; other site 596153004223 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 596153004224 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 596153004225 motif II; other site 596153004226 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 596153004227 Predicted membrane protein [Function unknown]; Region: COG3235 596153004228 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 596153004229 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 596153004230 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 596153004231 ATP binding site [chemical binding]; other site 596153004232 putative Mg++ binding site [ion binding]; other site 596153004233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 596153004234 nucleotide binding region [chemical binding]; other site 596153004235 ATP-binding site [chemical binding]; other site 596153004236 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 596153004237 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 596153004238 substrate binding site; other site 596153004239 dimer interface; other site 596153004240 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 596153004241 homotrimer interaction site [polypeptide binding]; other site 596153004242 zinc binding site [ion binding]; other site 596153004243 CDP-binding sites; other site 596153004244 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 596153004245 dimerization interface [polypeptide binding]; other site 596153004246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153004247 dimer interface [polypeptide binding]; other site 596153004248 phosphorylation site [posttranslational modification] 596153004249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153004250 ATP binding site [chemical binding]; other site 596153004251 Mg2+ binding site [ion binding]; other site 596153004252 G-X-G motif; other site 596153004253 osmolarity response regulator; Provisional; Region: ompR; PRK09468 596153004254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153004255 active site 596153004256 phosphorylation site [posttranslational modification] 596153004257 intermolecular recognition site; other site 596153004258 dimerization interface [polypeptide binding]; other site 596153004259 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 596153004260 DNA binding site [nucleotide binding] 596153004261 Protein of unknown function (DUF541); Region: SIMPL; cl01077 596153004262 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 596153004263 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 596153004264 NAD binding site [chemical binding]; other site 596153004265 homotetramer interface [polypeptide binding]; other site 596153004266 homodimer interface [polypeptide binding]; other site 596153004267 substrate binding site [chemical binding]; other site 596153004268 active site 596153004269 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 596153004270 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 596153004271 HD domain; Region: HD_4; pfam13328 596153004272 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 596153004273 synthetase active site [active] 596153004274 NTP binding site [chemical binding]; other site 596153004275 metal binding site [ion binding]; metal-binding site 596153004276 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 596153004277 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 596153004278 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 596153004279 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 596153004280 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 596153004281 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 596153004282 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 596153004283 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 596153004284 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 596153004285 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 596153004286 FeS/SAM binding site; other site 596153004287 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 596153004288 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 596153004289 Predicted transcriptional regulators [Transcription]; Region: COG1733 596153004290 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 596153004291 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153004292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153004293 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153004294 dimerization interface [polypeptide binding]; other site 596153004295 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 596153004296 active site 596153004297 catalytic residues [active] 596153004298 metal binding site [ion binding]; metal-binding site 596153004299 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153004300 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153004301 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153004302 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 596153004303 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 596153004304 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 596153004305 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 596153004306 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 596153004307 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 596153004308 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 596153004309 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 596153004310 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 596153004311 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 596153004312 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 596153004313 DNA binding residues [nucleotide binding] 596153004314 DNA primase, catalytic core; Region: dnaG; TIGR01391 596153004315 CHC2 zinc finger; Region: zf-CHC2; pfam01807 596153004316 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 596153004317 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 596153004318 active site 596153004319 metal binding site [ion binding]; metal-binding site 596153004320 interdomain interaction site; other site 596153004321 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 596153004322 acyl-CoA synthetase; Validated; Region: PRK08162 596153004323 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 596153004324 acyl-activating enzyme (AAE) consensus motif; other site 596153004325 putative active site [active] 596153004326 AMP binding site [chemical binding]; other site 596153004327 putative CoA binding site [chemical binding]; other site 596153004328 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 596153004329 putative active site [active] 596153004330 catalytic site [active] 596153004331 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 596153004332 PLD-like domain; Region: PLDc_2; pfam13091 596153004333 putative active site [active] 596153004334 catalytic site [active] 596153004335 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 596153004336 PBP superfamily domain; Region: PBP_like; pfam12727 596153004337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 596153004338 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 596153004339 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 596153004340 Walker A/P-loop; other site 596153004341 ATP binding site [chemical binding]; other site 596153004342 Q-loop/lid; other site 596153004343 ABC transporter signature motif; other site 596153004344 Walker B; other site 596153004345 D-loop; other site 596153004346 H-loop/switch region; other site 596153004347 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 596153004348 PBP superfamily domain; Region: PBP_like_2; pfam12849 596153004349 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 596153004350 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 596153004351 Walker A/P-loop; other site 596153004352 ATP binding site [chemical binding]; other site 596153004353 Q-loop/lid; other site 596153004354 ABC transporter signature motif; other site 596153004355 Walker B; other site 596153004356 D-loop; other site 596153004357 H-loop/switch region; other site 596153004358 TOBE domain; Region: TOBE; pfam03459 596153004359 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 596153004360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153004361 putative PBP binding loops; other site 596153004362 dimer interface [polypeptide binding]; other site 596153004363 ABC-ATPase subunit interface; other site 596153004364 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 596153004365 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 596153004366 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 596153004367 TOBE domain; Region: TOBE; cl01440 596153004368 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 596153004369 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 596153004370 Walker A/P-loop; other site 596153004371 ATP binding site [chemical binding]; other site 596153004372 Q-loop/lid; other site 596153004373 ABC transporter signature motif; other site 596153004374 Walker B; other site 596153004375 D-loop; other site 596153004376 H-loop/switch region; other site 596153004377 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 596153004378 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 596153004379 Walker A/P-loop; other site 596153004380 ATP binding site [chemical binding]; other site 596153004381 Q-loop/lid; other site 596153004382 ABC transporter signature motif; other site 596153004383 Walker B; other site 596153004384 D-loop; other site 596153004385 H-loop/switch region; other site 596153004386 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153004387 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 596153004388 putative ligand binding site [chemical binding]; other site 596153004389 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153004390 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 596153004391 putative ligand binding site [chemical binding]; other site 596153004392 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 596153004393 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 596153004394 TM-ABC transporter signature motif; other site 596153004395 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 596153004396 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 596153004397 TM-ABC transporter signature motif; other site 596153004398 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 596153004399 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 596153004400 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 596153004401 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 596153004402 catalytic residue [active] 596153004403 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 596153004404 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 596153004405 FtsX-like permease family; Region: FtsX; pfam02687 596153004406 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 596153004407 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 596153004408 putative dimer interface [polypeptide binding]; other site 596153004409 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 596153004410 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 596153004411 Walker A/P-loop; other site 596153004412 ATP binding site [chemical binding]; other site 596153004413 Q-loop/lid; other site 596153004414 ABC transporter signature motif; other site 596153004415 Walker B; other site 596153004416 D-loop; other site 596153004417 H-loop/switch region; other site 596153004418 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 596153004419 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 596153004420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153004421 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 596153004422 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 596153004423 putative ligand binding site [chemical binding]; other site 596153004424 NAD binding site [chemical binding]; other site 596153004425 catalytic site [active] 596153004426 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 596153004427 HIT family signature motif; other site 596153004428 catalytic residue [active] 596153004429 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 596153004430 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 596153004431 trimer interface [polypeptide binding]; other site 596153004432 eyelet of channel; other site 596153004433 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 596153004434 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 596153004435 ligand binding site [chemical binding]; other site 596153004436 flexible hinge region; other site 596153004437 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 596153004438 putative switch regulator; other site 596153004439 non-specific DNA interactions [nucleotide binding]; other site 596153004440 DNA binding site [nucleotide binding] 596153004441 sequence specific DNA binding site [nucleotide binding]; other site 596153004442 putative cAMP binding site [chemical binding]; other site 596153004443 PAS domain; Region: PAS_9; pfam13426 596153004444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153004445 putative active site [active] 596153004446 heme pocket [chemical binding]; other site 596153004447 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153004448 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153004449 metal binding site [ion binding]; metal-binding site 596153004450 active site 596153004451 I-site; other site 596153004452 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 596153004453 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 596153004454 Walker A/P-loop; other site 596153004455 ATP binding site [chemical binding]; other site 596153004456 Q-loop/lid; other site 596153004457 ABC transporter signature motif; other site 596153004458 Walker B; other site 596153004459 D-loop; other site 596153004460 H-loop/switch region; other site 596153004461 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 596153004462 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 596153004463 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 596153004464 TM-ABC transporter signature motif; other site 596153004465 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 596153004466 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 596153004467 TM-ABC transporter signature motif; other site 596153004468 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 596153004469 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 596153004470 putative ligand binding site [chemical binding]; other site 596153004471 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 596153004472 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 596153004473 putative ligand binding site [chemical binding]; other site 596153004474 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 596153004475 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 596153004476 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 596153004477 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 596153004478 Walker A/P-loop; other site 596153004479 ATP binding site [chemical binding]; other site 596153004480 Q-loop/lid; other site 596153004481 ABC transporter signature motif; other site 596153004482 Walker B; other site 596153004483 D-loop; other site 596153004484 H-loop/switch region; other site 596153004485 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 596153004486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153004487 dimer interface [polypeptide binding]; other site 596153004488 conserved gate region; other site 596153004489 putative PBP binding loops; other site 596153004490 ABC-ATPase subunit interface; other site 596153004491 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 596153004492 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 596153004493 substrate binding pocket [chemical binding]; other site 596153004494 membrane-bound complex binding site; other site 596153004495 hinge residues; other site 596153004496 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 596153004497 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153004498 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153004499 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 596153004500 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 596153004501 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 596153004502 active site 596153004503 purine riboside binding site [chemical binding]; other site 596153004504 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 596153004505 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 596153004506 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 596153004507 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 596153004508 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 596153004509 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 596153004510 Walker A/P-loop; other site 596153004511 ATP binding site [chemical binding]; other site 596153004512 Q-loop/lid; other site 596153004513 ABC transporter signature motif; other site 596153004514 Walker B; other site 596153004515 D-loop; other site 596153004516 H-loop/switch region; other site 596153004517 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 596153004518 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 596153004519 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 596153004520 Walker A/P-loop; other site 596153004521 ATP binding site [chemical binding]; other site 596153004522 Q-loop/lid; other site 596153004523 ABC transporter signature motif; other site 596153004524 Walker B; other site 596153004525 D-loop; other site 596153004526 H-loop/switch region; other site 596153004527 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 596153004528 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 596153004529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153004530 dimer interface [polypeptide binding]; other site 596153004531 conserved gate region; other site 596153004532 putative PBP binding loops; other site 596153004533 ABC-ATPase subunit interface; other site 596153004534 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 596153004535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153004536 dimer interface [polypeptide binding]; other site 596153004537 conserved gate region; other site 596153004538 putative PBP binding loops; other site 596153004539 ABC-ATPase subunit interface; other site 596153004540 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153004541 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153004542 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153004543 dimerization interface [polypeptide binding]; other site 596153004544 Putative cyclase; Region: Cyclase; cl00814 596153004545 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 596153004546 FeoA domain; Region: FeoA; pfam04023 596153004547 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 596153004548 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 596153004549 G1 box; other site 596153004550 GTP/Mg2+ binding site [chemical binding]; other site 596153004551 Switch I region; other site 596153004552 G2 box; other site 596153004553 G3 box; other site 596153004554 Switch II region; other site 596153004555 G4 box; other site 596153004556 G5 box; other site 596153004557 Nucleoside recognition; Region: Gate; pfam07670 596153004558 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 596153004559 Nucleoside recognition; Region: Gate; pfam07670 596153004560 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 596153004561 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 596153004562 Protein of unknown function, DUF488; Region: DUF488; pfam04343 596153004563 ornithine carbamoyltransferase; Provisional; Region: PRK00779 596153004564 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 596153004565 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 596153004566 acetylornithine aminotransferase; Provisional; Region: PRK02627 596153004567 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 596153004568 inhibitor-cofactor binding pocket; inhibition site 596153004569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153004570 catalytic residue [active] 596153004571 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 596153004572 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 596153004573 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 596153004574 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 596153004575 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 596153004576 Uncharacterized conserved protein [Function unknown]; Region: COG2912 596153004577 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 596153004578 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 596153004579 Ligand Binding Site [chemical binding]; other site 596153004580 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 596153004581 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 596153004582 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 596153004583 dimerization interface [polypeptide binding]; other site 596153004584 putative ATP binding site [chemical binding]; other site 596153004585 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 596153004586 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 596153004587 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 596153004588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 596153004589 Walker A motif; other site 596153004590 ATP binding site [chemical binding]; other site 596153004591 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 596153004592 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 596153004593 poly(A) polymerase; Region: pcnB; TIGR01942 596153004594 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 596153004595 active site 596153004596 NTP binding site [chemical binding]; other site 596153004597 metal binding triad [ion binding]; metal-binding site 596153004598 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 596153004599 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 596153004600 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 596153004601 catalytic center binding site [active] 596153004602 ATP binding site [chemical binding]; other site 596153004603 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 596153004604 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 596153004605 Ligand binding site; other site 596153004606 Putative Catalytic site; other site 596153004607 DXD motif; other site 596153004608 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 596153004609 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 596153004610 Predicted membrane protein [Function unknown]; Region: COG2246 596153004611 GtrA-like protein; Region: GtrA; pfam04138 596153004612 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 596153004613 putative active site [active] 596153004614 YdjC motif; other site 596153004615 Mg binding site [ion binding]; other site 596153004616 putative homodimer interface [polypeptide binding]; other site 596153004617 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153004618 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153004619 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 596153004620 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153004621 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153004622 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 596153004623 putative dimerization interface [polypeptide binding]; other site 596153004624 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 596153004625 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 596153004626 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 596153004627 catalytic residue [active] 596153004628 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 596153004629 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 596153004630 catalytic loop [active] 596153004631 iron binding site [ion binding]; other site 596153004632 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 596153004633 FAD binding pocket [chemical binding]; other site 596153004634 FAD binding motif [chemical binding]; other site 596153004635 phosphate binding motif [ion binding]; other site 596153004636 beta-alpha-beta structure motif; other site 596153004637 NAD binding pocket [chemical binding]; other site 596153004638 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 596153004639 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 596153004640 putative NAD(P) binding site [chemical binding]; other site 596153004641 Transposase domain (DUF772); Region: DUF772; pfam05598 596153004642 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 596153004643 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 596153004644 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153004645 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153004646 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153004647 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 596153004648 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153004649 FAD binding site [chemical binding]; other site 596153004650 substrate binding pocket [chemical binding]; other site 596153004651 catalytic base [active] 596153004652 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 596153004653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153004654 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153004655 dimerization interface [polypeptide binding]; other site 596153004656 LrgB-like family; Region: LrgB; cl00596 596153004657 LrgA family; Region: LrgA; pfam03788 596153004658 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 596153004659 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 596153004660 oligomerization interface [polypeptide binding]; other site 596153004661 Phage Terminase; Region: Terminase_1; pfam03354 596153004662 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 596153004663 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 596153004664 active site 596153004665 Phage-related protein [Function unknown]; Region: COG4695 596153004666 Phage portal protein; Region: Phage_portal; pfam04860 596153004667 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 596153004668 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 596153004669 Phage capsid family; Region: Phage_capsid; pfam05065 596153004670 Helix-turn-helix domain; Region: HTH_36; pfam13730 596153004671 Transposase; Region: HTH_Tnp_1; cl17663 596153004672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153004673 putative transposase OrfB; Reviewed; Region: PHA02517 596153004674 HTH-like domain; Region: HTH_21; pfam13276 596153004675 Integrase core domain; Region: rve; pfam00665 596153004676 Integrase core domain; Region: rve_3; cl15866 596153004677 Helix-turn-helix domain; Region: HTH_39; pfam14090 596153004678 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 596153004679 integrase; Provisional; Region: PRK09692 596153004680 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 596153004681 active site 596153004682 Int/Topo IB signature motif; other site 596153004683 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 596153004684 active site 596153004685 Zn binding site [ion binding]; other site 596153004686 helicase 45; Provisional; Region: PTZ00424 596153004687 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 596153004688 ATP binding site [chemical binding]; other site 596153004689 Mg++ binding site [ion binding]; other site 596153004690 motif III; other site 596153004691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 596153004692 nucleotide binding region [chemical binding]; other site 596153004693 ATP-binding site [chemical binding]; other site 596153004694 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 596153004695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 596153004696 Walker A/P-loop; other site 596153004697 ATP binding site [chemical binding]; other site 596153004698 Q-loop/lid; other site 596153004699 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 596153004700 ABC transporter; Region: ABC_tran_2; pfam12848 596153004701 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 596153004702 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 596153004703 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 596153004704 putative active site pocket [active] 596153004705 cleavage site 596153004706 Predicted metal-binding protein [General function prediction only]; Region: COG3019 596153004707 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 596153004708 Uncharacterized conserved protein [Function unknown]; Region: COG1284 596153004709 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 596153004710 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 596153004711 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 596153004712 Soluble P-type ATPase [General function prediction only]; Region: COG4087 596153004713 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 596153004714 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 596153004715 DNA binding residues [nucleotide binding] 596153004716 dimer interface [polypeptide binding]; other site 596153004717 putative metal binding site [ion binding]; other site 596153004718 Permease; Region: Permease; pfam02405 596153004719 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 596153004720 mce related protein; Region: MCE; pfam02470 596153004721 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 596153004722 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 596153004723 tetramer interface [polypeptide binding]; other site 596153004724 active site 596153004725 Mg2+/Mn2+ binding site [ion binding]; other site 596153004726 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 596153004727 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 596153004728 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 596153004729 hydroxyglutarate oxidase; Provisional; Region: PRK11728 596153004730 amidase; Provisional; Region: PRK07056 596153004731 Amidase; Region: Amidase; cl11426 596153004732 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 596153004733 rRNA interaction site [nucleotide binding]; other site 596153004734 S8 interaction site; other site 596153004735 putative laminin-1 binding site; other site 596153004736 elongation factor Ts; Provisional; Region: tsf; PRK09377 596153004737 UBA/TS-N domain; Region: UBA; pfam00627 596153004738 Elongation factor TS; Region: EF_TS; pfam00889 596153004739 Elongation factor TS; Region: EF_TS; pfam00889 596153004740 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 596153004741 putative nucleotide binding site [chemical binding]; other site 596153004742 uridine monophosphate binding site [chemical binding]; other site 596153004743 homohexameric interface [polypeptide binding]; other site 596153004744 ribosome recycling factor; Reviewed; Region: frr; PRK00083 596153004745 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 596153004746 hinge region; other site 596153004747 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 596153004748 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 596153004749 catalytic residue [active] 596153004750 putative FPP diphosphate binding site; other site 596153004751 putative FPP binding hydrophobic cleft; other site 596153004752 dimer interface [polypeptide binding]; other site 596153004753 putative IPP diphosphate binding site; other site 596153004754 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 596153004755 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 596153004756 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 596153004757 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 596153004758 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 596153004759 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 596153004760 zinc metallopeptidase RseP; Provisional; Region: PRK10779 596153004761 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 596153004762 active site 596153004763 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 596153004764 protein binding site [polypeptide binding]; other site 596153004765 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 596153004766 putative substrate binding region [chemical binding]; other site 596153004767 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 596153004768 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 596153004769 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 596153004770 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 596153004771 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 596153004772 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 596153004773 Surface antigen; Region: Bac_surface_Ag; pfam01103 596153004774 periplasmic chaperone; Provisional; Region: PRK10780 596153004775 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 596153004776 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 596153004777 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 596153004778 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 596153004779 trimer interface [polypeptide binding]; other site 596153004780 active site 596153004781 UDP-GlcNAc binding site [chemical binding]; other site 596153004782 lipid binding site [chemical binding]; lipid-binding site 596153004783 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 596153004784 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 596153004785 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 596153004786 active site 596153004787 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 596153004788 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 596153004789 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 596153004790 RNA/DNA hybrid binding site [nucleotide binding]; other site 596153004791 active site 596153004792 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 596153004793 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 596153004794 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 596153004795 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 596153004796 active site 596153004797 DNA binding site [nucleotide binding] 596153004798 Int/Topo IB signature motif; other site 596153004799 Transposase; Region: HTH_Tnp_1; cl17663 596153004800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153004801 putative transposase OrfB; Reviewed; Region: PHA02517 596153004802 HTH-like domain; Region: HTH_21; pfam13276 596153004803 Integrase core domain; Region: rve; pfam00665 596153004804 Integrase core domain; Region: rve_3; cl15866 596153004805 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 596153004806 AMP binding site [chemical binding]; other site 596153004807 metal binding site [ion binding]; metal-binding site 596153004808 active site 596153004809 aminopeptidase N; Provisional; Region: pepN; PRK14015 596153004810 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 596153004811 active site 596153004812 Zn binding site [ion binding]; other site 596153004813 peptide chain release factor 2; Validated; Region: prfB; PRK00578 596153004814 This domain is found in peptide chain release factors; Region: PCRF; smart00937 596153004815 RF-1 domain; Region: RF-1; pfam00472 596153004816 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 596153004817 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 596153004818 NAD binding site [chemical binding]; other site 596153004819 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 596153004820 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 596153004821 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 596153004822 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 596153004823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153004824 dimer interface [polypeptide binding]; other site 596153004825 conserved gate region; other site 596153004826 putative PBP binding loops; other site 596153004827 ABC-ATPase subunit interface; other site 596153004828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153004829 dimer interface [polypeptide binding]; other site 596153004830 conserved gate region; other site 596153004831 putative PBP binding loops; other site 596153004832 ABC-ATPase subunit interface; other site 596153004833 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 596153004834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 596153004835 Walker A/P-loop; other site 596153004836 ATP binding site [chemical binding]; other site 596153004837 Q-loop/lid; other site 596153004838 ABC transporter signature motif; other site 596153004839 Walker B; other site 596153004840 D-loop; other site 596153004841 H-loop/switch region; other site 596153004842 TOBE domain; Region: TOBE_2; pfam08402 596153004843 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 596153004844 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 596153004845 active site 596153004846 catalytic tetrad [active] 596153004847 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 596153004848 putative deacylase active site [active] 596153004849 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 596153004850 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 596153004851 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 596153004852 catalytic motif [active] 596153004853 Catalytic residue [active] 596153004854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 596153004855 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 596153004856 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 596153004857 FAD binding domain; Region: FAD_binding_4; pfam01565 596153004858 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 596153004859 SPW repeat; Region: SPW; pfam03779 596153004860 SPW repeat; Region: SPW; pfam03779 596153004861 hypothetical protein; Provisional; Region: PRK11212 596153004862 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 596153004863 Ligand Binding Site [chemical binding]; other site 596153004864 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 596153004865 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 596153004866 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 596153004867 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 596153004868 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 596153004869 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 596153004870 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 596153004871 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 596153004872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153004873 Walker A motif; other site 596153004874 ATP binding site [chemical binding]; other site 596153004875 Walker B motif; other site 596153004876 arginine finger; other site 596153004877 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 596153004878 argininosuccinate synthase; Validated; Region: PRK05370 596153004879 argininosuccinate synthase; Provisional; Region: PRK13820 596153004880 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 596153004881 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 596153004882 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 596153004883 ArsC family; Region: ArsC; pfam03960 596153004884 putative catalytic residues [active] 596153004885 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 596153004886 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 596153004887 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 596153004888 Sporulation related domain; Region: SPOR; pfam05036 596153004889 Colicin V production protein; Region: Colicin_V; pfam02674 596153004890 amidophosphoribosyltransferase; Provisional; Region: PRK09246 596153004891 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 596153004892 active site 596153004893 tetramer interface [polypeptide binding]; other site 596153004894 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 596153004895 active site 596153004896 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 596153004897 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 596153004898 homodimer interface [polypeptide binding]; other site 596153004899 substrate-cofactor binding pocket; other site 596153004900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153004901 catalytic residue [active] 596153004902 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 596153004903 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 596153004904 active site 596153004905 HIGH motif; other site 596153004906 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 596153004907 active site 596153004908 KMSKS motif; other site 596153004909 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 596153004910 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 596153004911 NAD binding site [chemical binding]; other site 596153004912 homodimer interface [polypeptide binding]; other site 596153004913 homotetramer interface [polypeptide binding]; other site 596153004914 active site 596153004915 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 596153004916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 596153004917 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 596153004918 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 596153004919 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 596153004920 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 596153004921 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 596153004922 Transposase; Region: HTH_Tnp_1; pfam01527 596153004923 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153004924 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 596153004925 putative transposase OrfB; Reviewed; Region: PHA02517 596153004926 Integrase core domain; Region: rve; pfam00665 596153004927 Integrase core domain; Region: rve_3; pfam13683 596153004928 Transposase; Region: HTH_Tnp_1; pfam01527 596153004929 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 596153004930 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 596153004931 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 596153004932 LexA repressor; Validated; Region: PRK00215 596153004933 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 596153004934 Catalytic site [active] 596153004935 Transposase; Region: HTH_Tnp_1; cl17663 596153004936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153004937 putative transposase OrfB; Reviewed; Region: PHA02517 596153004938 HTH-like domain; Region: HTH_21; pfam13276 596153004939 Integrase core domain; Region: rve; pfam00665 596153004940 Integrase core domain; Region: rve_3; cl15866 596153004941 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 596153004942 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 596153004943 Phasin protein; Region: Phasin_2; pfam09361 596153004944 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 596153004945 active site 596153004946 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 596153004947 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 596153004948 active site 596153004949 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 596153004950 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 596153004951 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 596153004952 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 596153004953 dimerization interface [polypeptide binding]; other site 596153004954 ligand binding site [chemical binding]; other site 596153004955 NADP binding site [chemical binding]; other site 596153004956 catalytic site [active] 596153004957 RmuC family; Region: RmuC; pfam02646 596153004958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153004959 putative substrate translocation pore; other site 596153004960 Major Facilitator Superfamily; Region: MFS_1; pfam07690 596153004961 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 596153004962 chromosome condensation membrane protein; Provisional; Region: PRK14196 596153004963 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_5; cd06232 596153004964 putative active site [active] 596153004965 Zn binding site [ion binding]; other site 596153004966 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 596153004967 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 596153004968 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 596153004969 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 596153004970 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 596153004971 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 596153004972 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 596153004973 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 596153004974 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 596153004975 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 596153004976 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 596153004977 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 596153004978 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 596153004979 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 596153004980 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 596153004981 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 596153004982 intracellular septation protein A; Reviewed; Region: PRK00259 596153004983 methionine sulfoxide reductase B; Provisional; Region: PRK00222 596153004984 SelR domain; Region: SelR; pfam01641 596153004985 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153004986 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 596153004987 putative ligand binding site [chemical binding]; other site 596153004988 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 596153004989 TM-ABC transporter signature motif; other site 596153004990 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 596153004991 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 596153004992 TM-ABC transporter signature motif; other site 596153004993 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 596153004994 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 596153004995 Walker A/P-loop; other site 596153004996 ATP binding site [chemical binding]; other site 596153004997 Q-loop/lid; other site 596153004998 ABC transporter signature motif; other site 596153004999 Walker B; other site 596153005000 D-loop; other site 596153005001 H-loop/switch region; other site 596153005002 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 596153005003 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 596153005004 Walker A/P-loop; other site 596153005005 ATP binding site [chemical binding]; other site 596153005006 Q-loop/lid; other site 596153005007 ABC transporter signature motif; other site 596153005008 Walker B; other site 596153005009 D-loop; other site 596153005010 H-loop/switch region; other site 596153005011 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153005012 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 596153005013 substrate binding site [chemical binding]; other site 596153005014 oxyanion hole (OAH) forming residues; other site 596153005015 trimer interface [polypeptide binding]; other site 596153005016 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 596153005017 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 596153005018 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 596153005019 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 596153005020 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 596153005021 dimer interface [polypeptide binding]; other site 596153005022 active site 596153005023 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 596153005024 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 596153005025 substrate binding pocket [chemical binding]; other site 596153005026 membrane-bound complex binding site; other site 596153005027 hinge residues; other site 596153005028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153005029 dimer interface [polypeptide binding]; other site 596153005030 conserved gate region; other site 596153005031 putative PBP binding loops; other site 596153005032 ABC-ATPase subunit interface; other site 596153005033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153005034 dimer interface [polypeptide binding]; other site 596153005035 conserved gate region; other site 596153005036 putative PBP binding loops; other site 596153005037 ABC-ATPase subunit interface; other site 596153005038 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 596153005039 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153005040 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153005041 active site 596153005042 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 596153005043 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 596153005044 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 596153005045 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 596153005046 EamA-like transporter family; Region: EamA; pfam00892 596153005047 VRR-NUC domain; Region: VRR_NUC; pfam08774 596153005048 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 596153005049 AAA domain; Region: AAA_25; pfam13481 596153005050 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 596153005051 Walker A motif; other site 596153005052 ATP binding site [chemical binding]; other site 596153005053 Walker B motif; other site 596153005054 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 596153005055 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 596153005056 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 596153005057 active site 596153005058 catalytic residues [active] 596153005059 DNA binding site [nucleotide binding] 596153005060 Int/Topo IB signature motif; other site 596153005061 Outer membrane efflux protein; Region: OEP; pfam02321 596153005062 Outer membrane efflux protein; Region: OEP; pfam02321 596153005063 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 596153005064 active site residue [active] 596153005065 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 596153005066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153005067 S-adenosylmethionine binding site [chemical binding]; other site 596153005068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 596153005069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 596153005070 methionine sulfoxide reductase A; Provisional; Region: PRK14054 596153005071 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 596153005072 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 596153005073 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 596153005074 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 596153005075 Chromate transporter; Region: Chromate_transp; pfam02417 596153005076 Membrane transport protein; Region: Mem_trans; cl09117 596153005077 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 596153005078 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 596153005079 putative active site pocket [active] 596153005080 dimerization interface [polypeptide binding]; other site 596153005081 putative catalytic residue [active] 596153005082 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 596153005083 ligand binding site [chemical binding]; other site 596153005084 Protein of unknown function DUF72; Region: DUF72; pfam01904 596153005085 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 596153005086 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 596153005087 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 596153005088 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 596153005089 RNA binding site [nucleotide binding]; other site 596153005090 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153005091 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 596153005092 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 596153005093 DUF35 OB-fold domain; Region: DUF35; pfam01796 596153005094 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 596153005095 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 596153005096 active site 596153005097 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153005098 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 596153005099 classical (c) SDRs; Region: SDR_c; cd05233 596153005100 NAD(P) binding site [chemical binding]; other site 596153005101 active site 596153005102 acyl-CoA synthetase; Validated; Region: PRK06188 596153005103 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153005104 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 596153005105 acyl-activating enzyme (AAE) consensus motif; other site 596153005106 acyl-activating enzyme (AAE) consensus motif; other site 596153005107 putative AMP binding site [chemical binding]; other site 596153005108 putative active site [active] 596153005109 putative CoA binding site [chemical binding]; other site 596153005110 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153005111 Transcriptional regulators [Transcription]; Region: PurR; COG1609 596153005112 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 596153005113 DNA binding site [nucleotide binding] 596153005114 domain linker motif; other site 596153005115 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_5; cd06281 596153005116 putative dimerization interface [polypeptide binding]; other site 596153005117 putative ligand binding site [chemical binding]; other site 596153005118 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 596153005119 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 596153005120 active site 596153005121 oxalacetate binding site [chemical binding]; other site 596153005122 citrylCoA binding site [chemical binding]; other site 596153005123 coenzyme A binding site [chemical binding]; other site 596153005124 catalytic triad [active] 596153005125 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153005126 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153005127 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153005128 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153005129 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 596153005130 Amidohydrolase; Region: Amidohydro_2; pfam04909 596153005131 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153005132 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 596153005133 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153005134 HDOD domain; Region: HDOD; pfam08668 596153005135 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 596153005136 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 596153005137 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 596153005138 active site 596153005139 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 596153005140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 596153005141 Coenzyme A binding pocket [chemical binding]; other site 596153005142 Domain of unknown function (DUF336); Region: DUF336; cl01249 596153005143 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 596153005144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153005145 active site 596153005146 phosphorylation site [posttranslational modification] 596153005147 intermolecular recognition site; other site 596153005148 dimerization interface [polypeptide binding]; other site 596153005149 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 596153005150 DNA binding residues [nucleotide binding] 596153005151 dimerization interface [polypeptide binding]; other site 596153005152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153005153 ATP binding site [chemical binding]; other site 596153005154 Mg2+ binding site [ion binding]; other site 596153005155 G-X-G motif; other site 596153005156 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 596153005157 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 596153005158 nucleoside/Zn binding site; other site 596153005159 dimer interface [polypeptide binding]; other site 596153005160 catalytic motif [active] 596153005161 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 596153005162 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 596153005163 YceG-like family; Region: YceG; pfam02618 596153005164 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 596153005165 dimerization interface [polypeptide binding]; other site 596153005166 thymidylate kinase; Validated; Region: tmk; PRK00698 596153005167 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 596153005168 TMP-binding site; other site 596153005169 ATP-binding site [chemical binding]; other site 596153005170 DNA polymerase III subunit delta'; Validated; Region: PRK06964 596153005171 DNA polymerase III subunit delta'; Validated; Region: PRK08485 596153005172 PilZ domain; Region: PilZ; cl01260 596153005173 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 596153005174 active site 596153005175 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 596153005176 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 596153005177 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 596153005178 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 596153005179 Transcriptional regulators [Transcription]; Region: GntR; COG1802 596153005180 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153005181 DNA-binding site [nucleotide binding]; DNA binding site 596153005182 FCD domain; Region: FCD; pfam07729 596153005183 benzoate transport; Region: 2A0115; TIGR00895 596153005184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153005185 putative substrate translocation pore; other site 596153005186 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 596153005187 putative active site [active] 596153005188 hypothetical protein; Provisional; Region: PRK05463 596153005189 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 596153005190 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 596153005191 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 596153005192 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 596153005193 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 596153005194 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 596153005195 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 596153005196 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 596153005197 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 596153005198 carboxyltransferase (CT) interaction site; other site 596153005199 biotinylation site [posttranslational modification]; other site 596153005200 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 596153005201 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 596153005202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 596153005203 Walker A/P-loop; other site 596153005204 ATP binding site [chemical binding]; other site 596153005205 Q-loop/lid; other site 596153005206 ABC transporter signature motif; other site 596153005207 Walker B; other site 596153005208 D-loop; other site 596153005209 H-loop/switch region; other site 596153005210 translocation protein TolB; Provisional; Region: tolB; PRK02889 596153005211 TolB amino-terminal domain; Region: TolB_N; pfam04052 596153005212 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 596153005213 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 596153005214 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 596153005215 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 596153005216 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 596153005217 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 596153005218 ligand binding site [chemical binding]; other site 596153005219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 596153005220 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 596153005221 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 596153005222 putative ATP binding site [chemical binding]; other site 596153005223 putative substrate interface [chemical binding]; other site 596153005224 integrase; Provisional; Region: int; PHA02601 596153005225 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 596153005226 active site 596153005227 catalytic residues [active] 596153005228 DNA binding site [nucleotide binding] 596153005229 Int/Topo IB signature motif; other site 596153005230 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 596153005231 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 596153005232 ERF superfamily; Region: ERF; pfam04404 596153005233 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06069 596153005234 AAA ATPase domain; Region: AAA_16; pfam13191 596153005235 AAA domain; Region: AAA_22; pfam13401 596153005236 Staphylococcal nuclease homologues; Region: SNc; smart00318 596153005237 Catalytic site; other site 596153005238 Staphylococcal nuclease homologue; Region: SNase; pfam00565 596153005239 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 596153005240 Catalytic site [active] 596153005241 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 596153005242 non-specific DNA binding site [nucleotide binding]; other site 596153005243 salt bridge; other site 596153005244 sequence-specific DNA binding site [nucleotide binding]; other site 596153005245 replicative DNA helicase; Region: DnaB; TIGR00665 596153005246 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 596153005247 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 596153005248 Walker A motif; other site 596153005249 ATP binding site [chemical binding]; other site 596153005250 Walker B motif; other site 596153005251 DNA binding loops [nucleotide binding] 596153005252 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 596153005253 Protein of unknown function (DUF968); Region: DUF968; pfam06147 596153005254 large terminase protein; Provisional; Region: 17; PHA02533 596153005255 Terminase-like family; Region: Terminase_6; pfam03237 596153005256 Protein of unknown function (DUF4043); Region: DUF4043; pfam13252 596153005257 DNA protecting protein DprA; Region: dprA; TIGR00732 596153005258 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 596153005259 electron transport complex protein RnfC; Provisional; Region: PRK05035 596153005260 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 596153005261 catalytic residue [active] 596153005262 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 596153005263 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 596153005264 YcfA-like protein; Region: YcfA; pfam07927 596153005265 Transposase domain (DUF772); Region: DUF772; pfam05598 596153005266 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 596153005267 DDE superfamily endonuclease; Region: DDE_4; cl17710 596153005268 Predicted periplasmic protein [Function unknown]; Region: COG3904 596153005269 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 596153005270 transposase/IS protein; Provisional; Region: PRK09183 596153005271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153005272 Walker A motif; other site 596153005273 ATP binding site [chemical binding]; other site 596153005274 Walker B motif; other site 596153005275 arginine finger; other site 596153005276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 596153005277 Integrase core domain; Region: rve; pfam00665 596153005278 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 596153005279 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 596153005280 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 596153005281 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 596153005282 active site 596153005283 DNA binding site [nucleotide binding] 596153005284 Int/Topo IB signature motif; other site 596153005285 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 596153005286 NMT1/THI5 like; Region: NMT1; pfam09084 596153005287 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 596153005288 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 596153005289 N-acetyl-D-glucosamine binding site [chemical binding]; other site 596153005290 catalytic residue [active] 596153005291 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 596153005292 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 596153005293 Methyltransferase domain; Region: Methyltransf_11; pfam08241 596153005294 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 596153005295 RNA/DNA hybrid binding site [nucleotide binding]; other site 596153005296 active site 596153005297 aspartate aminotransferase; Provisional; Region: PRK05764 596153005298 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 596153005299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153005300 homodimer interface [polypeptide binding]; other site 596153005301 catalytic residue [active] 596153005302 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 596153005303 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 596153005304 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 596153005305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153005306 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 596153005307 dimerization interface [polypeptide binding]; other site 596153005308 substrate binding pocket [chemical binding]; other site 596153005309 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 596153005310 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 596153005311 substrate binding pocket [chemical binding]; other site 596153005312 membrane-bound complex binding site; other site 596153005313 hinge residues; other site 596153005314 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 596153005315 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153005316 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 596153005317 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 596153005318 catalytic residues [active] 596153005319 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 596153005320 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 596153005321 dimer interface [polypeptide binding]; other site 596153005322 putative functional site; other site 596153005323 putative MPT binding site; other site 596153005324 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 596153005325 Coenzyme A binding pocket [chemical binding]; other site 596153005326 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 596153005327 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 596153005328 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 596153005329 GTP binding site; other site 596153005330 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 596153005331 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 596153005332 FeS/SAM binding site; other site 596153005333 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 596153005334 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 596153005335 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 596153005336 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 596153005337 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 596153005338 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 596153005339 NAD(P) binding site [chemical binding]; other site 596153005340 catalytic residues [active] 596153005341 catalytic residues [active] 596153005342 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 596153005343 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 596153005344 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 596153005345 dimer interface [polypeptide binding]; other site 596153005346 substrate binding site [chemical binding]; other site 596153005347 metal binding sites [ion binding]; metal-binding site 596153005348 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 596153005349 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 596153005350 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 596153005351 dimerization interface [polypeptide binding]; other site 596153005352 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 596153005353 dimer interface [polypeptide binding]; other site 596153005354 putative CheW interface [polypeptide binding]; other site 596153005355 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 596153005356 Protein of unknown function, DUF482; Region: DUF482; pfam04339 596153005357 NAD synthetase; Provisional; Region: PRK13981 596153005358 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 596153005359 multimer interface [polypeptide binding]; other site 596153005360 active site 596153005361 catalytic triad [active] 596153005362 protein interface 1 [polypeptide binding]; other site 596153005363 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 596153005364 homodimer interface [polypeptide binding]; other site 596153005365 NAD binding pocket [chemical binding]; other site 596153005366 ATP binding pocket [chemical binding]; other site 596153005367 Mg binding site [ion binding]; other site 596153005368 active-site loop [active] 596153005369 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 596153005370 Nitrogen regulatory protein P-II; Region: P-II; smart00938 596153005371 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 596153005372 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 596153005373 RDD family; Region: RDD; pfam06271 596153005374 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 596153005375 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 596153005376 RNA polymerase factor sigma-70; Validated; Region: PRK09047 596153005377 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 596153005378 DNA binding residues [nucleotide binding] 596153005379 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 596153005380 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 596153005381 PYR/PP interface [polypeptide binding]; other site 596153005382 dimer interface [polypeptide binding]; other site 596153005383 TPP binding site [chemical binding]; other site 596153005384 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 596153005385 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 596153005386 TPP-binding site [chemical binding]; other site 596153005387 dimer interface [polypeptide binding]; other site 596153005388 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 596153005389 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 596153005390 putative valine binding site [chemical binding]; other site 596153005391 dimer interface [polypeptide binding]; other site 596153005392 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 596153005393 ketol-acid reductoisomerase; Provisional; Region: PRK05479 596153005394 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 596153005395 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 596153005396 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 596153005397 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 596153005398 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 596153005399 maleylacetoacetate isomerase; Region: maiA; TIGR01262 596153005400 C-terminal domain interface [polypeptide binding]; other site 596153005401 GSH binding site (G-site) [chemical binding]; other site 596153005402 putative dimer interface [polypeptide binding]; other site 596153005403 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 596153005404 dimer interface [polypeptide binding]; other site 596153005405 N-terminal domain interface [polypeptide binding]; other site 596153005406 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 596153005407 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 596153005408 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 596153005409 benzoate transport; Region: 2A0115; TIGR00895 596153005410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153005411 putative substrate translocation pore; other site 596153005412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153005413 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 596153005414 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 596153005415 Zn binding site [ion binding]; other site 596153005416 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 596153005417 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153005418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153005419 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 596153005420 putative dimerization interface [polypeptide binding]; other site 596153005421 2-isopropylmalate synthase; Validated; Region: PRK03739 596153005422 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 596153005423 active site 596153005424 catalytic residues [active] 596153005425 metal binding site [ion binding]; metal-binding site 596153005426 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 596153005427 2-isopropylmalate synthase; Validated; Region: PRK00915 596153005428 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 596153005429 active site 596153005430 catalytic residues [active] 596153005431 metal binding site [ion binding]; metal-binding site 596153005432 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 596153005433 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 596153005434 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 596153005435 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 596153005436 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153005437 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153005438 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 596153005439 Na binding site [ion binding]; other site 596153005440 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 596153005441 Predicted transcriptional regulator [Transcription]; Region: COG3905 596153005442 Proline dehydrogenase; Region: Pro_dh; pfam01619 596153005443 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 596153005444 NAD(P) binding site [chemical binding]; other site 596153005445 catalytic residues [active] 596153005446 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 596153005447 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153005448 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 596153005449 FAD binding site [chemical binding]; other site 596153005450 substrate binding site [chemical binding]; other site 596153005451 catalytic base [active] 596153005452 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 596153005453 Phosphotransferase enzyme family; Region: APH; pfam01636 596153005454 putative active site [active] 596153005455 putative substrate binding site [chemical binding]; other site 596153005456 ATP binding site [chemical binding]; other site 596153005457 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 596153005458 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 596153005459 ligand binding site [chemical binding]; other site 596153005460 flexible hinge region; other site 596153005461 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 596153005462 enoyl-CoA hydratase; Provisional; Region: PRK07511 596153005463 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153005464 substrate binding site [chemical binding]; other site 596153005465 oxyanion hole (OAH) forming residues; other site 596153005466 trimer interface [polypeptide binding]; other site 596153005467 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 596153005468 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 596153005469 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 596153005470 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 596153005471 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 596153005472 thiamine phosphate binding site [chemical binding]; other site 596153005473 active site 596153005474 pyrophosphate binding site [ion binding]; other site 596153005475 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 596153005476 ThiS interaction site; other site 596153005477 putative active site [active] 596153005478 tetramer interface [polypeptide binding]; other site 596153005479 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 596153005480 thiS-thiF/thiG interaction site; other site 596153005481 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 596153005482 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 596153005483 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 596153005484 dimer interface [polypeptide binding]; other site 596153005485 substrate binding site [chemical binding]; other site 596153005486 ATP binding site [chemical binding]; other site 596153005487 Bacterial SH3 domain; Region: SH3_4; pfam06347 596153005488 Bacterial SH3 domain; Region: SH3_3; pfam08239 596153005489 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 596153005490 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 596153005491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 596153005492 Ferredoxin [Energy production and conversion]; Region: COG1146 596153005493 4Fe-4S binding domain; Region: Fer4; cl02805 596153005494 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 596153005495 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 596153005496 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 596153005497 G1 box; other site 596153005498 GTP/Mg2+ binding site [chemical binding]; other site 596153005499 G2 box; other site 596153005500 Switch I region; other site 596153005501 G3 box; other site 596153005502 Switch II region; other site 596153005503 G4 box; other site 596153005504 G5 box; other site 596153005505 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 596153005506 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 596153005507 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 596153005508 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 596153005509 Active Sites [active] 596153005510 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 596153005511 Active Sites [active] 596153005512 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 596153005513 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 596153005514 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 596153005515 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 596153005516 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 596153005517 Uncharacterized conserved protein [Function unknown]; Region: COG4121 596153005518 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 596153005519 Predicted membrane protein [Function unknown]; Region: COG2860 596153005520 UPF0126 domain; Region: UPF0126; pfam03458 596153005521 UPF0126 domain; Region: UPF0126; pfam03458 596153005522 oxidative damage protection protein; Provisional; Region: PRK05408 596153005523 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 596153005524 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 596153005525 substrate binding pocket [chemical binding]; other site 596153005526 membrane-bound complex binding site; other site 596153005527 hinge residues; other site 596153005528 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 596153005529 acyl-CoA synthetase; Validated; Region: PRK06188 596153005530 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153005531 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 596153005532 acyl-activating enzyme (AAE) consensus motif; other site 596153005533 acyl-activating enzyme (AAE) consensus motif; other site 596153005534 putative AMP binding site [chemical binding]; other site 596153005535 putative active site [active] 596153005536 putative CoA binding site [chemical binding]; other site 596153005537 lipid-transfer protein; Provisional; Region: PRK08256 596153005538 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 596153005539 active site 596153005540 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 596153005541 classical (c) SDRs; Region: SDR_c; cd05233 596153005542 NAD(P) binding site [chemical binding]; other site 596153005543 active site 596153005544 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153005545 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 596153005546 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 596153005547 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 596153005548 TM-ABC transporter signature motif; other site 596153005549 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 596153005550 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 596153005551 TM-ABC transporter signature motif; other site 596153005552 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 596153005553 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 596153005554 Walker A/P-loop; other site 596153005555 ATP binding site [chemical binding]; other site 596153005556 Q-loop/lid; other site 596153005557 ABC transporter signature motif; other site 596153005558 Walker B; other site 596153005559 D-loop; other site 596153005560 H-loop/switch region; other site 596153005561 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 596153005562 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 596153005563 Walker A/P-loop; other site 596153005564 ATP binding site [chemical binding]; other site 596153005565 Q-loop/lid; other site 596153005566 ABC transporter signature motif; other site 596153005567 Walker B; other site 596153005568 D-loop; other site 596153005569 H-loop/switch region; other site 596153005570 Uncharacterized conserved protein [Function unknown]; Region: COG2128 596153005571 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 596153005572 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153005573 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 596153005574 acyl-activating enzyme (AAE) consensus motif; other site 596153005575 putative AMP binding site [chemical binding]; other site 596153005576 putative active site [active] 596153005577 putative CoA binding site [chemical binding]; other site 596153005578 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 596153005579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153005580 NAD(P) binding site [chemical binding]; other site 596153005581 active site 596153005582 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 596153005583 Sel1 repeat; Region: Sel1; cl02723 596153005584 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 596153005585 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 596153005586 N-acetyl-D-glucosamine binding site [chemical binding]; other site 596153005587 catalytic residue [active] 596153005588 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 596153005589 Transposase; Region: HTH_Tnp_1; cl17663 596153005590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153005591 putative transposase OrfB; Reviewed; Region: PHA02517 596153005592 HTH-like domain; Region: HTH_21; pfam13276 596153005593 Integrase core domain; Region: rve; pfam00665 596153005594 Integrase core domain; Region: rve_3; cl15866 596153005595 putative mercuric reductase; Provisional; Region: PRK13748 596153005596 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 596153005597 metal-binding site [ion binding] 596153005598 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 596153005599 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 596153005600 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 596153005601 metal-binding site [ion binding] 596153005602 putative mercuric transport protein; Provisional; Region: PRK13751 596153005603 putative transcriptional regulator MerR; Provisional; Region: PRK13752 596153005604 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 596153005605 DNA binding residues [nucleotide binding] 596153005606 dimer interface [polypeptide binding]; other site 596153005607 mercury binding site [ion binding]; other site 596153005608 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 596153005609 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 596153005610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153005611 S-adenosylmethionine binding site [chemical binding]; other site 596153005612 DEAD-like helicases superfamily; Region: DEXDc; smart00487 596153005613 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 596153005614 ATP binding site [chemical binding]; other site 596153005615 putative transposase OrfB; Reviewed; Region: PHA02517 596153005616 HTH-like domain; Region: HTH_21; pfam13276 596153005617 Integrase core domain; Region: rve; pfam00665 596153005618 Integrase core domain; Region: rve_3; cl15866 596153005619 Transposase; Region: HTH_Tnp_1; cl17663 596153005620 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153005621 integrase; Provisional; Region: PRK09692 596153005622 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 596153005623 active site 596153005624 Int/Topo IB signature motif; other site 596153005625 Transcriptional regulator; Region: Rrf2; cl17282 596153005626 Rrf2 family protein; Region: rrf2_super; TIGR00738 596153005627 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 596153005628 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 596153005629 HPP family; Region: HPP; pfam04982 596153005630 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 596153005631 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 596153005632 rRNA binding site [nucleotide binding]; other site 596153005633 predicted 30S ribosome binding site; other site 596153005634 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153005635 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153005636 metal binding site [ion binding]; metal-binding site 596153005637 active site 596153005638 I-site; other site 596153005639 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 596153005640 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 596153005641 IHF dimer interface [polypeptide binding]; other site 596153005642 IHF - DNA interface [nucleotide binding]; other site 596153005643 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 596153005644 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 596153005645 RNA binding site [nucleotide binding]; other site 596153005646 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 596153005647 RNA binding site [nucleotide binding]; other site 596153005648 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 596153005649 RNA binding site [nucleotide binding]; other site 596153005650 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 596153005651 RNA binding site [nucleotide binding]; other site 596153005652 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 596153005653 RNA binding site [nucleotide binding]; other site 596153005654 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 596153005655 RNA binding site [nucleotide binding]; other site 596153005656 bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidine monophosphate kinase; Provisional; Region: PRK11860 596153005657 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 596153005658 hinge; other site 596153005659 active site 596153005660 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 596153005661 CMP-binding site; other site 596153005662 The sites determining sugar specificity; other site 596153005663 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 596153005664 prephenate dehydrogenase; Validated; Region: PRK08507 596153005665 Chorismate mutase type II; Region: CM_2; pfam01817 596153005666 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 596153005667 Prephenate dehydratase; Region: PDT; pfam00800 596153005668 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 596153005669 putative L-Phe binding site [chemical binding]; other site 596153005670 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 596153005671 homodimer interface [polypeptide binding]; other site 596153005672 substrate-cofactor binding pocket; other site 596153005673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153005674 catalytic residue [active] 596153005675 DNA gyrase subunit A; Validated; Region: PRK05560 596153005676 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 596153005677 CAP-like domain; other site 596153005678 active site 596153005679 primary dimer interface [polypeptide binding]; other site 596153005680 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 596153005681 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 596153005682 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 596153005683 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 596153005684 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 596153005685 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 596153005686 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 596153005687 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 596153005688 ligand binding site [chemical binding]; other site 596153005689 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 596153005690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153005691 S-adenosylmethionine binding site [chemical binding]; other site 596153005692 phosphoglycolate phosphatase; Provisional; Region: PRK13222 596153005693 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 596153005694 motif II; other site 596153005695 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 596153005696 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 596153005697 Catalytic site [active] 596153005698 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 596153005699 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 596153005700 active site 596153005701 DNA binding site [nucleotide binding] 596153005702 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 596153005703 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 596153005704 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 596153005705 catalytic residues [active] 596153005706 catalytic nucleophile [active] 596153005707 Presynaptic Site I dimer interface [polypeptide binding]; other site 596153005708 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 596153005709 Synaptic Flat tetramer interface [polypeptide binding]; other site 596153005710 Synaptic Site I dimer interface [polypeptide binding]; other site 596153005711 DNA binding site [nucleotide binding] 596153005712 Recombinase; Region: Recombinase; pfam07508 596153005713 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 596153005714 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 596153005715 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 596153005716 non-specific DNA binding site [nucleotide binding]; other site 596153005717 salt bridge; other site 596153005718 sequence-specific DNA binding site [nucleotide binding]; other site 596153005719 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 596153005720 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 596153005721 Transposase; Region: HTH_Tnp_1; pfam01527 596153005722 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153005723 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 596153005724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 596153005725 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 596153005726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 596153005727 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 596153005728 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 596153005729 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 596153005730 putative transposase OrfB; Reviewed; Region: PHA02517 596153005731 HTH-like domain; Region: HTH_21; pfam13276 596153005732 Integrase core domain; Region: rve; pfam00665 596153005733 Integrase core domain; Region: rve_3; cl15866 596153005734 Transposase; Region: HTH_Tnp_1; cl17663 596153005735 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153005736 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 596153005737 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 596153005738 hydroxyglutarate oxidase; Provisional; Region: PRK11728 596153005739 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 596153005740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153005741 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 596153005742 putative dimerization interface [polypeptide binding]; other site 596153005743 glutaminase; Provisional; Region: PRK00971 596153005744 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 596153005745 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 596153005746 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 596153005747 metal binding site [ion binding]; metal-binding site 596153005748 putative dimer interface [polypeptide binding]; other site 596153005749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153005750 metabolite-proton symporter; Region: 2A0106; TIGR00883 596153005751 putative substrate translocation pore; other site 596153005752 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153005753 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153005754 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 596153005755 dimerization interface [polypeptide binding]; other site 596153005756 Helix-turn-helix domain; Region: HTH_17; pfam12728 596153005757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 596153005758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 596153005759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153005760 Major Facilitator Superfamily; Region: MFS_1; pfam07690 596153005761 putative substrate translocation pore; other site 596153005762 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 596153005763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153005764 NAD(P) binding site [chemical binding]; other site 596153005765 active site 596153005766 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 596153005767 CoenzymeA binding site [chemical binding]; other site 596153005768 subunit interaction site [polypeptide binding]; other site 596153005769 PHB binding site; other site 596153005770 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 596153005771 Prostaglandin dehydrogenases; Region: PGDH; cd05288 596153005772 NAD(P) binding site [chemical binding]; other site 596153005773 substrate binding site [chemical binding]; other site 596153005774 dimer interface [polypeptide binding]; other site 596153005775 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 596153005776 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 596153005777 C-terminal domain interface [polypeptide binding]; other site 596153005778 GSH binding site (G-site) [chemical binding]; other site 596153005779 dimer interface [polypeptide binding]; other site 596153005780 Glutathione S-transferase, C-terminal domain; Region: GST_C_2; pfam13410 596153005781 N-terminal domain interface [polypeptide binding]; other site 596153005782 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 596153005783 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 596153005784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153005785 putative substrate translocation pore; other site 596153005786 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 596153005787 DNA photolyase; Region: DNA_photolyase; pfam00875 596153005788 Predicted integral membrane protein [Function unknown]; Region: COG5615 596153005789 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 596153005790 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 596153005791 THF binding site; other site 596153005792 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 596153005793 substrate binding site [chemical binding]; other site 596153005794 THF binding site; other site 596153005795 zinc-binding site [ion binding]; other site 596153005796 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 596153005797 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153005798 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 596153005799 putative dimerization interface [polypeptide binding]; other site 596153005800 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 596153005801 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 596153005802 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 596153005803 tetramer interface [polypeptide binding]; other site 596153005804 active site 596153005805 Mg2+/Mn2+ binding site [ion binding]; other site 596153005806 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 596153005807 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 596153005808 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 596153005809 substrate binding site [chemical binding]; other site 596153005810 ligand binding site [chemical binding]; other site 596153005811 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 596153005812 substrate binding site [chemical binding]; other site 596153005813 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 596153005814 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 596153005815 dimer interface [polypeptide binding]; other site 596153005816 active site 596153005817 citrylCoA binding site [chemical binding]; other site 596153005818 oxalacetate/citrate binding site [chemical binding]; other site 596153005819 coenzyme A binding site [chemical binding]; other site 596153005820 catalytic triad [active] 596153005821 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 596153005822 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 596153005823 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 596153005824 sequence-specific DNA binding site [nucleotide binding]; other site 596153005825 salt bridge; other site 596153005826 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 596153005827 Domain of unknown function (DUF955); Region: DUF955; pfam06114 596153005828 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 596153005829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153005830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153005831 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 596153005832 putative dimerization interface [polypeptide binding]; other site 596153005833 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 596153005834 dimer interface [polypeptide binding]; other site 596153005835 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 596153005836 metal binding site [ion binding]; metal-binding site 596153005837 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-1; cd12808 596153005838 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 596153005839 catalytic site [active] 596153005840 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 596153005841 RNA binding surface [nucleotide binding]; other site 596153005842 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 596153005843 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153005844 dimer interface [polypeptide binding]; other site 596153005845 phosphorylation site [posttranslational modification] 596153005846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153005847 ATP binding site [chemical binding]; other site 596153005848 Mg2+ binding site [ion binding]; other site 596153005849 G-X-G motif; other site 596153005850 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 596153005851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153005852 active site 596153005853 phosphorylation site [posttranslational modification] 596153005854 intermolecular recognition site; other site 596153005855 dimerization interface [polypeptide binding]; other site 596153005856 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 596153005857 DNA binding site [nucleotide binding] 596153005858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153005859 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 596153005860 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 596153005861 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 596153005862 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 596153005863 putative inner membrane protein; Provisional; Region: PRK11099 596153005864 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 596153005865 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 596153005866 active site residue [active] 596153005867 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 596153005868 active site residue [active] 596153005869 ferrochelatase; Reviewed; Region: hemH; PRK00035 596153005870 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 596153005871 C-terminal domain interface [polypeptide binding]; other site 596153005872 active site 596153005873 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 596153005874 active site 596153005875 N-terminal domain interface [polypeptide binding]; other site 596153005876 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 596153005877 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 596153005878 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 596153005879 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 596153005880 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 596153005881 Soluble P-type ATPase [General function prediction only]; Region: COG4087 596153005882 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 596153005883 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 596153005884 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 596153005885 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 596153005886 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 596153005887 homodimer interface [polypeptide binding]; other site 596153005888 substrate-cofactor binding pocket; other site 596153005889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153005890 catalytic residue [active] 596153005891 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 596153005892 FOG: CBS domain [General function prediction only]; Region: COG0517 596153005893 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 596153005894 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 596153005895 Tetramer interface [polypeptide binding]; other site 596153005896 active site 596153005897 FMN-binding site [chemical binding]; other site 596153005898 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 596153005899 ATP cone domain; Region: ATP-cone; pfam03477 596153005900 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 596153005901 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 596153005902 dimer interface [polypeptide binding]; other site 596153005903 active site 596153005904 glycine-pyridoxal phosphate binding site [chemical binding]; other site 596153005905 folate binding site [chemical binding]; other site 596153005906 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 596153005907 N-acetyl-D-glucosamine binding site [chemical binding]; other site 596153005908 catalytic residue [active] 596153005909 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 596153005910 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 596153005911 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 596153005912 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 596153005913 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 596153005914 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 596153005915 ribonuclease R; Region: RNase_R; TIGR02063 596153005916 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 596153005917 RNB domain; Region: RNB; pfam00773 596153005918 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 596153005919 RNA binding site [nucleotide binding]; other site 596153005920 classical (c) SDRs; Region: SDR_c; cd05233 596153005921 NAD(P) binding site [chemical binding]; other site 596153005922 active site 596153005923 Cytochrome c; Region: Cytochrom_C; cl11414 596153005924 Cytochrome c; Region: Cytochrom_C; cl11414 596153005925 Cytochrome c; Region: Cytochrom_C; pfam00034 596153005926 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 596153005927 Cytochrome c; Region: Cytochrom_C; pfam00034 596153005928 Cytochrome c; Region: Cytochrom_C; pfam00034 596153005929 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 596153005930 catalytic residues [active] 596153005931 ribosome maturation protein RimP; Reviewed; Region: PRK00092 596153005932 Sm and related proteins; Region: Sm_like; cl00259 596153005933 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 596153005934 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 596153005935 NusA N-terminal domain; Region: NusA_N; pfam08529 596153005936 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 596153005937 RNA binding site [nucleotide binding]; other site 596153005938 homodimer interface [polypeptide binding]; other site 596153005939 NusA-like KH domain; Region: KH_5; pfam13184 596153005940 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 596153005941 G-X-X-G motif; other site 596153005942 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 596153005943 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 596153005944 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 596153005945 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 596153005946 translation initiation factor IF-2; Region: IF-2; TIGR00487 596153005947 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 596153005948 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 596153005949 G1 box; other site 596153005950 putative GEF interaction site [polypeptide binding]; other site 596153005951 GTP/Mg2+ binding site [chemical binding]; other site 596153005952 Switch I region; other site 596153005953 G2 box; other site 596153005954 G3 box; other site 596153005955 Switch II region; other site 596153005956 G4 box; other site 596153005957 G5 box; other site 596153005958 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 596153005959 Translation-initiation factor 2; Region: IF-2; pfam11987 596153005960 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 596153005961 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 596153005962 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 596153005963 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 596153005964 RNA binding site [nucleotide binding]; other site 596153005965 active site 596153005966 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 596153005967 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 596153005968 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 596153005969 G1 box; other site 596153005970 putative GEF interaction site [polypeptide binding]; other site 596153005971 GTP/Mg2+ binding site [chemical binding]; other site 596153005972 Switch I region; other site 596153005973 G2 box; other site 596153005974 G3 box; other site 596153005975 Switch II region; other site 596153005976 G4 box; other site 596153005977 G5 box; other site 596153005978 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 596153005979 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 596153005980 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 596153005981 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 596153005982 Leucine carboxyl methyltransferase; Region: LCM; cl01306 596153005983 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 596153005984 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153005985 substrate binding site [chemical binding]; other site 596153005986 oxyanion hole (OAH) forming residues; other site 596153005987 trimer interface [polypeptide binding]; other site 596153005988 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 596153005989 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 596153005990 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 596153005991 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 596153005992 DNA binding residues [nucleotide binding] 596153005993 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 596153005994 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 596153005995 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 596153005996 SmpB-tmRNA interface; other site 596153005997 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 596153005998 putative coenzyme Q binding site [chemical binding]; other site 596153005999 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 596153006000 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 596153006001 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 596153006002 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 596153006003 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 596153006004 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 596153006005 active site 596153006006 GMP synthase; Reviewed; Region: guaA; PRK00074 596153006007 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 596153006008 AMP/PPi binding site [chemical binding]; other site 596153006009 candidate oxyanion hole; other site 596153006010 catalytic triad [active] 596153006011 potential glutamine specificity residues [chemical binding]; other site 596153006012 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 596153006013 ATP Binding subdomain [chemical binding]; other site 596153006014 Ligand Binding sites [chemical binding]; other site 596153006015 Dimerization subdomain; other site 596153006016 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 596153006017 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 596153006018 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 596153006019 dimer interface [polypeptide binding]; other site 596153006020 active site 596153006021 citrylCoA binding site [chemical binding]; other site 596153006022 NADH binding [chemical binding]; other site 596153006023 cationic pore residues; other site 596153006024 oxalacetate/citrate binding site [chemical binding]; other site 596153006025 coenzyme A binding site [chemical binding]; other site 596153006026 catalytic triad [active] 596153006027 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 596153006028 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 596153006029 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 596153006030 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 596153006031 L-aspartate oxidase; Provisional; Region: PRK06175 596153006032 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 596153006033 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 596153006034 SdhC subunit interface [polypeptide binding]; other site 596153006035 proximal heme binding site [chemical binding]; other site 596153006036 cardiolipin binding site; other site 596153006037 Iron-sulfur protein interface; other site 596153006038 proximal quinone binding site [chemical binding]; other site 596153006039 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 596153006040 Iron-sulfur protein interface; other site 596153006041 proximal quinone binding site [chemical binding]; other site 596153006042 SdhD (CybS) interface [polypeptide binding]; other site 596153006043 proximal heme binding site [chemical binding]; other site 596153006044 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 596153006045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153006046 DNA-binding site [nucleotide binding]; DNA binding site 596153006047 UTRA domain; Region: UTRA; pfam07702 596153006048 malate dehydrogenase; Provisional; Region: PRK05442 596153006049 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 596153006050 NAD(P) binding site [chemical binding]; other site 596153006051 dimer interface [polypeptide binding]; other site 596153006052 malate binding site [chemical binding]; other site 596153006053 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 596153006054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153006055 S-adenosylmethionine binding site [chemical binding]; other site 596153006056 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 596153006057 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 596153006058 substrate binding site [chemical binding]; other site 596153006059 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 596153006060 substrate binding site [chemical binding]; other site 596153006061 ligand binding site [chemical binding]; other site 596153006062 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 596153006063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153006064 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153006065 dimerization interface [polypeptide binding]; other site 596153006066 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153006067 active site 596153006068 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153006069 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153006070 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153006071 glutathione reductase; Validated; Region: PRK06116 596153006072 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 596153006073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 596153006074 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 596153006075 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 596153006076 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 596153006077 catalytic loop [active] 596153006078 iron binding site [ion binding]; other site 596153006079 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 596153006080 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 596153006081 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 596153006082 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 596153006083 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 596153006084 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 596153006085 MoxR-like ATPases [General function prediction only]; Region: COG0714 596153006086 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 596153006087 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 596153006088 metal ion-dependent adhesion site (MIDAS); other site 596153006089 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 596153006090 putative hydrophobic ligand binding site [chemical binding]; other site 596153006091 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 596153006092 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 596153006093 XdhC Rossmann domain; Region: XdhC_C; pfam13478 596153006094 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 596153006095 metal-binding site 596153006096 hypothetical protein; Provisional; Region: PRK07233 596153006097 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 596153006098 hydroxyglutarate oxidase; Provisional; Region: PRK11728 596153006099 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 596153006100 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 596153006101 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 596153006102 Ligand binding site; other site 596153006103 Putative Catalytic site; other site 596153006104 DXD motif; other site 596153006105 putative protease; Provisional; Region: PRK15452 596153006106 Peptidase family U32; Region: Peptidase_U32; pfam01136 596153006107 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153006108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153006109 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153006110 dimerization interface [polypeptide binding]; other site 596153006111 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 596153006112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153006113 active site 596153006114 phosphorylation site [posttranslational modification] 596153006115 intermolecular recognition site; other site 596153006116 dimerization interface [polypeptide binding]; other site 596153006117 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 596153006118 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 596153006119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153006120 dimer interface [polypeptide binding]; other site 596153006121 phosphorylation site [posttranslational modification] 596153006122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153006123 ATP binding site [chemical binding]; other site 596153006124 Mg2+ binding site [ion binding]; other site 596153006125 G-X-G motif; other site 596153006126 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 596153006127 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 596153006128 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 596153006129 Subunit I/III interface [polypeptide binding]; other site 596153006130 Subunit III/IV interface [polypeptide binding]; other site 596153006131 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 596153006132 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 596153006133 D-pathway; other site 596153006134 Putative ubiquinol binding site [chemical binding]; other site 596153006135 Low-spin heme (heme b) binding site [chemical binding]; other site 596153006136 Putative water exit pathway; other site 596153006137 Binuclear center (heme o3/CuB) [ion binding]; other site 596153006138 K-pathway; other site 596153006139 Putative proton exit pathway; other site 596153006140 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 596153006141 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 596153006142 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 596153006143 metabolite-proton symporter; Region: 2A0106; TIGR00883 596153006144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153006145 TolA protein; Region: tolA_full; TIGR02794 596153006146 TonB C terminal; Region: TonB_2; pfam13103 596153006147 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 596153006148 TolR protein; Region: tolR; TIGR02801 596153006149 TolQ protein; Region: tolQ; TIGR02796 596153006150 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 596153006151 active site 596153006152 aminotransferase; Validated; Region: PRK07337 596153006153 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 596153006154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153006155 homodimer interface [polypeptide binding]; other site 596153006156 catalytic residue [active] 596153006157 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 596153006158 putative RNA binding site [nucleotide binding]; other site 596153006159 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 596153006160 homopentamer interface [polypeptide binding]; other site 596153006161 active site 596153006162 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 596153006163 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 596153006164 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 596153006165 dimerization interface [polypeptide binding]; other site 596153006166 active site 596153006167 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 596153006168 catalytic loop [active] 596153006169 iron binding site [ion binding]; other site 596153006170 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 596153006171 homodimer interface [polypeptide binding]; other site 596153006172 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 596153006173 NAD binding site [chemical binding]; other site 596153006174 active site 596153006175 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 596153006176 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 596153006177 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 596153006178 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 596153006179 homotrimer interaction site [polypeptide binding]; other site 596153006180 putative active site [active] 596153006181 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 596153006182 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 596153006183 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 596153006184 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 596153006185 catalytic loop [active] 596153006186 iron binding site [ion binding]; other site 596153006187 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 596153006188 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153006189 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153006190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153006191 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153006192 dimerization interface [polypeptide binding]; other site 596153006193 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 596153006194 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 596153006195 GTP/Mg2+ binding site [chemical binding]; other site 596153006196 G4 box; other site 596153006197 G5 box; other site 596153006198 G1 box; other site 596153006199 Switch I region; other site 596153006200 G2 box; other site 596153006201 G3 box; other site 596153006202 Switch II region; other site 596153006203 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 596153006204 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 596153006205 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 596153006206 active site 596153006207 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 596153006208 enterobactin exporter EntS; Provisional; Region: PRK10489 596153006209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153006210 putative substrate translocation pore; other site 596153006211 Staphylococcal nuclease homologues; Region: SNc; smart00318 596153006212 Catalytic site; other site 596153006213 Staphylococcal nuclease homologue; Region: SNase; pfam00565 596153006214 Predicted permeases [General function prediction only]; Region: RarD; COG2962 596153006215 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 596153006216 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 596153006217 pseudouridine synthase; Region: TIGR00093 596153006218 active site 596153006219 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 596153006220 Peptidase family M23; Region: Peptidase_M23; pfam01551 596153006221 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 596153006222 Aspartase; Region: Aspartase; cd01357 596153006223 active sites [active] 596153006224 tetramer interface [polypeptide binding]; other site 596153006225 META domain; Region: META; pfam03724 596153006226 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 596153006227 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 596153006228 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 596153006229 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 596153006230 active site 596153006231 HIGH motif; other site 596153006232 nucleotide binding site [chemical binding]; other site 596153006233 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 596153006234 active site 596153006235 KMSKS motif; other site 596153006236 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 596153006237 Dehydroquinase class II; Region: DHquinase_II; pfam01220 596153006238 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 596153006239 trimer interface [polypeptide binding]; other site 596153006240 active site 596153006241 dimer interface [polypeptide binding]; other site 596153006242 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 596153006243 hypothetical protein; Provisional; Region: PRK09256 596153006244 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 596153006245 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 596153006246 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 596153006247 putative active site [active] 596153006248 metal binding site [ion binding]; metal-binding site 596153006249 Predicted esterase [General function prediction only]; Region: COG0400 596153006250 putative hydrolase; Provisional; Region: PRK11460 596153006251 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 596153006252 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 596153006253 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 596153006254 putative DNA binding site [nucleotide binding]; other site 596153006255 putative Zn2+ binding site [ion binding]; other site 596153006256 AsnC family; Region: AsnC_trans_reg; pfam01037 596153006257 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 596153006258 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 596153006259 dimer interface [polypeptide binding]; other site 596153006260 TPP-binding site [chemical binding]; other site 596153006261 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 596153006262 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 596153006263 Amidase; Region: Amidase; cl11426 596153006264 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153006265 Mor transcription activator family; Region: Mor; cl02360 596153006266 Protein of unknown function (DUF1018); Region: DUF1018; pfam06252 596153006267 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 596153006268 IHF dimer interface [polypeptide binding]; other site 596153006269 IHF - DNA interface [nucleotide binding]; other site 596153006270 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 596153006271 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 596153006272 HTH domain; Region: HTH_22; pfam13309 596153006273 Integrase core domain; Region: rve; pfam00665 596153006274 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 596153006275 transcriptional repressor UlaR; Provisional; Region: PRK13509 596153006276 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 596153006277 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 596153006278 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 596153006279 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 596153006280 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 596153006281 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 596153006282 N-acetyl-D-glucosamine binding site [chemical binding]; other site 596153006283 catalytic residue [active] 596153006284 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 596153006285 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 596153006286 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 596153006287 Terminase-like family; Region: Terminase_6; pfam03237 596153006288 Protein of unknown function (DUF935); Region: DUF935; pfam06074 596153006289 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 596153006290 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 596153006291 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 596153006292 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 596153006293 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 596153006294 Protein of unknown function (DUF1320); Region: DUF1320; cl01818 596153006295 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 596153006296 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 596153006297 Phage-related minor tail protein [Function unknown]; Region: COG5281 596153006298 Transposase domain (DUF772); Region: DUF772; pfam05598 596153006299 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 596153006300 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 596153006301 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 596153006302 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153006303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153006304 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 596153006305 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 596153006306 dimerization interface [polypeptide binding]; other site 596153006307 substrate binding pocket [chemical binding]; other site 596153006308 Transcriptional regulators [Transcription]; Region: FadR; COG2186 596153006309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153006310 DNA-binding site [nucleotide binding]; DNA binding site 596153006311 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 596153006312 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 596153006313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153006314 putative substrate translocation pore; other site 596153006315 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 596153006316 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 596153006317 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 596153006318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153006319 NAD(P) binding site [chemical binding]; other site 596153006320 active site 596153006321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 596153006322 putative aldolase; Validated; Region: PRK08130 596153006323 intersubunit interface [polypeptide binding]; other site 596153006324 active site 596153006325 Zn2+ binding site [ion binding]; other site 596153006326 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 596153006327 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 596153006328 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 596153006329 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 596153006330 putative active site [active] 596153006331 putative metal binding site [ion binding]; other site 596153006332 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 596153006333 substrate binding site [chemical binding]; other site 596153006334 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 596153006335 substrate binding site [chemical binding]; other site 596153006336 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 596153006337 TPR repeat; Region: TPR_11; pfam13414 596153006338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 596153006339 binding surface 596153006340 TPR motif; other site 596153006341 TPR repeat; Region: TPR_11; pfam13414 596153006342 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 596153006343 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 596153006344 active site 596153006345 HIGH motif; other site 596153006346 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 596153006347 KMSKS motif; other site 596153006348 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 596153006349 tRNA binding surface [nucleotide binding]; other site 596153006350 anticodon binding site; other site 596153006351 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 596153006352 endonuclease III; Region: ENDO3c; smart00478 596153006353 minor groove reading motif; other site 596153006354 helix-hairpin-helix signature motif; other site 596153006355 substrate binding pocket [chemical binding]; other site 596153006356 active site 596153006357 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 596153006358 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 596153006359 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 596153006360 Ligand Binding Site [chemical binding]; other site 596153006361 aspartate kinase; Reviewed; Region: PRK06635 596153006362 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 596153006363 putative nucleotide binding site [chemical binding]; other site 596153006364 putative catalytic residues [active] 596153006365 putative Mg ion binding site [ion binding]; other site 596153006366 putative aspartate binding site [chemical binding]; other site 596153006367 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 596153006368 putative allosteric regulatory site; other site 596153006369 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 596153006370 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 596153006371 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 596153006372 putative ion selectivity filter; other site 596153006373 putative pore gating glutamate residue; other site 596153006374 putative H+/Cl- coupling transport residue; other site 596153006375 putative transposase OrfB; Reviewed; Region: PHA02517 596153006376 HTH-like domain; Region: HTH_21; pfam13276 596153006377 Integrase core domain; Region: rve; pfam00665 596153006378 Integrase core domain; Region: rve_3; cl15866 596153006379 Transposase; Region: HTH_Tnp_1; cl17663 596153006380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153006381 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 596153006382 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 596153006383 HlyD family secretion protein; Region: HlyD_3; pfam13437 596153006384 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 596153006385 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 596153006386 FtsX-like permease family; Region: FtsX; pfam02687 596153006387 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 596153006388 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 596153006389 Walker A/P-loop; other site 596153006390 ATP binding site [chemical binding]; other site 596153006391 Q-loop/lid; other site 596153006392 ABC transporter signature motif; other site 596153006393 Walker B; other site 596153006394 D-loop; other site 596153006395 H-loop/switch region; other site 596153006396 Transglycosylase SLT domain; Region: SLT_2; pfam13406 596153006397 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 596153006398 N-acetyl-D-glucosamine binding site [chemical binding]; other site 596153006399 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 596153006400 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 596153006401 exonuclease I; Provisional; Region: sbcB; PRK11779 596153006402 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 596153006403 active site 596153006404 catalytic site [active] 596153006405 substrate binding site [chemical binding]; other site 596153006406 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 596153006407 NAD-dependent deacetylase; Provisional; Region: PRK05333 596153006408 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 596153006409 NAD+ binding site [chemical binding]; other site 596153006410 substrate binding site [chemical binding]; other site 596153006411 Zn binding site [ion binding]; other site 596153006412 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 596153006413 Domain of unknown function DUF20; Region: UPF0118; pfam01594 596153006414 GAF domain; Region: GAF; pfam01590 596153006415 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 596153006416 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 596153006417 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 596153006418 active site 596153006419 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 596153006420 tetramer interface [polypeptide binding]; other site 596153006421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153006422 catalytic residue [active] 596153006423 hypothetical protein; Provisional; Region: PRK12378 596153006424 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 596153006425 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 596153006426 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 596153006427 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 596153006428 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 596153006429 LrgB-like family; Region: LrgB; cl00596 596153006430 LrgA family; Region: LrgA; pfam03788 596153006431 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 596153006432 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153006433 DNA-binding site [nucleotide binding]; DNA binding site 596153006434 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 596153006435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153006436 homodimer interface [polypeptide binding]; other site 596153006437 catalytic residue [active] 596153006438 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 596153006439 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 596153006440 C-terminal domain interface [polypeptide binding]; other site 596153006441 GSH binding site (G-site) [chemical binding]; other site 596153006442 dimer interface [polypeptide binding]; other site 596153006443 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 596153006444 N-terminal domain interface [polypeptide binding]; other site 596153006445 putative dimer interface [polypeptide binding]; other site 596153006446 active site 596153006447 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 596153006448 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 596153006449 hypothetical protein; Validated; Region: PRK00110 596153006450 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 596153006451 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 596153006452 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 596153006453 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 596153006454 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 596153006455 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 596153006456 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 596153006457 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 596153006458 Maf-like protein; Region: Maf; pfam02545 596153006459 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 596153006460 active site 596153006461 dimer interface [polypeptide binding]; other site 596153006462 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 596153006463 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 596153006464 ligand binding site [chemical binding]; other site 596153006465 flexible hinge region; other site 596153006466 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 596153006467 non-specific DNA interactions [nucleotide binding]; other site 596153006468 DNA binding site [nucleotide binding] 596153006469 sequence specific DNA binding site [nucleotide binding]; other site 596153006470 putative cAMP binding site [chemical binding]; other site 596153006471 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 596153006472 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 596153006473 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 596153006474 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 596153006475 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 596153006476 FeS/SAM binding site; other site 596153006477 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 596153006478 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 596153006479 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 596153006480 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 596153006481 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 596153006482 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 596153006483 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 596153006484 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 596153006485 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 596153006486 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 596153006487 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 596153006488 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 596153006489 active site 596153006490 SAM binding site [chemical binding]; other site 596153006491 homodimer interface [polypeptide binding]; other site 596153006492 ribonuclease G; Provisional; Region: PRK11712 596153006493 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 596153006494 homodimer interface [polypeptide binding]; other site 596153006495 oligonucleotide binding site [chemical binding]; other site 596153006496 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 596153006497 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153006498 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153006499 metal binding site [ion binding]; metal-binding site 596153006500 active site 596153006501 I-site; other site 596153006502 methionine aminotransferase; Validated; Region: PRK09082 596153006503 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 596153006504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153006505 homodimer interface [polypeptide binding]; other site 596153006506 catalytic residue [active] 596153006507 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 596153006508 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153006509 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 596153006510 substrate binding site [chemical binding]; other site 596153006511 dimerization interface [polypeptide binding]; other site 596153006512 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 596153006513 putative active site [active] 596153006514 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 596153006515 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 596153006516 Predicted permeases [General function prediction only]; Region: COG0795 596153006517 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 596153006518 multifunctional aminopeptidase A; Provisional; Region: PRK00913 596153006519 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 596153006520 interface (dimer of trimers) [polypeptide binding]; other site 596153006521 Substrate-binding/catalytic site; other site 596153006522 Zn-binding sites [ion binding]; other site 596153006523 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 596153006524 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 596153006525 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 596153006526 dimerization interface [polypeptide binding]; other site 596153006527 ligand binding site [chemical binding]; other site 596153006528 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 596153006529 dimerization interface [polypeptide binding]; other site 596153006530 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 596153006531 NAD binding site [chemical binding]; other site 596153006532 ligand binding site [chemical binding]; other site 596153006533 catalytic site [active] 596153006534 Biofilm formation and stress response factor; Region: BsmA; pfam10014 596153006535 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 596153006536 Ligand Binding Site [chemical binding]; other site 596153006537 Hemerythrin; Region: Hemerythrin; cd12107 596153006538 Fe binding site [ion binding]; other site 596153006539 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153006540 beta-ketothiolase; Provisional; Region: PRK09051 596153006541 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 596153006542 dimer interface [polypeptide binding]; other site 596153006543 active site 596153006544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153006545 short chain dehydrogenase; Provisional; Region: PRK07023 596153006546 NAD(P) binding site [chemical binding]; other site 596153006547 active site 596153006548 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 596153006549 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 596153006550 active site 596153006551 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 596153006552 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 596153006553 putative active site [active] 596153006554 heme pocket [chemical binding]; other site 596153006555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153006556 dimer interface [polypeptide binding]; other site 596153006557 phosphorylation site [posttranslational modification] 596153006558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153006559 ATP binding site [chemical binding]; other site 596153006560 Mg2+ binding site [ion binding]; other site 596153006561 G-X-G motif; other site 596153006562 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 596153006563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153006564 active site 596153006565 phosphorylation site [posttranslational modification] 596153006566 intermolecular recognition site; other site 596153006567 dimerization interface [polypeptide binding]; other site 596153006568 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 596153006569 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 596153006570 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 596153006571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153006572 active site 596153006573 phosphorylation site [posttranslational modification] 596153006574 intermolecular recognition site; other site 596153006575 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 596153006576 DNA binding residues [nucleotide binding] 596153006577 dimerization interface [polypeptide binding]; other site 596153006578 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 596153006579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153006580 ATP binding site [chemical binding]; other site 596153006581 Mg2+ binding site [ion binding]; other site 596153006582 G-X-G motif; other site 596153006583 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 596153006584 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 596153006585 catalytic residues [active] 596153006586 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 596153006587 Heavy-metal resistance; Region: Metal_resist; pfam13801 596153006588 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 596153006589 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 596153006590 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 596153006591 DNA binding residues [nucleotide binding] 596153006592 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 596153006593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153006594 S-adenosylmethionine binding site [chemical binding]; other site 596153006595 D-serine dehydratase; Provisional; Region: PRK02991 596153006596 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 596153006597 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 596153006598 catalytic residue [active] 596153006599 Uncharacterized conserved protein [Function unknown]; Region: COG1739 596153006600 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 596153006601 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 596153006602 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 596153006603 hypothetical protein; Provisional; Region: PRK01254 596153006604 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 596153006605 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 596153006606 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 596153006607 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 596153006608 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 596153006609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153006610 homodimer interface [polypeptide binding]; other site 596153006611 catalytic residue [active] 596153006612 excinuclease ABC subunit B; Provisional; Region: PRK05298 596153006613 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 596153006614 ATP binding site [chemical binding]; other site 596153006615 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 596153006616 nucleotide binding region [chemical binding]; other site 596153006617 ATP-binding site [chemical binding]; other site 596153006618 Ultra-violet resistance protein B; Region: UvrB; pfam12344 596153006619 UvrB/uvrC motif; Region: UVR; pfam02151 596153006620 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 596153006621 Rrf2 family protein; Region: rrf2_super; TIGR00738 596153006622 cysteine desulfurase; Provisional; Region: PRK14012 596153006623 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 596153006624 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 596153006625 catalytic residue [active] 596153006626 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 596153006627 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 596153006628 trimerization site [polypeptide binding]; other site 596153006629 active site 596153006630 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 596153006631 co-chaperone HscB; Provisional; Region: hscB; PRK03578 596153006632 DnaJ domain; Region: DnaJ; pfam00226 596153006633 HSP70 interaction site [polypeptide binding]; other site 596153006634 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 596153006635 chaperone protein HscA; Provisional; Region: hscA; PRK05183 596153006636 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 596153006637 nucleotide binding site [chemical binding]; other site 596153006638 putative NEF/HSP70 interaction site [polypeptide binding]; other site 596153006639 SBD interface [polypeptide binding]; other site 596153006640 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 596153006641 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 596153006642 catalytic loop [active] 596153006643 iron binding site [ion binding]; other site 596153006644 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 596153006645 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 596153006646 active site 596153006647 catalytic site [active] 596153006648 substrate binding site [chemical binding]; other site 596153006649 Predicted dehydrogenase [General function prediction only]; Region: COG0579 596153006650 hydroxyglutarate oxidase; Provisional; Region: PRK11728 596153006651 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 596153006652 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 596153006653 quinone interaction residues [chemical binding]; other site 596153006654 active site 596153006655 catalytic residues [active] 596153006656 FMN binding site [chemical binding]; other site 596153006657 substrate binding site [chemical binding]; other site 596153006658 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 596153006659 tetramer (dimer of dimers) interface [polypeptide binding]; other site 596153006660 active site 596153006661 dimer interface [polypeptide binding]; other site 596153006662 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 596153006663 catalytic residues [active] 596153006664 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 596153006665 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 596153006666 active site 596153006667 Zn binding site [ion binding]; other site 596153006668 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 596153006669 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 596153006670 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 596153006671 homodimer interface [polypeptide binding]; other site 596153006672 NADP binding site [chemical binding]; other site 596153006673 substrate binding site [chemical binding]; other site 596153006674 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 596153006675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153006676 active site 596153006677 phosphorylation site [posttranslational modification] 596153006678 intermolecular recognition site; other site 596153006679 dimerization interface [polypeptide binding]; other site 596153006680 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 596153006681 DNA binding residues [nucleotide binding] 596153006682 dimerization interface [polypeptide binding]; other site 596153006683 PAS domain S-box; Region: sensory_box; TIGR00229 596153006684 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153006685 putative active site [active] 596153006686 heme pocket [chemical binding]; other site 596153006687 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153006688 dimer interface [polypeptide binding]; other site 596153006689 phosphorylation site [posttranslational modification] 596153006690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153006691 ATP binding site [chemical binding]; other site 596153006692 Mg2+ binding site [ion binding]; other site 596153006693 G-X-G motif; other site 596153006694 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 596153006695 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 596153006696 dimer interface [polypeptide binding]; other site 596153006697 TPP-binding site [chemical binding]; other site 596153006698 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 596153006699 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 596153006700 E3 interaction surface; other site 596153006701 lipoyl attachment site [posttranslational modification]; other site 596153006702 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 596153006703 E3 interaction surface; other site 596153006704 lipoyl attachment site [posttranslational modification]; other site 596153006705 e3 binding domain; Region: E3_binding; pfam02817 596153006706 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 596153006707 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 596153006708 E3 interaction surface; other site 596153006709 lipoyl attachment site [posttranslational modification]; other site 596153006710 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 596153006711 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 596153006712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 596153006713 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 596153006714 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 596153006715 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153006716 Fic family protein [Function unknown]; Region: COG3177 596153006717 Fic/DOC family; Region: Fic; pfam02661 596153006718 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 596153006719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153006720 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 596153006721 dimerization interface [polypeptide binding]; other site 596153006722 substrate binding pocket [chemical binding]; other site 596153006723 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 596153006724 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 596153006725 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153006726 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 596153006727 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 596153006728 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 596153006729 EVE domain; Region: EVE; cl00728 596153006730 Transglycosylase associated protein; Region: Transgly_assoc; pfam04226 596153006731 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 596153006732 NlpC/P60 family; Region: NLPC_P60; pfam00877 596153006733 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 596153006734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153006735 putative substrate translocation pore; other site 596153006736 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 596153006737 PAS domain S-box; Region: sensory_box; TIGR00229 596153006738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153006739 putative active site [active] 596153006740 heme pocket [chemical binding]; other site 596153006741 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153006742 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153006743 metal binding site [ion binding]; metal-binding site 596153006744 active site 596153006745 I-site; other site 596153006746 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 596153006747 hypothetical protein; Provisional; Region: PRK02237 596153006748 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 596153006749 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 596153006750 Walker A/P-loop; other site 596153006751 ATP binding site [chemical binding]; other site 596153006752 Q-loop/lid; other site 596153006753 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 596153006754 Q-loop/lid; other site 596153006755 ABC transporter signature motif; other site 596153006756 Walker B; other site 596153006757 D-loop; other site 596153006758 H-loop/switch region; other site 596153006759 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 596153006760 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 596153006761 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 596153006762 nucleotide binding pocket [chemical binding]; other site 596153006763 K-X-D-G motif; other site 596153006764 catalytic site [active] 596153006765 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 596153006766 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 596153006767 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 596153006768 Dimer interface [polypeptide binding]; other site 596153006769 BRCT sequence motif; other site 596153006770 hypothetical protein; Provisional; Region: PRK10279 596153006771 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 596153006772 nucleophile elbow; other site 596153006773 Transglycosylase; Region: Transgly; pfam00912 596153006774 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 596153006775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153006776 Major Facilitator Superfamily; Region: MFS_1; pfam07690 596153006777 putative substrate translocation pore; other site 596153006778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153006779 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 596153006780 nudix motif; other site 596153006781 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 596153006782 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 596153006783 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 596153006784 maleylacetoacetate isomerase; Region: maiA; TIGR01262 596153006785 C-terminal domain interface [polypeptide binding]; other site 596153006786 GSH binding site (G-site) [chemical binding]; other site 596153006787 putative dimer interface [polypeptide binding]; other site 596153006788 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 596153006789 dimer interface [polypeptide binding]; other site 596153006790 N-terminal domain interface [polypeptide binding]; other site 596153006791 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 596153006792 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 596153006793 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 596153006794 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 596153006795 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 596153006796 putative acyltransferase; Provisional; Region: PRK05790 596153006797 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 596153006798 dimer interface [polypeptide binding]; other site 596153006799 active site 596153006800 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 596153006801 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 596153006802 NAD(P) binding site [chemical binding]; other site 596153006803 homotetramer interface [polypeptide binding]; other site 596153006804 homodimer interface [polypeptide binding]; other site 596153006805 active site 596153006806 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 596153006807 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 596153006808 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 596153006809 ABC transporter; Region: ABC_tran_2; pfam12848 596153006810 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 596153006811 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153006812 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153006813 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 596153006814 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 596153006815 active site 596153006816 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 596153006817 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153006818 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 596153006819 acyl-activating enzyme (AAE) consensus motif; other site 596153006820 acyl-activating enzyme (AAE) consensus motif; other site 596153006821 putative AMP binding site [chemical binding]; other site 596153006822 putative active site [active] 596153006823 putative CoA binding site [chemical binding]; other site 596153006824 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153006825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153006826 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 596153006827 dimerization interface [polypeptide binding]; other site 596153006828 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 596153006829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153006830 S-adenosylmethionine binding site [chemical binding]; other site 596153006831 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 596153006832 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 596153006833 metal binding site [ion binding]; metal-binding site 596153006834 dimer interface [polypeptide binding]; other site 596153006835 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 596153006836 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 596153006837 Walker A motif; other site 596153006838 ATP binding site [chemical binding]; other site 596153006839 Walker B motif; other site 596153006840 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 596153006841 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 596153006842 active site 596153006843 substrate binding site [chemical binding]; other site 596153006844 trimer interface [polypeptide binding]; other site 596153006845 CoA binding site [chemical binding]; other site 596153006846 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 596153006847 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 596153006848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153006849 homodimer interface [polypeptide binding]; other site 596153006850 catalytic residue [active] 596153006851 ferredoxin; Provisional; Region: PRK08764 596153006852 Putative Fe-S cluster; Region: FeS; cl17515 596153006853 4Fe-4S binding domain; Region: Fer4; pfam00037 596153006854 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 596153006855 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 596153006856 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 596153006857 synthetase active site [active] 596153006858 NTP binding site [chemical binding]; other site 596153006859 metal binding site [ion binding]; metal-binding site 596153006860 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 596153006861 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 596153006862 FMN binding site [chemical binding]; other site 596153006863 active site 596153006864 catalytic residues [active] 596153006865 substrate binding site [chemical binding]; other site 596153006866 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 596153006867 putative active site [active] 596153006868 putative catalytic site [active] 596153006869 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 596153006870 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 596153006871 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 596153006872 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 596153006873 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153006874 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 596153006875 acyl-activating enzyme (AAE) consensus motif; other site 596153006876 acyl-activating enzyme (AAE) consensus motif; other site 596153006877 putative AMP binding site [chemical binding]; other site 596153006878 putative active site [active] 596153006879 putative CoA binding site [chemical binding]; other site 596153006880 Transcriptional regulators [Transcription]; Region: GntR; COG1802 596153006881 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153006882 DNA-binding site [nucleotide binding]; DNA binding site 596153006883 FCD domain; Region: FCD; pfam07729 596153006884 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 596153006885 active site 596153006886 catalytic residues [active] 596153006887 metal binding site [ion binding]; metal-binding site 596153006888 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153006889 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153006890 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153006891 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 596153006892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 596153006893 non-specific DNA binding site [nucleotide binding]; other site 596153006894 salt bridge; other site 596153006895 sequence-specific DNA binding site [nucleotide binding]; other site 596153006896 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 596153006897 Domain of unknown function (DUF955); Region: DUF955; pfam06114 596153006898 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 596153006899 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 596153006900 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 596153006901 active site 596153006902 substrate binding site [chemical binding]; other site 596153006903 coenzyme B12 binding site [chemical binding]; other site 596153006904 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 596153006905 B12 binding site [chemical binding]; other site 596153006906 cobalt ligand [ion binding]; other site 596153006907 membrane ATPase/protein kinase; Provisional; Region: PRK09435 596153006908 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 596153006909 Walker A; other site 596153006910 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 596153006911 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 596153006912 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 596153006913 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 596153006914 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 596153006915 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 596153006916 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 596153006917 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 596153006918 carboxyltransferase (CT) interaction site; other site 596153006919 biotinylation site [posttranslational modification]; other site 596153006920 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 596153006921 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 596153006922 dimer interface [polypeptide binding]; other site 596153006923 substrate binding site [chemical binding]; other site 596153006924 metal binding site [ion binding]; metal-binding site 596153006925 biotin synthase; Region: bioB; TIGR00433 596153006926 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 596153006927 FeS/SAM binding site; other site 596153006928 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 596153006929 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153006930 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 596153006931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153006932 active site 596153006933 phosphorylation site [posttranslational modification] 596153006934 intermolecular recognition site; other site 596153006935 dimerization interface [polypeptide binding]; other site 596153006936 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 596153006937 DNA binding site [nucleotide binding] 596153006938 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 596153006939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 596153006940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153006941 dimer interface [polypeptide binding]; other site 596153006942 phosphorylation site [posttranslational modification] 596153006943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153006944 ATP binding site [chemical binding]; other site 596153006945 Mg2+ binding site [ion binding]; other site 596153006946 G-X-G motif; other site 596153006947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153006948 OsmC-like protein; Region: OsmC; pfam02566 596153006949 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 596153006950 active site residue [active] 596153006951 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 596153006952 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 596153006953 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 596153006954 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 596153006955 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 596153006956 Outer membrane efflux protein; Region: OEP; pfam02321 596153006957 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 596153006958 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 596153006959 Protein export membrane protein; Region: SecD_SecF; cl14618 596153006960 Protein export membrane protein; Region: SecD_SecF; cl14618 596153006961 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 596153006962 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 596153006963 HlyD family secretion protein; Region: HlyD_3; pfam13437 596153006964 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 596153006965 dimerization interface [polypeptide binding]; other site 596153006966 putative DNA binding site [nucleotide binding]; other site 596153006967 putative Zn2+ binding site [ion binding]; other site 596153006968 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 596153006969 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 596153006970 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153006971 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153006972 Transcriptional regulators [Transcription]; Region: PurR; COG1609 596153006973 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 596153006974 DNA binding site [nucleotide binding] 596153006975 domain linker motif; other site 596153006976 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 596153006977 putative dimerization interface [polypeptide binding]; other site 596153006978 putative ligand binding site [chemical binding]; other site 596153006979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153006980 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 596153006981 NAD(P) binding site [chemical binding]; other site 596153006982 active site 596153006983 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 596153006984 histidinol dehydrogenase; Region: hisD; TIGR00069 596153006985 NAD binding site [chemical binding]; other site 596153006986 dimerization interface [polypeptide binding]; other site 596153006987 product binding site; other site 596153006988 substrate binding site [chemical binding]; other site 596153006989 zinc binding site [ion binding]; other site 596153006990 catalytic residues [active] 596153006991 Methyltransferase domain; Region: Methyltransf_23; pfam13489 596153006992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153006993 S-adenosylmethionine binding site [chemical binding]; other site 596153006994 DTW domain; Region: DTW; cl01221 596153006995 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 596153006996 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 596153006997 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 596153006998 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 596153006999 Sulfatase; Region: Sulfatase; pfam00884 596153007000 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 596153007001 active site 596153007002 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 596153007003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153007004 active site 596153007005 phosphorylation site [posttranslational modification] 596153007006 intermolecular recognition site; other site 596153007007 dimerization interface [polypeptide binding]; other site 596153007008 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 596153007009 DNA binding site [nucleotide binding] 596153007010 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 596153007011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153007012 ATP binding site [chemical binding]; other site 596153007013 Mg2+ binding site [ion binding]; other site 596153007014 G-X-G motif; other site 596153007015 enoyl-CoA hydratase; Provisional; Region: PRK06494 596153007016 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153007017 substrate binding site [chemical binding]; other site 596153007018 oxyanion hole (OAH) forming residues; other site 596153007019 trimer interface [polypeptide binding]; other site 596153007020 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153007021 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 596153007022 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 596153007023 NAD(P) binding site [chemical binding]; other site 596153007024 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153007025 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153007026 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153007027 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153007028 active site 596153007029 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153007030 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153007031 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 596153007032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 596153007033 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 596153007034 hydroxyglutarate oxidase; Provisional; Region: PRK11728 596153007035 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 596153007036 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 596153007037 zinc binding site [ion binding]; other site 596153007038 putative ligand binding site [chemical binding]; other site 596153007039 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 596153007040 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 596153007041 TM-ABC transporter signature motif; other site 596153007042 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 596153007043 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 596153007044 Walker A/P-loop; other site 596153007045 ATP binding site [chemical binding]; other site 596153007046 Q-loop/lid; other site 596153007047 ABC transporter signature motif; other site 596153007048 Walker B; other site 596153007049 D-loop; other site 596153007050 H-loop/switch region; other site 596153007051 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 596153007052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153007053 Walker A motif; other site 596153007054 ATP binding site [chemical binding]; other site 596153007055 Walker B motif; other site 596153007056 arginine finger; other site 596153007057 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 596153007058 PGAP1-like protein; Region: PGAP1; pfam07819 596153007059 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 596153007060 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 596153007061 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 596153007062 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 596153007063 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 596153007064 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 596153007065 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 596153007066 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 596153007067 E3 interaction surface; other site 596153007068 lipoyl attachment site [posttranslational modification]; other site 596153007069 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 596153007070 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 596153007071 alpha subunit interface [polypeptide binding]; other site 596153007072 TPP binding site [chemical binding]; other site 596153007073 heterodimer interface [polypeptide binding]; other site 596153007074 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 596153007075 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 596153007076 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 596153007077 tetramer interface [polypeptide binding]; other site 596153007078 TPP-binding site [chemical binding]; other site 596153007079 heterodimer interface [polypeptide binding]; other site 596153007080 phosphorylation loop region [posttranslational modification] 596153007081 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 596153007082 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 596153007083 putative DNA binding site [nucleotide binding]; other site 596153007084 putative Zn2+ binding site [ion binding]; other site 596153007085 AsnC family; Region: AsnC_trans_reg; pfam01037 596153007086 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 596153007087 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 596153007088 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 596153007089 DctM-like transporters; Region: DctM; pfam06808 596153007090 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 596153007091 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 596153007092 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 596153007093 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 596153007094 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 596153007095 lipoyl attachment site [posttranslational modification]; other site 596153007096 glycine dehydrogenase; Provisional; Region: PRK05367 596153007097 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 596153007098 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 596153007099 catalytic residue [active] 596153007100 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 596153007101 tetramer interface [polypeptide binding]; other site 596153007102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153007103 catalytic residue [active] 596153007104 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 596153007105 putative metal binding site [ion binding]; other site 596153007106 putative homodimer interface [polypeptide binding]; other site 596153007107 putative homotetramer interface [polypeptide binding]; other site 596153007108 putative homodimer-homodimer interface [polypeptide binding]; other site 596153007109 putative allosteric switch controlling residues; other site 596153007110 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 596153007111 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 596153007112 substrate binding site [chemical binding]; other site 596153007113 catalytic Zn binding site [ion binding]; other site 596153007114 NAD binding site [chemical binding]; other site 596153007115 structural Zn binding site [ion binding]; other site 596153007116 dimer interface [polypeptide binding]; other site 596153007117 S-formylglutathione hydrolase; Region: PLN02442 596153007118 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 596153007119 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153007120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153007121 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 596153007122 dimerization interface [polypeptide binding]; other site 596153007123 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 596153007124 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 596153007125 FeS/SAM binding site; other site 596153007126 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 596153007127 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 596153007128 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 596153007129 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 596153007130 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 596153007131 FMN binding site [chemical binding]; other site 596153007132 substrate binding site [chemical binding]; other site 596153007133 putative catalytic residue [active] 596153007134 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 596153007135 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 596153007136 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153007137 active site 596153007138 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 596153007139 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 596153007140 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 596153007141 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 596153007142 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 596153007143 Ligand binding site [chemical binding]; other site 596153007144 Electron transfer flavoprotein domain; Region: ETF; pfam01012 596153007145 enoyl-CoA hydratase; Validated; Region: PRK08139 596153007146 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153007147 substrate binding site [chemical binding]; other site 596153007148 oxyanion hole (OAH) forming residues; other site 596153007149 trimer interface [polypeptide binding]; other site 596153007150 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 596153007151 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 596153007152 putative active site [active] 596153007153 Zn binding site [ion binding]; other site 596153007154 MoxR-like ATPases [General function prediction only]; Region: COG0714 596153007155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153007156 Walker A motif; other site 596153007157 ATP binding site [chemical binding]; other site 596153007158 Walker B motif; other site 596153007159 arginine finger; other site 596153007160 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 596153007161 Protein of unknown function DUF58; Region: DUF58; pfam01882 596153007162 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 596153007163 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 596153007164 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 596153007165 Transglycosylase SLT domain; Region: SLT_2; pfam13406 596153007166 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 596153007167 N-acetyl-D-glucosamine binding site [chemical binding]; other site 596153007168 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 596153007169 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 596153007170 PYR/PP interface [polypeptide binding]; other site 596153007171 dimer interface [polypeptide binding]; other site 596153007172 TPP binding site [chemical binding]; other site 596153007173 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 596153007174 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 596153007175 TPP-binding site [chemical binding]; other site 596153007176 dimer interface [polypeptide binding]; other site 596153007177 DctM-like transporters; Region: DctM; pfam06808 596153007178 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 596153007179 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 596153007180 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 596153007181 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 596153007182 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 596153007183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153007184 NAD(P) binding site [chemical binding]; other site 596153007185 active site 596153007186 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 596153007187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153007188 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 596153007189 dimerization interface [polypeptide binding]; other site 596153007190 substrate binding pocket [chemical binding]; other site 596153007191 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 596153007192 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 596153007193 TPP-binding site [chemical binding]; other site 596153007194 dimer interface [polypeptide binding]; other site 596153007195 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 596153007196 PYR/PP interface [polypeptide binding]; other site 596153007197 dimer interface [polypeptide binding]; other site 596153007198 TPP binding site [chemical binding]; other site 596153007199 glycerate dehydrogenase; Provisional; Region: PRK06932 596153007200 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 596153007201 putative ligand binding site [chemical binding]; other site 596153007202 putative NAD binding site [chemical binding]; other site 596153007203 catalytic site [active] 596153007204 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 596153007205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153007206 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 596153007207 putative dimerization interface [polypeptide binding]; other site 596153007208 Predicted membrane protein [Function unknown]; Region: COG2855 596153007209 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153007210 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 596153007211 putative ligand binding site [chemical binding]; other site 596153007212 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 596153007213 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 596153007214 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 596153007215 FtsX-like permease family; Region: FtsX; pfam02687 596153007216 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 596153007217 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 596153007218 Walker A/P-loop; other site 596153007219 ATP binding site [chemical binding]; other site 596153007220 Q-loop/lid; other site 596153007221 ABC transporter signature motif; other site 596153007222 Walker B; other site 596153007223 D-loop; other site 596153007224 H-loop/switch region; other site 596153007225 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 596153007226 HlyD family secretion protein; Region: HlyD_3; pfam13437 596153007227 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 596153007228 UGMP family protein; Validated; Region: PRK09604 596153007229 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 596153007230 FOG: CBS domain [General function prediction only]; Region: COG0517 596153007231 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 596153007232 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 596153007233 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 596153007234 HlyD family secretion protein; Region: HlyD_3; pfam13437 596153007235 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 596153007236 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 596153007237 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 596153007238 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 596153007239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 596153007240 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 596153007241 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 596153007242 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 596153007243 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 596153007244 [2Fe-2S] cluster binding site [ion binding]; other site 596153007245 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 596153007246 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 596153007247 [4Fe-4S] binding site [ion binding]; other site 596153007248 molybdopterin cofactor binding site; other site 596153007249 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 596153007250 molybdopterin cofactor binding site; other site 596153007251 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 596153007252 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 596153007253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153007254 putative substrate translocation pore; other site 596153007255 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 596153007256 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 596153007257 glycosyl transferase family protein; Provisional; Region: PRK08136 596153007258 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 596153007259 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 596153007260 active site 596153007261 SAM binding site [chemical binding]; other site 596153007262 homodimer interface [polypeptide binding]; other site 596153007263 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 596153007264 HI0933-like protein; Region: HI0933_like; pfam03486 596153007265 NnrS protein; Region: NnrS; pfam05940 596153007266 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 596153007267 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153007268 acyl-CoA synthetase; Validated; Region: PRK06145 596153007269 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153007270 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 596153007271 acyl-activating enzyme (AAE) consensus motif; other site 596153007272 acyl-activating enzyme (AAE) consensus motif; other site 596153007273 putative AMP binding site [chemical binding]; other site 596153007274 putative active site [active] 596153007275 putative CoA binding site [chemical binding]; other site 596153007276 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153007277 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 596153007278 active site 596153007279 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153007280 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 596153007281 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 596153007282 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 596153007283 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 596153007284 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 596153007285 E3 interaction surface; other site 596153007286 lipoyl attachment site [posttranslational modification]; other site 596153007287 e3 binding domain; Region: E3_binding; pfam02817 596153007288 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 596153007289 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 596153007290 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153007291 substrate binding site [chemical binding]; other site 596153007292 oxyanion hole (OAH) forming residues; other site 596153007293 trimer interface [polypeptide binding]; other site 596153007294 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 596153007295 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 596153007296 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 596153007297 alpha subunit interface [polypeptide binding]; other site 596153007298 TPP binding site [chemical binding]; other site 596153007299 heterodimer interface [polypeptide binding]; other site 596153007300 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 596153007301 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 596153007302 tetramer interface [polypeptide binding]; other site 596153007303 TPP-binding site [chemical binding]; other site 596153007304 heterodimer interface [polypeptide binding]; other site 596153007305 phosphorylation loop region [posttranslational modification] 596153007306 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 596153007307 active site 596153007308 catalytic site [active] 596153007309 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 596153007310 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 596153007311 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 596153007312 DUF35 OB-fold domain; Region: DUF35; pfam01796 596153007313 thiolase; Provisional; Region: PRK06158 596153007314 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 596153007315 active site 596153007316 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153007317 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153007318 active site 596153007319 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 596153007320 CoA binding domain; Region: CoA_binding_2; pfam13380 596153007321 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 596153007322 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 596153007323 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 596153007324 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153007325 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153007326 Domain of unknown function DUF59; Region: DUF59; cl00941 596153007327 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 596153007328 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 596153007329 trimerization site [polypeptide binding]; other site 596153007330 active site 596153007331 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 596153007332 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 596153007333 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 596153007334 catalytic residue [active] 596153007335 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 596153007336 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 596153007337 FeS assembly ATPase SufC; Region: sufC; TIGR01978 596153007338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 596153007339 Walker A/P-loop; other site 596153007340 ATP binding site [chemical binding]; other site 596153007341 Q-loop/lid; other site 596153007342 ABC transporter signature motif; other site 596153007343 Walker B; other site 596153007344 D-loop; other site 596153007345 H-loop/switch region; other site 596153007346 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 596153007347 putative ABC transporter; Region: ycf24; CHL00085 596153007348 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 596153007349 Yqey-like protein; Region: YqeY; pfam09424 596153007350 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 596153007351 Zn2+ binding site [ion binding]; other site 596153007352 Mg2+ binding site [ion binding]; other site 596153007353 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 596153007354 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 596153007355 PAS domain; Region: PAS_9; pfam13426 596153007356 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153007357 putative active site [active] 596153007358 heme pocket [chemical binding]; other site 596153007359 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 596153007360 DNA binding residues [nucleotide binding] 596153007361 dimerization interface [polypeptide binding]; other site 596153007362 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 596153007363 N-acetylglutamate synthase; Validated; Region: PRK05279 596153007364 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 596153007365 putative feedback inhibition sensing region; other site 596153007366 putative nucleotide binding site [chemical binding]; other site 596153007367 putative substrate binding site [chemical binding]; other site 596153007368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 596153007369 Coenzyme A binding pocket [chemical binding]; other site 596153007370 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 596153007371 homotrimer interaction site [polypeptide binding]; other site 596153007372 putative active site [active] 596153007373 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 596153007374 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 596153007375 hydroxyglutarate oxidase; Provisional; Region: PRK11728 596153007376 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 596153007377 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 596153007378 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 596153007379 ligand binding site [chemical binding]; other site 596153007380 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 596153007381 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 596153007382 TM-ABC transporter signature motif; other site 596153007383 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 596153007384 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 596153007385 TM-ABC transporter signature motif; other site 596153007386 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 596153007387 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 596153007388 Walker A/P-loop; other site 596153007389 ATP binding site [chemical binding]; other site 596153007390 Q-loop/lid; other site 596153007391 ABC transporter signature motif; other site 596153007392 Walker B; other site 596153007393 D-loop; other site 596153007394 H-loop/switch region; other site 596153007395 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 596153007396 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 596153007397 Walker A/P-loop; other site 596153007398 ATP binding site [chemical binding]; other site 596153007399 Q-loop/lid; other site 596153007400 ABC transporter signature motif; other site 596153007401 Walker B; other site 596153007402 D-loop; other site 596153007403 H-loop/switch region; other site 596153007404 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 596153007405 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 596153007406 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 596153007407 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 596153007408 dimer interface [polypeptide binding]; other site 596153007409 active site 596153007410 catalytic residue [active] 596153007411 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 596153007412 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 596153007413 dimer interface [polypeptide binding]; other site 596153007414 PYR/PP interface [polypeptide binding]; other site 596153007415 TPP binding site [chemical binding]; other site 596153007416 substrate binding site [chemical binding]; other site 596153007417 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 596153007418 TPP-binding site [chemical binding]; other site 596153007419 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 596153007420 Transcriptional regulators [Transcription]; Region: FadR; COG2186 596153007421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153007422 DNA-binding site [nucleotide binding]; DNA binding site 596153007423 FCD domain; Region: FCD; pfam07729 596153007424 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 596153007425 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 596153007426 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 596153007427 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 596153007428 Zn2+ binding site [ion binding]; other site 596153007429 Mg2+ binding site [ion binding]; other site 596153007430 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 596153007431 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 596153007432 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 596153007433 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 596153007434 Walker A/P-loop; other site 596153007435 ATP binding site [chemical binding]; other site 596153007436 Q-loop/lid; other site 596153007437 ABC transporter signature motif; other site 596153007438 Walker B; other site 596153007439 D-loop; other site 596153007440 H-loop/switch region; other site 596153007441 TOBE-like domain; Region: TOBE_3; pfam12857 596153007442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153007443 dimer interface [polypeptide binding]; other site 596153007444 conserved gate region; other site 596153007445 putative PBP binding loops; other site 596153007446 ABC-ATPase subunit interface; other site 596153007447 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 596153007448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153007449 dimer interface [polypeptide binding]; other site 596153007450 conserved gate region; other site 596153007451 putative PBP binding loops; other site 596153007452 ABC-ATPase subunit interface; other site 596153007453 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 596153007454 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 596153007455 Serine hydrolase; Region: Ser_hydrolase; pfam06821 596153007456 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 596153007457 LysR family transcriptional regulator; Provisional; Region: PRK14997 596153007458 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 596153007459 putative effector binding pocket; other site 596153007460 putative dimerization interface [polypeptide binding]; other site 596153007461 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 596153007462 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 596153007463 Predicted flavoprotein [General function prediction only]; Region: COG0431 596153007464 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 596153007465 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 596153007466 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 596153007467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153007468 dimer interface [polypeptide binding]; other site 596153007469 conserved gate region; other site 596153007470 ABC-ATPase subunit interface; other site 596153007471 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 596153007472 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 596153007473 Walker A/P-loop; other site 596153007474 ATP binding site [chemical binding]; other site 596153007475 Q-loop/lid; other site 596153007476 ABC transporter signature motif; other site 596153007477 Walker B; other site 596153007478 D-loop; other site 596153007479 H-loop/switch region; other site 596153007480 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 596153007481 MAPEG family; Region: MAPEG; cl09190 596153007482 recombination protein RecR; Reviewed; Region: recR; PRK00076 596153007483 RecR protein; Region: RecR; pfam02132 596153007484 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 596153007485 putative active site [active] 596153007486 putative metal-binding site [ion binding]; other site 596153007487 tetramer interface [polypeptide binding]; other site 596153007488 hypothetical protein; Validated; Region: PRK00153 596153007489 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 596153007490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153007491 Walker A motif; other site 596153007492 ATP binding site [chemical binding]; other site 596153007493 Walker B motif; other site 596153007494 arginine finger; other site 596153007495 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 596153007496 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 596153007497 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 596153007498 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 596153007499 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 596153007500 putative molybdenum utilization protein ModD; Region: modD; TIGR01334 596153007501 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 596153007502 active site 596153007503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 596153007504 putative PBP binding loops; other site 596153007505 ABC-ATPase subunit interface; other site 596153007506 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 596153007507 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 596153007508 Transposase domain (DUF772); Region: DUF772; pfam05598 596153007509 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 596153007510 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 596153007511 Methyltransferase domain; Region: Methyltransf_18; pfam12847 596153007512 S-adenosylmethionine binding site [chemical binding]; other site 596153007513 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 596153007514 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 596153007515 Walker A/P-loop; other site 596153007516 ATP binding site [chemical binding]; other site 596153007517 Q-loop/lid; other site 596153007518 ABC transporter signature motif; other site 596153007519 Walker B; other site 596153007520 D-loop; other site 596153007521 H-loop/switch region; other site 596153007522 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 596153007523 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 596153007524 putative PBP binding regions; other site 596153007525 ABC-ATPase subunit interface; other site 596153007526 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 596153007527 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 596153007528 intersubunit interface [polypeptide binding]; other site 596153007529 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 596153007530 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 596153007531 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 596153007532 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 596153007533 N-terminal plug; other site 596153007534 ligand-binding site [chemical binding]; other site 596153007535 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 596153007536 Pirin-related protein [General function prediction only]; Region: COG1741 596153007537 Pirin; Region: Pirin; pfam02678 596153007538 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 596153007539 Pirin-related protein [General function prediction only]; Region: COG1741 596153007540 Pirin; Region: Pirin; pfam02678 596153007541 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 596153007542 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 596153007543 AAA domain; Region: AAA_30; pfam13604 596153007544 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 596153007545 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 596153007546 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 596153007547 catalytic residues [active] 596153007548 transcription termination factor Rho; Provisional; Region: rho; PRK09376 596153007549 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 596153007550 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 596153007551 RNA binding site [nucleotide binding]; other site 596153007552 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 596153007553 multimer interface [polypeptide binding]; other site 596153007554 Walker A motif; other site 596153007555 ATP binding site [chemical binding]; other site 596153007556 Walker B motif; other site 596153007557 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 596153007558 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 596153007559 putative efflux protein, MATE family; Region: matE; TIGR00797 596153007560 cation binding site [ion binding]; other site 596153007561 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 596153007562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153007563 putative active site [active] 596153007564 heme pocket [chemical binding]; other site 596153007565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153007566 dimer interface [polypeptide binding]; other site 596153007567 phosphorylation site [posttranslational modification] 596153007568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153007569 ATP binding site [chemical binding]; other site 596153007570 Mg2+ binding site [ion binding]; other site 596153007571 G-X-G motif; other site 596153007572 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 596153007573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153007574 active site 596153007575 phosphorylation site [posttranslational modification] 596153007576 intermolecular recognition site; other site 596153007577 dimerization interface [polypeptide binding]; other site 596153007578 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 596153007579 DNA binding site [nucleotide binding] 596153007580 transcriptional regulator PhoU; Provisional; Region: PRK11115 596153007581 PhoU domain; Region: PhoU; pfam01895 596153007582 PhoU domain; Region: PhoU; pfam01895 596153007583 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 596153007584 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 596153007585 Walker A/P-loop; other site 596153007586 ATP binding site [chemical binding]; other site 596153007587 Q-loop/lid; other site 596153007588 ABC transporter signature motif; other site 596153007589 Walker B; other site 596153007590 D-loop; other site 596153007591 H-loop/switch region; other site 596153007592 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 596153007593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153007594 dimer interface [polypeptide binding]; other site 596153007595 conserved gate region; other site 596153007596 putative PBP binding loops; other site 596153007597 ABC-ATPase subunit interface; other site 596153007598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153007599 dimer interface [polypeptide binding]; other site 596153007600 conserved gate region; other site 596153007601 putative PBP binding loops; other site 596153007602 ABC-ATPase subunit interface; other site 596153007603 PBP superfamily domain; Region: PBP_like_2; cl17296 596153007604 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 596153007605 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 596153007606 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 596153007607 catalytic core [active] 596153007608 polyphosphate kinase; Provisional; Region: PRK05443 596153007609 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 596153007610 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 596153007611 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 596153007612 putative domain interface [polypeptide binding]; other site 596153007613 putative active site [active] 596153007614 catalytic site [active] 596153007615 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 596153007616 putative active site [active] 596153007617 catalytic site [active] 596153007618 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 596153007619 PAS domain S-box; Region: sensory_box; TIGR00229 596153007620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153007621 putative active site [active] 596153007622 heme pocket [chemical binding]; other site 596153007623 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153007624 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153007625 metal binding site [ion binding]; metal-binding site 596153007626 active site 596153007627 I-site; other site 596153007628 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 596153007629 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 596153007630 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 596153007631 active site 596153007632 substrate binding site [chemical binding]; other site 596153007633 metal binding site [ion binding]; metal-binding site 596153007634 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 596153007635 dihydropteroate synthase; Region: DHPS; TIGR01496 596153007636 substrate binding pocket [chemical binding]; other site 596153007637 dimer interface [polypeptide binding]; other site 596153007638 inhibitor binding site; inhibition site 596153007639 FtsH Extracellular; Region: FtsH_ext; pfam06480 596153007640 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 596153007641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153007642 Walker A motif; other site 596153007643 ATP binding site [chemical binding]; other site 596153007644 Walker B motif; other site 596153007645 arginine finger; other site 596153007646 Peptidase family M41; Region: Peptidase_M41; pfam01434 596153007647 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 596153007648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153007649 S-adenosylmethionine binding site [chemical binding]; other site 596153007650 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 596153007651 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 596153007652 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 596153007653 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 596153007654 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 596153007655 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 596153007656 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 596153007657 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 596153007658 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 596153007659 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 596153007660 ATP-grasp domain; Region: ATP-grasp_4; cl17255 596153007661 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 596153007662 IMP binding site; other site 596153007663 dimer interface [polypeptide binding]; other site 596153007664 interdomain contacts; other site 596153007665 partial ornithine binding site; other site 596153007666 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 596153007667 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 596153007668 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 596153007669 catalytic site [active] 596153007670 subunit interface [polypeptide binding]; other site 596153007671 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 596153007672 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 596153007673 DNA binding residues [nucleotide binding] 596153007674 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 596153007675 IHF - DNA interface [nucleotide binding]; other site 596153007676 IHF dimer interface [polypeptide binding]; other site 596153007677 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 596153007678 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 596153007679 putative tRNA-binding site [nucleotide binding]; other site 596153007680 B3/4 domain; Region: B3_4; pfam03483 596153007681 tRNA synthetase B5 domain; Region: B5; smart00874 596153007682 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 596153007683 dimer interface [polypeptide binding]; other site 596153007684 motif 1; other site 596153007685 motif 3; other site 596153007686 motif 2; other site 596153007687 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 596153007688 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 596153007689 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 596153007690 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 596153007691 dimer interface [polypeptide binding]; other site 596153007692 motif 1; other site 596153007693 active site 596153007694 motif 2; other site 596153007695 motif 3; other site 596153007696 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 596153007697 23S rRNA binding site [nucleotide binding]; other site 596153007698 L21 binding site [polypeptide binding]; other site 596153007699 L13 binding site [polypeptide binding]; other site 596153007700 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 596153007701 translation initiation factor IF-3; Region: infC; TIGR00168 596153007702 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 596153007703 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 596153007704 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 596153007705 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 596153007706 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 596153007707 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 596153007708 active site 596153007709 dimer interface [polypeptide binding]; other site 596153007710 motif 1; other site 596153007711 motif 2; other site 596153007712 motif 3; other site 596153007713 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 596153007714 anticodon binding site; other site 596153007715 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 596153007716 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 596153007717 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 596153007718 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 596153007719 isocitrate lyase; Provisional; Region: PRK15063 596153007720 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 596153007721 tetramer interface [polypeptide binding]; other site 596153007722 active site 596153007723 Mg2+/Mn2+ binding site [ion binding]; other site 596153007724 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 596153007725 EamA-like transporter family; Region: EamA; pfam00892 596153007726 EamA-like transporter family; Region: EamA; pfam00892 596153007727 SWIB/MDM2 domain; Region: SWIB; pfam02201 596153007728 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 596153007729 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 596153007730 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 596153007731 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 596153007732 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 596153007733 TolR protein; Region: tolR; TIGR02801 596153007734 Hemin uptake protein hemP; Region: hemP; pfam10636 596153007735 Domain of unknown function (DUF336); Region: DUF336; cl01249 596153007736 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 596153007737 YccA-like proteins; Region: YccA_like; cd10433 596153007738 MarR family; Region: MarR_2; cl17246 596153007739 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 596153007740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153007741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153007742 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 596153007743 Chromate transporter; Region: Chromate_transp; pfam02417 596153007744 Chromate transporter; Region: Chromate_transp; pfam02417 596153007745 NAD-dependent deacetylase; Provisional; Region: PRK00481 596153007746 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 596153007747 NAD+ binding site [chemical binding]; other site 596153007748 substrate binding site [chemical binding]; other site 596153007749 Zn binding site [ion binding]; other site 596153007750 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 596153007751 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 596153007752 WHG domain; Region: WHG; pfam13305 596153007753 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 596153007754 Uncharacterized conserved protein [Function unknown]; Region: COG3791 596153007755 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 596153007756 dimer interface [polypeptide binding]; other site 596153007757 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 596153007758 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 596153007759 putative hydrophobic ligand binding site [chemical binding]; other site 596153007760 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 596153007761 dimer interface [polypeptide binding]; other site 596153007762 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 596153007763 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 596153007764 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 596153007765 putative hydrophobic ligand binding site [chemical binding]; other site 596153007766 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 596153007767 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 596153007768 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 596153007769 serine/threonine transporter SstT; Provisional; Region: PRK13628 596153007770 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 596153007771 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 596153007772 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 596153007773 Walker A/P-loop; other site 596153007774 ATP binding site [chemical binding]; other site 596153007775 Q-loop/lid; other site 596153007776 ABC transporter signature motif; other site 596153007777 Walker B; other site 596153007778 D-loop; other site 596153007779 H-loop/switch region; other site 596153007780 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 596153007781 active site 596153007782 catalytic triad [active] 596153007783 oxyanion hole [active] 596153007784 switch loop; other site 596153007785 Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955 596153007786 cystathionine beta-lyase; Provisional; Region: PRK07050 596153007787 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 596153007788 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 596153007789 catalytic residue [active] 596153007790 BON domain; Region: BON; pfam04972 596153007791 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 596153007792 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 596153007793 Sulfate transporter family; Region: Sulfate_transp; pfam00916 596153007794 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 596153007795 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153007796 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153007797 metal binding site [ion binding]; metal-binding site 596153007798 active site 596153007799 I-site; other site 596153007800 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 596153007801 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 596153007802 P-loop; other site 596153007803 ADP binding residues [chemical binding]; other site 596153007804 Switch I; other site 596153007805 Switch II; other site 596153007806 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 596153007807 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153007808 acyl-activating enzyme (AAE) consensus motif; other site 596153007809 AMP binding site [chemical binding]; other site 596153007810 active site 596153007811 CoA binding site [chemical binding]; other site 596153007812 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 596153007813 Isochorismatase family; Region: Isochorismatase; pfam00857 596153007814 catalytic triad [active] 596153007815 dimer interface [polypeptide binding]; other site 596153007816 conserved cis-peptide bond; other site 596153007817 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 596153007818 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 596153007819 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 596153007820 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153007821 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153007822 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153007823 dimerization interface [polypeptide binding]; other site 596153007824 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 596153007825 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 596153007826 tetrameric interface [polypeptide binding]; other site 596153007827 NAD binding site [chemical binding]; other site 596153007828 catalytic residues [active] 596153007829 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 596153007830 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153007831 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153007832 active site 596153007833 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 596153007834 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 596153007835 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 596153007836 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 596153007837 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 596153007838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153007839 catalytic residue [active] 596153007840 Protein with unknown function (DUF469); Region: DUF469; pfam04320 596153007841 galactarate dehydratase; Region: galactar-dH20; TIGR03248 596153007842 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 596153007843 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 596153007844 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153007845 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 596153007846 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 596153007847 active site 596153007848 tetramer interface [polypeptide binding]; other site 596153007849 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 596153007850 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153007851 DNA-binding site [nucleotide binding]; DNA binding site 596153007852 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 596153007853 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153007854 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 596153007855 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 596153007856 putative active site [active] 596153007857 catalytic residue [active] 596153007858 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153007859 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 596153007860 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 596153007861 putative ligand binding site [chemical binding]; other site 596153007862 NAD binding site [chemical binding]; other site 596153007863 catalytic site [active] 596153007864 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 596153007865 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 596153007866 active site 596153007867 tetramer interface [polypeptide binding]; other site 596153007868 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 596153007869 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 596153007870 NAD(P) binding site [chemical binding]; other site 596153007871 catalytic residues [active] 596153007872 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 596153007873 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 596153007874 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 596153007875 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 596153007876 Pirin-related protein [General function prediction only]; Region: COG1741 596153007877 Pirin; Region: Pirin; pfam02678 596153007878 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153007879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153007880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153007881 dimerization interface [polypeptide binding]; other site 596153007882 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 596153007883 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 596153007884 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 596153007885 active site 596153007886 HIGH motif; other site 596153007887 nucleotide binding site [chemical binding]; other site 596153007888 active site 596153007889 KMSKS motif; other site 596153007890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153007891 S-adenosylmethionine binding site [chemical binding]; other site 596153007892 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153007893 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153007894 metal binding site [ion binding]; metal-binding site 596153007895 active site 596153007896 I-site; other site 596153007897 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 596153007898 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 596153007899 motif 1; other site 596153007900 active site 596153007901 motif 2; other site 596153007902 motif 3; other site 596153007903 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 596153007904 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 596153007905 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 596153007906 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 596153007907 inhibitor site; inhibition site 596153007908 active site 596153007909 dimer interface [polypeptide binding]; other site 596153007910 catalytic residue [active] 596153007911 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 596153007912 DctM-like transporters; Region: DctM; pfam06808 596153007913 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 596153007914 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 596153007915 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 596153007916 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 596153007917 Transcriptional regulators [Transcription]; Region: GntR; COG1802 596153007918 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153007919 DNA-binding site [nucleotide binding]; DNA binding site 596153007920 FCD domain; Region: FCD; pfam07729 596153007921 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 596153007922 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 596153007923 probable active site [active] 596153007924 CoA binding domain; Region: CoA_binding_2; pfam13380 596153007925 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 596153007926 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 596153007927 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 596153007928 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 596153007929 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 596153007930 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 596153007931 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 596153007932 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 596153007933 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 596153007934 active site 596153007935 substrate binding site [chemical binding]; other site 596153007936 metal binding site [ion binding]; metal-binding site 596153007937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153007938 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153007939 KduI/IolB family; Region: KduI; cl01508 596153007940 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 596153007941 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 596153007942 substrate binding site [chemical binding]; other site 596153007943 ATP binding site [chemical binding]; other site 596153007944 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 596153007945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 596153007946 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 596153007947 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 596153007948 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 596153007949 putative active site [active] 596153007950 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 596153007951 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 596153007952 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 596153007953 AlkA N-terminal domain; Region: AlkA_N; pfam06029 596153007954 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 596153007955 minor groove reading motif; other site 596153007956 helix-hairpin-helix signature motif; other site 596153007957 active site 596153007958 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 596153007959 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 596153007960 DNA binding site [nucleotide binding] 596153007961 active site 596153007962 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 596153007963 EamA-like transporter family; Region: EamA; pfam00892 596153007964 cyclase homology domain; Region: CHD; cd07302 596153007965 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 596153007966 nucleotidyl binding site; other site 596153007967 metal binding site [ion binding]; metal-binding site 596153007968 dimer interface [polypeptide binding]; other site 596153007969 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 596153007970 phosphopeptide binding site; other site 596153007971 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 596153007972 dimer interface [polypeptide binding]; other site 596153007973 catalytic triad [active] 596153007974 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 596153007975 nucleoside/Zn binding site; other site 596153007976 dimer interface [polypeptide binding]; other site 596153007977 catalytic motif [active] 596153007978 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 596153007979 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 596153007980 Peptidase family U32; Region: Peptidase_U32; pfam01136 596153007981 Collagenase; Region: DUF3656; pfam12392 596153007982 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 596153007983 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 596153007984 homodimer interface [polypeptide binding]; other site 596153007985 substrate-cofactor binding pocket; other site 596153007986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153007987 catalytic residue [active] 596153007988 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 596153007989 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 596153007990 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 596153007991 Methyltransferase domain; Region: Methyltransf_26; pfam13659 596153007992 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 596153007993 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 596153007994 Protein of unknown function (DUF808); Region: DUF808; pfam05661 596153007995 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 596153007996 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 596153007997 dimerization interface [polypeptide binding]; other site 596153007998 ATP binding site [chemical binding]; other site 596153007999 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 596153008000 dimerization interface [polypeptide binding]; other site 596153008001 ATP binding site [chemical binding]; other site 596153008002 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 596153008003 putative active site [active] 596153008004 catalytic triad [active] 596153008005 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 596153008006 active site 596153008007 PII uridylyl-transferase; Provisional; Region: PRK03059 596153008008 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 596153008009 metal binding triad; other site 596153008010 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 596153008011 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 596153008012 Zn2+ binding site [ion binding]; other site 596153008013 Mg2+ binding site [ion binding]; other site 596153008014 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 596153008015 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 596153008016 xanthine permease; Region: pbuX; TIGR03173 596153008017 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 596153008018 active site 596153008019 catalytic residues [active] 596153008020 metal binding site [ion binding]; metal-binding site 596153008021 Protein of unknown function (DUF454); Region: DUF454; cl01063 596153008022 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 596153008023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 596153008024 AAA domain; Region: AAA_33; pfam13671 596153008025 isocitrate dehydrogenase; Validated; Region: PRK07362 596153008026 isocitrate dehydrogenase; Reviewed; Region: PRK07006 596153008027 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 596153008028 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 596153008029 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 596153008030 superoxide dismutase; Provisional; Region: PRK10543 596153008031 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 596153008032 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 596153008033 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 596153008034 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 596153008035 generic binding surface II; other site 596153008036 generic binding surface I; other site 596153008037 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 596153008038 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 596153008039 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 596153008040 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 596153008041 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 596153008042 Uncharacterized conserved protein [Function unknown]; Region: COG2835 596153008043 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 596153008044 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 596153008045 Ligand binding site; other site 596153008046 oligomer interface; other site 596153008047 adenylate kinase; Reviewed; Region: adk; PRK00279 596153008048 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 596153008049 AMP-binding site [chemical binding]; other site 596153008050 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 596153008051 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 596153008052 active site 596153008053 homotetramer interface [polypeptide binding]; other site 596153008054 homodimer interface [polypeptide binding]; other site 596153008055 LexA repressor; Validated; Region: PRK00215 596153008056 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 596153008057 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 596153008058 Catalytic site [active] 596153008059 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 596153008060 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 596153008061 ATP binding site [chemical binding]; other site 596153008062 putative Mg++ binding site [ion binding]; other site 596153008063 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 596153008064 nucleotide binding region [chemical binding]; other site 596153008065 ATP-binding site [chemical binding]; other site 596153008066 Helicase associated domain (HA2); Region: HA2; pfam04408 596153008067 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 596153008068 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 596153008069 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 596153008070 active site 596153008071 acyl-CoA synthetase; Validated; Region: PRK07638 596153008072 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153008073 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 596153008074 acyl-activating enzyme (AAE) consensus motif; other site 596153008075 acyl-activating enzyme (AAE) consensus motif; other site 596153008076 AMP binding site [chemical binding]; other site 596153008077 active site 596153008078 CoA binding site [chemical binding]; other site 596153008079 BioY family; Region: BioY; pfam02632 596153008080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 596153008081 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 596153008082 Walker A/P-loop; other site 596153008083 ATP binding site [chemical binding]; other site 596153008084 Q-loop/lid; other site 596153008085 ABC transporter signature motif; other site 596153008086 Walker B; other site 596153008087 D-loop; other site 596153008088 H-loop/switch region; other site 596153008089 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 596153008090 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 596153008091 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 596153008092 dimer interface [polypeptide binding]; other site 596153008093 active site 596153008094 metal binding site [ion binding]; metal-binding site 596153008095 glutathione binding site [chemical binding]; other site 596153008096 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 596153008097 Dynamin family; Region: Dynamin_N; pfam00350 596153008098 G1 box; other site 596153008099 GTP/Mg2+ binding site [chemical binding]; other site 596153008100 G2 box; other site 596153008101 Switch I region; other site 596153008102 G3 box; other site 596153008103 Switch II region; other site 596153008104 G4 box; other site 596153008105 G5 box; other site 596153008106 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 596153008107 GTP/Mg2+ binding site [chemical binding]; other site 596153008108 G1 box; other site 596153008109 G2 box; other site 596153008110 G3 box; other site 596153008111 Switch II region; other site 596153008112 G4 box; other site 596153008113 G5 box; other site 596153008114 benzoate transport; Region: 2A0115; TIGR00895 596153008115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153008116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153008117 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153008118 Muconolactone delta-isomerase; Region: MIase; cl01992 596153008119 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 596153008120 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 596153008121 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 596153008122 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 596153008123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153008124 NAD(P) binding site [chemical binding]; other site 596153008125 active site 596153008126 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 596153008127 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 596153008128 dimer interface [polypeptide binding]; other site 596153008129 active site 596153008130 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 596153008131 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 596153008132 octamer interface [polypeptide binding]; other site 596153008133 active site 596153008134 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 596153008135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153008136 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 596153008137 dimerizarion interface [polypeptide binding]; other site 596153008138 CrgA pocket; other site 596153008139 substrate binding pocket [chemical binding]; other site 596153008140 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 596153008141 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 596153008142 active site 596153008143 intersubunit interface [polypeptide binding]; other site 596153008144 catalytic residue [active] 596153008145 phosphogluconate dehydratase; Validated; Region: PRK09054 596153008146 6-phosphogluconate dehydratase; Region: edd; TIGR01196 596153008147 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 596153008148 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 596153008149 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 596153008150 DctM-like transporters; Region: DctM; pfam06808 596153008151 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 596153008152 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 596153008153 ATP-binding site [chemical binding]; other site 596153008154 Gluconate-6-phosphate binding site [chemical binding]; other site 596153008155 Transcriptional regulators [Transcription]; Region: PurR; COG1609 596153008156 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 596153008157 DNA binding site [nucleotide binding] 596153008158 domain linker motif; other site 596153008159 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 596153008160 putative ligand binding site [chemical binding]; other site 596153008161 putative dimerization interface [polypeptide binding]; other site 596153008162 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 596153008163 Clp amino terminal domain; Region: Clp_N; pfam02861 596153008164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153008165 Walker A motif; other site 596153008166 ATP binding site [chemical binding]; other site 596153008167 Walker B motif; other site 596153008168 arginine finger; other site 596153008169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153008170 Walker A motif; other site 596153008171 ATP binding site [chemical binding]; other site 596153008172 Walker B motif; other site 596153008173 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 596153008174 Uncharacterized conserved protein [Function unknown]; Region: COG2127 596153008175 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 596153008176 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 596153008177 putative active site [active] 596153008178 putative PHP Thumb interface [polypeptide binding]; other site 596153008179 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 596153008180 generic binding surface II; other site 596153008181 generic binding surface I; other site 596153008182 Outer membrane lipoprotein; Region: YfiO; pfam13525 596153008183 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 596153008184 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 596153008185 DEAD_2; Region: DEAD_2; pfam06733 596153008186 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 596153008187 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 596153008188 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 596153008189 active site 596153008190 Predicted ATPase [General function prediction only]; Region: COG1485 596153008191 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 596153008192 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 596153008193 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 596153008194 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 596153008195 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 596153008196 E3 interaction surface; other site 596153008197 lipoyl attachment site [posttranslational modification]; other site 596153008198 e3 binding domain; Region: E3_binding; pfam02817 596153008199 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 596153008200 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 596153008201 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 596153008202 TPP-binding site [chemical binding]; other site 596153008203 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 596153008204 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 596153008205 Domain of unknown function DUF20; Region: UPF0118; pfam01594 596153008206 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153008207 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 596153008208 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153008209 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153008210 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 596153008211 putative dimerization interface [polypeptide binding]; other site 596153008212 Universal stress protein family; Region: Usp; pfam00582 596153008213 Ligand Binding Site [chemical binding]; other site 596153008214 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 596153008215 Ligand Binding Site [chemical binding]; other site 596153008216 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 596153008217 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 596153008218 Walker A/P-loop; other site 596153008219 ATP binding site [chemical binding]; other site 596153008220 Q-loop/lid; other site 596153008221 ABC transporter signature motif; other site 596153008222 Walker B; other site 596153008223 D-loop; other site 596153008224 H-loop/switch region; other site 596153008225 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 596153008226 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 596153008227 Walker A/P-loop; other site 596153008228 ATP binding site [chemical binding]; other site 596153008229 Q-loop/lid; other site 596153008230 ABC transporter signature motif; other site 596153008231 Walker B; other site 596153008232 D-loop; other site 596153008233 H-loop/switch region; other site 596153008234 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 596153008235 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 596153008236 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 596153008237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153008238 dimer interface [polypeptide binding]; other site 596153008239 conserved gate region; other site 596153008240 putative PBP binding loops; other site 596153008241 ABC-ATPase subunit interface; other site 596153008242 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 596153008243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153008244 dimer interface [polypeptide binding]; other site 596153008245 conserved gate region; other site 596153008246 putative PBP binding loops; other site 596153008247 ABC-ATPase subunit interface; other site 596153008248 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 596153008249 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 596153008250 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 596153008251 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 596153008252 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 596153008253 NAD binding site [chemical binding]; other site 596153008254 homotetramer interface [polypeptide binding]; other site 596153008255 homodimer interface [polypeptide binding]; other site 596153008256 substrate binding site [chemical binding]; other site 596153008257 active site 596153008258 aromatic amino acid exporter; Provisional; Region: PRK11689 596153008259 EamA-like transporter family; Region: EamA; pfam00892 596153008260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 596153008261 DNA ligase; Provisional; Region: PRK09125 596153008262 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 596153008263 DNA binding site [nucleotide binding] 596153008264 active site 596153008265 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 596153008266 DNA binding site [nucleotide binding] 596153008267 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 596153008268 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 596153008269 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 596153008270 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 596153008271 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 596153008272 catalytic residue [active] 596153008273 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 596153008274 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 596153008275 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 596153008276 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 596153008277 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 596153008278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153008279 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 596153008280 dimerization interface [polypeptide binding]; other site 596153008281 substrate binding pocket [chemical binding]; other site 596153008282 thiamine pyrophosphate protein; Validated; Region: PRK08199 596153008283 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 596153008284 PYR/PP interface [polypeptide binding]; other site 596153008285 dimer interface [polypeptide binding]; other site 596153008286 TPP binding site [chemical binding]; other site 596153008287 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 596153008288 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 596153008289 TPP-binding site [chemical binding]; other site 596153008290 hypothetical protein; Provisional; Region: PRK02237 596153008291 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 596153008292 active site 596153008293 DNA binding site [nucleotide binding] 596153008294 Int/Topo IB signature motif; other site 596153008295 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 596153008296 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 596153008297 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 596153008298 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 596153008299 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 596153008300 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 596153008301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 596153008302 motif II; other site 596153008303 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 596153008304 RNA polymerase sigma factor, SigZ family; Region: SigZ; TIGR02959 596153008305 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 596153008306 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 596153008307 DNA binding residues [nucleotide binding] 596153008308 Predicted permeases [General function prediction only]; Region: COG0701 596153008309 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 596153008310 catalytic residues [active] 596153008311 OsmC-like protein; Region: OsmC; pfam02566 596153008312 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 596153008313 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 596153008314 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 596153008315 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 596153008316 putative active site [active] 596153008317 putative dimer interface [polypeptide binding]; other site 596153008318 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 596153008319 4Fe-4S binding domain; Region: Fer4; cl02805 596153008320 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 596153008321 FAD binding pocket [chemical binding]; other site 596153008322 conserved FAD binding motif [chemical binding]; other site 596153008323 phosphate binding motif [ion binding]; other site 596153008324 beta-alpha-beta structure motif; other site 596153008325 NAD binding pocket [chemical binding]; other site 596153008326 putative acyltransferase; Provisional; Region: PRK05790 596153008327 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 596153008328 dimer interface [polypeptide binding]; other site 596153008329 active site 596153008330 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 596153008331 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 596153008332 Predicted permease; Region: DUF318; cl17795 596153008333 Predicted permease; Region: DUF318; cl17795 596153008334 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 596153008335 Protein of unknown function (DUF3732); Region: DUF3732; pfam12532 596153008336 putative transposase OrfB; Reviewed; Region: PHA02517 596153008337 HTH-like domain; Region: HTH_21; pfam13276 596153008338 Integrase core domain; Region: rve; pfam00665 596153008339 Integrase core domain; Region: rve_3; cl15866 596153008340 Transposase; Region: HTH_Tnp_1; cl17663 596153008341 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153008342 DNA topoisomerase III; Provisional; Region: PRK07726 596153008343 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 596153008344 active site 596153008345 putative interdomain interaction site [polypeptide binding]; other site 596153008346 putative metal-binding site [ion binding]; other site 596153008347 putative nucleotide binding site [chemical binding]; other site 596153008348 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 596153008349 domain I; other site 596153008350 DNA binding groove [nucleotide binding] 596153008351 phosphate binding site [ion binding]; other site 596153008352 domain II; other site 596153008353 domain III; other site 596153008354 nucleotide binding site [chemical binding]; other site 596153008355 catalytic site [active] 596153008356 domain IV; other site 596153008357 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 596153008358 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 596153008359 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 596153008360 dimer interface [polypeptide binding]; other site 596153008361 ssDNA binding site [nucleotide binding]; other site 596153008362 tetramer (dimer of dimers) interface [polypeptide binding]; other site 596153008363 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 596153008364 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 596153008365 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 596153008366 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 596153008367 ParB-like nuclease domain; Region: ParBc; pfam02195 596153008368 YcfA-like protein; Region: YcfA; cl00752 596153008369 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 596153008370 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 596153008371 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 596153008372 Magnesium ion binding site [ion binding]; other site 596153008373 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 596153008374 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153008375 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153008376 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 596153008377 dimerization interface [polypeptide binding]; other site 596153008378 substrate binding pocket [chemical binding]; other site 596153008379 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 596153008380 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 596153008381 HlyD family secretion protein; Region: HlyD_3; pfam13437 596153008382 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 596153008383 Outer membrane efflux protein; Region: OEP; pfam02321 596153008384 Outer membrane efflux protein; Region: OEP; pfam02321 596153008385 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 596153008386 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 596153008387 Soluble P-type ATPase [General function prediction only]; Region: COG4087 596153008388 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 596153008389 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 596153008390 Cytochrome c; Region: Cytochrom_C; pfam00034 596153008391 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 596153008392 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 596153008393 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 596153008394 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 596153008395 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 596153008396 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 596153008397 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 596153008398 Multicopper oxidase; Region: Cu-oxidase; pfam00394 596153008399 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 596153008400 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 596153008401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153008402 active site 596153008403 phosphorylation site [posttranslational modification] 596153008404 intermolecular recognition site; other site 596153008405 dimerization interface [polypeptide binding]; other site 596153008406 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 596153008407 DNA binding site [nucleotide binding] 596153008408 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 596153008409 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 596153008410 dimerization interface [polypeptide binding]; other site 596153008411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153008412 dimer interface [polypeptide binding]; other site 596153008413 phosphorylation site [posttranslational modification] 596153008414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153008415 ATP binding site [chemical binding]; other site 596153008416 Mg2+ binding site [ion binding]; other site 596153008417 G-X-G motif; other site 596153008418 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 596153008419 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 596153008420 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 596153008421 Multicopper oxidase; Region: Cu-oxidase; pfam00394 596153008422 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 596153008423 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153008424 Helix-turn-helix domain; Region: HTH_28; pfam13518 596153008425 putative transposase OrfB; Reviewed; Region: PHA02517 596153008426 HTH-like domain; Region: HTH_21; pfam13276 596153008427 Integrase core domain; Region: rve; pfam00665 596153008428 Integrase core domain; Region: rve_3; pfam13683 596153008429 EamA-like transporter family; Region: EamA; pfam00892 596153008430 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 596153008431 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 596153008432 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 596153008433 Soluble P-type ATPase [General function prediction only]; Region: COG4087 596153008434 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 596153008435 putative metal binding site [ion binding]; other site 596153008436 putative homodimer interface [polypeptide binding]; other site 596153008437 putative homotetramer interface [polypeptide binding]; other site 596153008438 putative homodimer-homodimer interface [polypeptide binding]; other site 596153008439 putative allosteric switch controlling residues; other site 596153008440 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153008441 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153008442 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 596153008443 dimerization interface [polypeptide binding]; other site 596153008444 substrate binding pocket [chemical binding]; other site 596153008445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 596153008446 non-specific DNA binding site [nucleotide binding]; other site 596153008447 salt bridge; other site 596153008448 sequence-specific DNA binding site [nucleotide binding]; other site 596153008449 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 596153008450 IHF - DNA interface [nucleotide binding]; other site 596153008451 IHF dimer interface [polypeptide binding]; other site 596153008452 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 596153008453 tellurium resistance terB-like protein; Region: terB_like; cd07177 596153008454 metal binding site [ion binding]; metal-binding site 596153008455 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 596153008456 transcriptional activator TtdR; Provisional; Region: PRK09801 596153008457 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153008458 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 596153008459 putative effector binding pocket; other site 596153008460 putative dimerization interface [polypeptide binding]; other site 596153008461 tartrate dehydrogenase; Region: TTC; TIGR02089 596153008462 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 596153008463 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 596153008464 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 596153008465 active site 596153008466 nucleophile elbow; other site 596153008467 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 596153008468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153008469 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153008470 dimerization interface [polypeptide binding]; other site 596153008471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153008472 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 596153008473 galactarate dehydratase; Region: galactar-dH20; TIGR03248 596153008474 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 596153008475 succinic semialdehyde dehydrogenase; Region: PLN02278 596153008476 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 596153008477 tetramerization interface [polypeptide binding]; other site 596153008478 NAD(P) binding site [chemical binding]; other site 596153008479 catalytic residues [active] 596153008480 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 596153008481 Methyltransferase domain; Region: Methyltransf_23; pfam13489 596153008482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153008483 S-adenosylmethionine binding site [chemical binding]; other site 596153008484 glutamate racemase; Provisional; Region: PRK00865 596153008485 N-formylglutamate amidohydrolase; Region: FGase; cl01522 596153008486 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 596153008487 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 596153008488 active site 596153008489 imidazolonepropionase; Validated; Region: PRK09356 596153008490 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 596153008491 active site 596153008492 HutD; Region: HutD; pfam05962 596153008493 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 596153008494 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 596153008495 Walker A/P-loop; other site 596153008496 ATP binding site [chemical binding]; other site 596153008497 Q-loop/lid; other site 596153008498 ABC transporter signature motif; other site 596153008499 Walker B; other site 596153008500 D-loop; other site 596153008501 H-loop/switch region; other site 596153008502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 596153008503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153008504 putative PBP binding loops; other site 596153008505 dimer interface [polypeptide binding]; other site 596153008506 ABC-ATPase subunit interface; other site 596153008507 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 596153008508 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 596153008509 substrate binding pocket [chemical binding]; other site 596153008510 membrane-bound complex binding site; other site 596153008511 hinge residues; other site 596153008512 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153008513 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 596153008514 putative DNA binding site [nucleotide binding]; other site 596153008515 putative Zn2+ binding site [ion binding]; other site 596153008516 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153008517 urocanate hydratase; Provisional; Region: PRK05414 596153008518 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 596153008519 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 596153008520 Na binding site [ion binding]; other site 596153008521 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 596153008522 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153008523 DNA-binding site [nucleotide binding]; DNA binding site 596153008524 UTRA domain; Region: UTRA; pfam07702 596153008525 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 596153008526 active sites [active] 596153008527 tetramer interface [polypeptide binding]; other site 596153008528 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 596153008529 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153008530 DNA-binding site [nucleotide binding]; DNA binding site 596153008531 UTRA domain; Region: UTRA; pfam07702 596153008532 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 596153008533 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 596153008534 Walker A/P-loop; other site 596153008535 ATP binding site [chemical binding]; other site 596153008536 Q-loop/lid; other site 596153008537 ABC transporter signature motif; other site 596153008538 Walker B; other site 596153008539 D-loop; other site 596153008540 H-loop/switch region; other site 596153008541 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 596153008542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153008543 dimer interface [polypeptide binding]; other site 596153008544 conserved gate region; other site 596153008545 putative PBP binding loops; other site 596153008546 ABC-ATPase subunit interface; other site 596153008547 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 596153008548 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 596153008549 substrate binding pocket [chemical binding]; other site 596153008550 membrane-bound complex binding site; other site 596153008551 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153008552 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153008553 active site 596153008554 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153008555 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153008556 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153008557 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153008558 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 596153008559 putative substrate binding pocket [chemical binding]; other site 596153008560 dimerization interface [polypeptide binding]; other site 596153008561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153008562 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153008563 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 596153008564 active site 596153008565 catalytic residues [active] 596153008566 metal binding site [ion binding]; metal-binding site 596153008567 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153008568 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153008569 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153008570 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153008571 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 596153008572 putative dimerization interface [polypeptide binding]; other site 596153008573 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 596153008574 elongation factor P; Validated; Region: PRK00529 596153008575 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 596153008576 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 596153008577 RNA binding site [nucleotide binding]; other site 596153008578 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 596153008579 RNA binding site [nucleotide binding]; other site 596153008580 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 596153008581 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 596153008582 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 596153008583 phosphoenolpyruvate synthase; Validated; Region: PRK06464 596153008584 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 596153008585 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 596153008586 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 596153008587 PEP synthetase regulatory protein; Provisional; Region: PRK05339 596153008588 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 596153008589 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 596153008590 HlyD family secretion protein; Region: HlyD_3; pfam13437 596153008591 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 596153008592 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 596153008593 tetramer interface [polypeptide binding]; other site 596153008594 heme binding pocket [chemical binding]; other site 596153008595 NADPH binding site [chemical binding]; other site 596153008596 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 596153008597 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 596153008598 catalytic residue [active] 596153008599 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 596153008600 catalytic residues [active] 596153008601 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 596153008602 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 596153008603 peroxiredoxin; Region: AhpC; TIGR03137 596153008604 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 596153008605 dimer interface [polypeptide binding]; other site 596153008606 decamer (pentamer of dimers) interface [polypeptide binding]; other site 596153008607 catalytic triad [active] 596153008608 peroxidatic and resolving cysteines [active] 596153008609 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 596153008610 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 596153008611 heme binding site [chemical binding]; other site 596153008612 ferroxidase pore; other site 596153008613 ferroxidase diiron center [ion binding]; other site 596153008614 Flagellar transcriptional activator (FlhD); Region: FlhD; pfam05247 596153008615 transcriptional activator FlhC; Provisional; Region: PRK12722 596153008616 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 596153008617 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 596153008618 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 596153008619 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 596153008620 domain interfaces; other site 596153008621 active site 596153008622 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 596153008623 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 596153008624 active site 596153008625 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 596153008626 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 596153008627 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 596153008628 D-pathway; other site 596153008629 Low-spin heme binding site [chemical binding]; other site 596153008630 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 596153008631 Putative water exit pathway; other site 596153008632 Binuclear center (active site) [active] 596153008633 K-pathway; other site 596153008634 Putative proton exit pathway; other site 596153008635 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 596153008636 Cytochrome c; Region: Cytochrom_C; pfam00034 596153008637 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 596153008638 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 596153008639 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 596153008640 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 596153008641 HIGH motif; other site 596153008642 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 596153008643 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 596153008644 active site 596153008645 KMSKS motif; other site 596153008646 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 596153008647 tRNA binding surface [nucleotide binding]; other site 596153008648 anticodon binding site; other site 596153008649 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 596153008650 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 596153008651 active site 596153008652 tetramer interface; other site 596153008653 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 596153008654 CPxP motif; other site 596153008655 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 596153008656 nudix motif; other site 596153008657 cysteine synthase B; Region: cysM; TIGR01138 596153008658 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 596153008659 dimer interface [polypeptide binding]; other site 596153008660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153008661 catalytic residue [active] 596153008662 Uncharacterized conserved small protein [Function unknown]; Region: COG5639 596153008663 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 596153008664 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 596153008665 VirB7 interaction site; other site 596153008666 conjugal transfer protein TrbF; Provisional; Region: PRK13872 596153008667 conjugal transfer protein TrbL; Provisional; Region: PRK13875 596153008668 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 596153008669 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 596153008670 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 596153008671 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 596153008672 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 596153008673 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 596153008674 Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268 596153008675 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 596153008676 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 596153008677 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 596153008678 ATP binding site [chemical binding]; other site 596153008679 Walker A motif; other site 596153008680 hexamer interface [polypeptide binding]; other site 596153008681 Walker B motif; other site 596153008682 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 596153008683 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 596153008684 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 596153008685 Walker A motif; other site 596153008686 ATP binding site [chemical binding]; other site 596153008687 Walker B motif; other site 596153008688 conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360 596153008689 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153008690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153008691 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 596153008692 dimerization interface [polypeptide binding]; other site 596153008693 substrate binding pocket [chemical binding]; other site 596153008694 PGAP1-like protein; Region: PGAP1; pfam07819 596153008695 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 596153008696 phosphate acetyltransferase; Provisional; Region: PRK11890 596153008697 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 596153008698 Ligand Binding Site [chemical binding]; other site 596153008699 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 596153008700 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 596153008701 NAD(P) binding site [chemical binding]; other site 596153008702 homotetramer interface [polypeptide binding]; other site 596153008703 homodimer interface [polypeptide binding]; other site 596153008704 active site 596153008705 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 596153008706 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 596153008707 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 596153008708 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 596153008709 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 596153008710 Peptidase C1-like family; Region: Peptidase_C1_2; cl17447 596153008711 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 596153008712 HlyD family secretion protein; Region: HlyD_3; pfam13437 596153008713 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 596153008714 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 596153008715 Walker A/P-loop; other site 596153008716 ATP binding site [chemical binding]; other site 596153008717 Q-loop/lid; other site 596153008718 ABC transporter signature motif; other site 596153008719 Walker B; other site 596153008720 D-loop; other site 596153008721 H-loop/switch region; other site 596153008722 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 596153008723 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 596153008724 Walker A/P-loop; other site 596153008725 ATP binding site [chemical binding]; other site 596153008726 Q-loop/lid; other site 596153008727 ABC transporter signature motif; other site 596153008728 Walker B; other site 596153008729 D-loop; other site 596153008730 H-loop/switch region; other site 596153008731 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 596153008732 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 596153008733 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 596153008734 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 596153008735 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 596153008736 putative alcohol dehydrogenase; Provisional; Region: PRK09860 596153008737 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 596153008738 dimer interface [polypeptide binding]; other site 596153008739 active site 596153008740 metal binding site [ion binding]; metal-binding site 596153008741 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 596153008742 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 596153008743 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 596153008744 Beta-Casp domain; Region: Beta-Casp; smart01027 596153008745 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 596153008746 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 596153008747 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 596153008748 Cytochrome C' Region: Cytochrom_C_2; cl01610 596153008749 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 596153008750 propionate/acetate kinase; Provisional; Region: PRK12379 596153008751 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 596153008752 XFP N-terminal domain; Region: XFP_N; pfam09364 596153008753 Putative zinc-finger; Region: zf-HC2; pfam13490 596153008754 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 596153008755 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 596153008756 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 596153008757 DNA binding residues [nucleotide binding] 596153008758 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 596153008759 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 596153008760 Flavodoxin; Region: Flavodoxin_1; pfam00258 596153008761 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 596153008762 FAD binding pocket [chemical binding]; other site 596153008763 FAD binding motif [chemical binding]; other site 596153008764 catalytic residues [active] 596153008765 NAD binding pocket [chemical binding]; other site 596153008766 phosphate binding motif [ion binding]; other site 596153008767 beta-alpha-beta structure motif; other site 596153008768 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 596153008769 ApbE family; Region: ApbE; pfam02424 596153008770 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 596153008771 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 596153008772 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 596153008773 ligand binding site [chemical binding]; other site 596153008774 flexible hinge region; other site 596153008775 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 596153008776 non-specific DNA interactions [nucleotide binding]; other site 596153008777 DNA binding site [nucleotide binding] 596153008778 sequence specific DNA binding site [nucleotide binding]; other site 596153008779 putative cAMP binding site [chemical binding]; other site 596153008780 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 596153008781 metal-binding site [ion binding] 596153008782 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 596153008783 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 596153008784 Soluble P-type ATPase [General function prediction only]; Region: COG4087 596153008785 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 596153008786 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 596153008787 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 596153008788 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 596153008789 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 596153008790 putative transposase OrfB; Reviewed; Region: PHA02517 596153008791 HTH-like domain; Region: HTH_21; pfam13276 596153008792 Integrase core domain; Region: rve; pfam00665 596153008793 Integrase core domain; Region: rve_3; cl15866 596153008794 Transposase; Region: HTH_Tnp_1; cl17663 596153008795 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153008796 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 596153008797 enoyl-CoA hydratase; Provisional; Region: PRK05995 596153008798 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153008799 substrate binding site [chemical binding]; other site 596153008800 oxyanion hole (OAH) forming residues; other site 596153008801 trimer interface [polypeptide binding]; other site 596153008802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 596153008803 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 596153008804 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153008805 acyl-activating enzyme (AAE) consensus motif; other site 596153008806 AMP binding site [chemical binding]; other site 596153008807 active site 596153008808 CoA binding site [chemical binding]; other site 596153008809 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 596153008810 active site 596153008811 catalytic residues [active] 596153008812 metal binding site [ion binding]; metal-binding site 596153008813 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 596153008814 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 596153008815 ATP-grasp domain; Region: ATP-grasp_4; cl17255 596153008816 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 596153008817 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 596153008818 carboxyltransferase (CT) interaction site; other site 596153008819 biotinylation site [posttranslational modification]; other site 596153008820 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 596153008821 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 596153008822 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 596153008823 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 596153008824 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153008825 acyl-activating enzyme (AAE) consensus motif; other site 596153008826 active site 596153008827 AMP binding site [chemical binding]; other site 596153008828 CoA binding site [chemical binding]; other site 596153008829 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 596153008830 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153008831 substrate binding site [chemical binding]; other site 596153008832 oxyanion hole (OAH) forming residues; other site 596153008833 trimer interface [polypeptide binding]; other site 596153008834 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 596153008835 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153008836 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 596153008837 putative ligand binding site [chemical binding]; other site 596153008838 SurA N-terminal domain; Region: SurA_N_3; cl07813 596153008839 periplasmic folding chaperone; Provisional; Region: PRK10788 596153008840 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 596153008841 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 596153008842 IHF dimer interface [polypeptide binding]; other site 596153008843 IHF - DNA interface [nucleotide binding]; other site 596153008844 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 596153008845 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 596153008846 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 596153008847 GIY-YIG motif/motif A; other site 596153008848 active site 596153008849 catalytic site [active] 596153008850 putative DNA binding site [nucleotide binding]; other site 596153008851 metal binding site [ion binding]; metal-binding site 596153008852 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 596153008853 H-NS histone family; Region: Histone_HNS; pfam00816 596153008854 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 596153008855 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 596153008856 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153008857 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 596153008858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153008859 NAD(P) binding site [chemical binding]; other site 596153008860 active site 596153008861 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153008862 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 596153008863 FAD binding site [chemical binding]; other site 596153008864 substrate binding site [chemical binding]; other site 596153008865 catalytic base [active] 596153008866 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 596153008867 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153008868 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 596153008869 acyl-activating enzyme (AAE) consensus motif; other site 596153008870 putative AMP binding site [chemical binding]; other site 596153008871 putative active site [active] 596153008872 putative CoA binding site [chemical binding]; other site 596153008873 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153008874 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 596153008875 putative ligand binding site [chemical binding]; other site 596153008876 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 596153008877 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 596153008878 Walker A/P-loop; other site 596153008879 ATP binding site [chemical binding]; other site 596153008880 Q-loop/lid; other site 596153008881 ABC transporter signature motif; other site 596153008882 Walker B; other site 596153008883 D-loop; other site 596153008884 H-loop/switch region; other site 596153008885 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 596153008886 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 596153008887 Walker A/P-loop; other site 596153008888 ATP binding site [chemical binding]; other site 596153008889 Q-loop/lid; other site 596153008890 ABC transporter signature motif; other site 596153008891 Walker B; other site 596153008892 D-loop; other site 596153008893 H-loop/switch region; other site 596153008894 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 596153008895 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 596153008896 TM-ABC transporter signature motif; other site 596153008897 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 596153008898 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 596153008899 TM-ABC transporter signature motif; other site 596153008900 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153008901 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 596153008902 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 596153008903 trimer interface [polypeptide binding]; other site 596153008904 eyelet of channel; other site 596153008905 Transmembrane secretion effector; Region: MFS_3; pfam05977 596153008906 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 596153008907 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153008908 substrate binding site [chemical binding]; other site 596153008909 oxyanion hole (OAH) forming residues; other site 596153008910 trimer interface [polypeptide binding]; other site 596153008911 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 596153008912 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 596153008913 NAD(P) binding site [chemical binding]; other site 596153008914 catalytic residues [active] 596153008915 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 596153008916 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 596153008917 NAD(P) binding site [chemical binding]; other site 596153008918 catalytic residues [active] 596153008919 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 596153008920 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153008921 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 596153008922 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 596153008923 NAD(P) binding site [chemical binding]; other site 596153008924 catalytic residues [active] 596153008925 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 596153008926 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 596153008927 putative NAD(P) binding site [chemical binding]; other site 596153008928 catalytic Zn binding site [ion binding]; other site 596153008929 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153008930 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 596153008931 ligand binding site [chemical binding]; other site 596153008932 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 596153008933 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 596153008934 TM-ABC transporter signature motif; other site 596153008935 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 596153008936 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 596153008937 TM-ABC transporter signature motif; other site 596153008938 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 596153008939 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 596153008940 Walker A/P-loop; other site 596153008941 ATP binding site [chemical binding]; other site 596153008942 Q-loop/lid; other site 596153008943 ABC transporter signature motif; other site 596153008944 Walker B; other site 596153008945 D-loop; other site 596153008946 H-loop/switch region; other site 596153008947 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 596153008948 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 596153008949 Walker A/P-loop; other site 596153008950 ATP binding site [chemical binding]; other site 596153008951 Q-loop/lid; other site 596153008952 ABC transporter signature motif; other site 596153008953 Walker B; other site 596153008954 D-loop; other site 596153008955 H-loop/switch region; other site 596153008956 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 596153008957 hydroxyglutarate oxidase; Provisional; Region: PRK11728 596153008958 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 596153008959 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 596153008960 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153008961 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153008962 Uncharacterized conserved protein [Function unknown]; Region: COG3777 596153008963 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 596153008964 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 596153008965 active site 2 [active] 596153008966 active site 1 [active] 596153008967 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 596153008968 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 596153008969 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 596153008970 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 596153008971 Ligand binding site [chemical binding]; other site 596153008972 Electron transfer flavoprotein domain; Region: ETF; pfam01012 596153008973 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153008974 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 596153008975 active site 596153008976 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153008977 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153008978 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 596153008979 putative dimerization interface [polypeptide binding]; other site 596153008980 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 596153008981 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153008982 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153008983 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 596153008984 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 596153008985 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 596153008986 acyl-activating enzyme (AAE) consensus motif; other site 596153008987 putative AMP binding site [chemical binding]; other site 596153008988 putative active site [active] 596153008989 putative CoA binding site [chemical binding]; other site 596153008990 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 596153008991 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 596153008992 dimer interface [polypeptide binding]; other site 596153008993 active site 596153008994 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 596153008995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153008996 NAD(P) binding site [chemical binding]; other site 596153008997 active site 596153008998 enoyl-CoA hydratase; Region: PLN02864 596153008999 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 596153009000 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 596153009001 dimer interaction site [polypeptide binding]; other site 596153009002 substrate-binding tunnel; other site 596153009003 active site 596153009004 catalytic site [active] 596153009005 substrate binding site [chemical binding]; other site 596153009006 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153009007 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153009008 active site 596153009009 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 596153009010 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 596153009011 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153009012 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 596153009013 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153009014 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153009015 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 596153009016 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153009017 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 596153009018 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 596153009019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153009020 choline dehydrogenase; Validated; Region: PRK02106 596153009021 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 596153009022 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 596153009023 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 596153009024 NAD binding site [chemical binding]; other site 596153009025 catalytic residues [active] 596153009026 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153009027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153009028 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153009029 dimerization interface [polypeptide binding]; other site 596153009030 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153009031 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153009032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153009033 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 596153009034 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153009035 substrate binding site [chemical binding]; other site 596153009036 oxyanion hole (OAH) forming residues; other site 596153009037 trimer interface [polypeptide binding]; other site 596153009038 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 596153009039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153009040 NAD(P) binding site [chemical binding]; other site 596153009041 active site 596153009042 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153009043 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153009044 active site 596153009045 MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: MaoC_like; cd03446 596153009046 homodimer interaction site [polypeptide binding]; other site 596153009047 putative active site [active] 596153009048 putative catalytic site [active] 596153009049 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 596153009050 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 596153009051 lipid-transfer protein; Provisional; Region: PRK08256 596153009052 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 596153009053 active site 596153009054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153009055 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153009056 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153009057 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153009058 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153009059 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 596153009060 active site 1 [active] 596153009061 active site 2 [active] 596153009062 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153009063 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153009064 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153009065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153009066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153009067 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153009068 dimerization interface [polypeptide binding]; other site 596153009069 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 596153009070 short chain dehydrogenase; Provisional; Region: PRK06125 596153009071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153009072 NAD(P) binding site [chemical binding]; other site 596153009073 active site 596153009074 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 596153009075 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 596153009076 phosphate binding site [ion binding]; other site 596153009077 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 596153009078 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 596153009079 Walker A/P-loop; other site 596153009080 ATP binding site [chemical binding]; other site 596153009081 Q-loop/lid; other site 596153009082 ABC transporter signature motif; other site 596153009083 Walker B; other site 596153009084 D-loop; other site 596153009085 H-loop/switch region; other site 596153009086 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 596153009087 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 596153009088 Walker A/P-loop; other site 596153009089 ATP binding site [chemical binding]; other site 596153009090 Q-loop/lid; other site 596153009091 ABC transporter signature motif; other site 596153009092 Walker B; other site 596153009093 D-loop; other site 596153009094 H-loop/switch region; other site 596153009095 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 596153009096 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 596153009097 TM-ABC transporter signature motif; other site 596153009098 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 596153009099 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 596153009100 TM-ABC transporter signature motif; other site 596153009101 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153009102 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 596153009103 putative ligand binding site [chemical binding]; other site 596153009104 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 596153009105 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153009106 substrate binding site [chemical binding]; other site 596153009107 oxyanion hole (OAH) forming residues; other site 596153009108 trimer interface [polypeptide binding]; other site 596153009109 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 596153009110 putative FMN binding site [chemical binding]; other site 596153009111 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 596153009112 SnoaL-like domain; Region: SnoaL_3; pfam13474 596153009113 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153009114 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153009115 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153009116 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153009117 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153009118 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153009119 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 596153009120 active site 596153009121 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 596153009122 putative active site [active] 596153009123 putative catalytic site [active] 596153009124 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 596153009125 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 596153009126 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 596153009127 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 596153009128 Found in ATP-dependent protease La (LON); Region: LON; smart00464 596153009129 Found in ATP-dependent protease La (LON); Region: LON; smart00464 596153009130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153009131 Walker A motif; other site 596153009132 ATP binding site [chemical binding]; other site 596153009133 Walker B motif; other site 596153009134 arginine finger; other site 596153009135 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 596153009136 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 596153009137 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 596153009138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153009139 Walker A motif; other site 596153009140 ATP binding site [chemical binding]; other site 596153009141 Walker B motif; other site 596153009142 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 596153009143 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 596153009144 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 596153009145 oligomer interface [polypeptide binding]; other site 596153009146 active site residues [active] 596153009147 trigger factor; Provisional; Region: tig; PRK01490 596153009148 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 596153009149 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 596153009150 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 596153009151 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 596153009152 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 596153009153 HlyD family secretion protein; Region: HlyD_3; pfam13437 596153009154 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 596153009155 active site lid residues [active] 596153009156 substrate binding pocket [chemical binding]; other site 596153009157 catalytic residues [active] 596153009158 substrate-Mg2+ binding site; other site 596153009159 aspartate-rich region 1; other site 596153009160 aspartate-rich region 2; other site 596153009161 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 596153009162 catalytic residues [active] 596153009163 substrate binding pocket [chemical binding]; other site 596153009164 substrate-Mg2+ binding site; other site 596153009165 aspartate-rich region 1; other site 596153009166 aspartate-rich region 2; other site 596153009167 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 596153009168 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 596153009169 dimer interface [polypeptide binding]; other site 596153009170 putative CheW interface [polypeptide binding]; other site 596153009171 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 596153009172 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 596153009173 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 596153009174 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 596153009175 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 596153009176 FAD binding domain; Region: FAD_binding_4; pfam01565 596153009177 thymidylate synthase; Reviewed; Region: thyA; PRK01827 596153009178 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 596153009179 dimerization interface [polypeptide binding]; other site 596153009180 active site 596153009181 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 596153009182 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 596153009183 folate binding site [chemical binding]; other site 596153009184 NADP+ binding site [chemical binding]; other site 596153009185 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 596153009186 hypothetical protein; Provisional; Region: PRK09040 596153009187 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 596153009188 ligand binding site [chemical binding]; other site 596153009189 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 596153009190 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 596153009191 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 596153009192 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 596153009193 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 596153009194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153009195 active site 596153009196 phosphorylation site [posttranslational modification] 596153009197 intermolecular recognition site; other site 596153009198 dimerization interface [polypeptide binding]; other site 596153009199 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 596153009200 DNA binding site [nucleotide binding] 596153009201 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 596153009202 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 596153009203 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 596153009204 Ligand Binding Site [chemical binding]; other site 596153009205 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 596153009206 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153009207 dimer interface [polypeptide binding]; other site 596153009208 phosphorylation site [posttranslational modification] 596153009209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153009210 ATP binding site [chemical binding]; other site 596153009211 Mg2+ binding site [ion binding]; other site 596153009212 G-X-G motif; other site 596153009213 K+-transporting ATPase, c chain; Region: KdpC; cl00944 596153009214 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 596153009215 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 596153009216 Soluble P-type ATPase [General function prediction only]; Region: COG4087 596153009217 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 596153009218 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 596153009219 putative catalytic site [active] 596153009220 putative phosphate binding site [ion binding]; other site 596153009221 active site 596153009222 metal binding site A [ion binding]; metal-binding site 596153009223 DNA binding site [nucleotide binding] 596153009224 putative AP binding site [nucleotide binding]; other site 596153009225 putative metal binding site B [ion binding]; other site 596153009226 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 596153009227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153009228 active site 596153009229 phosphorylation site [posttranslational modification] 596153009230 intermolecular recognition site; other site 596153009231 dimerization interface [polypeptide binding]; other site 596153009232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153009233 Walker A motif; other site 596153009234 ATP binding site [chemical binding]; other site 596153009235 Walker B motif; other site 596153009236 arginine finger; other site 596153009237 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 596153009238 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 596153009239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 596153009240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153009241 dimer interface [polypeptide binding]; other site 596153009242 phosphorylation site [posttranslational modification] 596153009243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153009244 ATP binding site [chemical binding]; other site 596153009245 Mg2+ binding site [ion binding]; other site 596153009246 G-X-G motif; other site 596153009247 glutamine synthetase; Provisional; Region: glnA; PRK09469 596153009248 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 596153009249 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 596153009250 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 596153009251 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 596153009252 putative MPT binding site; other site 596153009253 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 596153009254 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 596153009255 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 596153009256 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 596153009257 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 596153009258 NodB motif; other site 596153009259 active site 596153009260 catalytic site [active] 596153009261 metal binding site [ion binding]; metal-binding site 596153009262 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 596153009263 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 596153009264 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 596153009265 active site 596153009266 uracil binding [chemical binding]; other site 596153009267 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 596153009268 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 596153009269 active site 596153009270 adenylosuccinate synthetase; Provisional; Region: PRK01117 596153009271 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 596153009272 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 596153009273 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 596153009274 dimer interface [polypeptide binding]; other site 596153009275 motif 1; other site 596153009276 active site 596153009277 motif 2; other site 596153009278 motif 3; other site 596153009279 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 596153009280 HflC protein; Region: hflC; TIGR01932 596153009281 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 596153009282 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 596153009283 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 596153009284 HflK protein; Region: hflK; TIGR01933 596153009285 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 596153009286 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 596153009287 HflX GTPase family; Region: HflX; cd01878 596153009288 G1 box; other site 596153009289 GTP/Mg2+ binding site [chemical binding]; other site 596153009290 Switch I region; other site 596153009291 G2 box; other site 596153009292 G3 box; other site 596153009293 Switch II region; other site 596153009294 G4 box; other site 596153009295 G5 box; other site 596153009296 bacterial Hfq-like; Region: Hfq; cd01716 596153009297 hexamer interface [polypeptide binding]; other site 596153009298 Sm1 motif; other site 596153009299 RNA binding site [nucleotide binding]; other site 596153009300 Sm2 motif; other site 596153009301 GTP-binding protein Der; Reviewed; Region: PRK00093 596153009302 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 596153009303 G1 box; other site 596153009304 GTP/Mg2+ binding site [chemical binding]; other site 596153009305 Switch I region; other site 596153009306 G2 box; other site 596153009307 Switch II region; other site 596153009308 G3 box; other site 596153009309 G4 box; other site 596153009310 G5 box; other site 596153009311 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 596153009312 G1 box; other site 596153009313 GTP/Mg2+ binding site [chemical binding]; other site 596153009314 Switch I region; other site 596153009315 G2 box; other site 596153009316 G3 box; other site 596153009317 Switch II region; other site 596153009318 G4 box; other site 596153009319 G5 box; other site 596153009320 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 596153009321 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 596153009322 Trp docking motif [polypeptide binding]; other site 596153009323 active site 596153009324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 596153009325 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 596153009326 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 596153009327 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 596153009328 dimer interface [polypeptide binding]; other site 596153009329 motif 1; other site 596153009330 active site 596153009331 motif 2; other site 596153009332 motif 3; other site 596153009333 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 596153009334 anticodon binding site; other site 596153009335 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 596153009336 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 596153009337 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 596153009338 Helix-turn-helix domain; Region: HTH_25; pfam13413 596153009339 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 596153009340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 596153009341 binding surface 596153009342 TPR motif; other site 596153009343 TPR repeat; Region: TPR_11; pfam13414 596153009344 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 596153009345 binding surface 596153009346 TPR motif; other site 596153009347 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 596153009348 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 596153009349 FeS/SAM binding site; other site 596153009350 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 596153009351 active site 596153009352 multimer interface [polypeptide binding]; other site 596153009353 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 596153009354 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 596153009355 RNA binding surface [nucleotide binding]; other site 596153009356 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 596153009357 probable active site [active] 596153009358 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 596153009359 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 596153009360 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 596153009361 RNA binding surface [nucleotide binding]; other site 596153009362 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 596153009363 active site 596153009364 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 596153009365 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 596153009366 Peptidase family M23; Region: Peptidase_M23; pfam01551 596153009367 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 596153009368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153009369 S-adenosylmethionine binding site [chemical binding]; other site 596153009370 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 596153009371 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153009372 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153009373 metal binding site [ion binding]; metal-binding site 596153009374 active site 596153009375 I-site; other site 596153009376 PhoD-like phosphatase; Region: PhoD; pfam09423 596153009377 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 596153009378 putative active site [active] 596153009379 putative metal binding site [ion binding]; other site 596153009380 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 596153009381 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153009382 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153009383 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 596153009384 dimerization interface [polypeptide binding]; other site 596153009385 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 596153009386 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 596153009387 phosphate binding site [ion binding]; other site 596153009388 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153009389 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 596153009390 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 596153009391 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 596153009392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 596153009393 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 596153009394 MutS domain I; Region: MutS_I; pfam01624 596153009395 MutS domain II; Region: MutS_II; pfam05188 596153009396 MutS domain III; Region: MutS_III; pfam05192 596153009397 MutS domain V; Region: MutS_V; pfam00488 596153009398 Walker A/P-loop; other site 596153009399 ATP binding site [chemical binding]; other site 596153009400 Q-loop/lid; other site 596153009401 ABC transporter signature motif; other site 596153009402 Walker B; other site 596153009403 D-loop; other site 596153009404 H-loop/switch region; other site 596153009405 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 596153009406 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 596153009407 Protein export membrane protein; Region: SecD_SecF; cl14618 596153009408 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 596153009409 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 596153009410 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 596153009411 HlyD family secretion protein; Region: HlyD_3; pfam13437 596153009412 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 596153009413 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 596153009414 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 596153009415 2TM domain; Region: 2TM; pfam13239 596153009416 Histidine kinase; Region: His_kinase; pfam06580 596153009417 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 596153009418 ATP binding site [chemical binding]; other site 596153009419 Mg2+ binding site [ion binding]; other site 596153009420 G-X-G motif; other site 596153009421 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 596153009422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153009423 active site 596153009424 phosphorylation site [posttranslational modification] 596153009425 intermolecular recognition site; other site 596153009426 dimerization interface [polypeptide binding]; other site 596153009427 LytTr DNA-binding domain; Region: LytTR; smart00850 596153009428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153009429 Major Facilitator Superfamily; Region: MFS_1; pfam07690 596153009430 putative substrate translocation pore; other site 596153009431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153009432 Major Facilitator Superfamily; Region: MFS_1; pfam07690 596153009433 putative substrate translocation pore; other site 596153009434 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 596153009435 aconitate hydratase; Validated; Region: PRK09277 596153009436 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 596153009437 substrate binding site [chemical binding]; other site 596153009438 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 596153009439 ligand binding site [chemical binding]; other site 596153009440 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 596153009441 substrate binding site [chemical binding]; other site 596153009442 H-NS histone family; Region: Histone_HNS; pfam00816 596153009443 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 596153009444 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 596153009445 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 596153009446 active site 596153009447 metal binding site [ion binding]; metal-binding site 596153009448 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 596153009449 ApbE family; Region: ApbE; pfam02424 596153009450 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 596153009451 nitrous-oxide reductase; Validated; Region: PRK02888 596153009452 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 596153009453 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 596153009454 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 596153009455 4Fe-4S binding domain; Region: Fer4_5; pfam12801 596153009456 4Fe-4S binding domain; Region: Fer4_5; pfam12801 596153009457 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 596153009458 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 596153009459 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 596153009460 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 596153009461 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 596153009462 Walker A/P-loop; other site 596153009463 ATP binding site [chemical binding]; other site 596153009464 Q-loop/lid; other site 596153009465 ABC transporter signature motif; other site 596153009466 Walker B; other site 596153009467 D-loop; other site 596153009468 H-loop/switch region; other site 596153009469 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 596153009470 NosL; Region: NosL; pfam05573 596153009471 NosL; Region: NosL; cl01769 596153009472 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 596153009473 DEAD-like helicases superfamily; Region: DEXDc; smart00487 596153009474 ATP binding site [chemical binding]; other site 596153009475 Mg++ binding site [ion binding]; other site 596153009476 motif III; other site 596153009477 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 596153009478 nucleotide binding region [chemical binding]; other site 596153009479 ATP-binding site [chemical binding]; other site 596153009480 Predicted metalloprotease [General function prediction only]; Region: COG2321 596153009481 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 596153009482 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 596153009483 trimer interface [polypeptide binding]; other site 596153009484 active site 596153009485 Protein of unknown function (DUF989); Region: DUF989; pfam06181 596153009486 Predicted membrane protein [Function unknown]; Region: COG3748 596153009487 Cytochrome c; Region: Cytochrom_C; pfam00034 596153009488 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 596153009489 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 596153009490 XdhC Rossmann domain; Region: XdhC_C; pfam13478 596153009491 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 596153009492 active site 596153009493 homotetramer interface [polypeptide binding]; other site 596153009494 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 596153009495 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 596153009496 tartronate semialdehyde reductase; Provisional; Region: PRK15059 596153009497 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 596153009498 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 596153009499 glyoxylate carboligase; Provisional; Region: PRK11269 596153009500 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 596153009501 PYR/PP interface [polypeptide binding]; other site 596153009502 dimer interface [polypeptide binding]; other site 596153009503 TPP binding site [chemical binding]; other site 596153009504 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 596153009505 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 596153009506 TPP-binding site [chemical binding]; other site 596153009507 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153009508 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153009509 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 596153009510 putative effector binding pocket; other site 596153009511 dimerization interface [polypeptide binding]; other site 596153009512 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 596153009513 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 596153009514 substrate binding pocket [chemical binding]; other site 596153009515 membrane-bound complex binding site; other site 596153009516 hinge residues; other site 596153009517 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 596153009518 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 596153009519 inhibitor-cofactor binding pocket; inhibition site 596153009520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153009521 catalytic residue [active] 596153009522 cell density-dependent motility repressor; Provisional; Region: PRK10082 596153009523 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153009524 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 596153009525 dimerization interface [polypeptide binding]; other site 596153009526 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 596153009527 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 596153009528 MOFRL family; Region: MOFRL; pfam05161 596153009529 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153009530 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 596153009531 tartrate dehydrogenase; Region: TTC; TIGR02089 596153009532 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153009533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153009534 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 596153009535 putative effector binding pocket; other site 596153009536 putative dimerization interface [polypeptide binding]; other site 596153009537 Transcriptional regulators [Transcription]; Region: GntR; COG1802 596153009538 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153009539 DNA-binding site [nucleotide binding]; DNA binding site 596153009540 FCD domain; Region: FCD; pfam07729 596153009541 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 596153009542 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 596153009543 active site 596153009544 catalytic site [active] 596153009545 tetramer interface [polypeptide binding]; other site 596153009546 putative bifunctional OHCU decarboxylase/allantoate amidohydrolase; Provisional; Region: PRK13590 596153009547 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 596153009548 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 596153009549 active site 596153009550 metal binding site [ion binding]; metal-binding site 596153009551 dimer interface [polypeptide binding]; other site 596153009552 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 596153009553 M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697 596153009554 putative metal binding site [ion binding]; other site 596153009555 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 596153009556 dimer interface [polypeptide binding]; other site 596153009557 putative CheW interface [polypeptide binding]; other site 596153009558 xanthine permease; Region: pbuX; TIGR03173 596153009559 malic enzyme; Reviewed; Region: PRK12862 596153009560 Malic enzyme, N-terminal domain; Region: malic; pfam00390 596153009561 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 596153009562 putative NAD(P) binding site [chemical binding]; other site 596153009563 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 596153009564 Uncharacterized conserved protein [Function unknown]; Region: COG2353 596153009565 YceI-like domain; Region: YceI; smart00867 596153009566 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 596153009567 Protein of unknown function (DUF3334); Region: DUF3334; pfam11813 596153009568 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 596153009569 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 596153009570 catalytic triad [active] 596153009571 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 596153009572 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 596153009573 putative active site [active] 596153009574 PhoH-like protein; Region: PhoH; pfam02562 596153009575 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 596153009576 aldehyde dehydrogenase family 7 member; Region: PLN02315 596153009577 tetrameric interface [polypeptide binding]; other site 596153009578 NAD binding site [chemical binding]; other site 596153009579 catalytic residues [active] 596153009580 replicative DNA helicase; Region: DnaB; TIGR00665 596153009581 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 596153009582 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 596153009583 Walker A motif; other site 596153009584 ATP binding site [chemical binding]; other site 596153009585 Walker B motif; other site 596153009586 DNA binding loops [nucleotide binding] 596153009587 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 596153009588 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 596153009589 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 596153009590 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 596153009591 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 596153009592 generic binding surface I; other site 596153009593 generic binding surface II; other site 596153009594 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 596153009595 GrpE; Region: GrpE; pfam01025 596153009596 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 596153009597 dimer interface [polypeptide binding]; other site 596153009598 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 596153009599 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 596153009600 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 596153009601 nucleotide binding site [chemical binding]; other site 596153009602 chaperone protein DnaJ; Provisional; Region: PRK10767 596153009603 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 596153009604 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 596153009605 substrate binding site [polypeptide binding]; other site 596153009606 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 596153009607 Zn binding sites [ion binding]; other site 596153009608 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 596153009609 dimer interface [polypeptide binding]; other site 596153009610 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 596153009611 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 596153009612 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 596153009613 catalytic residue [active] 596153009614 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 596153009615 Peptidase family U32; Region: Peptidase_U32; pfam01136 596153009616 putative protease; Provisional; Region: PRK15447 596153009617 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 596153009618 SCP-2 sterol transfer family; Region: SCP2; cl01225 596153009619 DGC domain; Region: DGC; pfam08859 596153009620 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 596153009621 Flavoprotein; Region: Flavoprotein; pfam02441 596153009622 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 596153009623 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 596153009624 Cytochrome P450; Region: p450; cl12078 596153009625 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 596153009626 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 596153009627 Beta-Casp domain; Region: Beta-Casp; smart01027 596153009628 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 596153009629 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153009630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153009631 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 596153009632 putative dimerization interface [polypeptide binding]; other site 596153009633 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 596153009634 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 596153009635 substrate binding site [chemical binding]; other site 596153009636 ligand binding site [chemical binding]; other site 596153009637 Predicted small secreted protein [Function unknown]; Region: COG5510 596153009638 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 596153009639 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 596153009640 substrate binding site [chemical binding]; other site 596153009641 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 596153009642 tartrate dehydrogenase; Region: TTC; TIGR02089 596153009643 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 596153009644 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 596153009645 FimV N-terminal domain; Region: FimV_core; TIGR03505 596153009646 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 596153009647 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 596153009648 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 596153009649 dimerization interface 3.5A [polypeptide binding]; other site 596153009650 active site 596153009651 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 596153009652 active site 596153009653 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 596153009654 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 596153009655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153009656 catalytic residue [active] 596153009657 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 596153009658 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 596153009659 substrate binding site [chemical binding]; other site 596153009660 active site 596153009661 catalytic residues [active] 596153009662 heterodimer interface [polypeptide binding]; other site 596153009663 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 596153009664 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 596153009665 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 596153009666 YGGT family; Region: YGGT; pfam02325 596153009667 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 596153009668 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 596153009669 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 596153009670 NAD(P) binding site [chemical binding]; other site 596153009671 homodimer interface [polypeptide binding]; other site 596153009672 substrate binding site [chemical binding]; other site 596153009673 active site 596153009674 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 596153009675 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 596153009676 trimer interface [polypeptide binding]; other site 596153009677 active site 596153009678 substrate binding site [chemical binding]; other site 596153009679 CoA binding site [chemical binding]; other site 596153009680 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 596153009681 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 596153009682 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 596153009683 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 596153009684 Ligand binding site; other site 596153009685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153009686 S-adenosylmethionine binding site [chemical binding]; other site 596153009687 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 596153009688 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 596153009689 inhibitor-cofactor binding pocket; inhibition site 596153009690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153009691 catalytic residue [active] 596153009692 Bacterial sugar transferase; Region: Bac_transf; pfam02397 596153009693 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 596153009694 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 596153009695 dimer interface [polypeptide binding]; other site 596153009696 putative anticodon binding site; other site 596153009697 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 596153009698 motif 1; other site 596153009699 active site 596153009700 motif 2; other site 596153009701 motif 3; other site 596153009702 Mechanosensitive ion channel; Region: MS_channel; pfam00924 596153009703 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 596153009704 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 596153009705 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 596153009706 dimerization interface [polypeptide binding]; other site 596153009707 ligand binding site [chemical binding]; other site 596153009708 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 596153009709 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 596153009710 TM-ABC transporter signature motif; other site 596153009711 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 596153009712 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 596153009713 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 596153009714 TM-ABC transporter signature motif; other site 596153009715 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 596153009716 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 596153009717 Walker A/P-loop; other site 596153009718 ATP binding site [chemical binding]; other site 596153009719 Q-loop/lid; other site 596153009720 ABC transporter signature motif; other site 596153009721 Walker B; other site 596153009722 D-loop; other site 596153009723 H-loop/switch region; other site 596153009724 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 596153009725 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 596153009726 Walker A/P-loop; other site 596153009727 ATP binding site [chemical binding]; other site 596153009728 Q-loop/lid; other site 596153009729 ABC transporter signature motif; other site 596153009730 Walker B; other site 596153009731 D-loop; other site 596153009732 H-loop/switch region; other site 596153009733 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 596153009734 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 596153009735 active site 596153009736 ADP/pyrophosphate binding site [chemical binding]; other site 596153009737 dimerization interface [polypeptide binding]; other site 596153009738 allosteric effector site; other site 596153009739 fructose-1,6-bisphosphate binding site; other site 596153009740 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 596153009741 beta-hexosaminidase; Provisional; Region: PRK05337 596153009742 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 596153009743 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 596153009744 active site 596153009745 hydrophilic channel; other site 596153009746 dimerization interface [polypeptide binding]; other site 596153009747 catalytic residues [active] 596153009748 active site lid [active] 596153009749 Recombination protein O N terminal; Region: RecO_N; pfam11967 596153009750 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 596153009751 Recombination protein O C terminal; Region: RecO_C; pfam02565 596153009752 GTPase Era; Reviewed; Region: era; PRK00089 596153009753 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 596153009754 G1 box; other site 596153009755 GTP/Mg2+ binding site [chemical binding]; other site 596153009756 Switch I region; other site 596153009757 G2 box; other site 596153009758 Switch II region; other site 596153009759 G3 box; other site 596153009760 G4 box; other site 596153009761 G5 box; other site 596153009762 KH domain; Region: KH_2; pfam07650 596153009763 ribonuclease III; Reviewed; Region: rnc; PRK00102 596153009764 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 596153009765 dimerization interface [polypeptide binding]; other site 596153009766 active site 596153009767 metal binding site [ion binding]; metal-binding site 596153009768 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 596153009769 signal peptidase I; Provisional; Region: PRK10861 596153009770 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 596153009771 Catalytic site [active] 596153009772 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 596153009773 GTP-binding protein LepA; Provisional; Region: PRK05433 596153009774 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 596153009775 G1 box; other site 596153009776 putative GEF interaction site [polypeptide binding]; other site 596153009777 GTP/Mg2+ binding site [chemical binding]; other site 596153009778 Switch I region; other site 596153009779 G2 box; other site 596153009780 G3 box; other site 596153009781 Switch II region; other site 596153009782 G4 box; other site 596153009783 G5 box; other site 596153009784 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 596153009785 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 596153009786 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 596153009787 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 596153009788 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 596153009789 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 596153009790 protein binding site [polypeptide binding]; other site 596153009791 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 596153009792 protein binding site [polypeptide binding]; other site 596153009793 MucB/RseB family; Region: MucB_RseB; pfam03888 596153009794 anti-sigma E factor; Provisional; Region: rseB; PRK09455 596153009795 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 596153009796 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 596153009797 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 596153009798 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 596153009799 DNA binding residues [nucleotide binding] 596153009800 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 596153009801 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 596153009802 dimer interface [polypeptide binding]; other site 596153009803 active site 596153009804 acyl carrier protein; Provisional; Region: acpP; PRK00982 596153009805 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 596153009806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153009807 NAD(P) binding site [chemical binding]; other site 596153009808 active site 596153009809 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 596153009810 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 596153009811 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 596153009812 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 596153009813 dimer interface [polypeptide binding]; other site 596153009814 active site 596153009815 CoA binding pocket [chemical binding]; other site 596153009816 putative phosphate acyltransferase; Provisional; Region: PRK05331 596153009817 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 596153009818 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 596153009819 Maf-like protein; Region: Maf; pfam02545 596153009820 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 596153009821 active site 596153009822 dimer interface [polypeptide binding]; other site 596153009823 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 596153009824 putative SAM binding site [chemical binding]; other site 596153009825 homodimer interface [polypeptide binding]; other site 596153009826 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 596153009827 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 596153009828 tandem repeat interface [polypeptide binding]; other site 596153009829 oligomer interface [polypeptide binding]; other site 596153009830 active site residues [active] 596153009831 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 596153009832 iron-sulfur cluster [ion binding]; other site 596153009833 [2Fe-2S] cluster binding site [ion binding]; other site 596153009834 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 596153009835 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 596153009836 motif II; other site 596153009837 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 596153009838 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 596153009839 active site 596153009840 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 596153009841 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 596153009842 homodimer interface [polypeptide binding]; other site 596153009843 oligonucleotide binding site [chemical binding]; other site 596153009844 hypothetical protein; Validated; Region: PRK02101 596153009845 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 596153009846 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 596153009847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 596153009848 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 596153009849 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153009850 PAS domain; Region: PAS_9; pfam13426 596153009851 putative active site [active] 596153009852 heme pocket [chemical binding]; other site 596153009853 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 596153009854 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 596153009855 dimer interface [polypeptide binding]; other site 596153009856 putative CheW interface [polypeptide binding]; other site 596153009857 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 596153009858 active site 596153009859 DNA polymerase IV; Validated; Region: PRK02406 596153009860 DNA binding site [nucleotide binding] 596153009861 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 596153009862 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153009863 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 596153009864 putative dimerization interface [polypeptide binding]; other site 596153009865 putative substrate binding pocket [chemical binding]; other site 596153009866 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153009867 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153009868 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153009869 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153009870 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153009871 active site 596153009872 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 596153009873 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 596153009874 phosphate binding site [ion binding]; other site 596153009875 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 596153009876 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 596153009877 ligand binding site [chemical binding]; other site 596153009878 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153009879 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153009880 metal binding site [ion binding]; metal-binding site 596153009881 active site 596153009882 I-site; other site 596153009883 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 596153009884 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 596153009885 Transglycosylase; Region: Transgly; pfam00912 596153009886 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 596153009887 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 596153009888 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 596153009889 substrate binding site [chemical binding]; other site 596153009890 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 596153009891 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153009892 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153009893 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153009894 active site 596153009895 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 596153009896 CoA binding domain; Region: CoA_binding_2; pfam13380 596153009897 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 596153009898 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 596153009899 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153009900 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153009901 active site 596153009902 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 596153009903 active site 596153009904 homotetramer interface [polypeptide binding]; other site 596153009905 homodimer interface [polypeptide binding]; other site 596153009906 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153009907 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153009908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153009909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153009910 dimerization interface [polypeptide binding]; other site 596153009911 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 596153009912 active site 596153009913 metal binding site [ion binding]; metal-binding site 596153009914 Bacterial Ig-like domain; Region: Big_5; pfam13205 596153009915 Bacterial Ig-like domain; Region: Big_5; pfam13205 596153009916 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 596153009917 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 596153009918 MG2 domain; Region: A2M_N; pfam01835 596153009919 Alpha-2-macroglobulin family; Region: A2M; pfam00207 596153009920 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153009921 argininosuccinate lyase; Provisional; Region: PRK00855 596153009922 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 596153009923 active sites [active] 596153009924 tetramer interface [polypeptide binding]; other site 596153009925 Histidine kinase; Region: His_kinase; pfam06580 596153009926 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 596153009927 ATP binding site [chemical binding]; other site 596153009928 Mg2+ binding site [ion binding]; other site 596153009929 G-X-G motif; other site 596153009930 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 596153009931 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 596153009932 SpoVR family protein; Provisional; Region: PRK11767 596153009933 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 596153009934 hypothetical protein; Provisional; Region: PRK05325 596153009935 PrkA family serine protein kinase; Provisional; Region: PRK15455 596153009936 AAA ATPase domain; Region: AAA_16; pfam13191 596153009937 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 596153009938 Transcriptional regulator; Region: Rrf2; cl17282 596153009939 Rrf2 family protein; Region: rrf2_super; TIGR00738 596153009940 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 596153009941 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 596153009942 Hemerythrin-like domain; Region: Hr-like; cd12108 596153009943 Fe binding site [ion binding]; other site 596153009944 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 596153009945 heme-binding site [chemical binding]; other site 596153009946 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 596153009947 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 596153009948 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 596153009949 active site 596153009950 catalytic tetrad [active] 596153009951 SlyX; Region: SlyX; pfam04102 596153009952 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 596153009953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 596153009954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153009955 homodimer interface [polypeptide binding]; other site 596153009956 catalytic residue [active] 596153009957 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 596153009958 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153009959 amidase; Provisional; Region: PRK07486 596153009960 Amidase; Region: Amidase; cl11426 596153009961 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153009962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153009963 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153009964 dimerization interface [polypeptide binding]; other site 596153009965 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 596153009966 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 596153009967 minor groove reading motif; other site 596153009968 helix-hairpin-helix signature motif; other site 596153009969 substrate binding pocket [chemical binding]; other site 596153009970 active site 596153009971 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 596153009972 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 596153009973 ADP-ribose binding site [chemical binding]; other site 596153009974 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 596153009975 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 596153009976 active site pocket [active] 596153009977 putative dimer interface [polypeptide binding]; other site 596153009978 putative cataytic base [active] 596153009979 cobyric acid synthase; Provisional; Region: PRK00784 596153009980 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 596153009981 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 596153009982 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 596153009983 catalytic triad [active] 596153009984 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 596153009985 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 596153009986 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 596153009987 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 596153009988 catalytic residue [active] 596153009989 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 596153009990 Type II transport protein GspH; Region: GspH; pfam12019 596153009991 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 596153009992 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 596153009993 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 596153009994 PilX N-terminal; Region: PilX_N; pfam14341 596153009995 Type IV pilus assembly protein PilX C-term; Region: PilX; pfam13681 596153009996 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 596153009997 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 596153009998 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 596153009999 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 596153010000 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 596153010001 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 596153010002 catalytic motif [active] 596153010003 Zn binding site [ion binding]; other site 596153010004 RibD C-terminal domain; Region: RibD_C; cl17279 596153010005 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 596153010006 putative active site [active] 596153010007 catalytic site [active] 596153010008 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 596153010009 PLD-like domain; Region: PLDc_2; pfam13091 596153010010 putative active site [active] 596153010011 catalytic site [active] 596153010012 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 596153010013 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 596153010014 FMN binding site [chemical binding]; other site 596153010015 active site 596153010016 catalytic residues [active] 596153010017 substrate binding site [chemical binding]; other site 596153010018 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 596153010019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153010020 S-adenosylmethionine binding site [chemical binding]; other site 596153010021 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 596153010022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 596153010023 Coenzyme A binding pocket [chemical binding]; other site 596153010024 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 596153010025 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 596153010026 NAD(P) binding site [chemical binding]; other site 596153010027 catalytic residues [active] 596153010028 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 596153010029 Clp amino terminal domain; Region: Clp_N; pfam02861 596153010030 Clp amino terminal domain; Region: Clp_N; pfam02861 596153010031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153010032 Walker A motif; other site 596153010033 ATP binding site [chemical binding]; other site 596153010034 Walker B motif; other site 596153010035 arginine finger; other site 596153010036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153010037 Walker A motif; other site 596153010038 ATP binding site [chemical binding]; other site 596153010039 Walker B motif; other site 596153010040 arginine finger; other site 596153010041 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 596153010042 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 596153010043 MoaE homodimer interface [polypeptide binding]; other site 596153010044 MoaD interaction [polypeptide binding]; other site 596153010045 active site residues [active] 596153010046 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 596153010047 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 596153010048 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 596153010049 dimer interface [polypeptide binding]; other site 596153010050 active site 596153010051 catalytic residue [active] 596153010052 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 596153010053 MoaE interaction surface [polypeptide binding]; other site 596153010054 MoeB interaction surface [polypeptide binding]; other site 596153010055 thiocarboxylated glycine; other site 596153010056 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 596153010057 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 596153010058 dimer interface [polypeptide binding]; other site 596153010059 putative functional site; other site 596153010060 putative MPT binding site; other site 596153010061 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 596153010062 Walker A motif; other site 596153010063 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 596153010064 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 596153010065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153010066 catalytic residue [active] 596153010067 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 596153010068 oligomeric interface; other site 596153010069 putative active site [active] 596153010070 homodimer interface [polypeptide binding]; other site 596153010071 prevent-host-death family protein; Region: phd_fam; TIGR01552 596153010072 homoserine dehydrogenase; Provisional; Region: PRK06349 596153010073 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 596153010074 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 596153010075 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 596153010076 aminotransferase AlaT; Validated; Region: PRK09265 596153010077 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 596153010078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153010079 homodimer interface [polypeptide binding]; other site 596153010080 catalytic residue [active] 596153010081 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 596153010082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153010083 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 596153010084 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 596153010085 FAD binding site [chemical binding]; other site 596153010086 substrate binding site [chemical binding]; other site 596153010087 catalytic base [active] 596153010088 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 596153010089 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 596153010090 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 596153010091 active site 596153010092 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 596153010093 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 596153010094 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 596153010095 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 596153010096 Ligand binding site [chemical binding]; other site 596153010097 Electron transfer flavoprotein domain; Region: ETF; pfam01012 596153010098 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 596153010099 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153010100 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 596153010101 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 596153010102 dimer interface [polypeptide binding]; other site 596153010103 active site 596153010104 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 596153010105 DUF35 OB-fold domain; Region: DUF35; pfam01796 596153010106 thiolase; Provisional; Region: PRK06158 596153010107 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 596153010108 active site 596153010109 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 596153010110 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153010111 substrate binding site [chemical binding]; other site 596153010112 oxyanion hole (OAH) forming residues; other site 596153010113 trimer interface [polypeptide binding]; other site 596153010114 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153010115 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153010116 active site 596153010117 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 596153010118 CoA binding domain; Region: CoA_binding_2; pfam13380 596153010119 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 596153010120 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 596153010121 DUF35 OB-fold domain; Region: DUF35; pfam01796 596153010122 thiolase; Provisional; Region: PRK06158 596153010123 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 596153010124 active site 596153010125 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 596153010126 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153010127 substrate binding site [chemical binding]; other site 596153010128 oxyanion hole (OAH) forming residues; other site 596153010129 trimer interface [polypeptide binding]; other site 596153010130 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153010131 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 596153010132 substrate binding site [chemical binding]; other site 596153010133 oxyanion hole (OAH) forming residues; other site 596153010134 trimer interface [polypeptide binding]; other site 596153010135 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 596153010136 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 596153010137 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 596153010138 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 596153010139 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153010140 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153010141 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153010142 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153010143 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 596153010144 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153010145 active site 596153010146 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 596153010147 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153010148 substrate binding site [chemical binding]; other site 596153010149 oxyanion hole (OAH) forming residues; other site 596153010150 trimer interface [polypeptide binding]; other site 596153010151 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 596153010152 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153010153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153010154 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 596153010155 NAD(P) binding site [chemical binding]; other site 596153010156 active site 596153010157 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153010158 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153010159 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 596153010160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153010161 NAD(P) binding site [chemical binding]; other site 596153010162 active site 596153010163 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 596153010164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153010165 NAD(P) binding site [chemical binding]; other site 596153010166 active site 596153010167 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153010168 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153010169 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153010170 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 596153010171 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 596153010172 active site 596153010173 FMN binding site [chemical binding]; other site 596153010174 substrate binding site [chemical binding]; other site 596153010175 homotetramer interface [polypeptide binding]; other site 596153010176 catalytic residue [active] 596153010177 Methyltransferase domain; Region: Methyltransf_31; pfam13847 596153010178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153010179 S-adenosylmethionine binding site [chemical binding]; other site 596153010180 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 596153010181 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 596153010182 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 596153010183 DNA binding site [nucleotide binding] 596153010184 active site 596153010185 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 596153010186 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 596153010187 homodimer interface [polypeptide binding]; other site 596153010188 Walker A motif; other site 596153010189 ATP binding site [chemical binding]; other site 596153010190 hydroxycobalamin binding site [chemical binding]; other site 596153010191 Walker B motif; other site 596153010192 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 596153010193 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 596153010194 Walker A/P-loop; other site 596153010195 ATP binding site [chemical binding]; other site 596153010196 Q-loop/lid; other site 596153010197 ABC transporter signature motif; other site 596153010198 Walker B; other site 596153010199 D-loop; other site 596153010200 H-loop/switch region; other site 596153010201 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 596153010202 dimer interface [polypeptide binding]; other site 596153010203 putative PBP binding regions; other site 596153010204 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 596153010205 ABC-ATPase subunit interface; other site 596153010206 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 596153010207 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 596153010208 intersubunit interface [polypeptide binding]; other site 596153010209 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 596153010210 homotrimer interface [polypeptide binding]; other site 596153010211 Walker A motif; other site 596153010212 GTP binding site [chemical binding]; other site 596153010213 Walker B motif; other site 596153010214 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 596153010215 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 596153010216 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 596153010217 catalytic triad [active] 596153010218 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 596153010219 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 596153010220 N-terminal plug; other site 596153010221 ligand-binding site [chemical binding]; other site 596153010222 Cell division protein ZapA; Region: ZapA; pfam05164 596153010223 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 596153010224 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 596153010225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153010226 PAS domain; Region: PAS_9; pfam13426 596153010227 putative active site [active] 596153010228 heme pocket [chemical binding]; other site 596153010229 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153010230 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153010231 metal binding site [ion binding]; metal-binding site 596153010232 active site 596153010233 I-site; other site 596153010234 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 596153010235 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 596153010236 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 596153010237 Zn2+ binding site [ion binding]; other site 596153010238 Mg2+ binding site [ion binding]; other site 596153010239 Family description; Region: DsbD_2; pfam13386 596153010240 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 596153010241 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 596153010242 FeS/SAM binding site; other site 596153010243 HemN C-terminal domain; Region: HemN_C; pfam06969 596153010244 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 596153010245 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 596153010246 ligand binding site [chemical binding]; other site 596153010247 flexible hinge region; other site 596153010248 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 596153010249 putative switch regulator; other site 596153010250 non-specific DNA interactions [nucleotide binding]; other site 596153010251 DNA binding site [nucleotide binding] 596153010252 sequence specific DNA binding site [nucleotide binding]; other site 596153010253 putative cAMP binding site [chemical binding]; other site 596153010254 FixH; Region: FixH; pfam05751 596153010255 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 596153010256 4Fe-4S binding domain; Region: Fer4_5; pfam12801 596153010257 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 596153010258 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 596153010259 Cytochrome c; Region: Cytochrom_C; pfam00034 596153010260 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 596153010261 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 596153010262 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 596153010263 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 596153010264 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 596153010265 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 596153010266 Low-spin heme binding site [chemical binding]; other site 596153010267 Putative water exit pathway; other site 596153010268 Binuclear center (active site) [active] 596153010269 Putative proton exit pathway; other site 596153010270 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 596153010271 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 596153010272 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 596153010273 metal-binding site [ion binding] 596153010274 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 596153010275 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 596153010276 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 596153010277 Ligand Binding Site [chemical binding]; other site 596153010278 malonyl-CoA synthase; Validated; Region: PRK07514 596153010279 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 596153010280 acyl-activating enzyme (AAE) consensus motif; other site 596153010281 active site 596153010282 AMP binding site [chemical binding]; other site 596153010283 CoA binding site [chemical binding]; other site 596153010284 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153010285 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 596153010286 substrate binding site [chemical binding]; other site 596153010287 oxyanion hole (OAH) forming residues; other site 596153010288 trimer interface [polypeptide binding]; other site 596153010289 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153010290 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 596153010291 Transcriptional regulators [Transcription]; Region: GntR; COG1802 596153010292 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153010293 DNA-binding site [nucleotide binding]; DNA binding site 596153010294 FCD domain; Region: FCD; pfam07729 596153010295 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 596153010296 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 596153010297 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 596153010298 heme binding site [chemical binding]; other site 596153010299 ferroxidase pore; other site 596153010300 ferroxidase diiron center [ion binding]; other site 596153010301 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 596153010302 CoenzymeA binding site [chemical binding]; other site 596153010303 subunit interaction site [polypeptide binding]; other site 596153010304 PHB binding site; other site 596153010305 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 596153010306 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 596153010307 Cytochrome c; Region: Cytochrom_C; cl11414 596153010308 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 596153010309 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 596153010310 Walker A/P-loop; other site 596153010311 ATP binding site [chemical binding]; other site 596153010312 Q-loop/lid; other site 596153010313 ABC transporter signature motif; other site 596153010314 Walker B; other site 596153010315 D-loop; other site 596153010316 H-loop/switch region; other site 596153010317 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 596153010318 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 596153010319 FtsX-like permease family; Region: FtsX; pfam02687 596153010320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 596153010321 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 596153010322 DHH family; Region: DHH; pfam01368 596153010323 DHHA1 domain; Region: DHHA1; pfam02272 596153010324 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 596153010325 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 596153010326 dimerization interface [polypeptide binding]; other site 596153010327 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 596153010328 dimer interface [polypeptide binding]; other site 596153010329 putative CheW interface [polypeptide binding]; other site 596153010330 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 596153010331 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 596153010332 active site 596153010333 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 596153010334 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 596153010335 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 596153010336 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 596153010337 dimer interface [polypeptide binding]; other site 596153010338 putative CheW interface [polypeptide binding]; other site 596153010339 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 596153010340 Peptidase family M50; Region: Peptidase_M50; pfam02163 596153010341 active site 596153010342 putative substrate binding region [chemical binding]; other site 596153010343 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 596153010344 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 596153010345 active site 596153010346 HIGH motif; other site 596153010347 dimer interface [polypeptide binding]; other site 596153010348 KMSKS motif; other site 596153010349 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 596153010350 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 596153010351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153010352 active site 596153010353 phosphorylation site [posttranslational modification] 596153010354 intermolecular recognition site; other site 596153010355 dimerization interface [polypeptide binding]; other site 596153010356 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 596153010357 DNA binding site [nucleotide binding] 596153010358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 596153010359 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 596153010360 FecR protein; Region: FecR; pfam04773 596153010361 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 596153010362 CHASE2 domain; Region: CHASE2; pfam05226 596153010363 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 596153010364 dimer interface [polypeptide binding]; other site 596153010365 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 596153010366 phosphorylation site [posttranslational modification] 596153010367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153010368 ATP binding site [chemical binding]; other site 596153010369 Mg2+ binding site [ion binding]; other site 596153010370 G-X-G motif; other site 596153010371 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 596153010372 Bacterial sugar transferase; Region: Bac_transf; pfam02397 596153010373 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 596153010374 seryl-tRNA synthetase; Provisional; Region: PRK05431 596153010375 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 596153010376 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 596153010377 dimer interface [polypeptide binding]; other site 596153010378 active site 596153010379 motif 1; other site 596153010380 motif 2; other site 596153010381 motif 3; other site 596153010382 FOG: CBS domain [General function prediction only]; Region: COG0517 596153010383 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 596153010384 Domain of unknown function DUF21; Region: DUF21; pfam01595 596153010385 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 596153010386 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 596153010387 Transporter associated domain; Region: CorC_HlyC; smart01091 596153010388 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 596153010389 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 596153010390 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 596153010391 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 596153010392 hypothetical protein; Reviewed; Region: PRK00024 596153010393 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 596153010394 MPN+ (JAMM) motif; other site 596153010395 Zinc-binding site [ion binding]; other site 596153010396 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 596153010397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 596153010398 Smr domain; Region: Smr; pfam01713 596153010399 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153010400 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 596153010401 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 596153010402 substrate binding site [chemical binding]; other site 596153010403 ligand binding site [chemical binding]; other site 596153010404 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 596153010405 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 596153010406 hypothetical protein; Provisional; Region: PRK14812 596153010407 substrate binding site [chemical binding]; other site 596153010408 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 596153010409 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 596153010410 tetramer interface [polypeptide binding]; other site 596153010411 active site 596153010412 Mg2+/Mn2+ binding site [ion binding]; other site 596153010413 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 596153010414 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153010415 DNA-binding site [nucleotide binding]; DNA binding site 596153010416 UTRA domain; Region: UTRA; pfam07702 596153010417 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 596153010418 apolar tunnel; other site 596153010419 heme binding site [chemical binding]; other site 596153010420 dimerization interface [polypeptide binding]; other site 596153010421 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 596153010422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 596153010423 AAA domain; Region: AAA_33; pfam13671 596153010424 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 596153010425 active site 596153010426 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 596153010427 FtsX-like permease family; Region: FtsX; pfam02687 596153010428 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 596153010429 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 596153010430 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 596153010431 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 596153010432 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 596153010433 [4Fe-4S] binding site [ion binding]; other site 596153010434 molybdopterin cofactor binding site; other site 596153010435 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 596153010436 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 596153010437 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 596153010438 molybdopterin cofactor binding site; other site 596153010439 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 596153010440 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 596153010441 4Fe-4S binding domain; Region: Fer4; pfam00037 596153010442 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 596153010443 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 596153010444 4Fe-4S binding domain; Region: Fer4; pfam00037 596153010445 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 596153010446 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 596153010447 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 596153010448 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 596153010449 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 596153010450 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 596153010451 catalytic loop [active] 596153010452 iron binding site [ion binding]; other site 596153010453 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 596153010454 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 596153010455 [4Fe-4S] binding site [ion binding]; other site 596153010456 molybdopterin cofactor binding site; other site 596153010457 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 596153010458 molybdopterin cofactor binding site; other site 596153010459 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 596153010460 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 596153010461 putative dimer interface [polypeptide binding]; other site 596153010462 [2Fe-2S] cluster binding site [ion binding]; other site 596153010463 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 596153010464 SLBB domain; Region: SLBB; pfam10531 596153010465 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 596153010466 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 596153010467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153010468 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 596153010469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153010470 DNA-binding site [nucleotide binding]; DNA binding site 596153010471 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 596153010472 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153010473 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153010474 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153010475 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153010476 active site 596153010477 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 596153010478 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153010479 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 596153010480 putative active site [active] 596153010481 putative catalytic site [active] 596153010482 Domain of unknown function DUF59; Region: DUF59; pfam01883 596153010483 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 596153010484 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 596153010485 Walker A motif; other site 596153010486 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 596153010487 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 596153010488 gating phenylalanine in ion channel; other site 596153010489 selenophosphate synthetase; Provisional; Region: PRK00943 596153010490 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 596153010491 dimerization interface [polypeptide binding]; other site 596153010492 putative ATP binding site [chemical binding]; other site 596153010493 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 596153010494 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 596153010495 active site residue [active] 596153010496 Restriction endonuclease; Region: Mrr_cat; pfam04471 596153010497 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 596153010498 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 596153010499 active site 596153010500 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 596153010501 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 596153010502 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 596153010503 active site 596153010504 HIGH motif; other site 596153010505 KMSKS motif; other site 596153010506 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 596153010507 tRNA binding surface [nucleotide binding]; other site 596153010508 anticodon binding site; other site 596153010509 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 596153010510 dimer interface [polypeptide binding]; other site 596153010511 putative tRNA-binding site [nucleotide binding]; other site 596153010512 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 596153010513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153010514 DNA-binding site [nucleotide binding]; DNA binding site 596153010515 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 596153010516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153010517 homodimer interface [polypeptide binding]; other site 596153010518 catalytic residue [active] 596153010519 benzoate transporter; Region: benE; TIGR00843 596153010520 Benzoate membrane transport protein; Region: BenE; pfam03594 596153010521 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 596153010522 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 596153010523 catalytic residue [active] 596153010524 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 596153010525 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 596153010526 catalytic triad [active] 596153010527 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 596153010528 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 596153010529 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 596153010530 hypothetical protein; Validated; Region: PRK07121 596153010531 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 596153010532 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 596153010533 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 596153010534 phosphate binding site [ion binding]; other site 596153010535 hypothetical protein; Validated; Region: PRK07586 596153010536 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 596153010537 PYR/PP interface [polypeptide binding]; other site 596153010538 dimer interface [polypeptide binding]; other site 596153010539 TPP binding site [chemical binding]; other site 596153010540 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 596153010541 TPP-binding site [chemical binding]; other site 596153010542 dimer interface [polypeptide binding]; other site 596153010543 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 596153010544 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 596153010545 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 596153010546 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 596153010547 Cupin; Region: Cupin_6; pfam12852 596153010548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 596153010549 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 596153010550 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 596153010551 L-aspartate oxidase; Provisional; Region: PRK09077 596153010552 L-aspartate oxidase; Provisional; Region: PRK06175 596153010553 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 596153010554 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 596153010555 putative substrate binding pocket [chemical binding]; other site 596153010556 trimer interface [polypeptide binding]; other site 596153010557 chorismate binding enzyme; Region: Chorismate_bind; cl10555 596153010558 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 596153010559 substrate-cofactor binding pocket; other site 596153010560 homodimer interface [polypeptide binding]; other site 596153010561 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 596153010562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153010563 catalytic residue [active] 596153010564 quinolinate synthetase; Provisional; Region: PRK09375 596153010565 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 596153010566 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 596153010567 dimerization interface [polypeptide binding]; other site 596153010568 active site 596153010569 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 596153010570 oligomerization interface [polypeptide binding]; other site 596153010571 active site 596153010572 metal binding site [ion binding]; metal-binding site 596153010573 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 596153010574 pantoate--beta-alanine ligase; Region: panC; TIGR00018 596153010575 active site 596153010576 nucleotide binding site [chemical binding]; other site 596153010577 HIGH motif; other site 596153010578 KMSKS motif; other site 596153010579 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153010580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153010581 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 596153010582 dimerization interface [polypeptide binding]; other site 596153010583 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153010584 Uncharacterized conserved protein [Function unknown]; Region: COG5476 596153010585 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 596153010586 MlrC C-terminus; Region: MlrC_C; pfam07171 596153010587 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 596153010588 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153010589 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 596153010590 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 596153010591 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 596153010592 preprotein translocase subunit SecB; Validated; Region: PRK05751 596153010593 SecA binding site; other site 596153010594 Preprotein binding site; other site 596153010595 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 596153010596 GSH binding site [chemical binding]; other site 596153010597 catalytic residues [active] 596153010598 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 596153010599 active site residue [active] 596153010600 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 596153010601 catalytic core [active] 596153010602 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 596153010603 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 596153010604 C-terminal peptidase (prc); Region: prc; TIGR00225 596153010605 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 596153010606 protein binding site [polypeptide binding]; other site 596153010607 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 596153010608 Catalytic dyad [active] 596153010609 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 596153010610 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 596153010611 ATP binding site [chemical binding]; other site 596153010612 substrate interface [chemical binding]; other site 596153010613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153010614 Response regulator receiver domain; Region: Response_reg; pfam00072 596153010615 active site 596153010616 phosphorylation site [posttranslational modification] 596153010617 intermolecular recognition site; other site 596153010618 dimerization interface [polypeptide binding]; other site 596153010619 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 596153010620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153010621 active site 596153010622 phosphorylation site [posttranslational modification] 596153010623 intermolecular recognition site; other site 596153010624 dimerization interface [polypeptide binding]; other site 596153010625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 596153010626 DNA binding residues [nucleotide binding] 596153010627 dimerization interface [polypeptide binding]; other site 596153010628 CHASE3 domain; Region: CHASE3; pfam05227 596153010629 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 596153010630 Histidine kinase; Region: HisKA_3; pfam07730 596153010631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153010632 ATP binding site [chemical binding]; other site 596153010633 Mg2+ binding site [ion binding]; other site 596153010634 G-X-G motif; other site 596153010635 BON domain; Region: BON; pfam04972 596153010636 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 596153010637 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 596153010638 active site 596153010639 (T/H)XGH motif; other site 596153010640 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 596153010641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153010642 S-adenosylmethionine binding site [chemical binding]; other site 596153010643 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 596153010644 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 596153010645 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 596153010646 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 596153010647 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 596153010648 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 596153010649 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 596153010650 cell density-dependent motility repressor; Provisional; Region: PRK10082 596153010651 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153010652 LysR substrate binding domain; Region: LysR_substrate; pfam03466 596153010653 dimerization interface [polypeptide binding]; other site 596153010654 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 596153010655 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 596153010656 inhibitor site; inhibition site 596153010657 active site 596153010658 dimer interface [polypeptide binding]; other site 596153010659 catalytic residue [active] 596153010660 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153010661 short chain dehydrogenase; Provisional; Region: PRK07577 596153010662 classical (c) SDRs; Region: SDR_c; cd05233 596153010663 NAD(P) binding site [chemical binding]; other site 596153010664 active site 596153010665 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 596153010666 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 596153010667 putative active site pocket [active] 596153010668 metal binding site [ion binding]; metal-binding site 596153010669 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 596153010670 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153010671 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153010672 aconitate hydratase; Provisional; Region: acnA; PRK12881 596153010673 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 596153010674 substrate binding site [chemical binding]; other site 596153010675 ligand binding site [chemical binding]; other site 596153010676 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 596153010677 substrate binding site [chemical binding]; other site 596153010678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153010679 DNA-binding site [nucleotide binding]; DNA binding site 596153010680 Transcriptional regulators [Transcription]; Region: GntR; COG1802 596153010681 FCD domain; Region: FCD; pfam07729 596153010682 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 596153010683 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 596153010684 substrate binding pocket [chemical binding]; other site 596153010685 membrane-bound complex binding site; other site 596153010686 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 596153010687 6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240 596153010688 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 596153010689 putative NAD(P) binding site [chemical binding]; other site 596153010690 catalytic Zn binding site [ion binding]; other site 596153010691 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 596153010692 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 596153010693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153010694 active site 596153010695 phosphorylation site [posttranslational modification] 596153010696 intermolecular recognition site; other site 596153010697 dimerization interface [polypeptide binding]; other site 596153010698 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 596153010699 DNA binding site [nucleotide binding] 596153010700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153010701 dimer interface [polypeptide binding]; other site 596153010702 phosphorylation site [posttranslational modification] 596153010703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153010704 Mg2+ binding site [ion binding]; other site 596153010705 G-X-G motif; other site 596153010706 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 596153010707 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 596153010708 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 596153010709 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 596153010710 Protein of unknown function (DUF3240); Region: DUF3240; pfam11582 596153010711 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 596153010712 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 596153010713 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 596153010714 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 596153010715 DNA binding residues [nucleotide binding] 596153010716 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153010717 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 596153010718 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 596153010719 Cu(I) binding site [ion binding]; other site 596153010720 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 596153010721 UbiA prenyltransferase family; Region: UbiA; pfam01040 596153010722 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 596153010723 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 596153010724 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 596153010725 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 596153010726 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 596153010727 Subunit III/VIIa interface [polypeptide binding]; other site 596153010728 Phospholipid binding site [chemical binding]; other site 596153010729 Subunit I/III interface [polypeptide binding]; other site 596153010730 Subunit III/VIb interface [polypeptide binding]; other site 596153010731 Subunit III/VIa interface; other site 596153010732 Subunit III/Vb interface [polypeptide binding]; other site 596153010733 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 596153010734 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 596153010735 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 596153010736 Subunit I/III interface [polypeptide binding]; other site 596153010737 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 596153010738 D-pathway; other site 596153010739 Subunit I/VIIc interface [polypeptide binding]; other site 596153010740 Subunit I/IV interface [polypeptide binding]; other site 596153010741 Subunit I/II interface [polypeptide binding]; other site 596153010742 Low-spin heme (heme a) binding site [chemical binding]; other site 596153010743 Subunit I/VIIa interface [polypeptide binding]; other site 596153010744 Subunit I/VIa interface [polypeptide binding]; other site 596153010745 Dimer interface; other site 596153010746 Putative water exit pathway; other site 596153010747 Binuclear center (heme a3/CuB) [ion binding]; other site 596153010748 K-pathway; other site 596153010749 Subunit I/Vb interface [polypeptide binding]; other site 596153010750 Putative proton exit pathway; other site 596153010751 Subunit I/VIb interface; other site 596153010752 Subunit I/VIc interface [polypeptide binding]; other site 596153010753 Electron transfer pathway; other site 596153010754 Subunit I/VIIIb interface [polypeptide binding]; other site 596153010755 Subunit I/VIIb interface [polypeptide binding]; other site 596153010756 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 596153010757 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 596153010758 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 596153010759 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 596153010760 Cytochrome c; Region: Cytochrom_C; pfam00034 596153010761 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 596153010762 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 596153010763 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 596153010764 active site 596153010765 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 596153010766 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153010767 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153010768 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 596153010769 putative effector binding pocket; other site 596153010770 dimerization interface [polypeptide binding]; other site 596153010771 ParA-like protein; Provisional; Region: PHA02518 596153010772 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 596153010773 P-loop; other site 596153010774 Magnesium ion binding site [ion binding]; other site 596153010775 LysE type translocator; Region: LysE; cl00565 596153010776 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 596153010777 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 596153010778 TrkA-N domain; Region: TrkA_N; pfam02254 596153010779 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 596153010780 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153010781 DNA-binding site [nucleotide binding]; DNA binding site 596153010782 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 596153010783 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 596153010784 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 596153010785 tetramer interface [polypeptide binding]; other site 596153010786 active site 596153010787 Mg2+/Mn2+ binding site [ion binding]; other site 596153010788 isopropylmalate isomerase large subunit; Provisional; Region: PRK12466 596153010789 substrate binding site [chemical binding]; other site 596153010790 ligand binding site [chemical binding]; other site 596153010791 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 596153010792 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 596153010793 hypothetical protein; Provisional; Region: PRK14812 596153010794 substrate binding site [chemical binding]; other site 596153010795 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153010796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 596153010797 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 596153010798 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153010799 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153010800 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 596153010801 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 596153010802 metal binding site [ion binding]; metal-binding site 596153010803 putative dimer interface [polypeptide binding]; other site 596153010804 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153010805 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153010806 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 596153010807 putative substrate binding pocket [chemical binding]; other site 596153010808 putative dimerization interface [polypeptide binding]; other site 596153010809 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153010810 short chain dehydrogenase; Provisional; Region: PRK07577 596153010811 classical (c) SDRs; Region: SDR_c; cd05233 596153010812 NAD(P) binding site [chemical binding]; other site 596153010813 active site 596153010814 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 596153010815 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 596153010816 dimer interface [polypeptide binding]; other site 596153010817 active site 596153010818 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 596153010819 Coenzyme A transferase; Region: CoA_trans; cl17247 596153010820 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 596153010821 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 596153010822 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153010823 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 596153010824 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 596153010825 Ligand Binding Site [chemical binding]; other site 596153010826 Cytochrome c553 [Energy production and conversion]; Region: COG2863 596153010827 Cytochrome c; Region: Cytochrom_C; cl11414 596153010828 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 596153010829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153010830 Walker A motif; other site 596153010831 ATP binding site [chemical binding]; other site 596153010832 Walker B motif; other site 596153010833 arginine finger; other site 596153010834 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 596153010835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153010836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153010837 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 596153010838 DNA-binding site [nucleotide binding]; DNA binding site 596153010839 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 596153010840 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153010841 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153010842 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153010843 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153010844 active site 596153010845 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 596153010846 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153010847 substrate binding site [chemical binding]; other site 596153010848 oxyanion hole (OAH) forming residues; other site 596153010849 trimer interface [polypeptide binding]; other site 596153010850 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 596153010851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 596153010852 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 596153010853 Surface antigen; Region: Bac_surface_Ag; pfam01103 596153010854 Family of unknown function (DUF490); Region: DUF490; pfam04357 596153010855 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 596153010856 Predicted chitinase [General function prediction only]; Region: COG3179 596153010857 catalytic residue [active] 596153010858 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 596153010859 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 596153010860 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 596153010861 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 596153010862 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 596153010863 oligomer interface [polypeptide binding]; other site 596153010864 tandem repeat interface [polypeptide binding]; other site 596153010865 active site residues [active] 596153010866 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 596153010867 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 596153010868 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 596153010869 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 596153010870 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 596153010871 GIY-YIG motif/motif A; other site 596153010872 active site 596153010873 catalytic site [active] 596153010874 metal binding site [ion binding]; metal-binding site 596153010875 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 596153010876 ParB-like nuclease domain; Region: ParB; smart00470 596153010877 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 596153010878 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 596153010879 HD domain; Region: HD_3; cl17350 596153010880 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 596153010881 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 596153010882 putative active site [active] 596153010883 putative NTP binding site [chemical binding]; other site 596153010884 putative nucleic acid binding site [nucleotide binding]; other site 596153010885 Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505 596153010886 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 596153010887 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 596153010888 cofactor binding site; other site 596153010889 DNA binding site [nucleotide binding] 596153010890 substrate interaction site [chemical binding]; other site 596153010891 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 596153010892 Helix-turn-helix domain; Region: HTH_17; cl17695 596153010893 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 596153010894 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 596153010895 active site 596153010896 DNA binding site [nucleotide binding] 596153010897 Int/Topo IB signature motif; other site 596153010898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 596153010899 non-specific DNA binding site [nucleotide binding]; other site 596153010900 salt bridge; other site 596153010901 sequence-specific DNA binding site [nucleotide binding]; other site 596153010902 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 596153010903 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 596153010904 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 596153010905 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 596153010906 active site 596153010907 DNA binding site [nucleotide binding] 596153010908 Int/Topo IB signature motif; other site 596153010909 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 596153010910 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 596153010911 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 596153010912 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 596153010913 Low-spin heme binding site [chemical binding]; other site 596153010914 D-pathway; other site 596153010915 Putative water exit pathway; other site 596153010916 Binuclear center (active site) [active] 596153010917 K-pathway; other site 596153010918 Putative proton exit pathway; other site 596153010919 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 596153010920 UbiA prenyltransferase family; Region: UbiA; pfam01040 596153010921 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 596153010922 Cu(I) binding site [ion binding]; other site 596153010923 intrachain domain interface; other site 596153010924 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 596153010925 heme bH binding site [chemical binding]; other site 596153010926 Qo binding site; other site 596153010927 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 596153010928 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 596153010929 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 596153010930 heme bH binding site [chemical binding]; other site 596153010931 intrachain domain interface; other site 596153010932 heme bL binding site [chemical binding]; other site 596153010933 interchain domain interface [polypeptide binding]; other site 596153010934 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 596153010935 Qo binding site; other site 596153010936 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 596153010937 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 596153010938 catalytic loop [active] 596153010939 iron binding site [ion binding]; other site 596153010940 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 596153010941 FAD binding pocket [chemical binding]; other site 596153010942 FAD binding motif [chemical binding]; other site 596153010943 phosphate binding motif [ion binding]; other site 596153010944 beta-alpha-beta structure motif; other site 596153010945 NAD binding pocket [chemical binding]; other site 596153010946 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 596153010947 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 596153010948 putative active site [active] 596153010949 catalytic site [active] 596153010950 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 596153010951 putative active site [active] 596153010952 catalytic site [active] 596153010953 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153010954 dimer interface [polypeptide binding]; other site 596153010955 phosphorylation site [posttranslational modification] 596153010956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153010957 ATP binding site [chemical binding]; other site 596153010958 Mg2+ binding site [ion binding]; other site 596153010959 G-X-G motif; other site 596153010960 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 596153010961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153010962 active site 596153010963 phosphorylation site [posttranslational modification] 596153010964 intermolecular recognition site; other site 596153010965 dimerization interface [polypeptide binding]; other site 596153010966 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 596153010967 DNA binding site [nucleotide binding] 596153010968 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 596153010969 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 596153010970 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 596153010971 protein binding site [polypeptide binding]; other site 596153010972 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 596153010973 protein binding site [polypeptide binding]; other site 596153010974 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 596153010975 ArsC family; Region: ArsC; pfam03960 596153010976 catalytic residues [active] 596153010977 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 596153010978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153010979 dimer interface [polypeptide binding]; other site 596153010980 conserved gate region; other site 596153010981 putative PBP binding loops; other site 596153010982 ABC-ATPase subunit interface; other site 596153010983 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 596153010984 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 596153010985 Walker A/P-loop; other site 596153010986 ATP binding site [chemical binding]; other site 596153010987 Q-loop/lid; other site 596153010988 ABC transporter signature motif; other site 596153010989 Walker B; other site 596153010990 D-loop; other site 596153010991 H-loop/switch region; other site 596153010992 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 596153010993 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 596153010994 putative acyl-acceptor binding pocket; other site 596153010995 dihydroorotase; Provisional; Region: PRK07627 596153010996 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 596153010997 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 596153010998 active site 596153010999 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 596153011000 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 596153011001 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 596153011002 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 596153011003 active site 596153011004 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 596153011005 hypothetical protein; Validated; Region: PRK00228 596153011006 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 596153011007 putative binding surface; other site 596153011008 active site 596153011009 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 596153011010 putative binding surface; other site 596153011011 active site 596153011012 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 596153011013 putative binding surface; other site 596153011014 active site 596153011015 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 596153011016 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 596153011017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153011018 ATP binding site [chemical binding]; other site 596153011019 Mg2+ binding site [ion binding]; other site 596153011020 G-X-G motif; other site 596153011021 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 596153011022 Response regulator receiver domain; Region: Response_reg; pfam00072 596153011023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153011024 active site 596153011025 phosphorylation site [posttranslational modification] 596153011026 intermolecular recognition site; other site 596153011027 dimerization interface [polypeptide binding]; other site 596153011028 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 596153011029 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 596153011030 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 596153011031 dimer interface [polypeptide binding]; other site 596153011032 putative CheW interface [polypeptide binding]; other site 596153011033 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 596153011034 Response regulator receiver domain; Region: Response_reg; pfam00072 596153011035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153011036 active site 596153011037 phosphorylation site [posttranslational modification] 596153011038 intermolecular recognition site; other site 596153011039 dimerization interface [polypeptide binding]; other site 596153011040 Response regulator receiver domain; Region: Response_reg; pfam00072 596153011041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153011042 active site 596153011043 phosphorylation site [posttranslational modification] 596153011044 intermolecular recognition site; other site 596153011045 dimerization interface [polypeptide binding]; other site 596153011046 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 596153011047 Rubredoxin; Region: Rubredoxin; pfam00301 596153011048 iron binding site [ion binding]; other site 596153011049 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 596153011050 substrate binding site [chemical binding]; other site 596153011051 ATP binding site [chemical binding]; other site 596153011052 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 596153011053 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 596153011054 inhibitor-cofactor binding pocket; inhibition site 596153011055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153011056 catalytic residue [active] 596153011057 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 596153011058 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 596153011059 purine monophosphate binding site [chemical binding]; other site 596153011060 dimer interface [polypeptide binding]; other site 596153011061 putative catalytic residues [active] 596153011062 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 596153011063 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 596153011064 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 596153011065 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 596153011066 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 596153011067 FMN binding site [chemical binding]; other site 596153011068 active site 596153011069 catalytic residues [active] 596153011070 substrate binding site [chemical binding]; other site 596153011071 Predicted membrane protein [Function unknown]; Region: COG1238 596153011072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153011073 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153011074 dimerization interface [polypeptide binding]; other site 596153011075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153011076 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 596153011077 amidohydrolase; Region: amidohydrolases; TIGR01891 596153011078 putative metal binding site [ion binding]; other site 596153011079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 596153011080 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 596153011081 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 596153011082 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 596153011083 dimerization interface [polypeptide binding]; other site 596153011084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153011085 ATP binding site [chemical binding]; other site 596153011086 Mg2+ binding site [ion binding]; other site 596153011087 G-X-G motif; other site 596153011088 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 596153011089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153011090 active site 596153011091 phosphorylation site [posttranslational modification] 596153011092 intermolecular recognition site; other site 596153011093 dimerization interface [polypeptide binding]; other site 596153011094 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 596153011095 DNA binding site [nucleotide binding] 596153011096 GTP-binding protein YchF; Reviewed; Region: PRK09601 596153011097 YchF GTPase; Region: YchF; cd01900 596153011098 G1 box; other site 596153011099 GTP/Mg2+ binding site [chemical binding]; other site 596153011100 Switch I region; other site 596153011101 G2 box; other site 596153011102 Switch II region; other site 596153011103 G3 box; other site 596153011104 G4 box; other site 596153011105 G5 box; other site 596153011106 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 596153011107 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 596153011108 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 596153011109 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 596153011110 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 596153011111 dimerization domain [polypeptide binding]; other site 596153011112 dimer interface [polypeptide binding]; other site 596153011113 catalytic residues [active] 596153011114 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 596153011115 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 596153011116 enoyl-CoA hydratase; Provisional; Region: PRK05862 596153011117 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153011118 substrate binding site [chemical binding]; other site 596153011119 oxyanion hole (OAH) forming residues; other site 596153011120 trimer interface [polypeptide binding]; other site 596153011121 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 596153011122 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 596153011123 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 596153011124 FeS/SAM binding site; other site 596153011125 TRAM domain; Region: TRAM; pfam01938 596153011126 signal recognition particle protein; Provisional; Region: PRK10867 596153011127 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 596153011128 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 596153011129 GTP binding site [chemical binding]; other site 596153011130 Signal peptide binding domain; Region: SRP_SPB; pfam02978 596153011131 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 596153011132 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 596153011133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153011134 dimer interface [polypeptide binding]; other site 596153011135 phosphorylation site [posttranslational modification] 596153011136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153011137 ATP binding site [chemical binding]; other site 596153011138 Mg2+ binding site [ion binding]; other site 596153011139 G-X-G motif; other site 596153011140 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 596153011141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153011142 active site 596153011143 phosphorylation site [posttranslational modification] 596153011144 intermolecular recognition site; other site 596153011145 dimerization interface [polypeptide binding]; other site 596153011146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153011147 Walker A motif; other site 596153011148 ATP binding site [chemical binding]; other site 596153011149 Walker B motif; other site 596153011150 arginine finger; other site 596153011151 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 596153011152 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 596153011153 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 596153011154 amidase catalytic site [active] 596153011155 Zn binding residues [ion binding]; other site 596153011156 substrate binding site [chemical binding]; other site 596153011157 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 596153011158 ATP cone domain; Region: ATP-cone; pfam03477 596153011159 Class I ribonucleotide reductase; Region: RNR_I; cd01679 596153011160 active site 596153011161 dimer interface [polypeptide binding]; other site 596153011162 catalytic residues [active] 596153011163 effector binding site; other site 596153011164 R2 peptide binding site; other site 596153011165 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 596153011166 dimer interface [polypeptide binding]; other site 596153011167 putative radical transfer pathway; other site 596153011168 diiron center [ion binding]; other site 596153011169 tyrosyl radical; other site 596153011170 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 596153011171 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 596153011172 substrate binding site [chemical binding]; other site 596153011173 ATP binding site [chemical binding]; other site 596153011174 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 596153011175 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 596153011176 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 596153011177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 596153011178 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 596153011179 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 596153011180 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 596153011181 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 596153011182 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 596153011183 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 596153011184 carboxyltransferase (CT) interaction site; other site 596153011185 biotinylation site [posttranslational modification]; other site 596153011186 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 596153011187 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 596153011188 catalytic residues [active] 596153011189 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 596153011190 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 596153011191 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 596153011192 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 596153011193 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 596153011194 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 596153011195 protease TldD; Provisional; Region: tldD; PRK10735 596153011196 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 596153011197 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 596153011198 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 596153011199 O-Antigen ligase; Region: Wzy_C; pfam04932 596153011200 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 596153011201 Cytochrome c; Region: Cytochrom_C; cl11414 596153011202 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 596153011203 dinuclear metal binding motif [ion binding]; other site 596153011204 RNA polymerase sigma factor; Provisional; Region: PRK11922 596153011205 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 596153011206 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 596153011207 DNA binding residues [nucleotide binding] 596153011208 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 596153011209 RNB domain; Region: RNB; pfam00773 596153011210 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 596153011211 TonB C terminal; Region: TonB_2; pfam13103 596153011212 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 596153011213 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 596153011214 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 596153011215 shikimate binding site; other site 596153011216 NAD(P) binding site [chemical binding]; other site 596153011217 Transglycosylase; Region: Transgly; cl17702 596153011218 putative transposase OrfB; Reviewed; Region: PHA02517 596153011219 Integrase core domain; Region: rve; pfam00665 596153011220 Integrase core domain; Region: rve_3; pfam13683 596153011221 Transposase; Region: HTH_Tnp_1; pfam01527 596153011222 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 596153011223 active site 596153011224 putative DNA-binding cleft [nucleotide binding]; other site 596153011225 dimer interface [polypeptide binding]; other site 596153011226 Predicted transcriptional regulators [Transcription]; Region: COG1733 596153011227 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 596153011228 Methyltransferase domain; Region: Methyltransf_11; pfam08241 596153011229 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 596153011230 ThiC-associated domain; Region: ThiC-associated; pfam13667 596153011231 ThiC family; Region: ThiC; pfam01964 596153011232 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 596153011233 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 596153011234 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153011235 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 596153011236 Putative cyclase; Region: Cyclase; cl00814 596153011237 acyl-CoA synthetase; Validated; Region: PRK06164 596153011238 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153011239 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153011240 acyl-activating enzyme (AAE) consensus motif; other site 596153011241 acyl-activating enzyme (AAE) consensus motif; other site 596153011242 AMP binding site [chemical binding]; other site 596153011243 active site 596153011244 CoA binding site [chemical binding]; other site 596153011245 short chain dehydrogenase; Provisional; Region: PRK07577 596153011246 classical (c) SDRs; Region: SDR_c; cd05233 596153011247 NAD(P) binding site [chemical binding]; other site 596153011248 active site 596153011249 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153011250 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 596153011251 putative ligand binding site [chemical binding]; other site 596153011252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153011253 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153011254 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153011255 active site 596153011256 cell division protein FtsZ; Validated; Region: PRK09330 596153011257 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 596153011258 nucleotide binding site [chemical binding]; other site 596153011259 SulA interaction site; other site 596153011260 cell division protein FtsA; Region: ftsA; TIGR01174 596153011261 Cell division protein FtsA; Region: FtsA; smart00842 596153011262 Cell division protein FtsA; Region: FtsA; pfam14450 596153011263 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 596153011264 Cell division protein FtsQ; Region: FtsQ; pfam03799 596153011265 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 596153011266 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 596153011267 ATP-grasp domain; Region: ATP-grasp_4; cl17255 596153011268 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 596153011269 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 596153011270 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 596153011271 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 596153011272 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 596153011273 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 596153011274 active site 596153011275 homodimer interface [polypeptide binding]; other site 596153011276 cell division protein FtsW; Region: ftsW; TIGR02614 596153011277 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 596153011278 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 596153011279 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 596153011280 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 596153011281 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 596153011282 Mg++ binding site [ion binding]; other site 596153011283 putative catalytic motif [active] 596153011284 putative substrate binding site [chemical binding]; other site 596153011285 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 596153011286 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 596153011287 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 596153011288 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 596153011289 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 596153011290 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 596153011291 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 596153011292 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 596153011293 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 596153011294 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 596153011295 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 596153011296 Cell division protein FtsL; Region: FtsL; pfam04999 596153011297 MraW methylase family; Region: Methyltransf_5; cl17771 596153011298 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 596153011299 cell division protein MraZ; Reviewed; Region: PRK00326 596153011300 MraZ protein; Region: MraZ; pfam02381 596153011301 MraZ protein; Region: MraZ; pfam02381 596153011302 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 596153011303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153011304 Walker A motif; other site 596153011305 ATP binding site [chemical binding]; other site 596153011306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153011307 Walker B motif; other site 596153011308 arginine finger; other site 596153011309 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 596153011310 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 596153011311 active site 596153011312 HslU subunit interaction site [polypeptide binding]; other site 596153011313 STAS domain; Region: STAS_2; pfam13466 596153011314 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 596153011315 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 596153011316 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 596153011317 P-loop, Walker A motif; other site 596153011318 Base recognition motif; other site 596153011319 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 596153011320 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 596153011321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153011322 active site 596153011323 phosphorylation site [posttranslational modification] 596153011324 intermolecular recognition site; other site 596153011325 dimerization interface [polypeptide binding]; other site 596153011326 Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534 596153011327 Helix-turn-helix domain; Region: HTH_17; pfam12728 596153011328 Response regulator receiver domain; Region: Response_reg; pfam00072 596153011329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153011330 active site 596153011331 phosphorylation site [posttranslational modification] 596153011332 intermolecular recognition site; other site 596153011333 dimerization interface [polypeptide binding]; other site 596153011334 Response regulator receiver domain; Region: Response_reg; pfam00072 596153011335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153011336 active site 596153011337 phosphorylation site [posttranslational modification] 596153011338 intermolecular recognition site; other site 596153011339 dimerization interface [polypeptide binding]; other site 596153011340 Helix-turn-helix domain; Region: HTH_17; pfam12728 596153011341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153011342 active site 596153011343 phosphorylation site [posttranslational modification] 596153011344 intermolecular recognition site; other site 596153011345 Response regulator receiver domain; Region: Response_reg; pfam00072 596153011346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153011347 active site 596153011348 phosphorylation site [posttranslational modification] 596153011349 intermolecular recognition site; other site 596153011350 dimerization interface [polypeptide binding]; other site 596153011351 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 596153011352 Zn2+ binding site [ion binding]; other site 596153011353 Mg2+ binding site [ion binding]; other site 596153011354 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153011355 PAS domain; Region: PAS_9; pfam13426 596153011356 putative active site [active] 596153011357 heme pocket [chemical binding]; other site 596153011358 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 596153011359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153011360 dimer interface [polypeptide binding]; other site 596153011361 phosphorylation site [posttranslational modification] 596153011362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153011363 ATP binding site [chemical binding]; other site 596153011364 Mg2+ binding site [ion binding]; other site 596153011365 G-X-G motif; other site 596153011366 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 596153011367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153011368 dimer interface [polypeptide binding]; other site 596153011369 phosphorylation site [posttranslational modification] 596153011370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153011371 ATP binding site [chemical binding]; other site 596153011372 Mg2+ binding site [ion binding]; other site 596153011373 G-X-G motif; other site 596153011374 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 596153011375 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 596153011376 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 596153011377 dimerization interface [polypeptide binding]; other site 596153011378 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 596153011379 dimer interface [polypeptide binding]; other site 596153011380 putative CheW interface [polypeptide binding]; other site 596153011381 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 596153011382 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 596153011383 active site 596153011384 DNA binding site [nucleotide binding] 596153011385 Int/Topo IB signature motif; other site 596153011386 Protein of unknown function, DUF484; Region: DUF484; cl17449 596153011387 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 596153011388 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 596153011389 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 596153011390 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 596153011391 nudix motif; other site 596153011392 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 596153011393 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 596153011394 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 596153011395 RNA binding surface [nucleotide binding]; other site 596153011396 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 596153011397 active site 596153011398 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 596153011399 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 596153011400 dimer interface [polypeptide binding]; other site 596153011401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153011402 catalytic residue [active] 596153011403 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 596153011404 HSP70 interaction site [polypeptide binding]; other site 596153011405 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 596153011406 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 596153011407 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153011408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153011409 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 596153011410 putative dimerization interface [polypeptide binding]; other site 596153011411 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 596153011412 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153011413 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153011414 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153011415 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 596153011416 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 596153011417 active site 596153011418 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153011419 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 596153011420 MarR family; Region: MarR_2; pfam12802 596153011421 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 596153011422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153011423 NAD(P) binding site [chemical binding]; other site 596153011424 active site 596153011425 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153011426 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 596153011427 substrate binding site [chemical binding]; other site 596153011428 oxyanion hole (OAH) forming residues; other site 596153011429 trimer interface [polypeptide binding]; other site 596153011430 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 596153011431 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153011432 active site 596153011433 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 596153011434 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 596153011435 acyl-activating enzyme (AAE) consensus motif; other site 596153011436 putative AMP binding site [chemical binding]; other site 596153011437 putative active site [active] 596153011438 putative CoA binding site [chemical binding]; other site 596153011439 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 596153011440 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 596153011441 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 596153011442 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 596153011443 Ligand binding site [chemical binding]; other site 596153011444 Electron transfer flavoprotein domain; Region: ETF; pfam01012 596153011445 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 596153011446 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 596153011447 FMN binding site [chemical binding]; other site 596153011448 substrate binding site [chemical binding]; other site 596153011449 putative catalytic residue [active] 596153011450 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153011451 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153011452 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153011453 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 596153011454 CoenzymeA binding site [chemical binding]; other site 596153011455 subunit interaction site [polypeptide binding]; other site 596153011456 PHB binding site; other site 596153011457 enoyl-CoA hydratase; Provisional; Region: PRK07511 596153011458 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153011459 substrate binding site [chemical binding]; other site 596153011460 oxyanion hole (OAH) forming residues; other site 596153011461 trimer interface [polypeptide binding]; other site 596153011462 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 596153011463 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 596153011464 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 596153011465 active site 596153011466 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 596153011467 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153011468 active site 596153011469 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 596153011470 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 596153011471 dimer interface [polypeptide binding]; other site 596153011472 active site 596153011473 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 596153011474 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153011475 substrate binding site [chemical binding]; other site 596153011476 oxyanion hole (OAH) forming residues; other site 596153011477 trimer interface [polypeptide binding]; other site 596153011478 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 596153011479 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 596153011480 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 596153011481 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153011482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153011483 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 596153011484 putative effector binding pocket; other site 596153011485 dimerization interface [polypeptide binding]; other site 596153011486 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 596153011487 Transposase; Region: HTH_Tnp_1; cl17663 596153011488 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153011489 putative transposase OrfB; Reviewed; Region: PHA02517 596153011490 HTH-like domain; Region: HTH_21; pfam13276 596153011491 Integrase core domain; Region: rve; pfam00665 596153011492 Integrase core domain; Region: rve_3; cl15866 596153011493 putative transposase OrfB; Reviewed; Region: PHA02517 596153011494 Integrase core domain; Region: rve; pfam00665 596153011495 Integrase core domain; Region: rve_3; pfam13683 596153011496 Transposase; Region: HTH_Tnp_1; pfam01527 596153011497 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 596153011498 active site 596153011499 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 596153011500 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 596153011501 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 596153011502 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 596153011503 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 596153011504 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 596153011505 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 596153011506 Transposase; Region: HTH_Tnp_1; pfam01527 596153011507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153011508 heat shock protein HtpX; Provisional; Region: PRK05457 596153011509 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 596153011510 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 596153011511 active site 596153011512 substrate binding pocket [chemical binding]; other site 596153011513 dimer interface [polypeptide binding]; other site 596153011514 Uncharacterized conserved protein [Function unknown]; Region: COG3189 596153011515 Uncharacterized conserved protein [Function unknown]; Region: COG2128 596153011516 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 596153011517 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 596153011518 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 596153011519 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 596153011520 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 596153011521 excinuclease ABC, A subunit; Region: uvra; TIGR00630 596153011522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 596153011523 Walker A/P-loop; other site 596153011524 ATP binding site [chemical binding]; other site 596153011525 Q-loop/lid; other site 596153011526 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 596153011527 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 596153011528 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 596153011529 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 596153011530 putative ligand binding site [chemical binding]; other site 596153011531 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 596153011532 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 596153011533 trimer interface [polypeptide binding]; other site 596153011534 eyelet of channel; other site 596153011535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153011536 putative substrate translocation pore; other site 596153011537 Protein of unknown function, DUF485; Region: DUF485; pfam04341 596153011538 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 596153011539 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 596153011540 Na binding site [ion binding]; other site 596153011541 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 596153011542 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 596153011543 active site 596153011544 catalytic site [active] 596153011545 substrate binding site [chemical binding]; other site 596153011546 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 596153011547 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 596153011548 ligand binding site [chemical binding]; other site 596153011549 flexible hinge region; other site 596153011550 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 596153011551 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 596153011552 metal binding triad; other site 596153011553 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 596153011554 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 596153011555 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 596153011556 putative deacylase active site [active] 596153011557 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 596153011558 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 596153011559 active site 596153011560 catalytic residues [active] 596153011561 metal binding site [ion binding]; metal-binding site 596153011562 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 596153011563 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 596153011564 putative ligand binding site [chemical binding]; other site 596153011565 NAD binding site [chemical binding]; other site 596153011566 dimerization interface [polypeptide binding]; other site 596153011567 catalytic site [active] 596153011568 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 596153011569 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 596153011570 ATP-grasp domain; Region: ATP-grasp_4; cl17255 596153011571 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 596153011572 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 596153011573 carboxyltransferase (CT) interaction site; other site 596153011574 biotinylation site [posttranslational modification]; other site 596153011575 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 596153011576 enoyl-CoA hydratase; Provisional; Region: PRK05995 596153011577 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153011578 substrate binding site [chemical binding]; other site 596153011579 oxyanion hole (OAH) forming residues; other site 596153011580 trimer interface [polypeptide binding]; other site 596153011581 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 596153011582 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 596153011583 AMP-binding domain protein; Validated; Region: PRK08315 596153011584 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153011585 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 596153011586 acyl-activating enzyme (AAE) consensus motif; other site 596153011587 putative AMP binding site [chemical binding]; other site 596153011588 putative active site [active] 596153011589 putative CoA binding site [chemical binding]; other site 596153011590 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 596153011591 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 596153011592 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 596153011593 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 596153011594 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 596153011595 putative C-terminal domain interface [polypeptide binding]; other site 596153011596 putative GSH binding site (G-site) [chemical binding]; other site 596153011597 putative dimer interface [polypeptide binding]; other site 596153011598 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 596153011599 N-terminal domain interface [polypeptide binding]; other site 596153011600 dimer interface [polypeptide binding]; other site 596153011601 substrate binding pocket (H-site) [chemical binding]; other site 596153011602 choline dehydrogenase; Validated; Region: PRK02106 596153011603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 596153011604 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 596153011605 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 596153011606 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 596153011607 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 596153011608 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 596153011609 TM-ABC transporter signature motif; other site 596153011610 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 596153011611 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 596153011612 TM-ABC transporter signature motif; other site 596153011613 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 596153011614 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 596153011615 Walker A/P-loop; other site 596153011616 ATP binding site [chemical binding]; other site 596153011617 Q-loop/lid; other site 596153011618 ABC transporter signature motif; other site 596153011619 Walker B; other site 596153011620 D-loop; other site 596153011621 H-loop/switch region; other site 596153011622 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 596153011623 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 596153011624 Walker A/P-loop; other site 596153011625 ATP binding site [chemical binding]; other site 596153011626 Q-loop/lid; other site 596153011627 ABC transporter signature motif; other site 596153011628 Walker B; other site 596153011629 D-loop; other site 596153011630 H-loop/switch region; other site 596153011631 choline dehydrogenase; Validated; Region: PRK02106 596153011632 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 596153011633 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 596153011634 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 596153011635 acyl-activating enzyme (AAE) consensus motif; other site 596153011636 putative AMP binding site [chemical binding]; other site 596153011637 putative active site [active] 596153011638 putative CoA binding site [chemical binding]; other site 596153011639 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 596153011640 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153011641 DNA-binding site [nucleotide binding]; DNA binding site 596153011642 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 596153011643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153011644 homodimer interface [polypeptide binding]; other site 596153011645 catalytic residue [active] 596153011646 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 596153011647 homodimer interface [polypeptide binding]; other site 596153011648 catalytic residues [active] 596153011649 NAD binding site [chemical binding]; other site 596153011650 substrate binding pocket [chemical binding]; other site 596153011651 flexible flap; other site 596153011652 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 596153011653 PAS fold; Region: PAS; pfam00989 596153011654 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 596153011655 putative active site [active] 596153011656 heme pocket [chemical binding]; other site 596153011657 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153011658 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153011659 metal binding site [ion binding]; metal-binding site 596153011660 active site 596153011661 I-site; other site 596153011662 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 596153011663 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 596153011664 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 596153011665 PAS domain; Region: PAS_9; pfam13426 596153011666 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153011667 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153011668 metal binding site [ion binding]; metal-binding site 596153011669 active site 596153011670 I-site; other site 596153011671 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 596153011672 hypothetical protein; Provisional; Region: PRK01842 596153011673 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 596153011674 Predicted membrane protein [Function unknown]; Region: COG2323 596153011675 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153011676 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 596153011677 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153011678 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 596153011679 active site pocket [active] 596153011680 oxyanion hole [active] 596153011681 catalytic triad [active] 596153011682 active site nucleophile [active] 596153011683 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 596153011684 AroM protein; Region: AroM; cl17601 596153011685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153011686 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153011687 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153011688 active site 596153011689 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 596153011690 C factor cell-cell signaling protein; Provisional; Region: PRK09009 596153011691 NADP binding site [chemical binding]; other site 596153011692 homodimer interface [polypeptide binding]; other site 596153011693 active site 596153011694 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 596153011695 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 596153011696 dimer interface [polypeptide binding]; other site 596153011697 active site 596153011698 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 596153011699 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 596153011700 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 596153011701 active site clefts [active] 596153011702 zinc binding site [ion binding]; other site 596153011703 dimer interface [polypeptide binding]; other site 596153011704 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 596153011705 isovaleryl-CoA dehydrogenase; Region: PLN02519 596153011706 substrate binding site [chemical binding]; other site 596153011707 FAD binding site [chemical binding]; other site 596153011708 catalytic base [active] 596153011709 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 596153011710 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 596153011711 DNA binding residues [nucleotide binding] 596153011712 putative dimer interface [polypeptide binding]; other site 596153011713 ABC transporter ATPase component; Reviewed; Region: PRK11147 596153011714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 596153011715 Walker A/P-loop; other site 596153011716 ATP binding site [chemical binding]; other site 596153011717 Q-loop/lid; other site 596153011718 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 596153011719 ABC transporter signature motif; other site 596153011720 Walker B; other site 596153011721 ABC transporter; Region: ABC_tran_2; pfam12848 596153011722 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 596153011723 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 596153011724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153011725 active site 596153011726 phosphorylation site [posttranslational modification] 596153011727 intermolecular recognition site; other site 596153011728 dimerization interface [polypeptide binding]; other site 596153011729 CheB methylesterase; Region: CheB_methylest; pfam01339 596153011730 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487 596153011731 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 596153011732 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 596153011733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153011734 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 596153011735 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 596153011736 putative binding surface; other site 596153011737 active site 596153011738 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 596153011739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153011740 ATP binding site [chemical binding]; other site 596153011741 Mg2+ binding site [ion binding]; other site 596153011742 G-X-G motif; other site 596153011743 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 596153011744 Response regulator receiver domain; Region: Response_reg; pfam00072 596153011745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153011746 active site 596153011747 phosphorylation site [posttranslational modification] 596153011748 intermolecular recognition site; other site 596153011749 dimerization interface [polypeptide binding]; other site 596153011750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153011751 Response regulator receiver domain; Region: Response_reg; pfam00072 596153011752 active site 596153011753 phosphorylation site [posttranslational modification] 596153011754 intermolecular recognition site; other site 596153011755 dimerization interface [polypeptide binding]; other site 596153011756 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 596153011757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153011758 ATP binding site [chemical binding]; other site 596153011759 Mg2+ binding site [ion binding]; other site 596153011760 G-X-G motif; other site 596153011761 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 596153011762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153011763 active site 596153011764 phosphorylation site [posttranslational modification] 596153011765 intermolecular recognition site; other site 596153011766 dimerization interface [polypeptide binding]; other site 596153011767 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 596153011768 DNA binding residues [nucleotide binding] 596153011769 dimerization interface [polypeptide binding]; other site 596153011770 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 596153011771 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 596153011772 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 596153011773 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 596153011774 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 596153011775 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 596153011776 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 596153011777 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 596153011778 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 596153011779 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 596153011780 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 596153011781 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 596153011782 Walker A motif/ATP binding site; other site 596153011783 Walker B motif; other site 596153011784 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 596153011785 Flagellar assembly protein FliH; Region: FliH; pfam02108 596153011786 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 596153011787 MgtE intracellular N domain; Region: MgtE_N; cl15244 596153011788 FliG C-terminal domain; Region: FliG_C; pfam01706 596153011789 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 596153011790 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 596153011791 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 596153011792 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 596153011793 Flagellar protein FliT; Region: FliT; pfam05400 596153011794 Flagellar protein FliS; Region: FliS; cl00654 596153011795 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 596153011796 flagellar capping protein; Reviewed; Region: fliD; PRK08032 596153011797 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 596153011798 flagellin; Reviewed; Region: PRK08869 596153011799 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 596153011800 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 596153011801 flagellin; Reviewed; Region: PRK08869 596153011802 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 596153011803 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 596153011804 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 596153011805 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 596153011806 putative ligand binding site [chemical binding]; other site 596153011807 putative catalytic site [active] 596153011808 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 596153011809 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 596153011810 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 596153011811 Probable Catalytic site; other site 596153011812 metal-binding site 596153011813 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 596153011814 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 596153011815 active site 596153011816 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 596153011817 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 596153011818 flagellar motor protein MotA; Validated; Region: PRK09110 596153011819 flagellar motor protein MotB; Validated; Region: motB; PRK09041 596153011820 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 596153011821 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 596153011822 ligand binding site [chemical binding]; other site 596153011823 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 596153011824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153011825 active site 596153011826 phosphorylation site [posttranslational modification] 596153011827 intermolecular recognition site; other site 596153011828 dimerization interface [polypeptide binding]; other site 596153011829 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 596153011830 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 596153011831 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 596153011832 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 596153011833 FHIPEP family; Region: FHIPEP; pfam00771 596153011834 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995 596153011835 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 596153011836 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 596153011837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 596153011838 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 596153011839 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 596153011840 DNA binding residues [nucleotide binding] 596153011841 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 596153011842 SAF-like; Region: SAF_2; pfam13144 596153011843 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 596153011844 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 596153011845 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 596153011846 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 596153011847 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 596153011848 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 596153011849 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 596153011850 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 596153011851 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 596153011852 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 596153011853 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 596153011854 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 596153011855 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 596153011856 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 596153011857 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 596153011858 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 596153011859 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 596153011860 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 596153011861 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 596153011862 Flagellar L-ring protein; Region: FlgH; pfam02107 596153011863 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 596153011864 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 596153011865 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 596153011866 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 596153011867 Rod binding protein; Region: Rod-binding; cl01626 596153011868 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 596153011869 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 596153011870 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 596153011871 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 596153011872 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 596153011873 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 596153011874 Nitronate monooxygenase; Region: NMO; pfam03060 596153011875 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 596153011876 FMN binding site [chemical binding]; other site 596153011877 substrate binding site [chemical binding]; other site 596153011878 putative catalytic residue [active] 596153011879 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 596153011880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153011881 DNA-binding site [nucleotide binding]; DNA binding site 596153011882 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 596153011883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153011884 homodimer interface [polypeptide binding]; other site 596153011885 catalytic residue [active] 596153011886 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 596153011887 EamA-like transporter family; Region: EamA; pfam00892 596153011888 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 596153011889 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 596153011890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153011891 homodimer interface [polypeptide binding]; other site 596153011892 catalytic residue [active] 596153011893 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 596153011894 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 596153011895 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 596153011896 tetramer interface [polypeptide binding]; other site 596153011897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153011898 catalytic residue [active] 596153011899 Putative cyclase; Region: Cyclase; cl00814 596153011900 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153011901 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 596153011902 putative ligand binding site [chemical binding]; other site 596153011903 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 596153011904 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 596153011905 NAD(P) binding site [chemical binding]; other site 596153011906 active site 596153011907 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 596153011908 catalytic core [active] 596153011909 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153011910 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153011911 metal binding site [ion binding]; metal-binding site 596153011912 active site 596153011913 I-site; other site 596153011914 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 596153011915 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 596153011916 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 596153011917 N-terminal plug; other site 596153011918 ligand-binding site [chemical binding]; other site 596153011919 Creatinine amidohydrolase; Region: Creatininase; pfam02633 596153011920 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153011921 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 596153011922 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 596153011923 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 596153011924 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 596153011925 DsbD alpha interface [polypeptide binding]; other site 596153011926 catalytic residues [active] 596153011927 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 596153011928 putative catalytic residue [active] 596153011929 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 596153011930 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 596153011931 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 596153011932 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 596153011933 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 596153011934 substrate binding site [chemical binding]; other site 596153011935 active site 596153011936 primosome assembly protein PriA; Validated; Region: PRK05580 596153011937 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 596153011938 ATP binding site [chemical binding]; other site 596153011939 putative Mg++ binding site [ion binding]; other site 596153011940 helicase superfamily c-terminal domain; Region: HELICc; smart00490 596153011941 beta-ketothiolase; Provisional; Region: PRK09051 596153011942 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 596153011943 dimer interface [polypeptide binding]; other site 596153011944 active site 596153011945 enoyl-CoA hydratase; Provisional; Region: PRK06688 596153011946 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153011947 substrate binding site [chemical binding]; other site 596153011948 oxyanion hole (OAH) forming residues; other site 596153011949 trimer interface [polypeptide binding]; other site 596153011950 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 596153011951 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 596153011952 Walker A/P-loop; other site 596153011953 ATP binding site [chemical binding]; other site 596153011954 Q-loop/lid; other site 596153011955 ABC transporter signature motif; other site 596153011956 Walker B; other site 596153011957 D-loop; other site 596153011958 H-loop/switch region; other site 596153011959 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153011960 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 596153011961 putative ligand binding site [chemical binding]; other site 596153011962 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 596153011963 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 596153011964 TM-ABC transporter signature motif; other site 596153011965 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 596153011966 TM-ABC transporter signature motif; other site 596153011967 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 596153011968 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 596153011969 Walker A/P-loop; other site 596153011970 ATP binding site [chemical binding]; other site 596153011971 Q-loop/lid; other site 596153011972 ABC transporter signature motif; other site 596153011973 Walker B; other site 596153011974 D-loop; other site 596153011975 H-loop/switch region; other site 596153011976 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 596153011977 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 596153011978 Predicted permeases [General function prediction only]; Region: COG0679 596153011979 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 596153011980 Part of AAA domain; Region: AAA_19; pfam13245 596153011981 Family description; Region: UvrD_C_2; pfam13538 596153011982 glycogen branching enzyme; Provisional; Region: PRK05402 596153011983 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 596153011984 substrate binding site [chemical binding]; other site 596153011985 dimerization interface [polypeptide binding]; other site 596153011986 active site 596153011987 calcium binding site [ion binding]; other site 596153011988 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 596153011989 Uncharacterized conserved protein [Function unknown]; Region: COG1262 596153011990 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 596153011991 Sulfatase; Region: Sulfatase; pfam00884 596153011992 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 596153011993 active site 596153011994 metal binding site [ion binding]; metal-binding site 596153011995 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 596153011996 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 596153011997 putative active site [active] 596153011998 putative metal binding site [ion binding]; other site 596153011999 hypothetical protein; Provisional; Region: PRK06126 596153012000 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 596153012001 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 596153012002 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 596153012003 trimer interface [polypeptide binding]; other site 596153012004 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 596153012005 eyelet of channel; other site 596153012006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153012007 DNA-binding site [nucleotide binding]; DNA binding site 596153012008 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 596153012009 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 596153012010 Ligand Binding Site [chemical binding]; other site 596153012011 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 596153012012 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 596153012013 Putative zinc ribbon domain; Region: DUF164; pfam02591 596153012014 PAS domain S-box; Region: sensory_box; TIGR00229 596153012015 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153012016 putative active site [active] 596153012017 heme pocket [chemical binding]; other site 596153012018 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 596153012019 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153012020 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153012021 hypothetical protein; Validated; Region: PRK06201 596153012022 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 596153012023 Transcriptional regulators [Transcription]; Region: FadR; COG2186 596153012024 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153012025 DNA-binding site [nucleotide binding]; DNA binding site 596153012026 FCD domain; Region: FCD; pfam07729 596153012027 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 596153012028 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 596153012029 putative acyl-acceptor binding pocket; other site 596153012030 FtsH Extracellular; Region: FtsH_ext; pfam06480 596153012031 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 596153012032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153012033 Walker A motif; other site 596153012034 ATP binding site [chemical binding]; other site 596153012035 Walker B motif; other site 596153012036 arginine finger; other site 596153012037 Peptidase family M41; Region: Peptidase_M41; pfam01434 596153012038 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 596153012039 active site 596153012040 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 596153012041 active site 596153012042 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 596153012043 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 596153012044 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 596153012045 putative NAD(P) binding site [chemical binding]; other site 596153012046 putative substrate binding site [chemical binding]; other site 596153012047 catalytic Zn binding site [ion binding]; other site 596153012048 structural Zn binding site [ion binding]; other site 596153012049 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153012050 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 596153012051 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 596153012052 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 596153012053 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 596153012054 FIST N domain; Region: FIST; smart00897 596153012055 FIST C domain; Region: FIST_C; pfam10442 596153012056 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 596153012057 IHF dimer interface [polypeptide binding]; other site 596153012058 IHF - DNA interface [nucleotide binding]; other site 596153012059 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 596153012060 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 596153012061 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 596153012062 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 596153012063 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 596153012064 alphaNTD homodimer interface [polypeptide binding]; other site 596153012065 alphaNTD - beta interaction site [polypeptide binding]; other site 596153012066 alphaNTD - beta' interaction site [polypeptide binding]; other site 596153012067 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 596153012068 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 596153012069 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 596153012070 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 596153012071 RNA binding surface [nucleotide binding]; other site 596153012072 30S ribosomal protein S11; Validated; Region: PRK05309 596153012073 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 596153012074 30S ribosomal protein S13; Region: bact_S13; TIGR03631 596153012075 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 596153012076 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 596153012077 SecY translocase; Region: SecY; pfam00344 596153012078 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 596153012079 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 596153012080 23S rRNA binding site [nucleotide binding]; other site 596153012081 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 596153012082 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 596153012083 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 596153012084 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 596153012085 5S rRNA interface [nucleotide binding]; other site 596153012086 23S rRNA interface [nucleotide binding]; other site 596153012087 L5 interface [polypeptide binding]; other site 596153012088 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 596153012089 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 596153012090 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 596153012091 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 596153012092 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 596153012093 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 596153012094 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 596153012095 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 596153012096 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 596153012097 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 596153012098 RNA binding site [nucleotide binding]; other site 596153012099 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 596153012100 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 596153012101 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 596153012102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 596153012103 putative DNA binding site [nucleotide binding]; other site 596153012104 putative Zn2+ binding site [ion binding]; other site 596153012105 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 596153012106 glycerol kinase; Provisional; Region: glpK; PRK00047 596153012107 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 596153012108 N- and C-terminal domain interface [polypeptide binding]; other site 596153012109 active site 596153012110 MgATP binding site [chemical binding]; other site 596153012111 catalytic site [active] 596153012112 metal binding site [ion binding]; metal-binding site 596153012113 glycerol binding site [chemical binding]; other site 596153012114 homotetramer interface [polypeptide binding]; other site 596153012115 homodimer interface [polypeptide binding]; other site 596153012116 FBP binding site [chemical binding]; other site 596153012117 protein IIAGlc interface [polypeptide binding]; other site 596153012118 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 596153012119 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 596153012120 CotH protein; Region: CotH; pfam08757 596153012121 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 596153012122 Interdomain contacts; other site 596153012123 Cytokine receptor motif; other site 596153012124 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 596153012125 UbiA prenyltransferase family; Region: UbiA; pfam01040 596153012126 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 596153012127 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 596153012128 dimerization interface [polypeptide binding]; other site 596153012129 DPS ferroxidase diiron center [ion binding]; other site 596153012130 ion pore; other site 596153012131 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 596153012132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153012133 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 596153012134 dimerization interface [polypeptide binding]; other site 596153012135 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 596153012136 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 596153012137 generic binding surface II; other site 596153012138 ssDNA binding site; other site 596153012139 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 596153012140 ATP binding site [chemical binding]; other site 596153012141 putative Mg++ binding site [ion binding]; other site 596153012142 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 596153012143 nucleotide binding region [chemical binding]; other site 596153012144 ATP-binding site [chemical binding]; other site 596153012145 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 596153012146 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 596153012147 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 596153012148 Zn2+ binding site [ion binding]; other site 596153012149 Mg2+ binding site [ion binding]; other site 596153012150 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 596153012151 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 596153012152 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 596153012153 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 596153012154 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 596153012155 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153012156 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153012157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153012158 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153012159 dimerization interface [polypeptide binding]; other site 596153012160 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 596153012161 ligand binding site [chemical binding]; other site 596153012162 active site 596153012163 UGI interface [polypeptide binding]; other site 596153012164 catalytic site [active] 596153012165 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 596153012166 active site 596153012167 ribulose/triose binding site [chemical binding]; other site 596153012168 phosphate binding site [ion binding]; other site 596153012169 substrate (anthranilate) binding pocket [chemical binding]; other site 596153012170 product (indole) binding pocket [chemical binding]; other site 596153012171 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 596153012172 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 596153012173 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 596153012174 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 596153012175 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 596153012176 glutamine binding [chemical binding]; other site 596153012177 catalytic triad [active] 596153012178 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 596153012179 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 596153012180 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 596153012181 Magnesium ion binding site [ion binding]; other site 596153012182 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 596153012183 ParB-like nuclease domain; Region: ParBc; pfam02195 596153012184 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 596153012185 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 596153012186 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 596153012187 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 596153012188 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 596153012189 ssDNA binding site [nucleotide binding]; other site 596153012190 dimer interface [polypeptide binding]; other site 596153012191 tetramer (dimer of dimers) interface [polypeptide binding]; other site 596153012192 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 596153012193 active site 596153012194 putative interdomain interaction site [polypeptide binding]; other site 596153012195 putative metal-binding site [ion binding]; other site 596153012196 putative nucleotide binding site [chemical binding]; other site 596153012197 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 596153012198 domain I; other site 596153012199 DNA binding groove [nucleotide binding] 596153012200 phosphate binding site [ion binding]; other site 596153012201 domain III; other site 596153012202 catalytic site [active] 596153012203 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 596153012204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153012205 Walker A motif; other site 596153012206 ATP binding site [chemical binding]; other site 596153012207 Walker B motif; other site 596153012208 arginine finger; other site 596153012209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 596153012210 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 596153012211 non-specific DNA binding site [nucleotide binding]; other site 596153012212 salt bridge; other site 596153012213 sequence-specific DNA binding site [nucleotide binding]; other site 596153012214 Integrase core domain; Region: rve; pfam00665 596153012215 Methyltransferase domain; Region: Methyltransf_26; pfam13659 596153012216 S-adenosylmethionine binding site [chemical binding]; other site 596153012217 DEAD-like helicases superfamily; Region: DEXDc; smart00487 596153012218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 596153012219 nucleotide binding region [chemical binding]; other site 596153012220 ATP-binding site [chemical binding]; other site 596153012221 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 596153012222 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 596153012223 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 596153012224 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 596153012225 N-acetyl-D-glucosamine binding site [chemical binding]; other site 596153012226 catalytic residue [active] 596153012227 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 596153012228 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 596153012229 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 596153012230 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 596153012231 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 596153012232 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 596153012233 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 596153012234 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 596153012235 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 596153012236 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 596153012237 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 596153012238 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 596153012239 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 596153012240 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 596153012241 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 596153012242 ParA/MinD ATPase like; Region: ParA; pfam10609 596153012243 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 596153012244 catalytic residues [active] 596153012245 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 596153012246 MPN+ (JAMM) motif; other site 596153012247 Zinc-binding site [ion binding]; other site 596153012248 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 596153012249 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 596153012250 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 596153012251 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 596153012252 Protein of unknown function (DUF3742); Region: DUF3742; pfam12553 596153012253 RES domain; Region: RES; smart00953 596153012254 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 596153012255 Putative helicase; Region: TraI_2; pfam07514 596153012256 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 596153012257 Predicted ATPase [General function prediction only]; Region: COG3911 596153012258 AAA domain; Region: AAA_28; pfam13521 596153012259 Putative serine esterase (DUF676); Region: DUF676; pfam05057 596153012260 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 596153012261 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 596153012262 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 596153012263 non-specific DNA binding site [nucleotide binding]; other site 596153012264 salt bridge; other site 596153012265 sequence-specific DNA binding site [nucleotide binding]; other site 596153012266 Integrase core domain; Region: rve; pfam00665 596153012267 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 596153012268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153012269 Walker A motif; other site 596153012270 ATP binding site [chemical binding]; other site 596153012271 Walker B motif; other site 596153012272 arginine finger; other site 596153012273 RES domain; Region: RES; pfam08808 596153012274 Chorismate mutase type II; Region: CM_2; smart00830 596153012275 anthranilate synthase component I; Provisional; Region: PRK13565 596153012276 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 596153012277 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 596153012278 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 596153012279 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 596153012280 dimerization interface [polypeptide binding]; other site 596153012281 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 596153012282 dimer interface [polypeptide binding]; other site 596153012283 putative CheW interface [polypeptide binding]; other site 596153012284 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 596153012285 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 596153012286 dimerization interface [polypeptide binding]; other site 596153012287 PAS domain S-box; Region: sensory_box; TIGR00229 596153012288 PAS domain; Region: PAS; smart00091 596153012289 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153012290 PAS domain; Region: PAS_9; pfam13426 596153012291 putative active site [active] 596153012292 heme pocket [chemical binding]; other site 596153012293 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153012294 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153012295 metal binding site [ion binding]; metal-binding site 596153012296 active site 596153012297 I-site; other site 596153012298 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 596153012299 phosphoglycolate phosphatase; Provisional; Region: PRK13222 596153012300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 596153012301 motif II; other site 596153012302 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 596153012303 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 596153012304 substrate binding site [chemical binding]; other site 596153012305 hexamer interface [polypeptide binding]; other site 596153012306 metal binding site [ion binding]; metal-binding site 596153012307 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 596153012308 Site-specific recombinase; Region: SpecificRecomb; pfam10136 596153012309 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 596153012310 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 596153012311 thiamine monophosphate kinase; Provisional; Region: PRK05731 596153012312 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 596153012313 ATP binding site [chemical binding]; other site 596153012314 dimerization interface [polypeptide binding]; other site 596153012315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 596153012316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 596153012317 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 596153012318 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 596153012319 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 596153012320 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 596153012321 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 596153012322 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 596153012323 HlyD family secretion protein; Region: HlyD_3; pfam13437 596153012324 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 596153012325 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 596153012326 Walker A/P-loop; other site 596153012327 ATP binding site [chemical binding]; other site 596153012328 Q-loop/lid; other site 596153012329 ABC transporter signature motif; other site 596153012330 Walker B; other site 596153012331 D-loop; other site 596153012332 H-loop/switch region; other site 596153012333 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 596153012334 Walker A/P-loop; other site 596153012335 ATP binding site [chemical binding]; other site 596153012336 Q-loop/lid; other site 596153012337 ABC transporter signature motif; other site 596153012338 Walker B; other site 596153012339 D-loop; other site 596153012340 H-loop/switch region; other site 596153012341 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 596153012342 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 596153012343 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 596153012344 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 596153012345 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 596153012346 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 596153012347 dimer interaction site [polypeptide binding]; other site 596153012348 substrate-binding tunnel; other site 596153012349 active site 596153012350 catalytic site [active] 596153012351 substrate binding site [chemical binding]; other site 596153012352 phosphate acetyltransferase; Provisional; Region: PRK11890 596153012353 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 596153012354 propionate/acetate kinase; Provisional; Region: PRK12379 596153012355 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 596153012356 tetramer interfaces [polypeptide binding]; other site 596153012357 binuclear metal-binding site [ion binding]; other site 596153012358 Competence-damaged protein; Region: CinA; pfam02464 596153012359 Tar ligand binding domain homologue; Region: TarH; pfam02203 596153012360 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 596153012361 dimerization interface [polypeptide binding]; other site 596153012362 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 596153012363 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 596153012364 dimer interface [polypeptide binding]; other site 596153012365 putative CheW interface [polypeptide binding]; other site 596153012366 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 596153012367 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 596153012368 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 596153012369 dimerization interface [polypeptide binding]; other site 596153012370 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153012371 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153012372 metal binding site [ion binding]; metal-binding site 596153012373 active site 596153012374 I-site; other site 596153012375 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 596153012376 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 596153012377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153012378 active site 596153012379 phosphorylation site [posttranslational modification] 596153012380 intermolecular recognition site; other site 596153012381 dimerization interface [polypeptide binding]; other site 596153012382 ANTAR domain; Region: ANTAR; pfam03861 596153012383 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153012384 PAS domain; Region: PAS_9; pfam13426 596153012385 putative active site [active] 596153012386 heme pocket [chemical binding]; other site 596153012387 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 596153012388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 596153012389 Mg2+ binding site [ion binding]; other site 596153012390 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 596153012391 PIN domain; Region: PIN_3; pfam13470 596153012392 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 596153012393 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 596153012394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 596153012395 Cache domain; Region: Cache_1; pfam02743 596153012396 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 596153012397 dimerization interface [polypeptide binding]; other site 596153012398 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 596153012399 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 596153012400 dimer interface [polypeptide binding]; other site 596153012401 putative CheW interface [polypeptide binding]; other site 596153012402 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 596153012403 active site 596153012404 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 596153012405 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 596153012406 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 596153012407 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 596153012408 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 596153012409 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 596153012410 Walker A/P-loop; other site 596153012411 ATP binding site [chemical binding]; other site 596153012412 Q-loop/lid; other site 596153012413 ABC transporter signature motif; other site 596153012414 Walker B; other site 596153012415 D-loop; other site 596153012416 H-loop/switch region; other site 596153012417 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 596153012418 OstA-like protein; Region: OstA; pfam03968 596153012419 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 596153012420 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 596153012421 catalytic residues [active] 596153012422 hinge region; other site 596153012423 alpha helical domain; other site 596153012424 Sporulation related domain; Region: SPOR; pfam05036 596153012425 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 596153012426 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 596153012427 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 596153012428 active site 596153012429 HIGH motif; other site 596153012430 nucleotide binding site [chemical binding]; other site 596153012431 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 596153012432 KMSK motif region; other site 596153012433 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 596153012434 tRNA binding surface [nucleotide binding]; other site 596153012435 anticodon binding site; other site 596153012436 psiF repeat; Region: PsiF_repeat; pfam07769 596153012437 psiF repeat; Region: PsiF_repeat; pfam07769 596153012438 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 596153012439 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 596153012440 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 596153012441 PAS domain; Region: PAS; smart00091 596153012442 PAS fold; Region: PAS_7; pfam12860 596153012443 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 596153012444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153012445 dimer interface [polypeptide binding]; other site 596153012446 phosphorylation site [posttranslational modification] 596153012447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153012448 ATP binding site [chemical binding]; other site 596153012449 Mg2+ binding site [ion binding]; other site 596153012450 G-X-G motif; other site 596153012451 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 596153012452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153012453 active site 596153012454 phosphorylation site [posttranslational modification] 596153012455 intermolecular recognition site; other site 596153012456 dimerization interface [polypeptide binding]; other site 596153012457 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 596153012458 DNA binding residues [nucleotide binding] 596153012459 dimerization interface [polypeptide binding]; other site 596153012460 LysR family transcriptional regulator; Provisional; Region: PRK14997 596153012461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153012462 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 596153012463 putative effector binding pocket; other site 596153012464 dimerization interface [polypeptide binding]; other site 596153012465 malate synthase G; Provisional; Region: PRK02999 596153012466 active site 596153012467 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 596153012468 4-oxalocrotonate tautomerase; Provisional; Region: PRK00745 596153012469 active site 1 [active] 596153012470 dimer interface [polypeptide binding]; other site 596153012471 hexamer interface [polypeptide binding]; other site 596153012472 active site 2 [active] 596153012473 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 596153012474 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 596153012475 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 596153012476 putative active site [active] 596153012477 putative dimer interface [polypeptide binding]; other site 596153012478 glutathione synthetase; Provisional; Region: PRK05246 596153012479 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 596153012480 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 596153012481 benzoate transporter; Region: benE; TIGR00843 596153012482 Benzoate membrane transport protein; Region: BenE; pfam03594 596153012483 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 596153012484 potassium uptake protein; Region: kup; TIGR00794 596153012485 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 596153012486 Glutamate-cysteine ligase; Region: GshA; pfam08886 596153012487 Cation transport protein; Region: TrkH; cl17365 596153012488 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 596153012489 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 596153012490 TrkA-N domain; Region: TrkA_N; pfam02254 596153012491 TrkA-N domain; Region: TrkA_N; pfam02254 596153012492 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 596153012493 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 596153012494 putative catalytic cysteine [active] 596153012495 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 596153012496 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 596153012497 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 596153012498 active site 596153012499 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 596153012500 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 596153012501 Lipopolysaccharide-assembly; Region: LptE; cl01125 596153012502 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 596153012503 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 596153012504 HIGH motif; other site 596153012505 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 596153012506 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 596153012507 active site 596153012508 KMSKS motif; other site 596153012509 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 596153012510 tRNA binding surface [nucleotide binding]; other site 596153012511 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 596153012512 Mechanosensitive ion channel; Region: MS_channel; pfam00924 596153012513 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 596153012514 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 596153012515 NAD(P) binding site [chemical binding]; other site 596153012516 catalytic residues [active] 596153012517 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 596153012518 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153012519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153012520 Walker A motif; other site 596153012521 ATP binding site [chemical binding]; other site 596153012522 Walker B motif; other site 596153012523 arginine finger; other site 596153012524 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 596153012525 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 596153012526 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 596153012527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153012528 putative active site [active] 596153012529 heme pocket [chemical binding]; other site 596153012530 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153012531 putative active site [active] 596153012532 heme pocket [chemical binding]; other site 596153012533 GAF domain; Region: GAF; pfam01590 596153012534 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153012535 metal binding site [ion binding]; metal-binding site 596153012536 active site 596153012537 I-site; other site 596153012538 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 596153012539 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 596153012540 TolR protein; Region: tolR; TIGR02801 596153012541 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 596153012542 dihydrodipicolinate reductase; Provisional; Region: PRK00048 596153012543 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 596153012544 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 596153012545 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 596153012546 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 596153012547 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 596153012548 metal binding site 2 [ion binding]; metal-binding site 596153012549 putative DNA binding helix; other site 596153012550 metal binding site 1 [ion binding]; metal-binding site 596153012551 dimer interface [polypeptide binding]; other site 596153012552 structural Zn2+ binding site [ion binding]; other site 596153012553 HPr kinase/phosphorylase; Provisional; Region: PRK05428 596153012554 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 596153012555 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 596153012556 Hpr binding site; other site 596153012557 active site 596153012558 homohexamer subunit interaction site [polypeptide binding]; other site 596153012559 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 596153012560 active site 596153012561 phosphorylation site [posttranslational modification] 596153012562 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 596153012563 30S subunit binding site; other site 596153012564 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 596153012565 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 596153012566 active site 596153012567 ATP binding site [chemical binding]; other site 596153012568 substrate binding site [chemical binding]; other site 596153012569 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 596153012570 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 596153012571 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 596153012572 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 596153012573 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 596153012574 NAD binding site [chemical binding]; other site 596153012575 ATP-grasp domain; Region: ATP-grasp; pfam02222 596153012576 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 596153012577 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 596153012578 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 596153012579 active site 596153012580 catalytic triad [active] 596153012581 oxyanion hole [active] 596153012582 AAA ATPase domain; Region: AAA_16; pfam13191 596153012583 ATP binding site [chemical binding]; other site 596153012584 Walker A motif; other site 596153012585 Walker B motif; other site 596153012586 arginine finger; other site 596153012587 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 596153012588 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 596153012589 PLD-like domain; Region: PLDc_2; pfam13091 596153012590 putative active site [active] 596153012591 putative active site [active] 596153012592 catalytic site [active] 596153012593 catalytic site [active] 596153012594 WYL domain; Region: WYL; pfam13280 596153012595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 596153012596 non-specific DNA binding site [nucleotide binding]; other site 596153012597 salt bridge; other site 596153012598 sequence-specific DNA binding site [nucleotide binding]; other site 596153012599 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 596153012600 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 596153012601 Transposase domain (DUF772); Region: DUF772; pfam05598 596153012602 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 596153012603 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 596153012604 BNR repeat-like domain; Region: BNR_2; pfam13088 596153012605 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 596153012606 OmpW family; Region: OmpW; cl17427 596153012607 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 596153012608 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 596153012609 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 596153012610 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 596153012611 Glycoprotease family; Region: Peptidase_M22; pfam00814 596153012612 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 596153012613 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 596153012614 Coenzyme A binding pocket [chemical binding]; other site 596153012615 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 596153012616 active site 596153012617 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 596153012618 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 596153012619 Cl binding site [ion binding]; other site 596153012620 oligomer interface [polypeptide binding]; other site 596153012621 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 596153012622 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 596153012623 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 596153012624 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 596153012625 acyl-activating enzyme (AAE) consensus motif; other site 596153012626 putative AMP binding site [chemical binding]; other site 596153012627 putative active site [active] 596153012628 putative CoA binding site [chemical binding]; other site 596153012629 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 596153012630 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 596153012631 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 596153012632 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 596153012633 ligand binding site [chemical binding]; other site 596153012634 homodimer interface [polypeptide binding]; other site 596153012635 NAD(P) binding site [chemical binding]; other site 596153012636 trimer interface B [polypeptide binding]; other site 596153012637 trimer interface A [polypeptide binding]; other site 596153012638 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 596153012639 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 596153012640 intersubunit interface [polypeptide binding]; other site 596153012641 active site 596153012642 zinc binding site [ion binding]; other site 596153012643 Na+ binding site [ion binding]; other site 596153012644 pyruvate kinase; Provisional; Region: PRK05826 596153012645 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 596153012646 domain interfaces; other site 596153012647 active site 596153012648 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 596153012649 proline aminopeptidase P II; Provisional; Region: PRK10879 596153012650 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 596153012651 active site 596153012652 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 596153012653 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153012654 substrate binding site [chemical binding]; other site 596153012655 oxyanion hole (OAH) forming residues; other site 596153012656 trimer interface [polypeptide binding]; other site 596153012657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 596153012658 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153012659 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153012660 thiolase; Provisional; Region: PRK06158 596153012661 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 596153012662 active site 596153012663 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 596153012664 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 596153012665 DUF35 OB-fold domain; Region: DUF35; pfam01796 596153012666 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153012667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153012668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153012669 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 596153012670 putative dimerization interface [polypeptide binding]; other site 596153012671 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 596153012672 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 596153012673 Substrate binding site; other site 596153012674 metal-binding site 596153012675 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 596153012676 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 596153012677 TPP-binding site [chemical binding]; other site 596153012678 dimer interface [polypeptide binding]; other site 596153012679 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 596153012680 PYR/PP interface [polypeptide binding]; other site 596153012681 dimer interface [polypeptide binding]; other site 596153012682 TPP binding site [chemical binding]; other site 596153012683 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 596153012684 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 596153012685 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 596153012686 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 596153012687 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 596153012688 Peptidase C26; Region: Peptidase_C26; pfam07722 596153012689 catalytic triad [active] 596153012690 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 596153012691 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153012692 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 596153012693 putative dimerization interface [polypeptide binding]; other site 596153012694 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 596153012695 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 596153012696 active site 596153012697 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 596153012698 classical (c) SDRs; Region: SDR_c; cd05233 596153012699 NAD(P) binding site [chemical binding]; other site 596153012700 active site 596153012701 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153012702 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 596153012703 Uncharacterized conserved protein [Function unknown]; Region: COG2128 596153012704 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 596153012705 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 596153012706 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 596153012707 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 596153012708 N-terminal plug; other site 596153012709 ligand-binding site [chemical binding]; other site 596153012710 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 596153012711 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153012712 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 596153012713 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153012714 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153012715 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 596153012716 putative effector binding pocket; other site 596153012717 dimerization interface [polypeptide binding]; other site 596153012718 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 596153012719 short chain dehydrogenase; Provisional; Region: PRK06181 596153012720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153012721 NAD(P) binding site [chemical binding]; other site 596153012722 active site 596153012723 Uncharacterized conserved protein [Function unknown]; Region: COG3148 596153012724 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153012725 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153012726 thiolase; Provisional; Region: PRK06158 596153012727 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 596153012728 active site 596153012729 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 596153012730 DUF35 OB-fold domain; Region: DUF35; pfam01796 596153012731 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153012732 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 596153012733 CoA binding domain; Region: CoA_binding_2; pfam13380 596153012734 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 596153012735 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 596153012736 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 596153012737 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 596153012738 C-terminal domain interface [polypeptide binding]; other site 596153012739 GSH binding site (G-site) [chemical binding]; other site 596153012740 dimer interface [polypeptide binding]; other site 596153012741 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 596153012742 dimer interface [polypeptide binding]; other site 596153012743 N-terminal domain interface [polypeptide binding]; other site 596153012744 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 596153012745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153012746 NAD(P) binding site [chemical binding]; other site 596153012747 active site 596153012748 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 596153012749 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 596153012750 DNA topoisomerase III; Provisional; Region: PRK14724 596153012751 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 596153012752 active site 596153012753 putative interdomain interaction site [polypeptide binding]; other site 596153012754 putative metal-binding site [ion binding]; other site 596153012755 putative nucleotide binding site [chemical binding]; other site 596153012756 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 596153012757 domain I; other site 596153012758 DNA binding groove [nucleotide binding] 596153012759 phosphate binding site [ion binding]; other site 596153012760 domain II; other site 596153012761 domain III; other site 596153012762 nucleotide binding site [chemical binding]; other site 596153012763 catalytic site [active] 596153012764 domain IV; other site 596153012765 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 596153012766 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 596153012767 SWI complex, BAF60b domains; Region: SWIB; smart00151 596153012768 Proteins containing SET domain [General function prediction only]; Region: COG2940 596153012769 SET domain; Region: SET; pfam00856 596153012770 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 596153012771 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 596153012772 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 596153012773 Sporulation related domain; Region: SPOR; cl10051 596153012774 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 596153012775 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 596153012776 putative NAD(P) binding site [chemical binding]; other site 596153012777 structural Zn binding site [ion binding]; other site 596153012778 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 596153012779 active site 2 [active] 596153012780 active site 1 [active] 596153012781 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 596153012782 active site 596153012783 catalytic site [active] 596153012784 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153012785 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 596153012786 putative ligand binding site [chemical binding]; other site 596153012787 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 596153012788 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 596153012789 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153012790 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153012791 acyl-activating enzyme (AAE) consensus motif; other site 596153012792 AMP binding site [chemical binding]; other site 596153012793 active site 596153012794 CoA binding site [chemical binding]; other site 596153012795 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 596153012796 MarR family; Region: MarR_2; pfam12802 596153012797 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 596153012798 RES domain; Region: RES; smart00953 596153012799 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 596153012800 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 596153012801 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153012802 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 596153012803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 596153012804 dimer interface [polypeptide binding]; other site 596153012805 phosphorylation site [posttranslational modification] 596153012806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153012807 ATP binding site [chemical binding]; other site 596153012808 Mg2+ binding site [ion binding]; other site 596153012809 G-X-G motif; other site 596153012810 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 596153012811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153012812 active site 596153012813 phosphorylation site [posttranslational modification] 596153012814 intermolecular recognition site; other site 596153012815 dimerization interface [polypeptide binding]; other site 596153012816 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 596153012817 DNA binding site [nucleotide binding] 596153012818 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 596153012819 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 596153012820 catalytic residue [active] 596153012821 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 596153012822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153012823 putative PBP binding loops; other site 596153012824 dimer interface [polypeptide binding]; other site 596153012825 ABC-ATPase subunit interface; other site 596153012826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153012827 dimer interface [polypeptide binding]; other site 596153012828 conserved gate region; other site 596153012829 putative PBP binding loops; other site 596153012830 ABC-ATPase subunit interface; other site 596153012831 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 596153012832 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 596153012833 Walker A/P-loop; other site 596153012834 ATP binding site [chemical binding]; other site 596153012835 Q-loop/lid; other site 596153012836 ABC transporter signature motif; other site 596153012837 Walker B; other site 596153012838 D-loop; other site 596153012839 H-loop/switch region; other site 596153012840 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 596153012841 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 596153012842 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 596153012843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153012844 DNA-binding site [nucleotide binding]; DNA binding site 596153012845 FCD domain; Region: FCD; pfam07729 596153012846 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 596153012847 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 596153012848 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 596153012849 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 596153012850 NAD(P) binding site [chemical binding]; other site 596153012851 catalytic residues [active] 596153012852 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 596153012853 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 596153012854 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 596153012855 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 596153012856 alanine racemase; Reviewed; Region: alr; PRK00053 596153012857 active site 596153012858 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 596153012859 substrate binding site [chemical binding]; other site 596153012860 catalytic residues [active] 596153012861 dimer interface [polypeptide binding]; other site 596153012862 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 596153012863 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 596153012864 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 596153012865 putative DNA binding site [nucleotide binding]; other site 596153012866 AsnC family; Region: AsnC_trans_reg; pfam01037 596153012867 Transcriptional regulators [Transcription]; Region: MarR; COG1846 596153012868 MarR family; Region: MarR_2; pfam12802 596153012869 recombinase A; Provisional; Region: recA; PRK09354 596153012870 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 596153012871 hexamer interface [polypeptide binding]; other site 596153012872 Walker A motif; other site 596153012873 ATP binding site [chemical binding]; other site 596153012874 Walker B motif; other site 596153012875 RecX family; Region: RecX; cl00936 596153012876 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 596153012877 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 596153012878 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 596153012879 Protein export membrane protein; Region: SecD_SecF; pfam02355 596153012880 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 596153012881 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 596153012882 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 596153012883 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 596153012884 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 596153012885 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 596153012886 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 596153012887 dimer interface [polypeptide binding]; other site 596153012888 PYR/PP interface [polypeptide binding]; other site 596153012889 TPP binding site [chemical binding]; other site 596153012890 substrate binding site [chemical binding]; other site 596153012891 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 596153012892 TPP-binding site; other site 596153012893 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 596153012894 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 596153012895 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 596153012896 putative DNA binding site [nucleotide binding]; other site 596153012897 putative Zn2+ binding site [ion binding]; other site 596153012898 AsnC family; Region: AsnC_trans_reg; pfam01037 596153012899 Transmembrane secretion effector; Region: MFS_3; pfam05977 596153012900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153012901 putative substrate translocation pore; other site 596153012902 MltA specific insert domain; Region: MltA; smart00925 596153012903 3D domain; Region: 3D; pfam06725 596153012904 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 596153012905 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 596153012906 ligand binding site [chemical binding]; other site 596153012907 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 596153012908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153012909 active site 596153012910 phosphorylation site [posttranslational modification] 596153012911 intermolecular recognition site; other site 596153012912 dimerization interface [polypeptide binding]; other site 596153012913 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 596153012914 DNA binding residues [nucleotide binding] 596153012915 dimerization interface [polypeptide binding]; other site 596153012916 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 596153012917 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 596153012918 putative active site [active] 596153012919 heme pocket [chemical binding]; other site 596153012920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153012921 ATP binding site [chemical binding]; other site 596153012922 Mg2+ binding site [ion binding]; other site 596153012923 G-X-G motif; other site 596153012924 nitrilase; Region: PLN02798 596153012925 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 596153012926 putative active site [active] 596153012927 catalytic triad [active] 596153012928 dimer interface [polypeptide binding]; other site 596153012929 TIGR02099 family protein; Region: TIGR02099 596153012930 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 596153012931 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 596153012932 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 596153012933 metal binding triad; other site 596153012934 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 596153012935 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 596153012936 metal binding triad; other site 596153012937 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 596153012938 HlyD family secretion protein; Region: HlyD_3; pfam13437 596153012939 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 596153012940 Protein export membrane protein; Region: SecD_SecF; cl14618 596153012941 putative glutathione S-transferase; Provisional; Region: PRK10357 596153012942 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 596153012943 putative C-terminal domain interface [polypeptide binding]; other site 596153012944 putative GSH binding site (G-site) [chemical binding]; other site 596153012945 putative dimer interface [polypeptide binding]; other site 596153012946 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 596153012947 dimer interface [polypeptide binding]; other site 596153012948 N-terminal domain interface [polypeptide binding]; other site 596153012949 putative substrate binding pocket (H-site) [chemical binding]; other site 596153012950 adenylosuccinate lyase; Provisional; Region: PRK09285 596153012951 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 596153012952 tetramer interface [polypeptide binding]; other site 596153012953 active site 596153012954 YaeQ protein; Region: YaeQ; pfam07152 596153012955 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 596153012956 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 596153012957 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 596153012958 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 596153012959 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153012960 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 596153012961 dimerization interface [polypeptide binding]; other site 596153012962 substrate binding pocket [chemical binding]; other site 596153012963 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153012964 Predicted membrane protein [Function unknown]; Region: COG1950 596153012965 Peptidase family M48; Region: Peptidase_M48; cl12018 596153012966 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 596153012967 trimer interface [polypeptide binding]; other site 596153012968 dimer interface [polypeptide binding]; other site 596153012969 putative active site [active] 596153012970 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 596153012971 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 596153012972 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 596153012973 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 596153012974 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 596153012975 phosphopeptide binding site; other site 596153012976 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 596153012977 active site 596153012978 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 596153012979 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 596153012980 CoA binding domain; Region: CoA_binding; smart00881 596153012981 CoA-ligase; Region: Ligase_CoA; pfam00549 596153012982 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 596153012983 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 596153012984 CoA-ligase; Region: Ligase_CoA; pfam00549 596153012985 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 596153012986 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 596153012987 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 596153012988 DNA protecting protein DprA; Region: dprA; TIGR00732 596153012989 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 596153012990 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 596153012991 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 596153012992 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 596153012993 active site 596153012994 catalytic residues [active] 596153012995 metal binding site [ion binding]; metal-binding site 596153012996 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 596153012997 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 596153012998 putative active site [active] 596153012999 substrate binding site [chemical binding]; other site 596153013000 putative cosubstrate binding site; other site 596153013001 catalytic site [active] 596153013002 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 596153013003 substrate binding site [chemical binding]; other site 596153013004 AzlC protein; Region: AzlC; pfam03591 596153013005 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 596153013006 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 596153013007 Phosphoglycerate kinase; Region: PGK; pfam00162 596153013008 substrate binding site [chemical binding]; other site 596153013009 hinge regions; other site 596153013010 ADP binding site [chemical binding]; other site 596153013011 catalytic site [active] 596153013012 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 596153013013 EamA-like transporter family; Region: EamA; pfam00892 596153013014 EamA-like transporter family; Region: EamA; pfam00892 596153013015 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 596153013016 active site 596153013017 dimer interface [polypeptide binding]; other site 596153013018 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153013019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153013020 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 596153013021 dimerization interface [polypeptide binding]; other site 596153013022 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153013023 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 596153013024 active site 596153013025 Zn binding site [ion binding]; other site 596153013026 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 596153013027 dimerization interface [polypeptide binding]; other site 596153013028 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 596153013029 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 596153013030 dimer interface [polypeptide binding]; other site 596153013031 putative CheW interface [polypeptide binding]; other site 596153013032 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 596153013033 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 596153013034 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 596153013035 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 596153013036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 596153013037 putative substrate translocation pore; other site 596153013038 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 596153013039 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 596153013040 dimer interface [polypeptide binding]; other site 596153013041 ssDNA binding site [nucleotide binding]; other site 596153013042 tetramer (dimer of dimers) interface [polypeptide binding]; other site 596153013043 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153013044 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 596153013045 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153013046 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153013047 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153013048 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153013049 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 596153013050 CoenzymeA binding site [chemical binding]; other site 596153013051 subunit interaction site [polypeptide binding]; other site 596153013052 PHB binding site; other site 596153013053 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 596153013054 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153013055 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 596153013056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153013057 NAD(P) binding site [chemical binding]; other site 596153013058 active site 596153013059 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 596153013060 active site 2 [active] 596153013061 active site 1 [active] 596153013062 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153013063 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153013064 active site 596153013065 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153013066 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153013067 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 596153013068 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 596153013069 substrate binding site [chemical binding]; other site 596153013070 oxyanion hole (OAH) forming residues; other site 596153013071 trimer interface [polypeptide binding]; other site 596153013072 L-lactate permease; Region: Lactate_perm; cl00701 596153013073 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 596153013074 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 596153013075 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 596153013076 Ligand Binding Site [chemical binding]; other site 596153013077 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153013078 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153013079 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 596153013080 putative dimerization interface [polypeptide binding]; other site 596153013081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 596153013082 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153013083 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 596153013084 trimer interface [polypeptide binding]; other site 596153013085 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 596153013086 eyelet of channel; other site 596153013087 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 596153013088 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153013089 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 596153013090 putative dimerization interface [polypeptide binding]; other site 596153013091 tricarballylate dehydrogenase; Validated; Region: PRK08274 596153013092 tricarballylate utilization protein B; Provisional; Region: PRK15033 596153013093 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153013094 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 596153013095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153013096 Walker A motif; other site 596153013097 ATP binding site [chemical binding]; other site 596153013098 Walker B motif; other site 596153013099 arginine finger; other site 596153013100 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 596153013101 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 596153013102 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 596153013103 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153013104 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 596153013105 CoA binding domain; Region: CoA_binding_2; pfam13380 596153013106 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 596153013107 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 596153013108 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 596153013109 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 596153013110 ATP-grasp domain; Region: ATP-grasp_4; cl17255 596153013111 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 596153013112 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 596153013113 carboxyltransferase (CT) interaction site; other site 596153013114 biotinylation site [posttranslational modification]; other site 596153013115 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 596153013116 CoenzymeA binding site [chemical binding]; other site 596153013117 subunit interaction site [polypeptide binding]; other site 596153013118 PHB binding site; other site 596153013119 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 596153013120 nudix motif; other site 596153013121 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 596153013122 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 596153013123 N-terminal plug; other site 596153013124 ligand-binding site [chemical binding]; other site 596153013125 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 596153013126 CoenzymeA binding site [chemical binding]; other site 596153013127 subunit interaction site [polypeptide binding]; other site 596153013128 PHB binding site; other site 596153013129 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153013130 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 596153013131 putative DNA binding site [nucleotide binding]; other site 596153013132 putative Zn2+ binding site [ion binding]; other site 596153013133 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153013134 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153013135 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153013136 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153013137 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 596153013138 active site 596153013139 catalytic site [active] 596153013140 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 596153013141 active site 2 [active] 596153013142 active site 1 [active] 596153013143 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 596153013144 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 596153013145 acyl-activating enzyme (AAE) consensus motif; other site 596153013146 AMP binding site [chemical binding]; other site 596153013147 active site 596153013148 CoA binding site [chemical binding]; other site 596153013149 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 596153013150 Lumazine binding domain; Region: Lum_binding; pfam00677 596153013151 Lumazine binding domain; Region: Lum_binding; pfam00677 596153013152 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 596153013153 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 596153013154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 596153013155 ATP binding site [chemical binding]; other site 596153013156 Mg2+ binding site [ion binding]; other site 596153013157 G-X-G motif; other site 596153013158 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 596153013159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 596153013160 active site 596153013161 phosphorylation site [posttranslational modification] 596153013162 intermolecular recognition site; other site 596153013163 dimerization interface [polypeptide binding]; other site 596153013164 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 596153013165 DNA binding site [nucleotide binding] 596153013166 Predicted membrane protein [Function unknown]; Region: COG3212 596153013167 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 596153013168 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 596153013169 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 596153013170 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 596153013171 FAD binding pocket [chemical binding]; other site 596153013172 FAD binding motif [chemical binding]; other site 596153013173 phosphate binding motif [ion binding]; other site 596153013174 beta-alpha-beta structure motif; other site 596153013175 NAD binding pocket [chemical binding]; other site 596153013176 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 596153013177 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 596153013178 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 596153013179 Flavodoxin; Region: Flavodoxin_1; pfam00258 596153013180 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 596153013181 FAD binding pocket [chemical binding]; other site 596153013182 conserved FAD binding motif [chemical binding]; other site 596153013183 phosphate binding motif [ion binding]; other site 596153013184 beta-alpha-beta structure motif; other site 596153013185 NAD binding pocket [chemical binding]; other site 596153013186 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 596153013187 ApbE family; Region: ApbE; pfam02424 596153013188 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 596153013189 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 596153013190 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 596153013191 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 596153013192 motif II; other site 596153013193 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 596153013194 Nitronate monooxygenase; Region: NMO; pfam03060 596153013195 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 596153013196 FMN binding site [chemical binding]; other site 596153013197 substrate binding site [chemical binding]; other site 596153013198 putative catalytic residue [active] 596153013199 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153013200 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153013201 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153013202 active site 596153013203 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 596153013204 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153013205 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153013206 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153013207 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153013208 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 596153013209 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 596153013210 NADP binding site [chemical binding]; other site 596153013211 dimer interface [polypeptide binding]; other site 596153013212 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 596153013213 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 596153013214 active site 596153013215 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153013216 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 596153013217 Transcriptional regulator [Transcription]; Region: IclR; COG1414 596153013218 Bacterial transcriptional regulator; Region: IclR; pfam01614 596153013219 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 596153013220 CoA-transferase family III; Region: CoA_transf_3; pfam02515 596153013221 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 596153013222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153013223 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153013224 dimerization interface [polypeptide binding]; other site 596153013225 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 596153013226 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 596153013227 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 596153013228 spermidine synthase; Provisional; Region: PRK03612 596153013229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 596153013230 S-adenosylmethionine binding site [chemical binding]; other site 596153013231 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 596153013232 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 596153013233 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 596153013234 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 596153013235 Short C-terminal domain; Region: SHOCT; pfam09851 596153013236 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 596153013237 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 596153013238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 596153013239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153013240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 596153013241 dimerization interface [polypeptide binding]; other site 596153013242 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 596153013243 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 596153013244 inhibitor-cofactor binding pocket; inhibition site 596153013245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 596153013246 catalytic residue [active] 596153013247 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 596153013248 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 596153013249 tetrameric interface [polypeptide binding]; other site 596153013250 NAD binding site [chemical binding]; other site 596153013251 catalytic residues [active] 596153013252 MASE2 domain; Region: MASE2; pfam05230 596153013253 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153013254 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153013255 metal binding site [ion binding]; metal-binding site 596153013256 active site 596153013257 I-site; other site 596153013258 Transcriptional regulators [Transcription]; Region: FadR; COG2186 596153013259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 596153013260 DNA-binding site [nucleotide binding]; DNA binding site 596153013261 FCD domain; Region: FCD; pfam07729 596153013262 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 596153013263 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 596153013264 putative ligand binding site [chemical binding]; other site 596153013265 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 596153013266 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 596153013267 TM-ABC transporter signature motif; other site 596153013268 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 596153013269 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 596153013270 TM-ABC transporter signature motif; other site 596153013271 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 596153013272 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 596153013273 Walker A/P-loop; other site 596153013274 ATP binding site [chemical binding]; other site 596153013275 Q-loop/lid; other site 596153013276 ABC transporter signature motif; other site 596153013277 Walker B; other site 596153013278 D-loop; other site 596153013279 H-loop/switch region; other site 596153013280 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 596153013281 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 596153013282 Walker A/P-loop; other site 596153013283 ATP binding site [chemical binding]; other site 596153013284 Q-loop/lid; other site 596153013285 ABC transporter signature motif; other site 596153013286 Walker B; other site 596153013287 D-loop; other site 596153013288 H-loop/switch region; other site 596153013289 allantoate amidohydrolase; Reviewed; Region: PRK12893 596153013290 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 596153013291 active site 596153013292 metal binding site [ion binding]; metal-binding site 596153013293 dimer interface [polypeptide binding]; other site 596153013294 Uncharacterized conserved protein [Function unknown]; Region: COG5476 596153013295 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 596153013296 MlrC C-terminus; Region: MlrC_C; pfam07171 596153013297 Malate dehydrogenase enzyme; Region: Malate_DH; pfam12434 596153013298 malic enzyme; Reviewed; Region: PRK12862 596153013299 Malic enzyme, N-terminal domain; Region: malic; pfam00390 596153013300 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 596153013301 putative NAD(P) binding site [chemical binding]; other site 596153013302 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 596153013303 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 596153013304 active site 596153013305 barstar interaction site; other site 596153013306 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 596153013307 putative RNAase interaction site [polypeptide binding]; other site 596153013308 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 596153013309 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 596153013310 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 596153013311 SurA N-terminal domain; Region: SurA_N; pfam09312 596153013312 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 596153013313 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 596153013314 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 596153013315 Organic solvent tolerance protein; Region: OstA_C; pfam04453 596153013316 Phosphotransferase enzyme family; Region: APH; pfam01636 596153013317 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 596153013318 substrate binding site [chemical binding]; other site 596153013319 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 596153013320 RNA methyltransferase, RsmE family; Region: TIGR00046 596153013321 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 596153013322 AAA domain; Region: AAA_23; pfam13476 596153013323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 596153013324 ABC transporter signature motif; other site 596153013325 Walker B; other site 596153013326 D-loop; other site 596153013327 H-loop/switch region; other site 596153013328 hypothetical protein; Provisional; Region: PRK07907 596153013329 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 596153013330 metal binding site [ion binding]; metal-binding site 596153013331 putative dimer interface [polypeptide binding]; other site 596153013332 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 596153013333 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 596153013334 metal binding site [ion binding]; metal-binding site 596153013335 active site 596153013336 I-site; other site 596153013337 P63C domain; Region: P63C; pfam10546 596153013338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 596153013339 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 596153013340 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 596153013341 Predicted membrane protein [Function unknown]; Region: COG2119 596153013342 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 596153013343 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 596153013344 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 596153013345 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 596153013346 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 596153013347 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 596153013348 short chain dehydrogenase; Provisional; Region: PRK07024 596153013349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153013350 NAD(P) binding site [chemical binding]; other site 596153013351 active site 596153013352 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 596153013353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 596153013354 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 596153013355 active site 596153013356 motif I; other site 596153013357 motif II; other site 596153013358 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 596153013359 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 596153013360 putative active site [active] 596153013361 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 596153013362 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 596153013363 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 596153013364 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 596153013365 TrkA-N domain; Region: TrkA_N; pfam02254 596153013366 TrkA-C domain; Region: TrkA_C; pfam02080 596153013367 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 596153013368 active site 596153013369 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 596153013370 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 596153013371 ligand binding site [chemical binding]; other site 596153013372 flexible hinge region; other site 596153013373 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 596153013374 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 596153013375 trmE is a tRNA modification GTPase; Region: trmE; cd04164 596153013376 G1 box; other site 596153013377 GTP/Mg2+ binding site [chemical binding]; other site 596153013378 Switch I region; other site 596153013379 G2 box; other site 596153013380 Switch II region; other site 596153013381 G3 box; other site 596153013382 G4 box; other site 596153013383 G5 box; other site 596153013384 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 596153013385 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 596153013386 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 596153013387 substrate binding pocket [chemical binding]; other site 596153013388 membrane-bound complex binding site; other site 596153013389 hinge residues; other site 596153013390 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 596153013391 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 596153013392 hydroxyglutarate oxidase; Provisional; Region: PRK11728 596153013393 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 596153013394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 596153013395 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 596153013396 dimerization interface [polypeptide binding]; other site 596153013397 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 596153013398 aspartate racemase; Region: asp_race; TIGR00035 596153013399 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 596153013400 SxDxEG motif; other site 596153013401 active site 596153013402 metal binding site [ion binding]; metal-binding site 596153013403 homopentamer interface [polypeptide binding]; other site 596153013404 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 596153013405 homodimer interface [polypeptide binding]; other site 596153013406 homotetramer interface [polypeptide binding]; other site 596153013407 active site pocket [active] 596153013408 cleavage site 596153013409 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 596153013410 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 596153013411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153013412 dimer interface [polypeptide binding]; other site 596153013413 conserved gate region; other site 596153013414 putative PBP binding loops; other site 596153013415 ABC-ATPase subunit interface; other site 596153013416 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 596153013417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 596153013418 dimer interface [polypeptide binding]; other site 596153013419 conserved gate region; other site 596153013420 putative PBP binding loops; other site 596153013421 ABC-ATPase subunit interface; other site 596153013422 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 596153013423 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 596153013424 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 596153013425 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 596153013426 Walker A/P-loop; other site 596153013427 ATP binding site [chemical binding]; other site 596153013428 Q-loop/lid; other site 596153013429 ABC transporter signature motif; other site 596153013430 Walker B; other site 596153013431 D-loop; other site 596153013432 H-loop/switch region; other site 596153013433 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 596153013434 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 596153013435 Walker A/P-loop; other site 596153013436 ATP binding site [chemical binding]; other site 596153013437 Q-loop/lid; other site 596153013438 ABC transporter signature motif; other site 596153013439 Walker B; other site 596153013440 D-loop; other site 596153013441 H-loop/switch region; other site 596153013442 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 596153013443 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 596153013444 catalytic nucleophile [active] 596153013445 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 596153013446 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 596153013447 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 596153013448 putative active site [active] 596153013449 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 596153013450 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 596153013451 membrane protein insertase; Provisional; Region: PRK01318 596153013452 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 596153013453 hypothetical protein; Provisional; Region: PRK14389 596153013454 Ribonuclease P; Region: Ribonuclease_P; pfam00825 596153013455 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 596153013456 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 596153013457 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 596153013458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 596153013459 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 596153013460 active site 596153013461 metal binding site [ion binding]; metal-binding site 596153013462 interdomain interaction site; other site 596153013463 DNA topoisomerase III; Provisional; Region: PRK07726 596153013464 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 596153013465 active site 596153013466 putative interdomain interaction site [polypeptide binding]; other site 596153013467 putative metal-binding site [ion binding]; other site 596153013468 putative nucleotide binding site [chemical binding]; other site 596153013469 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 596153013470 domain I; other site 596153013471 DNA binding groove [nucleotide binding] 596153013472 phosphate binding site [ion binding]; other site 596153013473 domain II; other site 596153013474 domain III; other site 596153013475 nucleotide binding site [chemical binding]; other site 596153013476 catalytic site [active] 596153013477 domain IV; other site 596153013478 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 596153013479 conjugal transfer peptidase TraF; Provisional; Region: PRK13884 596153013480 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 596153013481 conjugal transfer coupling protein TraG; Provisional; Region: PRK13880 596153013482 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 596153013483 Walker A motif; other site 596153013484 ATP binding site [chemical binding]; other site 596153013485 Walker B motif; other site 596153013486 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 596153013487 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 596153013488 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 596153013489 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 596153013490 P-loop; other site 596153013491 conjugal transfer protein TraM; Provisional; Region: PRK13895 596153013492 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 596153013493 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 596153013494 ParB-like nuclease domain; Region: ParB; smart00470 596153013495 KorB domain; Region: KorB; pfam08535 596153013496 KorB C-terminal beta-barrel domain; Region: KorB_C; pfam06613 596153013497 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 596153013498 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 596153013499 P-loop; other site 596153013500 Magnesium ion binding site [ion binding]; other site 596153013501 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 596153013502 Magnesium ion binding site [ion binding]; other site 596153013503 conjugal transfer protein TrbA; Provisional; Region: PRK13890 596153013504 Protein of unknown function (DUF2761); Region: DUF2761; pfam10959 596153013505 Protein of unknown function (DUF2688); Region: DUF2688; pfam10892 596153013506 Sec1 family; Region: Sec1; cl15415 596153013507 Antirestriction protein; Region: Antirestrict; pfam03230 596153013508 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153013509 Transposase; Region: HTH_Tnp_1; cl17663 596153013510 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 596153013511 CoenzymeA binding site [chemical binding]; other site 596153013512 subunit interaction site [polypeptide binding]; other site 596153013513 PHB binding site; other site 596153013514 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 596153013515 Integrase core domain; Region: rve; pfam00665 596153013516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 596153013517 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 596153013518 Walker A motif; other site 596153013519 ATP binding site [chemical binding]; other site 596153013520 Walker B motif; other site 596153013521 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 596153013522 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 596153013523 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 596153013524 catalytic residues [active] 596153013525 catalytic nucleophile [active] 596153013526 Presynaptic Site I dimer interface [polypeptide binding]; other site 596153013527 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 596153013528 Synaptic Flat tetramer interface [polypeptide binding]; other site 596153013529 Synaptic Site I dimer interface [polypeptide binding]; other site 596153013530 DNA binding site [nucleotide binding] 596153013531 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 596153013532 DNA-binding interface [nucleotide binding]; DNA binding site 596153013533 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 596153013534 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 596153013535 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 596153013536 Transposase; Region: HTH_Tnp_1; pfam01527 596153013537 Divergent AAA domain; Region: AAA_4; pfam04326 596153013538 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 596153013539 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 596153013540 C-terminal domain interface [polypeptide binding]; other site 596153013541 GSH binding site (G-site) [chemical binding]; other site 596153013542 dimer interface [polypeptide binding]; other site 596153013543 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 596153013544 N-terminal domain interface [polypeptide binding]; other site 596153013545 putative dimer interface [polypeptide binding]; other site 596153013546 active site 596153013547 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 596153013548 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 596153013549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 596153013550 NAD(P) binding site [chemical binding]; other site 596153013551 active site 596153013552 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 596153013553 C-terminal domain interface [polypeptide binding]; other site 596153013554 GSH binding site (G-site) [chemical binding]; other site 596153013555 dimer interface [polypeptide binding]; other site 596153013556 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 596153013557 N-terminal domain interface [polypeptide binding]; other site 596153013558 dimer interface [polypeptide binding]; other site 596153013559 substrate binding pocket (H-site) [chemical binding]; other site 596153013560 EamA-like transporter family; Region: EamA; pfam00892 596153013561 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 596153013562 EamA-like transporter family; Region: EamA; pfam00892 596153013563 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 596153013564 putative catalytic residues [active] 596153013565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 596153013566 RelB antitoxin; Region: RelB; cl01171 596153013567 TrfA protein; Region: TrfA; pfam07042 596153013568 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 596153013569 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 596153013570 dimer interface [polypeptide binding]; other site 596153013571 ssDNA binding site [nucleotide binding]; other site 596153013572 tetramer (dimer of dimers) interface [polypeptide binding]; other site 596153013573 conjugal transfer protein TrbA; Provisional; Region: PRK13890 596153013574 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 596153013575 salt bridge; other site 596153013576 non-specific DNA binding site [nucleotide binding]; other site 596153013577 sequence-specific DNA binding site [nucleotide binding]; other site 596153013578 conjugal transfer ATPase TrbB; Provisional; Region: PRK13894 596153013579 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 596153013580 ATP binding site [chemical binding]; other site 596153013581 Walker A motif; other site 596153013582 hexamer interface [polypeptide binding]; other site 596153013583 Walker B motif; other site 596153013584 conjugal transfer protein TrbC; Provisional; Region: PRK13892 596153013585 conjugal transfer protein TrbD; Provisional; Region: PRK13823 596153013586 conjugal transfer protein TrbE; Provisional; Region: PRK13891 596153013587 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 596153013588 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 596153013589 Walker A motif; other site 596153013590 ATP binding site [chemical binding]; other site 596153013591 Walker B motif; other site 596153013592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 596153013593 Walker B; other site 596153013594 D-loop; other site 596153013595 H-loop/switch region; other site 596153013596 conjugal transfer protein TrbF; Provisional; Region: PRK13887 596153013597 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 596153013598 VirB7 interaction site; other site 596153013599 conjugal transfer protein TrbH; Provisional; Region: PRK13883 596153013600 Conjugal transfer protein TrbH; Region: TrbH; pfam07283 596153013601 conjugal transfer protein TrbI; Provisional; Region: PRK13881 596153013602 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 596153013603 conjugal transfer protein TrbJ; Provisional; Region: PRK13879 596153013604 entry exclusion lipoprotein TrbK; Region: TrbK_RP4; TIGR04359 596153013605 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 596153013606 conjugal transfer protein TrbM; Provisional; Region: PRK13893 596153013607 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 596153013608 N-acetyl-D-glucosamine binding site [chemical binding]; other site 596153013609 catalytic residue [active] 596153013610 conjugal transfer protein TrbP; Provisional; Region: PRK13882 596153013611 TraX protein; Region: TraX; pfam05857 596153013612 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 596153013613 ligand binding site [chemical binding]; other site 596153013614 multiple promoter invertase; Provisional; Region: mpi; PRK13413 596153013615 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 596153013616 catalytic residues [active] 596153013617 catalytic nucleophile [active] 596153013618 Presynaptic Site I dimer interface [polypeptide binding]; other site 596153013619 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 596153013620 Synaptic Flat tetramer interface [polypeptide binding]; other site 596153013621 Synaptic Site I dimer interface [polypeptide binding]; other site 596153013622 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 596153013623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 596153013624 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 596153013625 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 596153013626 Integrase core domain; Region: rve; pfam00665 596153013627 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 596153013628 Bacterial TniB protein; Region: TniB; pfam05621 596153013629 TniQ; Region: TniQ; pfam06527 596153013630 multiple promoter invertase; Provisional; Region: mpi; PRK13413 596153013631 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 596153013632 catalytic residues [active] 596153013633 catalytic nucleophile [active] 596153013634 Presynaptic Site I dimer interface [polypeptide binding]; other site 596153013635 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 596153013636 Synaptic Flat tetramer interface [polypeptide binding]; other site 596153013637 Synaptic Site I dimer interface [polypeptide binding]; other site 596153013638 DNA binding site [nucleotide binding] 596153013639 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 596153013640 DNA-binding interface [nucleotide binding]; DNA binding site 596153013641 putative mercury resistance protein; Provisional; Region: PRK13747 596153013642 transcriptional regulator MerD; Provisional; Region: PRK13749 596153013643 Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111 596153013644 DNA binding residues [nucleotide binding] 596153013645 putative dimer interface [polypeptide binding]; other site 596153013646 putative mercuric reductase; Provisional; Region: PRK13748 596153013647 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 596153013648 metal-binding site [ion binding] 596153013649 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 596153013650 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 596153013651 Membrane transport protein MerF; Region: Transport_MerF; pfam11431 596153013652 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 596153013653 metal-binding site [ion binding] 596153013654 putative mercuric transport protein; Provisional; Region: PRK13751 596153013655 putative transcriptional regulator MerR; Provisional; Region: PRK13752 596153013656 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 596153013657 DNA binding residues [nucleotide binding] 596153013658 dimer interface [polypeptide binding]; other site 596153013659 mercury binding site [ion binding]; other site 596153013660 Uncharacterized conserved protein [Function unknown]; Region: COG2128 596153013661 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 596153013662 Cupin; Region: Cupin_6; pfam12852 596153013663 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 596153013664 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 596153013665 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 596153013666 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 596153013667 active site 596153013668 NTP binding site [chemical binding]; other site 596153013669 metal binding triad [ion binding]; metal-binding site 596153013670 antibiotic binding site [chemical binding]; other site 596153013671 Uncharacterized conserved protein [Function unknown]; Region: COG2361 596153013672 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 596153013673 multiple promoter invertase; Provisional; Region: mpi; PRK13413 596153013674 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 596153013675 catalytic residues [active] 596153013676 catalytic nucleophile [active] 596153013677 Presynaptic Site I dimer interface [polypeptide binding]; other site 596153013678 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 596153013679 Synaptic Flat tetramer interface [polypeptide binding]; other site 596153013680 Synaptic Site I dimer interface [polypeptide binding]; other site 596153013681 DNA binding site [nucleotide binding] 596153013682 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 596153013683 DNA-binding interface [nucleotide binding]; DNA binding site