-- dump date   	20140618_193822
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
596154000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
596154000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
596154000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154000004	Walker A motif; other site
596154000005	ATP binding site [chemical binding]; other site
596154000006	Walker B motif; other site
596154000007	arginine finger; other site
596154000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
596154000009	DnaA box-binding interface [nucleotide binding]; other site
596154000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
596154000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
596154000012	putative DNA binding surface [nucleotide binding]; other site
596154000013	dimer interface [polypeptide binding]; other site
596154000014	beta-clamp/clamp loader binding surface; other site
596154000015	beta-clamp/translesion DNA polymerase binding surface; other site
596154000016	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
596154000017	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154000018	ATP binding site [chemical binding]; other site
596154000019	Mg2+ binding site [ion binding]; other site
596154000020	G-X-G motif; other site
596154000021	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
596154000022	anchoring element; other site
596154000023	dimer interface [polypeptide binding]; other site
596154000024	ATP binding site [chemical binding]; other site
596154000025	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
596154000026	active site
596154000027	putative metal-binding site [ion binding]; other site
596154000028	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
596154000029	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154000030	salt bridge; other site
596154000031	non-specific DNA binding site [nucleotide binding]; other site
596154000032	sequence-specific DNA binding site [nucleotide binding]; other site
596154000033	Domain of unknown function (DUF955); Region: DUF955; cl01076
596154000034	putative transposase OrfB; Reviewed; Region: PHA02517
596154000035	HTH-like domain; Region: HTH_21; pfam13276
596154000036	Integrase core domain; Region: rve; pfam00665
596154000037	Integrase core domain; Region: rve_3; cl15866
596154000038	Transposase; Region: HTH_Tnp_1; cl17663
596154000039	Flagellin N-methylase; Region: FliB; pfam03692
596154000040	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154000041	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154000042	enoyl-CoA hydratase; Provisional; Region: PRK05995
596154000043	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154000044	substrate binding site [chemical binding]; other site
596154000045	oxyanion hole (OAH) forming residues; other site
596154000046	trimer interface [polypeptide binding]; other site
596154000047	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154000048	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154000049	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154000050	dimerization interface [polypeptide binding]; other site
596154000051	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000052	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
596154000053	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
596154000054	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
596154000055	ATP-grasp domain; Region: ATP-grasp_4; cl17255
596154000056	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
596154000057	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
596154000058	carboxyltransferase (CT) interaction site; other site
596154000059	biotinylation site [posttranslational modification]; other site
596154000060	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154000061	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154000062	active site
596154000063	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
596154000064	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
596154000065	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
596154000066	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
596154000067	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
596154000068	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
596154000069	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
596154000070	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
596154000071	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
596154000072	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
596154000073	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
596154000074	active site
596154000075	catalytic site [active]
596154000076	substrate binding site [chemical binding]; other site
596154000077	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
596154000078	NlpC/P60 family; Region: NLPC_P60; pfam00877
596154000079	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
596154000080	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
596154000081	GAF domain; Region: GAF_3; pfam13492
596154000082	PAS domain S-box; Region: sensory_box; TIGR00229
596154000083	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154000084	putative active site [active]
596154000085	heme pocket [chemical binding]; other site
596154000086	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
596154000087	GAF domain; Region: GAF; pfam01590
596154000088	PAS domain S-box; Region: sensory_box; TIGR00229
596154000089	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154000090	putative active site [active]
596154000091	heme pocket [chemical binding]; other site
596154000092	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154000093	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154000094	metal binding site [ion binding]; metal-binding site
596154000095	active site
596154000096	I-site; other site
596154000097	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
596154000098	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
596154000099	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154000100	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154000101	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000102	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154000103	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
596154000104	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154000105	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154000106	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
596154000107	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
596154000108	FAD binding site [chemical binding]; other site
596154000109	substrate binding site [chemical binding]; other site
596154000110	catalytic base [active]
596154000111	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000112	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
596154000113	CoA binding domain; Region: CoA_binding_2; pfam13380
596154000114	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
596154000115	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
596154000116	enoyl-CoA hydratase; Provisional; Region: PRK08290
596154000117	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154000118	substrate binding site [chemical binding]; other site
596154000119	oxyanion hole (OAH) forming residues; other site
596154000120	trimer interface [polypeptide binding]; other site
596154000121	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154000122	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
596154000123	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
596154000124	LTXXQ motif family protein; Region: LTXXQ; pfam07813
596154000125	recombination associated protein; Reviewed; Region: rdgC; PRK00321
596154000126	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
596154000127	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
596154000128	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
596154000129	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
596154000130	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
596154000131	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
596154000132	DNA binding residues [nucleotide binding]
596154000133	dimer interface [polypeptide binding]; other site
596154000134	copper binding site [ion binding]; other site
596154000135	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
596154000136	metal-binding site [ion binding]
596154000137	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
596154000138	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
596154000139	metal-binding site [ion binding]
596154000140	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
596154000141	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
596154000142	motif II; other site
596154000143	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
596154000144	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
596154000145	dimerization interface [polypeptide binding]; other site
596154000146	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
596154000147	dimer interface [polypeptide binding]; other site
596154000148	putative CheW interface [polypeptide binding]; other site
596154000149	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
596154000150	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
596154000151	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154000152	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
596154000153	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154000154	active site
596154000155	phosphorylation site [posttranslational modification]
596154000156	intermolecular recognition site; other site
596154000157	dimerization interface [polypeptide binding]; other site
596154000158	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
596154000159	DNA binding site [nucleotide binding]
596154000160	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
596154000161	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
596154000162	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154000163	dimer interface [polypeptide binding]; other site
596154000164	phosphorylation site [posttranslational modification]
596154000165	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154000166	ATP binding site [chemical binding]; other site
596154000167	Mg2+ binding site [ion binding]; other site
596154000168	G-X-G motif; other site
596154000169	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
596154000170	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
596154000171	FMN binding site [chemical binding]; other site
596154000172	active site
596154000173	substrate binding site [chemical binding]; other site
596154000174	catalytic residue [active]
596154000175	glutathionine S-transferase; Provisional; Region: PRK10542
596154000176	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
596154000177	C-terminal domain interface [polypeptide binding]; other site
596154000178	GSH binding site (G-site) [chemical binding]; other site
596154000179	dimer interface [polypeptide binding]; other site
596154000180	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
596154000181	dimer interface [polypeptide binding]; other site
596154000182	N-terminal domain interface [polypeptide binding]; other site
596154000183	substrate binding pocket (H-site) [chemical binding]; other site
596154000184	Predicted flavoprotein [General function prediction only]; Region: COG0431
596154000185	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
596154000186	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
596154000187	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
596154000188	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
596154000189	DNA polymerase IV; Provisional; Region: PRK02794
596154000190	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
596154000191	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
596154000192	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
596154000193	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
596154000194	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
596154000195	P-loop; other site
596154000196	Magnesium ion binding site [ion binding]; other site
596154000197	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
596154000198	Magnesium ion binding site [ion binding]; other site
596154000199	Serine hydrolase; Region: Ser_hydrolase; pfam06821
596154000200	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
596154000201	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
596154000202	ParB-like nuclease domain; Region: ParB; smart00470
596154000203	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
596154000204	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
596154000205	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
596154000206	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154000207	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
596154000208	Mechanosensitive ion channel; Region: MS_channel; pfam00924
596154000209	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
596154000210	FAD binding domain; Region: FAD_binding_4; pfam01565
596154000211	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
596154000212	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
596154000213	CoenzymeA binding site [chemical binding]; other site
596154000214	subunit interaction site [polypeptide binding]; other site
596154000215	PHB binding site; other site
596154000216	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
596154000217	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
596154000218	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
596154000219	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
596154000220	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154000221	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154000222	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154000223	dimerization interface [polypeptide binding]; other site
596154000224	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000225	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
596154000226	classical (c) SDRs; Region: SDR_c; cd05233
596154000227	NAD(P) binding site [chemical binding]; other site
596154000228	active site
596154000229	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
596154000230	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154000231	NAD(P) binding site [chemical binding]; other site
596154000232	active site
596154000233	Uncharacterized conserved protein [Function unknown]; Region: COG2128
596154000234	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
596154000235	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
596154000236	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
596154000237	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
596154000238	hypothetical protein; Provisional; Region: PRK09126
596154000239	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
596154000240	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
596154000241	acyl-activating enzyme (AAE) consensus motif; other site
596154000242	putative AMP binding site [chemical binding]; other site
596154000243	putative active site [active]
596154000244	putative CoA binding site [chemical binding]; other site
596154000245	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154000246	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154000247	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
596154000248	dimerization interface [polypeptide binding]; other site
596154000249	substrate binding pocket [chemical binding]; other site
596154000250	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000251	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154000252	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154000253	active site
596154000254	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154000255	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154000256	enoyl-CoA hydratase; Provisional; Region: PRK09245
596154000257	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154000258	substrate binding site [chemical binding]; other site
596154000259	oxyanion hole (OAH) forming residues; other site
596154000260	trimer interface [polypeptide binding]; other site
596154000261	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
596154000262	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
596154000263	septum formation inhibitor; Reviewed; Region: PRK01973
596154000264	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
596154000265	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
596154000266	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
596154000267	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
596154000268	Switch I; other site
596154000269	Switch II; other site
596154000270	cell division topological specificity factor MinE; Provisional; Region: PRK13989
596154000271	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154000272	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154000273	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
596154000274	putative effector binding pocket; other site
596154000275	putative dimerization interface [polypeptide binding]; other site
596154000276	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000277	galactonate dehydratase; Provisional; Region: PRK14017
596154000278	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
596154000279	active site pocket [active]
596154000280	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
596154000281	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
596154000282	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154000283	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154000284	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
596154000285	Ligand Binding Site [chemical binding]; other site
596154000286	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
596154000287	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
596154000288	active site
596154000289	metal binding site [ion binding]; metal-binding site
596154000290	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154000291	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154000292	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
596154000293	substrate binding pocket [chemical binding]; other site
596154000294	dimerization interface [polypeptide binding]; other site
596154000295	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
596154000296	active site
596154000297	substrate-binding site [chemical binding]; other site
596154000298	metal-binding site [ion binding]
596154000299	GTP binding site [chemical binding]; other site
596154000300	threonine dehydratase; Provisional; Region: PRK07334
596154000301	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
596154000302	tetramer interface [polypeptide binding]; other site
596154000303	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154000304	catalytic residue [active]
596154000305	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
596154000306	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
596154000307	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154000308	active site
596154000309	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
596154000310	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
596154000311	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
596154000312	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
596154000313	Soluble P-type ATPase [General function prediction only]; Region: COG4087
596154000314	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
596154000315	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
596154000316	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
596154000317	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
596154000318	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154000319	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448
596154000320	putative dimerization interface [polypeptide binding]; other site
596154000321	putative substrate binding pocket [chemical binding]; other site
596154000322	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154000323	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154000324	active site
596154000325	Cupin domain; Region: Cupin_2; pfam07883
596154000326	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154000327	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
596154000328	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
596154000329	ATP binding site [chemical binding]; other site
596154000330	putative Mg++ binding site [ion binding]; other site
596154000331	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
596154000332	nucleotide binding region [chemical binding]; other site
596154000333	ATP-binding site [chemical binding]; other site
596154000334	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
596154000335	HRDC domain; Region: HRDC; pfam00570
596154000336	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
596154000337	FeS/SAM binding site; other site
596154000338	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
596154000339	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
596154000340	ATP cone domain; Region: ATP-cone; pfam03477
596154000341	Class III ribonucleotide reductase; Region: RNR_III; cd01675
596154000342	effector binding site; other site
596154000343	active site
596154000344	Zn binding site [ion binding]; other site
596154000345	PAS fold; Region: PAS_4; pfam08448
596154000346	PAS domain; Region: PAS_9; pfam13426
596154000347	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154000348	putative active site [active]
596154000349	heme pocket [chemical binding]; other site
596154000350	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154000351	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154000352	metal binding site [ion binding]; metal-binding site
596154000353	active site
596154000354	I-site; other site
596154000355	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
596154000356	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
596154000357	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
596154000358	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
596154000359	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
596154000360	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
596154000361	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154000362	Walker A motif; other site
596154000363	ATP binding site [chemical binding]; other site
596154000364	Walker B motif; other site
596154000365	arginine finger; other site
596154000366	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
596154000367	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
596154000368	heme-binding site [chemical binding]; other site
596154000369	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
596154000370	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
596154000371	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
596154000372	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000373	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
596154000374	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154000375	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
596154000376	acyl-activating enzyme (AAE) consensus motif; other site
596154000377	acyl-activating enzyme (AAE) consensus motif; other site
596154000378	putative AMP binding site [chemical binding]; other site
596154000379	putative active site [active]
596154000380	putative CoA binding site [chemical binding]; other site
596154000381	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000382	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
596154000383	CoenzymeA binding site [chemical binding]; other site
596154000384	subunit interaction site [polypeptide binding]; other site
596154000385	PHB binding site; other site
596154000386	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000387	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000388	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154000389	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154000390	active site
596154000391	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154000392	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
596154000393	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
596154000394	acyl-activating enzyme (AAE) consensus motif; other site
596154000395	acyl-activating enzyme (AAE) consensus motif; other site
596154000396	putative AMP binding site [chemical binding]; other site
596154000397	putative active site [active]
596154000398	putative CoA binding site [chemical binding]; other site
596154000399	CoA binding site [chemical binding]; other site
596154000400	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
596154000401	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
596154000402	dimer interface [polypeptide binding]; other site
596154000403	active site
596154000404	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
596154000405	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154000406	NAD(P) binding site [chemical binding]; other site
596154000407	active site
596154000408	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000409	short chain dehydrogenase; Provisional; Region: PRK07576
596154000410	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
596154000411	NAD(P) binding site [chemical binding]; other site
596154000412	substrate binding site [chemical binding]; other site
596154000413	homotetramer interface [polypeptide binding]; other site
596154000414	active site
596154000415	homodimer interface [polypeptide binding]; other site
596154000416	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
596154000417	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154000418	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154000419	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154000420	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154000421	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
596154000422	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
596154000423	DUF35 OB-fold domain; Region: DUF35; pfam01796
596154000424	thiolase; Provisional; Region: PRK06158
596154000425	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
596154000426	active site
596154000427	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154000428	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154000429	active site
596154000430	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154000431	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
596154000432	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
596154000433	acyl-activating enzyme (AAE) consensus motif; other site
596154000434	acyl-activating enzyme (AAE) consensus motif; other site
596154000435	putative AMP binding site [chemical binding]; other site
596154000436	putative active site [active]
596154000437	putative CoA binding site [chemical binding]; other site
596154000438	enoyl-CoA hydratase; Region: PLN02864
596154000439	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
596154000440	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
596154000441	dimer interaction site [polypeptide binding]; other site
596154000442	substrate-binding tunnel; other site
596154000443	active site
596154000444	catalytic site [active]
596154000445	substrate binding site [chemical binding]; other site
596154000446	short chain dehydrogenase; Provisional; Region: PRK07791
596154000447	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154000448	NAD(P) binding site [chemical binding]; other site
596154000449	active site
596154000450	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000451	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
596154000452	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
596154000453	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154000454	Major Facilitator Superfamily; Region: MFS_1; pfam07690
596154000455	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
596154000456	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000457	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
596154000458	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154000459	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154000460	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154000461	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154000462	active site
596154000463	Uncharacterized conserved protein [Function unknown]; Region: COG3777
596154000464	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
596154000465	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
596154000466	active site 2 [active]
596154000467	active site 1 [active]
596154000468	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
596154000469	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154000470	NAD(P) binding site [chemical binding]; other site
596154000471	active site
596154000472	enoyl-CoA hydratase; Region: PLN02864
596154000473	Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452
596154000474	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
596154000475	dimer interaction site [polypeptide binding]; other site
596154000476	substrate-binding tunnel; other site
596154000477	active site
596154000478	catalytic site [active]
596154000479	substrate binding site [chemical binding]; other site
596154000480	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
596154000481	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154000482	substrate binding site [chemical binding]; other site
596154000483	oxyanion hole (OAH) forming residues; other site
596154000484	trimer interface [polypeptide binding]; other site
596154000485	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
596154000486	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
596154000487	Coenzyme A transferase; Region: CoA_trans; cl17247
596154000488	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
596154000489	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
596154000490	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
596154000491	dimer interface [polypeptide binding]; other site
596154000492	active site
596154000493	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154000494	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154000495	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
596154000496	putative effector binding pocket; other site
596154000497	dimerization interface [polypeptide binding]; other site
596154000498	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154000499	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154000500	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
596154000501	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
596154000502	NAD(P) binding site [chemical binding]; other site
596154000503	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000504	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
596154000505	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154000506	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
596154000507	dimerization interface [polypeptide binding]; other site
596154000508	substrate binding pocket [chemical binding]; other site
596154000509	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000510	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
596154000511	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
596154000512	metal binding site [ion binding]; metal-binding site
596154000513	putative dimer interface [polypeptide binding]; other site
596154000514	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000515	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
596154000516	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154000517	acyl-activating enzyme (AAE) consensus motif; other site
596154000518	AMP binding site [chemical binding]; other site
596154000519	active site
596154000520	CoA binding site [chemical binding]; other site
596154000521	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000522	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000523	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
596154000524	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
596154000525	metal binding site [ion binding]; metal-binding site
596154000526	putative dimer interface [polypeptide binding]; other site
596154000527	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
596154000528	DUF35 OB-fold domain; Region: DUF35; pfam01796
596154000529	thiolase; Provisional; Region: PRK06158
596154000530	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
596154000531	active site
596154000532	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154000533	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154000534	active site
596154000535	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
596154000536	CoenzymeA binding site [chemical binding]; other site
596154000537	subunit interaction site [polypeptide binding]; other site
596154000538	PHB binding site; other site
596154000539	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154000540	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
596154000541	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154000542	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
596154000543	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154000544	NAD(P) binding site [chemical binding]; other site
596154000545	active site
596154000546	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154000547	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154000548	active site
596154000549	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
596154000550	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154000551	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154000552	active site
596154000553	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154000554	enoyl-CoA hydratase; Provisional; Region: PRK07468
596154000555	substrate binding site [chemical binding]; other site
596154000556	oxyanion hole (OAH) forming residues; other site
596154000557	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
596154000558	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
596154000559	ATP-grasp domain; Region: ATP-grasp_4; cl17255
596154000560	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
596154000561	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
596154000562	carboxyltransferase (CT) interaction site; other site
596154000563	biotinylation site [posttranslational modification]; other site
596154000564	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
596154000565	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000566	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154000567	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154000568	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154000569	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154000570	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
596154000571	putative dimerization interface [polypeptide binding]; other site
596154000572	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154000573	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154000574	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154000575	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154000576	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
596154000577	putative dimerization interface [polypeptide binding]; other site
596154000578	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000579	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154000580	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154000581	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
596154000582	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
596154000583	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
596154000584	NAD(P) binding site [chemical binding]; other site
596154000585	Predicted membrane protein [Function unknown]; Region: COG4125
596154000586	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
596154000587	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
596154000588	SdiA-regulated; Region: SdiA-regulated; pfam06977
596154000589	SdiA-regulated; Region: SdiA-regulated; cd09971
596154000590	putative active site [active]
596154000591	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
596154000592	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
596154000593	substrate binding pocket [chemical binding]; other site
596154000594	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
596154000595	B12 binding site [chemical binding]; other site
596154000596	cobalt ligand [ion binding]; other site
596154000597	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
596154000598	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
596154000599	CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865
596154000600	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
596154000601	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442
596154000602	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
596154000603	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
596154000604	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
596154000605	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
596154000606	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
596154000607	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
596154000608	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
596154000609	Transposase; Region: HTH_Tnp_1; pfam01527
596154000610	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
596154000611	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
596154000612	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154000613	Walker A motif; other site
596154000614	ATP binding site [chemical binding]; other site
596154000615	Walker B motif; other site
596154000616	arginine finger; other site
596154000617	shikimate kinase; Reviewed; Region: aroK; PRK00131
596154000618	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
596154000619	ADP binding site [chemical binding]; other site
596154000620	magnesium binding site [ion binding]; other site
596154000621	putative shikimate binding site; other site
596154000622	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
596154000623	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
596154000624	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
596154000625	FAD binding pocket [chemical binding]; other site
596154000626	FAD binding motif [chemical binding]; other site
596154000627	phosphate binding motif [ion binding]; other site
596154000628	beta-alpha-beta structure motif; other site
596154000629	NAD binding pocket [chemical binding]; other site
596154000630	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330
596154000631	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154000632	putative ligand binding site [chemical binding]; other site
596154000633	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
596154000634	TM-ABC transporter signature motif; other site
596154000635	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
596154000636	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
596154000637	TM-ABC transporter signature motif; other site
596154000638	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
596154000639	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
596154000640	Walker A/P-loop; other site
596154000641	ATP binding site [chemical binding]; other site
596154000642	Q-loop/lid; other site
596154000643	ABC transporter signature motif; other site
596154000644	Walker B; other site
596154000645	D-loop; other site
596154000646	H-loop/switch region; other site
596154000647	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
596154000648	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
596154000649	Walker A/P-loop; other site
596154000650	ATP binding site [chemical binding]; other site
596154000651	Q-loop/lid; other site
596154000652	ABC transporter signature motif; other site
596154000653	Walker B; other site
596154000654	D-loop; other site
596154000655	H-loop/switch region; other site
596154000656	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
596154000657	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
596154000658	active site
596154000659	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
596154000660	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
596154000661	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
596154000662	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
596154000663	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
596154000664	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
596154000665	Nitrogen regulatory protein P-II; Region: P-II; smart00938
596154000666	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
596154000667	Transposase; Region: HTH_Tnp_1; cl17663
596154000668	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
596154000669	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154000670	Walker A motif; other site
596154000671	ATP binding site [chemical binding]; other site
596154000672	Walker B motif; other site
596154000673	arginine finger; other site
596154000674	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
596154000675	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
596154000676	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
596154000677	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
596154000678	SCP-2 sterol transfer family; Region: SCP2; cl01225
596154000679	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
596154000680	Putative ammonia monooxygenase; Region: AmoA; pfam05145
596154000681	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
596154000682	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154000683	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
596154000684	active site
596154000685	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000686	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
596154000687	CoA binding domain; Region: CoA_binding_2; pfam13380
596154000688	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
596154000689	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
596154000690	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
596154000691	FAD binding domain; Region: FAD_binding_4; pfam01565
596154000692	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
596154000693	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
596154000694	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
596154000695	Cysteine-rich domain; Region: CCG; pfam02754
596154000696	Cysteine-rich domain; Region: CCG; pfam02754
596154000697	ProQ/FINO family; Region: ProQ; smart00945
596154000698	putative RNA binding sites [nucleotide binding]; other site
596154000699	EamA-like transporter family; Region: EamA; pfam00892
596154000700	lysophospholipid transporter LplT; Provisional; Region: PRK11195
596154000701	alanine racemase; Reviewed; Region: dadX; PRK03646
596154000702	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
596154000703	active site
596154000704	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
596154000705	substrate binding site [chemical binding]; other site
596154000706	catalytic residues [active]
596154000707	dimer interface [polypeptide binding]; other site
596154000708	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
596154000709	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
596154000710	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
596154000711	C-terminal domain interface [polypeptide binding]; other site
596154000712	GSH binding site (G-site) [chemical binding]; other site
596154000713	dimer interface [polypeptide binding]; other site
596154000714	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
596154000715	dimer interface [polypeptide binding]; other site
596154000716	N-terminal domain interface [polypeptide binding]; other site
596154000717	substrate binding pocket (H-site) [chemical binding]; other site
596154000718	DNA repair protein RadA; Provisional; Region: PRK11823
596154000719	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
596154000720	Walker A motif/ATP binding site; other site
596154000721	ATP binding site [chemical binding]; other site
596154000722	Walker B motif; other site
596154000723	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
596154000724	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000725	putative amidase; Provisional; Region: PRK06169
596154000726	Amidase; Region: Amidase; pfam01425
596154000727	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
596154000728	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
596154000729	homodimer interface [polypeptide binding]; other site
596154000730	substrate-cofactor binding pocket; other site
596154000731	catalytic residue [active]
596154000732	Zinc-finger domain; Region: zf-CHCC; cl01821
596154000733	O-Antigen ligase; Region: Wzy_C; pfam04932
596154000734	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
596154000735	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
596154000736	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
596154000737	putative ADP-binding pocket [chemical binding]; other site
596154000738	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
596154000739	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
596154000740	active site
596154000741	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
596154000742	Nitronate monooxygenase; Region: NMO; pfam03060
596154000743	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
596154000744	FMN binding site [chemical binding]; other site
596154000745	substrate binding site [chemical binding]; other site
596154000746	putative catalytic residue [active]
596154000747	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154000748	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154000749	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154000750	dimerization interface [polypeptide binding]; other site
596154000751	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154000752	putative substrate translocation pore; other site
596154000753	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
596154000754	MOSC domain; Region: MOSC; pfam03473
596154000755	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
596154000756	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
596154000757	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
596154000758	putative hydrophobic ligand binding site [chemical binding]; other site
596154000759	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
596154000760	active site
596154000761	catalytic site [active]
596154000762	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000763	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154000764	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154000765	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154000766	dimerization interface [polypeptide binding]; other site
596154000767	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154000768	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154000769	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
596154000770	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
596154000771	dimerization interface [polypeptide binding]; other site
596154000772	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154000773	dimer interface [polypeptide binding]; other site
596154000774	phosphorylation site [posttranslational modification]
596154000775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154000776	ATP binding site [chemical binding]; other site
596154000777	Mg2+ binding site [ion binding]; other site
596154000778	G-X-G motif; other site
596154000779	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
596154000780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154000781	active site
596154000782	phosphorylation site [posttranslational modification]
596154000783	intermolecular recognition site; other site
596154000784	dimerization interface [polypeptide binding]; other site
596154000785	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
596154000786	DNA binding site [nucleotide binding]
596154000787	AmpG-like permease; Region: 2A0125; TIGR00901
596154000788	Cupin domain; Region: Cupin_2; cl17218
596154000789	Peptidase family M48; Region: Peptidase_M48; pfam01435
596154000790	Transcriptional regulators [Transcription]; Region: GntR; COG1802
596154000791	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154000792	DNA-binding site [nucleotide binding]; DNA binding site
596154000793	FCD domain; Region: FCD; pfam07729
596154000794	Activator of aromatic catabolism; Region: XylR_N; pfam06505
596154000795	V4R domain; Region: V4R; pfam02830
596154000796	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
596154000797	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154000798	Walker A motif; other site
596154000799	ATP binding site [chemical binding]; other site
596154000800	Walker B motif; other site
596154000801	arginine finger; other site
596154000802	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
596154000803	Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099
596154000804	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
596154000805	dimerization interface [polypeptide binding]; other site
596154000806	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
596154000807	Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
596154000808	dimerization interface [polypeptide binding]; other site
596154000809	putative path to active site cavity [active]
596154000810	diiron center [ion binding]; other site
596154000811	Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663
596154000812	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
596154000813	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
596154000814	catalytic loop [active]
596154000815	iron binding site [ion binding]; other site
596154000816	Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211
596154000817	FAD binding pocket [chemical binding]; other site
596154000818	FAD binding motif [chemical binding]; other site
596154000819	phosphate binding motif [ion binding]; other site
596154000820	beta-alpha-beta structure motif; other site
596154000821	NAD binding pocket [chemical binding]; other site
596154000822	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
596154000823	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
596154000824	catalytic loop [active]
596154000825	iron binding site [ion binding]; other site
596154000826	catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
596154000827	N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265
596154000828	tetramer interface [polypeptide binding]; other site
596154000829	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
596154000830	active site
596154000831	metal binding site [ion binding]; metal-binding site
596154000832	Domain of unknown function (DUF336); Region: DUF336; pfam03928
596154000833	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
596154000834	2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216
596154000835	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
596154000836	NAD binding site [chemical binding]; other site
596154000837	catalytic residues [active]
596154000838	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
596154000839	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
596154000840	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
596154000841	acetaldehyde dehydrogenase; Validated; Region: PRK08300
596154000842	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
596154000843	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
596154000844	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
596154000845	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
596154000846	active site
596154000847	catalytic residues [active]
596154000848	metal binding site [ion binding]; metal-binding site
596154000849	DmpG-like communication domain; Region: DmpG_comm; pfam07836
596154000850	4-oxalocrotonate decarboxylase; Region: catechol_dmpH; TIGR03218
596154000851	Tripartite tricarboxylate transporter family receptor; Region: TctC; pfam03401
596154000852	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
596154000853	active site 1 [active]
596154000854	dimer interface [polypeptide binding]; other site
596154000855	hexamer interface [polypeptide binding]; other site
596154000856	active site 2 [active]
596154000857	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
596154000858	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154000859	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
596154000860	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154000861	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000862	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
596154000863	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
596154000864	active site
596154000865	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000866	hypothetical protein; Validated; Region: PRK06201
596154000867	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
596154000868	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
596154000869	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
596154000870	ligand binding site [chemical binding]; other site
596154000871	NAD binding site [chemical binding]; other site
596154000872	dimerization interface [polypeptide binding]; other site
596154000873	catalytic site [active]
596154000874	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000875	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000876	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
596154000877	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
596154000878	active site
596154000879	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
596154000880	Strictosidine synthase; Region: Str_synth; pfam03088
596154000881	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000882	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
596154000883	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
596154000884	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
596154000885	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
596154000886	NAD(P) binding site [chemical binding]; other site
596154000887	catalytic residues [active]
596154000888	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154000889	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
596154000890	putative Zn2+ binding site [ion binding]; other site
596154000891	putative DNA binding site [nucleotide binding]; other site
596154000892	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154000893	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
596154000894	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
596154000895	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
596154000896	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154000897	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
596154000898	TM-ABC transporter signature motif; other site
596154000899	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
596154000900	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
596154000901	TM-ABC transporter signature motif; other site
596154000902	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
596154000903	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
596154000904	Walker A/P-loop; other site
596154000905	ATP binding site [chemical binding]; other site
596154000906	Q-loop/lid; other site
596154000907	ABC transporter signature motif; other site
596154000908	Walker B; other site
596154000909	D-loop; other site
596154000910	H-loop/switch region; other site
596154000911	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
596154000912	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
596154000913	Walker A/P-loop; other site
596154000914	ATP binding site [chemical binding]; other site
596154000915	Q-loop/lid; other site
596154000916	ABC transporter signature motif; other site
596154000917	Walker B; other site
596154000918	D-loop; other site
596154000919	H-loop/switch region; other site
596154000920	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
596154000921	Amidohydrolase; Region: Amidohydro_2; pfam04909
596154000922	Transcriptional regulators [Transcription]; Region: GntR; COG1802
596154000923	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154000924	DNA-binding site [nucleotide binding]; DNA binding site
596154000925	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154000926	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
596154000927	active site
596154000928	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154000929	short chain dehydrogenase; Provisional; Region: PRK06949
596154000930	NAD(P) binding site [chemical binding]; other site
596154000931	active site
596154000932	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
596154000933	Phosphotransferase enzyme family; Region: APH; pfam01636
596154000934	putative active site [active]
596154000935	putative substrate binding site [chemical binding]; other site
596154000936	ATP binding site [chemical binding]; other site
596154000937	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
596154000938	putative active site [active]
596154000939	putative catalytic site [active]
596154000940	putative DNA binding site [nucleotide binding]; other site
596154000941	putative phosphate binding site [ion binding]; other site
596154000942	metal binding site A [ion binding]; metal-binding site
596154000943	putative AP binding site [nucleotide binding]; other site
596154000944	putative metal binding site B [ion binding]; other site
596154000945	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
596154000946	active site
596154000947	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
596154000948	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
596154000949	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
596154000950	GatB domain; Region: GatB_Yqey; smart00845
596154000951	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
596154000952	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
596154000953	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
596154000954	rod shape-determining protein MreB; Provisional; Region: PRK13927
596154000955	MreB and similar proteins; Region: MreB_like; cd10225
596154000956	nucleotide binding site [chemical binding]; other site
596154000957	Mg binding site [ion binding]; other site
596154000958	putative protofilament interaction site [polypeptide binding]; other site
596154000959	RodZ interaction site [polypeptide binding]; other site
596154000960	rod shape-determining protein MreC; Provisional; Region: PRK13922
596154000961	rod shape-determining protein MreC; Region: MreC; pfam04085
596154000962	rod shape-determining protein MreD; Region: MreD; cl01087
596154000963	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
596154000964	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
596154000965	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
596154000966	Arginase family; Region: Arginase; cd09989
596154000967	active site
596154000968	Mn binding site [ion binding]; other site
596154000969	oligomer interface [polypeptide binding]; other site
596154000970	hypothetical protein; Provisional; Region: PRK10621
596154000971	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
596154000972	choline dehydrogenase; Validated; Region: PRK02106
596154000973	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
596154000974	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
596154000975	Permease; Region: Permease; pfam02405
596154000976	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
596154000977	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
596154000978	Walker A/P-loop; other site
596154000979	ATP binding site [chemical binding]; other site
596154000980	Q-loop/lid; other site
596154000981	ABC transporter signature motif; other site
596154000982	Walker B; other site
596154000983	D-loop; other site
596154000984	H-loop/switch region; other site
596154000985	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
596154000986	mce related protein; Region: MCE; pfam02470
596154000987	Protein of unknown function (DUF330); Region: DUF330; cl01135
596154000988	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154000989	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154000990	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
596154000991	putative dimerization interface [polypeptide binding]; other site
596154000992	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
596154000993	substrate binding site [chemical binding]; other site
596154000994	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
596154000995	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
596154000996	substrate binding site [chemical binding]; other site
596154000997	ligand binding site [chemical binding]; other site
596154000998	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154000999	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
596154001000	MarC family integral membrane protein; Region: MarC; cl00919
596154001001	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
596154001002	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
596154001003	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
596154001004	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154001005	putative substrate translocation pore; other site
596154001006	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154001007	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
596154001008	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
596154001009	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
596154001010	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
596154001011	MarR family; Region: MarR; pfam01047
596154001012	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
596154001013	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
596154001014	oligomer interface [polypeptide binding]; other site
596154001015	metal binding site [ion binding]; metal-binding site
596154001016	metal binding site [ion binding]; metal-binding site
596154001017	putative Cl binding site [ion binding]; other site
596154001018	aspartate ring; other site
596154001019	basic sphincter; other site
596154001020	hydrophobic gate; other site
596154001021	periplasmic entrance; other site
596154001022	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
596154001023	dimer interface [polypeptide binding]; other site
596154001024	allosteric magnesium binding site [ion binding]; other site
596154001025	active site
596154001026	aspartate-rich active site metal binding site; other site
596154001027	Schiff base residues; other site
596154001028	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
596154001029	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
596154001030	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
596154001031	dimer interface [polypeptide binding]; other site
596154001032	[2Fe-2S] cluster binding site [ion binding]; other site
596154001033	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
596154001034	Serine hydrolase; Region: Ser_hydrolase; cl17834
596154001035	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
596154001036	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
596154001037	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
596154001038	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
596154001039	S17 interaction site [polypeptide binding]; other site
596154001040	S8 interaction site; other site
596154001041	16S rRNA interaction site [nucleotide binding]; other site
596154001042	streptomycin interaction site [chemical binding]; other site
596154001043	23S rRNA interaction site [nucleotide binding]; other site
596154001044	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
596154001045	30S ribosomal protein S7; Validated; Region: PRK05302
596154001046	elongation factor G; Reviewed; Region: PRK00007
596154001047	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
596154001048	G1 box; other site
596154001049	putative GEF interaction site [polypeptide binding]; other site
596154001050	GTP/Mg2+ binding site [chemical binding]; other site
596154001051	Switch I region; other site
596154001052	G2 box; other site
596154001053	G3 box; other site
596154001054	Switch II region; other site
596154001055	G4 box; other site
596154001056	G5 box; other site
596154001057	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
596154001058	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
596154001059	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
596154001060	elongation factor Tu; Reviewed; Region: PRK00049
596154001061	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
596154001062	G1 box; other site
596154001063	GEF interaction site [polypeptide binding]; other site
596154001064	GTP/Mg2+ binding site [chemical binding]; other site
596154001065	Switch I region; other site
596154001066	G2 box; other site
596154001067	G3 box; other site
596154001068	Switch II region; other site
596154001069	G4 box; other site
596154001070	G5 box; other site
596154001071	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
596154001072	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
596154001073	Antibiotic Binding Site [chemical binding]; other site
596154001074	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
596154001075	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
596154001076	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
596154001077	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
596154001078	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
596154001079	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
596154001080	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
596154001081	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
596154001082	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
596154001083	putative translocon binding site; other site
596154001084	protein-rRNA interface [nucleotide binding]; other site
596154001085	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
596154001086	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
596154001087	G-X-X-G motif; other site
596154001088	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
596154001089	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
596154001090	23S rRNA interface [nucleotide binding]; other site
596154001091	5S rRNA interface [nucleotide binding]; other site
596154001092	putative antibiotic binding site [chemical binding]; other site
596154001093	L25 interface [polypeptide binding]; other site
596154001094	L27 interface [polypeptide binding]; other site
596154001095	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
596154001096	23S rRNA interface [nucleotide binding]; other site
596154001097	putative translocon interaction site; other site
596154001098	signal recognition particle (SRP54) interaction site; other site
596154001099	L23 interface [polypeptide binding]; other site
596154001100	trigger factor interaction site; other site
596154001101	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
596154001102	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
596154001103	catalytic triad [active]
596154001104	dimer interface [polypeptide binding]; other site
596154001105	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
596154001106	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
596154001107	Coenzyme A binding pocket [chemical binding]; other site
596154001108	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
596154001109	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
596154001110	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
596154001111	catalytic residues [active]
596154001112	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
596154001113	active pocket/dimerization site; other site
596154001114	active site
596154001115	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
596154001116	dimerization domain swap beta strand [polypeptide binding]; other site
596154001117	regulatory protein interface [polypeptide binding]; other site
596154001118	active site
596154001119	regulatory phosphorylation site [posttranslational modification]; other site
596154001120	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
596154001121	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
596154001122	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
596154001123	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
596154001124	lipoyl synthase; Provisional; Region: PRK05481
596154001125	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
596154001126	FeS/SAM binding site; other site
596154001127	lipoate-protein ligase B; Provisional; Region: PRK14346
596154001128	Protein of unknown function (DUF493); Region: DUF493; cl01102
596154001129	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
596154001130	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
596154001131	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
596154001132	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
596154001133	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
596154001134	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
596154001135	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
596154001136	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
596154001137	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
596154001138	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
596154001139	beta subunit interaction interface [polypeptide binding]; other site
596154001140	Walker A motif; other site
596154001141	ATP binding site [chemical binding]; other site
596154001142	Walker B motif; other site
596154001143	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
596154001144	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
596154001145	core domain interface [polypeptide binding]; other site
596154001146	delta subunit interface [polypeptide binding]; other site
596154001147	epsilon subunit interface [polypeptide binding]; other site
596154001148	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
596154001149	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
596154001150	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
596154001151	alpha subunit interaction interface [polypeptide binding]; other site
596154001152	Walker A motif; other site
596154001153	ATP binding site [chemical binding]; other site
596154001154	Walker B motif; other site
596154001155	inhibitor binding site; inhibition site
596154001156	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
596154001157	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
596154001158	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
596154001159	gamma subunit interface [polypeptide binding]; other site
596154001160	epsilon subunit interface [polypeptide binding]; other site
596154001161	LBP interface [polypeptide binding]; other site
596154001162	Transposase; Region: HTH_Tnp_1; pfam01527
596154001163	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
596154001164	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
596154001165	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
596154001166	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
596154001167	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
596154001168	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
596154001169	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
596154001170	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
596154001171	Repair protein; Region: Repair_PSII; pfam04536
596154001172	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
596154001173	Repair protein; Region: Repair_PSII; pfam04536
596154001174	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
596154001175	SnoaL-like domain; Region: SnoaL_3; pfam13474
596154001176	SnoaL-like domain; Region: SnoaL_2; pfam12680
596154001177	Protein of unknown function (DUF2946); Region: DUF2944; pfam11161
596154001178	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
596154001179	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
596154001180	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
596154001181	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
596154001182	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154001183	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
596154001184	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154001185	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
596154001186	elongation factor Tu; Reviewed; Region: PRK00049
596154001187	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
596154001188	G1 box; other site
596154001189	GEF interaction site [polypeptide binding]; other site
596154001190	GTP/Mg2+ binding site [chemical binding]; other site
596154001191	Switch I region; other site
596154001192	G2 box; other site
596154001193	G3 box; other site
596154001194	Switch II region; other site
596154001195	G4 box; other site
596154001196	G5 box; other site
596154001197	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
596154001198	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
596154001199	Antibiotic Binding Site [chemical binding]; other site
596154001200	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
596154001201	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
596154001202	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
596154001203	putative homodimer interface [polypeptide binding]; other site
596154001204	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
596154001205	heterodimer interface [polypeptide binding]; other site
596154001206	homodimer interface [polypeptide binding]; other site
596154001207	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
596154001208	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
596154001209	23S rRNA interface [nucleotide binding]; other site
596154001210	L7/L12 interface [polypeptide binding]; other site
596154001211	putative thiostrepton binding site; other site
596154001212	L25 interface [polypeptide binding]; other site
596154001213	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
596154001214	mRNA/rRNA interface [nucleotide binding]; other site
596154001215	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
596154001216	23S rRNA interface [nucleotide binding]; other site
596154001217	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
596154001218	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
596154001219	peripheral dimer interface [polypeptide binding]; other site
596154001220	core dimer interface [polypeptide binding]; other site
596154001221	L10 interface [polypeptide binding]; other site
596154001222	L11 interface [polypeptide binding]; other site
596154001223	putative EF-Tu interaction site [polypeptide binding]; other site
596154001224	putative EF-G interaction site [polypeptide binding]; other site
596154001225	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
596154001226	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
596154001227	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
596154001228	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
596154001229	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
596154001230	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
596154001231	RPB3 interaction site [polypeptide binding]; other site
596154001232	RPB1 interaction site [polypeptide binding]; other site
596154001233	RPB11 interaction site [polypeptide binding]; other site
596154001234	RPB10 interaction site [polypeptide binding]; other site
596154001235	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
596154001236	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
596154001237	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
596154001238	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
596154001239	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
596154001240	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
596154001241	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
596154001242	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
596154001243	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
596154001244	DNA binding site [nucleotide binding]
596154001245	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
596154001246	LemA family; Region: LemA; cl00742
596154001247	16S rRNA methyltransferase B; Provisional; Region: PRK10901
596154001248	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
596154001249	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154001250	S-adenosylmethionine binding site [chemical binding]; other site
596154001251	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
596154001252	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
596154001253	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
596154001254	dimerization interface [polypeptide binding]; other site
596154001255	PAS domain; Region: PAS; smart00091
596154001256	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154001257	dimer interface [polypeptide binding]; other site
596154001258	phosphorylation site [posttranslational modification]
596154001259	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154001260	ATP binding site [chemical binding]; other site
596154001261	Mg2+ binding site [ion binding]; other site
596154001262	G-X-G motif; other site
596154001263	Response regulator receiver domain; Region: Response_reg; pfam00072
596154001264	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154001265	active site
596154001266	phosphorylation site [posttranslational modification]
596154001267	intermolecular recognition site; other site
596154001268	dimerization interface [polypeptide binding]; other site
596154001269	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
596154001270	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
596154001271	putative transposase OrfB; Reviewed; Region: PHA02517
596154001272	HTH-like domain; Region: HTH_21; pfam13276
596154001273	Integrase core domain; Region: rve; pfam00665
596154001274	Integrase core domain; Region: rve_3; pfam13683
596154001275	Transposase; Region: HTH_Tnp_1; pfam01527
596154001276	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
596154001277	oligomerization interface [polypeptide binding]; other site
596154001278	AAA domain; Region: AAA_25; pfam13481
596154001279	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
596154001280	ATP binding site [chemical binding]; other site
596154001281	Walker B motif; other site
596154001282	CHC2 zinc finger; Region: zf-CHC2; cl17510
596154001283	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
596154001284	integrase; Provisional; Region: PRK09692
596154001285	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
596154001286	active site
596154001287	Int/Topo IB signature motif; other site
596154001288	Homeodomain-like domain; Region: HTH_23; pfam13384
596154001289	Winged helix-turn helix; Region: HTH_29; pfam13551
596154001290	DDE superfamily endonuclease; Region: DDE_3; pfam13358
596154001291	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
596154001292	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
596154001293	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
596154001294	putative NAD(P) binding site [chemical binding]; other site
596154001295	active site
596154001296	putative substrate binding site [chemical binding]; other site
596154001297	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
596154001298	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
596154001299	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
596154001300	Ligand binding site; other site
596154001301	Putative Catalytic site; other site
596154001302	DXD motif; other site
596154001303	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
596154001304	Predicted methyltransferases [General function prediction only]; Region: COG0313
596154001305	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
596154001306	putative SAM binding site [chemical binding]; other site
596154001307	putative homodimer interface [polypeptide binding]; other site
596154001308	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
596154001309	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
596154001310	dimer interface [polypeptide binding]; other site
596154001311	active site
596154001312	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
596154001313	BON domain; Region: BON; pfam04972
596154001314	BON domain; Region: BON; pfam04972
596154001315	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
596154001316	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
596154001317	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
596154001318	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
596154001319	Walker A motif; other site
596154001320	ATP binding site [chemical binding]; other site
596154001321	Walker B motif; other site
596154001322	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
596154001323	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
596154001324	ligand binding site [chemical binding]; other site
596154001325	flexible hinge region; other site
596154001326	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
596154001327	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
596154001328	Walker A motif; other site
596154001329	ATP binding site [chemical binding]; other site
596154001330	Walker B motif; other site
596154001331	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
596154001332	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
596154001333	catalytic residue [active]
596154001334	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
596154001335	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
596154001336	catalytic residue [active]
596154001337	bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355
596154001338	Protein of unknown function (DUF445); Region: DUF445; pfam04286
596154001339	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
596154001340	FAD binding domain; Region: FAD_binding_4; pfam01565
596154001341	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
596154001342	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154001343	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
596154001344	dimerization interface [polypeptide binding]; other site
596154001345	substrate binding pocket [chemical binding]; other site
596154001346	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
596154001347	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
596154001348	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
596154001349	putative active site [active]
596154001350	putative substrate binding site [chemical binding]; other site
596154001351	putative cosubstrate binding site; other site
596154001352	catalytic site [active]
596154001353	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
596154001354	PAS domain; Region: PAS_9; pfam13426
596154001355	putative active site [active]
596154001356	heme pocket [chemical binding]; other site
596154001357	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154001358	PAS fold; Region: PAS_3; pfam08447
596154001359	putative active site [active]
596154001360	heme pocket [chemical binding]; other site
596154001361	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154001362	PAS domain; Region: PAS_9; pfam13426
596154001363	putative active site [active]
596154001364	heme pocket [chemical binding]; other site
596154001365	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154001366	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154001367	metal binding site [ion binding]; metal-binding site
596154001368	active site
596154001369	I-site; other site
596154001370	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
596154001371	Protein of unknown function, DUF399; Region: DUF399; cl01139
596154001372	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
596154001373	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
596154001374	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
596154001375	active site
596154001376	dimer interface [polypeptide binding]; other site
596154001377	effector binding site; other site
596154001378	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
596154001379	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
596154001380	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
596154001381	dimerization interface [polypeptide binding]; other site
596154001382	GAF domain; Region: GAF; pfam01590
596154001383	Histidine kinase; Region: HisKA_3; pfam07730
596154001384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154001385	ATP binding site [chemical binding]; other site
596154001386	Mg2+ binding site [ion binding]; other site
596154001387	G-X-G motif; other site
596154001388	transcriptional regulator NarL; Provisional; Region: PRK10651
596154001389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154001390	active site
596154001391	phosphorylation site [posttranslational modification]
596154001392	intermolecular recognition site; other site
596154001393	dimerization interface [polypeptide binding]; other site
596154001394	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
596154001395	DNA binding residues [nucleotide binding]
596154001396	dimerization interface [polypeptide binding]; other site
596154001397	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
596154001398	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154001399	putative substrate translocation pore; other site
596154001400	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
596154001401	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
596154001402	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
596154001403	[4Fe-4S] binding site [ion binding]; other site
596154001404	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
596154001405	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
596154001406	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
596154001407	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
596154001408	molybdopterin cofactor binding site; other site
596154001409	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
596154001410	4Fe-4S binding domain; Region: Fer4; cl02805
596154001411	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
596154001412	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
596154001413	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
596154001414	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
596154001415	active site clefts [active]
596154001416	zinc binding site [ion binding]; other site
596154001417	dimer interface [polypeptide binding]; other site
596154001418	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
596154001419	putative FMN binding site [chemical binding]; other site
596154001420	Hemerythrin-like domain; Region: Hr-like; cd12108
596154001421	Fe binding site [ion binding]; other site
596154001422	Protein of unknown function (DUF3567); Region: DUF3567; pfam12091
596154001423	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
596154001424	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
596154001425	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
596154001426	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
596154001427	TPR repeat; Region: TPR_11; pfam13414
596154001428	binding surface
596154001429	TPR motif; other site
596154001430	TPR repeat; Region: TPR_11; pfam13414
596154001431	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
596154001432	binding surface
596154001433	TPR motif; other site
596154001434	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
596154001435	binding surface
596154001436	TPR motif; other site
596154001437	TPR repeat; Region: TPR_11; pfam13414
596154001438	TPR repeat; Region: TPR_11; pfam13414
596154001439	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
596154001440	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
596154001441	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
596154001442	putative [4Fe-4S] binding site [ion binding]; other site
596154001443	putative molybdopterin cofactor binding site [chemical binding]; other site
596154001444	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
596154001445	molybdopterin cofactor binding site; other site
596154001446	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154001447	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
596154001448	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154001449	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154001450	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
596154001451	putative active site [active]
596154001452	putative catalytic site [active]
596154001453	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154001454	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154001455	active site
596154001456	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
596154001457	putative active site [active]
596154001458	putative catalytic site [active]
596154001459	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
596154001460	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
596154001461	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154001462	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
596154001463	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154001464	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
596154001465	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
596154001466	metal binding site [ion binding]; metal-binding site
596154001467	putative dimer interface [polypeptide binding]; other site
596154001468	Acyl CoA binding protein; Region: ACBP; pfam00887
596154001469	acyl-CoA binding pocket [chemical binding]; other site
596154001470	CoA binding site [chemical binding]; other site
596154001471	Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720
596154001472	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
596154001473	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
596154001474	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154001475	S-adenosylmethionine binding site [chemical binding]; other site
596154001476	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
596154001477	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154001478	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154001479	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154001480	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
596154001481	acyl-activating enzyme (AAE) consensus motif; other site
596154001482	active site
596154001483	AMP binding site [chemical binding]; other site
596154001484	CoA binding site [chemical binding]; other site
596154001485	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
596154001486	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
596154001487	Walker A/P-loop; other site
596154001488	ATP binding site [chemical binding]; other site
596154001489	Q-loop/lid; other site
596154001490	ABC transporter signature motif; other site
596154001491	Walker B; other site
596154001492	D-loop; other site
596154001493	H-loop/switch region; other site
596154001494	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154001495	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
596154001496	putative ligand binding site [chemical binding]; other site
596154001497	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
596154001498	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
596154001499	TM-ABC transporter signature motif; other site
596154001500	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154001501	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
596154001502	TM-ABC transporter signature motif; other site
596154001503	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
596154001504	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
596154001505	Walker A/P-loop; other site
596154001506	ATP binding site [chemical binding]; other site
596154001507	Q-loop/lid; other site
596154001508	ABC transporter signature motif; other site
596154001509	Walker B; other site
596154001510	D-loop; other site
596154001511	H-loop/switch region; other site
596154001512	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
596154001513	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
596154001514	putative AMP binding site [chemical binding]; other site
596154001515	putative active site [active]
596154001516	putative CoA binding site [chemical binding]; other site
596154001517	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
596154001518	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154001519	Walker A motif; other site
596154001520	ATP binding site [chemical binding]; other site
596154001521	Walker B motif; other site
596154001522	arginine finger; other site
596154001523	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
596154001524	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
596154001525	ligand binding site [chemical binding]; other site
596154001526	flexible hinge region; other site
596154001527	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
596154001528	non-specific DNA interactions [nucleotide binding]; other site
596154001529	DNA binding site [nucleotide binding]
596154001530	sequence specific DNA binding site [nucleotide binding]; other site
596154001531	putative cAMP binding site [chemical binding]; other site
596154001532	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
596154001533	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
596154001534	RNA binding surface [nucleotide binding]; other site
596154001535	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
596154001536	active site
596154001537	heat shock protein 90; Provisional; Region: PRK05218
596154001538	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154001539	ATP binding site [chemical binding]; other site
596154001540	Mg2+ binding site [ion binding]; other site
596154001541	G-X-G motif; other site
596154001542	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154001543	serine/threonine protein kinase; Provisional; Region: PRK11768
596154001544	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
596154001545	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
596154001546	Catalytic domain of Protein Kinases; Region: PKc; cd00180
596154001547	active site
596154001548	ATP binding site [chemical binding]; other site
596154001549	substrate binding site [chemical binding]; other site
596154001550	activation loop (A-loop); other site
596154001551	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
596154001552	Ligand Binding Site [chemical binding]; other site
596154001553	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
596154001554	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
596154001555	active site
596154001556	metal binding site [ion binding]; metal-binding site
596154001557	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154001558	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154001559	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
596154001560	active site
596154001561	catalytic site [active]
596154001562	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
596154001563	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
596154001564	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
596154001565	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
596154001566	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
596154001567	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
596154001568	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
596154001569	active site
596154001570	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
596154001571	homotrimer interaction site [polypeptide binding]; other site
596154001572	putative active site [active]
596154001573	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154001574	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
596154001575	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154001576	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
596154001577	putative DNA binding site [nucleotide binding]; other site
596154001578	putative Zn2+ binding site [ion binding]; other site
596154001579	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154001580	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
596154001581	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
596154001582	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
596154001583	choline dehydrogenase; Validated; Region: PRK02106
596154001584	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
596154001585	ABC-2 type transporter; Region: ABC2_membrane; cl17235
596154001586	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
596154001587	nodulation ABC transporter NodI; Provisional; Region: PRK13537
596154001588	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154001589	Walker A/P-loop; other site
596154001590	ATP binding site [chemical binding]; other site
596154001591	Q-loop/lid; other site
596154001592	ABC transporter signature motif; other site
596154001593	Walker B; other site
596154001594	D-loop; other site
596154001595	H-loop/switch region; other site
596154001596	Tannase and feruloyl esterase; Region: Tannase; pfam07519
596154001597	AMP nucleosidase; Provisional; Region: PRK08292
596154001598	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
596154001599	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
596154001600	PAS fold; Region: PAS_4; pfam08448
596154001601	PAS domain S-box; Region: sensory_box; TIGR00229
596154001602	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154001603	putative active site [active]
596154001604	heme pocket [chemical binding]; other site
596154001605	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154001606	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154001607	metal binding site [ion binding]; metal-binding site
596154001608	active site
596154001609	I-site; other site
596154001610	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
596154001611	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
596154001612	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
596154001613	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
596154001614	putative active site [active]
596154001615	dimerization interface [polypeptide binding]; other site
596154001616	putative tRNAtyr binding site [nucleotide binding]; other site
596154001617	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154001618	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154001619	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
596154001620	dimerization interface [polypeptide binding]; other site
596154001621	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154001622	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154001623	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154001624	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
596154001625	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
596154001626	NADP binding site [chemical binding]; other site
596154001627	dimer interface [polypeptide binding]; other site
596154001628	acyl-CoA synthetase; Validated; Region: PRK06188
596154001629	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154001630	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
596154001631	acyl-activating enzyme (AAE) consensus motif; other site
596154001632	acyl-activating enzyme (AAE) consensus motif; other site
596154001633	putative AMP binding site [chemical binding]; other site
596154001634	putative active site [active]
596154001635	putative CoA binding site [chemical binding]; other site
596154001636	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
596154001637	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
596154001638	PhoH-like protein; Region: PhoH; pfam02562
596154001639	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
596154001640	RuvA N terminal domain; Region: RuvA_N; pfam01330
596154001641	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
596154001642	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
596154001643	nucleotide binding site [chemical binding]; other site
596154001644	putative NEF/HSP70 interaction site [polypeptide binding]; other site
596154001645	SBD interface [polypeptide binding]; other site
596154001646	DNA-K related protein; Region: DUF3731; pfam12531
596154001647	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
596154001648	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
596154001649	nucleotide binding site [chemical binding]; other site
596154001650	putative NEF/HSP70 interaction site [polypeptide binding]; other site
596154001651	SBD interface [polypeptide binding]; other site
596154001652	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
596154001653	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
596154001654	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154001655	Walker A motif; other site
596154001656	ATP binding site [chemical binding]; other site
596154001657	Walker B motif; other site
596154001658	arginine finger; other site
596154001659	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
596154001660	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
596154001661	MgtC family; Region: MgtC; pfam02308
596154001662	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
596154001663	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
596154001664	dimer interface [polypeptide binding]; other site
596154001665	active site
596154001666	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
596154001667	substrate binding site [chemical binding]; other site
596154001668	catalytic residue [active]
596154001669	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
596154001670	catalytic core [active]
596154001671	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
596154001672	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
596154001673	Ligand Binding Site [chemical binding]; other site
596154001674	Dihydroneopterin aldolase; Region: FolB; smart00905
596154001675	active site
596154001676	Dihydroneopterin aldolase; Region: FolB; smart00905
596154001677	active site
596154001678	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154001679	short chain dehydrogenase; Provisional; Region: PRK09134
596154001680	NAD(P) binding site [chemical binding]; other site
596154001681	active site
596154001682	Uncharacterized conserved protein [Function unknown]; Region: COG1565
596154001683	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
596154001684	dimer interface [polypeptide binding]; other site
596154001685	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
596154001686	metal binding site [ion binding]; metal-binding site
596154001687	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
596154001688	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
596154001689	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
596154001690	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
596154001691	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
596154001692	active site
596154001693	homotetramer interface [polypeptide binding]; other site
596154001694	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
596154001695	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
596154001696	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
596154001697	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
596154001698	active site
596154001699	motif I; other site
596154001700	motif II; other site
596154001701	thioredoxin 2; Provisional; Region: PRK10996
596154001702	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
596154001703	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
596154001704	catalytic residues [active]
596154001705	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
596154001706	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
596154001707	active site
596154001708	NTP binding site [chemical binding]; other site
596154001709	metal binding triad [ion binding]; metal-binding site
596154001710	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
596154001711	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
596154001712	Zn2+ binding site [ion binding]; other site
596154001713	Mg2+ binding site [ion binding]; other site
596154001714	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
596154001715	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154001716	Walker A motif; other site
596154001717	ATP binding site [chemical binding]; other site
596154001718	Walker B motif; other site
596154001719	arginine finger; other site
596154001720	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
596154001721	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
596154001722	Domain of unknown function (DUF4387); Region: DUF4387; pfam14330
596154001723	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154001724	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
596154001725	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
596154001726	putative active site [active]
596154001727	putative metal binding site [ion binding]; other site
596154001728	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
596154001729	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
596154001730	putative C-terminal domain interface [polypeptide binding]; other site
596154001731	putative GSH binding site (G-site) [chemical binding]; other site
596154001732	putative dimer interface [polypeptide binding]; other site
596154001733	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
596154001734	putative N-terminal domain interface [polypeptide binding]; other site
596154001735	putative dimer interface [polypeptide binding]; other site
596154001736	putative substrate binding pocket (H-site) [chemical binding]; other site
596154001737	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
596154001738	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
596154001739	lytic murein transglycosylase; Provisional; Region: PRK11619
596154001740	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
596154001741	N-acetyl-D-glucosamine binding site [chemical binding]; other site
596154001742	catalytic residue [active]
596154001743	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
596154001744	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
596154001745	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
596154001746	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
596154001747	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
596154001748	active site
596154001749	substrate binding site [chemical binding]; other site
596154001750	FMN binding site [chemical binding]; other site
596154001751	putative catalytic residues [active]
596154001752	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
596154001753	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
596154001754	N-terminal plug; other site
596154001755	ligand-binding site [chemical binding]; other site
596154001756	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
596154001757	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
596154001758	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154001759	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
596154001760	acyl-activating enzyme (AAE) consensus motif; other site
596154001761	putative AMP binding site [chemical binding]; other site
596154001762	putative active site [active]
596154001763	putative CoA binding site [chemical binding]; other site
596154001764	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
596154001765	PGAP1-like protein; Region: PGAP1; pfam07819
596154001766	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
596154001767	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
596154001768	dimer interface [polypeptide binding]; other site
596154001769	active site
596154001770	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
596154001771	dimer interface [polypeptide binding]; other site
596154001772	active site 1 [active]
596154001773	active site 2 [active]
596154001774	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
596154001775	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
596154001776	putative active site [active]
596154001777	catalytic triad [active]
596154001778	putative dimer interface [polypeptide binding]; other site
596154001779	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
596154001780	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
596154001781	Transporter associated domain; Region: CorC_HlyC; smart01091
596154001782	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
596154001783	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
596154001784	Coenzyme A binding pocket [chemical binding]; other site
596154001785	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
596154001786	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
596154001787	AsnC family; Region: AsnC_trans_reg; pfam01037
596154001788	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
596154001789	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
596154001790	dimer interface [polypeptide binding]; other site
596154001791	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
596154001792	active site
596154001793	Fe binding site [ion binding]; other site
596154001794	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
596154001795	cofactor binding site; other site
596154001796	metal binding site [ion binding]; metal-binding site
596154001797	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
596154001798	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
596154001799	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
596154001800	tetramer interface [polypeptide binding]; other site
596154001801	TPP-binding site [chemical binding]; other site
596154001802	heterodimer interface [polypeptide binding]; other site
596154001803	phosphorylation loop region [posttranslational modification]
596154001804	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
596154001805	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
596154001806	alpha subunit interface [polypeptide binding]; other site
596154001807	TPP binding site [chemical binding]; other site
596154001808	heterodimer interface [polypeptide binding]; other site
596154001809	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
596154001810	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
596154001811	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
596154001812	E3 interaction surface; other site
596154001813	lipoyl attachment site [posttranslational modification]; other site
596154001814	e3 binding domain; Region: E3_binding; pfam02817
596154001815	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
596154001816	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
596154001817	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
596154001818	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
596154001819	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
596154001820	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
596154001821	dimer interface [polypeptide binding]; other site
596154001822	motif 1; other site
596154001823	active site
596154001824	motif 2; other site
596154001825	motif 3; other site
596154001826	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
596154001827	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
596154001828	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
596154001829	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
596154001830	active site
596154001831	motif I; other site
596154001832	motif II; other site
596154001833	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
596154001834	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
596154001835	putative acyl-acceptor binding pocket; other site
596154001836	Protein of unknown function DUF45; Region: DUF45; pfam01863
596154001837	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
596154001838	active site residue [active]
596154001839	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
596154001840	BON domain; Region: BON; pfam04972
596154001841	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
596154001842	pantothenate kinase; Reviewed; Region: PRK13329
596154001843	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154001844	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154001845	Bacterial transcriptional repressor; Region: TetR; pfam13972
596154001846	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
596154001847	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
596154001848	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
596154001849	NAD binding site [chemical binding]; other site
596154001850	substrate binding site [chemical binding]; other site
596154001851	homodimer interface [polypeptide binding]; other site
596154001852	active site
596154001853	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
596154001854	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
596154001855	NADP binding site [chemical binding]; other site
596154001856	active site
596154001857	putative substrate binding site [chemical binding]; other site
596154001858	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
596154001859	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
596154001860	substrate binding site; other site
596154001861	tetramer interface; other site
596154001862	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
596154001863	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
596154001864	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
596154001865	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
596154001866	Ligand binding site; other site
596154001867	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
596154001868	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
596154001869	type II secretion system protein E; Region: type_II_gspE; TIGR02533
596154001870	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
596154001871	Walker A motif; other site
596154001872	ATP binding site [chemical binding]; other site
596154001873	Walker B motif; other site
596154001874	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
596154001875	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
596154001876	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
596154001877	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
596154001878	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
596154001879	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
596154001880	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
596154001881	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
596154001882	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
596154001883	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
596154001884	Homeodomain-like domain; Region: HTH_23; pfam13384
596154001885	Winged helix-turn helix; Region: HTH_29; pfam13551
596154001886	DDE superfamily endonuclease; Region: DDE_3; pfam13358
596154001887	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
596154001888	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
596154001889	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
596154001890	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
596154001891	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
596154001892	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
596154001893	Walker A/P-loop; other site
596154001894	ATP binding site [chemical binding]; other site
596154001895	Q-loop/lid; other site
596154001896	ABC transporter signature motif; other site
596154001897	Walker B; other site
596154001898	D-loop; other site
596154001899	H-loop/switch region; other site
596154001900	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
596154001901	putative carbohydrate binding site [chemical binding]; other site
596154001902	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
596154001903	putative acyl-acceptor binding pocket; other site
596154001904	Methyltransferase domain; Region: Methyltransf_23; pfam13489
596154001905	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154001906	S-adenosylmethionine binding site [chemical binding]; other site
596154001907	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
596154001908	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
596154001909	N-acetyl-D-glucosamine binding site [chemical binding]; other site
596154001910	catalytic residue [active]
596154001911	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
596154001912	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
596154001913	Mg++ binding site [ion binding]; other site
596154001914	putative catalytic motif [active]
596154001915	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
596154001916	feedback inhibition sensing region; other site
596154001917	homohexameric interface [polypeptide binding]; other site
596154001918	nucleotide binding site [chemical binding]; other site
596154001919	N-acetyl-L-glutamate binding site [chemical binding]; other site
596154001920	division inhibitor protein; Provisional; Region: slmA; PRK09480
596154001921	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154001922	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154001923	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154001924	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
596154001925	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
596154001926	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154001927	active site
596154001928	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
596154001929	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
596154001930	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
596154001931	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
596154001932	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
596154001933	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154001934	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
596154001935	substrate binding site [chemical binding]; other site
596154001936	oxyanion hole (OAH) forming residues; other site
596154001937	trimer interface [polypeptide binding]; other site
596154001938	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
596154001939	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
596154001940	dimer interface [polypeptide binding]; other site
596154001941	active site
596154001942	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
596154001943	enoyl-CoA hydratase; Provisional; Region: PRK06688
596154001944	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154001945	substrate binding site [chemical binding]; other site
596154001946	oxyanion hole (OAH) forming residues; other site
596154001947	trimer interface [polypeptide binding]; other site
596154001948	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
596154001949	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
596154001950	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
596154001951	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
596154001952	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
596154001953	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
596154001954	Walker A/P-loop; other site
596154001955	ATP binding site [chemical binding]; other site
596154001956	Q-loop/lid; other site
596154001957	ABC transporter signature motif; other site
596154001958	Walker B; other site
596154001959	D-loop; other site
596154001960	H-loop/switch region; other site
596154001961	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
596154001962	homodimer interface [polypeptide binding]; other site
596154001963	chemical substrate binding site [chemical binding]; other site
596154001964	oligomer interface [polypeptide binding]; other site
596154001965	metal binding site [ion binding]; metal-binding site
596154001966	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
596154001967	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
596154001968	DctM-like transporters; Region: DctM; pfam06808
596154001969	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
596154001970	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
596154001971	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154001972	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154001973	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
596154001974	dimerization interface [polypeptide binding]; other site
596154001975	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
596154001976	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
596154001977	substrate binding pocket [chemical binding]; other site
596154001978	membrane-bound complex binding site; other site
596154001979	hinge residues; other site
596154001980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154001981	dimer interface [polypeptide binding]; other site
596154001982	conserved gate region; other site
596154001983	putative PBP binding loops; other site
596154001984	ABC-ATPase subunit interface; other site
596154001985	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154001986	dimer interface [polypeptide binding]; other site
596154001987	conserved gate region; other site
596154001988	putative PBP binding loops; other site
596154001989	ABC-ATPase subunit interface; other site
596154001990	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
596154001991	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
596154001992	Walker A/P-loop; other site
596154001993	ATP binding site [chemical binding]; other site
596154001994	Q-loop/lid; other site
596154001995	ABC transporter signature motif; other site
596154001996	Walker B; other site
596154001997	D-loop; other site
596154001998	H-loop/switch region; other site
596154001999	ornithine cyclodeaminase; Validated; Region: PRK07589
596154002000	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
596154002001	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
596154002002	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
596154002003	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
596154002004	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
596154002005	G1 box; other site
596154002006	putative GEF interaction site [polypeptide binding]; other site
596154002007	GTP/Mg2+ binding site [chemical binding]; other site
596154002008	Switch I region; other site
596154002009	G2 box; other site
596154002010	G3 box; other site
596154002011	Switch II region; other site
596154002012	G4 box; other site
596154002013	G5 box; other site
596154002014	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
596154002015	classical (c) SDRs; Region: SDR_c; cd05233
596154002016	short chain dehydrogenase; Provisional; Region: PRK05650
596154002017	NAD(P) binding site [chemical binding]; other site
596154002018	active site
596154002019	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
596154002020	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
596154002021	homotetramer interface [polypeptide binding]; other site
596154002022	ligand binding site [chemical binding]; other site
596154002023	catalytic site [active]
596154002024	NAD binding site [chemical binding]; other site
596154002025	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
596154002026	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
596154002027	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
596154002028	FtsJ-like methyltransferase; Region: FtsJ; cl17430
596154002029	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
596154002030	FAD binding site [chemical binding]; other site
596154002031	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
596154002032	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
596154002033	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
596154002034	Protein kinase domain; Region: Pkinase; pfam00069
596154002035	Catalytic domain of Protein Kinases; Region: PKc; cd00180
596154002036	active site
596154002037	ATP binding site [chemical binding]; other site
596154002038	substrate binding site [chemical binding]; other site
596154002039	activation loop (A-loop); other site
596154002040	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
596154002041	23S rRNA interface [nucleotide binding]; other site
596154002042	L3 interface [polypeptide binding]; other site
596154002043	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
596154002044	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
596154002045	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
596154002046	putative peptidase; Provisional; Region: PRK11649
596154002047	Peptidase family M23; Region: Peptidase_M23; pfam01551
596154002048	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
596154002049	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
596154002050	active site
596154002051	HIGH motif; other site
596154002052	dimer interface [polypeptide binding]; other site
596154002053	KMSKS motif; other site
596154002054	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154002055	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
596154002056	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154002057	dimerization interface [polypeptide binding]; other site
596154002058	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
596154002059	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
596154002060	Substrate binding site; other site
596154002061	Mg++ binding site; other site
596154002062	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
596154002063	active site
596154002064	substrate binding site [chemical binding]; other site
596154002065	CoA binding site [chemical binding]; other site
596154002066	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154002067	dimer interface [polypeptide binding]; other site
596154002068	phosphorylation site [posttranslational modification]
596154002069	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154002070	ATP binding site [chemical binding]; other site
596154002071	G-X-G motif; other site
596154002072	chaperone protein DnaJ; Provisional; Region: PRK14299
596154002073	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
596154002074	HSP70 interaction site [polypeptide binding]; other site
596154002075	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
596154002076	substrate binding site [polypeptide binding]; other site
596154002077	dimer interface [polypeptide binding]; other site
596154002078	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
596154002079	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
596154002080	AsnC family; Region: AsnC_trans_reg; pfam01037
596154002081	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
596154002082	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
596154002083	glutaminase active site [active]
596154002084	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
596154002085	dimer interface [polypeptide binding]; other site
596154002086	active site
596154002087	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
596154002088	dimer interface [polypeptide binding]; other site
596154002089	active site
596154002090	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
596154002091	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154002092	Walker A motif; other site
596154002093	ATP binding site [chemical binding]; other site
596154002094	Walker B motif; other site
596154002095	arginine finger; other site
596154002096	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
596154002097	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154002098	non-specific DNA binding site [nucleotide binding]; other site
596154002099	salt bridge; other site
596154002100	sequence-specific DNA binding site [nucleotide binding]; other site
596154002101	Integrase core domain; Region: rve; pfam00665
596154002102	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
596154002103	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
596154002104	Transposase; Region: HTH_Tnp_1; pfam01527
596154002105	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
596154002106	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
596154002107	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
596154002108	Moco binding site; other site
596154002109	metal coordination site [ion binding]; other site
596154002110	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
596154002111	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
596154002112	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154002113	active site
596154002114	phosphorylation site [posttranslational modification]
596154002115	intermolecular recognition site; other site
596154002116	dimerization interface [polypeptide binding]; other site
596154002117	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
596154002118	DNA binding site [nucleotide binding]
596154002119	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154002120	dimer interface [polypeptide binding]; other site
596154002121	phosphorylation site [posttranslational modification]
596154002122	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154002123	ATP binding site [chemical binding]; other site
596154002124	Mg2+ binding site [ion binding]; other site
596154002125	G-X-G motif; other site
596154002126	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
596154002127	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
596154002128	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
596154002129	Substrate binding site; other site
596154002130	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
596154002131	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
596154002132	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
596154002133	SLBB domain; Region: SLBB; pfam10531
596154002134	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
596154002135	Chain length determinant protein; Region: Wzz; cl15801
596154002136	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
596154002137	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
596154002138	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
596154002139	uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016
596154002140	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
596154002141	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154002142	Walker A motif; other site
596154002143	ATP binding site [chemical binding]; other site
596154002144	Walker B motif; other site
596154002145	arginine finger; other site
596154002146	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
596154002147	polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006
596154002148	putative active site [active]
596154002149	putative catalytic site [active]
596154002150	FemAB-related protein, PEP-CTERM system-associated; Region: pepcterm_femAB; TIGR03019
596154002151	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
596154002152	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
596154002153	exosortase A; Region: exosortase_1; TIGR03109
596154002154	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
596154002155	EpsI family protein; Region: EpsI_fam; TIGR02914
596154002156	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
596154002157	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
596154002158	active site
596154002159	dimer interface [polypeptide binding]; other site
596154002160	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
596154002161	Ligand Binding Site [chemical binding]; other site
596154002162	Molecular Tunnel; other site
596154002163	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
596154002164	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
596154002165	putative ADP-binding pocket [chemical binding]; other site
596154002166	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
596154002167	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
596154002168	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
596154002169	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
596154002170	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
596154002171	O-Antigen ligase; Region: Wzy_C; cl04850
596154002172	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
596154002173	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
596154002174	putative active site [active]
596154002175	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
596154002176	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
596154002177	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
596154002178	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
596154002179	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
596154002180	active site
596154002181	colanic acid exporter; Provisional; Region: PRK10459
596154002182	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
596154002183	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
596154002184	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
596154002185	NAD binding site [chemical binding]; other site
596154002186	substrate binding site [chemical binding]; other site
596154002187	homodimer interface [polypeptide binding]; other site
596154002188	active site
596154002189	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
596154002190	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
596154002191	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
596154002192	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
596154002193	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
596154002194	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
596154002195	exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101
596154002196	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
596154002197	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
596154002198	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
596154002199	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154002200	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154002201	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154002202	acyl-activating enzyme (AAE) consensus motif; other site
596154002203	acyl-activating enzyme (AAE) consensus motif; other site
596154002204	AMP binding site [chemical binding]; other site
596154002205	active site
596154002206	CoA binding site [chemical binding]; other site
596154002207	pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099
596154002208	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
596154002209	dimer interface [polypeptide binding]; other site
596154002210	active site
596154002211	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
596154002212	catalytic residues [active]
596154002213	substrate binding site [chemical binding]; other site
596154002214	GAF domain; Region: GAF_3; pfam13492
596154002215	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
596154002216	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154002217	ATP binding site [chemical binding]; other site
596154002218	Mg2+ binding site [ion binding]; other site
596154002219	G-X-G motif; other site
596154002220	PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915
596154002221	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154002222	active site
596154002223	phosphorylation site [posttranslational modification]
596154002224	intermolecular recognition site; other site
596154002225	dimerization interface [polypeptide binding]; other site
596154002226	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154002227	Walker A motif; other site
596154002228	ATP binding site [chemical binding]; other site
596154002229	Walker B motif; other site
596154002230	arginine finger; other site
596154002231	Helix-turn-helix domain; Region: HTH_17; pfam12728
596154002232	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
596154002233	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
596154002234	binding surface
596154002235	TPR motif; other site
596154002236	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
596154002237	TPR motif; other site
596154002238	binding surface
596154002239	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
596154002240	TPR motif; other site
596154002241	binding surface
596154002242	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
596154002243	TPR motif; other site
596154002244	binding surface
596154002245	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
596154002246	binding surface
596154002247	TPR motif; other site
596154002248	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
596154002249	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
596154002250	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
596154002251	hypothetical protein; Validated; Region: PRK08238
596154002252	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
596154002253	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
596154002254	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
596154002255	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
596154002256	putative dimerization interface [polypeptide binding]; other site
596154002257	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154002258	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
596154002259	rRNA binding site [nucleotide binding]; other site
596154002260	predicted 30S ribosome binding site; other site
596154002261	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
596154002262	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
596154002263	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154002264	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
596154002265	acyl-activating enzyme (AAE) consensus motif; other site
596154002266	acyl-activating enzyme (AAE) consensus motif; other site
596154002267	putative AMP binding site [chemical binding]; other site
596154002268	putative active site [active]
596154002269	putative CoA binding site [chemical binding]; other site
596154002270	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322
596154002271	FAD binding pocket [chemical binding]; other site
596154002272	conserved FAD binding motif [chemical binding]; other site
596154002273	phosphate binding motif [ion binding]; other site
596154002274	beta-alpha-beta structure motif; other site
596154002275	NAD binding pocket [chemical binding]; other site
596154002276	PGAP1-like protein; Region: PGAP1; pfam07819
596154002277	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
596154002278	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
596154002279	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
596154002280	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
596154002281	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
596154002282	catalytic residues [active]
596154002283	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
596154002284	CreA protein; Region: CreA; pfam05981
596154002285	cyanophycin synthetase; Provisional; Region: PRK14016
596154002286	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
596154002287	ATP-grasp domain; Region: ATP-grasp_4; cl17255
596154002288	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
596154002289	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
596154002290	cyanophycin synthetase; Provisional; Region: PRK14016
596154002291	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
596154002292	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
596154002293	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
596154002294	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
596154002295	Walker A/P-loop; other site
596154002296	ATP binding site [chemical binding]; other site
596154002297	Q-loop/lid; other site
596154002298	ABC transporter signature motif; other site
596154002299	Walker B; other site
596154002300	D-loop; other site
596154002301	H-loop/switch region; other site
596154002302	Domain of unknown function (DUF1854); Region: DUF1854; pfam08909
596154002303	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
596154002304	elongation factor G; Reviewed; Region: PRK12740
596154002305	G1 box; other site
596154002306	putative GEF interaction site [polypeptide binding]; other site
596154002307	GTP/Mg2+ binding site [chemical binding]; other site
596154002308	Switch I region; other site
596154002309	G2 box; other site
596154002310	G3 box; other site
596154002311	Switch II region; other site
596154002312	G4 box; other site
596154002313	G5 box; other site
596154002314	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
596154002315	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
596154002316	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
596154002317	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
596154002318	type II secretion system protein F; Region: GspF; TIGR02120
596154002319	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
596154002320	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
596154002321	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
596154002322	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
596154002323	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
596154002324	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
596154002325	type II secretion system protein E; Region: type_II_gspE; TIGR02533
596154002326	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
596154002327	Walker A motif; other site
596154002328	ATP binding site [chemical binding]; other site
596154002329	Walker B motif; other site
596154002330	type II secretion system protein D; Region: type_II_gspD; TIGR02517
596154002331	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
596154002332	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
596154002333	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
596154002334	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
596154002335	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
596154002336	GspL periplasmic domain; Region: GspL_C; cl14909
596154002337	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
596154002338	type II secretion system protein I; Region: gspI; TIGR01707
596154002339	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
596154002340	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
596154002341	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
596154002342	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
596154002343	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
596154002344	cobalamin synthase; Reviewed; Region: cobS; PRK00235
596154002345	threonine dehydratase; Reviewed; Region: PRK09224
596154002346	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
596154002347	tetramer interface [polypeptide binding]; other site
596154002348	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154002349	catalytic residue [active]
596154002350	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
596154002351	putative Ile/Val binding site [chemical binding]; other site
596154002352	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
596154002353	putative Ile/Val binding site [chemical binding]; other site
596154002354	OsmC-like protein; Region: OsmC; cl00767
596154002355	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
596154002356	dinuclear metal binding motif [ion binding]; other site
596154002357	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
596154002358	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
596154002359	trimer interface [polypeptide binding]; other site
596154002360	eyelet of channel; other site
596154002361	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
596154002362	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
596154002363	trimer interface [polypeptide binding]; other site
596154002364	eyelet of channel; other site
596154002365	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
596154002366	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154002367	dimer interface [polypeptide binding]; other site
596154002368	conserved gate region; other site
596154002369	putative PBP binding loops; other site
596154002370	ABC-ATPase subunit interface; other site
596154002371	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
596154002372	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
596154002373	metal binding site [ion binding]; metal-binding site
596154002374	putative dimer interface [polypeptide binding]; other site
596154002375	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
596154002376	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154002377	dimer interface [polypeptide binding]; other site
596154002378	conserved gate region; other site
596154002379	putative PBP binding loops; other site
596154002380	ABC-ATPase subunit interface; other site
596154002381	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
596154002382	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
596154002383	Walker A/P-loop; other site
596154002384	ATP binding site [chemical binding]; other site
596154002385	Q-loop/lid; other site
596154002386	ABC transporter signature motif; other site
596154002387	Walker B; other site
596154002388	D-loop; other site
596154002389	H-loop/switch region; other site
596154002390	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
596154002391	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
596154002392	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
596154002393	Walker A/P-loop; other site
596154002394	ATP binding site [chemical binding]; other site
596154002395	Q-loop/lid; other site
596154002396	ABC transporter signature motif; other site
596154002397	Walker B; other site
596154002398	D-loop; other site
596154002399	H-loop/switch region; other site
596154002400	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
596154002401	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
596154002402	substrate binding site [chemical binding]; other site
596154002403	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
596154002404	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
596154002405	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
596154002406	putative active site [active]
596154002407	transaldolase-like protein; Provisional; Region: PTZ00411
596154002408	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
596154002409	active site
596154002410	dimer interface [polypeptide binding]; other site
596154002411	catalytic residue [active]
596154002412	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
596154002413	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
596154002414	active site
596154002415	dimer interface [polypeptide binding]; other site
596154002416	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
596154002417	dimer interface [polypeptide binding]; other site
596154002418	active site
596154002419	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
596154002420	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
596154002421	ring oligomerisation interface [polypeptide binding]; other site
596154002422	ATP/Mg binding site [chemical binding]; other site
596154002423	stacking interactions; other site
596154002424	hinge regions; other site
596154002425	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
596154002426	oligomerisation interface [polypeptide binding]; other site
596154002427	mobile loop; other site
596154002428	roof hairpin; other site
596154002429	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
596154002430	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
596154002431	active site
596154002432	nucleotide binding site [chemical binding]; other site
596154002433	HIGH motif; other site
596154002434	KMSKS motif; other site
596154002435	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
596154002436	nudix motif; other site
596154002437	S-adenosylmethionine synthetase; Validated; Region: PRK05250
596154002438	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
596154002439	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
596154002440	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
596154002441	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
596154002442	putative acyl-acceptor binding pocket; other site
596154002443	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
596154002444	putative acyl-acceptor binding pocket; other site
596154002445	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154002446	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154002447	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
596154002448	putative dimerization interface [polypeptide binding]; other site
596154002449	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154002450	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154002451	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
596154002452	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
596154002453	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
596154002454	active site
596154002455	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
596154002456	G1 box; other site
596154002457	GTP/Mg2+ binding site [chemical binding]; other site
596154002458	Switch I region; other site
596154002459	G2 box; other site
596154002460	G3 box; other site
596154002461	Switch II region; other site
596154002462	G4 box; other site
596154002463	G5 box; other site
596154002464	Cytochrome c553 [Energy production and conversion]; Region: COG2863
596154002465	Cytochrome c; Region: Cytochrom_C; cl11414
596154002466	ResB-like family; Region: ResB; pfam05140
596154002467	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
596154002468	ResB-like family; Region: ResB; pfam05140
596154002469	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
596154002470	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
596154002471	TMAO/DMSO reductase; Reviewed; Region: PRK05363
596154002472	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
596154002473	Moco binding site; other site
596154002474	metal coordination site [ion binding]; other site
596154002475	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
596154002476	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
596154002477	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
596154002478	diaminopimelate decarboxylase; Region: lysA; TIGR01048
596154002479	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
596154002480	active site
596154002481	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
596154002482	substrate binding site [chemical binding]; other site
596154002483	catalytic residues [active]
596154002484	dimer interface [polypeptide binding]; other site
596154002485	Frataxin-like domain; Region: Frataxin_Cyay; pfam01491
596154002486	putative iron binding site [ion binding]; other site
596154002487	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
596154002488	Transglycosylase; Region: Transgly; pfam00912
596154002489	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
596154002490	Competence protein A; Region: Competence_A; pfam11104
596154002491	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
596154002492	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
596154002493	nucleotide binding site [chemical binding]; other site
596154002494	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
596154002495	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
596154002496	Pilus assembly protein, PilO; Region: PilO; pfam04350
596154002497	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
596154002498	Pilus assembly protein, PilP; Region: PilP; pfam04351
596154002499	AMIN domain; Region: AMIN; pfam11741
596154002500	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
596154002501	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
596154002502	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
596154002503	Putative Ig domain; Region: He_PIG; pfam05345
596154002504	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
596154002505	active site
596154002506	dimer interface [polypeptide binding]; other site
596154002507	metal binding site [ion binding]; metal-binding site
596154002508	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
596154002509	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
596154002510	Zn2+ binding site [ion binding]; other site
596154002511	Mg2+ binding site [ion binding]; other site
596154002512	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
596154002513	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
596154002514	Methyltransferase domain; Region: Methyltransf_31; pfam13847
596154002515	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154002516	S-adenosylmethionine binding site [chemical binding]; other site
596154002517	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
596154002518	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
596154002519	tetrameric interface [polypeptide binding]; other site
596154002520	NAD binding site [chemical binding]; other site
596154002521	catalytic residues [active]
596154002522	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154002523	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
596154002524	putative ligand binding site [chemical binding]; other site
596154002525	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
596154002526	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
596154002527	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
596154002528	active site
596154002529	dimer interface [polypeptide binding]; other site
596154002530	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
596154002531	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
596154002532	active site
596154002533	FMN binding site [chemical binding]; other site
596154002534	substrate binding site [chemical binding]; other site
596154002535	3Fe-4S cluster binding site [ion binding]; other site
596154002536	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
596154002537	domain interface; other site
596154002538	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
596154002539	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
596154002540	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
596154002541	substrate binding pocket [chemical binding]; other site
596154002542	membrane-bound complex binding site; other site
596154002543	hinge residues; other site
596154002544	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
596154002545	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154002546	dimer interface [polypeptide binding]; other site
596154002547	conserved gate region; other site
596154002548	putative PBP binding loops; other site
596154002549	ABC-ATPase subunit interface; other site
596154002550	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
596154002551	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
596154002552	Walker A/P-loop; other site
596154002553	ATP binding site [chemical binding]; other site
596154002554	Q-loop/lid; other site
596154002555	ABC transporter signature motif; other site
596154002556	Walker B; other site
596154002557	D-loop; other site
596154002558	H-loop/switch region; other site
596154002559	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
596154002560	spermidine synthase; Provisional; Region: PRK00811
596154002561	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154002562	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675
596154002563	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
596154002564	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
596154002565	Walker A/P-loop; other site
596154002566	ATP binding site [chemical binding]; other site
596154002567	Q-loop/lid; other site
596154002568	ABC transporter signature motif; other site
596154002569	Walker B; other site
596154002570	D-loop; other site
596154002571	H-loop/switch region; other site
596154002572	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
596154002573	Permease; Region: Permease; pfam02405
596154002574	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
596154002575	mce related protein; Region: MCE; pfam02470
596154002576	VacJ like lipoprotein; Region: VacJ; cl01073
596154002577	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
596154002578	STAS domain; Region: STAS_2; pfam13466
596154002579	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154002580	PAS domain; Region: PAS_9; pfam13426
596154002581	putative active site [active]
596154002582	heme pocket [chemical binding]; other site
596154002583	PAS domain; Region: PAS; smart00091
596154002584	PAS fold; Region: PAS_4; pfam08448
596154002585	putative active site [active]
596154002586	heme pocket [chemical binding]; other site
596154002587	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154002588	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154002589	metal binding site [ion binding]; metal-binding site
596154002590	active site
596154002591	I-site; other site
596154002592	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
596154002593	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
596154002594	Walker A/P-loop; other site
596154002595	ATP binding site [chemical binding]; other site
596154002596	Q-loop/lid; other site
596154002597	ABC transporter signature motif; other site
596154002598	Walker B; other site
596154002599	D-loop; other site
596154002600	H-loop/switch region; other site
596154002601	ABC-2 type transporter; Region: ABC2_membrane; cl17235
596154002602	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
596154002603	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
596154002604	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
596154002605	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
596154002606	hinge; other site
596154002607	active site
596154002608	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
596154002609	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
596154002610	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
596154002611	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
596154002612	NAD binding site [chemical binding]; other site
596154002613	dimerization interface [polypeptide binding]; other site
596154002614	product binding site; other site
596154002615	substrate binding site [chemical binding]; other site
596154002616	zinc binding site [ion binding]; other site
596154002617	catalytic residues [active]
596154002618	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
596154002619	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
596154002620	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154002621	homodimer interface [polypeptide binding]; other site
596154002622	catalytic residue [active]
596154002623	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
596154002624	putative active site pocket [active]
596154002625	4-fold oligomerization interface [polypeptide binding]; other site
596154002626	metal binding residues [ion binding]; metal-binding site
596154002627	3-fold/trimer interface [polypeptide binding]; other site
596154002628	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
596154002629	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
596154002630	putative active site [active]
596154002631	oxyanion strand; other site
596154002632	catalytic triad [active]
596154002633	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
596154002634	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
596154002635	catalytic residues [active]
596154002636	Spherulation-specific family 4; Region: Spherulin4; pfam12138
596154002637	Predicted membrane protein [Function unknown]; Region: COG4267
596154002638	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
596154002639	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
596154002640	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
596154002641	GAF domain; Region: GAF_3; pfam13492
596154002642	Tetratricopeptide repeat; Region: TPR_15; pfam13429
596154002643	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
596154002644	C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922
596154002645	putative active site [active]
596154002646	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
596154002647	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
596154002648	NAD binding site [chemical binding]; other site
596154002649	homodimer interface [polypeptide binding]; other site
596154002650	active site
596154002651	substrate binding site [chemical binding]; other site
596154002652	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
596154002653	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
596154002654	substrate binding site [chemical binding]; other site
596154002655	glutamase interaction surface [polypeptide binding]; other site
596154002656	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
596154002657	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
596154002658	metal binding site [ion binding]; metal-binding site
596154002659	Predicted membrane protein [Function unknown]; Region: COG3671
596154002660	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
596154002661	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
596154002662	active site
596154002663	nucleophile elbow; other site
596154002664	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
596154002665	nucleotide binding site/active site [active]
596154002666	HIT family signature motif; other site
596154002667	catalytic residue [active]
596154002668	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
596154002669	sec-independent translocase; Provisional; Region: tatB; PRK01919
596154002670	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
596154002671	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
596154002672	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
596154002673	protein binding site [polypeptide binding]; other site
596154002674	Uncharacterized conserved protein [Function unknown]; Region: COG0327
596154002675	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
596154002676	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
596154002677	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
596154002678	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
596154002679	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
596154002680	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
596154002681	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
596154002682	[2Fe-2S] cluster binding site [ion binding]; other site
596154002683	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
596154002684	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
596154002685	Qi binding site; other site
596154002686	intrachain domain interface; other site
596154002687	interchain domain interface [polypeptide binding]; other site
596154002688	heme bH binding site [chemical binding]; other site
596154002689	heme bL binding site [chemical binding]; other site
596154002690	Qo binding site; other site
596154002691	interchain domain interface [polypeptide binding]; other site
596154002692	intrachain domain interface; other site
596154002693	Qi binding site; other site
596154002694	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
596154002695	Qo binding site; other site
596154002696	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
596154002697	stringent starvation protein A; Provisional; Region: sspA; PRK09481
596154002698	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
596154002699	C-terminal domain interface [polypeptide binding]; other site
596154002700	putative GSH binding site (G-site) [chemical binding]; other site
596154002701	dimer interface [polypeptide binding]; other site
596154002702	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
596154002703	dimer interface [polypeptide binding]; other site
596154002704	N-terminal domain interface [polypeptide binding]; other site
596154002705	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
596154002706	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
596154002707	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
596154002708	SEC-C motif; Region: SEC-C; pfam02810
596154002709	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
596154002710	heterotetramer interface [polypeptide binding]; other site
596154002711	active site pocket [active]
596154002712	cleavage site
596154002713	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
596154002714	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154002715	Walker A motif; other site
596154002716	ATP binding site [chemical binding]; other site
596154002717	Walker B motif; other site
596154002718	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
596154002719	active site
596154002720	8-oxo-dGMP binding site [chemical binding]; other site
596154002721	nudix motif; other site
596154002722	metal binding site [ion binding]; metal-binding site
596154002723	Domain of unknown function (DUF329); Region: DUF329; pfam03884
596154002724	hypothetical protein; Provisional; Region: PRK05287
596154002725	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
596154002726	dephospho-CoA kinase; Region: TIGR00152
596154002727	CoA-binding site [chemical binding]; other site
596154002728	ATP-binding [chemical binding]; other site
596154002729	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
596154002730	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
596154002731	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
596154002732	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
596154002733	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
596154002734	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
596154002735	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
596154002736	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
596154002737	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
596154002738	Walker A motif; other site
596154002739	ATP binding site [chemical binding]; other site
596154002740	Walker B motif; other site
596154002741	integrase; Provisional; Region: int; PHA02601
596154002742	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
596154002743	active site
596154002744	DNA binding site [nucleotide binding]
596154002745	Int/Topo IB signature motif; other site
596154002746	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
596154002747	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154002748	non-specific DNA binding site [nucleotide binding]; other site
596154002749	salt bridge; other site
596154002750	sequence-specific DNA binding site [nucleotide binding]; other site
596154002751	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
596154002752	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
596154002753	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154002754	Walker A motif; other site
596154002755	ATP binding site [chemical binding]; other site
596154002756	Walker B motif; other site
596154002757	arginine finger; other site
596154002758	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
596154002759	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154002760	non-specific DNA binding site [nucleotide binding]; other site
596154002761	salt bridge; other site
596154002762	sequence-specific DNA binding site [nucleotide binding]; other site
596154002763	Integrase core domain; Region: rve; pfam00665
596154002764	WYL domain; Region: WYL; pfam13280
596154002765	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
596154002766	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
596154002767	active site
596154002768	catalytic residues [active]
596154002769	DNA binding site [nucleotide binding]
596154002770	Int/Topo IB signature motif; other site
596154002771	putative transposase OrfB; Reviewed; Region: PHA02517
596154002772	HTH-like domain; Region: HTH_21; pfam13276
596154002773	Integrase core domain; Region: rve; pfam00665
596154002774	Integrase core domain; Region: rve_3; cl15866
596154002775	Transposase; Region: HTH_Tnp_1; cl17663
596154002776	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
596154002777	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
596154002778	substrate binding pocket [chemical binding]; other site
596154002779	chain length determination region; other site
596154002780	substrate-Mg2+ binding site; other site
596154002781	catalytic residues [active]
596154002782	aspartate-rich region 1; other site
596154002783	active site lid residues [active]
596154002784	aspartate-rich region 2; other site
596154002785	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
596154002786	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
596154002787	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
596154002788	GTPase CgtA; Reviewed; Region: obgE; PRK12299
596154002789	GTP1/OBG; Region: GTP1_OBG; pfam01018
596154002790	Obg GTPase; Region: Obg; cd01898
596154002791	G1 box; other site
596154002792	GTP/Mg2+ binding site [chemical binding]; other site
596154002793	Switch I region; other site
596154002794	G2 box; other site
596154002795	G3 box; other site
596154002796	Switch II region; other site
596154002797	G4 box; other site
596154002798	G5 box; other site
596154002799	gamma-glutamyl kinase; Provisional; Region: PRK05429
596154002800	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
596154002801	nucleotide binding site [chemical binding]; other site
596154002802	homotetrameric interface [polypeptide binding]; other site
596154002803	putative phosphate binding site [ion binding]; other site
596154002804	putative allosteric binding site; other site
596154002805	PUA domain; Region: PUA; pfam01472
596154002806	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
596154002807	putative active site [active]
596154002808	Ap4A binding site [chemical binding]; other site
596154002809	nudix motif; other site
596154002810	putative metal binding site [ion binding]; other site
596154002811	prolyl-tRNA synthetase; Provisional; Region: PRK09194
596154002812	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
596154002813	dimer interface [polypeptide binding]; other site
596154002814	motif 1; other site
596154002815	active site
596154002816	motif 2; other site
596154002817	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
596154002818	putative deacylase active site [active]
596154002819	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
596154002820	active site
596154002821	motif 3; other site
596154002822	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
596154002823	anticodon binding site; other site
596154002824	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
596154002825	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
596154002826	N-acetyl-D-glucosamine binding site [chemical binding]; other site
596154002827	catalytic residue [active]
596154002828	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
596154002829	Domain of unknown function DUF21; Region: DUF21; pfam01595
596154002830	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
596154002831	Transporter associated domain; Region: CorC_HlyC; smart01091
596154002832	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154002833	Walker A motif; other site
596154002834	ATP binding site [chemical binding]; other site
596154002835	Walker B motif; other site
596154002836	arginine finger; other site
596154002837	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
596154002838	putative GSH binding site [chemical binding]; other site
596154002839	catalytic residues [active]
596154002840	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
596154002841	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154002842	S-adenosylmethionine binding site [chemical binding]; other site
596154002843	peptide chain release factor 1; Validated; Region: prfA; PRK00591
596154002844	This domain is found in peptide chain release factors; Region: PCRF; smart00937
596154002845	RF-1 domain; Region: RF-1; pfam00472
596154002846	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
596154002847	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
596154002848	tRNA; other site
596154002849	putative tRNA binding site [nucleotide binding]; other site
596154002850	putative NADP binding site [chemical binding]; other site
596154002851	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
596154002852	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
596154002853	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154002854	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154002855	dimerization interface [polypeptide binding]; other site
596154002856	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154002857	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
596154002858	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
596154002859	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
596154002860	Mechanosensitive ion channel; Region: MS_channel; pfam00924
596154002861	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
596154002862	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
596154002863	putative active site [active]
596154002864	catalytic site [active]
596154002865	putative metal binding site [ion binding]; other site
596154002866	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
596154002867	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
596154002868	Walker A/P-loop; other site
596154002869	ATP binding site [chemical binding]; other site
596154002870	Q-loop/lid; other site
596154002871	ABC transporter signature motif; other site
596154002872	Walker B; other site
596154002873	D-loop; other site
596154002874	H-loop/switch region; other site
596154002875	TOBE domain; Region: TOBE_2; pfam08402
596154002876	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
596154002877	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154002878	dimer interface [polypeptide binding]; other site
596154002879	conserved gate region; other site
596154002880	putative PBP binding loops; other site
596154002881	ABC-ATPase subunit interface; other site
596154002882	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
596154002883	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154002884	dimer interface [polypeptide binding]; other site
596154002885	conserved gate region; other site
596154002886	ABC-ATPase subunit interface; other site
596154002887	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
596154002888	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
596154002889	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
596154002890	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
596154002891	ligand binding site [chemical binding]; other site
596154002892	NAD binding site [chemical binding]; other site
596154002893	tetramer interface [polypeptide binding]; other site
596154002894	catalytic site [active]
596154002895	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
596154002896	L-serine binding site [chemical binding]; other site
596154002897	ACT domain interface; other site
596154002898	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
596154002899	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
596154002900	FAD binding domain; Region: FAD_binding_4; pfam01565
596154002901	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
596154002902	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
596154002903	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
596154002904	Cysteine-rich domain; Region: CCG; pfam02754
596154002905	Cysteine-rich domain; Region: CCG; pfam02754
596154002906	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
596154002907	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
596154002908	HIT family signature motif; other site
596154002909	catalytic residue [active]
596154002910	Protein of unknown function (DUF971); Region: DUF971; pfam06155
596154002911	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
596154002912	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154002913	S-adenosylmethionine binding site [chemical binding]; other site
596154002914	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
596154002915	SCP-2 sterol transfer family; Region: SCP2; pfam02036
596154002916	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
596154002917	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
596154002918	Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474
596154002919	Na binding site [ion binding]; other site
596154002920	putative glycosylation site [posttranslational modification]; other site
596154002921	putative glycosylation site [posttranslational modification]; other site
596154002922	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
596154002923	Uncharacterized conserved protein [Function unknown]; Region: COG2928
596154002924	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
596154002925	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
596154002926	dimer interface [polypeptide binding]; other site
596154002927	anticodon binding site; other site
596154002928	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
596154002929	homodimer interface [polypeptide binding]; other site
596154002930	motif 1; other site
596154002931	active site
596154002932	motif 2; other site
596154002933	GAD domain; Region: GAD; pfam02938
596154002934	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
596154002935	motif 3; other site
596154002936	dihydroneopterin triphosphate pyrophosphatase; Provisional; Region: nudB; PRK09438
596154002937	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
596154002938	putative catalytic site [active]
596154002939	putative metal binding site [ion binding]; other site
596154002940	putative phosphate binding site [ion binding]; other site
596154002941	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
596154002942	putative active site [active]
596154002943	catalytic site [active]
596154002944	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
596154002945	putative active site [active]
596154002946	catalytic site [active]
596154002947	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
596154002948	active site
596154002949	Sensors of blue-light using FAD; Region: BLUF; smart01034
596154002950	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
596154002951	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
596154002952	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154002953	dimer interface [polypeptide binding]; other site
596154002954	phosphorylation site [posttranslational modification]
596154002955	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154002956	ATP binding site [chemical binding]; other site
596154002957	G-X-G motif; other site
596154002958	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
596154002959	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154002960	active site
596154002961	phosphorylation site [posttranslational modification]
596154002962	intermolecular recognition site; other site
596154002963	dimerization interface [polypeptide binding]; other site
596154002964	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
596154002965	DNA binding residues [nucleotide binding]
596154002966	Cytochrome c [Energy production and conversion]; Region: COG3258
596154002967	Cytochrome c; Region: Cytochrom_C; pfam00034
596154002968	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
596154002969	amidase; Provisional; Region: PRK07042
596154002970	Amidase; Region: Amidase; cl11426
596154002971	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
596154002972	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
596154002973	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
596154002974	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
596154002975	Walker A/P-loop; other site
596154002976	ATP binding site [chemical binding]; other site
596154002977	Q-loop/lid; other site
596154002978	ABC transporter signature motif; other site
596154002979	Walker B; other site
596154002980	D-loop; other site
596154002981	H-loop/switch region; other site
596154002982	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
596154002983	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
596154002984	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
596154002985	Walker A/P-loop; other site
596154002986	ATP binding site [chemical binding]; other site
596154002987	Q-loop/lid; other site
596154002988	ABC transporter signature motif; other site
596154002989	Walker B; other site
596154002990	D-loop; other site
596154002991	H-loop/switch region; other site
596154002992	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
596154002993	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
596154002994	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154002995	dimer interface [polypeptide binding]; other site
596154002996	conserved gate region; other site
596154002997	putative PBP binding loops; other site
596154002998	ABC-ATPase subunit interface; other site
596154002999	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
596154003000	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154003001	dimer interface [polypeptide binding]; other site
596154003002	conserved gate region; other site
596154003003	putative PBP binding loops; other site
596154003004	ABC-ATPase subunit interface; other site
596154003005	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
596154003006	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
596154003007	putative active site [active]
596154003008	catalytic residue [active]
596154003009	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
596154003010	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
596154003011	5S rRNA interface [nucleotide binding]; other site
596154003012	CTC domain interface [polypeptide binding]; other site
596154003013	L16 interface [polypeptide binding]; other site
596154003014	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
596154003015	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
596154003016	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
596154003017	active site
596154003018	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
596154003019	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
596154003020	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
596154003021	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
596154003022	binding surface
596154003023	TPR motif; other site
596154003024	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
596154003025	binding surface
596154003026	TPR motif; other site
596154003027	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
596154003028	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
596154003029	DNA binding site [nucleotide binding]
596154003030	catalytic residue [active]
596154003031	H2TH interface [polypeptide binding]; other site
596154003032	putative catalytic residues [active]
596154003033	turnover-facilitating residue; other site
596154003034	intercalation triad [nucleotide binding]; other site
596154003035	8OG recognition residue [nucleotide binding]; other site
596154003036	putative reading head residues; other site
596154003037	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
596154003038	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
596154003039	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
596154003040	Dynamin family; Region: Dynamin_N; pfam00350
596154003041	G1 box; other site
596154003042	GTP/Mg2+ binding site [chemical binding]; other site
596154003043	G2 box; other site
596154003044	Switch I region; other site
596154003045	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
596154003046	G3 box; other site
596154003047	Switch II region; other site
596154003048	GTP/Mg2+ binding site [chemical binding]; other site
596154003049	G4 box; other site
596154003050	G5 box; other site
596154003051	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
596154003052	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
596154003053	minor groove reading motif; other site
596154003054	helix-hairpin-helix signature motif; other site
596154003055	substrate binding pocket [chemical binding]; other site
596154003056	active site
596154003057	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
596154003058	DNA binding and oxoG recognition site [nucleotide binding]
596154003059	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
596154003060	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
596154003061	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
596154003062	Walker A/P-loop; other site
596154003063	ATP binding site [chemical binding]; other site
596154003064	Q-loop/lid; other site
596154003065	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
596154003066	ABC transporter signature motif; other site
596154003067	Walker B; other site
596154003068	D-loop; other site
596154003069	H-loop/switch region; other site
596154003070	NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155
596154003071	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
596154003072	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
596154003073	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
596154003074	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
596154003075	putative transposase OrfB; Reviewed; Region: PHA02517
596154003076	HTH-like domain; Region: HTH_21; pfam13276
596154003077	Integrase core domain; Region: rve; pfam00665
596154003078	Integrase core domain; Region: rve_3; cl15866
596154003079	Transposase; Region: HTH_Tnp_1; cl17663
596154003080	Protein of unknown function (DUF3240); Region: DUF3240; pfam11582
596154003081	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
596154003082	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
596154003083	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
596154003084	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
596154003085	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
596154003086	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
596154003087	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154003088	dimer interface [polypeptide binding]; other site
596154003089	phosphorylation site [posttranslational modification]
596154003090	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154003091	Mg2+ binding site [ion binding]; other site
596154003092	G-X-G motif; other site
596154003093	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
596154003094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154003095	active site
596154003096	phosphorylation site [posttranslational modification]
596154003097	intermolecular recognition site; other site
596154003098	dimerization interface [polypeptide binding]; other site
596154003099	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
596154003100	DNA binding site [nucleotide binding]
596154003101	6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240
596154003102	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
596154003103	putative NAD(P) binding site [chemical binding]; other site
596154003104	catalytic Zn binding site [ion binding]; other site
596154003105	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
596154003106	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
596154003107	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
596154003108	substrate binding pocket [chemical binding]; other site
596154003109	membrane-bound complex binding site; other site
596154003110	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154003111	DNA-binding site [nucleotide binding]; DNA binding site
596154003112	Transcriptional regulators [Transcription]; Region: GntR; COG1802
596154003113	FCD domain; Region: FCD; pfam07729
596154003114	aconitate hydratase; Provisional; Region: acnA; PRK12881
596154003115	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
596154003116	substrate binding site [chemical binding]; other site
596154003117	ligand binding site [chemical binding]; other site
596154003118	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
596154003119	substrate binding site [chemical binding]; other site
596154003120	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154003121	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154003122	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
596154003123	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326
596154003124	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
596154003125	putative active site pocket [active]
596154003126	metal binding site [ion binding]; metal-binding site
596154003127	short chain dehydrogenase; Provisional; Region: PRK07577
596154003128	classical (c) SDRs; Region: SDR_c; cd05233
596154003129	NAD(P) binding site [chemical binding]; other site
596154003130	active site
596154003131	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154003132	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
596154003133	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
596154003134	inhibitor site; inhibition site
596154003135	active site
596154003136	dimer interface [polypeptide binding]; other site
596154003137	catalytic residue [active]
596154003138	cell density-dependent motility repressor; Provisional; Region: PRK10082
596154003139	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154003140	LysR substrate binding domain; Region: LysR_substrate; pfam03466
596154003141	dimerization interface [polypeptide binding]; other site
596154003142	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
596154003143	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
596154003144	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
596154003145	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
596154003146	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
596154003147	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
596154003148	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
596154003149	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
596154003150	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154003151	S-adenosylmethionine binding site [chemical binding]; other site
596154003152	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
596154003153	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
596154003154	active site
596154003155	(T/H)XGH motif; other site
596154003156	BON domain; Region: BON; pfam04972
596154003157	CHASE3 domain; Region: CHASE3; pfam05227
596154003158	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
596154003159	Histidine kinase; Region: HisKA_3; pfam07730
596154003160	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154003161	ATP binding site [chemical binding]; other site
596154003162	Mg2+ binding site [ion binding]; other site
596154003163	G-X-G motif; other site
596154003164	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
596154003165	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154003166	active site
596154003167	phosphorylation site [posttranslational modification]
596154003168	intermolecular recognition site; other site
596154003169	dimerization interface [polypeptide binding]; other site
596154003170	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
596154003171	DNA binding residues [nucleotide binding]
596154003172	dimerization interface [polypeptide binding]; other site
596154003173	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154003174	Response regulator receiver domain; Region: Response_reg; pfam00072
596154003175	active site
596154003176	phosphorylation site [posttranslational modification]
596154003177	intermolecular recognition site; other site
596154003178	dimerization interface [polypeptide binding]; other site
596154003179	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
596154003180	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
596154003181	ATP binding site [chemical binding]; other site
596154003182	substrate interface [chemical binding]; other site
596154003183	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
596154003184	C-terminal peptidase (prc); Region: prc; TIGR00225
596154003185	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
596154003186	protein binding site [polypeptide binding]; other site
596154003187	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
596154003188	Catalytic dyad [active]
596154003189	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
596154003190	catalytic core [active]
596154003191	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
596154003192	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
596154003193	active site residue [active]
596154003194	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
596154003195	GSH binding site [chemical binding]; other site
596154003196	catalytic residues [active]
596154003197	preprotein translocase subunit SecB; Validated; Region: PRK05751
596154003198	SecA binding site; other site
596154003199	Preprotein binding site; other site
596154003200	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
596154003201	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
596154003202	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
596154003203	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154003204	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
596154003205	Uncharacterized conserved protein [Function unknown]; Region: COG5476
596154003206	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
596154003207	MlrC C-terminus; Region: MlrC_C; pfam07171
596154003208	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154003209	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154003210	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154003211	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
596154003212	dimerization interface [polypeptide binding]; other site
596154003213	pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380
596154003214	pantoate--beta-alanine ligase; Region: panC; TIGR00018
596154003215	active site
596154003216	nucleotide binding site [chemical binding]; other site
596154003217	HIGH motif; other site
596154003218	KMSKS motif; other site
596154003219	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
596154003220	oligomerization interface [polypeptide binding]; other site
596154003221	active site
596154003222	metal binding site [ion binding]; metal-binding site
596154003223	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978
596154003224	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
596154003225	dimerization interface [polypeptide binding]; other site
596154003226	active site
596154003227	quinolinate synthetase; Provisional; Region: PRK09375
596154003228	chorismate binding enzyme; Region: Chorismate_bind; cl10555
596154003229	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
596154003230	substrate-cofactor binding pocket; other site
596154003231	homodimer interface [polypeptide binding]; other site
596154003232	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
596154003233	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154003234	catalytic residue [active]
596154003235	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
596154003236	putative substrate binding pocket [chemical binding]; other site
596154003237	trimer interface [polypeptide binding]; other site
596154003238	L-aspartate oxidase; Provisional; Region: PRK09077
596154003239	L-aspartate oxidase; Provisional; Region: PRK06175
596154003240	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
596154003241	Cupin; Region: Cupin_6; pfam12852
596154003242	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
596154003243	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
596154003244	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
596154003245	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
596154003246	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
596154003247	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
596154003248	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
596154003249	hypothetical protein; Validated; Region: PRK07586
596154003250	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
596154003251	PYR/PP interface [polypeptide binding]; other site
596154003252	dimer interface [polypeptide binding]; other site
596154003253	TPP binding site [chemical binding]; other site
596154003254	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
596154003255	TPP-binding site [chemical binding]; other site
596154003256	dimer interface [polypeptide binding]; other site
596154003257	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
596154003258	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
596154003259	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
596154003260	phosphate binding site [ion binding]; other site
596154003261	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
596154003262	FAD binding domain; Region: FAD_binding_2; pfam00890
596154003263	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
596154003264	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
596154003265	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
596154003266	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
596154003267	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
596154003268	catalytic triad [active]
596154003269	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
596154003270	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
596154003271	catalytic residue [active]
596154003272	benzoate transporter; Region: benE; TIGR00843
596154003273	Benzoate membrane transport protein; Region: BenE; pfam03594
596154003274	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
596154003275	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154003276	DNA-binding site [nucleotide binding]; DNA binding site
596154003277	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
596154003278	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154003279	homodimer interface [polypeptide binding]; other site
596154003280	catalytic residue [active]
596154003281	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
596154003282	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
596154003283	active site
596154003284	HIGH motif; other site
596154003285	KMSKS motif; other site
596154003286	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
596154003287	tRNA binding surface [nucleotide binding]; other site
596154003288	anticodon binding site; other site
596154003289	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
596154003290	dimer interface [polypeptide binding]; other site
596154003291	putative tRNA-binding site [nucleotide binding]; other site
596154003292	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
596154003293	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
596154003294	active site
596154003295	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
596154003296	Restriction endonuclease; Region: Mrr_cat; pfam04471
596154003297	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
596154003298	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
596154003299	active site residue [active]
596154003300	selenophosphate synthetase; Provisional; Region: PRK00943
596154003301	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
596154003302	dimerization interface [polypeptide binding]; other site
596154003303	putative ATP binding site [chemical binding]; other site
596154003304	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
596154003305	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
596154003306	gating phenylalanine in ion channel; other site
596154003307	Domain of unknown function DUF59; Region: DUF59; pfam01883
596154003308	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
596154003309	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
596154003310	Walker A motif; other site
596154003311	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
596154003312	putative active site [active]
596154003313	putative catalytic site [active]
596154003314	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154003315	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
596154003316	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154003317	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154003318	active site
596154003319	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154003320	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154003321	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
596154003322	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154003323	DNA-binding site [nucleotide binding]; DNA binding site
596154003324	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
596154003325	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154003326	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
596154003327	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
596154003328	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082
596154003329	putative dimer interface [polypeptide binding]; other site
596154003330	[2Fe-2S] cluster binding site [ion binding]; other site
596154003331	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
596154003332	SLBB domain; Region: SLBB; pfam10531
596154003333	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
596154003334	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
596154003335	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
596154003336	catalytic loop [active]
596154003337	iron binding site [ion binding]; other site
596154003338	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
596154003339	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
596154003340	[4Fe-4S] binding site [ion binding]; other site
596154003341	molybdopterin cofactor binding site; other site
596154003342	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
596154003343	molybdopterin cofactor binding site; other site
596154003344	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
596154003345	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
596154003346	4Fe-4S binding domain; Region: Fer4; pfam00037
596154003347	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
596154003348	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
596154003349	4Fe-4S binding domain; Region: Fer4; pfam00037
596154003350	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
596154003351	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
596154003352	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
596154003353	formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811
596154003354	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
596154003355	[4Fe-4S] binding site [ion binding]; other site
596154003356	molybdopterin cofactor binding site; other site
596154003357	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
596154003358	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
596154003359	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
596154003360	molybdopterin cofactor binding site; other site
596154003361	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
596154003362	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
596154003363	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
596154003364	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
596154003365	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
596154003366	FtsX-like permease family; Region: FtsX; pfam02687
596154003367	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
596154003368	AAA domain; Region: AAA_33; pfam13671
596154003369	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
596154003370	active site
596154003371	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
596154003372	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
596154003373	apolar tunnel; other site
596154003374	heme binding site [chemical binding]; other site
596154003375	dimerization interface [polypeptide binding]; other site
596154003376	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
596154003377	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154003378	DNA-binding site [nucleotide binding]; DNA binding site
596154003379	UTRA domain; Region: UTRA; pfam07702
596154003380	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
596154003381	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
596154003382	tetramer interface [polypeptide binding]; other site
596154003383	active site
596154003384	Mg2+/Mn2+ binding site [ion binding]; other site
596154003385	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
596154003386	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
596154003387	hypothetical protein; Provisional; Region: PRK14812
596154003388	substrate binding site [chemical binding]; other site
596154003389	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
596154003390	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
596154003391	substrate binding site [chemical binding]; other site
596154003392	ligand binding site [chemical binding]; other site
596154003393	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154003394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
596154003395	Smr domain; Region: Smr; pfam01713
596154003396	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
596154003397	hypothetical protein; Reviewed; Region: PRK00024
596154003398	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
596154003399	MPN+ (JAMM) motif; other site
596154003400	Zinc-binding site [ion binding]; other site
596154003401	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
596154003402	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
596154003403	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
596154003404	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
596154003405	Domain of unknown function DUF21; Region: DUF21; pfam01595
596154003406	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
596154003407	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
596154003408	Transporter associated domain; Region: CorC_HlyC; smart01091
596154003409	FOG: CBS domain [General function prediction only]; Region: COG0517
596154003410	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
596154003411	seryl-tRNA synthetase; Provisional; Region: PRK05431
596154003412	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
596154003413	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
596154003414	dimer interface [polypeptide binding]; other site
596154003415	active site
596154003416	motif 1; other site
596154003417	motif 2; other site
596154003418	motif 3; other site
596154003419	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
596154003420	integrase; Provisional; Region: PRK09692
596154003421	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
596154003422	active site
596154003423	Int/Topo IB signature motif; other site
596154003424	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
596154003425	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154003426	sequence-specific DNA binding site [nucleotide binding]; other site
596154003427	salt bridge; other site
596154003428	AAA domain; Region: AAA_25; pfam13481
596154003429	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154003430	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
596154003431	Walker A motif; other site
596154003432	Walker A/P-loop; other site
596154003433	ATP binding site [chemical binding]; other site
596154003434	Walker B motif; other site
596154003435	This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901
596154003436	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
596154003437	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
596154003438	Bacterial sugar transferase; Region: Bac_transf; pfam02397
596154003439	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
596154003440	CHASE2 domain; Region: CHASE2; pfam05226
596154003441	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
596154003442	dimer interface [polypeptide binding]; other site
596154003443	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
596154003444	phosphorylation site [posttranslational modification]
596154003445	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154003446	ATP binding site [chemical binding]; other site
596154003447	Mg2+ binding site [ion binding]; other site
596154003448	G-X-G motif; other site
596154003449	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
596154003450	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
596154003451	FecR protein; Region: FecR; pfam04773
596154003452	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
596154003453	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154003454	active site
596154003455	phosphorylation site [posttranslational modification]
596154003456	intermolecular recognition site; other site
596154003457	dimerization interface [polypeptide binding]; other site
596154003458	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
596154003459	DNA binding site [nucleotide binding]
596154003460	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284
596154003461	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
596154003462	active site
596154003463	HIGH motif; other site
596154003464	dimer interface [polypeptide binding]; other site
596154003465	KMSKS motif; other site
596154003466	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
596154003467	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
596154003468	Peptidase family M50; Region: Peptidase_M50; pfam02163
596154003469	active site
596154003470	putative substrate binding region [chemical binding]; other site
596154003471	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
596154003472	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
596154003473	dimer interface [polypeptide binding]; other site
596154003474	putative CheW interface [polypeptide binding]; other site
596154003475	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
596154003476	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
596154003477	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
596154003478	active site
596154003479	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
596154003480	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
596154003481	dimerization interface [polypeptide binding]; other site
596154003482	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
596154003483	dimer interface [polypeptide binding]; other site
596154003484	putative CheW interface [polypeptide binding]; other site
596154003485	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
596154003486	DHH family; Region: DHH; pfam01368
596154003487	DHHA1 domain; Region: DHHA1; pfam02272
596154003488	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
596154003489	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
596154003490	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
596154003491	FtsX-like permease family; Region: FtsX; pfam02687
596154003492	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
596154003493	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
596154003494	Walker A/P-loop; other site
596154003495	ATP binding site [chemical binding]; other site
596154003496	Q-loop/lid; other site
596154003497	ABC transporter signature motif; other site
596154003498	Walker B; other site
596154003499	D-loop; other site
596154003500	H-loop/switch region; other site
596154003501	Cytochrome c; Region: Cytochrom_C; cl11414
596154003502	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
596154003503	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
596154003504	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
596154003505	CoenzymeA binding site [chemical binding]; other site
596154003506	subunit interaction site [polypeptide binding]; other site
596154003507	PHB binding site; other site
596154003508	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
596154003509	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
596154003510	heme binding site [chemical binding]; other site
596154003511	ferroxidase pore; other site
596154003512	ferroxidase diiron center [ion binding]; other site
596154003513	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
596154003514	Transcriptional regulators [Transcription]; Region: GntR; COG1802
596154003515	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154003516	DNA-binding site [nucleotide binding]; DNA binding site
596154003517	FCD domain; Region: FCD; pfam07729
596154003518	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
596154003519	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154003520	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154003521	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
596154003522	substrate binding site [chemical binding]; other site
596154003523	oxyanion hole (OAH) forming residues; other site
596154003524	trimer interface [polypeptide binding]; other site
596154003525	malonyl-CoA synthase; Validated; Region: PRK07514
596154003526	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
596154003527	acyl-activating enzyme (AAE) consensus motif; other site
596154003528	active site
596154003529	AMP binding site [chemical binding]; other site
596154003530	CoA binding site [chemical binding]; other site
596154003531	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
596154003532	Ligand Binding Site [chemical binding]; other site
596154003533	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
596154003534	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
596154003535	metal-binding site [ion binding]
596154003536	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
596154003537	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
596154003538	Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197
596154003539	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
596154003540	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
596154003541	Low-spin heme binding site [chemical binding]; other site
596154003542	Putative water exit pathway; other site
596154003543	Binuclear center (active site) [active]
596154003544	Putative proton exit pathway; other site
596154003545	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
596154003546	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
596154003547	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
596154003548	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
596154003549	Cytochrome c; Region: Cytochrom_C; pfam00034
596154003550	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
596154003551	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
596154003552	4Fe-4S binding domain; Region: Fer4_5; pfam12801
596154003553	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
596154003554	FixH; Region: FixH; pfam05751
596154003555	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
596154003556	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
596154003557	ligand binding site [chemical binding]; other site
596154003558	flexible hinge region; other site
596154003559	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
596154003560	putative switch regulator; other site
596154003561	non-specific DNA interactions [nucleotide binding]; other site
596154003562	DNA binding site [nucleotide binding]
596154003563	sequence specific DNA binding site [nucleotide binding]; other site
596154003564	putative cAMP binding site [chemical binding]; other site
596154003565	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
596154003566	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
596154003567	FeS/SAM binding site; other site
596154003568	HemN C-terminal domain; Region: HemN_C; pfam06969
596154003569	Family description; Region: DsbD_2; pfam13386
596154003570	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
596154003571	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
596154003572	Zn2+ binding site [ion binding]; other site
596154003573	Mg2+ binding site [ion binding]; other site
596154003574	PAS domain; Region: PAS; smart00091
596154003575	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
596154003576	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154003577	PAS domain; Region: PAS_9; pfam13426
596154003578	putative active site [active]
596154003579	heme pocket [chemical binding]; other site
596154003580	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154003581	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154003582	metal binding site [ion binding]; metal-binding site
596154003583	active site
596154003584	I-site; other site
596154003585	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
596154003586	Cell division protein ZapA; Region: ZapA; pfam05164
596154003587	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
596154003588	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
596154003589	N-terminal plug; other site
596154003590	ligand-binding site [chemical binding]; other site
596154003591	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
596154003592	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
596154003593	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
596154003594	catalytic triad [active]
596154003595	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
596154003596	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
596154003597	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
596154003598	intersubunit interface [polypeptide binding]; other site
596154003599	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
596154003600	dimer interface [polypeptide binding]; other site
596154003601	putative PBP binding regions; other site
596154003602	ABC-ATPase subunit  interface; other site
596154003603	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
596154003604	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
596154003605	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
596154003606	Walker A/P-loop; other site
596154003607	ATP binding site [chemical binding]; other site
596154003608	Q-loop/lid; other site
596154003609	ABC transporter signature motif; other site
596154003610	Walker B; other site
596154003611	D-loop; other site
596154003612	H-loop/switch region; other site
596154003613	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
596154003614	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
596154003615	homodimer interface [polypeptide binding]; other site
596154003616	Walker A motif; other site
596154003617	ATP binding site [chemical binding]; other site
596154003618	hydroxycobalamin binding site [chemical binding]; other site
596154003619	Walker B motif; other site
596154003620	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
596154003621	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
596154003622	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
596154003623	DNA binding site [nucleotide binding]
596154003624	active site
596154003625	Methyltransferase domain; Region: Methyltransf_31; pfam13847
596154003626	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154003627	S-adenosylmethionine binding site [chemical binding]; other site
596154003628	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
596154003629	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
596154003630	active site
596154003631	FMN binding site [chemical binding]; other site
596154003632	substrate binding site [chemical binding]; other site
596154003633	homotetramer interface [polypeptide binding]; other site
596154003634	catalytic residue [active]
596154003635	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154003636	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154003637	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154003638	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
596154003639	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154003640	NAD(P) binding site [chemical binding]; other site
596154003641	active site
596154003642	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
596154003643	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154003644	NAD(P) binding site [chemical binding]; other site
596154003645	active site
596154003646	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154003647	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154003648	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
596154003649	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154003650	NAD(P) binding site [chemical binding]; other site
596154003651	active site
596154003652	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154003653	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
596154003654	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
596154003655	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154003656	substrate binding site [chemical binding]; other site
596154003657	oxyanion hole (OAH) forming residues; other site
596154003658	trimer interface [polypeptide binding]; other site
596154003659	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
596154003660	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154003661	active site
596154003662	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154003663	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154003664	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
596154003665	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154003666	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154003667	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154003668	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
596154003669	substrate binding site [chemical binding]; other site
596154003670	oxyanion hole (OAH) forming residues; other site
596154003671	trimer interface [polypeptide binding]; other site
596154003672	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
596154003673	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
596154003674	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
596154003675	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
596154003676	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154003677	substrate binding site [chemical binding]; other site
596154003678	oxyanion hole (OAH) forming residues; other site
596154003679	trimer interface [polypeptide binding]; other site
596154003680	thiolase; Provisional; Region: PRK06158
596154003681	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
596154003682	active site
596154003683	DUF35 OB-fold domain; Region: DUF35; pfam01796
596154003684	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
596154003685	CoA binding domain; Region: CoA_binding_2; pfam13380
596154003686	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
596154003687	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
596154003688	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154003689	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154003690	active site
596154003691	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
596154003692	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154003693	substrate binding site [chemical binding]; other site
596154003694	oxyanion hole (OAH) forming residues; other site
596154003695	trimer interface [polypeptide binding]; other site
596154003696	thiolase; Provisional; Region: PRK06158
596154003697	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
596154003698	active site
596154003699	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
596154003700	DUF35 OB-fold domain; Region: DUF35; pfam01796
596154003701	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
596154003702	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
596154003703	dimer interface [polypeptide binding]; other site
596154003704	active site
596154003705	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
596154003706	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154003707	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
596154003708	Ligand binding site [chemical binding]; other site
596154003709	Electron transfer flavoprotein domain; Region: ETF; pfam01012
596154003710	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
596154003711	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
596154003712	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
596154003713	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
596154003714	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
596154003715	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
596154003716	active site
596154003717	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
596154003718	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
596154003719	FAD binding site [chemical binding]; other site
596154003720	substrate binding site [chemical binding]; other site
596154003721	catalytic base [active]
596154003722	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154003723	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
596154003724	aminotransferase AlaT; Validated; Region: PRK09265
596154003725	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
596154003726	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154003727	homodimer interface [polypeptide binding]; other site
596154003728	catalytic residue [active]
596154003729	homoserine dehydrogenase; Provisional; Region: PRK06349
596154003730	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
596154003731	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
596154003732	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
596154003733	prevent-host-death family protein; Region: phd_fam; TIGR01552
596154003734	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
596154003735	oligomeric interface; other site
596154003736	putative active site [active]
596154003737	homodimer interface [polypeptide binding]; other site
596154003738	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
596154003739	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
596154003740	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154003741	catalytic residue [active]
596154003742	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
596154003743	Walker A motif; other site
596154003744	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
596154003745	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
596154003746	dimer interface [polypeptide binding]; other site
596154003747	putative functional site; other site
596154003748	putative MPT binding site; other site
596154003749	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
596154003750	MoaE interaction surface [polypeptide binding]; other site
596154003751	MoeB interaction surface [polypeptide binding]; other site
596154003752	thiocarboxylated glycine; other site
596154003753	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
596154003754	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
596154003755	dimer interface [polypeptide binding]; other site
596154003756	active site
596154003757	catalytic residue [active]
596154003758	Protein of unknown function (DUF3149); Region: DUF3149; pfam11346
596154003759	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
596154003760	MoaE homodimer interface [polypeptide binding]; other site
596154003761	MoaD interaction [polypeptide binding]; other site
596154003762	active site residues [active]
596154003763	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
596154003764	Clp amino terminal domain; Region: Clp_N; pfam02861
596154003765	Clp amino terminal domain; Region: Clp_N; pfam02861
596154003766	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154003767	Walker A motif; other site
596154003768	ATP binding site [chemical binding]; other site
596154003769	Walker B motif; other site
596154003770	arginine finger; other site
596154003771	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154003772	Walker A motif; other site
596154003773	ATP binding site [chemical binding]; other site
596154003774	Walker B motif; other site
596154003775	arginine finger; other site
596154003776	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
596154003777	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
596154003778	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
596154003779	NAD(P) binding site [chemical binding]; other site
596154003780	catalytic residues [active]
596154003781	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
596154003782	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
596154003783	Coenzyme A binding pocket [chemical binding]; other site
596154003784	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
596154003785	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154003786	S-adenosylmethionine binding site [chemical binding]; other site
596154003787	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
596154003788	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
596154003789	FMN binding site [chemical binding]; other site
596154003790	active site
596154003791	catalytic residues [active]
596154003792	substrate binding site [chemical binding]; other site
596154003793	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
596154003794	putative active site [active]
596154003795	catalytic site [active]
596154003796	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
596154003797	PLD-like domain; Region: PLDc_2; pfam13091
596154003798	putative active site [active]
596154003799	catalytic site [active]
596154003800	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
596154003801	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
596154003802	catalytic motif [active]
596154003803	Zn binding site [ion binding]; other site
596154003804	RibD C-terminal domain; Region: RibD_C; cl17279
596154003805	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
596154003806	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
596154003807	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
596154003808	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
596154003809	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
596154003810	PilX N-terminal; Region: PilX_N; pfam14341
596154003811	Type IV pilus assembly protein PilX C-term; Region: PilX; pfam13681
596154003812	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
596154003813	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
596154003814	Type II transport protein GspH; Region: GspH; pfam12019
596154003815	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
596154003816	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
596154003817	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
596154003818	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
596154003819	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
596154003820	catalytic residue [active]
596154003821	cobyric acid synthase; Provisional; Region: PRK00784
596154003822	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
596154003823	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
596154003824	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
596154003825	catalytic triad [active]
596154003826	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
596154003827	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
596154003828	active site pocket [active]
596154003829	putative dimer interface [polypeptide binding]; other site
596154003830	putative cataytic base [active]
596154003831	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
596154003832	ADP-ribose binding site [chemical binding]; other site
596154003833	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
596154003834	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
596154003835	minor groove reading motif; other site
596154003836	helix-hairpin-helix signature motif; other site
596154003837	substrate binding pocket [chemical binding]; other site
596154003838	active site
596154003839	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
596154003840	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154003841	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154003842	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154003843	dimerization interface [polypeptide binding]; other site
596154003844	amidase; Provisional; Region: PRK07486
596154003845	Amidase; Region: Amidase; cl11426
596154003846	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154003847	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
596154003848	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
596154003849	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
596154003850	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154003851	homodimer interface [polypeptide binding]; other site
596154003852	catalytic residue [active]
596154003853	SlyX; Region: SlyX; pfam04102
596154003854	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
596154003855	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
596154003856	active site
596154003857	catalytic tetrad [active]
596154003858	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
596154003859	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
596154003860	heme-binding site [chemical binding]; other site
596154003861	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
596154003862	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
596154003863	Hemerythrin-like domain; Region: Hr-like; cd12108
596154003864	Fe binding site [ion binding]; other site
596154003865	Transcriptional regulator; Region: Rrf2; cl17282
596154003866	Rrf2 family protein; Region: rrf2_super; TIGR00738
596154003867	PrkA family serine protein kinase; Provisional; Region: PRK15455
596154003868	AAA ATPase domain; Region: AAA_16; pfam13191
596154003869	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
596154003870	hypothetical protein; Provisional; Region: PRK05325
596154003871	SpoVR family protein; Provisional; Region: PRK11767
596154003872	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
596154003873	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
596154003874	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
596154003875	Histidine kinase; Region: His_kinase; pfam06580
596154003876	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
596154003877	ATP binding site [chemical binding]; other site
596154003878	Mg2+ binding site [ion binding]; other site
596154003879	G-X-G motif; other site
596154003880	argininosuccinate lyase; Provisional; Region: PRK00855
596154003881	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
596154003882	active sites [active]
596154003883	tetramer interface [polypeptide binding]; other site
596154003884	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154003885	Bacterial Ig-like domain; Region: Big_5; pfam13205
596154003886	Bacterial Ig-like domain; Region: Big_5; pfam13205
596154003887	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
596154003888	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
596154003889	MG2 domain; Region: A2M_N; pfam01835
596154003890	Alpha-2-macroglobulin family; Region: A2M; pfam00207
596154003891	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
596154003892	active site
596154003893	metal binding site [ion binding]; metal-binding site
596154003894	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154003895	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154003896	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154003897	dimerization interface [polypeptide binding]; other site
596154003898	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154003899	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
596154003900	active site
596154003901	homotetramer interface [polypeptide binding]; other site
596154003902	homodimer interface [polypeptide binding]; other site
596154003903	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154003904	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154003905	active site
596154003906	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
596154003907	CoA binding domain; Region: CoA_binding_2; pfam13380
596154003908	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
596154003909	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
596154003910	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154003911	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154003912	active site
596154003913	mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253
596154003914	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154003915	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
596154003916	substrate binding site [chemical binding]; other site
596154003917	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
596154003918	Transglycosylase; Region: Transgly; pfam00912
596154003919	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
596154003920	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
596154003921	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
596154003922	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154003923	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154003924	metal binding site [ion binding]; metal-binding site
596154003925	active site
596154003926	I-site; other site
596154003927	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
596154003928	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
596154003929	ligand binding site [chemical binding]; other site
596154003930	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
596154003931	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
596154003932	phosphate binding site [ion binding]; other site
596154003933	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154003934	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154003935	active site
596154003936	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154003937	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154003938	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154003939	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
596154003940	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154003941	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448
596154003942	putative dimerization interface [polypeptide binding]; other site
596154003943	putative substrate binding pocket [chemical binding]; other site
596154003944	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
596154003945	active site
596154003946	DNA polymerase IV; Validated; Region: PRK02406
596154003947	DNA binding site [nucleotide binding]
596154003948	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154003949	PAS domain; Region: PAS_9; pfam13426
596154003950	putative active site [active]
596154003951	heme pocket [chemical binding]; other site
596154003952	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
596154003953	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
596154003954	dimer interface [polypeptide binding]; other site
596154003955	putative CheW interface [polypeptide binding]; other site
596154003956	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
596154003957	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
596154003958	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
596154003959	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
596154003960	hypothetical protein; Validated; Region: PRK02101
596154003961	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
596154003962	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
596154003963	homodimer interface [polypeptide binding]; other site
596154003964	oligonucleotide binding site [chemical binding]; other site
596154003965	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
596154003966	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
596154003967	active site
596154003968	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
596154003969	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
596154003970	motif II; other site
596154003971	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
596154003972	iron-sulfur cluster [ion binding]; other site
596154003973	[2Fe-2S] cluster binding site [ion binding]; other site
596154003974	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
596154003975	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
596154003976	tandem repeat interface [polypeptide binding]; other site
596154003977	oligomer interface [polypeptide binding]; other site
596154003978	active site residues [active]
596154003979	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
596154003980	putative SAM binding site [chemical binding]; other site
596154003981	homodimer interface [polypeptide binding]; other site
596154003982	Maf-like protein; Region: Maf; pfam02545
596154003983	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
596154003984	active site
596154003985	dimer interface [polypeptide binding]; other site
596154003986	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
596154003987	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
596154003988	putative phosphate acyltransferase; Provisional; Region: PRK05331
596154003989	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
596154003990	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
596154003991	dimer interface [polypeptide binding]; other site
596154003992	active site
596154003993	CoA binding pocket [chemical binding]; other site
596154003994	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
596154003995	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
596154003996	gluconate 5-dehydrogenase; Provisional; Region: PRK06124
596154003997	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154003998	NAD(P) binding site [chemical binding]; other site
596154003999	active site
596154004000	acyl carrier protein; Provisional; Region: acpP; PRK00982
596154004001	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
596154004002	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
596154004003	dimer interface [polypeptide binding]; other site
596154004004	active site
596154004005	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
596154004006	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
596154004007	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
596154004008	DNA binding residues [nucleotide binding]
596154004009	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
596154004010	MucB/RseB family; Region: MucB_RseB; pfam03888
596154004011	anti-sigma E factor; Provisional; Region: rseB; PRK09455
596154004012	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
596154004013	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
596154004014	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
596154004015	protein binding site [polypeptide binding]; other site
596154004016	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
596154004017	protein binding site [polypeptide binding]; other site
596154004018	GTP-binding protein LepA; Provisional; Region: PRK05433
596154004019	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
596154004020	G1 box; other site
596154004021	putative GEF interaction site [polypeptide binding]; other site
596154004022	GTP/Mg2+ binding site [chemical binding]; other site
596154004023	Switch I region; other site
596154004024	G2 box; other site
596154004025	G3 box; other site
596154004026	Switch II region; other site
596154004027	G4 box; other site
596154004028	G5 box; other site
596154004029	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
596154004030	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
596154004031	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
596154004032	signal peptidase I; Provisional; Region: PRK10861
596154004033	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
596154004034	Catalytic site [active]
596154004035	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
596154004036	ribonuclease III; Reviewed; Region: rnc; PRK00102
596154004037	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
596154004038	dimerization interface [polypeptide binding]; other site
596154004039	active site
596154004040	metal binding site [ion binding]; metal-binding site
596154004041	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
596154004042	GTPase Era; Reviewed; Region: era; PRK00089
596154004043	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
596154004044	G1 box; other site
596154004045	GTP/Mg2+ binding site [chemical binding]; other site
596154004046	Switch I region; other site
596154004047	G2 box; other site
596154004048	Switch II region; other site
596154004049	G3 box; other site
596154004050	G4 box; other site
596154004051	G5 box; other site
596154004052	KH domain; Region: KH_2; pfam07650
596154004053	Recombination protein O N terminal; Region: RecO_N; pfam11967
596154004054	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
596154004055	Recombination protein O C terminal; Region: RecO_C; pfam02565
596154004056	pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265
596154004057	active site
596154004058	hydrophilic channel; other site
596154004059	dimerization interface [polypeptide binding]; other site
596154004060	catalytic residues [active]
596154004061	active site lid [active]
596154004062	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
596154004063	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
596154004064	beta-hexosaminidase; Provisional; Region: PRK05337
596154004065	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
596154004066	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
596154004067	active site
596154004068	ADP/pyrophosphate binding site [chemical binding]; other site
596154004069	dimerization interface [polypeptide binding]; other site
596154004070	allosteric effector site; other site
596154004071	fructose-1,6-bisphosphate binding site; other site
596154004072	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
596154004073	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
596154004074	Walker A/P-loop; other site
596154004075	ATP binding site [chemical binding]; other site
596154004076	Q-loop/lid; other site
596154004077	ABC transporter signature motif; other site
596154004078	Walker B; other site
596154004079	D-loop; other site
596154004080	H-loop/switch region; other site
596154004081	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
596154004082	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
596154004083	Walker A/P-loop; other site
596154004084	ATP binding site [chemical binding]; other site
596154004085	Q-loop/lid; other site
596154004086	ABC transporter signature motif; other site
596154004087	Walker B; other site
596154004088	D-loop; other site
596154004089	H-loop/switch region; other site
596154004090	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
596154004091	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
596154004092	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
596154004093	TM-ABC transporter signature motif; other site
596154004094	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154004095	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
596154004096	TM-ABC transporter signature motif; other site
596154004097	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
596154004098	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
596154004099	dimerization interface [polypeptide binding]; other site
596154004100	ligand binding site [chemical binding]; other site
596154004101	Mechanosensitive ion channel; Region: MS_channel; pfam00924
596154004102	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
596154004103	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
596154004104	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
596154004105	dimer interface [polypeptide binding]; other site
596154004106	putative anticodon binding site; other site
596154004107	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
596154004108	motif 1; other site
596154004109	active site
596154004110	motif 2; other site
596154004111	motif 3; other site
596154004112	Bacterial sugar transferase; Region: Bac_transf; pfam02397
596154004113	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
596154004114	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
596154004115	inhibitor-cofactor binding pocket; inhibition site
596154004116	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154004117	catalytic residue [active]
596154004118	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154004119	S-adenosylmethionine binding site [chemical binding]; other site
596154004120	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
596154004121	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
596154004122	Ligand binding site; other site
596154004123	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
596154004124	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
596154004125	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
596154004126	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
596154004127	trimer interface [polypeptide binding]; other site
596154004128	active site
596154004129	substrate binding site [chemical binding]; other site
596154004130	CoA binding site [chemical binding]; other site
596154004131	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
596154004132	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
596154004133	NAD(P) binding site [chemical binding]; other site
596154004134	homodimer interface [polypeptide binding]; other site
596154004135	substrate binding site [chemical binding]; other site
596154004136	active site
596154004137	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
596154004138	YGGT family; Region: YGGT; pfam02325
596154004139	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
596154004140	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
596154004141	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
596154004142	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
596154004143	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
596154004144	substrate binding site [chemical binding]; other site
596154004145	active site
596154004146	catalytic residues [active]
596154004147	heterodimer interface [polypeptide binding]; other site
596154004148	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
596154004149	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
596154004150	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154004151	catalytic residue [active]
596154004152	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
596154004153	active site
596154004154	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
596154004155	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
596154004156	dimerization interface 3.5A [polypeptide binding]; other site
596154004157	active site
596154004158	FimV N-terminal domain; Region: FimV_core; TIGR03505
596154004159	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
596154004160	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
596154004161	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
596154004162	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
596154004163	tartrate dehydrogenase; Region: TTC; TIGR02089
596154004164	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
596154004165	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
596154004166	substrate binding site [chemical binding]; other site
596154004167	Predicted small secreted protein [Function unknown]; Region: COG5510
596154004168	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
596154004169	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
596154004170	substrate binding site [chemical binding]; other site
596154004171	ligand binding site [chemical binding]; other site
596154004172	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154004173	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154004174	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
596154004175	putative dimerization interface [polypeptide binding]; other site
596154004176	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
596154004177	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
596154004178	Beta-Casp domain; Region: Beta-Casp; smart01027
596154004179	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
596154004180	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
596154004181	Cytochrome P450; Region: p450; cl12078
596154004182	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
596154004183	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
596154004184	Flavoprotein; Region: Flavoprotein; pfam02441
596154004185	DGC domain; Region: DGC; pfam08859
596154004186	SCP-2 sterol transfer family; Region: SCP2; cl01225
596154004187	putative protease; Provisional; Region: PRK15447
596154004188	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
596154004189	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
596154004190	Peptidase family U32; Region: Peptidase_U32; pfam01136
596154004191	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
596154004192	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
596154004193	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
596154004194	catalytic residue [active]
596154004195	chaperone protein DnaJ; Provisional; Region: PRK10767
596154004196	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
596154004197	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
596154004198	substrate binding site [polypeptide binding]; other site
596154004199	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
596154004200	Zn binding sites [ion binding]; other site
596154004201	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
596154004202	dimer interface [polypeptide binding]; other site
596154004203	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
596154004204	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
596154004205	nucleotide binding site [chemical binding]; other site
596154004206	GrpE; Region: GrpE; pfam01025
596154004207	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
596154004208	dimer interface [polypeptide binding]; other site
596154004209	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
596154004210	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
596154004211	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
596154004212	generic binding surface I; other site
596154004213	generic binding surface II; other site
596154004214	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
596154004215	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
596154004216	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
596154004217	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
596154004218	replicative DNA helicase; Region: DnaB; TIGR00665
596154004219	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
596154004220	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
596154004221	Walker A motif; other site
596154004222	ATP binding site [chemical binding]; other site
596154004223	Walker B motif; other site
596154004224	DNA binding loops [nucleotide binding]
596154004225	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
596154004226	aldehyde dehydrogenase family 7 member; Region: PLN02315
596154004227	tetrameric interface [polypeptide binding]; other site
596154004228	NAD binding site [chemical binding]; other site
596154004229	catalytic residues [active]
596154004230	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
596154004231	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
596154004232	putative active site [active]
596154004233	PhoH-like protein; Region: PhoH; pfam02562
596154004234	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
596154004235	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
596154004236	catalytic triad [active]
596154004237	Protein of unknown function (DUF3334); Region: DUF3334; pfam11813
596154004238	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
596154004239	YceI-like domain; Region: YceI; smart00867
596154004240	Uncharacterized conserved protein [Function unknown]; Region: COG2353
596154004241	malic enzyme; Reviewed; Region: PRK12862
596154004242	Malic enzyme, N-terminal domain; Region: malic; pfam00390
596154004243	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
596154004244	putative NAD(P) binding site [chemical binding]; other site
596154004245	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
596154004246	xanthine permease; Region: pbuX; TIGR03173
596154004247	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
596154004248	dimer interface [polypeptide binding]; other site
596154004249	putative CheW interface [polypeptide binding]; other site
596154004250	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
596154004251	M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697
596154004252	putative metal binding site [ion binding]; other site
596154004253	putative bifunctional OHCU decarboxylase/allantoate amidohydrolase; Provisional; Region: PRK13590
596154004254	OHCU decarboxylase; Region: OHCU_decarbox; pfam09349
596154004255	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
596154004256	active site
596154004257	metal binding site [ion binding]; metal-binding site
596154004258	dimer interface [polypeptide binding]; other site
596154004259	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
596154004260	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
596154004261	active site
596154004262	catalytic site [active]
596154004263	tetramer interface [polypeptide binding]; other site
596154004264	Transcriptional regulators [Transcription]; Region: GntR; COG1802
596154004265	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154004266	DNA-binding site [nucleotide binding]; DNA binding site
596154004267	FCD domain; Region: FCD; pfam07729
596154004268	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154004269	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154004270	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
596154004271	putative effector binding pocket; other site
596154004272	putative dimerization interface [polypeptide binding]; other site
596154004273	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
596154004274	tartrate dehydrogenase; Region: TTC; TIGR02089
596154004275	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154004276	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
596154004277	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
596154004278	MOFRL family; Region: MOFRL; pfam05161
596154004279	cell density-dependent motility repressor; Provisional; Region: PRK10082
596154004280	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154004281	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
596154004282	dimerization interface [polypeptide binding]; other site
596154004283	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
596154004284	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
596154004285	inhibitor-cofactor binding pocket; inhibition site
596154004286	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154004287	catalytic residue [active]
596154004288	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
596154004289	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
596154004290	substrate binding pocket [chemical binding]; other site
596154004291	membrane-bound complex binding site; other site
596154004292	hinge residues; other site
596154004293	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154004294	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154004295	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
596154004296	putative effector binding pocket; other site
596154004297	dimerization interface [polypeptide binding]; other site
596154004298	glyoxylate carboligase; Provisional; Region: PRK11269
596154004299	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
596154004300	PYR/PP interface [polypeptide binding]; other site
596154004301	dimer interface [polypeptide binding]; other site
596154004302	TPP binding site [chemical binding]; other site
596154004303	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
596154004304	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
596154004305	TPP-binding site [chemical binding]; other site
596154004306	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
596154004307	tartronate semialdehyde reductase; Provisional; Region: PRK15059
596154004308	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
596154004309	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
596154004310	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
596154004311	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
596154004312	active site
596154004313	homotetramer interface [polypeptide binding]; other site
596154004314	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
596154004315	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
596154004316	XdhC Rossmann domain; Region: XdhC_C; pfam13478
596154004317	Protein of unknown function (DUF989); Region: DUF989; pfam06181
596154004318	Predicted membrane protein [Function unknown]; Region: COG3748
596154004319	Cytochrome c; Region: Cytochrom_C; pfam00034
596154004320	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
596154004321	trimer interface [polypeptide binding]; other site
596154004322	active site
596154004323	Predicted metalloprotease [General function prediction only]; Region: COG2321
596154004324	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
596154004325	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
596154004326	DEAD-like helicases superfamily; Region: DEXDc; smart00487
596154004327	ATP binding site [chemical binding]; other site
596154004328	Mg++ binding site [ion binding]; other site
596154004329	motif III; other site
596154004330	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
596154004331	nucleotide binding region [chemical binding]; other site
596154004332	ATP-binding site [chemical binding]; other site
596154004333	NosL; Region: NosL; cl01769
596154004334	NosL; Region: NosL; pfam05573
596154004335	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
596154004336	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
596154004337	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
596154004338	Walker A/P-loop; other site
596154004339	ATP binding site [chemical binding]; other site
596154004340	Q-loop/lid; other site
596154004341	ABC transporter signature motif; other site
596154004342	Walker B; other site
596154004343	D-loop; other site
596154004344	H-loop/switch region; other site
596154004345	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
596154004346	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
596154004347	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
596154004348	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
596154004349	4Fe-4S binding domain; Region: Fer4_5; pfam12801
596154004350	4Fe-4S binding domain; Region: Fer4_5; pfam12801
596154004351	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
596154004352	nitrous-oxide reductase; Validated; Region: PRK02888
596154004353	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
596154004354	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
596154004355	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
596154004356	ApbE family; Region: ApbE; pfam02424
596154004357	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
596154004358	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
596154004359	active site
596154004360	metal binding site [ion binding]; metal-binding site
596154004361	H-NS histone family; Region: Histone_HNS; pfam00816
596154004362	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
596154004363	aconitate hydratase; Validated; Region: PRK09277
596154004364	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
596154004365	substrate binding site [chemical binding]; other site
596154004366	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
596154004367	ligand binding site [chemical binding]; other site
596154004368	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
596154004369	substrate binding site [chemical binding]; other site
596154004370	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
596154004371	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154004372	Major Facilitator Superfamily; Region: MFS_1; pfam07690
596154004373	putative substrate translocation pore; other site
596154004374	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154004375	Major Facilitator Superfamily; Region: MFS_1; pfam07690
596154004376	putative substrate translocation pore; other site
596154004377	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
596154004378	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154004379	active site
596154004380	phosphorylation site [posttranslational modification]
596154004381	intermolecular recognition site; other site
596154004382	dimerization interface [polypeptide binding]; other site
596154004383	LytTr DNA-binding domain; Region: LytTR; smart00850
596154004384	Histidine kinase; Region: His_kinase; pfam06580
596154004385	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
596154004386	ATP binding site [chemical binding]; other site
596154004387	Mg2+ binding site [ion binding]; other site
596154004388	G-X-G motif; other site
596154004389	2TM domain; Region: 2TM; pfam13239
596154004390	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
596154004391	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
596154004392	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
596154004393	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
596154004394	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
596154004395	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154004396	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
596154004397	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
596154004398	Protein export membrane protein; Region: SecD_SecF; cl14618
596154004399	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
596154004400	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
596154004401	MutS domain I; Region: MutS_I; pfam01624
596154004402	MutS domain II; Region: MutS_II; pfam05188
596154004403	MutS domain III; Region: MutS_III; pfam05192
596154004404	MutS domain V; Region: MutS_V; pfam00488
596154004405	Walker A/P-loop; other site
596154004406	ATP binding site [chemical binding]; other site
596154004407	Q-loop/lid; other site
596154004408	ABC transporter signature motif; other site
596154004409	Walker B; other site
596154004410	D-loop; other site
596154004411	H-loop/switch region; other site
596154004412	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154004413	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154004414	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
596154004415	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
596154004416	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154004417	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
596154004418	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
596154004419	phosphate binding site [ion binding]; other site
596154004420	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154004421	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154004422	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
596154004423	dimerization interface [polypeptide binding]; other site
596154004424	PhoD-like phosphatase; Region: PhoD; pfam09423
596154004425	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
596154004426	putative active site [active]
596154004427	putative metal binding site [ion binding]; other site
596154004428	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
596154004429	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154004430	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154004431	metal binding site [ion binding]; metal-binding site
596154004432	active site
596154004433	I-site; other site
596154004434	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
596154004435	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
596154004436	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154004437	S-adenosylmethionine binding site [chemical binding]; other site
596154004438	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
596154004439	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
596154004440	Peptidase family M23; Region: Peptidase_M23; pfam01551
596154004441	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
596154004442	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
596154004443	RNA binding surface [nucleotide binding]; other site
596154004444	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
596154004445	active site
596154004446	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
596154004447	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
596154004448	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
596154004449	RNA binding surface [nucleotide binding]; other site
596154004450	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
596154004451	probable active site [active]
596154004452	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
596154004453	active site
596154004454	multimer interface [polypeptide binding]; other site
596154004455	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
596154004456	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
596154004457	FeS/SAM binding site; other site
596154004458	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
596154004459	binding surface
596154004460	TPR motif; other site
596154004461	TPR repeat; Region: TPR_11; pfam13414
596154004462	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
596154004463	binding surface
596154004464	TPR motif; other site
596154004465	Helix-turn-helix domain; Region: HTH_25; pfam13413
596154004466	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
596154004467	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
596154004468	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
596154004469	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
596154004470	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
596154004471	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
596154004472	dimer interface [polypeptide binding]; other site
596154004473	motif 1; other site
596154004474	active site
596154004475	motif 2; other site
596154004476	motif 3; other site
596154004477	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
596154004478	anticodon binding site; other site
596154004479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
596154004480	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
596154004481	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
596154004482	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
596154004483	Trp docking motif [polypeptide binding]; other site
596154004484	active site
596154004485	GTP-binding protein Der; Reviewed; Region: PRK00093
596154004486	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
596154004487	G1 box; other site
596154004488	GTP/Mg2+ binding site [chemical binding]; other site
596154004489	Switch I region; other site
596154004490	G2 box; other site
596154004491	Switch II region; other site
596154004492	G3 box; other site
596154004493	G4 box; other site
596154004494	G5 box; other site
596154004495	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
596154004496	G1 box; other site
596154004497	GTP/Mg2+ binding site [chemical binding]; other site
596154004498	Switch I region; other site
596154004499	G2 box; other site
596154004500	G3 box; other site
596154004501	Switch II region; other site
596154004502	G4 box; other site
596154004503	G5 box; other site
596154004504	bacterial Hfq-like; Region: Hfq; cd01716
596154004505	hexamer interface [polypeptide binding]; other site
596154004506	Sm1 motif; other site
596154004507	RNA binding site [nucleotide binding]; other site
596154004508	Sm2 motif; other site
596154004509	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
596154004510	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
596154004511	HflX GTPase family; Region: HflX; cd01878
596154004512	G1 box; other site
596154004513	GTP/Mg2+ binding site [chemical binding]; other site
596154004514	Switch I region; other site
596154004515	G2 box; other site
596154004516	G3 box; other site
596154004517	Switch II region; other site
596154004518	G4 box; other site
596154004519	G5 box; other site
596154004520	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
596154004521	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
596154004522	HflK protein; Region: hflK; TIGR01933
596154004523	HflC protein; Region: hflC; TIGR01932
596154004524	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
596154004525	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
596154004526	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
596154004527	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
596154004528	dimer interface [polypeptide binding]; other site
596154004529	motif 1; other site
596154004530	active site
596154004531	motif 2; other site
596154004532	motif 3; other site
596154004533	adenylosuccinate synthetase; Provisional; Region: PRK01117
596154004534	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
596154004535	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
596154004536	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
596154004537	active site
596154004538	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
596154004539	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
596154004540	active site
596154004541	uracil binding [chemical binding]; other site
596154004542	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
596154004543	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
596154004544	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
596154004545	NodB motif; other site
596154004546	active site
596154004547	catalytic site [active]
596154004548	metal binding site [ion binding]; metal-binding site
596154004549	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
596154004550	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
596154004551	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
596154004552	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
596154004553	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
596154004554	putative MPT binding site; other site
596154004555	glutamine synthetase; Provisional; Region: glnA; PRK09469
596154004556	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
596154004557	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
596154004558	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
596154004559	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
596154004560	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154004561	dimer interface [polypeptide binding]; other site
596154004562	phosphorylation site [posttranslational modification]
596154004563	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154004564	ATP binding site [chemical binding]; other site
596154004565	Mg2+ binding site [ion binding]; other site
596154004566	G-X-G motif; other site
596154004567	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
596154004568	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154004569	active site
596154004570	phosphorylation site [posttranslational modification]
596154004571	intermolecular recognition site; other site
596154004572	dimerization interface [polypeptide binding]; other site
596154004573	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154004574	Walker A motif; other site
596154004575	ATP binding site [chemical binding]; other site
596154004576	Walker B motif; other site
596154004577	arginine finger; other site
596154004578	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
596154004579	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
596154004580	putative catalytic site [active]
596154004581	putative phosphate binding site [ion binding]; other site
596154004582	active site
596154004583	metal binding site A [ion binding]; metal-binding site
596154004584	DNA binding site [nucleotide binding]
596154004585	putative AP binding site [nucleotide binding]; other site
596154004586	putative metal binding site B [ion binding]; other site
596154004587	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
596154004588	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
596154004589	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
596154004590	Soluble P-type ATPase [General function prediction only]; Region: COG4087
596154004591	K+-transporting ATPase, c chain; Region: KdpC; cl00944
596154004592	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
596154004593	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
596154004594	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
596154004595	Ligand Binding Site [chemical binding]; other site
596154004596	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
596154004597	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154004598	dimer interface [polypeptide binding]; other site
596154004599	phosphorylation site [posttranslational modification]
596154004600	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154004601	ATP binding site [chemical binding]; other site
596154004602	Mg2+ binding site [ion binding]; other site
596154004603	G-X-G motif; other site
596154004604	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
596154004605	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154004606	active site
596154004607	phosphorylation site [posttranslational modification]
596154004608	intermolecular recognition site; other site
596154004609	dimerization interface [polypeptide binding]; other site
596154004610	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
596154004611	DNA binding site [nucleotide binding]
596154004612	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
596154004613	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
596154004614	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
596154004615	Protein of unknown function (DUF3348); Region: DUF3348; pfam11828
596154004616	Domain of unknown function (DUF802); Region: DUF802; pfam05650
596154004617	hypothetical protein; Provisional; Region: PRK09040
596154004618	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
596154004619	ligand binding site [chemical binding]; other site
596154004620	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
596154004621	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
596154004622	folate binding site [chemical binding]; other site
596154004623	NADP+ binding site [chemical binding]; other site
596154004624	thymidylate synthase; Reviewed; Region: thyA; PRK01827
596154004625	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
596154004626	dimerization interface [polypeptide binding]; other site
596154004627	active site
596154004628	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
596154004629	FAD binding domain; Region: FAD_binding_4; pfam01565
596154004630	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
596154004631	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
596154004632	Protein of unknown function (DUF2868); Region: DUF2868; pfam11067
596154004633	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
596154004634	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
596154004635	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
596154004636	dimer interface [polypeptide binding]; other site
596154004637	putative CheW interface [polypeptide binding]; other site
596154004638	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
596154004639	catalytic residues [active]
596154004640	substrate binding pocket [chemical binding]; other site
596154004641	substrate-Mg2+ binding site; other site
596154004642	aspartate-rich region 1; other site
596154004643	aspartate-rich region 2; other site
596154004644	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
596154004645	active site lid residues [active]
596154004646	substrate binding pocket [chemical binding]; other site
596154004647	catalytic residues [active]
596154004648	substrate-Mg2+ binding site; other site
596154004649	aspartate-rich region 1; other site
596154004650	aspartate-rich region 2; other site
596154004651	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
596154004652	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
596154004653	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154004654	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
596154004655	trigger factor; Provisional; Region: tig; PRK01490
596154004656	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
596154004657	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
596154004658	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
596154004659	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
596154004660	oligomer interface [polypeptide binding]; other site
596154004661	active site residues [active]
596154004662	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
596154004663	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
596154004664	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154004665	Walker A motif; other site
596154004666	ATP binding site [chemical binding]; other site
596154004667	Walker B motif; other site
596154004668	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
596154004669	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
596154004670	Found in ATP-dependent protease La (LON); Region: LON; smart00464
596154004671	Found in ATP-dependent protease La (LON); Region: LON; smart00464
596154004672	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154004673	Walker A motif; other site
596154004674	ATP binding site [chemical binding]; other site
596154004675	Walker B motif; other site
596154004676	arginine finger; other site
596154004677	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
596154004678	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154004679	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154004680	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
596154004681	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
596154004682	putative active site [active]
596154004683	putative catalytic site [active]
596154004684	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154004685	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
596154004686	active site
596154004687	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154004688	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154004689	putative CoA-transferase; Provisional; Region: PRK11430
596154004690	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154004691	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154004692	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
596154004693	SnoaL-like domain; Region: SnoaL_3; pfam13474
596154004694	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
596154004695	putative FMN binding site [chemical binding]; other site
596154004696	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
596154004697	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154004698	substrate binding site [chemical binding]; other site
596154004699	oxyanion hole (OAH) forming residues; other site
596154004700	trimer interface [polypeptide binding]; other site
596154004701	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154004702	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336
596154004703	putative ligand binding site [chemical binding]; other site
596154004704	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
596154004705	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154004706	TM-ABC transporter signature motif; other site
596154004707	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
596154004708	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
596154004709	TM-ABC transporter signature motif; other site
596154004710	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
596154004711	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
596154004712	Walker A/P-loop; other site
596154004713	ATP binding site [chemical binding]; other site
596154004714	Q-loop/lid; other site
596154004715	ABC transporter signature motif; other site
596154004716	Walker B; other site
596154004717	D-loop; other site
596154004718	H-loop/switch region; other site
596154004719	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
596154004720	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
596154004721	Walker A/P-loop; other site
596154004722	ATP binding site [chemical binding]; other site
596154004723	Q-loop/lid; other site
596154004724	ABC transporter signature motif; other site
596154004725	Walker B; other site
596154004726	D-loop; other site
596154004727	H-loop/switch region; other site
596154004728	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
596154004729	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
596154004730	phosphate binding site [ion binding]; other site
596154004731	short chain dehydrogenase; Provisional; Region: PRK06125
596154004732	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154004733	NAD(P) binding site [chemical binding]; other site
596154004734	active site
596154004735	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
596154004736	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154004737	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154004738	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154004739	dimerization interface [polypeptide binding]; other site
596154004740	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154004741	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154004742	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154004743	Thioesterase-like superfamily; Region: 4HBT_2; pfam13279
596154004744	active site 1 [active]
596154004745	active site 2 [active]
596154004746	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154004747	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154004748	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154004749	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154004750	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154004751	lipid-transfer protein; Provisional; Region: PRK08256
596154004752	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
596154004753	active site
596154004754	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
596154004755	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
596154004756	MoaC_like    Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: MaoC_like; cd03446
596154004757	homodimer interaction site [polypeptide binding]; other site
596154004758	putative active site [active]
596154004759	putative catalytic site [active]
596154004760	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154004761	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154004762	active site
596154004763	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
596154004764	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154004765	NAD(P) binding site [chemical binding]; other site
596154004766	active site
596154004767	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
596154004768	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154004769	substrate binding site [chemical binding]; other site
596154004770	oxyanion hole (OAH) forming residues; other site
596154004771	trimer interface [polypeptide binding]; other site
596154004772	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154004773	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154004774	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154004775	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154004776	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154004777	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154004778	dimerization interface [polypeptide binding]; other site
596154004779	choline dehydrogenase; Validated; Region: PRK02106
596154004780	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
596154004781	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154004782	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
596154004783	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
596154004784	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154004785	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
596154004786	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154004787	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154004788	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
596154004789	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154004790	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
596154004791	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
596154004792	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154004793	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154004794	active site
596154004795	enoyl-CoA hydratase; Region: PLN02864
596154004796	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
596154004797	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
596154004798	dimer interaction site [polypeptide binding]; other site
596154004799	substrate-binding tunnel; other site
596154004800	active site
596154004801	catalytic site [active]
596154004802	substrate binding site [chemical binding]; other site
596154004803	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
596154004804	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154004805	NAD(P) binding site [chemical binding]; other site
596154004806	active site
596154004807	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
596154004808	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
596154004809	dimer interface [polypeptide binding]; other site
596154004810	active site
596154004811	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
596154004812	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
596154004813	Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968
596154004814	acyl-activating enzyme (AAE) consensus motif; other site
596154004815	putative AMP binding site [chemical binding]; other site
596154004816	putative active site [active]
596154004817	putative CoA binding site [chemical binding]; other site
596154004818	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
596154004819	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154004820	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154004821	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154004822	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154004823	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
596154004824	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154004825	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154004826	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
596154004827	putative dimerization interface [polypeptide binding]; other site
596154004828	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154004829	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
596154004830	active site
596154004831	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
596154004832	Ligand binding site [chemical binding]; other site
596154004833	Electron transfer flavoprotein domain; Region: ETF; pfam01012
596154004834	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
596154004835	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
596154004836	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
596154004837	Uncharacterized conserved protein [Function unknown]; Region: COG3777
596154004838	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
596154004839	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
596154004840	active site 2 [active]
596154004841	active site 1 [active]
596154004842	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154004843	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154004844	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
596154004845	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
596154004846	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
596154004847	Walker A/P-loop; other site
596154004848	ATP binding site [chemical binding]; other site
596154004849	Q-loop/lid; other site
596154004850	ABC transporter signature motif; other site
596154004851	Walker B; other site
596154004852	D-loop; other site
596154004853	H-loop/switch region; other site
596154004854	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
596154004855	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
596154004856	Walker A/P-loop; other site
596154004857	ATP binding site [chemical binding]; other site
596154004858	Q-loop/lid; other site
596154004859	ABC transporter signature motif; other site
596154004860	Walker B; other site
596154004861	D-loop; other site
596154004862	H-loop/switch region; other site
596154004863	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
596154004864	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
596154004865	TM-ABC transporter signature motif; other site
596154004866	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154004867	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
596154004868	TM-ABC transporter signature motif; other site
596154004869	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154004870	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
596154004871	ligand binding site [chemical binding]; other site
596154004872	L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239
596154004873	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
596154004874	putative NAD(P) binding site [chemical binding]; other site
596154004875	catalytic Zn binding site [ion binding]; other site
596154004876	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
596154004877	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
596154004878	NAD(P) binding site [chemical binding]; other site
596154004879	catalytic residues [active]
596154004880	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154004881	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
596154004882	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
596154004883	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
596154004884	NAD(P) binding site [chemical binding]; other site
596154004885	catalytic residues [active]
596154004886	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
596154004887	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
596154004888	NAD(P) binding site [chemical binding]; other site
596154004889	catalytic residues [active]
596154004890	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
596154004891	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154004892	substrate binding site [chemical binding]; other site
596154004893	oxyanion hole (OAH) forming residues; other site
596154004894	trimer interface [polypeptide binding]; other site
596154004895	Transmembrane secretion effector; Region: MFS_3; pfam05977
596154004896	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
596154004897	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
596154004898	trimer interface [polypeptide binding]; other site
596154004899	eyelet of channel; other site
596154004900	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154004901	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154004902	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
596154004903	TM-ABC transporter signature motif; other site
596154004904	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
596154004905	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
596154004906	TM-ABC transporter signature motif; other site
596154004907	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
596154004908	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
596154004909	Walker A/P-loop; other site
596154004910	ATP binding site [chemical binding]; other site
596154004911	Q-loop/lid; other site
596154004912	ABC transporter signature motif; other site
596154004913	Walker B; other site
596154004914	D-loop; other site
596154004915	H-loop/switch region; other site
596154004916	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
596154004917	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
596154004918	Walker A/P-loop; other site
596154004919	ATP binding site [chemical binding]; other site
596154004920	Q-loop/lid; other site
596154004921	ABC transporter signature motif; other site
596154004922	Walker B; other site
596154004923	D-loop; other site
596154004924	H-loop/switch region; other site
596154004925	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154004926	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336
596154004927	putative ligand binding site [chemical binding]; other site
596154004928	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
596154004929	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154004930	Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935
596154004931	acyl-activating enzyme (AAE) consensus motif; other site
596154004932	putative AMP binding site [chemical binding]; other site
596154004933	putative active site [active]
596154004934	putative CoA binding site [chemical binding]; other site
596154004935	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154004936	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
596154004937	FAD binding site [chemical binding]; other site
596154004938	substrate binding site [chemical binding]; other site
596154004939	catalytic base [active]
596154004940	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
596154004941	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154004942	NAD(P) binding site [chemical binding]; other site
596154004943	active site
596154004944	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
596154004945	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154004946	H-NS histone family; Region: Histone_HNS; pfam00816
596154004947	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
596154004948	Integrase core domain; Region: rve; pfam00665
596154004949	Integrase core domain; Region: rve_3; pfam13683
596154004950	Part of AAA domain; Region: AAA_19; pfam13245
596154004951	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
596154004952	Transposase; Region: HTH_Tnp_1; cl17663
596154004953	Transposase domain (DUF772); Region: DUF772; pfam05598
596154004954	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
596154004955	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
596154004956	Transposase domain (DUF772); Region: DUF772; pfam05598
596154004957	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
596154004958	DDE superfamily endonuclease; Region: DDE_4; cl17710
596154004959	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
596154004960	Helix-turn-helix domain; Region: HTH_38; pfam13936
596154004961	Homeodomain-like domain; Region: HTH_32; pfam13565
596154004962	Integrase core domain; Region: rve; pfam00665
596154004963	Uncharacterized conserved small protein [Function unknown]; Region: COG5639
596154004964	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
596154004965	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
596154004966	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
596154004967	VirB7 interaction site; other site
596154004968	conjugal transfer protein TrbF; Provisional; Region: PRK13872
596154004969	conjugal transfer protein TrbL; Provisional; Region: PRK13875
596154004970	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
596154004971	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
596154004972	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314
596154004973	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
596154004974	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
596154004975	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
596154004976	Walker A motif; other site
596154004977	ATP binding site [chemical binding]; other site
596154004978	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
596154004979	Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268
596154004980	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
596154004981	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
596154004982	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
596154004983	ATP binding site [chemical binding]; other site
596154004984	Walker A motif; other site
596154004985	hexamer interface [polypeptide binding]; other site
596154004986	Walker B motif; other site
596154004987	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
596154004988	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
596154004989	Walker A motif; other site
596154004990	ATP binding site [chemical binding]; other site
596154004991	Walker B motif; other site
596154004992	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154004993	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154004994	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
596154004995	dimerization interface [polypeptide binding]; other site
596154004996	substrate binding pocket [chemical binding]; other site
596154004997	hypothetical protein; Provisional; Region: PRK07236
596154004998	hypothetical protein; Provisional; Region: PRK07588
596154004999	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
596154005000	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
596154005001	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
596154005002	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
596154005003	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
596154005004	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
596154005005	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
596154005006	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
596154005007	Walker A/P-loop; other site
596154005008	ATP binding site [chemical binding]; other site
596154005009	Q-loop/lid; other site
596154005010	ABC transporter signature motif; other site
596154005011	Walker B; other site
596154005012	D-loop; other site
596154005013	H-loop/switch region; other site
596154005014	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
596154005015	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
596154005016	Walker A/P-loop; other site
596154005017	ATP binding site [chemical binding]; other site
596154005018	Q-loop/lid; other site
596154005019	ABC transporter signature motif; other site
596154005020	Walker B; other site
596154005021	D-loop; other site
596154005022	H-loop/switch region; other site
596154005023	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
596154005024	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154005025	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154005026	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154005027	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
596154005028	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
596154005029	PGAP1-like protein; Region: PGAP1; pfam07819
596154005030	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
596154005031	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
596154005032	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
596154005033	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
596154005034	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
596154005035	ParA-like protein; Provisional; Region: PHA02518
596154005036	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
596154005037	P-loop; other site
596154005038	Magnesium ion binding site [ion binding]; other site
596154005039	Replication initiator protein A; Region: RPA; pfam10134
596154005040	Helix-turn-helix domain; Region: HTH_17; cl17695
596154005041	Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246
596154005042	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
596154005043	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154005044	non-specific DNA binding site [nucleotide binding]; other site
596154005045	salt bridge; other site
596154005046	sequence-specific DNA binding site [nucleotide binding]; other site
596154005047	Uncharacterized conserved protein [Function unknown]; Region: COG5489
596154005048	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
596154005049	putative DNA binding site [nucleotide binding]; other site
596154005050	putative Zn2+ binding site [ion binding]; other site
596154005051	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
596154005052	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
596154005053	putative metal binding site [ion binding]; other site
596154005054	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
596154005055	Low molecular weight phosphatase family; Region: LMWPc; cd00115
596154005056	active site
596154005057	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
596154005058	arsenical-resistance protein; Region: acr3; TIGR00832
596154005059	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
596154005060	ArsC family; Region: ArsC; pfam03960
596154005061	catalytic residues [active]
596154005062	Predicted transcriptional regulators [Transcription]; Region: COG1695
596154005063	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
596154005064	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
596154005065	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
596154005066	Chromate transporter; Region: Chromate_transp; pfam02417
596154005067	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
596154005068	Coenzyme A binding pocket [chemical binding]; other site
596154005069	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
596154005070	ParB-like nuclease domain; Region: ParBc; pfam02195
596154005071	Domain of unknown function (DUF932); Region: DUF932; pfam06067
596154005072	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
596154005073	hypothetical protein; Reviewed; Region: PRK00024
596154005074	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
596154005075	MPN+ (JAMM) motif; other site
596154005076	Zinc-binding site [ion binding]; other site
596154005077	TIR domain; Region: TIR_2; pfam13676
596154005078	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
596154005079	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035
596154005080	putative uracil binding site [chemical binding]; other site
596154005081	putative active site [active]
596154005082	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
596154005083	putative metal binding site [ion binding]; other site
596154005084	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
596154005085	Predicted transcriptional regulator [Transcription]; Region: COG2944
596154005086	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154005087	non-specific DNA binding site [nucleotide binding]; other site
596154005088	salt bridge; other site
596154005089	sequence-specific DNA binding site [nucleotide binding]; other site
596154005090	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
596154005091	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
596154005092	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
596154005093	active site
596154005094	Int/Topo IB signature motif; other site
596154005095	DNA binding site [nucleotide binding]
596154005096	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
596154005097	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
596154005098	GIY-YIG motif/motif A; other site
596154005099	active site
596154005100	catalytic site [active]
596154005101	putative DNA binding site [nucleotide binding]; other site
596154005102	metal binding site [ion binding]; metal-binding site
596154005103	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
596154005104	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
596154005105	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
596154005106	IHF dimer interface [polypeptide binding]; other site
596154005107	IHF - DNA interface [nucleotide binding]; other site
596154005108	SurA N-terminal domain; Region: SurA_N_3; cl07813
596154005109	periplasmic folding chaperone; Provisional; Region: PRK10788
596154005110	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
596154005111	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154005112	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
596154005113	putative ligand binding site [chemical binding]; other site
596154005114	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
596154005115	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154005116	substrate binding site [chemical binding]; other site
596154005117	oxyanion hole (OAH) forming residues; other site
596154005118	trimer interface [polypeptide binding]; other site
596154005119	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
596154005120	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
596154005121	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154005122	acyl-activating enzyme (AAE) consensus motif; other site
596154005123	active site
596154005124	AMP binding site [chemical binding]; other site
596154005125	CoA binding site [chemical binding]; other site
596154005126	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
596154005127	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
596154005128	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
596154005129	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
596154005130	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
596154005131	ATP-grasp domain; Region: ATP-grasp_4; cl17255
596154005132	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
596154005133	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
596154005134	carboxyltransferase (CT) interaction site; other site
596154005135	biotinylation site [posttranslational modification]; other site
596154005136	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
596154005137	active site
596154005138	catalytic residues [active]
596154005139	metal binding site [ion binding]; metal-binding site
596154005140	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
596154005141	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154005142	acyl-activating enzyme (AAE) consensus motif; other site
596154005143	AMP binding site [chemical binding]; other site
596154005144	active site
596154005145	CoA binding site [chemical binding]; other site
596154005146	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154005147	enoyl-CoA hydratase; Provisional; Region: PRK05995
596154005148	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154005149	substrate binding site [chemical binding]; other site
596154005150	oxyanion hole (OAH) forming residues; other site
596154005151	trimer interface [polypeptide binding]; other site
596154005152	cysteine synthase B; Region: cysM; TIGR01138
596154005153	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
596154005154	dimer interface [polypeptide binding]; other site
596154005155	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154005156	catalytic residue [active]
596154005157	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
596154005158	nudix motif; other site
596154005159	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
596154005160	CPxP  motif; other site
596154005161	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
596154005162	active site
596154005163	tetramer interface; other site
596154005164	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
596154005165	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
596154005166	HIGH motif; other site
596154005167	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
596154005168	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
596154005169	active site
596154005170	KMSKS motif; other site
596154005171	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
596154005172	tRNA binding surface [nucleotide binding]; other site
596154005173	anticodon binding site; other site
596154005174	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
596154005175	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
596154005176	Cytochrome c; Region: Cytochrom_C; pfam00034
596154005177	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
596154005178	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
596154005179	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
596154005180	D-pathway; other site
596154005181	Low-spin heme binding site [chemical binding]; other site
596154005182	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
596154005183	Putative water exit pathway; other site
596154005184	Binuclear center (active site) [active]
596154005185	K-pathway; other site
596154005186	Putative proton exit pathway; other site
596154005187	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
596154005188	bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975
596154005189	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
596154005190	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
596154005191	active site
596154005192	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
596154005193	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
596154005194	domain interfaces; other site
596154005195	active site
596154005196	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
596154005197	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
596154005198	transcriptional activator FlhC; Provisional; Region: PRK12722
596154005199	Flagellar transcriptional activator (FlhD); Region: FlhD; pfam05247
596154005200	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
596154005201	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
596154005202	heme binding site [chemical binding]; other site
596154005203	ferroxidase pore; other site
596154005204	ferroxidase diiron center [ion binding]; other site
596154005205	peroxiredoxin; Region: AhpC; TIGR03137
596154005206	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
596154005207	dimer interface [polypeptide binding]; other site
596154005208	decamer (pentamer of dimers) interface [polypeptide binding]; other site
596154005209	catalytic triad [active]
596154005210	peroxidatic and resolving cysteines [active]
596154005211	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
596154005212	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
596154005213	catalytic residue [active]
596154005214	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
596154005215	catalytic residues [active]
596154005216	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
596154005217	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
596154005218	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
596154005219	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
596154005220	tetramer interface [polypeptide binding]; other site
596154005221	heme binding pocket [chemical binding]; other site
596154005222	NADPH binding site [chemical binding]; other site
596154005223	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
596154005224	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154005225	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
596154005226	PEP synthetase regulatory protein; Provisional; Region: PRK05339
596154005227	phosphoenolpyruvate synthase; Validated; Region: PRK06464
596154005228	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
596154005229	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
596154005230	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
596154005231	Domain of unknown function (DUF4212); Region: DUF4212; cl01781
596154005232	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
596154005233	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
596154005234	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
596154005235	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154005236	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154005237	active site
596154005238	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
596154005239	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
596154005240	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
596154005241	SurA N-terminal domain; Region: SurA_N; pfam09312
596154005242	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
596154005243	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154005244	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
596154005245	putative ligand binding site [chemical binding]; other site
596154005246	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154005247	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154005248	active site
596154005249	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154005250	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154005251	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
596154005252	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
596154005253	dimer interface [polypeptide binding]; other site
596154005254	acyl-activating enzyme (AAE) consensus motif; other site
596154005255	putative active site [active]
596154005256	AMP binding site [chemical binding]; other site
596154005257	putative CoA binding site [chemical binding]; other site
596154005258	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
596154005259	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
596154005260	dimer interface [polypeptide binding]; other site
596154005261	active site
596154005262	enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674
596154005263	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154005264	substrate binding site [chemical binding]; other site
596154005265	oxyanion hole (OAH) forming residues; other site
596154005266	trimer interface [polypeptide binding]; other site
596154005267	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154005268	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
596154005269	NAD(P) binding site [chemical binding]; other site
596154005270	active site
596154005271	elongation factor P; Validated; Region: PRK00529
596154005272	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
596154005273	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
596154005274	RNA binding site [nucleotide binding]; other site
596154005275	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
596154005276	RNA binding site [nucleotide binding]; other site
596154005277	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
596154005278	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154005279	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154005280	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
596154005281	putative dimerization interface [polypeptide binding]; other site
596154005282	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154005283	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154005284	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
596154005285	active site
596154005286	catalytic residues [active]
596154005287	metal binding site [ion binding]; metal-binding site
596154005288	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154005289	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154005290	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154005291	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154005292	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
596154005293	putative substrate binding pocket [chemical binding]; other site
596154005294	dimerization interface [polypeptide binding]; other site
596154005295	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154005296	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154005297	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154005298	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154005299	active site
596154005300	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
596154005301	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
596154005302	substrate binding pocket [chemical binding]; other site
596154005303	membrane-bound complex binding site; other site
596154005304	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
596154005305	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154005306	dimer interface [polypeptide binding]; other site
596154005307	conserved gate region; other site
596154005308	putative PBP binding loops; other site
596154005309	ABC-ATPase subunit interface; other site
596154005310	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
596154005311	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
596154005312	Walker A/P-loop; other site
596154005313	ATP binding site [chemical binding]; other site
596154005314	Q-loop/lid; other site
596154005315	ABC transporter signature motif; other site
596154005316	Walker B; other site
596154005317	D-loop; other site
596154005318	H-loop/switch region; other site
596154005319	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
596154005320	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154005321	DNA-binding site [nucleotide binding]; DNA binding site
596154005322	UTRA domain; Region: UTRA; pfam07702
596154005323	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
596154005324	active sites [active]
596154005325	tetramer interface [polypeptide binding]; other site
596154005326	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
596154005327	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154005328	DNA-binding site [nucleotide binding]; DNA binding site
596154005329	UTRA domain; Region: UTRA; pfam07702
596154005330	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
596154005331	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
596154005332	Na binding site [ion binding]; other site
596154005333	urocanate hydratase; Provisional; Region: PRK05414
596154005334	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154005335	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
596154005336	putative DNA binding site [nucleotide binding]; other site
596154005337	putative Zn2+ binding site [ion binding]; other site
596154005338	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154005339	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
596154005340	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
596154005341	substrate binding pocket [chemical binding]; other site
596154005342	membrane-bound complex binding site; other site
596154005343	hinge residues; other site
596154005344	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
596154005345	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154005346	putative PBP binding loops; other site
596154005347	dimer interface [polypeptide binding]; other site
596154005348	ABC-ATPase subunit interface; other site
596154005349	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
596154005350	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
596154005351	Walker A/P-loop; other site
596154005352	ATP binding site [chemical binding]; other site
596154005353	Q-loop/lid; other site
596154005354	ABC transporter signature motif; other site
596154005355	Walker B; other site
596154005356	D-loop; other site
596154005357	H-loop/switch region; other site
596154005358	HutD; Region: HutD; pfam05962
596154005359	imidazolonepropionase; Validated; Region: PRK09356
596154005360	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
596154005361	active site
596154005362	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
596154005363	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
596154005364	active site
596154005365	N-formylglutamate amidohydrolase; Region: FGase; cl01522
596154005366	glutamate racemase; Provisional; Region: PRK00865
596154005367	Methyltransferase domain; Region: Methyltransf_23; pfam13489
596154005368	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154005369	S-adenosylmethionine binding site [chemical binding]; other site
596154005370	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
596154005371	succinic semialdehyde dehydrogenase; Region: PLN02278
596154005372	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
596154005373	tetramerization interface [polypeptide binding]; other site
596154005374	NAD(P) binding site [chemical binding]; other site
596154005375	catalytic residues [active]
596154005376	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
596154005377	galactarate dehydratase; Region: galactar-dH20; TIGR03248
596154005378	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
596154005379	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154005380	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
596154005381	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154005382	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154005383	dimerization interface [polypeptide binding]; other site
596154005384	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
596154005385	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
596154005386	active site
596154005387	nucleophile elbow; other site
596154005388	tartrate dehydrogenase; Region: TTC; TIGR02089
596154005389	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
596154005390	transcriptional activator TtdR; Provisional; Region: PRK09801
596154005391	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154005392	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
596154005393	putative effector binding pocket; other site
596154005394	putative dimerization interface [polypeptide binding]; other site
596154005395	tellurium resistance terB-like protein; Region: terB_like; cd07177
596154005396	metal binding site [ion binding]; metal-binding site
596154005397	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
596154005398	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
596154005399	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
596154005400	IHF - DNA interface [nucleotide binding]; other site
596154005401	IHF dimer interface [polypeptide binding]; other site
596154005402	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154005403	non-specific DNA binding site [nucleotide binding]; other site
596154005404	salt bridge; other site
596154005405	sequence-specific DNA binding site [nucleotide binding]; other site
596154005406	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154005407	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154005408	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
596154005409	dimerization interface [polypeptide binding]; other site
596154005410	substrate binding pocket [chemical binding]; other site
596154005411	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
596154005412	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
596154005413	NAD(P) binding site [chemical binding]; other site
596154005414	homotetramer interface [polypeptide binding]; other site
596154005415	homodimer interface [polypeptide binding]; other site
596154005416	active site
596154005417	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
596154005418	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
596154005419	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
596154005420	division inhibitor protein; Provisional; Region: slmA; PRK09480
596154005421	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154005422	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
596154005423	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
596154005424	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
596154005425	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154005426	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
596154005427	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
596154005428	Walker A/P-loop; other site
596154005429	ATP binding site [chemical binding]; other site
596154005430	Q-loop/lid; other site
596154005431	ABC transporter signature motif; other site
596154005432	Walker B; other site
596154005433	D-loop; other site
596154005434	H-loop/switch region; other site
596154005435	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
596154005436	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
596154005437	Walker A/P-loop; other site
596154005438	ATP binding site [chemical binding]; other site
596154005439	Q-loop/lid; other site
596154005440	ABC transporter signature motif; other site
596154005441	Walker B; other site
596154005442	D-loop; other site
596154005443	H-loop/switch region; other site
596154005444	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
596154005445	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
596154005446	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
596154005447	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
596154005448	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
596154005449	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
596154005450	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
596154005451	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
596154005452	Beta-Casp domain; Region: Beta-Casp; smart01027
596154005453	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
596154005454	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
596154005455	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
596154005456	Cytochrome C' Region: Cytochrom_C_2; cl01610
596154005457	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
596154005458	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154005459	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
596154005460	dimerization interface [polypeptide binding]; other site
596154005461	substrate binding pocket [chemical binding]; other site
596154005462	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
596154005463	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
596154005464	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
596154005465	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
596154005466	Magnesium ion binding site [ion binding]; other site
596154005467	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
596154005468	ParB-like nuclease domain; Region: ParBc; pfam02195
596154005469	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
596154005470	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
596154005471	PLD-like domain; Region: PLDc_2; pfam13091
596154005472	homodimer interface [polypeptide binding]; other site
596154005473	putative active site [active]
596154005474	catalytic site [active]
596154005475	Domain of unknown function (DUF1845); Region: DUF1845; pfam08900
596154005476	Protein of unknown function (DUF3158); Region: DUF3158; pfam11358
596154005477	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
596154005478	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
596154005479	dimer interface [polypeptide binding]; other site
596154005480	ssDNA binding site [nucleotide binding]; other site
596154005481	tetramer (dimer of dimers) interface [polypeptide binding]; other site
596154005482	DNA topoisomerase III; Provisional; Region: PRK07726
596154005483	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
596154005484	active site
596154005485	putative interdomain interaction site [polypeptide binding]; other site
596154005486	putative metal-binding site [ion binding]; other site
596154005487	putative nucleotide binding site [chemical binding]; other site
596154005488	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
596154005489	domain I; other site
596154005490	DNA binding groove [nucleotide binding]
596154005491	phosphate binding site [ion binding]; other site
596154005492	domain II; other site
596154005493	domain III; other site
596154005494	nucleotide binding site [chemical binding]; other site
596154005495	catalytic site [active]
596154005496	domain IV; other site
596154005497	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
596154005498	Protein of unknown function (DUF3085); Region: DUF3085; pfam11284
596154005499	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
596154005500	Protein of unknown function (DUF3275); Region: DUF3275; pfam11679
596154005501	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154005502	S-adenosylmethionine binding site [chemical binding]; other site
596154005503	DEAD-like helicases superfamily; Region: DEXDc; smart00487
596154005504	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
596154005505	nucleotide binding region [chemical binding]; other site
596154005506	ATP-binding site [chemical binding]; other site
596154005507	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
596154005508	Chromate transporter; Region: Chromate_transp; pfam02417
596154005509	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
596154005510	Chromate transporter; Region: Chromate_transp; pfam02417
596154005511	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
596154005512	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
596154005513	putative transposase OrfB; Reviewed; Region: PHA02517
596154005514	HTH-like domain; Region: HTH_21; pfam13276
596154005515	Integrase core domain; Region: rve; pfam00665
596154005516	Integrase core domain; Region: rve_3; cl15866
596154005517	Transposase; Region: HTH_Tnp_1; cl17663
596154005518	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
596154005519	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
596154005520	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
596154005521	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
596154005522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154005523	active site
596154005524	phosphorylation site [posttranslational modification]
596154005525	intermolecular recognition site; other site
596154005526	dimerization interface [polypeptide binding]; other site
596154005527	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
596154005528	DNA binding site [nucleotide binding]
596154005529	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
596154005530	dimerization interface [polypeptide binding]; other site
596154005531	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154005532	dimer interface [polypeptide binding]; other site
596154005533	phosphorylation site [posttranslational modification]
596154005534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154005535	ATP binding site [chemical binding]; other site
596154005536	Mg2+ binding site [ion binding]; other site
596154005537	G-X-G motif; other site
596154005538	NHL repeat; Region: NHL; pfam01436
596154005539	NHL repeat; Region: NHL; pfam01436
596154005540	NHL repeat; Region: NHL; pfam01436
596154005541	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
596154005542	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154005543	heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
596154005544	Walker A/P-loop; other site
596154005545	ATP binding site [chemical binding]; other site
596154005546	Q-loop/lid; other site
596154005547	ABC transporter signature motif; other site
596154005548	Walker B; other site
596154005549	D-loop; other site
596154005550	H-loop/switch region; other site
596154005551	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353
596154005552	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353
596154005553	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
596154005554	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
596154005555	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
596154005556	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
596154005557	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
596154005558	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
596154005559	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
596154005560	ABC transporter signature motif; other site
596154005561	Walker B; other site
596154005562	D-loop; other site
596154005563	H-loop/switch region; other site
596154005564	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
596154005565	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
596154005566	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
596154005567	DNA methylase; Region: N6_N4_Mtase; pfam01555
596154005568	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
596154005569	active site residue [active]
596154005570	AIPR protein; Region: AIPR; pfam10592
596154005571	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
596154005572	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
596154005573	active site
596154005574	catalytic triad [active]
596154005575	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154005576	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
596154005577	Walker A motif; other site
596154005578	ATP binding site [chemical binding]; other site
596154005579	Walker B motif; other site
596154005580	arginine finger; other site
596154005581	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
596154005582	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
596154005583	ATP binding site [chemical binding]; other site
596154005584	putative Mg++ binding site [ion binding]; other site
596154005585	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
596154005586	nucleotide binding region [chemical binding]; other site
596154005587	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
596154005588	ATP-binding site [chemical binding]; other site
596154005589	Helix-turn-helix domain; Region: HTH_17; pfam12728
596154005590	integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690
596154005591	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
596154005592	Protein of unknown function (DUF3262); Region: DUF3262; pfam11660
596154005593	integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745
596154005594	Protein of unknown function (DUF3487); Region: DUF3487; pfam11990
596154005595	integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746
596154005596	Protein of unknown function (DUF3438); Region: DUF3438; pfam11920
596154005597	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
596154005598	Protein of unknown function (DUF904); Region: DUF904; pfam06005
596154005599	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
596154005600	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
596154005601	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
596154005602	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
596154005603	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
596154005604	catalytic residues [active]
596154005605	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
596154005606	MPN+ (JAMM) motif; other site
596154005607	Zinc-binding site [ion binding]; other site
596154005608	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
596154005609	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154005610	S-adenosylmethionine binding site [chemical binding]; other site
596154005611	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
596154005612	Protein of unknown function (DUF1525); Region: DUF1525; pfam07511
596154005613	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
596154005614	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
596154005615	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
596154005616	Protein of unknown function (DUF3742); Region: DUF3742; pfam12553
596154005617	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
596154005618	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
596154005619	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
596154005620	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
596154005621	Putative helicase; Region: TraI_2; pfam07514
596154005622	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
596154005623	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
596154005624	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154005625	non-specific DNA binding site [nucleotide binding]; other site
596154005626	salt bridge; other site
596154005627	sequence-specific DNA binding site [nucleotide binding]; other site
596154005628	LysR substrate binding domain; Region: LysR_substrate; pfam03466
596154005629	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
596154005630	active site
596154005631	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
596154005632	Heavy-metal-associated domain; Region: HMA; pfam00403
596154005633	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
596154005634	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
596154005635	metal-binding site [ion binding]
596154005636	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
596154005637	Soluble P-type ATPase [General function prediction only]; Region: COG4087
596154005638	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
596154005639	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
596154005640	DNA binding residues [nucleotide binding]
596154005641	dimer interface [polypeptide binding]; other site
596154005642	putative metal binding site [ion binding]; other site
596154005643	integrase; Provisional; Region: PRK09692
596154005644	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
596154005645	active site
596154005646	Int/Topo IB signature motif; other site
596154005647	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
596154005648	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
596154005649	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
596154005650	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
596154005651	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
596154005652	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
596154005653	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924
596154005654	Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795
596154005655	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
596154005656	Transposase; Region: HTH_Tnp_1; pfam01527
596154005657	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
596154005658	HTH-like domain; Region: HTH_21; pfam13276
596154005659	Integrase core domain; Region: rve; pfam00665
596154005660	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154005661	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154005662	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154005663	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154005664	active site
596154005665	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154005666	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154005667	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154005668	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
596154005669	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
596154005670	active site
596154005671	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
596154005672	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154005673	active site
596154005674	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
596154005675	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
596154005676	DUF35 OB-fold domain; Region: DUF35; pfam01796
596154005677	acetyl-CoA acetyltransferase; Provisional; Region: PRK08142
596154005678	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
596154005679	active site
596154005680	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154005681	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
596154005682	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154005683	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
596154005684	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154005685	NAD(P) binding site [chemical binding]; other site
596154005686	active site
596154005687	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
596154005688	CoA binding domain; Region: CoA_binding_2; pfam13380
596154005689	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
596154005690	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
596154005691	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
596154005692	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154005693	substrate binding site [chemical binding]; other site
596154005694	oxyanion hole (OAH) forming residues; other site
596154005695	trimer interface [polypeptide binding]; other site
596154005696	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154005697	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
596154005698	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
596154005699	active site
596154005700	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154005701	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
596154005702	active site
596154005703	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154005704	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154005705	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154005706	enoyl-CoA hydratase; Region: PLN02864
596154005707	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
596154005708	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
596154005709	dimer interaction site [polypeptide binding]; other site
596154005710	substrate-binding tunnel; other site
596154005711	active site
596154005712	catalytic site [active]
596154005713	substrate binding site [chemical binding]; other site
596154005714	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154005715	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
596154005716	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
596154005717	Ligand binding site [chemical binding]; other site
596154005718	Electron transfer flavoprotein domain; Region: ETF; pfam01012
596154005719	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
596154005720	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
596154005721	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
596154005722	enoyl-CoA hydratase; Provisional; Region: PRK06688
596154005723	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154005724	substrate binding site [chemical binding]; other site
596154005725	oxyanion hole (OAH) forming residues; other site
596154005726	trimer interface [polypeptide binding]; other site
596154005727	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
596154005728	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
596154005729	FMN binding site [chemical binding]; other site
596154005730	substrate binding site [chemical binding]; other site
596154005731	putative catalytic residue [active]
596154005732	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154005733	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
596154005734	Putative serine esterase (DUF676); Region: DUF676; pfam05057
596154005735	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154005736	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154005737	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
596154005738	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
596154005739	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
596154005740	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154005741	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154005742	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154005743	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154005744	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154005745	active site
596154005746	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
596154005747	active site 2 [active]
596154005748	active site 1 [active]
596154005749	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
596154005750	active site 2 [active]
596154005751	active site 1 [active]
596154005752	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154005753	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
596154005754	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154005755	substrate binding site [chemical binding]; other site
596154005756	oxyanion hole (OAH) forming residues; other site
596154005757	trimer interface [polypeptide binding]; other site
596154005758	enoyl-CoA hydratase; Provisional; Region: PRK09245
596154005759	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154005760	substrate binding site [chemical binding]; other site
596154005761	oxyanion hole (OAH) forming residues; other site
596154005762	trimer interface [polypeptide binding]; other site
596154005763	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
596154005764	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154005765	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154005766	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
596154005767	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154005768	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154005769	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
596154005770	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
596154005771	ATP-grasp domain; Region: ATP-grasp_4; cl17255
596154005772	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
596154005773	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
596154005774	carboxyltransferase (CT) interaction site; other site
596154005775	biotinylation site [posttranslational modification]; other site
596154005776	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
596154005777	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
596154005778	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
596154005779	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
596154005780	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
596154005781	CoenzymeA binding site [chemical binding]; other site
596154005782	subunit interaction site [polypeptide binding]; other site
596154005783	PHB binding site; other site
596154005784	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
596154005785	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154005786	Walker A motif; other site
596154005787	ATP binding site [chemical binding]; other site
596154005788	Walker B motif; other site
596154005789	arginine finger; other site
596154005790	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
596154005791	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154005792	non-specific DNA binding site [nucleotide binding]; other site
596154005793	salt bridge; other site
596154005794	sequence-specific DNA binding site [nucleotide binding]; other site
596154005795	Integrase core domain; Region: rve; pfam00665
596154005796	Protein of unknown function (DUF3158); Region: DUF3158; pfam11358
596154005797	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
596154005798	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
596154005799	dimer interface [polypeptide binding]; other site
596154005800	ssDNA binding site [nucleotide binding]; other site
596154005801	tetramer (dimer of dimers) interface [polypeptide binding]; other site
596154005802	DNA topoisomerase III; Provisional; Region: PRK07726
596154005803	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
596154005804	active site
596154005805	putative interdomain interaction site [polypeptide binding]; other site
596154005806	putative metal-binding site [ion binding]; other site
596154005807	putative nucleotide binding site [chemical binding]; other site
596154005808	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
596154005809	domain I; other site
596154005810	DNA binding groove [nucleotide binding]
596154005811	phosphate binding site [ion binding]; other site
596154005812	domain II; other site
596154005813	domain III; other site
596154005814	nucleotide binding site [chemical binding]; other site
596154005815	catalytic site [active]
596154005816	domain IV; other site
596154005817	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
596154005818	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
596154005819	ArsC family; Region: ArsC; pfam03960
596154005820	catalytic residues [active]
596154005821	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
596154005822	Coenzyme A binding pocket [chemical binding]; other site
596154005823	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
596154005824	arsenical-resistance protein; Region: acr3; TIGR00832
596154005825	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
596154005826	Low molecular weight phosphatase family; Region: LMWPc; cl00105
596154005827	active site
596154005828	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
596154005829	putative metal binding site [ion binding]; other site
596154005830	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
596154005831	putative DNA binding site [nucleotide binding]; other site
596154005832	putative Zn2+ binding site [ion binding]; other site
596154005833	Protein of unknown function (DUF3085); Region: DUF3085; pfam11284
596154005834	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
596154005835	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
596154005836	Active Sites [active]
596154005837	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
596154005838	Protein of unknown function (DUF3275); Region: DUF3275; pfam11679
596154005839	isoleucine-tRNA ligase, putative; Provisional; Region: PTZ00427
596154005840	Domain of unknown function (DUF932); Region: DUF932; pfam06067
596154005841	Methyltransferase domain; Region: Methyltransf_26; pfam13659
596154005842	S-adenosylmethionine binding site [chemical binding]; other site
596154005843	DEAD-like helicases superfamily; Region: DEXDc; smart00487
596154005844	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
596154005845	nucleotide binding region [chemical binding]; other site
596154005846	ATP-binding site [chemical binding]; other site
596154005847	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
596154005848	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
596154005849	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
596154005850	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
596154005851	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
596154005852	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
596154005853	integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690
596154005854	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
596154005855	Protein of unknown function (DUF3262); Region: DUF3262; pfam11660
596154005856	integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745
596154005857	Protein of unknown function (DUF3487); Region: DUF3487; pfam11990
596154005858	integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746
596154005859	Protein of unknown function (DUF3438); Region: DUF3438; pfam11920
596154005860	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
596154005861	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
596154005862	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
596154005863	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
596154005864	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
596154005865	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
596154005866	catalytic residues [active]
596154005867	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154005868	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154005869	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
596154005870	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
596154005871	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154005872	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
596154005873	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
596154005874	FtsX-like permease family; Region: FtsX; pfam02687
596154005875	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
596154005876	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
596154005877	Walker A/P-loop; other site
596154005878	ATP binding site [chemical binding]; other site
596154005879	Q-loop/lid; other site
596154005880	ABC transporter signature motif; other site
596154005881	Walker B; other site
596154005882	D-loop; other site
596154005883	H-loop/switch region; other site
596154005884	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
596154005885	Integrase core domain; Region: rve; pfam00665
596154005886	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
596154005887	Bacterial TniB protein; Region: TniB; pfam05621
596154005888	TniQ; Region: TniQ; pfam06527
596154005889	Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509
596154005890	Phosphotransferase enzyme family; Region: APH; pfam01636
596154005891	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
596154005892	active site
596154005893	ATP binding site [chemical binding]; other site
596154005894	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
596154005895	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
596154005896	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154005897	Walker A/P-loop; other site
596154005898	ATP binding site [chemical binding]; other site
596154005899	Q-loop/lid; other site
596154005900	ABC transporter signature motif; other site
596154005901	Walker B; other site
596154005902	D-loop; other site
596154005903	H-loop/switch region; other site
596154005904	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
596154005905	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
596154005906	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154005907	Walker A/P-loop; other site
596154005908	ATP binding site [chemical binding]; other site
596154005909	Q-loop/lid; other site
596154005910	ABC transporter signature motif; other site
596154005911	Walker B; other site
596154005912	D-loop; other site
596154005913	H-loop/switch region; other site
596154005914	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
596154005915	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
596154005916	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
596154005917	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
596154005918	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
596154005919	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
596154005920	active site residue [active]
596154005921	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
596154005922	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
596154005923	Chromate transporter; Region: Chromate_transp; pfam02417
596154005924	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
596154005925	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
596154005926	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
596154005927	Presynaptic Site I dimer interface [polypeptide binding]; other site
596154005928	catalytic residues [active]
596154005929	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
596154005930	Synaptic Flat tetramer interface [polypeptide binding]; other site
596154005931	Synaptic Site I dimer interface [polypeptide binding]; other site
596154005932	DNA binding site [nucleotide binding]
596154005933	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
596154005934	DNA-binding interface [nucleotide binding]; DNA binding site
596154005935	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
596154005936	Domain of unknown function (DUF3330); Region: DUF3330; pfam11809
596154005937	putative mercury resistance protein; Provisional; Region: PRK13747
596154005938	transcriptional regulator MerD; Provisional; Region: PRK13749
596154005939	Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111
596154005940	DNA binding residues [nucleotide binding]
596154005941	putative dimer interface [polypeptide binding]; other site
596154005942	putative mercuric reductase; Provisional; Region: PRK13748
596154005943	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
596154005944	metal-binding site [ion binding]
596154005945	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
596154005946	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
596154005947	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
596154005948	putative mercury transport protein MerC; Provisional; Region: PRK13755
596154005949	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
596154005950	metal-binding site [ion binding]
596154005951	putative mercuric transport protein; Provisional; Region: PRK13751
596154005952	putative transcriptional regulator MerR; Provisional; Region: PRK13752
596154005953	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
596154005954	DNA binding residues [nucleotide binding]
596154005955	dimer interface [polypeptide binding]; other site
596154005956	mercury binding site [ion binding]; other site
596154005957	Protein of unknown function (DUF1525); Region: DUF1525; pfam07511
596154005958	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
596154005959	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
596154005960	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
596154005961	Protein of unknown function (DUF3742); Region: DUF3742; pfam12553
596154005962	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
596154005963	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
596154005964	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
596154005965	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
596154005966	Putative helicase; Region: TraI_2; pfam07514
596154005967	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
596154005968	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
596154005969	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154005970	non-specific DNA binding site [nucleotide binding]; other site
596154005971	salt bridge; other site
596154005972	sequence-specific DNA binding site [nucleotide binding]; other site
596154005973	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154005974	LysR substrate binding domain; Region: LysR_substrate; pfam03466
596154005975	dimerization interface [polypeptide binding]; other site
596154005976	integrase; Provisional; Region: PRK09692
596154005977	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
596154005978	active site
596154005979	Int/Topo IB signature motif; other site
596154005980	Transcriptional regulator; Region: Rrf2; cl17282
596154005981	Rrf2 family protein; Region: rrf2_super; TIGR00738
596154005982	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
596154005983	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
596154005984	HPP family; Region: HPP; pfam04982
596154005985	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
596154005986	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
596154005987	rRNA binding site [nucleotide binding]; other site
596154005988	predicted 30S ribosome binding site; other site
596154005989	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154005990	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154005991	metal binding site [ion binding]; metal-binding site
596154005992	active site
596154005993	I-site; other site
596154005994	Protein of unknown function (DUF1624); Region: DUF1624; pfam07786
596154005995	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
596154005996	IHF dimer interface [polypeptide binding]; other site
596154005997	IHF - DNA interface [nucleotide binding]; other site
596154005998	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
596154005999	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
596154006000	RNA binding site [nucleotide binding]; other site
596154006001	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
596154006002	RNA binding site [nucleotide binding]; other site
596154006003	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
596154006004	RNA binding site [nucleotide binding]; other site
596154006005	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
596154006006	RNA binding site [nucleotide binding]; other site
596154006007	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
596154006008	RNA binding site [nucleotide binding]; other site
596154006009	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
596154006010	RNA binding site [nucleotide binding]; other site
596154006011	bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidine monophosphate kinase; Provisional; Region: PRK11860
596154006012	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
596154006013	hinge; other site
596154006014	active site
596154006015	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
596154006016	CMP-binding site; other site
596154006017	The sites determining sugar specificity; other site
596154006018	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
596154006019	prephenate dehydrogenase; Validated; Region: PRK08507
596154006020	Chorismate mutase type II; Region: CM_2; pfam01817
596154006021	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
596154006022	Prephenate dehydratase; Region: PDT; pfam00800
596154006023	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
596154006024	putative L-Phe binding site [chemical binding]; other site
596154006025	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
596154006026	homodimer interface [polypeptide binding]; other site
596154006027	substrate-cofactor binding pocket; other site
596154006028	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154006029	catalytic residue [active]
596154006030	DNA gyrase subunit A; Validated; Region: PRK05560
596154006031	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
596154006032	CAP-like domain; other site
596154006033	active site
596154006034	primary dimer interface [polypeptide binding]; other site
596154006035	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
596154006036	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
596154006037	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
596154006038	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
596154006039	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
596154006040	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
596154006041	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
596154006042	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
596154006043	ligand binding site [chemical binding]; other site
596154006044	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
596154006045	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154006046	S-adenosylmethionine binding site [chemical binding]; other site
596154006047	phosphoglycolate phosphatase; Provisional; Region: PRK13222
596154006048	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
596154006049	motif II; other site
596154006050	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154006051	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154006052	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154006053	dimerization interface [polypeptide binding]; other site
596154006054	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
596154006055	Thermostable Phosphite Dehydrogenase; Region: PTDH; cd12157
596154006056	homodimer interface [polypeptide binding]; other site
596154006057	ligand binding site [chemical binding]; other site
596154006058	NAD binding site [chemical binding]; other site
596154006059	catalytic site [active]
596154006060	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
596154006061	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154006062	dimer interface [polypeptide binding]; other site
596154006063	conserved gate region; other site
596154006064	putative PBP binding loops; other site
596154006065	ABC-ATPase subunit interface; other site
596154006066	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
596154006067	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
596154006068	substrate binding pocket [chemical binding]; other site
596154006069	membrane-bound complex binding site; other site
596154006070	hinge residues; other site
596154006071	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
596154006072	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
596154006073	Walker A/P-loop; other site
596154006074	ATP binding site [chemical binding]; other site
596154006075	Q-loop/lid; other site
596154006076	ABC transporter signature motif; other site
596154006077	Walker B; other site
596154006078	D-loop; other site
596154006079	H-loop/switch region; other site
596154006080	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
596154006081	putative metal binding site [ion binding]; other site
596154006082	Uncharacterized conserved protein [Function unknown]; Region: COG1432
596154006083	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
596154006084	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
596154006085	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
596154006086	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
596154006087	catalytic residues [active]
596154006088	catalytic nucleophile [active]
596154006089	Presynaptic Site I dimer interface [polypeptide binding]; other site
596154006090	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
596154006091	Synaptic Flat tetramer interface [polypeptide binding]; other site
596154006092	Synaptic Site I dimer interface [polypeptide binding]; other site
596154006093	DNA binding site [nucleotide binding]
596154006094	Recombinase; Region: Recombinase; pfam07508
596154006095	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
596154006096	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
596154006097	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
596154006098	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154006099	non-specific DNA binding site [nucleotide binding]; other site
596154006100	salt bridge; other site
596154006101	sequence-specific DNA binding site [nucleotide binding]; other site
596154006102	Helix-turn-helix domain; Region: HTH_17; cl17695
596154006103	AAA domain; Region: AAA_24; pfam13479
596154006104	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
596154006105	P63C domain; Region: P63C; pfam10546
596154006106	hypothetical protein; Validated; Region: PRK07078
596154006107	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
596154006108	active site
596154006109	metal binding site [ion binding]; metal-binding site
596154006110	interdomain interaction site; other site
596154006111	D5 N terminal like; Region: D5_N; smart00885
596154006112	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
596154006113	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
596154006114	ParB-like nuclease domain; Region: ParBc; pfam02195
596154006115	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
596154006116	DNA methylase; Region: N6_N4_Mtase; pfam01555
596154006117	ParB-like nuclease domain; Region: ParBc; pfam02195
596154006118	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
596154006119	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
596154006120	DNA methylase; Region: N6_N4_Mtase; pfam01555
596154006121	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
596154006122	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
596154006123	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
596154006124	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
596154006125	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
596154006126	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
596154006127	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
596154006128	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
596154006129	tandem repeat interface [polypeptide binding]; other site
596154006130	oligomer interface [polypeptide binding]; other site
596154006131	active site residues [active]
596154006132	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
596154006133	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
596154006134	Phage-related minor tail protein [Function unknown]; Region: COG5281
596154006135	tape measure domain; Region: tape_meas_nterm; TIGR02675
596154006136	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
596154006137	catalytic residue [active]
596154006138	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2958
596154006139	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
596154006140	active site
596154006141	NTP binding site [chemical binding]; other site
596154006142	metal binding triad [ion binding]; metal-binding site
596154006143	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
596154006144	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
596154006145	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
596154006146	ATP binding site [chemical binding]; other site
596154006147	putative Mg++ binding site [ion binding]; other site
596154006148	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
596154006149	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
596154006150	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
596154006151	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
596154006152	HsdM N-terminal domain; Region: HsdM_N; pfam12161
596154006153	Methyltransferase domain; Region: Methyltransf_26; pfam13659
596154006154	Uncharacterized conserved protein [Function unknown]; Region: COG1479
596154006155	Protein of unknown function DUF262; Region: DUF262; pfam03235
596154006156	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
596154006157	WYL domain; Region: WYL; pfam13280
596154006158	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
596154006159	catalytic residues [active]
596154006160	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
596154006161	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
596154006162	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
596154006163	protein binding site [polypeptide binding]; other site
596154006164	Peptidase family M48; Region: Peptidase_M48; cl12018
596154006165	Phosphate-starvation-inducible E; Region: PsiE; cl01264
596154006166	thioredoxin 2; Provisional; Region: PRK10996
596154006167	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
596154006168	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
596154006169	catalytic residues [active]
596154006170	FtsH Extracellular; Region: FtsH_ext; pfam06480
596154006171	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
596154006172	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154006173	Walker A motif; other site
596154006174	ATP binding site [chemical binding]; other site
596154006175	Walker B motif; other site
596154006176	arginine finger; other site
596154006177	Peptidase family M41; Region: Peptidase_M41; pfam01434
596154006178	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
596154006179	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
596154006180	putative active site [active]
596154006181	catalytic site [active]
596154006182	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
596154006183	putative active site [active]
596154006184	catalytic site [active]
596154006185	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
596154006186	Clp amino terminal domain; Region: Clp_N; pfam02861
596154006187	Clp amino terminal domain; Region: Clp_N; pfam02861
596154006188	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154006189	Walker A motif; other site
596154006190	ATP binding site [chemical binding]; other site
596154006191	Walker B motif; other site
596154006192	arginine finger; other site
596154006193	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154006194	Walker A motif; other site
596154006195	ATP binding site [chemical binding]; other site
596154006196	Walker B motif; other site
596154006197	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
596154006198	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
596154006199	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
596154006200	putative dimer interface [polypeptide binding]; other site
596154006201	Helix-turn-helix domain; Region: HTH_17; pfam12728
596154006202	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
596154006203	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
596154006204	Catalytic site [active]
596154006205	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
596154006206	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
596154006207	active site
596154006208	DNA binding site [nucleotide binding]
596154006209	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
596154006210	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
596154006211	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
596154006212	catalytic residues [active]
596154006213	catalytic nucleophile [active]
596154006214	Presynaptic Site I dimer interface [polypeptide binding]; other site
596154006215	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
596154006216	Synaptic Flat tetramer interface [polypeptide binding]; other site
596154006217	Synaptic Site I dimer interface [polypeptide binding]; other site
596154006218	DNA binding site [nucleotide binding]
596154006219	Recombinase; Region: Recombinase; pfam07508
596154006220	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
596154006221	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
596154006222	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154006223	non-specific DNA binding site [nucleotide binding]; other site
596154006224	salt bridge; other site
596154006225	sequence-specific DNA binding site [nucleotide binding]; other site
596154006226	Transposase; Region: HTH_Tnp_1; cl17663
596154006227	putative transposase OrfB; Reviewed; Region: PHA02517
596154006228	HTH-like domain; Region: HTH_21; pfam13276
596154006229	Integrase core domain; Region: rve; pfam00665
596154006230	Integrase core domain; Region: rve_3; cl15866
596154006231	glutaminase; Provisional; Region: PRK00971
596154006232	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
596154006233	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
596154006234	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
596154006235	metal binding site [ion binding]; metal-binding site
596154006236	putative dimer interface [polypeptide binding]; other site
596154006237	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154006238	metabolite-proton symporter; Region: 2A0106; TIGR00883
596154006239	putative substrate translocation pore; other site
596154006240	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154006241	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154006242	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
596154006243	dimerization interface [polypeptide binding]; other site
596154006244	Helix-turn-helix domain; Region: HTH_17; pfam12728
596154006245	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
596154006246	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
596154006247	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154006248	Major Facilitator Superfamily; Region: MFS_1; pfam07690
596154006249	putative substrate translocation pore; other site
596154006250	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
596154006251	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154006252	NAD(P) binding site [chemical binding]; other site
596154006253	active site
596154006254	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
596154006255	CoenzymeA binding site [chemical binding]; other site
596154006256	subunit interaction site [polypeptide binding]; other site
596154006257	PHB binding site; other site
596154006258	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
596154006259	Prostaglandin dehydrogenases; Region: PGDH; cd05288
596154006260	NAD(P) binding site [chemical binding]; other site
596154006261	substrate binding site [chemical binding]; other site
596154006262	dimer interface [polypeptide binding]; other site
596154006263	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
596154006264	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
596154006265	C-terminal domain interface [polypeptide binding]; other site
596154006266	GSH binding site (G-site) [chemical binding]; other site
596154006267	dimer interface [polypeptide binding]; other site
596154006268	Glutathione S-transferase, C-terminal domain; Region: GST_C_2; pfam13410
596154006269	N-terminal domain interface [polypeptide binding]; other site
596154006270	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
596154006271	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
596154006272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154006273	putative substrate translocation pore; other site
596154006274	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
596154006275	DNA photolyase; Region: DNA_photolyase; pfam00875
596154006276	Predicted integral membrane protein [Function unknown]; Region: COG5615
596154006277	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
596154006278	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
596154006279	THF binding site; other site
596154006280	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
596154006281	substrate binding site [chemical binding]; other site
596154006282	THF binding site; other site
596154006283	zinc-binding site [ion binding]; other site
596154006284	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
596154006285	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154006286	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
596154006287	putative dimerization interface [polypeptide binding]; other site
596154006288	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
596154006289	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
596154006290	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
596154006291	tetramer interface [polypeptide binding]; other site
596154006292	active site
596154006293	Mg2+/Mn2+ binding site [ion binding]; other site
596154006294	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
596154006295	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
596154006296	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
596154006297	substrate binding site [chemical binding]; other site
596154006298	ligand binding site [chemical binding]; other site
596154006299	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
596154006300	substrate binding site [chemical binding]; other site
596154006301	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
596154006302	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
596154006303	dimer interface [polypeptide binding]; other site
596154006304	active site
596154006305	citrylCoA binding site [chemical binding]; other site
596154006306	oxalacetate/citrate binding site [chemical binding]; other site
596154006307	coenzyme A binding site [chemical binding]; other site
596154006308	catalytic triad [active]
596154006309	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
596154006310	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
596154006311	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154006312	sequence-specific DNA binding site [nucleotide binding]; other site
596154006313	salt bridge; other site
596154006314	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
596154006315	Domain of unknown function (DUF955); Region: DUF955; pfam06114
596154006316	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
596154006317	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154006318	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154006319	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
596154006320	putative dimerization interface [polypeptide binding]; other site
596154006321	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
596154006322	dimer interface [polypeptide binding]; other site
596154006323	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
596154006324	metal binding site [ion binding]; metal-binding site
596154006325	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-1; cd12808
596154006326	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
596154006327	catalytic site [active]
596154006328	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
596154006329	RNA binding surface [nucleotide binding]; other site
596154006330	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
596154006331	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
596154006332	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154006333	dimer interface [polypeptide binding]; other site
596154006334	phosphorylation site [posttranslational modification]
596154006335	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154006336	ATP binding site [chemical binding]; other site
596154006337	Mg2+ binding site [ion binding]; other site
596154006338	G-X-G motif; other site
596154006339	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
596154006340	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154006341	active site
596154006342	phosphorylation site [posttranslational modification]
596154006343	intermolecular recognition site; other site
596154006344	dimerization interface [polypeptide binding]; other site
596154006345	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
596154006346	DNA binding site [nucleotide binding]
596154006347	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154006348	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
596154006349	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
596154006350	3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605
596154006351	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
596154006352	putative inner membrane protein; Provisional; Region: PRK11099
596154006353	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
596154006354	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
596154006355	active site residue [active]
596154006356	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
596154006357	active site residue [active]
596154006358	ferrochelatase; Reviewed; Region: hemH; PRK00035
596154006359	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
596154006360	C-terminal domain interface [polypeptide binding]; other site
596154006361	active site
596154006362	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
596154006363	active site
596154006364	N-terminal domain interface [polypeptide binding]; other site
596154006365	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
596154006366	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
596154006367	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
596154006368	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
596154006369	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
596154006370	Soluble P-type ATPase [General function prediction only]; Region: COG4087
596154006371	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
596154006372	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
596154006373	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
596154006374	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134
596154006375	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
596154006376	homodimer interface [polypeptide binding]; other site
596154006377	substrate-cofactor binding pocket; other site
596154006378	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154006379	catalytic residue [active]
596154006380	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
596154006381	FOG: CBS domain [General function prediction only]; Region: COG0517
596154006382	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
596154006383	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
596154006384	Tetramer interface [polypeptide binding]; other site
596154006385	active site
596154006386	FMN-binding site [chemical binding]; other site
596154006387	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
596154006388	ATP cone domain; Region: ATP-cone; pfam03477
596154006389	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
596154006390	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
596154006391	dimer interface [polypeptide binding]; other site
596154006392	active site
596154006393	glycine-pyridoxal phosphate binding site [chemical binding]; other site
596154006394	folate binding site [chemical binding]; other site
596154006395	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
596154006396	N-acetyl-D-glucosamine binding site [chemical binding]; other site
596154006397	catalytic residue [active]
596154006398	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
596154006399	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
596154006400	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
596154006401	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
596154006402	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
596154006403	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
596154006404	ribonuclease R; Region: RNase_R; TIGR02063
596154006405	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
596154006406	RNB domain; Region: RNB; pfam00773
596154006407	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
596154006408	RNA binding site [nucleotide binding]; other site
596154006409	classical (c) SDRs; Region: SDR_c; cd05233
596154006410	NAD(P) binding site [chemical binding]; other site
596154006411	active site
596154006412	Cytochrome c; Region: Cytochrom_C; cl11414
596154006413	Cytochrome c; Region: Cytochrom_C; cl11414
596154006414	Cytochrome c; Region: Cytochrom_C; pfam00034
596154006415	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
596154006416	Cytochrome c; Region: Cytochrom_C; pfam00034
596154006417	Cytochrome c; Region: Cytochrom_C; pfam00034
596154006418	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
596154006419	catalytic residues [active]
596154006420	ribosome maturation protein RimP; Reviewed; Region: PRK00092
596154006421	Sm and related proteins; Region: Sm_like; cl00259
596154006422	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
596154006423	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
596154006424	NusA N-terminal domain; Region: NusA_N; pfam08529
596154006425	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
596154006426	RNA binding site [nucleotide binding]; other site
596154006427	homodimer interface [polypeptide binding]; other site
596154006428	NusA-like KH domain; Region: KH_5; pfam13184
596154006429	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
596154006430	G-X-X-G motif; other site
596154006431	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
596154006432	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
596154006433	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
596154006434	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
596154006435	translation initiation factor IF-2; Region: IF-2; TIGR00487
596154006436	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
596154006437	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
596154006438	G1 box; other site
596154006439	putative GEF interaction site [polypeptide binding]; other site
596154006440	GTP/Mg2+ binding site [chemical binding]; other site
596154006441	Switch I region; other site
596154006442	G2 box; other site
596154006443	G3 box; other site
596154006444	Switch II region; other site
596154006445	G4 box; other site
596154006446	G5 box; other site
596154006447	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
596154006448	Translation-initiation factor 2; Region: IF-2; pfam11987
596154006449	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
596154006450	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
596154006451	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851
596154006452	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
596154006453	RNA binding site [nucleotide binding]; other site
596154006454	active site
596154006455	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
596154006456	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
596154006457	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
596154006458	G1 box; other site
596154006459	putative GEF interaction site [polypeptide binding]; other site
596154006460	GTP/Mg2+ binding site [chemical binding]; other site
596154006461	Switch I region; other site
596154006462	G2 box; other site
596154006463	G3 box; other site
596154006464	Switch II region; other site
596154006465	G4 box; other site
596154006466	G5 box; other site
596154006467	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
596154006468	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
596154006469	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
596154006470	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
596154006471	Leucine carboxyl methyltransferase; Region: LCM; cl01306
596154006472	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
596154006473	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154006474	substrate binding site [chemical binding]; other site
596154006475	oxyanion hole (OAH) forming residues; other site
596154006476	trimer interface [polypeptide binding]; other site
596154006477	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
596154006478	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
596154006479	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
596154006480	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
596154006481	DNA binding residues [nucleotide binding]
596154006482	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
596154006483	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
596154006484	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
596154006485	SmpB-tmRNA interface; other site
596154006486	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
596154006487	putative coenzyme Q binding site [chemical binding]; other site
596154006488	RnfH family Ubiquitin; Region: Ub-RnfH; cl17382
596154006489	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
596154006490	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
596154006491	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
596154006492	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
596154006493	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
596154006494	active site
596154006495	GMP synthase; Reviewed; Region: guaA; PRK00074
596154006496	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
596154006497	AMP/PPi binding site [chemical binding]; other site
596154006498	candidate oxyanion hole; other site
596154006499	catalytic triad [active]
596154006500	potential glutamine specificity residues [chemical binding]; other site
596154006501	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
596154006502	ATP Binding subdomain [chemical binding]; other site
596154006503	Ligand Binding sites [chemical binding]; other site
596154006504	Dimerization subdomain; other site
596154006505	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
596154006506	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154006507	non-specific DNA binding site [nucleotide binding]; other site
596154006508	salt bridge; other site
596154006509	sequence-specific DNA binding site [nucleotide binding]; other site
596154006510	Integrase core domain; Region: rve; pfam00665
596154006511	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
596154006512	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154006513	Walker A motif; other site
596154006514	ATP binding site [chemical binding]; other site
596154006515	Walker B motif; other site
596154006516	arginine finger; other site
596154006517	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
596154006518	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
596154006519	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
596154006520	pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188
596154006521	Int/Topo IB signature motif; other site
596154006522	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
596154006523	Domain of unknown function (DUF932); Region: DUF932; pfam06067
596154006524	ParB-like nuclease domain; Region: ParBc; pfam02195
596154006525	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
596154006526	metal-binding site [ion binding]
596154006527	MerT mercuric transport protein; Region: MerT; cl03578
596154006528	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
596154006529	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
596154006530	DNA binding residues [nucleotide binding]
596154006531	dimer interface [polypeptide binding]; other site
596154006532	mercury binding site [ion binding]; other site
596154006533	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
596154006534	EamA-like transporter family; Region: EamA; pfam00892
596154006535	Uncharacterized conserved protein [Function unknown]; Region: COG5489
596154006536	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154006537	non-specific DNA binding site [nucleotide binding]; other site
596154006538	salt bridge; other site
596154006539	sequence-specific DNA binding site [nucleotide binding]; other site
596154006540	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
596154006541	Transposase; Region: HTH_Tnp_1; cl17663
596154006542	putative transposase OrfB; Reviewed; Region: PHA02517
596154006543	HTH-like domain; Region: HTH_21; pfam13276
596154006544	Integrase core domain; Region: rve; pfam00665
596154006545	Integrase core domain; Region: rve_3; cl15866
596154006546	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
596154006547	Helix-turn-helix domain; Region: HTH_17; cl17695
596154006548	Replication initiator protein A; Region: RPA; pfam10134
596154006549	ParA-like protein; Provisional; Region: PHA02518
596154006550	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
596154006551	P-loop; other site
596154006552	Magnesium ion binding site [ion binding]; other site
596154006553	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
596154006554	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
596154006555	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
596154006556	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
596154006557	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
596154006558	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
596154006559	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
596154006560	Multicopper oxidase; Region: Cu-oxidase; pfam00394
596154006561	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
596154006562	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
596154006563	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
596154006564	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
596154006565	dimerization interface [polypeptide binding]; other site
596154006566	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154006567	dimer interface [polypeptide binding]; other site
596154006568	phosphorylation site [posttranslational modification]
596154006569	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154006570	ATP binding site [chemical binding]; other site
596154006571	Mg2+ binding site [ion binding]; other site
596154006572	G-X-G motif; other site
596154006573	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
596154006574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154006575	active site
596154006576	phosphorylation site [posttranslational modification]
596154006577	intermolecular recognition site; other site
596154006578	dimerization interface [polypeptide binding]; other site
596154006579	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
596154006580	DNA binding site [nucleotide binding]
596154006581	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
596154006582	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
596154006583	Multicopper oxidase; Region: Cu-oxidase; pfam00394
596154006584	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
596154006585	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
596154006586	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
596154006587	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
596154006588	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
596154006589	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
596154006590	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
596154006591	metal-binding site [ion binding]
596154006592	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
596154006593	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
596154006594	Cytochrome c; Region: Cytochrom_C; pfam00034
596154006595	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
596154006596	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
596154006597	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
596154006598	motif II; other site
596154006599	Outer membrane efflux protein; Region: OEP; pfam02321
596154006600	Outer membrane efflux protein; Region: OEP; pfam02321
596154006601	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
596154006602	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154006603	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
596154006604	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
596154006605	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
596154006606	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154006607	Walker A motif; other site
596154006608	ATP binding site [chemical binding]; other site
596154006609	Walker B motif; other site
596154006610	arginine finger; other site
596154006611	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
596154006612	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154006613	non-specific DNA binding site [nucleotide binding]; other site
596154006614	salt bridge; other site
596154006615	sequence-specific DNA binding site [nucleotide binding]; other site
596154006616	Integrase core domain; Region: rve; pfam00665
596154006617	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
596154006618	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
596154006619	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
596154006620	dimer interface [polypeptide binding]; other site
596154006621	active site
596154006622	citrylCoA binding site [chemical binding]; other site
596154006623	NADH binding [chemical binding]; other site
596154006624	cationic pore residues; other site
596154006625	oxalacetate/citrate binding site [chemical binding]; other site
596154006626	coenzyme A binding site [chemical binding]; other site
596154006627	catalytic triad [active]
596154006628	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
596154006629	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
596154006630	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
596154006631	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
596154006632	L-aspartate oxidase; Provisional; Region: PRK06175
596154006633	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
596154006634	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
596154006635	SdhC subunit interface [polypeptide binding]; other site
596154006636	proximal heme binding site [chemical binding]; other site
596154006637	cardiolipin binding site; other site
596154006638	Iron-sulfur protein interface; other site
596154006639	proximal quinone binding site [chemical binding]; other site
596154006640	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
596154006641	Iron-sulfur protein interface; other site
596154006642	proximal quinone binding site [chemical binding]; other site
596154006643	SdhD (CybS) interface [polypeptide binding]; other site
596154006644	proximal heme binding site [chemical binding]; other site
596154006645	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
596154006646	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154006647	DNA-binding site [nucleotide binding]; DNA binding site
596154006648	UTRA domain; Region: UTRA; pfam07702
596154006649	malate dehydrogenase; Provisional; Region: PRK05442
596154006650	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
596154006651	NAD(P) binding site [chemical binding]; other site
596154006652	dimer interface [polypeptide binding]; other site
596154006653	malate binding site [chemical binding]; other site
596154006654	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
596154006655	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154006656	S-adenosylmethionine binding site [chemical binding]; other site
596154006657	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
596154006658	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
596154006659	substrate binding site [chemical binding]; other site
596154006660	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
596154006661	substrate binding site [chemical binding]; other site
596154006662	ligand binding site [chemical binding]; other site
596154006663	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
596154006664	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154006665	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154006666	dimerization interface [polypeptide binding]; other site
596154006667	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154006668	active site
596154006669	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154006670	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154006671	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154006672	glutathione reductase; Validated; Region: PRK06116
596154006673	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
596154006674	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
596154006675	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
596154006676	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
596154006677	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
596154006678	catalytic loop [active]
596154006679	iron binding site [ion binding]; other site
596154006680	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
596154006681	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
596154006682	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
596154006683	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
596154006684	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
596154006685	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
596154006686	MoxR-like ATPases [General function prediction only]; Region: COG0714
596154006687	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
596154006688	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
596154006689	metal ion-dependent adhesion site (MIDAS); other site
596154006690	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
596154006691	putative hydrophobic ligand binding site [chemical binding]; other site
596154006692	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
596154006693	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
596154006694	XdhC Rossmann domain; Region: XdhC_C; pfam13478
596154006695	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
596154006696	metal-binding site
596154006697	bZIP transcription factor; Region: bZIP_1; cl02576
596154006698	hypothetical protein; Provisional; Region: PRK07233
596154006699	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
596154006700	hydroxyglutarate oxidase; Provisional; Region: PRK11728
596154006701	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
596154006702	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
596154006703	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
596154006704	Ligand binding site; other site
596154006705	Putative Catalytic site; other site
596154006706	DXD motif; other site
596154006707	putative protease; Provisional; Region: PRK15452
596154006708	Peptidase family U32; Region: Peptidase_U32; pfam01136
596154006709	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154006710	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154006711	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154006712	dimerization interface [polypeptide binding]; other site
596154006713	Transposase domain (DUF772); Region: DUF772; pfam05598
596154006714	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
596154006715	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
596154006716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154006717	active site
596154006718	phosphorylation site [posttranslational modification]
596154006719	intermolecular recognition site; other site
596154006720	dimerization interface [polypeptide binding]; other site
596154006721	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
596154006722	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
596154006723	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154006724	dimer interface [polypeptide binding]; other site
596154006725	phosphorylation site [posttranslational modification]
596154006726	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154006727	ATP binding site [chemical binding]; other site
596154006728	Mg2+ binding site [ion binding]; other site
596154006729	G-X-G motif; other site
596154006730	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
596154006731	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
596154006732	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
596154006733	Subunit I/III interface [polypeptide binding]; other site
596154006734	Subunit III/IV interface [polypeptide binding]; other site
596154006735	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
596154006736	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
596154006737	D-pathway; other site
596154006738	Putative ubiquinol binding site [chemical binding]; other site
596154006739	Low-spin heme (heme b) binding site [chemical binding]; other site
596154006740	Putative water exit pathway; other site
596154006741	Binuclear center (heme o3/CuB) [ion binding]; other site
596154006742	K-pathway; other site
596154006743	Putative proton exit pathway; other site
596154006744	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
596154006745	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
596154006746	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
596154006747	metabolite-proton symporter; Region: 2A0106; TIGR00883
596154006748	TolA protein; Region: tolA_full; TIGR02794
596154006749	TonB C terminal; Region: TonB_2; pfam13103
596154006750	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
596154006751	TolR protein; Region: tolR; TIGR02801
596154006752	TolQ protein; Region: tolQ; TIGR02796
596154006753	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
596154006754	active site
596154006755	aminotransferase; Validated; Region: PRK07337
596154006756	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
596154006757	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154006758	homodimer interface [polypeptide binding]; other site
596154006759	catalytic residue [active]
596154006760	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
596154006761	putative RNA binding site [nucleotide binding]; other site
596154006762	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
596154006763	homopentamer interface [polypeptide binding]; other site
596154006764	active site
596154006765	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
596154006766	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
596154006767	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
596154006768	dimerization interface [polypeptide binding]; other site
596154006769	active site
596154006770	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
596154006771	catalytic loop [active]
596154006772	iron binding site [ion binding]; other site
596154006773	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
596154006774	homodimer interface [polypeptide binding]; other site
596154006775	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
596154006776	NAD binding site [chemical binding]; other site
596154006777	active site
596154006778	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
596154006779	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
596154006780	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
596154006781	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
596154006782	homotrimer interaction site [polypeptide binding]; other site
596154006783	putative active site [active]
596154006784	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
596154006785	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
596154006786	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
596154006787	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
596154006788	catalytic loop [active]
596154006789	iron binding site [ion binding]; other site
596154006790	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
596154006791	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154006792	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154006793	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154006794	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154006795	dimerization interface [polypeptide binding]; other site
596154006796	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
596154006797	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
596154006798	GTP/Mg2+ binding site [chemical binding]; other site
596154006799	G4 box; other site
596154006800	G5 box; other site
596154006801	G1 box; other site
596154006802	Switch I region; other site
596154006803	G2 box; other site
596154006804	G3 box; other site
596154006805	Switch II region; other site
596154006806	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
596154006807	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
596154006808	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
596154006809	active site
596154006810	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
596154006811	enterobactin exporter EntS; Provisional; Region: PRK10489
596154006812	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154006813	putative substrate translocation pore; other site
596154006814	Staphylococcal nuclease homologues; Region: SNc; smart00318
596154006815	Catalytic site; other site
596154006816	Staphylococcal nuclease homologue; Region: SNase; pfam00565
596154006817	Predicted permeases [General function prediction only]; Region: RarD; COG2962
596154006818	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
596154006819	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
596154006820	pseudouridine synthase; Region: TIGR00093
596154006821	active site
596154006822	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
596154006823	Peptidase family M23; Region: Peptidase_M23; pfam01551
596154006824	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
596154006825	Aspartase; Region: Aspartase; cd01357
596154006826	active sites [active]
596154006827	tetramer interface [polypeptide binding]; other site
596154006828	META domain; Region: META; pfam03724
596154006829	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
596154006830	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
596154006831	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
596154006832	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
596154006833	active site
596154006834	HIGH motif; other site
596154006835	nucleotide binding site [chemical binding]; other site
596154006836	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
596154006837	active site
596154006838	KMSKS motif; other site
596154006839	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
596154006840	Dehydroquinase class II; Region: DHquinase_II; pfam01220
596154006841	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
596154006842	trimer interface [polypeptide binding]; other site
596154006843	active site
596154006844	dimer interface [polypeptide binding]; other site
596154006845	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
596154006846	hypothetical protein; Provisional; Region: PRK09256
596154006847	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
596154006848	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
596154006849	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
596154006850	putative active site [active]
596154006851	metal binding site [ion binding]; metal-binding site
596154006852	Predicted esterase [General function prediction only]; Region: COG0400
596154006853	putative hydrolase; Provisional; Region: PRK11460
596154006854	Protein of unknown function (DUF3014); Region: DUF3014; pfam11219
596154006855	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
596154006856	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
596154006857	putative DNA binding site [nucleotide binding]; other site
596154006858	putative Zn2+ binding site [ion binding]; other site
596154006859	AsnC family; Region: AsnC_trans_reg; pfam01037
596154006860	2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012
596154006861	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
596154006862	dimer interface [polypeptide binding]; other site
596154006863	TPP-binding site [chemical binding]; other site
596154006864	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
596154006865	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
596154006866	Amidase; Region: Amidase; cl11426
596154006867	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154006868	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154006869	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
596154006870	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
596154006871	dimerization interface [polypeptide binding]; other site
596154006872	substrate binding pocket [chemical binding]; other site
596154006873	Transcriptional regulators [Transcription]; Region: FadR; COG2186
596154006874	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154006875	DNA-binding site [nucleotide binding]; DNA binding site
596154006876	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
596154006877	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
596154006878	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154006879	putative substrate translocation pore; other site
596154006880	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
596154006881	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
596154006882	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
596154006883	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154006884	NAD(P) binding site [chemical binding]; other site
596154006885	active site
596154006886	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
596154006887	putative aldolase; Validated; Region: PRK08130
596154006888	intersubunit interface [polypeptide binding]; other site
596154006889	active site
596154006890	Zn2+ binding site [ion binding]; other site
596154006891	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
596154006892	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
596154006893	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
596154006894	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
596154006895	putative active site [active]
596154006896	putative metal binding site [ion binding]; other site
596154006897	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
596154006898	substrate binding site [chemical binding]; other site
596154006899	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
596154006900	substrate binding site [chemical binding]; other site
596154006901	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
596154006902	TPR repeat; Region: TPR_11; pfam13414
596154006903	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
596154006904	binding surface
596154006905	TPR motif; other site
596154006906	TPR repeat; Region: TPR_11; pfam13414
596154006907	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
596154006908	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
596154006909	active site
596154006910	HIGH motif; other site
596154006911	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
596154006912	KMSKS motif; other site
596154006913	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
596154006914	tRNA binding surface [nucleotide binding]; other site
596154006915	anticodon binding site; other site
596154006916	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
596154006917	endonuclease III; Region: ENDO3c; smart00478
596154006918	minor groove reading motif; other site
596154006919	helix-hairpin-helix signature motif; other site
596154006920	substrate binding pocket [chemical binding]; other site
596154006921	active site
596154006922	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
596154006923	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
596154006924	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
596154006925	Ligand Binding Site [chemical binding]; other site
596154006926	aspartate kinase; Reviewed; Region: PRK06635
596154006927	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
596154006928	putative nucleotide binding site [chemical binding]; other site
596154006929	putative catalytic residues [active]
596154006930	putative Mg ion binding site [ion binding]; other site
596154006931	putative aspartate binding site [chemical binding]; other site
596154006932	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
596154006933	putative allosteric regulatory site; other site
596154006934	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
596154006935	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
596154006936	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
596154006937	putative ion selectivity filter; other site
596154006938	putative pore gating glutamate residue; other site
596154006939	putative H+/Cl- coupling transport residue; other site
596154006940	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154006941	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154006942	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
596154006943	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
596154006944	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154006945	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
596154006946	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
596154006947	FtsX-like permease family; Region: FtsX; pfam02687
596154006948	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
596154006949	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
596154006950	Walker A/P-loop; other site
596154006951	ATP binding site [chemical binding]; other site
596154006952	Q-loop/lid; other site
596154006953	ABC transporter signature motif; other site
596154006954	Walker B; other site
596154006955	D-loop; other site
596154006956	H-loop/switch region; other site
596154006957	Transglycosylase SLT domain; Region: SLT_2; pfam13406
596154006958	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
596154006959	N-acetyl-D-glucosamine binding site [chemical binding]; other site
596154006960	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
596154006961	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
596154006962	exonuclease I; Provisional; Region: sbcB; PRK11779
596154006963	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
596154006964	active site
596154006965	catalytic site [active]
596154006966	substrate binding site [chemical binding]; other site
596154006967	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
596154006968	NAD-dependent deacetylase; Provisional; Region: PRK05333
596154006969	SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409
596154006970	NAD+ binding site [chemical binding]; other site
596154006971	substrate binding site [chemical binding]; other site
596154006972	Zn binding site [ion binding]; other site
596154006973	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
596154006974	Domain of unknown function DUF20; Region: UPF0118; pfam01594
596154006975	GAF domain; Region: GAF; pfam01590
596154006976	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
596154006977	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
596154006978	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
596154006979	active site
596154006980	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
596154006981	tetramer interface [polypeptide binding]; other site
596154006982	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154006983	catalytic residue [active]
596154006984	hypothetical protein; Provisional; Region: PRK12378
596154006985	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
596154006986	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
596154006987	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
596154006988	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
596154006989	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
596154006990	LrgB-like family; Region: LrgB; cl00596
596154006991	LrgA family; Region: LrgA; pfam03788
596154006992	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
596154006993	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154006994	DNA-binding site [nucleotide binding]; DNA binding site
596154006995	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
596154006996	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154006997	homodimer interface [polypeptide binding]; other site
596154006998	catalytic residue [active]
596154006999	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
596154007000	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
596154007001	C-terminal domain interface [polypeptide binding]; other site
596154007002	GSH binding site (G-site) [chemical binding]; other site
596154007003	dimer interface [polypeptide binding]; other site
596154007004	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
596154007005	N-terminal domain interface [polypeptide binding]; other site
596154007006	putative dimer interface [polypeptide binding]; other site
596154007007	active site
596154007008	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
596154007009	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
596154007010	hypothetical protein; Validated; Region: PRK00110
596154007011	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
596154007012	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
596154007013	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
596154007014	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
596154007015	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
596154007016	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
596154007017	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
596154007018	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
596154007019	Maf-like protein; Region: Maf; pfam02545
596154007020	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
596154007021	active site
596154007022	dimer interface [polypeptide binding]; other site
596154007023	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
596154007024	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
596154007025	ligand binding site [chemical binding]; other site
596154007026	flexible hinge region; other site
596154007027	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
596154007028	non-specific DNA interactions [nucleotide binding]; other site
596154007029	DNA binding site [nucleotide binding]
596154007030	sequence specific DNA binding site [nucleotide binding]; other site
596154007031	putative cAMP binding site [chemical binding]; other site
596154007032	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
596154007033	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
596154007034	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
596154007035	heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051
596154007036	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
596154007037	FeS/SAM binding site; other site
596154007038	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
596154007039	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
596154007040	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
596154007041	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
596154007042	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
596154007043	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
596154007044	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
596154007045	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
596154007046	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
596154007047	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
596154007048	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
596154007049	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
596154007050	active site
596154007051	SAM binding site [chemical binding]; other site
596154007052	homodimer interface [polypeptide binding]; other site
596154007053	ribonuclease G; Provisional; Region: PRK11712
596154007054	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
596154007055	homodimer interface [polypeptide binding]; other site
596154007056	oligonucleotide binding site [chemical binding]; other site
596154007057	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
596154007058	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154007059	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154007060	metal binding site [ion binding]; metal-binding site
596154007061	active site
596154007062	I-site; other site
596154007063	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154007064	dimerization interface [polypeptide binding]; other site
596154007065	methionine aminotransferase; Validated; Region: PRK09082
596154007066	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
596154007067	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154007068	homodimer interface [polypeptide binding]; other site
596154007069	catalytic residue [active]
596154007070	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682
596154007071	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154007072	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
596154007073	substrate binding site [chemical binding]; other site
596154007074	dimerization interface [polypeptide binding]; other site
596154007075	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
596154007076	putative active site [active]
596154007077	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
596154007078	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
596154007079	Predicted permeases [General function prediction only]; Region: COG0795
596154007080	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
596154007081	multifunctional aminopeptidase A; Provisional; Region: PRK00913
596154007082	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
596154007083	interface (dimer of trimers) [polypeptide binding]; other site
596154007084	Substrate-binding/catalytic site; other site
596154007085	Zn-binding sites [ion binding]; other site
596154007086	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
596154007087	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
596154007088	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
596154007089	dimerization interface [polypeptide binding]; other site
596154007090	ligand binding site [chemical binding]; other site
596154007091	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
596154007092	dimerization interface [polypeptide binding]; other site
596154007093	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
596154007094	NAD binding site [chemical binding]; other site
596154007095	ligand binding site [chemical binding]; other site
596154007096	catalytic site [active]
596154007097	Biofilm formation and stress response factor; Region: BsmA; pfam10014
596154007098	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
596154007099	Ligand Binding Site [chemical binding]; other site
596154007100	Hemerythrin; Region: Hemerythrin; cd12107
596154007101	Fe binding site [ion binding]; other site
596154007102	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154007103	beta-ketothiolase; Provisional; Region: PRK09051
596154007104	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
596154007105	dimer interface [polypeptide binding]; other site
596154007106	active site
596154007107	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154007108	short chain dehydrogenase; Provisional; Region: PRK07023
596154007109	NAD(P) binding site [chemical binding]; other site
596154007110	active site
596154007111	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
596154007112	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
596154007113	active site
596154007114	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
596154007115	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
596154007116	putative active site [active]
596154007117	heme pocket [chemical binding]; other site
596154007118	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154007119	dimer interface [polypeptide binding]; other site
596154007120	phosphorylation site [posttranslational modification]
596154007121	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154007122	ATP binding site [chemical binding]; other site
596154007123	Mg2+ binding site [ion binding]; other site
596154007124	G-X-G motif; other site
596154007125	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
596154007126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154007127	active site
596154007128	phosphorylation site [posttranslational modification]
596154007129	intermolecular recognition site; other site
596154007130	dimerization interface [polypeptide binding]; other site
596154007131	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
596154007132	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
596154007133	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
596154007134	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154007135	active site
596154007136	phosphorylation site [posttranslational modification]
596154007137	intermolecular recognition site; other site
596154007138	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
596154007139	DNA binding residues [nucleotide binding]
596154007140	dimerization interface [polypeptide binding]; other site
596154007141	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
596154007142	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154007143	ATP binding site [chemical binding]; other site
596154007144	Mg2+ binding site [ion binding]; other site
596154007145	G-X-G motif; other site
596154007146	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
596154007147	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
596154007148	catalytic residues [active]
596154007149	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
596154007150	Heavy-metal resistance; Region: Metal_resist; pfam13801
596154007151	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
596154007152	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
596154007153	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
596154007154	DNA binding residues [nucleotide binding]
596154007155	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
596154007156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154007157	S-adenosylmethionine binding site [chemical binding]; other site
596154007158	D-serine dehydratase; Provisional; Region: PRK02991
596154007159	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
596154007160	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
596154007161	catalytic residue [active]
596154007162	Uncharacterized conserved protein [Function unknown]; Region: COG1739
596154007163	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
596154007164	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
596154007165	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
596154007166	hypothetical protein; Provisional; Region: PRK01254
596154007167	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
596154007168	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
596154007169	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
596154007170	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
596154007171	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
596154007172	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154007173	homodimer interface [polypeptide binding]; other site
596154007174	catalytic residue [active]
596154007175	excinuclease ABC subunit B; Provisional; Region: PRK05298
596154007176	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
596154007177	ATP binding site [chemical binding]; other site
596154007178	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
596154007179	nucleotide binding region [chemical binding]; other site
596154007180	ATP-binding site [chemical binding]; other site
596154007181	Ultra-violet resistance protein B; Region: UvrB; pfam12344
596154007182	UvrB/uvrC motif; Region: UVR; pfam02151
596154007183	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
596154007184	Rrf2 family protein; Region: rrf2_super; TIGR00738
596154007185	cysteine desulfurase; Provisional; Region: PRK14012
596154007186	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
596154007187	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
596154007188	catalytic residue [active]
596154007189	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
596154007190	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
596154007191	trimerization site [polypeptide binding]; other site
596154007192	active site
596154007193	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
596154007194	co-chaperone HscB; Provisional; Region: hscB; PRK03578
596154007195	DnaJ domain; Region: DnaJ; pfam00226
596154007196	HSP70 interaction site [polypeptide binding]; other site
596154007197	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
596154007198	chaperone protein HscA; Provisional; Region: hscA; PRK05183
596154007199	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
596154007200	nucleotide binding site [chemical binding]; other site
596154007201	putative NEF/HSP70 interaction site [polypeptide binding]; other site
596154007202	SBD interface [polypeptide binding]; other site
596154007203	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
596154007204	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
596154007205	catalytic loop [active]
596154007206	iron binding site [ion binding]; other site
596154007207	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
596154007208	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
596154007209	active site
596154007210	catalytic site [active]
596154007211	substrate binding site [chemical binding]; other site
596154007212	Predicted dehydrogenase [General function prediction only]; Region: COG0579
596154007213	hydroxyglutarate oxidase; Provisional; Region: PRK11728
596154007214	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
596154007215	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
596154007216	quinone interaction residues [chemical binding]; other site
596154007217	active site
596154007218	catalytic residues [active]
596154007219	FMN binding site [chemical binding]; other site
596154007220	substrate binding site [chemical binding]; other site
596154007221	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
596154007222	tetramer (dimer of dimers) interface [polypeptide binding]; other site
596154007223	active site
596154007224	dimer interface [polypeptide binding]; other site
596154007225	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
596154007226	catalytic residues [active]
596154007227	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
596154007228	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
596154007229	active site
596154007230	Zn binding site [ion binding]; other site
596154007231	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
596154007232	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
596154007233	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
596154007234	homodimer interface [polypeptide binding]; other site
596154007235	NADP binding site [chemical binding]; other site
596154007236	substrate binding site [chemical binding]; other site
596154007237	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
596154007238	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154007239	active site
596154007240	phosphorylation site [posttranslational modification]
596154007241	intermolecular recognition site; other site
596154007242	dimerization interface [polypeptide binding]; other site
596154007243	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
596154007244	DNA binding residues [nucleotide binding]
596154007245	dimerization interface [polypeptide binding]; other site
596154007246	PAS domain S-box; Region: sensory_box; TIGR00229
596154007247	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154007248	putative active site [active]
596154007249	heme pocket [chemical binding]; other site
596154007250	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154007251	dimer interface [polypeptide binding]; other site
596154007252	phosphorylation site [posttranslational modification]
596154007253	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154007254	ATP binding site [chemical binding]; other site
596154007255	Mg2+ binding site [ion binding]; other site
596154007256	G-X-G motif; other site
596154007257	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
596154007258	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
596154007259	dimer interface [polypeptide binding]; other site
596154007260	TPP-binding site [chemical binding]; other site
596154007261	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
596154007262	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
596154007263	E3 interaction surface; other site
596154007264	lipoyl attachment site [posttranslational modification]; other site
596154007265	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
596154007266	E3 interaction surface; other site
596154007267	lipoyl attachment site [posttranslational modification]; other site
596154007268	e3 binding domain; Region: E3_binding; pfam02817
596154007269	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
596154007270	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
596154007271	E3 interaction surface; other site
596154007272	lipoyl attachment site [posttranslational modification]; other site
596154007273	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
596154007274	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
596154007275	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
596154007276	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
596154007277	Predicted membrane protein (DUF2214); Region: DUF2214; cl01427
596154007278	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154007279	Fic family protein [Function unknown]; Region: COG3177
596154007280	Fic/DOC family; Region: Fic; pfam02661
596154007281	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154007282	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154007283	dimerization interface [polypeptide binding]; other site
596154007284	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
596154007285	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
596154007286	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
596154007287	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
596154007288	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
596154007289	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
596154007290	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
596154007291	Transposase; Region: HTH_Tnp_1; pfam01527
596154007292	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154007293	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
596154007294	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
596154007295	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
596154007296	EVE domain; Region: EVE; cl00728
596154007297	Transglycosylase associated protein; Region: Transgly_assoc; pfam04226
596154007298	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
596154007299	NlpC/P60 family; Region: NLPC_P60; pfam00877
596154007300	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
596154007301	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154007302	putative substrate translocation pore; other site
596154007303	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
596154007304	PAS domain S-box; Region: sensory_box; TIGR00229
596154007305	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154007306	putative active site [active]
596154007307	heme pocket [chemical binding]; other site
596154007308	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154007309	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154007310	metal binding site [ion binding]; metal-binding site
596154007311	active site
596154007312	I-site; other site
596154007313	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
596154007314	hypothetical protein; Provisional; Region: PRK02237
596154007315	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
596154007316	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
596154007317	Walker A/P-loop; other site
596154007318	ATP binding site [chemical binding]; other site
596154007319	Q-loop/lid; other site
596154007320	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
596154007321	Q-loop/lid; other site
596154007322	ABC transporter signature motif; other site
596154007323	Walker B; other site
596154007324	D-loop; other site
596154007325	H-loop/switch region; other site
596154007326	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
596154007327	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
596154007328	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
596154007329	nucleotide binding pocket [chemical binding]; other site
596154007330	K-X-D-G motif; other site
596154007331	catalytic site [active]
596154007332	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
596154007333	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
596154007334	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
596154007335	Dimer interface [polypeptide binding]; other site
596154007336	BRCT sequence motif; other site
596154007337	hypothetical protein; Provisional; Region: PRK10279
596154007338	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
596154007339	nucleophile elbow; other site
596154007340	Transglycosylase; Region: Transgly; pfam00912
596154007341	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
596154007342	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154007343	Major Facilitator Superfamily; Region: MFS_1; pfam07690
596154007344	putative substrate translocation pore; other site
596154007345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154007346	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
596154007347	nudix motif; other site
596154007348	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
596154007349	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
596154007350	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
596154007351	maleylacetoacetate isomerase; Region: maiA; TIGR01262
596154007352	C-terminal domain interface [polypeptide binding]; other site
596154007353	GSH binding site (G-site) [chemical binding]; other site
596154007354	putative dimer interface [polypeptide binding]; other site
596154007355	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
596154007356	dimer interface [polypeptide binding]; other site
596154007357	N-terminal domain interface [polypeptide binding]; other site
596154007358	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
596154007359	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
596154007360	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
596154007361	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
596154007362	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
596154007363	putative acyltransferase; Provisional; Region: PRK05790
596154007364	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
596154007365	dimer interface [polypeptide binding]; other site
596154007366	active site
596154007367	acetyacetyl-CoA reductase; Provisional; Region: PRK12938
596154007368	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
596154007369	NAD(P) binding site [chemical binding]; other site
596154007370	homotetramer interface [polypeptide binding]; other site
596154007371	homodimer interface [polypeptide binding]; other site
596154007372	active site
596154007373	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
596154007374	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
596154007375	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
596154007376	ABC transporter; Region: ABC_tran_2; pfam12848
596154007377	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
596154007378	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154007379	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154007380	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
596154007381	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
596154007382	active site
596154007383	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
596154007384	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154007385	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
596154007386	acyl-activating enzyme (AAE) consensus motif; other site
596154007387	acyl-activating enzyme (AAE) consensus motif; other site
596154007388	putative AMP binding site [chemical binding]; other site
596154007389	putative active site [active]
596154007390	putative CoA binding site [chemical binding]; other site
596154007391	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154007392	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154007393	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
596154007394	dimerization interface [polypeptide binding]; other site
596154007395	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
596154007396	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154007397	S-adenosylmethionine binding site [chemical binding]; other site
596154007398	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
596154007399	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
596154007400	metal binding site [ion binding]; metal-binding site
596154007401	dimer interface [polypeptide binding]; other site
596154007402	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
596154007403	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
596154007404	Walker A motif; other site
596154007405	ATP binding site [chemical binding]; other site
596154007406	Walker B motif; other site
596154007407	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
596154007408	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
596154007409	active site
596154007410	substrate binding site [chemical binding]; other site
596154007411	trimer interface [polypeptide binding]; other site
596154007412	CoA binding site [chemical binding]; other site
596154007413	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
596154007414	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
596154007415	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154007416	homodimer interface [polypeptide binding]; other site
596154007417	catalytic residue [active]
596154007418	ferredoxin; Provisional; Region: PRK08764
596154007419	Putative Fe-S cluster; Region: FeS; cl17515
596154007420	4Fe-4S binding domain; Region: Fer4; pfam00037
596154007421	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
596154007422	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
596154007423	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
596154007424	synthetase active site [active]
596154007425	NTP binding site [chemical binding]; other site
596154007426	metal binding site [ion binding]; metal-binding site
596154007427	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
596154007428	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
596154007429	FMN binding site [chemical binding]; other site
596154007430	active site
596154007431	catalytic residues [active]
596154007432	substrate binding site [chemical binding]; other site
596154007433	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
596154007434	putative active site [active]
596154007435	putative catalytic site [active]
596154007436	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154007437	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154007438	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
596154007439	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
596154007440	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154007441	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
596154007442	acyl-activating enzyme (AAE) consensus motif; other site
596154007443	acyl-activating enzyme (AAE) consensus motif; other site
596154007444	putative AMP binding site [chemical binding]; other site
596154007445	putative active site [active]
596154007446	putative CoA binding site [chemical binding]; other site
596154007447	Transcriptional regulators [Transcription]; Region: GntR; COG1802
596154007448	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154007449	DNA-binding site [nucleotide binding]; DNA binding site
596154007450	FCD domain; Region: FCD; pfam07729
596154007451	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
596154007452	active site
596154007453	catalytic residues [active]
596154007454	metal binding site [ion binding]; metal-binding site
596154007455	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154007456	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154007457	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154007458	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
596154007459	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154007460	non-specific DNA binding site [nucleotide binding]; other site
596154007461	salt bridge; other site
596154007462	sequence-specific DNA binding site [nucleotide binding]; other site
596154007463	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
596154007464	Domain of unknown function (DUF955); Region: DUF955; pfam06114
596154007465	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
596154007466	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
596154007467	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
596154007468	active site
596154007469	substrate binding site [chemical binding]; other site
596154007470	coenzyme B12 binding site [chemical binding]; other site
596154007471	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
596154007472	B12 binding site [chemical binding]; other site
596154007473	cobalt ligand [ion binding]; other site
596154007474	membrane ATPase/protein kinase; Provisional; Region: PRK09435
596154007475	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
596154007476	Walker A; other site
596154007477	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
596154007478	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
596154007479	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
596154007480	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
596154007481	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
596154007482	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
596154007483	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
596154007484	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
596154007485	carboxyltransferase (CT) interaction site; other site
596154007486	biotinylation site [posttranslational modification]; other site
596154007487	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
596154007488	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
596154007489	dimer interface [polypeptide binding]; other site
596154007490	substrate binding site [chemical binding]; other site
596154007491	metal binding site [ion binding]; metal-binding site
596154007492	biotin synthase; Region: bioB; TIGR00433
596154007493	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
596154007494	FeS/SAM binding site; other site
596154007495	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
596154007496	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154007497	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
596154007498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154007499	active site
596154007500	phosphorylation site [posttranslational modification]
596154007501	intermolecular recognition site; other site
596154007502	dimerization interface [polypeptide binding]; other site
596154007503	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
596154007504	DNA binding site [nucleotide binding]
596154007505	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
596154007506	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
596154007507	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154007508	dimer interface [polypeptide binding]; other site
596154007509	phosphorylation site [posttranslational modification]
596154007510	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154007511	ATP binding site [chemical binding]; other site
596154007512	Mg2+ binding site [ion binding]; other site
596154007513	G-X-G motif; other site
596154007514	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154007515	OsmC-like protein; Region: OsmC; pfam02566
596154007516	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
596154007517	active site residue [active]
596154007518	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
596154007519	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
596154007520	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
596154007521	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
596154007522	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
596154007523	Outer membrane efflux protein; Region: OEP; pfam02321
596154007524	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
596154007525	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
596154007526	Protein export membrane protein; Region: SecD_SecF; cl14618
596154007527	Protein export membrane protein; Region: SecD_SecF; cl14618
596154007528	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
596154007529	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
596154007530	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154007531	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
596154007532	dimerization interface [polypeptide binding]; other site
596154007533	putative DNA binding site [nucleotide binding]; other site
596154007534	putative Zn2+ binding site [ion binding]; other site
596154007535	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
596154007536	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
596154007537	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154007538	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154007539	Transcriptional regulators [Transcription]; Region: PurR; COG1609
596154007540	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
596154007541	DNA binding site [nucleotide binding]
596154007542	domain linker motif; other site
596154007543	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
596154007544	putative dimerization interface [polypeptide binding]; other site
596154007545	putative ligand binding site [chemical binding]; other site
596154007546	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154007547	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
596154007548	NAD(P) binding site [chemical binding]; other site
596154007549	active site
596154007550	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
596154007551	histidinol dehydrogenase; Region: hisD; TIGR00069
596154007552	NAD binding site [chemical binding]; other site
596154007553	dimerization interface [polypeptide binding]; other site
596154007554	product binding site; other site
596154007555	substrate binding site [chemical binding]; other site
596154007556	zinc binding site [ion binding]; other site
596154007557	catalytic residues [active]
596154007558	Methyltransferase domain; Region: Methyltransf_23; pfam13489
596154007559	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154007560	S-adenosylmethionine binding site [chemical binding]; other site
596154007561	DTW domain; Region: DTW; cl01221
596154007562	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
596154007563	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
596154007564	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
596154007565	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
596154007566	Sulfatase; Region: Sulfatase; pfam00884
596154007567	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
596154007568	active site
596154007569	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
596154007570	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154007571	active site
596154007572	phosphorylation site [posttranslational modification]
596154007573	intermolecular recognition site; other site
596154007574	dimerization interface [polypeptide binding]; other site
596154007575	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
596154007576	DNA binding site [nucleotide binding]
596154007577	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
596154007578	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154007579	ATP binding site [chemical binding]; other site
596154007580	Mg2+ binding site [ion binding]; other site
596154007581	G-X-G motif; other site
596154007582	enoyl-CoA hydratase; Provisional; Region: PRK06494
596154007583	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154007584	substrate binding site [chemical binding]; other site
596154007585	oxyanion hole (OAH) forming residues; other site
596154007586	trimer interface [polypeptide binding]; other site
596154007587	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154007588	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
596154007589	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
596154007590	NAD(P) binding site [chemical binding]; other site
596154007591	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154007592	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154007593	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154007594	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154007595	active site
596154007596	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154007597	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154007598	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154007599	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154007600	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
596154007601	hydroxyglutarate oxidase; Provisional; Region: PRK11728
596154007602	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
596154007603	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
596154007604	zinc binding site [ion binding]; other site
596154007605	putative ligand binding site [chemical binding]; other site
596154007606	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154007607	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
596154007608	TM-ABC transporter signature motif; other site
596154007609	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
596154007610	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
596154007611	Walker A/P-loop; other site
596154007612	ATP binding site [chemical binding]; other site
596154007613	Q-loop/lid; other site
596154007614	ABC transporter signature motif; other site
596154007615	Walker B; other site
596154007616	D-loop; other site
596154007617	H-loop/switch region; other site
596154007618	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
596154007619	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154007620	Walker A motif; other site
596154007621	ATP binding site [chemical binding]; other site
596154007622	Walker B motif; other site
596154007623	arginine finger; other site
596154007624	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
596154007625	PGAP1-like protein; Region: PGAP1; pfam07819
596154007626	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
596154007627	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
596154007628	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
596154007629	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
596154007630	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
596154007631	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
596154007632	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
596154007633	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
596154007634	E3 interaction surface; other site
596154007635	lipoyl attachment site [posttranslational modification]; other site
596154007636	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
596154007637	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
596154007638	alpha subunit interface [polypeptide binding]; other site
596154007639	TPP binding site [chemical binding]; other site
596154007640	heterodimer interface [polypeptide binding]; other site
596154007641	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
596154007642	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
596154007643	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
596154007644	tetramer interface [polypeptide binding]; other site
596154007645	TPP-binding site [chemical binding]; other site
596154007646	heterodimer interface [polypeptide binding]; other site
596154007647	phosphorylation loop region [posttranslational modification]
596154007648	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
596154007649	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
596154007650	putative DNA binding site [nucleotide binding]; other site
596154007651	putative Zn2+ binding site [ion binding]; other site
596154007652	AsnC family; Region: AsnC_trans_reg; pfam01037
596154007653	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
596154007654	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
596154007655	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
596154007656	DctM-like transporters; Region: DctM; pfam06808
596154007657	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
596154007658	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
596154007659	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
596154007660	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
596154007661	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
596154007662	lipoyl attachment site [posttranslational modification]; other site
596154007663	glycine dehydrogenase; Provisional; Region: PRK05367
596154007664	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
596154007665	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
596154007666	catalytic residue [active]
596154007667	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
596154007668	tetramer interface [polypeptide binding]; other site
596154007669	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154007670	catalytic residue [active]
596154007671	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
596154007672	putative metal binding site [ion binding]; other site
596154007673	putative homodimer interface [polypeptide binding]; other site
596154007674	putative homotetramer interface [polypeptide binding]; other site
596154007675	putative homodimer-homodimer interface [polypeptide binding]; other site
596154007676	putative allosteric switch controlling residues; other site
596154007677	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
596154007678	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
596154007679	substrate binding site [chemical binding]; other site
596154007680	catalytic Zn binding site [ion binding]; other site
596154007681	NAD binding site [chemical binding]; other site
596154007682	structural Zn binding site [ion binding]; other site
596154007683	dimer interface [polypeptide binding]; other site
596154007684	S-formylglutathione hydrolase; Region: PLN02442
596154007685	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
596154007686	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154007687	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154007688	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
596154007689	dimerization interface [polypeptide binding]; other site
596154007690	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
596154007691	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
596154007692	FeS/SAM binding site; other site
596154007693	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
596154007694	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
596154007695	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
596154007696	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
596154007697	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
596154007698	FMN binding site [chemical binding]; other site
596154007699	substrate binding site [chemical binding]; other site
596154007700	putative catalytic residue [active]
596154007701	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
596154007702	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
596154007703	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154007704	active site
596154007705	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
596154007706	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
596154007707	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
596154007708	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
596154007709	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
596154007710	Ligand binding site [chemical binding]; other site
596154007711	Electron transfer flavoprotein domain; Region: ETF; pfam01012
596154007712	enoyl-CoA hydratase; Validated; Region: PRK08139
596154007713	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154007714	substrate binding site [chemical binding]; other site
596154007715	oxyanion hole (OAH) forming residues; other site
596154007716	trimer interface [polypeptide binding]; other site
596154007717	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
596154007718	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
596154007719	putative active site [active]
596154007720	Zn binding site [ion binding]; other site
596154007721	MoxR-like ATPases [General function prediction only]; Region: COG0714
596154007722	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154007723	Walker A motif; other site
596154007724	ATP binding site [chemical binding]; other site
596154007725	Walker B motif; other site
596154007726	arginine finger; other site
596154007727	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
596154007728	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
596154007729	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
596154007730	Transglycosylase SLT domain; Region: SLT_2; pfam13406
596154007731	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
596154007732	N-acetyl-D-glucosamine binding site [chemical binding]; other site
596154007733	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
596154007734	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
596154007735	PYR/PP interface [polypeptide binding]; other site
596154007736	dimer interface [polypeptide binding]; other site
596154007737	TPP binding site [chemical binding]; other site
596154007738	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
596154007739	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
596154007740	TPP-binding site [chemical binding]; other site
596154007741	dimer interface [polypeptide binding]; other site
596154007742	DctM-like transporters; Region: DctM; pfam06808
596154007743	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
596154007744	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
596154007745	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
596154007746	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
596154007747	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
596154007748	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154007749	NAD(P) binding site [chemical binding]; other site
596154007750	active site
596154007751	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
596154007752	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154007753	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
596154007754	dimerization interface [polypeptide binding]; other site
596154007755	substrate binding pocket [chemical binding]; other site
596154007756	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
596154007757	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
596154007758	TPP-binding site [chemical binding]; other site
596154007759	dimer interface [polypeptide binding]; other site
596154007760	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
596154007761	PYR/PP interface [polypeptide binding]; other site
596154007762	dimer interface [polypeptide binding]; other site
596154007763	TPP binding site [chemical binding]; other site
596154007764	glycerate dehydrogenase; Provisional; Region: PRK06932
596154007765	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
596154007766	putative ligand binding site [chemical binding]; other site
596154007767	putative NAD binding site [chemical binding]; other site
596154007768	catalytic site [active]
596154007769	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
596154007770	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154007771	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
596154007772	putative dimerization interface [polypeptide binding]; other site
596154007773	Predicted membrane protein [Function unknown]; Region: COG2855
596154007774	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154007775	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
596154007776	putative ligand binding site [chemical binding]; other site
596154007777	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
596154007778	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
596154007779	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
596154007780	FtsX-like permease family; Region: FtsX; pfam02687
596154007781	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
596154007782	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
596154007783	Walker A/P-loop; other site
596154007784	ATP binding site [chemical binding]; other site
596154007785	Q-loop/lid; other site
596154007786	ABC transporter signature motif; other site
596154007787	Walker B; other site
596154007788	D-loop; other site
596154007789	H-loop/switch region; other site
596154007790	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
596154007791	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154007792	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
596154007793	UGMP family protein; Validated; Region: PRK09604
596154007794	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
596154007795	FOG: CBS domain [General function prediction only]; Region: COG0517
596154007796	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
596154007797	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
596154007798	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
596154007799	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154007800	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
596154007801	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
596154007802	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
596154007803	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
596154007804	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
596154007805	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
596154007806	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
596154007807	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
596154007808	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
596154007809	[2Fe-2S] cluster binding site [ion binding]; other site
596154007810	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
596154007811	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
596154007812	[4Fe-4S] binding site [ion binding]; other site
596154007813	molybdopterin cofactor binding site; other site
596154007814	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
596154007815	molybdopterin cofactor binding site; other site
596154007816	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
596154007817	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
596154007818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154007819	putative substrate translocation pore; other site
596154007820	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
596154007821	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
596154007822	glycosyl transferase family protein; Provisional; Region: PRK08136
596154007823	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
596154007824	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
596154007825	active site
596154007826	SAM binding site [chemical binding]; other site
596154007827	homodimer interface [polypeptide binding]; other site
596154007828	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
596154007829	HI0933-like protein; Region: HI0933_like; pfam03486
596154007830	NnrS protein; Region: NnrS; pfam05940
596154007831	Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719
596154007832	Domain of unknown function DUF59; Region: DUF59; cl00941
596154007833	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
596154007834	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
596154007835	trimerization site [polypeptide binding]; other site
596154007836	active site
596154007837	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
596154007838	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
596154007839	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
596154007840	catalytic residue [active]
596154007841	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
596154007842	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
596154007843	FeS assembly ATPase SufC; Region: sufC; TIGR01978
596154007844	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154007845	Walker A/P-loop; other site
596154007846	ATP binding site [chemical binding]; other site
596154007847	Q-loop/lid; other site
596154007848	ABC transporter signature motif; other site
596154007849	Walker B; other site
596154007850	D-loop; other site
596154007851	H-loop/switch region; other site
596154007852	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
596154007853	putative ABC transporter; Region: ycf24; CHL00085
596154007854	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
596154007855	Yqey-like protein; Region: YqeY; pfam09424
596154007856	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
596154007857	Zn2+ binding site [ion binding]; other site
596154007858	Mg2+ binding site [ion binding]; other site
596154007859	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
596154007860	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
596154007861	PAS domain; Region: PAS_9; pfam13426
596154007862	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154007863	putative active site [active]
596154007864	heme pocket [chemical binding]; other site
596154007865	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
596154007866	DNA binding residues [nucleotide binding]
596154007867	dimerization interface [polypeptide binding]; other site
596154007868	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
596154007869	N-acetylglutamate synthase; Validated; Region: PRK05279
596154007870	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
596154007871	putative feedback inhibition sensing region; other site
596154007872	putative nucleotide binding site [chemical binding]; other site
596154007873	putative substrate binding site [chemical binding]; other site
596154007874	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
596154007875	Coenzyme A binding pocket [chemical binding]; other site
596154007876	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
596154007877	homotrimer interaction site [polypeptide binding]; other site
596154007878	putative active site [active]
596154007879	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
596154007880	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
596154007881	hydroxyglutarate oxidase; Provisional; Region: PRK11728
596154007882	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
596154007883	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
596154007884	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
596154007885	ligand binding site [chemical binding]; other site
596154007886	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
596154007887	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154007888	TM-ABC transporter signature motif; other site
596154007889	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
596154007890	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
596154007891	TM-ABC transporter signature motif; other site
596154007892	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
596154007893	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
596154007894	Walker A/P-loop; other site
596154007895	ATP binding site [chemical binding]; other site
596154007896	Q-loop/lid; other site
596154007897	ABC transporter signature motif; other site
596154007898	Walker B; other site
596154007899	D-loop; other site
596154007900	H-loop/switch region; other site
596154007901	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
596154007902	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
596154007903	Walker A/P-loop; other site
596154007904	ATP binding site [chemical binding]; other site
596154007905	Q-loop/lid; other site
596154007906	ABC transporter signature motif; other site
596154007907	Walker B; other site
596154007908	D-loop; other site
596154007909	H-loop/switch region; other site
596154007910	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
596154007911	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
596154007912	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
596154007913	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
596154007914	dimer interface [polypeptide binding]; other site
596154007915	active site
596154007916	catalytic residue [active]
596154007917	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
596154007918	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
596154007919	dimer interface [polypeptide binding]; other site
596154007920	PYR/PP interface [polypeptide binding]; other site
596154007921	TPP binding site [chemical binding]; other site
596154007922	substrate binding site [chemical binding]; other site
596154007923	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
596154007924	TPP-binding site [chemical binding]; other site
596154007925	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
596154007926	Transcriptional regulators [Transcription]; Region: FadR; COG2186
596154007927	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154007928	DNA-binding site [nucleotide binding]; DNA binding site
596154007929	FCD domain; Region: FCD; pfam07729
596154007930	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
596154007931	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
596154007932	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
596154007933	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
596154007934	Zn2+ binding site [ion binding]; other site
596154007935	Mg2+ binding site [ion binding]; other site
596154007936	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
596154007937	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
596154007938	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
596154007939	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
596154007940	Walker A/P-loop; other site
596154007941	ATP binding site [chemical binding]; other site
596154007942	Q-loop/lid; other site
596154007943	ABC transporter signature motif; other site
596154007944	Walker B; other site
596154007945	D-loop; other site
596154007946	H-loop/switch region; other site
596154007947	TOBE-like domain; Region: TOBE_3; pfam12857
596154007948	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154007949	dimer interface [polypeptide binding]; other site
596154007950	conserved gate region; other site
596154007951	putative PBP binding loops; other site
596154007952	ABC-ATPase subunit interface; other site
596154007953	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
596154007954	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154007955	dimer interface [polypeptide binding]; other site
596154007956	conserved gate region; other site
596154007957	putative PBP binding loops; other site
596154007958	ABC-ATPase subunit interface; other site
596154007959	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
596154007960	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
596154007961	Serine hydrolase; Region: Ser_hydrolase; pfam06821
596154007962	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
596154007963	LysR family transcriptional regulator; Provisional; Region: PRK14997
596154007964	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
596154007965	putative effector binding pocket; other site
596154007966	putative dimerization interface [polypeptide binding]; other site
596154007967	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
596154007968	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
596154007969	Predicted flavoprotein [General function prediction only]; Region: COG0431
596154007970	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
596154007971	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
596154007972	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
596154007973	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154007974	dimer interface [polypeptide binding]; other site
596154007975	conserved gate region; other site
596154007976	ABC-ATPase subunit interface; other site
596154007977	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
596154007978	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
596154007979	Walker A/P-loop; other site
596154007980	ATP binding site [chemical binding]; other site
596154007981	Q-loop/lid; other site
596154007982	ABC transporter signature motif; other site
596154007983	Walker B; other site
596154007984	D-loop; other site
596154007985	H-loop/switch region; other site
596154007986	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
596154007987	MAPEG family; Region: MAPEG; cl09190
596154007988	recombination protein RecR; Reviewed; Region: recR; PRK00076
596154007989	RecR protein; Region: RecR; pfam02132
596154007990	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
596154007991	putative active site [active]
596154007992	putative metal-binding site [ion binding]; other site
596154007993	tetramer interface [polypeptide binding]; other site
596154007994	hypothetical protein; Validated; Region: PRK00153
596154007995	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
596154007996	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154007997	Walker A motif; other site
596154007998	ATP binding site [chemical binding]; other site
596154007999	Walker B motif; other site
596154008000	arginine finger; other site
596154008001	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
596154008002	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
596154008003	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
596154008004	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
596154008005	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
596154008006	putative molybdenum utilization protein ModD; Region: modD; TIGR01334
596154008007	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
596154008008	active site
596154008009	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
596154008010	putative PBP binding loops; other site
596154008011	ABC-ATPase subunit interface; other site
596154008012	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
596154008013	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
596154008014	Domain of unknown function (DUF4213); Region: DUF4213; pfam13938
596154008015	Uncharacterized conserved protein [Function unknown]; Region: COG2014
596154008016	Domain of unknown function (DUF364); Region: DUF364; pfam04016
596154008017	Methyltransferase domain; Region: Methyltransf_18; pfam12847
596154008018	S-adenosylmethionine binding site [chemical binding]; other site
596154008019	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
596154008020	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
596154008021	Walker A/P-loop; other site
596154008022	ATP binding site [chemical binding]; other site
596154008023	Q-loop/lid; other site
596154008024	ABC transporter signature motif; other site
596154008025	Walker B; other site
596154008026	D-loop; other site
596154008027	H-loop/switch region; other site
596154008028	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
596154008029	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
596154008030	putative PBP binding regions; other site
596154008031	ABC-ATPase subunit  interface; other site
596154008032	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
596154008033	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
596154008034	intersubunit interface [polypeptide binding]; other site
596154008035	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
596154008036	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
596154008037	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
596154008038	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
596154008039	N-terminal plug; other site
596154008040	ligand-binding site [chemical binding]; other site
596154008041	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
596154008042	Pirin-related protein [General function prediction only]; Region: COG1741
596154008043	Pirin; Region: Pirin; pfam02678
596154008044	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
596154008045	Pirin-related protein [General function prediction only]; Region: COG1741
596154008046	Pirin; Region: Pirin; pfam02678
596154008047	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
596154008048	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
596154008049	AAA domain; Region: AAA_30; pfam13604
596154008050	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
596154008051	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
596154008052	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
596154008053	catalytic residues [active]
596154008054	transcription termination factor Rho; Provisional; Region: rho; PRK09376
596154008055	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
596154008056	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
596154008057	RNA binding site [nucleotide binding]; other site
596154008058	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
596154008059	multimer interface [polypeptide binding]; other site
596154008060	Walker A motif; other site
596154008061	ATP binding site [chemical binding]; other site
596154008062	Walker B motif; other site
596154008063	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
596154008064	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
596154008065	putative efflux protein, MATE family; Region: matE; TIGR00797
596154008066	cation binding site [ion binding]; other site
596154008067	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
596154008068	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154008069	putative active site [active]
596154008070	heme pocket [chemical binding]; other site
596154008071	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154008072	dimer interface [polypeptide binding]; other site
596154008073	phosphorylation site [posttranslational modification]
596154008074	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154008075	ATP binding site [chemical binding]; other site
596154008076	Mg2+ binding site [ion binding]; other site
596154008077	G-X-G motif; other site
596154008078	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
596154008079	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154008080	active site
596154008081	phosphorylation site [posttranslational modification]
596154008082	intermolecular recognition site; other site
596154008083	dimerization interface [polypeptide binding]; other site
596154008084	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
596154008085	DNA binding site [nucleotide binding]
596154008086	transcriptional regulator PhoU; Provisional; Region: PRK11115
596154008087	PhoU domain; Region: PhoU; pfam01895
596154008088	PhoU domain; Region: PhoU; pfam01895
596154008089	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
596154008090	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
596154008091	Walker A/P-loop; other site
596154008092	ATP binding site [chemical binding]; other site
596154008093	Q-loop/lid; other site
596154008094	ABC transporter signature motif; other site
596154008095	Walker B; other site
596154008096	D-loop; other site
596154008097	H-loop/switch region; other site
596154008098	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
596154008099	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154008100	dimer interface [polypeptide binding]; other site
596154008101	conserved gate region; other site
596154008102	putative PBP binding loops; other site
596154008103	ABC-ATPase subunit interface; other site
596154008104	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154008105	dimer interface [polypeptide binding]; other site
596154008106	conserved gate region; other site
596154008107	putative PBP binding loops; other site
596154008108	ABC-ATPase subunit interface; other site
596154008109	PBP superfamily domain; Region: PBP_like_2; cl17296
596154008110	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
596154008111	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
596154008112	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
596154008113	catalytic core [active]
596154008114	polyphosphate kinase; Provisional; Region: PRK05443
596154008115	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
596154008116	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
596154008117	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
596154008118	putative domain interface [polypeptide binding]; other site
596154008119	putative active site [active]
596154008120	catalytic site [active]
596154008121	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
596154008122	putative active site [active]
596154008123	catalytic site [active]
596154008124	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
596154008125	PAS domain S-box; Region: sensory_box; TIGR00229
596154008126	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154008127	putative active site [active]
596154008128	heme pocket [chemical binding]; other site
596154008129	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154008130	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154008131	metal binding site [ion binding]; metal-binding site
596154008132	active site
596154008133	I-site; other site
596154008134	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
596154008135	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
596154008136	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
596154008137	active site
596154008138	substrate binding site [chemical binding]; other site
596154008139	metal binding site [ion binding]; metal-binding site
596154008140	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
596154008141	dihydropteroate synthase; Region: DHPS; TIGR01496
596154008142	substrate binding pocket [chemical binding]; other site
596154008143	dimer interface [polypeptide binding]; other site
596154008144	inhibitor binding site; inhibition site
596154008145	FtsH Extracellular; Region: FtsH_ext; pfam06480
596154008146	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
596154008147	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154008148	Walker A motif; other site
596154008149	ATP binding site [chemical binding]; other site
596154008150	Walker B motif; other site
596154008151	arginine finger; other site
596154008152	Peptidase family M41; Region: Peptidase_M41; pfam01434
596154008153	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
596154008154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154008155	S-adenosylmethionine binding site [chemical binding]; other site
596154008156	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
596154008157	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
596154008158	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
596154008159	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
596154008160	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
596154008161	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
596154008162	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
596154008163	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
596154008164	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
596154008165	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
596154008166	ATP-grasp domain; Region: ATP-grasp_4; cl17255
596154008167	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
596154008168	IMP binding site; other site
596154008169	dimer interface [polypeptide binding]; other site
596154008170	interdomain contacts; other site
596154008171	partial ornithine binding site; other site
596154008172	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
596154008173	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
596154008174	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
596154008175	catalytic site [active]
596154008176	subunit interface [polypeptide binding]; other site
596154008177	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
596154008178	active site
596154008179	Int/Topo IB signature motif; other site
596154008180	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
596154008181	Transposase; Region: HTH_Tnp_1; cl17663
596154008182	integrase; Provisional; Region: PRK09692
596154008183	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
596154008184	active site
596154008185	Int/Topo IB signature motif; other site
596154008186	ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187
596154008187	ATP-grasp domain; Region: ATP-grasp_4; cl17255
596154008188	Restriction endonuclease; Region: Mrr_cat; pfam04471
596154008189	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
596154008190	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
596154008191	Part of AAA domain; Region: AAA_19; pfam13245
596154008192	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
596154008193	putative active site [active]
596154008194	putative metal-binding site [ion binding]; other site
596154008195	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
596154008196	IHF dimer interface [polypeptide binding]; other site
596154008197	Transposase; Region: HTH_Tnp_1; pfam01527
596154008198	putative transposase OrfB; Reviewed; Region: PHA02517
596154008199	HTH-like domain; Region: HTH_21; pfam13276
596154008200	Integrase core domain; Region: rve; pfam00665
596154008201	Integrase core domain; Region: rve_3; pfam13683
596154008202	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154008203	S-adenosylmethionine binding site [chemical binding]; other site
596154008204	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
596154008205	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
596154008206	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
596154008207	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
596154008208	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
596154008209	Outer membrane efflux protein; Region: OEP; pfam02321
596154008210	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365
596154008211	Outer membrane efflux protein; Region: OEP; pfam02321
596154008212	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
596154008213	Acetokinase family; Region: Acetate_kinase; cl17229
596154008214	propionate/acetate kinase; Provisional; Region: PRK12379
596154008215	Helix-Turn-Helix DNA binding domain of putative Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR_unk; cd04787
596154008216	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
596154008217	DNA binding residues [nucleotide binding]
596154008218	dimer interface [polypeptide binding]; other site
596154008219	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
596154008220	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154008221	S-adenosylmethionine binding site [chemical binding]; other site
596154008222	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
596154008223	XFP N-terminal domain; Region: XFP_N; pfam09364
596154008224	glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PRK04207
596154008225	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
596154008226	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
596154008227	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
596154008228	ABC1 family; Region: ABC1; cl17513
596154008229	D-Lactate and related Dehydrogenase like proteins, NAD-binding and catalytic domains; Region: LDH_like_1; cd12187
596154008230	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
596154008231	ligand binding site [chemical binding]; other site
596154008232	NAD binding site [chemical binding]; other site
596154008233	homodimer interface [polypeptide binding]; other site
596154008234	catalytic site [active]
596154008235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154008236	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
596154008237	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
596154008238	protein binding site [polypeptide binding]; other site
596154008239	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
596154008240	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
596154008241	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
596154008242	active site
596154008243	thymidine phosphorylase; Provisional; Region: PRK04350
596154008244	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
596154008245	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
596154008246	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
596154008247	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
596154008248	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
596154008249	Beta-Casp domain; Region: Beta-Casp; smart01027
596154008250	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
596154008251	Repair protein; Region: Repair_PSII; pfam04536
596154008252	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
596154008253	Repair protein; Region: Repair_PSII; pfam04536
596154008254	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
596154008255	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
596154008256	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
596154008257	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
596154008258	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
596154008259	motif II; other site
596154008260	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
596154008261	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
596154008262	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
596154008263	DNA binding residues [nucleotide binding]
596154008264	dimer interface [polypeptide binding]; other site
596154008265	mercury binding site [ion binding]; other site
596154008266	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
596154008267	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
596154008268	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
596154008269	Trehalase; Region: Trehalase; cl17346
596154008270	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154008271	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
596154008272	Outer membrane efflux protein; Region: OEP; pfam02321
596154008273	Outer membrane efflux protein; Region: OEP; pfam02321
596154008274	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
596154008275	Predicted membrane protein [Function unknown]; Region: COG3174
596154008276	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
596154008277	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
596154008278	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
596154008279	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
596154008280	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
596154008281	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
596154008282	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
596154008283	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
596154008284	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
596154008285	YHS domain; Region: YHS; pfam04945
596154008286	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
596154008287	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
596154008288	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
596154008289	motif II; other site
596154008290	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
596154008291	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
596154008292	metal-binding site [ion binding]
596154008293	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
596154008294	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
596154008295	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
596154008296	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
596154008297	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154008298	active site
596154008299	phosphorylation site [posttranslational modification]
596154008300	intermolecular recognition site; other site
596154008301	dimerization interface [polypeptide binding]; other site
596154008302	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
596154008303	DNA binding site [nucleotide binding]
596154008304	putative transposase OrfB; Reviewed; Region: PHA02517
596154008305	HTH-like domain; Region: HTH_21; pfam13276
596154008306	Integrase core domain; Region: rve; pfam00665
596154008307	Integrase core domain; Region: rve_3; cl15866
596154008308	Transposase; Region: HTH_Tnp_1; cl17663
596154008309	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
596154008310	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
596154008311	active site 1 [active]
596154008312	active site 2 [active]
596154008313	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
596154008314	PRTRC system protein D; Region: PRTRC_D; TIGR03739
596154008315	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
596154008316	Mg binding site [ion binding]; other site
596154008317	nucleotide binding site [chemical binding]; other site
596154008318	putative protofilament interface [polypeptide binding]; other site
596154008319	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
596154008320	Integrase; Region: Integrase_1; pfam12835
596154008321	H-NS histone family; Region: Histone_HNS; pfam00816
596154008322	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
596154008323	Domain of unknown function (DUF2016); Region: DUF2016; pfam09436
596154008324	PRTRC system protein A; Region: PRTRC_A; TIGR03735
596154008325	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
596154008326	Prokaryotic E2 family D; Region: Prok-E2_D; cl14019
596154008327	Homeodomain-like domain; Region: HTH_23; pfam13384
596154008328	Winged helix-turn helix; Region: HTH_29; pfam13551
596154008329	DDE superfamily endonuclease; Region: DDE_3; pfam13358
596154008330	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
596154008331	PRTRC system protein C; Region: PRTRC_C; TIGR03738
596154008332	PRTRC system protein E; Region: PRTRC_E; TIGR03741
596154008333	ParB-like nuclease domain; Region: ParB; smart00470
596154008334	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
596154008335	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
596154008336	DEAD-like helicases superfamily; Region: DEXDc; smart00487
596154008337	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
596154008338	ATP binding site [chemical binding]; other site
596154008339	putative Mg++ binding site [ion binding]; other site
596154008340	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
596154008341	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
596154008342	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
596154008343	Transposase; Region: HTH_Tnp_1; pfam01527
596154008344	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
596154008345	NADH dehydrogenase subunit 4; Provisional; Region: ND4; MTH00217
596154008346	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
596154008347	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
596154008348	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
596154008349	active site
596154008350	metal binding site [ion binding]; metal-binding site
596154008351	interdomain interaction site; other site
596154008352	Domain of unknown function (DUF932); Region: DUF932; cl12129
596154008353	Predicted transcriptional regulator [Transcription]; Region: COG2932
596154008354	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
596154008355	Catalytic site [active]
596154008356	Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036
596154008357	Putative helicase; Region: TraI_2; pfam07514
596154008358	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
596154008359	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
596154008360	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
596154008361	Domain of unknown function (DUF4400); Region: DUF4400; cl14023
596154008362	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154008363	sequence-specific DNA binding site [nucleotide binding]; other site
596154008364	salt bridge; other site
596154008365	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
596154008366	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
596154008367	N-acetyl-D-glucosamine binding site [chemical binding]; other site
596154008368	catalytic residue [active]
596154008369	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
596154008370	ligand binding site [chemical binding]; other site
596154008371	TraL protein; Region: TraL; cl06278
596154008372	TraE protein; Region: TraE; cl05060
596154008373	TraK protein; Region: TraK; pfam06586
596154008374	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
596154008375	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
596154008376	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
596154008377	dimerization domain [polypeptide binding]; other site
596154008378	dimer interface [polypeptide binding]; other site
596154008379	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
596154008380	catalytic residues [active]
596154008381	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
596154008382	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
596154008383	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
596154008384	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
596154008385	Walker A motif; other site
596154008386	ATP binding site [chemical binding]; other site
596154008387	conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771
596154008388	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
596154008389	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
596154008390	TraU protein; Region: TraU; pfam06834
596154008391	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883
596154008392	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
596154008393	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
596154008394	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
596154008395	F plasmid transfer operon protein; Region: TraF; pfam13728
596154008396	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
596154008397	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
596154008398	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
596154008399	active site
596154008400	substrate binding sites [chemical binding]; other site
596154008401	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
596154008402	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
596154008403	DNA binding residues [nucleotide binding]
596154008404	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
596154008405	IHF - DNA interface [nucleotide binding]; other site
596154008406	IHF dimer interface [polypeptide binding]; other site
596154008407	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
596154008408	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
596154008409	putative tRNA-binding site [nucleotide binding]; other site
596154008410	B3/4 domain; Region: B3_4; pfam03483
596154008411	tRNA synthetase B5 domain; Region: B5; smart00874
596154008412	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
596154008413	dimer interface [polypeptide binding]; other site
596154008414	motif 1; other site
596154008415	motif 3; other site
596154008416	motif 2; other site
596154008417	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
596154008418	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
596154008419	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
596154008420	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
596154008421	dimer interface [polypeptide binding]; other site
596154008422	motif 1; other site
596154008423	active site
596154008424	motif 2; other site
596154008425	motif 3; other site
596154008426	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
596154008427	23S rRNA binding site [nucleotide binding]; other site
596154008428	L21 binding site [polypeptide binding]; other site
596154008429	L13 binding site [polypeptide binding]; other site
596154008430	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
596154008431	translation initiation factor IF-3; Region: infC; TIGR00168
596154008432	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
596154008433	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
596154008434	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
596154008435	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
596154008436	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
596154008437	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
596154008438	active site
596154008439	dimer interface [polypeptide binding]; other site
596154008440	motif 1; other site
596154008441	motif 2; other site
596154008442	motif 3; other site
596154008443	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
596154008444	anticodon binding site; other site
596154008445	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
596154008446	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
596154008447	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
596154008448	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
596154008449	isocitrate lyase; Provisional; Region: PRK15063
596154008450	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
596154008451	tetramer interface [polypeptide binding]; other site
596154008452	active site
596154008453	Mg2+/Mn2+ binding site [ion binding]; other site
596154008454	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
596154008455	EamA-like transporter family; Region: EamA; pfam00892
596154008456	EamA-like transporter family; Region: EamA; pfam00892
596154008457	SWIB/MDM2 domain; Region: SWIB; pfam02201
596154008458	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
596154008459	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
596154008460	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
596154008461	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
596154008462	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
596154008463	TolR protein; Region: tolR; TIGR02801
596154008464	Hemin uptake protein hemP; Region: hemP; pfam10636
596154008465	Domain of unknown function (DUF336); Region: DUF336; cl01249
596154008466	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
596154008467	YccA-like proteins; Region: YccA_like; cd10433
596154008468	MarR family; Region: MarR_2; cl17246
596154008469	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
596154008470	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
596154008471	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154008472	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
596154008473	Chromate transporter; Region: Chromate_transp; pfam02417
596154008474	Chromate transporter; Region: Chromate_transp; pfam02417
596154008475	NAD-dependent deacetylase; Provisional; Region: PRK00481
596154008476	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
596154008477	NAD+ binding site [chemical binding]; other site
596154008478	substrate binding site [chemical binding]; other site
596154008479	Zn binding site [ion binding]; other site
596154008480	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154008481	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154008482	WHG domain; Region: WHG; pfam13305
596154008483	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
596154008484	Uncharacterized conserved protein [Function unknown]; Region: COG3791
596154008485	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
596154008486	dimer interface [polypeptide binding]; other site
596154008487	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
596154008488	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
596154008489	putative hydrophobic ligand binding site [chemical binding]; other site
596154008490	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
596154008491	dimer interface [polypeptide binding]; other site
596154008492	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
596154008493	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
596154008494	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
596154008495	putative hydrophobic ligand binding site [chemical binding]; other site
596154008496	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
596154008497	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
596154008498	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
596154008499	serine/threonine transporter SstT; Provisional; Region: PRK13628
596154008500	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
596154008501	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
596154008502	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
596154008503	Walker A/P-loop; other site
596154008504	ATP binding site [chemical binding]; other site
596154008505	Q-loop/lid; other site
596154008506	ABC transporter signature motif; other site
596154008507	Walker B; other site
596154008508	D-loop; other site
596154008509	H-loop/switch region; other site
596154008510	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
596154008511	active site
596154008512	catalytic triad [active]
596154008513	oxyanion hole [active]
596154008514	switch loop; other site
596154008515	Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955
596154008516	cystathionine beta-lyase; Provisional; Region: PRK07050
596154008517	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
596154008518	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
596154008519	catalytic residue [active]
596154008520	BON domain; Region: BON; pfam04972
596154008521	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
596154008522	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
596154008523	Sulfate transporter family; Region: Sulfate_transp; pfam00916
596154008524	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
596154008525	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154008526	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154008527	metal binding site [ion binding]; metal-binding site
596154008528	active site
596154008529	I-site; other site
596154008530	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
596154008531	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
596154008532	P-loop; other site
596154008533	ADP binding residues [chemical binding]; other site
596154008534	Switch I; other site
596154008535	Switch II; other site
596154008536	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
596154008537	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154008538	acyl-activating enzyme (AAE) consensus motif; other site
596154008539	AMP binding site [chemical binding]; other site
596154008540	active site
596154008541	CoA binding site [chemical binding]; other site
596154008542	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
596154008543	Isochorismatase family; Region: Isochorismatase; pfam00857
596154008544	catalytic triad [active]
596154008545	dimer interface [polypeptide binding]; other site
596154008546	conserved cis-peptide bond; other site
596154008547	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
596154008548	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
596154008549	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
596154008550	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154008551	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154008552	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154008553	dimerization interface [polypeptide binding]; other site
596154008554	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
596154008555	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
596154008556	tetrameric interface [polypeptide binding]; other site
596154008557	NAD binding site [chemical binding]; other site
596154008558	catalytic residues [active]
596154008559	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
596154008560	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154008561	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154008562	active site
596154008563	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
596154008564	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
596154008565	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
596154008566	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
596154008567	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
596154008568	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154008569	catalytic residue [active]
596154008570	Protein with unknown function (DUF469); Region: DUF469; pfam04320
596154008571	galactarate dehydratase; Region: galactar-dH20; TIGR03248
596154008572	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
596154008573	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
596154008574	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154008575	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
596154008576	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
596154008577	active site
596154008578	tetramer interface [polypeptide binding]; other site
596154008579	transcriptional regulator NanR; Provisional; Region: PRK03837
596154008580	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154008581	DNA-binding site [nucleotide binding]; DNA binding site
596154008582	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
596154008583	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154008584	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
596154008585	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
596154008586	putative active site [active]
596154008587	catalytic residue [active]
596154008588	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154008589	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
596154008590	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
596154008591	putative ligand binding site [chemical binding]; other site
596154008592	NAD binding site [chemical binding]; other site
596154008593	catalytic site [active]
596154008594	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
596154008595	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
596154008596	active site
596154008597	tetramer interface [polypeptide binding]; other site
596154008598	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
596154008599	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
596154008600	NAD(P) binding site [chemical binding]; other site
596154008601	catalytic residues [active]
596154008602	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
596154008603	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
596154008604	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
596154008605	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
596154008606	Pirin-related protein [General function prediction only]; Region: COG1741
596154008607	Pirin; Region: Pirin; pfam02678
596154008608	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154008609	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154008610	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154008611	dimerization interface [polypeptide binding]; other site
596154008612	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
596154008613	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
596154008614	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
596154008615	active site
596154008616	HIGH motif; other site
596154008617	nucleotide binding site [chemical binding]; other site
596154008618	active site
596154008619	KMSKS motif; other site
596154008620	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154008621	S-adenosylmethionine binding site [chemical binding]; other site
596154008622	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154008623	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154008624	metal binding site [ion binding]; metal-binding site
596154008625	active site
596154008626	I-site; other site
596154008627	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
596154008628	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
596154008629	motif 1; other site
596154008630	active site
596154008631	motif 2; other site
596154008632	motif 3; other site
596154008633	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
596154008634	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
596154008635	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
596154008636	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
596154008637	inhibitor site; inhibition site
596154008638	active site
596154008639	dimer interface [polypeptide binding]; other site
596154008640	catalytic residue [active]
596154008641	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
596154008642	DctM-like transporters; Region: DctM; pfam06808
596154008643	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
596154008644	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
596154008645	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
596154008646	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
596154008647	Transcriptional regulators [Transcription]; Region: GntR; COG1802
596154008648	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154008649	DNA-binding site [nucleotide binding]; DNA binding site
596154008650	FCD domain; Region: FCD; pfam07729
596154008651	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
596154008652	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
596154008653	probable active site [active]
596154008654	CoA binding domain; Region: CoA_binding_2; pfam13380
596154008655	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
596154008656	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
596154008657	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
596154008658	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
596154008659	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
596154008660	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
596154008661	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
596154008662	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
596154008663	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
596154008664	active site
596154008665	substrate binding site [chemical binding]; other site
596154008666	metal binding site [ion binding]; metal-binding site
596154008667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154008668	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154008669	KduI/IolB family; Region: KduI; cl01508
596154008670	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
596154008671	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
596154008672	substrate binding site [chemical binding]; other site
596154008673	ATP binding site [chemical binding]; other site
596154008674	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
596154008675	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
596154008676	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
596154008677	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
596154008678	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
596154008679	putative active site [active]
596154008680	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
596154008681	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
596154008682	Helix-turn-helix domain; Region: HTH_18; pfam12833
596154008683	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
596154008684	AlkA N-terminal domain; Region: AlkA_N; pfam06029
596154008685	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
596154008686	minor groove reading motif; other site
596154008687	helix-hairpin-helix signature motif; other site
596154008688	active site
596154008689	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
596154008690	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
596154008691	DNA binding site [nucleotide binding]
596154008692	active site
596154008693	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
596154008694	EamA-like transporter family; Region: EamA; pfam00892
596154008695	cyclase homology domain; Region: CHD; cd07302
596154008696	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
596154008697	nucleotidyl binding site; other site
596154008698	metal binding site [ion binding]; metal-binding site
596154008699	dimer interface [polypeptide binding]; other site
596154008700	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
596154008701	phosphopeptide binding site; other site
596154008702	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
596154008703	dimer interface [polypeptide binding]; other site
596154008704	catalytic triad [active]
596154008705	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
596154008706	nucleoside/Zn binding site; other site
596154008707	dimer interface [polypeptide binding]; other site
596154008708	catalytic motif [active]
596154008709	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
596154008710	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
596154008711	Peptidase family U32; Region: Peptidase_U32; pfam01136
596154008712	Collagenase; Region: DUF3656; pfam12392
596154008713	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
596154008714	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
596154008715	homodimer interface [polypeptide binding]; other site
596154008716	substrate-cofactor binding pocket; other site
596154008717	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154008718	catalytic residue [active]
596154008719	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
596154008720	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
596154008721	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
596154008722	Methyltransferase domain; Region: Methyltransf_26; pfam13659
596154008723	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
596154008724	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
596154008725	Protein of unknown function (DUF808); Region: DUF808; pfam05661
596154008726	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
596154008727	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
596154008728	dimerization interface [polypeptide binding]; other site
596154008729	ATP binding site [chemical binding]; other site
596154008730	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
596154008731	dimerization interface [polypeptide binding]; other site
596154008732	ATP binding site [chemical binding]; other site
596154008733	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
596154008734	putative active site [active]
596154008735	catalytic triad [active]
596154008736	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
596154008737	active site
596154008738	PII uridylyl-transferase; Provisional; Region: PRK03059
596154008739	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
596154008740	metal binding triad; other site
596154008741	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
596154008742	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
596154008743	Zn2+ binding site [ion binding]; other site
596154008744	Mg2+ binding site [ion binding]; other site
596154008745	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
596154008746	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
596154008747	xanthine permease; Region: pbuX; TIGR03173
596154008748	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
596154008749	active site
596154008750	catalytic residues [active]
596154008751	metal binding site [ion binding]; metal-binding site
596154008752	Protein of unknown function (DUF454); Region: DUF454; cl01063
596154008753	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
596154008754	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
596154008755	AAA domain; Region: AAA_33; pfam13671
596154008756	isocitrate dehydrogenase; Validated; Region: PRK07362
596154008757	isocitrate dehydrogenase; Reviewed; Region: PRK07006
596154008758	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
596154008759	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
596154008760	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
596154008761	superoxide dismutase; Provisional; Region: PRK10543
596154008762	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
596154008763	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
596154008764	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
596154008765	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
596154008766	generic binding surface II; other site
596154008767	generic binding surface I; other site
596154008768	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
596154008769	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
596154008770	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
596154008771	tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906
596154008772	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
596154008773	Uncharacterized conserved protein [Function unknown]; Region: COG2835
596154008774	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
596154008775	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
596154008776	Ligand binding site; other site
596154008777	oligomer interface; other site
596154008778	adenylate kinase; Reviewed; Region: adk; PRK00279
596154008779	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
596154008780	AMP-binding site [chemical binding]; other site
596154008781	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
596154008782	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
596154008783	active site
596154008784	homotetramer interface [polypeptide binding]; other site
596154008785	homodimer interface [polypeptide binding]; other site
596154008786	LexA repressor; Validated; Region: PRK00215
596154008787	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
596154008788	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
596154008789	Catalytic site [active]
596154008790	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
596154008791	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
596154008792	ATP binding site [chemical binding]; other site
596154008793	putative Mg++ binding site [ion binding]; other site
596154008794	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
596154008795	nucleotide binding region [chemical binding]; other site
596154008796	ATP-binding site [chemical binding]; other site
596154008797	Helicase associated domain (HA2); Region: HA2; pfam04408
596154008798	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
596154008799	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
596154008800	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
596154008801	active site
596154008802	acyl-CoA synthetase; Validated; Region: PRK07638
596154008803	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154008804	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
596154008805	acyl-activating enzyme (AAE) consensus motif; other site
596154008806	acyl-activating enzyme (AAE) consensus motif; other site
596154008807	AMP binding site [chemical binding]; other site
596154008808	active site
596154008809	CoA binding site [chemical binding]; other site
596154008810	BioY family; Region: BioY; pfam02632
596154008811	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154008812	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
596154008813	Walker A/P-loop; other site
596154008814	ATP binding site [chemical binding]; other site
596154008815	Q-loop/lid; other site
596154008816	ABC transporter signature motif; other site
596154008817	Walker B; other site
596154008818	D-loop; other site
596154008819	H-loop/switch region; other site
596154008820	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
596154008821	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
596154008822	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
596154008823	dimer interface [polypeptide binding]; other site
596154008824	active site
596154008825	metal binding site [ion binding]; metal-binding site
596154008826	glutathione binding site [chemical binding]; other site
596154008827	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
596154008828	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
596154008829	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154008830	Walker A motif; other site
596154008831	ATP binding site [chemical binding]; other site
596154008832	Walker B motif; other site
596154008833	arginine finger; other site
596154008834	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
596154008835	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154008836	non-specific DNA binding site [nucleotide binding]; other site
596154008837	salt bridge; other site
596154008838	sequence-specific DNA binding site [nucleotide binding]; other site
596154008839	Integrase core domain; Region: rve; pfam00665
596154008840	Uncharacterized conserved protein [Function unknown]; Region: COG5489
596154008841	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
596154008842	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154008843	non-specific DNA binding site [nucleotide binding]; other site
596154008844	salt bridge; other site
596154008845	sequence-specific DNA binding site [nucleotide binding]; other site
596154008846	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
596154008847	Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246
596154008848	Helix-turn-helix domain; Region: HTH_17; cl17695
596154008849	Replication initiator protein A; Region: RPA; pfam10134
596154008850	ParA-like protein; Provisional; Region: PHA02518
596154008851	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
596154008852	P-loop; other site
596154008853	Magnesium ion binding site [ion binding]; other site
596154008854	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
596154008855	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
596154008856	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
596154008857	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
596154008858	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
596154008859	ferrochelatase; Reviewed; Region: hemH; PRK00035
596154008860	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
596154008861	C-terminal domain interface [polypeptide binding]; other site
596154008862	active site
596154008863	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
596154008864	active site
596154008865	N-terminal domain interface [polypeptide binding]; other site
596154008866	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
596154008867	RibD C-terminal domain; Region: RibD_C; cl17279
596154008868	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
596154008869	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
596154008870	NADH dehydrogenase subunit L; Provisional; Region: PRK08168
596154008871	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
596154008872	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154008873	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154008874	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
596154008875	dimerization interface [polypeptide binding]; other site
596154008876	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
596154008877	tellurium resistance terB-like protein; Region: terB_like; cd07177
596154008878	metal binding site [ion binding]; metal-binding site
596154008879	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
596154008880	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
596154008881	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154008882	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
596154008883	putative dimerization interface [polypeptide binding]; other site
596154008884	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
596154008885	catalytic residues [active]
596154008886	dimer interface [polypeptide binding]; other site
596154008887	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
596154008888	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154008889	NAD(P) binding site [chemical binding]; other site
596154008890	active site
596154008891	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154008892	NAD(P) binding site [chemical binding]; other site
596154008893	active site
596154008894	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
596154008895	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
596154008896	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
596154008897	Fasciclin domain; Region: Fasciclin; pfam02469
596154008898	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
596154008899	Fasciclin domain; Region: Fasciclin; pfam02469
596154008900	DNA photolyase; Region: DNA_photolyase; pfam00875
596154008901	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
596154008902	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
596154008903	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
596154008904	DNA binding residues [nucleotide binding]
596154008905	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
596154008906	B12 binding domain; Region: B12-binding_2; pfam02607
596154008907	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
596154008908	B12 binding site [chemical binding]; other site
596154008909	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
596154008910	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
596154008911	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
596154008912	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
596154008913	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
596154008914	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154008915	S-adenosylmethionine binding site [chemical binding]; other site
596154008916	MFS/sugar transport protein; Region: MFS_2; pfam13347
596154008917	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
596154008918	short chain dehydrogenase; Provisional; Region: PRK06101
596154008919	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154008920	NAD(P) binding site [chemical binding]; other site
596154008921	active site
596154008922	SnoaL-like domain; Region: SnoaL_2; pfam12680
596154008923	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
596154008924	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
596154008925	putative C-terminal domain interface [polypeptide binding]; other site
596154008926	putative GSH binding site (G-site) [chemical binding]; other site
596154008927	putative dimer interface [polypeptide binding]; other site
596154008928	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
596154008929	putative N-terminal domain interface [polypeptide binding]; other site
596154008930	putative dimer interface [polypeptide binding]; other site
596154008931	putative substrate binding pocket (H-site) [chemical binding]; other site
596154008932	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
596154008933	DNA photolyase; Region: DNA_photolyase; pfam00875
596154008934	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154008935	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154008936	dimerization interface [polypeptide binding]; other site
596154008937	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
596154008938	Integrase core domain; Region: rve; pfam00665
596154008939	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
596154008940	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154008941	Walker A motif; other site
596154008942	ATP binding site [chemical binding]; other site
596154008943	Walker B motif; other site
596154008944	arginine finger; other site
596154008945	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
596154008946	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
596154008947	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
596154008948	active site
596154008949	Int/Topo IB signature motif; other site
596154008950	DNA binding site [nucleotide binding]
596154008951	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
596154008952	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154008953	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
596154008954	dimerizarion interface [polypeptide binding]; other site
596154008955	CrgA pocket; other site
596154008956	substrate binding pocket [chemical binding]; other site
596154008957	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
596154008958	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
596154008959	active site
596154008960	intersubunit interface [polypeptide binding]; other site
596154008961	catalytic residue [active]
596154008962	phosphogluconate dehydratase; Validated; Region: PRK09054
596154008963	6-phosphogluconate dehydratase; Region: edd; TIGR01196
596154008964	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
596154008965	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
596154008966	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
596154008967	DctM-like transporters; Region: DctM; pfam06808
596154008968	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
596154008969	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
596154008970	ATP-binding site [chemical binding]; other site
596154008971	Gluconate-6-phosphate binding site [chemical binding]; other site
596154008972	Transcriptional regulators [Transcription]; Region: PurR; COG1609
596154008973	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
596154008974	DNA binding site [nucleotide binding]
596154008975	domain linker motif; other site
596154008976	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
596154008977	putative ligand binding site [chemical binding]; other site
596154008978	putative dimerization interface [polypeptide binding]; other site
596154008979	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
596154008980	Clp amino terminal domain; Region: Clp_N; pfam02861
596154008981	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154008982	Walker A motif; other site
596154008983	ATP binding site [chemical binding]; other site
596154008984	Walker B motif; other site
596154008985	arginine finger; other site
596154008986	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154008987	Walker A motif; other site
596154008988	ATP binding site [chemical binding]; other site
596154008989	Walker B motif; other site
596154008990	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
596154008991	Uncharacterized conserved protein [Function unknown]; Region: COG2127
596154008992	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
596154008993	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
596154008994	putative active site [active]
596154008995	putative PHP Thumb interface [polypeptide binding]; other site
596154008996	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
596154008997	generic binding surface II; other site
596154008998	generic binding surface I; other site
596154008999	Outer membrane lipoprotein; Region: YfiO; pfam13525
596154009000	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
596154009001	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
596154009002	DEAD_2; Region: DEAD_2; pfam06733
596154009003	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
596154009004	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
596154009005	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
596154009006	active site
596154009007	Predicted ATPase [General function prediction only]; Region: COG1485
596154009008	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
596154009009	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
596154009010	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
596154009011	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
596154009012	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
596154009013	E3 interaction surface; other site
596154009014	lipoyl attachment site [posttranslational modification]; other site
596154009015	e3 binding domain; Region: E3_binding; pfam02817
596154009016	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
596154009017	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
596154009018	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
596154009019	TPP-binding site [chemical binding]; other site
596154009020	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
596154009021	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
596154009022	Domain of unknown function DUF20; Region: UPF0118; pfam01594
596154009023	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154009024	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
596154009025	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154009026	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154009027	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
596154009028	putative dimerization interface [polypeptide binding]; other site
596154009029	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
596154009030	Ligand Binding Site [chemical binding]; other site
596154009031	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
596154009032	Ligand Binding Site [chemical binding]; other site
596154009033	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
596154009034	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
596154009035	Walker A/P-loop; other site
596154009036	ATP binding site [chemical binding]; other site
596154009037	Q-loop/lid; other site
596154009038	ABC transporter signature motif; other site
596154009039	Walker B; other site
596154009040	D-loop; other site
596154009041	H-loop/switch region; other site
596154009042	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
596154009043	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
596154009044	Walker A/P-loop; other site
596154009045	ATP binding site [chemical binding]; other site
596154009046	Q-loop/lid; other site
596154009047	ABC transporter signature motif; other site
596154009048	Walker B; other site
596154009049	D-loop; other site
596154009050	H-loop/switch region; other site
596154009051	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
596154009052	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
596154009053	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
596154009054	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154009055	dimer interface [polypeptide binding]; other site
596154009056	conserved gate region; other site
596154009057	putative PBP binding loops; other site
596154009058	ABC-ATPase subunit interface; other site
596154009059	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
596154009060	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154009061	dimer interface [polypeptide binding]; other site
596154009062	conserved gate region; other site
596154009063	putative PBP binding loops; other site
596154009064	ABC-ATPase subunit interface; other site
596154009065	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
596154009066	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
596154009067	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
596154009068	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997
596154009069	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
596154009070	NAD binding site [chemical binding]; other site
596154009071	homotetramer interface [polypeptide binding]; other site
596154009072	homodimer interface [polypeptide binding]; other site
596154009073	substrate binding site [chemical binding]; other site
596154009074	active site
596154009075	aromatic amino acid exporter; Provisional; Region: PRK11689
596154009076	EamA-like transporter family; Region: EamA; pfam00892
596154009077	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
596154009078	DNA ligase; Provisional; Region: PRK09125
596154009079	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
596154009080	DNA binding site [nucleotide binding]
596154009081	active site
596154009082	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
596154009083	DNA binding site [nucleotide binding]
596154009084	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
596154009085	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
596154009086	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
596154009087	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
596154009088	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
596154009089	catalytic residue [active]
596154009090	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
596154009091	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
596154009092	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
596154009093	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
596154009094	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
596154009095	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154009096	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
596154009097	dimerization interface [polypeptide binding]; other site
596154009098	substrate binding pocket [chemical binding]; other site
596154009099	thiamine pyrophosphate protein; Validated; Region: PRK08199
596154009100	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
596154009101	PYR/PP interface [polypeptide binding]; other site
596154009102	dimer interface [polypeptide binding]; other site
596154009103	TPP binding site [chemical binding]; other site
596154009104	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
596154009105	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
596154009106	TPP-binding site [chemical binding]; other site
596154009107	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311
596154009108	putative active site [active]
596154009109	catalytic site [active]
596154009110	putative transposase OrfB; Reviewed; Region: PHA02517
596154009111	HTH-like domain; Region: HTH_21; pfam13276
596154009112	Integrase core domain; Region: rve; pfam00665
596154009113	Integrase core domain; Region: rve_3; cl15866
596154009114	Transposase; Region: HTH_Tnp_1; cl17663
596154009115	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
596154009116	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
596154009117	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
596154009118	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
596154009119	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
596154009120	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
596154009121	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
596154009122	active site
596154009123	substrate binding site [chemical binding]; other site
596154009124	Mg2+ binding site [ion binding]; other site
596154009125	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
596154009126	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
596154009127	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
596154009128	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
596154009129	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
596154009130	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
596154009131	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
596154009132	Transposase; Region: HTH_Tnp_1; pfam01527
596154009133	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
596154009134	phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299
596154009135	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
596154009136	Short C-terminal domain; Region: SHOCT; pfam09851
596154009137	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
596154009138	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154009139	non-specific DNA binding site [nucleotide binding]; other site
596154009140	salt bridge; other site
596154009141	sequence-specific DNA binding site [nucleotide binding]; other site
596154009142	DNA polymerase II; Reviewed; Region: PRK05762
596154009143	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
596154009144	active site
596154009145	catalytic site [active]
596154009146	substrate binding site [chemical binding]; other site
596154009147	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
596154009148	active site
596154009149	metal-binding site
596154009150	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
596154009151	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
596154009152	integrase; Provisional; Region: PRK09692
596154009153	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
596154009154	active site
596154009155	Int/Topo IB signature motif; other site
596154009156	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
596154009157	Sel1 repeat; Region: Sel1; cl02723
596154009158	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
596154009159	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
596154009160	N-acetyl-D-glucosamine binding site [chemical binding]; other site
596154009161	catalytic residue [active]
596154009162	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
596154009163	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154009164	NAD(P) binding site [chemical binding]; other site
596154009165	active site
596154009166	crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155
596154009167	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154009168	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
596154009169	acyl-activating enzyme (AAE) consensus motif; other site
596154009170	putative AMP binding site [chemical binding]; other site
596154009171	putative active site [active]
596154009172	putative CoA binding site [chemical binding]; other site
596154009173	Uncharacterized conserved protein [Function unknown]; Region: COG2128
596154009174	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
596154009175	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
596154009176	Walker A/P-loop; other site
596154009177	ATP binding site [chemical binding]; other site
596154009178	Q-loop/lid; other site
596154009179	ABC transporter signature motif; other site
596154009180	Walker B; other site
596154009181	D-loop; other site
596154009182	H-loop/switch region; other site
596154009183	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
596154009184	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
596154009185	Walker A/P-loop; other site
596154009186	ATP binding site [chemical binding]; other site
596154009187	Q-loop/lid; other site
596154009188	ABC transporter signature motif; other site
596154009189	Walker B; other site
596154009190	D-loop; other site
596154009191	H-loop/switch region; other site
596154009192	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
596154009193	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
596154009194	TM-ABC transporter signature motif; other site
596154009195	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
596154009196	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154009197	TM-ABC transporter signature motif; other site
596154009198	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154009199	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
596154009200	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
596154009201	classical (c) SDRs; Region: SDR_c; cd05233
596154009202	NAD(P) binding site [chemical binding]; other site
596154009203	active site
596154009204	lipid-transfer protein; Provisional; Region: PRK08256
596154009205	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
596154009206	active site
596154009207	acyl-CoA synthetase; Validated; Region: PRK06188
596154009208	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154009209	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
596154009210	acyl-activating enzyme (AAE) consensus motif; other site
596154009211	acyl-activating enzyme (AAE) consensus motif; other site
596154009212	putative AMP binding site [chemical binding]; other site
596154009213	putative active site [active]
596154009214	putative CoA binding site [chemical binding]; other site
596154009215	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154009216	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
596154009217	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
596154009218	substrate binding pocket [chemical binding]; other site
596154009219	membrane-bound complex binding site; other site
596154009220	hinge residues; other site
596154009221	oxidative damage protection protein; Provisional; Region: PRK05408
596154009222	Predicted membrane protein [Function unknown]; Region: COG2860
596154009223	UPF0126 domain; Region: UPF0126; pfam03458
596154009224	UPF0126 domain; Region: UPF0126; pfam03458
596154009225	Uncharacterized conserved protein [Function unknown]; Region: COG4121
596154009226	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
596154009227	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
596154009228	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
596154009229	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
596154009230	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
596154009231	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
596154009232	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
596154009233	Active Sites [active]
596154009234	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
596154009235	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
596154009236	Active Sites [active]
596154009237	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
596154009238	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
596154009239	G1 box; other site
596154009240	GTP/Mg2+ binding site [chemical binding]; other site
596154009241	G2 box; other site
596154009242	Switch I region; other site
596154009243	G3 box; other site
596154009244	Switch II region; other site
596154009245	G4 box; other site
596154009246	G5 box; other site
596154009247	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
596154009248	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
596154009249	Ferredoxin [Energy production and conversion]; Region: COG1146
596154009250	4Fe-4S binding domain; Region: Fer4; cl02805
596154009251	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
596154009252	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
596154009253	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
596154009254	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
596154009255	Bacterial SH3 domain; Region: SH3_4; pfam06347
596154009256	Bacterial SH3 domain; Region: SH3_3; pfam08239
596154009257	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
596154009258	dimer interface [polypeptide binding]; other site
596154009259	substrate binding site [chemical binding]; other site
596154009260	ATP binding site [chemical binding]; other site
596154009261	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
596154009262	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
596154009263	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
596154009264	thiS-thiF/thiG interaction site; other site
596154009265	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
596154009266	ThiS interaction site; other site
596154009267	putative active site [active]
596154009268	tetramer interface [polypeptide binding]; other site
596154009269	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
596154009270	thiamine phosphate binding site [chemical binding]; other site
596154009271	active site
596154009272	pyrophosphate binding site [ion binding]; other site
596154009273	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
596154009274	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
596154009275	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
596154009276	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
596154009277	enoyl-CoA hydratase; Provisional; Region: PRK07511
596154009278	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154009279	substrate binding site [chemical binding]; other site
596154009280	oxyanion hole (OAH) forming residues; other site
596154009281	trimer interface [polypeptide binding]; other site
596154009282	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
596154009283	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
596154009284	ligand binding site [chemical binding]; other site
596154009285	flexible hinge region; other site
596154009286	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
596154009287	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
596154009288	Phosphotransferase enzyme family; Region: APH; pfam01636
596154009289	putative active site [active]
596154009290	putative substrate binding site [chemical binding]; other site
596154009291	ATP binding site [chemical binding]; other site
596154009292	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154009293	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
596154009294	FAD binding site [chemical binding]; other site
596154009295	substrate binding site [chemical binding]; other site
596154009296	catalytic base [active]
596154009297	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
596154009298	Predicted transcriptional regulator [Transcription]; Region: COG3905
596154009299	Proline dehydrogenase; Region: Pro_dh; pfam01619
596154009300	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
596154009301	NAD(P) binding site [chemical binding]; other site
596154009302	catalytic residues [active]
596154009303	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
596154009304	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
596154009305	Na binding site [ion binding]; other site
596154009306	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
596154009307	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154009308	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154009309	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
596154009310	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
596154009311	2-isopropylmalate synthase; Validated; Region: PRK00915
596154009312	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
596154009313	active site
596154009314	catalytic residues [active]
596154009315	metal binding site [ion binding]; metal-binding site
596154009316	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
596154009317	2-isopropylmalate synthase; Validated; Region: PRK03739
596154009318	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
596154009319	active site
596154009320	catalytic residues [active]
596154009321	metal binding site [ion binding]; metal-binding site
596154009322	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
596154009323	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154009324	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154009325	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
596154009326	putative dimerization interface [polypeptide binding]; other site
596154009327	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
596154009328	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
596154009329	Zn binding site [ion binding]; other site
596154009330	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
596154009331	benzoate transport; Region: 2A0115; TIGR00895
596154009332	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154009333	putative substrate translocation pore; other site
596154009334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154009335	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
596154009336	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
596154009337	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
596154009338	maleylacetoacetate isomerase; Region: maiA; TIGR01262
596154009339	C-terminal domain interface [polypeptide binding]; other site
596154009340	GSH binding site (G-site) [chemical binding]; other site
596154009341	putative dimer interface [polypeptide binding]; other site
596154009342	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
596154009343	dimer interface [polypeptide binding]; other site
596154009344	N-terminal domain interface [polypeptide binding]; other site
596154009345	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
596154009346	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
596154009347	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
596154009348	ketol-acid reductoisomerase; Provisional; Region: PRK05479
596154009349	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
596154009350	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
596154009351	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
596154009352	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
596154009353	putative valine binding site [chemical binding]; other site
596154009354	dimer interface [polypeptide binding]; other site
596154009355	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
596154009356	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
596154009357	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
596154009358	PYR/PP interface [polypeptide binding]; other site
596154009359	dimer interface [polypeptide binding]; other site
596154009360	TPP binding site [chemical binding]; other site
596154009361	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
596154009362	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
596154009363	TPP-binding site [chemical binding]; other site
596154009364	dimer interface [polypeptide binding]; other site
596154009365	RNA polymerase factor sigma-70; Validated; Region: PRK09047
596154009366	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
596154009367	DNA binding residues [nucleotide binding]
596154009368	Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
596154009369	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
596154009370	RDD family; Region: RDD; pfam06271
596154009371	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
596154009372	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
596154009373	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
596154009374	Nitrogen regulatory protein P-II; Region: P-II; smart00938
596154009375	NAD synthetase; Provisional; Region: PRK13981
596154009376	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
596154009377	multimer interface [polypeptide binding]; other site
596154009378	active site
596154009379	catalytic triad [active]
596154009380	protein interface 1 [polypeptide binding]; other site
596154009381	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
596154009382	homodimer interface [polypeptide binding]; other site
596154009383	NAD binding pocket [chemical binding]; other site
596154009384	ATP binding pocket [chemical binding]; other site
596154009385	Mg binding site [ion binding]; other site
596154009386	active-site loop [active]
596154009387	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
596154009388	Protein of unknown function, DUF482; Region: DUF482; pfam04339
596154009389	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
596154009390	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
596154009391	dimerization interface [polypeptide binding]; other site
596154009392	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
596154009393	dimer interface [polypeptide binding]; other site
596154009394	putative CheW interface [polypeptide binding]; other site
596154009395	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
596154009396	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
596154009397	dimer interface [polypeptide binding]; other site
596154009398	substrate binding site [chemical binding]; other site
596154009399	metal binding sites [ion binding]; metal-binding site
596154009400	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
596154009401	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
596154009402	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
596154009403	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
596154009404	NAD(P) binding site [chemical binding]; other site
596154009405	catalytic residues [active]
596154009406	catalytic residues [active]
596154009407	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
596154009408	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
596154009409	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
596154009410	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
596154009411	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
596154009412	FeS/SAM binding site; other site
596154009413	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
596154009414	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
596154009415	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
596154009416	GTP binding site; other site
596154009417	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
596154009418	Coenzyme A binding pocket [chemical binding]; other site
596154009419	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
596154009420	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
596154009421	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
596154009422	dimer interface [polypeptide binding]; other site
596154009423	putative functional site; other site
596154009424	putative MPT binding site; other site
596154009425	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
596154009426	catalytic residues [active]
596154009427	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154009428	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
596154009429	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
596154009430	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
596154009431	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
596154009432	substrate binding pocket [chemical binding]; other site
596154009433	membrane-bound complex binding site; other site
596154009434	hinge residues; other site
596154009435	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
596154009436	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154009437	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
596154009438	dimerization interface [polypeptide binding]; other site
596154009439	substrate binding pocket [chemical binding]; other site
596154009440	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
596154009441	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
596154009442	aspartate aminotransferase; Provisional; Region: PRK05764
596154009443	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
596154009444	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154009445	homodimer interface [polypeptide binding]; other site
596154009446	catalytic residue [active]
596154009447	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
596154009448	RNA/DNA hybrid binding site [nucleotide binding]; other site
596154009449	active site
596154009450	Methyltransferase domain; Region: Methyltransf_11; pfam08241
596154009451	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
596154009452	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
596154009453	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
596154009454	N-acetyl-D-glucosamine binding site [chemical binding]; other site
596154009455	catalytic residue [active]
596154009456	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
596154009457	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
596154009458	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
596154009459	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
596154009460	active site
596154009461	DNA binding site [nucleotide binding]
596154009462	Int/Topo IB signature motif; other site
596154009463	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
596154009464	Helix-turn-helix domain; Region: HTH_39; pfam14090
596154009465	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
596154009466	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
596154009467	putative ATP binding site [chemical binding]; other site
596154009468	putative substrate interface [chemical binding]; other site
596154009469	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
596154009470	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
596154009471	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
596154009472	ligand binding site [chemical binding]; other site
596154009473	translocation protein TolB; Provisional; Region: tolB; PRK02889
596154009474	TolB amino-terminal domain; Region: TolB_N; pfam04052
596154009475	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
596154009476	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
596154009477	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
596154009478	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
596154009479	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
596154009480	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
596154009481	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154009482	Walker A/P-loop; other site
596154009483	ATP binding site [chemical binding]; other site
596154009484	Q-loop/lid; other site
596154009485	ABC transporter signature motif; other site
596154009486	Walker B; other site
596154009487	D-loop; other site
596154009488	H-loop/switch region; other site
596154009489	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
596154009490	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
596154009491	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
596154009492	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
596154009493	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
596154009494	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
596154009495	carboxyltransferase (CT) interaction site; other site
596154009496	biotinylation site [posttranslational modification]; other site
596154009497	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
596154009498	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
596154009499	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
596154009500	hypothetical protein; Provisional; Region: PRK05463
596154009501	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
596154009502	putative active site [active]
596154009503	benzoate transport; Region: 2A0115; TIGR00895
596154009504	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154009505	putative substrate translocation pore; other site
596154009506	Transcriptional regulators [Transcription]; Region: GntR; COG1802
596154009507	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154009508	DNA-binding site [nucleotide binding]; DNA binding site
596154009509	FCD domain; Region: FCD; pfam07729
596154009510	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
596154009511	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
596154009512	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
596154009513	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
596154009514	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
596154009515	active site
596154009516	PilZ domain; Region: PilZ; cl01260
596154009517	DNA polymerase III subunit delta'; Validated; Region: PRK06964
596154009518	DNA polymerase III subunit delta'; Validated; Region: PRK08485
596154009519	thymidylate kinase; Validated; Region: tmk; PRK00698
596154009520	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
596154009521	TMP-binding site; other site
596154009522	ATP-binding site [chemical binding]; other site
596154009523	YceG-like family; Region: YceG; pfam02618
596154009524	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
596154009525	dimerization interface [polypeptide binding]; other site
596154009526	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
596154009527	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
596154009528	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
596154009529	nucleoside/Zn binding site; other site
596154009530	dimer interface [polypeptide binding]; other site
596154009531	catalytic motif [active]
596154009532	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
596154009533	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154009534	ATP binding site [chemical binding]; other site
596154009535	Mg2+ binding site [ion binding]; other site
596154009536	G-X-G motif; other site
596154009537	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
596154009538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154009539	active site
596154009540	phosphorylation site [posttranslational modification]
596154009541	intermolecular recognition site; other site
596154009542	dimerization interface [polypeptide binding]; other site
596154009543	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
596154009544	DNA binding residues [nucleotide binding]
596154009545	dimerization interface [polypeptide binding]; other site
596154009546	Domain of unknown function (DUF336); Region: DUF336; cl01249
596154009547	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
596154009548	active site
596154009549	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
596154009550	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
596154009551	Coenzyme A binding pocket [chemical binding]; other site
596154009552	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
596154009553	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
596154009554	HDOD domain; Region: HDOD; pfam08668
596154009555	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154009556	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
596154009557	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154009558	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
596154009559	Amidohydrolase; Region: Amidohydro_2; pfam04909
596154009560	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154009561	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154009562	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154009563	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154009564	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
596154009565	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
596154009566	active site
596154009567	oxalacetate binding site [chemical binding]; other site
596154009568	citrylCoA binding site [chemical binding]; other site
596154009569	coenzyme A binding site [chemical binding]; other site
596154009570	catalytic triad [active]
596154009571	Transcriptional regulators [Transcription]; Region: PurR; COG1609
596154009572	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
596154009573	DNA binding site [nucleotide binding]
596154009574	domain linker motif; other site
596154009575	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_5; cd06281
596154009576	putative dimerization interface [polypeptide binding]; other site
596154009577	putative ligand binding site [chemical binding]; other site
596154009578	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154009579	acyl-CoA synthetase; Validated; Region: PRK06188
596154009580	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154009581	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
596154009582	acyl-activating enzyme (AAE) consensus motif; other site
596154009583	acyl-activating enzyme (AAE) consensus motif; other site
596154009584	putative AMP binding site [chemical binding]; other site
596154009585	putative active site [active]
596154009586	putative CoA binding site [chemical binding]; other site
596154009587	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
596154009588	classical (c) SDRs; Region: SDR_c; cd05233
596154009589	NAD(P) binding site [chemical binding]; other site
596154009590	active site
596154009591	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154009592	acetyl-CoA acetyltransferase; Provisional; Region: PRK08142
596154009593	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
596154009594	active site
596154009595	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
596154009596	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
596154009597	DUF35 OB-fold domain; Region: DUF35; pfam01796
596154009598	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154009599	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
596154009600	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
596154009601	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
596154009602	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
596154009603	RNA binding site [nucleotide binding]; other site
596154009604	Protein of unknown function DUF72; Region: DUF72; pfam01904
596154009605	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
596154009606	ligand binding site [chemical binding]; other site
596154009607	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
596154009608	putative active site pocket [active]
596154009609	dimerization interface [polypeptide binding]; other site
596154009610	putative catalytic residue [active]
596154009611	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
596154009612	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
596154009613	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
596154009614	Membrane transport protein; Region: Mem_trans; cl09117
596154009615	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
596154009616	Chromate transporter; Region: Chromate_transp; pfam02417
596154009617	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
596154009618	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
596154009619	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
596154009620	methionine sulfoxide reductase A; Provisional; Region: PRK14054
596154009621	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154009622	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154009623	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
596154009624	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154009625	S-adenosylmethionine binding site [chemical binding]; other site
596154009626	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
596154009627	active site residue [active]
596154009628	Outer membrane efflux protein; Region: OEP; pfam02321
596154009629	Outer membrane efflux protein; Region: OEP; pfam02321
596154009630	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
596154009631	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
596154009632	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
596154009633	active site
596154009634	DNA binding site [nucleotide binding]
596154009635	Int/Topo IB signature motif; other site
596154009636	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
596154009637	EamA-like transporter family; Region: EamA; pfam00892
596154009638	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
596154009639	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
596154009640	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
596154009641	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154009642	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154009643	active site
596154009644	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
596154009645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154009646	dimer interface [polypeptide binding]; other site
596154009647	conserved gate region; other site
596154009648	putative PBP binding loops; other site
596154009649	ABC-ATPase subunit interface; other site
596154009650	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154009651	dimer interface [polypeptide binding]; other site
596154009652	conserved gate region; other site
596154009653	putative PBP binding loops; other site
596154009654	ABC-ATPase subunit interface; other site
596154009655	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
596154009656	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
596154009657	substrate binding pocket [chemical binding]; other site
596154009658	membrane-bound complex binding site; other site
596154009659	hinge residues; other site
596154009660	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
596154009661	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
596154009662	dimer interface [polypeptide binding]; other site
596154009663	active site
596154009664	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154009665	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
596154009666	substrate binding site [chemical binding]; other site
596154009667	oxyanion hole (OAH) forming residues; other site
596154009668	trimer interface [polypeptide binding]; other site
596154009669	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
596154009670	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
596154009671	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
596154009672	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
596154009673	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
596154009674	Walker A/P-loop; other site
596154009675	ATP binding site [chemical binding]; other site
596154009676	Q-loop/lid; other site
596154009677	ABC transporter signature motif; other site
596154009678	Walker B; other site
596154009679	D-loop; other site
596154009680	H-loop/switch region; other site
596154009681	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
596154009682	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
596154009683	Walker A/P-loop; other site
596154009684	ATP binding site [chemical binding]; other site
596154009685	Q-loop/lid; other site
596154009686	ABC transporter signature motif; other site
596154009687	Walker B; other site
596154009688	D-loop; other site
596154009689	H-loop/switch region; other site
596154009690	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
596154009691	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
596154009692	TM-ABC transporter signature motif; other site
596154009693	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
596154009694	TM-ABC transporter signature motif; other site
596154009695	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154009696	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
596154009697	putative ligand binding site [chemical binding]; other site
596154009698	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
596154009699	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
596154009700	dimer interface [polypeptide binding]; other site
596154009701	acyl-activating enzyme (AAE) consensus motif; other site
596154009702	putative active site [active]
596154009703	AMP binding site [chemical binding]; other site
596154009704	putative CoA binding site [chemical binding]; other site
596154009705	Uncharacterized conserved protein [Function unknown]; Region: COG0397
596154009706	hypothetical protein; Validated; Region: PRK00029
596154009707	methionine sulfoxide reductase B; Provisional; Region: PRK00222
596154009708	SelR domain; Region: SelR; pfam01641
596154009709	intracellular septation protein A; Reviewed; Region: PRK00259
596154009710	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
596154009711	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002
596154009712	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
596154009713	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
596154009714	tetratricopeptide repeat protein; Provisional; Region: PRK11788
596154009715	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
596154009716	binding surface
596154009717	TPR motif; other site
596154009718	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
596154009719	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
596154009720	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
596154009721	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
596154009722	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
596154009723	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
596154009724	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
596154009725	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
596154009726	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
596154009727	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
596154009728	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
596154009729	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
596154009730	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671
596154009731	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_5; cd06232
596154009732	putative active site [active]
596154009733	Zn binding site [ion binding]; other site
596154009734	chromosome condensation membrane protein; Provisional; Region: PRK14196
596154009735	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
596154009736	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154009737	putative substrate translocation pore; other site
596154009738	Major Facilitator Superfamily; Region: MFS_1; pfam07690
596154009739	RmuC family; Region: RmuC; pfam02646
596154009740	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
596154009741	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
596154009742	dimerization interface [polypeptide binding]; other site
596154009743	ligand binding site [chemical binding]; other site
596154009744	NADP binding site [chemical binding]; other site
596154009745	catalytic site [active]
596154009746	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
596154009747	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
596154009748	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
596154009749	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
596154009750	active site
596154009751	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
596154009752	active site
596154009753	Phasin protein; Region: Phasin_2; pfam09361
596154009754	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
596154009755	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
596154009756	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
596154009757	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
596154009758	NAD binding site [chemical binding]; other site
596154009759	homodimer interface [polypeptide binding]; other site
596154009760	homotetramer interface [polypeptide binding]; other site
596154009761	active site
596154009762	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
596154009763	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
596154009764	active site
596154009765	Int/Topo IB signature motif; other site
596154009766	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
596154009767	PRTRC system protein D; Region: PRTRC_D; TIGR03739
596154009768	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
596154009769	Mg binding site [ion binding]; other site
596154009770	nucleotide binding site [chemical binding]; other site
596154009771	putative protofilament interface [polypeptide binding]; other site
596154009772	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
596154009773	Integrase; Region: Integrase_1; pfam12835
596154009774	H-NS histone family; Region: Histone_HNS; pfam00816
596154009775	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
596154009776	PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736
596154009777	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
596154009778	ATP binding site [chemical binding]; other site
596154009779	Domain of unknown function (DUF2016); Region: DUF2016; pfam09436
596154009780	PRTRC system protein A; Region: PRTRC_A; TIGR03735
596154009781	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
596154009782	PRTRC system protein B; Region: PRTRC_B; TIGR03737
596154009783	PRTRC system protein F; Region: PRTRC_F; TIGR03742
596154009784	Alpha-helical domain 2; Region: alpha-hel2; pfam14456
596154009785	PRTRC system protein C; Region: PRTRC_C; TIGR03738
596154009786	PRTRC system protein E; Region: PRTRC_E; TIGR03741
596154009787	ParB-like nuclease domain; Region: ParB; smart00470
596154009788	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
596154009789	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
596154009790	IHF dimer interface [polypeptide binding]; other site
596154009791	IHF - DNA interface [nucleotide binding]; other site
596154009792	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
596154009793	AAA domain; Region: AAA_21; pfam13304
596154009794	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
596154009795	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
596154009796	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
596154009797	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154009798	S-adenosylmethionine binding site [chemical binding]; other site
596154009799	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
596154009800	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
596154009801	DEAD-like helicases superfamily; Region: DEXDc; smart00487
596154009802	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
596154009803	helicase superfamily c-terminal domain; Region: HELICc; smart00490
596154009804	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
596154009805	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154009806	Walker A/P-loop; other site
596154009807	ATP binding site [chemical binding]; other site
596154009808	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154009809	ABC transporter signature motif; other site
596154009810	Walker B; other site
596154009811	D-loop; other site
596154009812	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
596154009813	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
596154009814	active site
596154009815	metal binding site [ion binding]; metal-binding site
596154009816	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
596154009817	active site
596154009818	catalytic residues [active]
596154009819	Int/Topo IB signature motif; other site
596154009820	DNA binding site [nucleotide binding]
596154009821	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
596154009822	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
596154009823	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
596154009824	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
596154009825	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
596154009826	active site
596154009827	metal binding site [ion binding]; metal-binding site
596154009828	interdomain interaction site; other site
596154009829	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
596154009830	Predicted transcriptional regulator [Transcription]; Region: COG2932
596154009831	Catalytic site [active]
596154009832	Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036
596154009833	Putative helicase; Region: TraI_2; pfam07514
596154009834	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
596154009835	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
596154009836	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
596154009837	Domain of unknown function (DUF4400); Region: DUF4400; cl14023
596154009838	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154009839	sequence-specific DNA binding site [nucleotide binding]; other site
596154009840	salt bridge; other site
596154009841	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
596154009842	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
596154009843	N-acetyl-D-glucosamine binding site [chemical binding]; other site
596154009844	catalytic residue [active]
596154009845	TraL protein; Region: TraL; pfam07178
596154009846	TraE protein; Region: TraE; cl05060
596154009847	TraK protein; Region: TraK; pfam06586
596154009848	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
596154009849	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
596154009850	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
596154009851	dimerization domain [polypeptide binding]; other site
596154009852	dimer interface [polypeptide binding]; other site
596154009853	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
596154009854	catalytic residues [active]
596154009855	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
596154009856	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
596154009857	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
596154009858	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
596154009859	Walker A motif; other site
596154009860	ATP binding site [chemical binding]; other site
596154009861	conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771
596154009862	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
596154009863	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
596154009864	TraU protein; Region: TraU; pfam06834
596154009865	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673
596154009866	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
596154009867	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
596154009868	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
596154009869	F plasmid transfer operon protein; Region: TraF; pfam13728
596154009870	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
596154009871	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
596154009872	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
596154009873	active site
596154009874	catalytic residues [active]
596154009875	Int/Topo IB signature motif; other site
596154009876	DNA binding site [nucleotide binding]
596154009877	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
596154009878	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
596154009879	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
596154009880	Transposase; Region: HTH_Tnp_1; pfam01527
596154009881	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
596154009882	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
596154009883	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
596154009884	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
596154009885	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
596154009886	motif II; other site
596154009887	LemA family; Region: LemA; pfam04011
596154009888	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
596154009889	Repair protein; Region: Repair_PSII; pfam04536
596154009890	Repair protein; Region: Repair_PSII; pfam04536
596154009891	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
596154009892	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
596154009893	Beta-Casp domain; Region: Beta-Casp; smart01027
596154009894	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
596154009895	thymidine phosphorylase; Provisional; Region: PRK04350
596154009896	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
596154009897	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
596154009898	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
596154009899	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
596154009900	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
596154009901	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
596154009902	active site
596154009903	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
596154009904	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
596154009905	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
596154009906	nucleotide binding site [chemical binding]; other site
596154009907	putative mercuric reductase; Provisional; Region: PRK13748
596154009908	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
596154009909	metal-binding site [ion binding]
596154009910	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
596154009911	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
596154009912	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
596154009913	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
596154009914	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
596154009915	metal-binding site [ion binding]
596154009916	putative mercuric transport protein; Provisional; Region: PRK13751
596154009917	putative transcriptional regulator MerR; Provisional; Region: PRK13752
596154009918	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
596154009919	DNA binding residues [nucleotide binding]
596154009920	dimer interface [polypeptide binding]; other site
596154009921	mercury binding site [ion binding]; other site
596154009922	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
596154009923	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
596154009924	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
596154009925	Transposase; Region: HTH_Tnp_1; pfam01527
596154009926	putative transposase OrfB; Reviewed; Region: PHA02517
596154009927	HTH-like domain; Region: HTH_21; pfam13276
596154009928	Integrase core domain; Region: rve; pfam00665
596154009929	Integrase core domain; Region: rve_2; pfam13333
596154009930	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
596154009931	dimerization interface [polypeptide binding]; other site
596154009932	putative DNA binding site [nucleotide binding]; other site
596154009933	putative Zn2+ binding site [ion binding]; other site
596154009934	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
596154009935	active site residue [active]
596154009936	Methyltransferase domain; Region: Methyltransf_23; pfam13489
596154009937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154009938	S-adenosylmethionine binding site [chemical binding]; other site
596154009939	DsrE/DsrF-like family; Region: DrsE; cl00672
596154009940	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154009941	S-adenosylmethionine binding site [chemical binding]; other site
596154009942	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
596154009943	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
596154009944	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
596154009945	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154009946	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
596154009947	Nitrogen regulatory protein P-II; Region: P-II; smart00938
596154009948	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
596154009949	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
596154009950	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
596154009951	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
596154009952	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
596154009953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154009954	active site
596154009955	phosphorylation site [posttranslational modification]
596154009956	intermolecular recognition site; other site
596154009957	dimerization interface [polypeptide binding]; other site
596154009958	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
596154009959	DNA binding site [nucleotide binding]
596154009960	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
596154009961	HAMP domain; Region: HAMP; pfam00672
596154009962	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154009963	dimer interface [polypeptide binding]; other site
596154009964	phosphorylation site [posttranslational modification]
596154009965	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154009966	ATP binding site [chemical binding]; other site
596154009967	Mg2+ binding site [ion binding]; other site
596154009968	G-X-G motif; other site
596154009969	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
596154009970	EamA-like transporter family; Region: EamA; pfam00892
596154009971	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
596154009972	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
596154009973	Winged helix-turn helix; Region: HTH_29; pfam13551
596154009974	Homeodomain-like domain; Region: HTH_23; pfam13384
596154009975	Homeodomain-like domain; Region: HTH_32; pfam13565
596154009976	DDE superfamily endonuclease; Region: DDE_3; pfam13358
596154009977	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
596154009978	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
596154009979	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
596154009980	active site
596154009981	HIGH motif; other site
596154009982	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
596154009983	active site
596154009984	KMSKS motif; other site
596154009985	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
596154009986	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
596154009987	homodimer interface [polypeptide binding]; other site
596154009988	substrate-cofactor binding pocket; other site
596154009989	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154009990	catalytic residue [active]
596154009991	amidophosphoribosyltransferase; Provisional; Region: PRK09246
596154009992	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
596154009993	active site
596154009994	tetramer interface [polypeptide binding]; other site
596154009995	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
596154009996	active site
596154009997	Colicin V production protein; Region: Colicin_V; pfam02674
596154009998	Sporulation related domain; Region: SPOR; pfam05036
596154009999	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
596154010000	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
596154010001	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
596154010002	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
596154010003	ArsC family; Region: ArsC; pfam03960
596154010004	putative catalytic residues [active]
596154010005	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
596154010006	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
596154010007	argininosuccinate synthase; Validated; Region: PRK05370
596154010008	argininosuccinate synthase; Provisional; Region: PRK13820
596154010009	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
596154010010	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154010011	Walker A motif; other site
596154010012	ATP binding site [chemical binding]; other site
596154010013	Walker B motif; other site
596154010014	arginine finger; other site
596154010015	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
596154010016	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
596154010017	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
596154010018	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
596154010019	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
596154010020	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
596154010021	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
596154010022	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
596154010023	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
596154010024	Ligand Binding Site [chemical binding]; other site
596154010025	hypothetical protein; Provisional; Region: PRK11212
596154010026	SPW repeat; Region: SPW; pfam03779
596154010027	SPW repeat; Region: SPW; pfam03779
596154010028	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
596154010029	FAD binding domain; Region: FAD_binding_4; pfam01565
596154010030	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
596154010031	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
596154010032	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
596154010033	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
596154010034	catalytic motif [active]
596154010035	Catalytic residue [active]
596154010036	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
596154010037	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
596154010038	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
596154010039	putative deacylase active site [active]
596154010040	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
596154010041	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
596154010042	active site
596154010043	catalytic tetrad [active]
596154010044	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
596154010045	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154010046	Walker A/P-loop; other site
596154010047	ATP binding site [chemical binding]; other site
596154010048	Q-loop/lid; other site
596154010049	ABC transporter signature motif; other site
596154010050	Walker B; other site
596154010051	D-loop; other site
596154010052	H-loop/switch region; other site
596154010053	TOBE domain; Region: TOBE_2; pfam08402
596154010054	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
596154010055	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154010056	dimer interface [polypeptide binding]; other site
596154010057	conserved gate region; other site
596154010058	putative PBP binding loops; other site
596154010059	ABC-ATPase subunit interface; other site
596154010060	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154010061	dimer interface [polypeptide binding]; other site
596154010062	conserved gate region; other site
596154010063	putative PBP binding loops; other site
596154010064	ABC-ATPase subunit interface; other site
596154010065	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
596154010066	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
596154010067	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
596154010068	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
596154010069	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
596154010070	NAD binding site [chemical binding]; other site
596154010071	peptide chain release factor 2; Validated; Region: prfB; PRK00578
596154010072	This domain is found in peptide chain release factors; Region: PCRF; smart00937
596154010073	RF-1 domain; Region: RF-1; pfam00472
596154010074	aminopeptidase N; Provisional; Region: pepN; PRK14015
596154010075	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
596154010076	active site
596154010077	Zn binding site [ion binding]; other site
596154010078	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
596154010079	AMP binding site [chemical binding]; other site
596154010080	metal binding site [ion binding]; metal-binding site
596154010081	active site
596154010082	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
596154010083	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
596154010084	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
596154010085	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154010086	non-specific DNA binding site [nucleotide binding]; other site
596154010087	salt bridge; other site
596154010088	sequence-specific DNA binding site [nucleotide binding]; other site
596154010089	Terminase small subunit; Region: Terminase_2; cl01513
596154010090	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
596154010091	AAA domain; Region: AAA_25; pfam13481
596154010092	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
596154010093	Walker A motif; other site
596154010094	ATP binding site [chemical binding]; other site
596154010095	Walker B motif; other site
596154010096	Helix-turn-helix domain; Region: HTH_17; pfam12728
596154010097	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
596154010098	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
596154010099	active site
596154010100	DNA binding site [nucleotide binding]
596154010101	Int/Topo IB signature motif; other site
596154010102	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
596154010103	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
596154010104	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
596154010105	RNA/DNA hybrid binding site [nucleotide binding]; other site
596154010106	active site
596154010107	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
596154010108	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
596154010109	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
596154010110	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
596154010111	active site
596154010112	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
596154010113	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
596154010114	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
596154010115	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
596154010116	trimer interface [polypeptide binding]; other site
596154010117	active site
596154010118	UDP-GlcNAc binding site [chemical binding]; other site
596154010119	lipid binding site [chemical binding]; lipid-binding site
596154010120	periplasmic chaperone; Provisional; Region: PRK10780
596154010121	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
596154010122	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
596154010123	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
596154010124	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
596154010125	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
596154010126	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
596154010127	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
596154010128	Surface antigen; Region: Bac_surface_Ag; pfam01103
596154010129	zinc metallopeptidase RseP; Provisional; Region: PRK10779
596154010130	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
596154010131	active site
596154010132	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
596154010133	protein binding site [polypeptide binding]; other site
596154010134	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
596154010135	putative substrate binding region [chemical binding]; other site
596154010136	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
596154010137	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
596154010138	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
596154010139	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
596154010140	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
596154010141	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
596154010142	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
596154010143	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
596154010144	catalytic residue [active]
596154010145	putative FPP diphosphate  binding site; other site
596154010146	putative FPP binding hydrophobic cleft; other site
596154010147	dimer interface [polypeptide binding]; other site
596154010148	putative IPP diphosphate binding site; other site
596154010149	ribosome recycling factor; Reviewed; Region: frr; PRK00083
596154010150	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
596154010151	hinge region; other site
596154010152	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
596154010153	putative nucleotide binding site [chemical binding]; other site
596154010154	uridine monophosphate binding site [chemical binding]; other site
596154010155	homohexameric interface [polypeptide binding]; other site
596154010156	elongation factor Ts; Provisional; Region: tsf; PRK09377
596154010157	UBA/TS-N domain; Region: UBA; pfam00627
596154010158	Elongation factor TS; Region: EF_TS; pfam00889
596154010159	Elongation factor TS; Region: EF_TS; pfam00889
596154010160	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
596154010161	rRNA interaction site [nucleotide binding]; other site
596154010162	S8 interaction site; other site
596154010163	putative laminin-1 binding site; other site
596154010164	amidase; Provisional; Region: PRK07056
596154010165	Amidase; Region: Amidase; cl11426
596154010166	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
596154010167	hydroxyglutarate oxidase; Provisional; Region: PRK11728
596154010168	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
596154010169	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
596154010170	tetramer interface [polypeptide binding]; other site
596154010171	active site
596154010172	Mg2+/Mn2+ binding site [ion binding]; other site
596154010173	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
596154010174	mce related protein; Region: MCE; pfam02470
596154010175	Permease; Region: Permease; pfam02405
596154010176	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
596154010177	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
596154010178	DNA binding residues [nucleotide binding]
596154010179	dimer interface [polypeptide binding]; other site
596154010180	putative metal binding site [ion binding]; other site
596154010181	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
596154010182	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
596154010183	Soluble P-type ATPase [General function prediction only]; Region: COG4087
596154010184	Uncharacterized conserved protein [Function unknown]; Region: COG1284
596154010185	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
596154010186	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
596154010187	Predicted metal-binding protein [General function prediction only]; Region: COG3019
596154010188	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
596154010189	putative active site pocket [active]
596154010190	cleavage site
596154010191	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
596154010192	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
596154010193	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154010194	Walker A/P-loop; other site
596154010195	ATP binding site [chemical binding]; other site
596154010196	Q-loop/lid; other site
596154010197	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
596154010198	ABC transporter; Region: ABC_tran_2; pfam12848
596154010199	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
596154010200	helicase 45; Provisional; Region: PTZ00424
596154010201	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
596154010202	ATP binding site [chemical binding]; other site
596154010203	Mg++ binding site [ion binding]; other site
596154010204	motif III; other site
596154010205	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
596154010206	nucleotide binding region [chemical binding]; other site
596154010207	ATP-binding site [chemical binding]; other site
596154010208	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
596154010209	active site
596154010210	Zn binding site [ion binding]; other site
596154010211	LrgB-like family; Region: LrgB; cl00596
596154010212	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
596154010213	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154010214	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154010215	dimerization interface [polypeptide binding]; other site
596154010216	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
596154010217	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154010218	FAD binding site [chemical binding]; other site
596154010219	substrate binding pocket [chemical binding]; other site
596154010220	catalytic base [active]
596154010221	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154010222	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154010223	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154010224	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
596154010225	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
596154010226	putative NAD(P) binding site [chemical binding]; other site
596154010227	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
596154010228	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
596154010229	catalytic loop [active]
596154010230	iron binding site [ion binding]; other site
596154010231	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
596154010232	FAD binding pocket [chemical binding]; other site
596154010233	FAD binding motif [chemical binding]; other site
596154010234	phosphate binding motif [ion binding]; other site
596154010235	beta-alpha-beta structure motif; other site
596154010236	NAD binding pocket [chemical binding]; other site
596154010237	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
596154010238	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
596154010239	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
596154010240	catalytic residue [active]
596154010241	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154010242	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154010243	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
596154010244	putative dimerization interface [polypeptide binding]; other site
596154010245	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
596154010246	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154010247	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154010248	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
596154010249	putative active site [active]
596154010250	YdjC motif; other site
596154010251	Mg binding site [ion binding]; other site
596154010252	putative homodimer interface [polypeptide binding]; other site
596154010253	Predicted membrane protein [Function unknown]; Region: COG2246
596154010254	GtrA-like protein; Region: GtrA; pfam04138
596154010255	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
596154010256	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
596154010257	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
596154010258	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
596154010259	Ligand binding site; other site
596154010260	Putative Catalytic site; other site
596154010261	DXD motif; other site
596154010262	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
596154010263	catalytic center binding site [active]
596154010264	ATP binding site [chemical binding]; other site
596154010265	poly(A) polymerase; Region: pcnB; TIGR01942
596154010266	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
596154010267	active site
596154010268	NTP binding site [chemical binding]; other site
596154010269	metal binding triad [ion binding]; metal-binding site
596154010270	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
596154010271	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
596154010272	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
596154010273	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
596154010274	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
596154010275	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
596154010276	Walker A motif; other site
596154010277	ATP binding site [chemical binding]; other site
596154010278	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
596154010279	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
596154010280	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
596154010281	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
596154010282	dimerization interface [polypeptide binding]; other site
596154010283	putative ATP binding site [chemical binding]; other site
596154010284	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
596154010285	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
596154010286	Ligand Binding Site [chemical binding]; other site
596154010287	Uncharacterized conserved protein [Function unknown]; Region: COG2912
596154010288	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
596154010289	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
596154010290	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
596154010291	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
596154010292	Protein of unknown function DUF45; Region: DUF45; pfam01863
596154010293	archaeal ribosomal protein L6P; Region: arch_L6P; TIGR03653
596154010294	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
596154010295	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
596154010296	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
596154010297	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
596154010298	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
596154010299	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
596154010300	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
596154010301	Transposase; Region: HTH_Tnp_1; pfam01527
596154010302	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
596154010303	putative transposase OrfB; Reviewed; Region: PHA02517
596154010304	HTH-like domain; Region: HTH_21; pfam13276
596154010305	Integrase core domain; Region: rve; pfam00665
596154010306	Integrase core domain; Region: rve_3; cl15866
596154010307	Transposase; Region: HTH_Tnp_1; cl17663
596154010308	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
596154010309	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
596154010310	trimer interface [polypeptide binding]; other site
596154010311	eyelet of channel; other site
596154010312	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
596154010313	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154010314	Walker A motif; other site
596154010315	ATP binding site [chemical binding]; other site
596154010316	Walker B motif; other site
596154010317	arginine finger; other site
596154010318	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
596154010319	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154010320	non-specific DNA binding site [nucleotide binding]; other site
596154010321	salt bridge; other site
596154010322	sequence-specific DNA binding site [nucleotide binding]; other site
596154010323	Integrase core domain; Region: rve; pfam00665
596154010324	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
596154010325	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
596154010326	acetylornithine aminotransferase; Provisional; Region: PRK02627
596154010327	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
596154010328	inhibitor-cofactor binding pocket; inhibition site
596154010329	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154010330	catalytic residue [active]
596154010331	ornithine carbamoyltransferase; Provisional; Region: PRK00779
596154010332	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
596154010333	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
596154010334	Protein of unknown function, DUF488; Region: DUF488; pfam04343
596154010335	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
596154010336	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
596154010337	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
596154010338	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
596154010339	G1 box; other site
596154010340	GTP/Mg2+ binding site [chemical binding]; other site
596154010341	Switch I region; other site
596154010342	G2 box; other site
596154010343	G3 box; other site
596154010344	Switch II region; other site
596154010345	G4 box; other site
596154010346	G5 box; other site
596154010347	Nucleoside recognition; Region: Gate; pfam07670
596154010348	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
596154010349	Nucleoside recognition; Region: Gate; pfam07670
596154010350	FeoA domain; Region: FeoA; pfam04023
596154010351	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
596154010352	Putative cyclase; Region: Cyclase; cl00814
596154010353	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154010354	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154010355	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154010356	dimerization interface [polypeptide binding]; other site
596154010357	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
596154010358	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154010359	dimer interface [polypeptide binding]; other site
596154010360	conserved gate region; other site
596154010361	putative PBP binding loops; other site
596154010362	ABC-ATPase subunit interface; other site
596154010363	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
596154010364	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154010365	dimer interface [polypeptide binding]; other site
596154010366	conserved gate region; other site
596154010367	putative PBP binding loops; other site
596154010368	ABC-ATPase subunit interface; other site
596154010369	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
596154010370	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
596154010371	Walker A/P-loop; other site
596154010372	ATP binding site [chemical binding]; other site
596154010373	Q-loop/lid; other site
596154010374	ABC transporter signature motif; other site
596154010375	Walker B; other site
596154010376	D-loop; other site
596154010377	H-loop/switch region; other site
596154010378	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
596154010379	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
596154010380	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
596154010381	Walker A/P-loop; other site
596154010382	ATP binding site [chemical binding]; other site
596154010383	Q-loop/lid; other site
596154010384	ABC transporter signature motif; other site
596154010385	Walker B; other site
596154010386	D-loop; other site
596154010387	H-loop/switch region; other site
596154010388	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
596154010389	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
596154010390	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
596154010391	Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775
596154010392	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
596154010393	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
596154010394	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
596154010395	active site
596154010396	purine riboside binding site [chemical binding]; other site
596154010397	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
596154010398	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
596154010399	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154010400	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154010401	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
596154010402	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
596154010403	substrate binding pocket [chemical binding]; other site
596154010404	membrane-bound complex binding site; other site
596154010405	hinge residues; other site
596154010406	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
596154010407	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154010408	dimer interface [polypeptide binding]; other site
596154010409	conserved gate region; other site
596154010410	putative PBP binding loops; other site
596154010411	ABC-ATPase subunit interface; other site
596154010412	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
596154010413	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
596154010414	Walker A/P-loop; other site
596154010415	ATP binding site [chemical binding]; other site
596154010416	Q-loop/lid; other site
596154010417	ABC transporter signature motif; other site
596154010418	Walker B; other site
596154010419	D-loop; other site
596154010420	H-loop/switch region; other site
596154010421	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
596154010422	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
596154010423	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
596154010424	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
596154010425	putative ligand binding site [chemical binding]; other site
596154010426	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
596154010427	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
596154010428	putative ligand binding site [chemical binding]; other site
596154010429	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154010430	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
596154010431	TM-ABC transporter signature motif; other site
596154010432	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154010433	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
596154010434	TM-ABC transporter signature motif; other site
596154010435	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
596154010436	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
596154010437	Walker A/P-loop; other site
596154010438	ATP binding site [chemical binding]; other site
596154010439	Q-loop/lid; other site
596154010440	ABC transporter signature motif; other site
596154010441	Walker B; other site
596154010442	D-loop; other site
596154010443	H-loop/switch region; other site
596154010444	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
596154010445	Homeodomain-like domain; Region: HTH_23; pfam13384
596154010446	Winged helix-turn helix; Region: HTH_29; pfam13551
596154010447	DDE superfamily endonuclease; Region: DDE_3; pfam13358
596154010448	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
596154010449	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
596154010450	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
596154010451	ligand binding site [chemical binding]; other site
596154010452	flexible hinge region; other site
596154010453	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
596154010454	putative switch regulator; other site
596154010455	non-specific DNA interactions [nucleotide binding]; other site
596154010456	DNA binding site [nucleotide binding]
596154010457	sequence specific DNA binding site [nucleotide binding]; other site
596154010458	putative cAMP binding site [chemical binding]; other site
596154010459	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
596154010460	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
596154010461	trimer interface [polypeptide binding]; other site
596154010462	eyelet of channel; other site
596154010463	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
596154010464	HIT family signature motif; other site
596154010465	catalytic residue [active]
596154010466	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
596154010467	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
596154010468	putative ligand binding site [chemical binding]; other site
596154010469	NAD binding site [chemical binding]; other site
596154010470	catalytic site [active]
596154010471	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154010472	putative substrate translocation pore; other site
596154010473	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
596154010474	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
596154010475	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
596154010476	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
596154010477	Walker A/P-loop; other site
596154010478	ATP binding site [chemical binding]; other site
596154010479	Q-loop/lid; other site
596154010480	ABC transporter signature motif; other site
596154010481	Walker B; other site
596154010482	D-loop; other site
596154010483	H-loop/switch region; other site
596154010484	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
596154010485	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
596154010486	putative dimer interface [polypeptide binding]; other site
596154010487	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
596154010488	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
596154010489	FtsX-like permease family; Region: FtsX; pfam02687
596154010490	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
596154010491	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
596154010492	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
596154010493	catalytic residue [active]
596154010494	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
596154010495	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
596154010496	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
596154010497	TM-ABC transporter signature motif; other site
596154010498	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154010499	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
596154010500	TM-ABC transporter signature motif; other site
596154010501	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154010502	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
596154010503	putative ligand binding site [chemical binding]; other site
596154010504	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154010505	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
596154010506	putative ligand binding site [chemical binding]; other site
596154010507	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
596154010508	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
596154010509	Walker A/P-loop; other site
596154010510	ATP binding site [chemical binding]; other site
596154010511	Q-loop/lid; other site
596154010512	ABC transporter signature motif; other site
596154010513	Walker B; other site
596154010514	D-loop; other site
596154010515	H-loop/switch region; other site
596154010516	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
596154010517	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
596154010518	Walker A/P-loop; other site
596154010519	ATP binding site [chemical binding]; other site
596154010520	Q-loop/lid; other site
596154010521	ABC transporter signature motif; other site
596154010522	Walker B; other site
596154010523	D-loop; other site
596154010524	H-loop/switch region; other site
596154010525	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
596154010526	TOBE domain; Region: TOBE; cl01440
596154010527	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
596154010528	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
596154010529	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
596154010530	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154010531	putative PBP binding loops; other site
596154010532	dimer interface [polypeptide binding]; other site
596154010533	ABC-ATPase subunit interface; other site
596154010534	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154010535	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
596154010536	Walker A/P-loop; other site
596154010537	ATP binding site [chemical binding]; other site
596154010538	Q-loop/lid; other site
596154010539	ABC transporter signature motif; other site
596154010540	Walker B; other site
596154010541	D-loop; other site
596154010542	H-loop/switch region; other site
596154010543	TOBE domain; Region: TOBE; pfam03459
596154010544	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
596154010545	PBP superfamily domain; Region: PBP_like_2; pfam12849
596154010546	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
596154010547	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
596154010548	Walker A/P-loop; other site
596154010549	ATP binding site [chemical binding]; other site
596154010550	Q-loop/lid; other site
596154010551	ABC transporter signature motif; other site
596154010552	Walker B; other site
596154010553	D-loop; other site
596154010554	H-loop/switch region; other site
596154010555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
596154010556	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
596154010557	PBP superfamily domain; Region: PBP_like; pfam12727
596154010558	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
596154010559	putative active site [active]
596154010560	catalytic site [active]
596154010561	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
596154010562	PLD-like domain; Region: PLDc_2; pfam13091
596154010563	putative active site [active]
596154010564	catalytic site [active]
596154010565	acyl-CoA synthetase; Validated; Region: PRK08162
596154010566	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
596154010567	acyl-activating enzyme (AAE) consensus motif; other site
596154010568	putative active site [active]
596154010569	AMP binding site [chemical binding]; other site
596154010570	putative CoA binding site [chemical binding]; other site
596154010571	DNA primase, catalytic core; Region: dnaG; TIGR01391
596154010572	CHC2 zinc finger; Region: zf-CHC2; pfam01807
596154010573	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
596154010574	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
596154010575	active site
596154010576	metal binding site [ion binding]; metal-binding site
596154010577	interdomain interaction site; other site
596154010578	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
596154010579	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
596154010580	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
596154010581	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
596154010582	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
596154010583	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
596154010584	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
596154010585	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
596154010586	DNA binding residues [nucleotide binding]
596154010587	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
596154010588	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
596154010589	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
596154010590	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
596154010591	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154010592	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154010593	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154010594	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
596154010595	active site
596154010596	catalytic residues [active]
596154010597	metal binding site [ion binding]; metal-binding site
596154010598	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154010599	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154010600	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154010601	dimerization interface [polypeptide binding]; other site
596154010602	Predicted transcriptional regulators [Transcription]; Region: COG1733
596154010603	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
596154010604	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
596154010605	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
596154010606	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
596154010607	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
596154010608	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
596154010609	FeS/SAM binding site; other site
596154010610	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
596154010611	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
596154010612	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
596154010613	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
596154010614	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
596154010615	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
596154010616	HD domain; Region: HD_4; pfam13328
596154010617	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
596154010618	synthetase active site [active]
596154010619	NTP binding site [chemical binding]; other site
596154010620	metal binding site [ion binding]; metal-binding site
596154010621	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
596154010622	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
596154010623	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
596154010624	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
596154010625	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
596154010626	NAD binding site [chemical binding]; other site
596154010627	homotetramer interface [polypeptide binding]; other site
596154010628	homodimer interface [polypeptide binding]; other site
596154010629	substrate binding site [chemical binding]; other site
596154010630	active site
596154010631	Protein of unknown function (DUF541); Region: SIMPL; cl01077
596154010632	osmolarity response regulator; Provisional; Region: ompR; PRK09468
596154010633	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154010634	active site
596154010635	phosphorylation site [posttranslational modification]
596154010636	intermolecular recognition site; other site
596154010637	dimerization interface [polypeptide binding]; other site
596154010638	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
596154010639	DNA binding site [nucleotide binding]
596154010640	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
596154010641	dimerization interface [polypeptide binding]; other site
596154010642	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154010643	dimer interface [polypeptide binding]; other site
596154010644	phosphorylation site [posttranslational modification]
596154010645	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154010646	ATP binding site [chemical binding]; other site
596154010647	Mg2+ binding site [ion binding]; other site
596154010648	G-X-G motif; other site
596154010649	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
596154010650	homotrimer interaction site [polypeptide binding]; other site
596154010651	zinc binding site [ion binding]; other site
596154010652	CDP-binding sites; other site
596154010653	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
596154010654	substrate binding site; other site
596154010655	dimer interface; other site
596154010656	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
596154010657	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
596154010658	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
596154010659	ATP binding site [chemical binding]; other site
596154010660	putative Mg++ binding site [ion binding]; other site
596154010661	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
596154010662	nucleotide binding region [chemical binding]; other site
596154010663	ATP-binding site [chemical binding]; other site
596154010664	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
596154010665	Predicted membrane protein [Function unknown]; Region: COG3235
596154010666	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
596154010667	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
596154010668	motif II; other site
596154010669	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
596154010670	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
596154010671	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
596154010672	motif II; other site
596154010673	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
596154010674	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154010675	active site
596154010676	phosphorylation site [posttranslational modification]
596154010677	intermolecular recognition site; other site
596154010678	dimerization interface [polypeptide binding]; other site
596154010679	LytTr DNA-binding domain; Region: LytTR; smart00850
596154010680	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
596154010681	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
596154010682	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
596154010683	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154010684	substrate binding site [chemical binding]; other site
596154010685	oxyanion hole (OAH) forming residues; other site
596154010686	trimer interface [polypeptide binding]; other site
596154010687	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154010688	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154010689	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154010690	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
596154010691	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154010692	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
596154010693	putative dimerization interface [polypeptide binding]; other site
596154010694	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
596154010695	Uncharacterized conserved protein [Function unknown]; Region: COG2128
596154010696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154010697	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
596154010698	classical (c) SDRs; Region: SDR_c; cd05233
596154010699	NAD(P) binding site [chemical binding]; other site
596154010700	active site
596154010701	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154010702	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154010703	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
596154010704	putative dimerization interface [polypeptide binding]; other site
596154010705	DNA polymerase I; Provisional; Region: PRK05755
596154010706	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
596154010707	active site
596154010708	metal binding site 1 [ion binding]; metal-binding site
596154010709	putative 5' ssDNA interaction site; other site
596154010710	metal binding site 3; metal-binding site
596154010711	metal binding site 2 [ion binding]; metal-binding site
596154010712	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
596154010713	putative DNA binding site [nucleotide binding]; other site
596154010714	putative metal binding site [ion binding]; other site
596154010715	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
596154010716	active site
596154010717	catalytic site [active]
596154010718	substrate binding site [chemical binding]; other site
596154010719	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
596154010720	active site
596154010721	DNA binding site [nucleotide binding]
596154010722	catalytic site [active]
596154010723	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
596154010724	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
596154010725	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
596154010726	putative active site [active]
596154010727	putative substrate binding site [chemical binding]; other site
596154010728	ATP binding site [chemical binding]; other site
596154010729	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
596154010730	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
596154010731	substrate binding pocket [chemical binding]; other site
596154010732	membrane-bound complex binding site; other site
596154010733	hinge residues; other site
596154010734	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154010735	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154010736	metal binding site [ion binding]; metal-binding site
596154010737	active site
596154010738	I-site; other site
596154010739	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
596154010740	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
596154010741	Part of AAA domain; Region: AAA_19; pfam13245
596154010742	AAA domain; Region: AAA_12; pfam13087
596154010743	Family description; Region: UvrD_C_2; pfam13538
596154010744	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
596154010745	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
596154010746	active site
596154010747	Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919
596154010748	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
596154010749	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
596154010750	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
596154010751	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
596154010752	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
596154010753	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
596154010754	N-terminal plug; other site
596154010755	ligand-binding site [chemical binding]; other site
596154010756	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
596154010757	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154010758	Walker A/P-loop; other site
596154010759	ATP binding site [chemical binding]; other site
596154010760	Q-loop/lid; other site
596154010761	ABC transporter signature motif; other site
596154010762	Walker B; other site
596154010763	D-loop; other site
596154010764	H-loop/switch region; other site
596154010765	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
596154010766	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
596154010767	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
596154010768	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
596154010769	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
596154010770	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
596154010771	ligand binding site [chemical binding]; other site
596154010772	flexible hinge region; other site
596154010773	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
596154010774	putative switch regulator; other site
596154010775	non-specific DNA interactions [nucleotide binding]; other site
596154010776	DNA binding site [nucleotide binding]
596154010777	sequence specific DNA binding site [nucleotide binding]; other site
596154010778	putative cAMP binding site [chemical binding]; other site
596154010779	Protein of unknown function (DUF461); Region: DUF461; pfam04314
596154010780	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154010781	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
596154010782	putative substrate translocation pore; other site
596154010783	YciI-like protein; Reviewed; Region: PRK12863
596154010784	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154010785	Coenzyme A transferase; Region: CoA_trans; cl17247
596154010786	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
596154010787	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
596154010788	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
596154010789	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154010790	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154010791	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
596154010792	putative dimerization interface [polypeptide binding]; other site
596154010793	PAS domain; Region: PAS_9; pfam13426
596154010794	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
596154010795	PAS domain; Region: PAS_9; pfam13426
596154010796	putative active site [active]
596154010797	heme pocket [chemical binding]; other site
596154010798	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154010799	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154010800	metal binding site [ion binding]; metal-binding site
596154010801	active site
596154010802	I-site; other site
596154010803	helicase 45; Provisional; Region: PTZ00424
596154010804	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
596154010805	ATP binding site [chemical binding]; other site
596154010806	Mg++ binding site [ion binding]; other site
596154010807	motif III; other site
596154010808	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
596154010809	nucleotide binding region [chemical binding]; other site
596154010810	ATP-binding site [chemical binding]; other site
596154010811	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
596154010812	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
596154010813	dimerization interface [polypeptide binding]; other site
596154010814	ligand binding site [chemical binding]; other site
596154010815	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
596154010816	catalytic site [active]
596154010817	putative active site [active]
596154010818	putative substrate binding site [chemical binding]; other site
596154010819	dimer interface [polypeptide binding]; other site
596154010820	Peptidase family M48; Region: Peptidase_M48; cl12018
596154010821	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
596154010822	aromatic arch; other site
596154010823	DCoH dimer interaction site [polypeptide binding]; other site
596154010824	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
596154010825	DCoH tetramer interaction site [polypeptide binding]; other site
596154010826	substrate binding site [chemical binding]; other site
596154010827	GTPase RsgA; Reviewed; Region: PRK00098
596154010828	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
596154010829	RNA binding site [nucleotide binding]; other site
596154010830	homodimer interface [polypeptide binding]; other site
596154010831	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
596154010832	GTPase/Zn-binding domain interface [polypeptide binding]; other site
596154010833	GTP/Mg2+ binding site [chemical binding]; other site
596154010834	G4 box; other site
596154010835	G5 box; other site
596154010836	G1 box; other site
596154010837	Switch I region; other site
596154010838	G2 box; other site
596154010839	G3 box; other site
596154010840	Switch II region; other site
596154010841	putative transporter; Provisional; Region: PRK11660
596154010842	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
596154010843	Sulfate transporter family; Region: Sulfate_transp; pfam00916
596154010844	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
596154010845	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
596154010846	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
596154010847	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154010848	homodimer interface [polypeptide binding]; other site
596154010849	catalytic residue [active]
596154010850	CobD/Cbib protein; Region: CobD_Cbib; cl00561
596154010851	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
596154010852	putative active site [active]
596154010853	putative CoA binding site [chemical binding]; other site
596154010854	nudix motif; other site
596154010855	metal binding site [ion binding]; metal-binding site
596154010856	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
596154010857	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
596154010858	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
596154010859	RimM N-terminal domain; Region: RimM; pfam01782
596154010860	PRC-barrel domain; Region: PRC; pfam05239
596154010861	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
596154010862	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
596154010863	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
596154010864	TM2 domain; Region: TM2; pfam05154
596154010865	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
596154010866	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
596154010867	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
596154010868	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3169
596154010869	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
596154010870	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
596154010871	Walker A/P-loop; other site
596154010872	ATP binding site [chemical binding]; other site
596154010873	Q-loop/lid; other site
596154010874	ABC transporter signature motif; other site
596154010875	Walker B; other site
596154010876	D-loop; other site
596154010877	H-loop/switch region; other site
596154010878	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
596154010879	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
596154010880	Walker A/P-loop; other site
596154010881	ATP binding site [chemical binding]; other site
596154010882	Q-loop/lid; other site
596154010883	ABC transporter signature motif; other site
596154010884	Walker B; other site
596154010885	D-loop; other site
596154010886	H-loop/switch region; other site
596154010887	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
596154010888	TM-ABC transporter signature motif; other site
596154010889	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154010890	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
596154010891	TM-ABC transporter signature motif; other site
596154010892	recombination factor protein RarA; Reviewed; Region: PRK13342
596154010893	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154010894	Walker A motif; other site
596154010895	ATP binding site [chemical binding]; other site
596154010896	Walker B motif; other site
596154010897	arginine finger; other site
596154010898	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
596154010899	integron integrase; Region: integrase_gron; TIGR02249
596154010900	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
596154010901	Int/Topo IB signature motif; other site
596154010902	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
596154010903	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
596154010904	protein binding site [polypeptide binding]; other site
596154010905	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
596154010906	active site
596154010907	Protein of unknown function (DUF1010); Region: DUF1010; pfam06231
596154010908	PIN domain; Region: PIN; pfam01850
596154010909	topology modulation protein; Provisional; Region: PRK07261
596154010910	AAA domain; Region: AAA_17; pfam13207
596154010911	putative transposase OrfB; Reviewed; Region: PHA02517
596154010912	HTH-like domain; Region: HTH_21; pfam13276
596154010913	Integrase core domain; Region: rve; pfam00665
596154010914	Integrase core domain; Region: rve_3; pfam13683
596154010915	Transposase; Region: HTH_Tnp_1; pfam01527
596154010916	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
596154010917	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
596154010918	ligand binding site [chemical binding]; other site
596154010919	active site
596154010920	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
596154010921	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
596154010922	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
596154010923	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
596154010924	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
596154010925	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
596154010926	thioredoxin reductase; Provisional; Region: PRK10262
596154010927	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
596154010928	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
596154010929	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
596154010930	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
596154010931	16S rRNA methyltransferase B; Provisional; Region: PRK14901
596154010932	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154010933	S-adenosylmethionine binding site [chemical binding]; other site
596154010934	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
596154010935	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
596154010936	active site
596154010937	substrate binding site [chemical binding]; other site
596154010938	cosubstrate binding site; other site
596154010939	catalytic site [active]
596154010940	Protein of unknown function, DUF480; Region: DUF480; pfam04337
596154010941	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
596154010942	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154010943	active site
596154010944	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
596154010945	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
596154010946	active site
596154010947	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
596154010948	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
596154010949	active site
596154010950	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
596154010951	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
596154010952	active site
596154010953	Riboflavin kinase; Region: Flavokinase; smart00904
596154010954	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
596154010955	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
596154010956	active site
596154010957	HIGH motif; other site
596154010958	nucleotide binding site [chemical binding]; other site
596154010959	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
596154010960	active site
596154010961	KMSKS motif; other site
596154010962	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
596154010963	tRNA binding surface [nucleotide binding]; other site
596154010964	anticodon binding site; other site
596154010965	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
596154010966	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
596154010967	Transcriptional regulators [Transcription]; Region: PurR; COG1609
596154010968	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
596154010969	DNA binding site [nucleotide binding]
596154010970	domain linker motif; other site
596154010971	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
596154010972	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
596154010973	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
596154010974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154010975	dimer interface [polypeptide binding]; other site
596154010976	conserved gate region; other site
596154010977	putative PBP binding loops; other site
596154010978	ABC-ATPase subunit interface; other site
596154010979	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
596154010980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154010981	dimer interface [polypeptide binding]; other site
596154010982	conserved gate region; other site
596154010983	putative PBP binding loops; other site
596154010984	ABC-ATPase subunit interface; other site
596154010985	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
596154010986	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154010987	Walker A/P-loop; other site
596154010988	ATP binding site [chemical binding]; other site
596154010989	Q-loop/lid; other site
596154010990	ABC transporter signature motif; other site
596154010991	Walker B; other site
596154010992	D-loop; other site
596154010993	H-loop/switch region; other site
596154010994	TOBE domain; Region: TOBE_2; pfam08402
596154010995	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
596154010996	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
596154010997	active site
596154010998	metal binding site [ion binding]; metal-binding site
596154010999	hexamer interface [polypeptide binding]; other site
596154011000	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
596154011001	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
596154011002	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
596154011003	PhoU domain; Region: PhoU; pfam01895
596154011004	PhoU domain; Region: PhoU; pfam01895
596154011005	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
596154011006	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
596154011007	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154011008	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154011009	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
596154011010	putative dimerization interface [polypeptide binding]; other site
596154011011	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
596154011012	nudix motif; other site
596154011013	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
596154011014	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
596154011015	NADP binding site [chemical binding]; other site
596154011016	dimer interface [polypeptide binding]; other site
596154011017	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
596154011018	EamA-like transporter family; Region: EamA; pfam00892
596154011019	EamA-like transporter family; Region: EamA; pfam00892
596154011020	PAS fold; Region: PAS_7; pfam12860
596154011021	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154011022	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154011023	metal binding site [ion binding]; metal-binding site
596154011024	active site
596154011025	I-site; other site
596154011026	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
596154011027	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
596154011028	short chain dehydrogenase; Provisional; Region: PRK08339
596154011029	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
596154011030	putative NAD(P) binding site [chemical binding]; other site
596154011031	putative active site [active]
596154011032	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
596154011033	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
596154011034	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
596154011035	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
596154011036	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
596154011037	Walker A motif; other site
596154011038	ATP binding site [chemical binding]; other site
596154011039	Walker B motif; other site
596154011040	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
596154011041	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
596154011042	putative active site [active]
596154011043	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
596154011044	active site
596154011045	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
596154011046	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
596154011047	dimerization interface [polypeptide binding]; other site
596154011048	putative DNA binding site [nucleotide binding]; other site
596154011049	putative Zn2+ binding site [ion binding]; other site
596154011050	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
596154011051	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
596154011052	MoxR-like ATPases [General function prediction only]; Region: COG0714
596154011053	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154011054	Walker A motif; other site
596154011055	ATP binding site [chemical binding]; other site
596154011056	Walker B motif; other site
596154011057	arginine finger; other site
596154011058	Protein of unknown function DUF58; Region: DUF58; pfam01882
596154011059	von Willebrand factor type A domain; Region: VWA_2; pfam13519
596154011060	metal ion-dependent adhesion site (MIDAS); other site
596154011061	acetyl-CoA synthetase; Provisional; Region: PRK00174
596154011062	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
596154011063	active site
596154011064	CoA binding site [chemical binding]; other site
596154011065	acyl-activating enzyme (AAE) consensus motif; other site
596154011066	AMP binding site [chemical binding]; other site
596154011067	acetate binding site [chemical binding]; other site
596154011068	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
596154011069	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
596154011070	Walker A/P-loop; other site
596154011071	ATP binding site [chemical binding]; other site
596154011072	Q-loop/lid; other site
596154011073	ABC transporter signature motif; other site
596154011074	Walker B; other site
596154011075	D-loop; other site
596154011076	H-loop/switch region; other site
596154011077	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
596154011078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154011079	dimer interface [polypeptide binding]; other site
596154011080	conserved gate region; other site
596154011081	putative PBP binding loops; other site
596154011082	ABC-ATPase subunit interface; other site
596154011083	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
596154011084	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
596154011085	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
596154011086	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
596154011087	ligand binding site [chemical binding]; other site
596154011088	flexible hinge region; other site
596154011089	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
596154011090	non-specific DNA interactions [nucleotide binding]; other site
596154011091	DNA binding site [nucleotide binding]
596154011092	sequence specific DNA binding site [nucleotide binding]; other site
596154011093	putative cAMP binding site [chemical binding]; other site
596154011094	fumarate hydratase; Reviewed; Region: fumC; PRK00485
596154011095	Class II fumarases; Region: Fumarase_classII; cd01362
596154011096	active site
596154011097	tetramer interface [polypeptide binding]; other site
596154011098	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
596154011099	Fumarase C-terminus; Region: Fumerase_C; pfam05683
596154011100	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
596154011101	peptidase PmbA; Provisional; Region: PRK11040
596154011102	Protein of unknown function (DUF615); Region: DUF615; pfam04751
596154011103	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
596154011104	MPT binding site; other site
596154011105	trimer interface [polypeptide binding]; other site
596154011106	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
596154011107	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
596154011108	tetramer interface [polypeptide binding]; other site
596154011109	catalytic Zn binding site [ion binding]; other site
596154011110	NADP binding site [chemical binding]; other site
596154011111	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
596154011112	putative FMN binding site [chemical binding]; other site
596154011113	serine O-acetyltransferase; Region: cysE; TIGR01172
596154011114	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
596154011115	trimer interface [polypeptide binding]; other site
596154011116	active site
596154011117	substrate binding site [chemical binding]; other site
596154011118	CoA binding site [chemical binding]; other site
596154011119	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
596154011120	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
596154011121	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
596154011122	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
596154011123	active site
596154011124	dimerization interface [polypeptide binding]; other site
596154011125	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
596154011126	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
596154011127	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
596154011128	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
596154011129	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
596154011130	ATP binding site [chemical binding]; other site
596154011131	putative Mg++ binding site [ion binding]; other site
596154011132	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
596154011133	nucleotide binding region [chemical binding]; other site
596154011134	ATP-binding site [chemical binding]; other site
596154011135	DEAD/H associated; Region: DEAD_assoc; pfam08494
596154011136	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
596154011137	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
596154011138	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
596154011139	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
596154011140	TPP-binding site; other site
596154011141	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
596154011142	PYR/PP interface [polypeptide binding]; other site
596154011143	dimer interface [polypeptide binding]; other site
596154011144	TPP binding site [chemical binding]; other site
596154011145	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
596154011146	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
596154011147	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
596154011148	substrate binding pocket [chemical binding]; other site
596154011149	chain length determination region; other site
596154011150	substrate-Mg2+ binding site; other site
596154011151	catalytic residues [active]
596154011152	aspartate-rich region 1; other site
596154011153	active site lid residues [active]
596154011154	aspartate-rich region 2; other site
596154011155	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
596154011156	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
596154011157	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
596154011158	[2Fe-2S] cluster binding site [ion binding]; other site
596154011159	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
596154011160	alpha subunit interface [polypeptide binding]; other site
596154011161	active site
596154011162	substrate binding site [chemical binding]; other site
596154011163	Fe binding site [ion binding]; other site
596154011164	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
596154011165	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
596154011166	active site residue [active]
596154011167	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
596154011168	active site residue [active]
596154011169	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
596154011170	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
596154011171	tetramerization interface [polypeptide binding]; other site
596154011172	NAD(P) binding site [chemical binding]; other site
596154011173	catalytic residues [active]
596154011174	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
596154011175	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
596154011176	Competence protein; Region: Competence; pfam03772
596154011177	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
596154011178	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
596154011179	homotrimer interaction site [polypeptide binding]; other site
596154011180	putative active site [active]
596154011181	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
596154011182	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
596154011183	CAP-like domain; other site
596154011184	active site
596154011185	primary dimer interface [polypeptide binding]; other site
596154011186	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
596154011187	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
596154011188	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154011189	ATP binding site [chemical binding]; other site
596154011190	Mg2+ binding site [ion binding]; other site
596154011191	G-X-G motif; other site
596154011192	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
596154011193	anchoring element; other site
596154011194	dimer interface [polypeptide binding]; other site
596154011195	ATP binding site [chemical binding]; other site
596154011196	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
596154011197	active site
596154011198	metal binding site [ion binding]; metal-binding site
596154011199	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
596154011200	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154011201	Major Facilitator Superfamily; Region: MFS_1; pfam07690
596154011202	putative substrate translocation pore; other site
596154011203	Methyltransferase domain; Region: Methyltransf_23; pfam13489
596154011204	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154011205	S-adenosylmethionine binding site [chemical binding]; other site
596154011206	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
596154011207	dihydrodipicolinate synthase; Region: dapA; TIGR00674
596154011208	dimer interface [polypeptide binding]; other site
596154011209	active site
596154011210	catalytic residue [active]
596154011211	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
596154011212	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
596154011213	Uncharacterized conserved protein [Function unknown]; Region: COG2850
596154011214	Cupin-like domain; Region: Cupin_8; pfam13621
596154011215	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
596154011216	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
596154011217	trimer interface [polypeptide binding]; other site
596154011218	active site
596154011219	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
596154011220	Flavoprotein; Region: Flavoprotein; pfam02441
596154011221	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
596154011222	CTP synthetase; Validated; Region: pyrG; PRK05380
596154011223	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
596154011224	Catalytic site [active]
596154011225	active site
596154011226	UTP binding site [chemical binding]; other site
596154011227	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
596154011228	active site
596154011229	putative oxyanion hole; other site
596154011230	catalytic triad [active]
596154011231	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
596154011232	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
596154011233	Uncharacterized conserved protein [Function unknown]; Region: COG5470
596154011234	enolase; Provisional; Region: eno; PRK00077
596154011235	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
596154011236	dimer interface [polypeptide binding]; other site
596154011237	metal binding site [ion binding]; metal-binding site
596154011238	substrate binding pocket [chemical binding]; other site
596154011239	Septum formation initiator; Region: DivIC; cl17659
596154011240	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
596154011241	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
596154011242	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
596154011243	Walker A/P-loop; other site
596154011244	ATP binding site [chemical binding]; other site
596154011245	Q-loop/lid; other site
596154011246	ABC transporter signature motif; other site
596154011247	Walker B; other site
596154011248	D-loop; other site
596154011249	H-loop/switch region; other site
596154011250	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154011251	dimer interface [polypeptide binding]; other site
596154011252	conserved gate region; other site
596154011253	putative PBP binding loops; other site
596154011254	ABC-ATPase subunit interface; other site
596154011255	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
596154011256	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154011257	dimer interface [polypeptide binding]; other site
596154011258	conserved gate region; other site
596154011259	putative PBP binding loops; other site
596154011260	ABC-ATPase subunit interface; other site
596154011261	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
596154011262	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
596154011263	substrate binding pocket [chemical binding]; other site
596154011264	membrane-bound complex binding site; other site
596154011265	hinge residues; other site
596154011266	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
596154011267	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
596154011268	dimerization interface [polypeptide binding]; other site
596154011269	domain crossover interface; other site
596154011270	redox-dependent activation switch; other site
596154011271	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
596154011272	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
596154011273	trimer interface [polypeptide binding]; other site
596154011274	putative metal binding site [ion binding]; other site
596154011275	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
596154011276	dinuclear metal binding motif [ion binding]; other site
596154011277	EAL domain; Region: EAL; pfam00563
596154011278	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
596154011279	EAL domain; Region: EAL; pfam00563
596154011280	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154011281	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154011282	PAS domain; Region: PAS_9; pfam13426
596154011283	putative active site [active]
596154011284	heme pocket [chemical binding]; other site
596154011285	Predicted transcriptional regulators [Transcription]; Region: COG1733
596154011286	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
596154011287	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
596154011288	active site
596154011289	putative DNA-binding cleft [nucleotide binding]; other site
596154011290	dimer interface [polypeptide binding]; other site
596154011291	Transposase; Region: HTH_Tnp_1; pfam01527
596154011292	putative transposase OrfB; Reviewed; Region: PHA02517
596154011293	Integrase core domain; Region: rve; pfam00665
596154011294	Integrase core domain; Region: rve_3; pfam13683
596154011295	Transglycosylase; Region: Transgly; cl17702
596154011296	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
596154011297	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
596154011298	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
596154011299	shikimate binding site; other site
596154011300	NAD(P) binding site [chemical binding]; other site
596154011301	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
596154011302	TonB C terminal; Region: TonB_2; pfam13103
596154011303	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
596154011304	RNB domain; Region: RNB; pfam00773
596154011305	RNA polymerase sigma factor; Provisional; Region: PRK11922
596154011306	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
596154011307	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
596154011308	DNA binding residues [nucleotide binding]
596154011309	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
596154011310	dinuclear metal binding motif [ion binding]; other site
596154011311	Cytochrome c; Region: Cytochrom_C; cl11414
596154011312	O-Antigen ligase; Region: Wzy_C; pfam04932
596154011313	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
596154011314	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
596154011315	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
596154011316	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
596154011317	protease TldD; Provisional; Region: tldD; PRK10735
596154011318	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
596154011319	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
596154011320	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
596154011321	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
596154011322	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
596154011323	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
596154011324	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
596154011325	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
596154011326	catalytic residues [active]
596154011327	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
596154011328	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
596154011329	carboxyltransferase (CT) interaction site; other site
596154011330	biotinylation site [posttranslational modification]; other site
596154011331	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
596154011332	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
596154011333	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
596154011334	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
596154011335	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
596154011336	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
596154011337	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
596154011338	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
596154011339	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
596154011340	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
596154011341	substrate binding site [chemical binding]; other site
596154011342	ATP binding site [chemical binding]; other site
596154011343	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
596154011344	dimer interface [polypeptide binding]; other site
596154011345	putative radical transfer pathway; other site
596154011346	diiron center [ion binding]; other site
596154011347	tyrosyl radical; other site
596154011348	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
596154011349	ATP cone domain; Region: ATP-cone; pfam03477
596154011350	Class I ribonucleotide reductase; Region: RNR_I; cd01679
596154011351	active site
596154011352	dimer interface [polypeptide binding]; other site
596154011353	catalytic residues [active]
596154011354	effector binding site; other site
596154011355	R2 peptide binding site; other site
596154011356	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
596154011357	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
596154011358	amidase catalytic site [active]
596154011359	Zn binding residues [ion binding]; other site
596154011360	substrate binding site [chemical binding]; other site
596154011361	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
596154011362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154011363	active site
596154011364	phosphorylation site [posttranslational modification]
596154011365	intermolecular recognition site; other site
596154011366	dimerization interface [polypeptide binding]; other site
596154011367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154011368	Walker A motif; other site
596154011369	ATP binding site [chemical binding]; other site
596154011370	Walker B motif; other site
596154011371	arginine finger; other site
596154011372	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
596154011373	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
596154011374	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154011375	dimer interface [polypeptide binding]; other site
596154011376	phosphorylation site [posttranslational modification]
596154011377	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154011378	ATP binding site [chemical binding]; other site
596154011379	Mg2+ binding site [ion binding]; other site
596154011380	G-X-G motif; other site
596154011381	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
596154011382	signal recognition particle protein; Provisional; Region: PRK10867
596154011383	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
596154011384	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
596154011385	GTP binding site [chemical binding]; other site
596154011386	Signal peptide binding domain; Region: SRP_SPB; pfam02978
596154011387	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
596154011388	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
596154011389	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
596154011390	FeS/SAM binding site; other site
596154011391	TRAM domain; Region: TRAM; pfam01938
596154011392	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
596154011393	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
596154011394	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
596154011395	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
596154011396	dimerization domain [polypeptide binding]; other site
596154011397	dimer interface [polypeptide binding]; other site
596154011398	catalytic residues [active]
596154011399	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
596154011400	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
596154011401	GTP-binding protein YchF; Reviewed; Region: PRK09601
596154011402	YchF GTPase; Region: YchF; cd01900
596154011403	G1 box; other site
596154011404	GTP/Mg2+ binding site [chemical binding]; other site
596154011405	Switch I region; other site
596154011406	G2 box; other site
596154011407	Switch II region; other site
596154011408	G3 box; other site
596154011409	G4 box; other site
596154011410	G5 box; other site
596154011411	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
596154011412	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
596154011413	Transposase; Region: HTH_Tnp_1; pfam01527
596154011414	HTH-like domain; Region: HTH_21; pfam13276
596154011415	Transposase; Region: HTH_Tnp_1; pfam01527
596154011416	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
596154011417	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
596154011418	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
596154011419	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
596154011420	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
596154011421	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
596154011422	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
596154011423	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
596154011424	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
596154011425	Integrase core domain; Region: rve; pfam00665
596154011426	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
596154011427	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
596154011428	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154011429	active site
596154011430	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
596154011431	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
596154011432	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
596154011433	catalytic residues [active]
596154011434	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154011435	putative substrate translocation pore; other site
596154011436	Major Facilitator Superfamily; Region: MFS_1; pfam07690
596154011437	Serine hydrolase; Region: Ser_hydrolase; pfam06821
596154011438	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
596154011439	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154011440	Major Facilitator Superfamily; Region: MFS_1; pfam07690
596154011441	putative substrate translocation pore; other site
596154011442	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
596154011443	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
596154011444	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
596154011445	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
596154011446	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
596154011447	NADP binding site [chemical binding]; other site
596154011448	dimer interface [polypeptide binding]; other site
596154011449	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
596154011450	Ligand Binding Site [chemical binding]; other site
596154011451	Hemerythrin-like domain; Region: Hr-like; cd12108
596154011452	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
596154011453	[2Fe-2S] cluster binding site [ion binding]; other site
596154011454	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
596154011455	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
596154011456	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
596154011457	DNA binding residues [nucleotide binding]
596154011458	dimerization interface [polypeptide binding]; other site
596154011459	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
596154011460	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
596154011461	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
596154011462	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
596154011463	Protein export membrane protein; Region: SecD_SecF; cl14618
596154011464	Predicted membrane protein [Function unknown]; Region: COG2855
596154011465	Predicted membrane protein [Function unknown]; Region: COG1238
596154011466	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
596154011467	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
596154011468	FMN binding site [chemical binding]; other site
596154011469	active site
596154011470	catalytic residues [active]
596154011471	substrate binding site [chemical binding]; other site
596154011472	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
596154011473	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
596154011474	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
596154011475	purine monophosphate binding site [chemical binding]; other site
596154011476	dimer interface [polypeptide binding]; other site
596154011477	putative catalytic residues [active]
596154011478	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
596154011479	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
596154011480	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
596154011481	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
596154011482	inhibitor-cofactor binding pocket; inhibition site
596154011483	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154011484	catalytic residue [active]
596154011485	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
596154011486	substrate binding site [chemical binding]; other site
596154011487	ATP binding site [chemical binding]; other site
596154011488	Rubredoxin [Energy production and conversion]; Region: COG1773
596154011489	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
596154011490	iron binding site [ion binding]; other site
596154011491	Response regulator receiver domain; Region: Response_reg; pfam00072
596154011492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154011493	active site
596154011494	phosphorylation site [posttranslational modification]
596154011495	intermolecular recognition site; other site
596154011496	dimerization interface [polypeptide binding]; other site
596154011497	Response regulator receiver domain; Region: Response_reg; pfam00072
596154011498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154011499	active site
596154011500	phosphorylation site [posttranslational modification]
596154011501	intermolecular recognition site; other site
596154011502	dimerization interface [polypeptide binding]; other site
596154011503	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
596154011504	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
596154011505	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
596154011506	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
596154011507	dimer interface [polypeptide binding]; other site
596154011508	putative CheW interface [polypeptide binding]; other site
596154011509	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
596154011510	putative binding surface; other site
596154011511	active site
596154011512	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
596154011513	putative binding surface; other site
596154011514	active site
596154011515	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
596154011516	putative binding surface; other site
596154011517	active site
596154011518	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
596154011519	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
596154011520	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154011521	ATP binding site [chemical binding]; other site
596154011522	Mg2+ binding site [ion binding]; other site
596154011523	G-X-G motif; other site
596154011524	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
596154011525	Response regulator receiver domain; Region: Response_reg; pfam00072
596154011526	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154011527	active site
596154011528	phosphorylation site [posttranslational modification]
596154011529	intermolecular recognition site; other site
596154011530	dimerization interface [polypeptide binding]; other site
596154011531	hypothetical protein; Validated; Region: PRK00228
596154011532	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
596154011533	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
596154011534	active site
596154011535	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
596154011536	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
596154011537	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
596154011538	dihydroorotase; Provisional; Region: PRK07627
596154011539	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
596154011540	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
596154011541	active site
596154011542	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
596154011543	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
596154011544	putative acyl-acceptor binding pocket; other site
596154011545	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
596154011546	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
596154011547	Walker A/P-loop; other site
596154011548	ATP binding site [chemical binding]; other site
596154011549	Q-loop/lid; other site
596154011550	ABC transporter signature motif; other site
596154011551	Walker B; other site
596154011552	D-loop; other site
596154011553	H-loop/switch region; other site
596154011554	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
596154011555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154011556	dimer interface [polypeptide binding]; other site
596154011557	conserved gate region; other site
596154011558	putative PBP binding loops; other site
596154011559	ABC-ATPase subunit interface; other site
596154011560	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
596154011561	ArsC family; Region: ArsC; pfam03960
596154011562	catalytic residues [active]
596154011563	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
596154011564	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
596154011565	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
596154011566	protein binding site [polypeptide binding]; other site
596154011567	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
596154011568	protein binding site [polypeptide binding]; other site
596154011569	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
596154011570	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154011571	active site
596154011572	phosphorylation site [posttranslational modification]
596154011573	intermolecular recognition site; other site
596154011574	dimerization interface [polypeptide binding]; other site
596154011575	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
596154011576	DNA binding site [nucleotide binding]
596154011577	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154011578	dimer interface [polypeptide binding]; other site
596154011579	phosphorylation site [posttranslational modification]
596154011580	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154011581	ATP binding site [chemical binding]; other site
596154011582	Mg2+ binding site [ion binding]; other site
596154011583	G-X-G motif; other site
596154011584	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
596154011585	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
596154011586	putative active site [active]
596154011587	catalytic site [active]
596154011588	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
596154011589	putative active site [active]
596154011590	catalytic site [active]
596154011591	heme bH binding site [chemical binding]; other site
596154011592	intrachain domain interface; other site
596154011593	heme bL binding site [chemical binding]; other site
596154011594	interchain domain interface [polypeptide binding]; other site
596154011595	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
596154011596	Qo binding site; other site
596154011597	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
596154011598	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
596154011599	catalytic loop [active]
596154011600	iron binding site [ion binding]; other site
596154011601	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
596154011602	FAD binding pocket [chemical binding]; other site
596154011603	FAD binding motif [chemical binding]; other site
596154011604	phosphate binding motif [ion binding]; other site
596154011605	beta-alpha-beta structure motif; other site
596154011606	NAD binding pocket [chemical binding]; other site
596154011607	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
596154011608	intrachain domain interface; other site
596154011609	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
596154011610	heme bH binding site [chemical binding]; other site
596154011611	Qo binding site; other site
596154011612	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
596154011613	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
596154011614	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
596154011615	Cu(I) binding site [ion binding]; other site
596154011616	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
596154011617	UbiA prenyltransferase family; Region: UbiA; pfam01040
596154011618	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
596154011619	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
596154011620	Low-spin heme binding site [chemical binding]; other site
596154011621	D-pathway; other site
596154011622	Putative water exit pathway; other site
596154011623	Binuclear center (active site) [active]
596154011624	K-pathway; other site
596154011625	Putative proton exit pathway; other site
596154011626	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
596154011627	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
596154011628	Family of unknown function (DUF490); Region: DUF490; pfam04357
596154011629	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
596154011630	Surface antigen; Region: Bac_surface_Ag; pfam01103
596154011631	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
596154011632	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
596154011633	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
596154011634	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154011635	substrate binding site [chemical binding]; other site
596154011636	oxyanion hole (OAH) forming residues; other site
596154011637	trimer interface [polypeptide binding]; other site
596154011638	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154011639	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154011640	active site
596154011641	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154011642	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154011643	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154011644	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
596154011645	DNA-binding site [nucleotide binding]; DNA binding site
596154011646	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
596154011647	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154011648	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
596154011649	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
596154011650	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154011651	Walker A motif; other site
596154011652	ATP binding site [chemical binding]; other site
596154011653	Walker B motif; other site
596154011654	arginine finger; other site
596154011655	Cytochrome c553 [Energy production and conversion]; Region: COG2863
596154011656	Cytochrome c; Region: Cytochrom_C; cl11414
596154011657	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
596154011658	Ligand Binding Site [chemical binding]; other site
596154011659	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
596154011660	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
596154011661	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
596154011662	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154011663	Coenzyme A transferase; Region: CoA_trans; cl17247
596154011664	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
596154011665	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
596154011666	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
596154011667	dimer interface [polypeptide binding]; other site
596154011668	active site
596154011669	short chain dehydrogenase; Provisional; Region: PRK07577
596154011670	classical (c) SDRs; Region: SDR_c; cd05233
596154011671	NAD(P) binding site [chemical binding]; other site
596154011672	active site
596154011673	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154011674	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154011675	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
596154011676	putative substrate binding pocket [chemical binding]; other site
596154011677	putative dimerization interface [polypeptide binding]; other site
596154011678	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154011679	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
596154011680	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
596154011681	metal binding site [ion binding]; metal-binding site
596154011682	putative dimer interface [polypeptide binding]; other site
596154011683	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154011684	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154011685	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
596154011686	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
596154011687	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154011688	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
596154011689	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
596154011690	hypothetical protein; Provisional; Region: PRK14812
596154011691	substrate binding site [chemical binding]; other site
596154011692	isopropylmalate isomerase large subunit; Provisional; Region: PRK12466
596154011693	substrate binding site [chemical binding]; other site
596154011694	ligand binding site [chemical binding]; other site
596154011695	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
596154011696	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
596154011697	tetramer interface [polypeptide binding]; other site
596154011698	active site
596154011699	Mg2+/Mn2+ binding site [ion binding]; other site
596154011700	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
596154011701	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154011702	DNA-binding site [nucleotide binding]; DNA binding site
596154011703	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
596154011704	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
596154011705	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
596154011706	TrkA-N domain; Region: TrkA_N; pfam02254
596154011707	LysE type translocator; Region: LysE; cl00565
596154011708	ParA-like protein; Provisional; Region: PHA02518
596154011709	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
596154011710	P-loop; other site
596154011711	Magnesium ion binding site [ion binding]; other site
596154011712	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154011713	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154011714	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
596154011715	putative effector binding pocket; other site
596154011716	dimerization interface [polypeptide binding]; other site
596154011717	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
596154011718	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
596154011719	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
596154011720	active site
596154011721	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
596154011722	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
596154011723	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
596154011724	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
596154011725	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
596154011726	Cytochrome c; Region: Cytochrom_C; pfam00034
596154011727	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
596154011728	Subunit I/III interface [polypeptide binding]; other site
596154011729	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
596154011730	D-pathway; other site
596154011731	Subunit I/VIIc interface [polypeptide binding]; other site
596154011732	Subunit I/IV interface [polypeptide binding]; other site
596154011733	Subunit I/II interface [polypeptide binding]; other site
596154011734	Low-spin heme (heme a) binding site [chemical binding]; other site
596154011735	Subunit I/VIIa interface [polypeptide binding]; other site
596154011736	Subunit I/VIa interface [polypeptide binding]; other site
596154011737	Dimer interface; other site
596154011738	Putative water exit pathway; other site
596154011739	Binuclear center (heme a3/CuB) [ion binding]; other site
596154011740	K-pathway; other site
596154011741	Subunit I/Vb interface [polypeptide binding]; other site
596154011742	Putative proton exit pathway; other site
596154011743	Subunit I/VIb interface; other site
596154011744	Subunit I/VIc interface [polypeptide binding]; other site
596154011745	Electron transfer pathway; other site
596154011746	Subunit I/VIIIb interface [polypeptide binding]; other site
596154011747	Subunit I/VIIb interface [polypeptide binding]; other site
596154011748	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
596154011749	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
596154011750	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
596154011751	Subunit III/VIIa interface [polypeptide binding]; other site
596154011752	Phospholipid binding site [chemical binding]; other site
596154011753	Subunit I/III interface [polypeptide binding]; other site
596154011754	Subunit III/VIb interface [polypeptide binding]; other site
596154011755	Subunit III/VIa interface; other site
596154011756	Subunit III/Vb interface [polypeptide binding]; other site
596154011757	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
596154011758	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
596154011759	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
596154011760	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
596154011761	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
596154011762	UbiA prenyltransferase family; Region: UbiA; pfam01040
596154011763	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
596154011764	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
596154011765	Cu(I) binding site [ion binding]; other site
596154011766	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154011767	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
596154011768	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
596154011769	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
596154011770	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
596154011771	DNA binding residues [nucleotide binding]
596154011772	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
596154011773	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
596154011774	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
596154011775	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
596154011776	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
596154011777	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
596154011778	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
596154011779	Transposase; Region: HTH_Tnp_1; pfam01527
596154011780	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
596154011781	HTH-like domain; Region: HTH_21; pfam13276
596154011782	Transposase; Region: HTH_Tnp_1; pfam01527
596154011783	Sporulation related domain; Region: SPOR; pfam05036
596154011784	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
596154011785	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
596154011786	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
596154011787	FeS/SAM binding site; other site
596154011788	HemN C-terminal domain; Region: HemN_C; pfam06969
596154011789	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
596154011790	active site
596154011791	dimerization interface [polypeptide binding]; other site
596154011792	ribonuclease PH; Reviewed; Region: rph; PRK00173
596154011793	Ribonuclease PH; Region: RNase_PH_bact; cd11362
596154011794	hexamer interface [polypeptide binding]; other site
596154011795	active site
596154011796	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
596154011797	Protein phosphatase 2C; Region: PP2C; pfam00481
596154011798	active site
596154011799	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
596154011800	Catalytic domain of Protein Kinases; Region: PKc; cd00180
596154011801	active site
596154011802	ATP binding site [chemical binding]; other site
596154011803	substrate binding site [chemical binding]; other site
596154011804	activation loop (A-loop); other site
596154011805	hypothetical protein; Provisional; Region: PRK11820
596154011806	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
596154011807	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
596154011808	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
596154011809	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
596154011810	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
596154011811	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
596154011812	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
596154011813	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
596154011814	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
596154011815	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
596154011816	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
596154011817	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
596154011818	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154011819	Walker A motif; other site
596154011820	ATP binding site [chemical binding]; other site
596154011821	Walker B motif; other site
596154011822	arginine finger; other site
596154011823	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
596154011824	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
596154011825	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
596154011826	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
596154011827	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
596154011828	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
596154011829	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
596154011830	catalytic site [active]
596154011831	G-X2-G-X-G-K; other site
596154011832	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
596154011833	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
596154011834	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
596154011835	Zn2+ binding site [ion binding]; other site
596154011836	Mg2+ binding site [ion binding]; other site
596154011837	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
596154011838	synthetase active site [active]
596154011839	NTP binding site [chemical binding]; other site
596154011840	metal binding site [ion binding]; metal-binding site
596154011841	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
596154011842	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
596154011843	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
596154011844	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
596154011845	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
596154011846	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
596154011847	16S/18S rRNA binding site [nucleotide binding]; other site
596154011848	S13e-L30e interaction site [polypeptide binding]; other site
596154011849	25S rRNA binding site [nucleotide binding]; other site
596154011850	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
596154011851	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
596154011852	RNase E interface [polypeptide binding]; other site
596154011853	trimer interface [polypeptide binding]; other site
596154011854	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
596154011855	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
596154011856	RNase E interface [polypeptide binding]; other site
596154011857	trimer interface [polypeptide binding]; other site
596154011858	active site
596154011859	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
596154011860	putative nucleic acid binding region [nucleotide binding]; other site
596154011861	G-X-X-G motif; other site
596154011862	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
596154011863	RNA binding site [nucleotide binding]; other site
596154011864	domain interface; other site
596154011865	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
596154011866	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
596154011867	NAD(P) binding site [chemical binding]; other site
596154011868	triosephosphate isomerase; Provisional; Region: PRK14567
596154011869	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
596154011870	substrate binding site [chemical binding]; other site
596154011871	dimer interface [polypeptide binding]; other site
596154011872	catalytic triad [active]
596154011873	Preprotein translocase SecG subunit; Region: SecG; pfam03840
596154011874	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
596154011875	NADH dehydrogenase subunit B; Validated; Region: PRK06411
596154011876	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
596154011877	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
596154011878	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
596154011879	NADH dehydrogenase subunit D; Validated; Region: PRK06075
596154011880	NADH dehydrogenase subunit E; Validated; Region: PRK07539
596154011881	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
596154011882	putative dimer interface [polypeptide binding]; other site
596154011883	[2Fe-2S] cluster binding site [ion binding]; other site
596154011884	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
596154011885	SLBB domain; Region: SLBB; pfam10531
596154011886	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
596154011887	NADH dehydrogenase subunit G; Validated; Region: PRK09129
596154011888	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
596154011889	catalytic loop [active]
596154011890	iron binding site [ion binding]; other site
596154011891	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
596154011892	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
596154011893	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
596154011894	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
596154011895	4Fe-4S binding domain; Region: Fer4; pfam00037
596154011896	4Fe-4S binding domain; Region: Fer4; pfam00037
596154011897	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
596154011898	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
596154011899	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
596154011900	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
596154011901	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
596154011902	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
596154011903	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
596154011904	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
596154011905	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
596154011906	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
596154011907	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
596154011908	Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
596154011909	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
596154011910	glutamate dehydrogenase; Provisional; Region: PRK09414
596154011911	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
596154011912	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
596154011913	NAD(P) binding site [chemical binding]; other site
596154011914	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
596154011915	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154011916	ATP binding site [chemical binding]; other site
596154011917	Mg2+ binding site [ion binding]; other site
596154011918	G-X-G motif; other site
596154011919	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
596154011920	ATP binding site [chemical binding]; other site
596154011921	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
596154011922	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
596154011923	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
596154011924	guanine deaminase; Provisional; Region: PRK09228
596154011925	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
596154011926	active site
596154011927	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
596154011928	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154011929	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154011930	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154011931	dimerization interface [polypeptide binding]; other site
596154011932	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
596154011933	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
596154011934	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
596154011935	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
596154011936	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
596154011937	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
596154011938	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
596154011939	AMIN domain; Region: AMIN; pfam11741
596154011940	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
596154011941	active site
596154011942	metal binding site [ion binding]; metal-binding site
596154011943	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
596154011944	epoxyqueuosine reductase; Region: TIGR00276
596154011945	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
596154011946	Predicted permeases [General function prediction only]; Region: COG0679
596154011947	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154011948	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
596154011949	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
596154011950	active site
596154011951	Int/Topo IB signature motif; other site
596154011952	Methyltransferase domain; Region: Methyltransf_11; pfam08241
596154011953	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
596154011954	ThiC-associated domain; Region: ThiC-associated; pfam13667
596154011955	ThiC family; Region: ThiC; pfam01964
596154011956	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
596154011957	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
596154011958	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154011959	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
596154011960	Putative cyclase; Region: Cyclase; cl00814
596154011961	acyl-CoA synthetase; Validated; Region: PRK06164
596154011962	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154011963	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154011964	acyl-activating enzyme (AAE) consensus motif; other site
596154011965	acyl-activating enzyme (AAE) consensus motif; other site
596154011966	AMP binding site [chemical binding]; other site
596154011967	active site
596154011968	CoA binding site [chemical binding]; other site
596154011969	short chain dehydrogenase; Provisional; Region: PRK07577
596154011970	classical (c) SDRs; Region: SDR_c; cd05233
596154011971	NAD(P) binding site [chemical binding]; other site
596154011972	active site
596154011973	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154011974	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
596154011975	putative ligand binding site [chemical binding]; other site
596154011976	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154011977	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154011978	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154011979	active site
596154011980	cell division protein FtsZ; Validated; Region: PRK09330
596154011981	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
596154011982	nucleotide binding site [chemical binding]; other site
596154011983	SulA interaction site; other site
596154011984	cell division protein FtsA; Region: ftsA; TIGR01174
596154011985	Cell division protein FtsA; Region: FtsA; smart00842
596154011986	Cell division protein FtsA; Region: FtsA; pfam14450
596154011987	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
596154011988	Cell division protein FtsQ; Region: FtsQ; pfam03799
596154011989	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
596154011990	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
596154011991	ATP-grasp domain; Region: ATP-grasp_4; cl17255
596154011992	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
596154011993	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
596154011994	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
596154011995	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
596154011996	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
596154011997	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
596154011998	active site
596154011999	homodimer interface [polypeptide binding]; other site
596154012000	cell division protein FtsW; Region: ftsW; TIGR02614
596154012001	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
596154012002	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
596154012003	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
596154012004	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
596154012005	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
596154012006	Mg++ binding site [ion binding]; other site
596154012007	putative catalytic motif [active]
596154012008	putative substrate binding site [chemical binding]; other site
596154012009	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
596154012010	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
596154012011	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
596154012012	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
596154012013	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
596154012014	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
596154012015	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
596154012016	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
596154012017	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
596154012018	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
596154012019	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
596154012020	Cell division protein FtsL; Region: FtsL; pfam04999
596154012021	MraW methylase family; Region: Methyltransf_5; cl17771
596154012022	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
596154012023	cell division protein MraZ; Reviewed; Region: PRK00326
596154012024	MraZ protein; Region: MraZ; pfam02381
596154012025	MraZ protein; Region: MraZ; pfam02381
596154012026	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
596154012027	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154012028	Walker A motif; other site
596154012029	ATP binding site [chemical binding]; other site
596154012030	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154012031	Walker B motif; other site
596154012032	arginine finger; other site
596154012033	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
596154012034	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
596154012035	active site
596154012036	HslU subunit interaction site [polypeptide binding]; other site
596154012037	STAS domain; Region: STAS_2; pfam13466
596154012038	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
596154012039	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
596154012040	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
596154012041	P-loop, Walker A motif; other site
596154012042	Base recognition motif; other site
596154012043	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
596154012044	Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534
596154012045	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
596154012046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154012047	active site
596154012048	phosphorylation site [posttranslational modification]
596154012049	intermolecular recognition site; other site
596154012050	dimerization interface [polypeptide binding]; other site
596154012051	Helix-turn-helix domain; Region: HTH_17; pfam12728
596154012052	Response regulator receiver domain; Region: Response_reg; pfam00072
596154012053	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154012054	active site
596154012055	phosphorylation site [posttranslational modification]
596154012056	intermolecular recognition site; other site
596154012057	dimerization interface [polypeptide binding]; other site
596154012058	Response regulator receiver domain; Region: Response_reg; pfam00072
596154012059	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154012060	active site
596154012061	phosphorylation site [posttranslational modification]
596154012062	intermolecular recognition site; other site
596154012063	dimerization interface [polypeptide binding]; other site
596154012064	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154012065	PAS domain; Region: PAS_9; pfam13426
596154012066	putative active site [active]
596154012067	heme pocket [chemical binding]; other site
596154012068	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
596154012069	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154012070	putative active site [active]
596154012071	heme pocket [chemical binding]; other site
596154012072	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154012073	dimer interface [polypeptide binding]; other site
596154012074	phosphorylation site [posttranslational modification]
596154012075	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154012076	ATP binding site [chemical binding]; other site
596154012077	Mg2+ binding site [ion binding]; other site
596154012078	G-X-G motif; other site
596154012079	Helix-turn-helix domain; Region: HTH_17; pfam12728
596154012080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154012081	active site
596154012082	phosphorylation site [posttranslational modification]
596154012083	intermolecular recognition site; other site
596154012084	Response regulator receiver domain; Region: Response_reg; pfam00072
596154012085	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154012086	active site
596154012087	phosphorylation site [posttranslational modification]
596154012088	intermolecular recognition site; other site
596154012089	dimerization interface [polypeptide binding]; other site
596154012090	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
596154012091	Zn2+ binding site [ion binding]; other site
596154012092	Mg2+ binding site [ion binding]; other site
596154012093	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
596154012094	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154012095	putative active site [active]
596154012096	heme pocket [chemical binding]; other site
596154012097	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154012098	dimer interface [polypeptide binding]; other site
596154012099	phosphorylation site [posttranslational modification]
596154012100	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154012101	ATP binding site [chemical binding]; other site
596154012102	Mg2+ binding site [ion binding]; other site
596154012103	G-X-G motif; other site
596154012104	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
596154012105	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154012106	dimer interface [polypeptide binding]; other site
596154012107	phosphorylation site [posttranslational modification]
596154012108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154012109	ATP binding site [chemical binding]; other site
596154012110	Mg2+ binding site [ion binding]; other site
596154012111	G-X-G motif; other site
596154012112	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
596154012113	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
596154012114	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
596154012115	dimerization interface [polypeptide binding]; other site
596154012116	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
596154012117	dimer interface [polypeptide binding]; other site
596154012118	putative CheW interface [polypeptide binding]; other site
596154012119	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
596154012120	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
596154012121	active site
596154012122	DNA binding site [nucleotide binding]
596154012123	Int/Topo IB signature motif; other site
596154012124	Protein of unknown function, DUF484; Region: DUF484; cl17449
596154012125	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
596154012126	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
596154012127	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
596154012128	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
596154012129	nudix motif; other site
596154012130	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
596154012131	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
596154012132	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
596154012133	RNA binding surface [nucleotide binding]; other site
596154012134	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
596154012135	active site
596154012136	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
596154012137	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
596154012138	dimer interface [polypeptide binding]; other site
596154012139	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154012140	catalytic residue [active]
596154012141	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
596154012142	HSP70 interaction site [polypeptide binding]; other site
596154012143	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
596154012144	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
596154012145	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154012146	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154012147	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
596154012148	putative dimerization interface [polypeptide binding]; other site
596154012149	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
596154012150	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154012151	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154012152	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154012153	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
596154012154	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
596154012155	active site
596154012156	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154012157	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
596154012158	MarR family; Region: MarR_2; pfam12802
596154012159	2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206
596154012160	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154012161	NAD(P) binding site [chemical binding]; other site
596154012162	active site
596154012163	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154012164	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
596154012165	substrate binding site [chemical binding]; other site
596154012166	oxyanion hole (OAH) forming residues; other site
596154012167	trimer interface [polypeptide binding]; other site
596154012168	cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207
596154012169	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154012170	active site
596154012171	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
596154012172	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
596154012173	acyl-activating enzyme (AAE) consensus motif; other site
596154012174	putative AMP binding site [chemical binding]; other site
596154012175	putative active site [active]
596154012176	putative CoA binding site [chemical binding]; other site
596154012177	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
596154012178	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
596154012179	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
596154012180	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
596154012181	Ligand binding site [chemical binding]; other site
596154012182	Electron transfer flavoprotein domain; Region: ETF; pfam01012
596154012183	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
596154012184	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
596154012185	FMN binding site [chemical binding]; other site
596154012186	substrate binding site [chemical binding]; other site
596154012187	putative catalytic residue [active]
596154012188	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154012189	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154012190	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154012191	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
596154012192	CoenzymeA binding site [chemical binding]; other site
596154012193	subunit interaction site [polypeptide binding]; other site
596154012194	PHB binding site; other site
596154012195	enoyl-CoA hydratase; Provisional; Region: PRK07511
596154012196	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154012197	substrate binding site [chemical binding]; other site
596154012198	oxyanion hole (OAH) forming residues; other site
596154012199	trimer interface [polypeptide binding]; other site
596154012200	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
596154012201	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
596154012202	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
596154012203	active site
596154012204	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
596154012205	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154012206	active site
596154012207	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
596154012208	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
596154012209	dimer interface [polypeptide binding]; other site
596154012210	active site
596154012211	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
596154012212	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154012213	substrate binding site [chemical binding]; other site
596154012214	oxyanion hole (OAH) forming residues; other site
596154012215	trimer interface [polypeptide binding]; other site
596154012216	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
596154012217	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
596154012218	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
596154012219	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154012220	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154012221	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
596154012222	putative effector binding pocket; other site
596154012223	dimerization interface [polypeptide binding]; other site
596154012224	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
596154012225	putative transposase OrfB; Reviewed; Region: PHA02517
596154012226	HTH-like domain; Region: HTH_21; pfam13276
596154012227	Integrase core domain; Region: rve; pfam00665
596154012228	Integrase core domain; Region: rve_3; cl15866
596154012229	Transposase; Region: HTH_Tnp_1; cl17663
596154012230	heat shock protein HtpX; Provisional; Region: PRK05457
596154012231	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
596154012232	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
596154012233	active site
596154012234	substrate binding pocket [chemical binding]; other site
596154012235	dimer interface [polypeptide binding]; other site
596154012236	Uncharacterized conserved protein [Function unknown]; Region: COG3189
596154012237	Uncharacterized conserved protein [Function unknown]; Region: COG2128
596154012238	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
596154012239	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
596154012240	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
596154012241	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
596154012242	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
596154012243	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
596154012244	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154012245	Walker A/P-loop; other site
596154012246	ATP binding site [chemical binding]; other site
596154012247	Q-loop/lid; other site
596154012248	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
596154012249	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
596154012250	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
596154012251	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
596154012252	putative ligand binding site [chemical binding]; other site
596154012253	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
596154012254	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
596154012255	trimer interface [polypeptide binding]; other site
596154012256	eyelet of channel; other site
596154012257	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154012258	putative substrate translocation pore; other site
596154012259	Protein of unknown function, DUF485; Region: DUF485; pfam04341
596154012260	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
596154012261	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
596154012262	Na binding site [ion binding]; other site
596154012263	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
596154012264	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
596154012265	active site
596154012266	catalytic site [active]
596154012267	substrate binding site [chemical binding]; other site
596154012268	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
596154012269	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
596154012270	ligand binding site [chemical binding]; other site
596154012271	flexible hinge region; other site
596154012272	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
596154012273	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
596154012274	metal binding triad; other site
596154012275	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
596154012276	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
596154012277	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
596154012278	putative deacylase active site [active]
596154012279	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
596154012280	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
596154012281	active site
596154012282	catalytic residues [active]
596154012283	metal binding site [ion binding]; metal-binding site
596154012284	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
596154012285	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
596154012286	putative ligand binding site [chemical binding]; other site
596154012287	NAD binding site [chemical binding]; other site
596154012288	dimerization interface [polypeptide binding]; other site
596154012289	catalytic site [active]
596154012290	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
596154012291	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
596154012292	ATP-grasp domain; Region: ATP-grasp_4; cl17255
596154012293	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
596154012294	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
596154012295	carboxyltransferase (CT) interaction site; other site
596154012296	biotinylation site [posttranslational modification]; other site
596154012297	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
596154012298	enoyl-CoA hydratase; Provisional; Region: PRK05995
596154012299	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154012300	substrate binding site [chemical binding]; other site
596154012301	oxyanion hole (OAH) forming residues; other site
596154012302	trimer interface [polypeptide binding]; other site
596154012303	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
596154012304	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
596154012305	AMP-binding domain protein; Validated; Region: PRK08315
596154012306	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154012307	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
596154012308	acyl-activating enzyme (AAE) consensus motif; other site
596154012309	putative AMP binding site [chemical binding]; other site
596154012310	putative active site [active]
596154012311	putative CoA binding site [chemical binding]; other site
596154012312	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
596154012313	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
596154012314	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
596154012315	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
596154012316	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
596154012317	putative C-terminal domain interface [polypeptide binding]; other site
596154012318	putative GSH binding site (G-site) [chemical binding]; other site
596154012319	putative dimer interface [polypeptide binding]; other site
596154012320	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
596154012321	N-terminal domain interface [polypeptide binding]; other site
596154012322	dimer interface [polypeptide binding]; other site
596154012323	substrate binding pocket (H-site) [chemical binding]; other site
596154012324	choline dehydrogenase; Validated; Region: PRK02106
596154012325	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
596154012326	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
596154012327	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
596154012328	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
596154012329	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
596154012330	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154012331	TM-ABC transporter signature motif; other site
596154012332	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
596154012333	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
596154012334	TM-ABC transporter signature motif; other site
596154012335	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
596154012336	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
596154012337	Walker A/P-loop; other site
596154012338	ATP binding site [chemical binding]; other site
596154012339	Q-loop/lid; other site
596154012340	ABC transporter signature motif; other site
596154012341	Walker B; other site
596154012342	D-loop; other site
596154012343	H-loop/switch region; other site
596154012344	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
596154012345	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
596154012346	Walker A/P-loop; other site
596154012347	ATP binding site [chemical binding]; other site
596154012348	Q-loop/lid; other site
596154012349	ABC transporter signature motif; other site
596154012350	Walker B; other site
596154012351	D-loop; other site
596154012352	H-loop/switch region; other site
596154012353	choline dehydrogenase; Validated; Region: PRK02106
596154012354	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
596154012355	crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155
596154012356	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
596154012357	acyl-activating enzyme (AAE) consensus motif; other site
596154012358	putative AMP binding site [chemical binding]; other site
596154012359	putative active site [active]
596154012360	putative CoA binding site [chemical binding]; other site
596154012361	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
596154012362	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154012363	DNA-binding site [nucleotide binding]; DNA binding site
596154012364	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
596154012365	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154012366	homodimer interface [polypeptide binding]; other site
596154012367	catalytic residue [active]
596154012368	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
596154012369	homodimer interface [polypeptide binding]; other site
596154012370	catalytic residues [active]
596154012371	NAD binding site [chemical binding]; other site
596154012372	substrate binding pocket [chemical binding]; other site
596154012373	flexible flap; other site
596154012374	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
596154012375	PAS fold; Region: PAS; pfam00989
596154012376	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
596154012377	putative active site [active]
596154012378	heme pocket [chemical binding]; other site
596154012379	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154012380	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154012381	metal binding site [ion binding]; metal-binding site
596154012382	active site
596154012383	I-site; other site
596154012384	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
596154012385	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
596154012386	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
596154012387	PAS domain; Region: PAS_9; pfam13426
596154012388	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154012389	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154012390	metal binding site [ion binding]; metal-binding site
596154012391	active site
596154012392	I-site; other site
596154012393	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
596154012394	hypothetical protein; Provisional; Region: PRK01842
596154012395	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
596154012396	Predicted membrane protein [Function unknown]; Region: COG2323
596154012397	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154012398	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
596154012399	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154012400	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
596154012401	active site pocket [active]
596154012402	oxyanion hole [active]
596154012403	catalytic triad [active]
596154012404	active site nucleophile [active]
596154012405	Protein of unknown function (DUF1177); Region: DUF1177; pfam06675
596154012406	AroM protein; Region: AroM; cl17601
596154012407	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154012408	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154012409	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154012410	active site
596154012411	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
596154012412	C factor cell-cell signaling protein; Provisional; Region: PRK09009
596154012413	NADP binding site [chemical binding]; other site
596154012414	homodimer interface [polypeptide binding]; other site
596154012415	active site
596154012416	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
596154012417	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
596154012418	dimer interface [polypeptide binding]; other site
596154012419	active site
596154012420	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
596154012421	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
596154012422	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
596154012423	active site clefts [active]
596154012424	zinc binding site [ion binding]; other site
596154012425	dimer interface [polypeptide binding]; other site
596154012426	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
596154012427	isovaleryl-CoA dehydrogenase; Region: PLN02519
596154012428	substrate binding site [chemical binding]; other site
596154012429	FAD binding site [chemical binding]; other site
596154012430	catalytic base [active]
596154012431	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
596154012432	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
596154012433	DNA binding residues [nucleotide binding]
596154012434	putative dimer interface [polypeptide binding]; other site
596154012435	ABC transporter ATPase component; Reviewed; Region: PRK11147
596154012436	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154012437	Walker A/P-loop; other site
596154012438	ATP binding site [chemical binding]; other site
596154012439	Q-loop/lid; other site
596154012440	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
596154012441	ABC transporter signature motif; other site
596154012442	Walker B; other site
596154012443	ABC transporter; Region: ABC_tran_2; pfam12848
596154012444	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
596154012445	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
596154012446	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154012447	active site
596154012448	phosphorylation site [posttranslational modification]
596154012449	intermolecular recognition site; other site
596154012450	dimerization interface [polypeptide binding]; other site
596154012451	CheB methylesterase; Region: CheB_methylest; pfam01339
596154012452	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487
596154012453	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
596154012454	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
596154012455	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154012456	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
596154012457	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
596154012458	putative binding surface; other site
596154012459	active site
596154012460	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
596154012461	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154012462	ATP binding site [chemical binding]; other site
596154012463	Mg2+ binding site [ion binding]; other site
596154012464	G-X-G motif; other site
596154012465	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
596154012466	Response regulator receiver domain; Region: Response_reg; pfam00072
596154012467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154012468	active site
596154012469	phosphorylation site [posttranslational modification]
596154012470	intermolecular recognition site; other site
596154012471	dimerization interface [polypeptide binding]; other site
596154012472	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154012473	Response regulator receiver domain; Region: Response_reg; pfam00072
596154012474	active site
596154012475	phosphorylation site [posttranslational modification]
596154012476	intermolecular recognition site; other site
596154012477	dimerization interface [polypeptide binding]; other site
596154012478	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
596154012479	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154012480	ATP binding site [chemical binding]; other site
596154012481	Mg2+ binding site [ion binding]; other site
596154012482	G-X-G motif; other site
596154012483	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
596154012484	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154012485	active site
596154012486	phosphorylation site [posttranslational modification]
596154012487	intermolecular recognition site; other site
596154012488	dimerization interface [polypeptide binding]; other site
596154012489	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
596154012490	DNA binding residues [nucleotide binding]
596154012491	dimerization interface [polypeptide binding]; other site
596154012492	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
596154012493	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
596154012494	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
596154012495	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
596154012496	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
596154012497	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
596154012498	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
596154012499	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
596154012500	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
596154012501	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
596154012502	Flagellar FliJ protein; Region: FliJ; cl09161
596154012503	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
596154012504	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
596154012505	Walker A motif/ATP binding site; other site
596154012506	Walker B motif; other site
596154012507	Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317
596154012508	Flagellar assembly protein FliH; Region: FliH; pfam02108
596154012509	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
596154012510	MgtE intracellular N domain; Region: MgtE_N; cl15244
596154012511	FliG C-terminal domain; Region: FliG_C; pfam01706
596154012512	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
596154012513	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
596154012514	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
596154012515	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
596154012516	Flagellar protein FliT; Region: FliT; pfam05400
596154012517	Flagellar protein FliS; Region: FliS; cl00654
596154012518	flagellar capping protein; Reviewed; Region: fliD; PRK08032
596154012519	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
596154012520	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
596154012521	flagellin; Reviewed; Region: PRK08869
596154012522	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
596154012523	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
596154012524	flagellin; Reviewed; Region: PRK08869
596154012525	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
596154012526	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
596154012527	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
596154012528	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
596154012529	putative ligand binding site [chemical binding]; other site
596154012530	putative catalytic site [active]
596154012531	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
596154012532	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
596154012533	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
596154012534	Probable Catalytic site; other site
596154012535	metal-binding site
596154012536	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
596154012537	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
596154012538	active site
596154012539	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
596154012540	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
596154012541	flagellar motor protein MotA; Validated; Region: PRK09110
596154012542	flagellar motor protein MotB; Validated; Region: motB; PRK09041
596154012543	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
596154012544	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
596154012545	ligand binding site [chemical binding]; other site
596154012546	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
596154012547	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154012548	active site
596154012549	phosphorylation site [posttranslational modification]
596154012550	intermolecular recognition site; other site
596154012551	dimerization interface [polypeptide binding]; other site
596154012552	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
596154012553	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
596154012554	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
596154012555	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
596154012556	FHIPEP family; Region: FHIPEP; pfam00771
596154012557	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995
596154012558	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
596154012559	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
596154012560	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
596154012561	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
596154012562	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
596154012563	DNA binding residues [nucleotide binding]
596154012564	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
596154012565	SAF-like; Region: SAF_2; pfam13144
596154012566	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
596154012567	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
596154012568	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
596154012569	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
596154012570	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
596154012571	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
596154012572	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
596154012573	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
596154012574	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
596154012575	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
596154012576	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
596154012577	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
596154012578	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
596154012579	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
596154012580	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
596154012581	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
596154012582	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
596154012583	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
596154012584	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
596154012585	Flagellar L-ring protein; Region: FlgH; pfam02107
596154012586	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
596154012587	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
596154012588	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
596154012589	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
596154012590	Rod binding protein; Region: Rod-binding; cl01626
596154012591	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
596154012592	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
596154012593	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
596154012594	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
596154012595	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
596154012596	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
596154012597	Nitronate monooxygenase; Region: NMO; pfam03060
596154012598	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
596154012599	FMN binding site [chemical binding]; other site
596154012600	substrate binding site [chemical binding]; other site
596154012601	putative catalytic residue [active]
596154012602	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
596154012603	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154012604	DNA-binding site [nucleotide binding]; DNA binding site
596154012605	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
596154012606	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154012607	homodimer interface [polypeptide binding]; other site
596154012608	catalytic residue [active]
596154012609	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
596154012610	EamA-like transporter family; Region: EamA; pfam00892
596154012611	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
596154012612	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
596154012613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154012614	homodimer interface [polypeptide binding]; other site
596154012615	catalytic residue [active]
596154012616	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
596154012617	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
596154012618	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
596154012619	tetramer interface [polypeptide binding]; other site
596154012620	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154012621	catalytic residue [active]
596154012622	Putative cyclase; Region: Cyclase; cl00814
596154012623	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154012624	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
596154012625	putative ligand binding site [chemical binding]; other site
596154012626	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
596154012627	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
596154012628	NAD(P) binding site [chemical binding]; other site
596154012629	active site
596154012630	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
596154012631	catalytic core [active]
596154012632	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154012633	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154012634	metal binding site [ion binding]; metal-binding site
596154012635	active site
596154012636	I-site; other site
596154012637	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
596154012638	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
596154012639	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
596154012640	N-terminal plug; other site
596154012641	ligand-binding site [chemical binding]; other site
596154012642	Creatinine amidohydrolase; Region: Creatininase; pfam02633
596154012643	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154012644	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
596154012645	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
596154012646	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
596154012647	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
596154012648	DsbD alpha interface [polypeptide binding]; other site
596154012649	catalytic residues [active]
596154012650	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
596154012651	putative catalytic residue [active]
596154012652	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
596154012653	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
596154012654	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
596154012655	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
596154012656	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
596154012657	substrate binding site [chemical binding]; other site
596154012658	active site
596154012659	primosome assembly protein PriA; Validated; Region: PRK05580
596154012660	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
596154012661	ATP binding site [chemical binding]; other site
596154012662	putative Mg++ binding site [ion binding]; other site
596154012663	helicase superfamily c-terminal domain; Region: HELICc; smart00490
596154012664	beta-ketothiolase; Provisional; Region: PRK09051
596154012665	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
596154012666	dimer interface [polypeptide binding]; other site
596154012667	active site
596154012668	enoyl-CoA hydratase; Provisional; Region: PRK06688
596154012669	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154012670	substrate binding site [chemical binding]; other site
596154012671	oxyanion hole (OAH) forming residues; other site
596154012672	trimer interface [polypeptide binding]; other site
596154012673	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
596154012674	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154012675	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154012676	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
596154012677	acyl-activating enzyme (AAE) consensus motif; other site
596154012678	acyl-activating enzyme (AAE) consensus motif; other site
596154012679	putative AMP binding site [chemical binding]; other site
596154012680	putative active site [active]
596154012681	putative CoA binding site [chemical binding]; other site
596154012682	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
596154012683	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
596154012684	Walker A/P-loop; other site
596154012685	ATP binding site [chemical binding]; other site
596154012686	Q-loop/lid; other site
596154012687	ABC transporter signature motif; other site
596154012688	Walker B; other site
596154012689	D-loop; other site
596154012690	H-loop/switch region; other site
596154012691	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154012692	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
596154012693	putative ligand binding site [chemical binding]; other site
596154012694	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
596154012695	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
596154012696	TM-ABC transporter signature motif; other site
596154012697	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
596154012698	TM-ABC transporter signature motif; other site
596154012699	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
596154012700	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
596154012701	Walker A/P-loop; other site
596154012702	ATP binding site [chemical binding]; other site
596154012703	Q-loop/lid; other site
596154012704	ABC transporter signature motif; other site
596154012705	Walker B; other site
596154012706	D-loop; other site
596154012707	H-loop/switch region; other site
596154012708	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154012709	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154012710	Predicted permeases [General function prediction only]; Region: COG0679
596154012711	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
596154012712	Part of AAA domain; Region: AAA_19; pfam13245
596154012713	Family description; Region: UvrD_C_2; pfam13538
596154012714	glycogen branching enzyme; Provisional; Region: PRK05402
596154012715	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
596154012716	substrate binding site [chemical binding]; other site
596154012717	dimerization interface [polypeptide binding]; other site
596154012718	active site
596154012719	calcium binding site [ion binding]; other site
596154012720	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
596154012721	Uncharacterized conserved protein [Function unknown]; Region: COG1262
596154012722	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
596154012723	Sulfatase; Region: Sulfatase; pfam00884
596154012724	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
596154012725	active site
596154012726	metal binding site [ion binding]; metal-binding site
596154012727	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
596154012728	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
596154012729	putative active site [active]
596154012730	putative metal binding site [ion binding]; other site
596154012731	hypothetical protein; Provisional; Region: PRK06126
596154012732	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
596154012733	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
596154012734	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
596154012735	trimer interface [polypeptide binding]; other site
596154012736	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
596154012737	eyelet of channel; other site
596154012738	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154012739	DNA-binding site [nucleotide binding]; DNA binding site
596154012740	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
596154012741	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
596154012742	Ligand Binding Site [chemical binding]; other site
596154012743	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
596154012744	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
596154012745	Putative zinc ribbon domain; Region: DUF164; pfam02591
596154012746	PAS domain S-box; Region: sensory_box; TIGR00229
596154012747	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154012748	putative active site [active]
596154012749	heme pocket [chemical binding]; other site
596154012750	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
596154012751	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154012752	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154012753	hypothetical protein; Validated; Region: PRK06201
596154012754	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
596154012755	Transcriptional regulators [Transcription]; Region: FadR; COG2186
596154012756	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154012757	DNA-binding site [nucleotide binding]; DNA binding site
596154012758	FCD domain; Region: FCD; pfam07729
596154012759	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
596154012760	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
596154012761	putative acyl-acceptor binding pocket; other site
596154012762	FtsH Extracellular; Region: FtsH_ext; pfam06480
596154012763	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
596154012764	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154012765	Walker A motif; other site
596154012766	ATP binding site [chemical binding]; other site
596154012767	Walker B motif; other site
596154012768	arginine finger; other site
596154012769	Peptidase family M41; Region: Peptidase_M41; pfam01434
596154012770	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
596154012771	active site
596154012772	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
596154012773	active site
596154012774	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
596154012775	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
596154012776	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
596154012777	putative NAD(P) binding site [chemical binding]; other site
596154012778	putative substrate binding site [chemical binding]; other site
596154012779	catalytic Zn binding site [ion binding]; other site
596154012780	structural Zn binding site [ion binding]; other site
596154012781	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154012782	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
596154012783	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
596154012784	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
596154012785	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
596154012786	FIST N domain; Region: FIST; smart00897
596154012787	FIST C domain; Region: FIST_C; pfam10442
596154012788	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
596154012789	IHF dimer interface [polypeptide binding]; other site
596154012790	IHF - DNA interface [nucleotide binding]; other site
596154012791	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
596154012792	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
596154012793	HipA N-terminal domain; Region: couple_hipA; TIGR03071
596154012794	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
596154012795	HipA-like N-terminal domain; Region: HipA_N; pfam07805
596154012796	HipA-like C-terminal domain; Region: HipA_C; pfam07804
596154012797	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154012798	non-specific DNA binding site [nucleotide binding]; other site
596154012799	salt bridge; other site
596154012800	sequence-specific DNA binding site [nucleotide binding]; other site
596154012801	Homeodomain-like domain; Region: HTH_23; pfam13384
596154012802	Winged helix-turn helix; Region: HTH_29; pfam13551
596154012803	DDE superfamily endonuclease; Region: DDE_3; pfam13358
596154012804	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
596154012805	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
596154012806	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
596154012807	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
596154012808	Winged helix-turn helix; Region: HTH_29; pfam13551
596154012809	Homeodomain-like domain; Region: HTH_32; pfam13565
596154012810	DDE superfamily endonuclease; Region: DDE_3; pfam13358
596154012811	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
596154012812	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154012813	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
596154012814	NAD(P) binding site [chemical binding]; other site
596154012815	active site
596154012816	putative transposase OrfB; Reviewed; Region: PHA02517
596154012817	HTH-like domain; Region: HTH_21; pfam13276
596154012818	Integrase core domain; Region: rve; pfam00665
596154012819	Integrase core domain; Region: rve_3; cl15866
596154012820	Transposase; Region: HTH_Tnp_1; cl17663
596154012821	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
596154012822	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
596154012823	non-specific DNA binding site [nucleotide binding]; other site
596154012824	salt bridge; other site
596154012825	sequence-specific DNA binding site [nucleotide binding]; other site
596154012826	Integrase core domain; Region: rve; pfam00665
596154012827	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
596154012828	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154012829	Walker A motif; other site
596154012830	ATP binding site [chemical binding]; other site
596154012831	Walker B motif; other site
596154012832	arginine finger; other site
596154012833	Cytochrome c; Region: Cytochrom_C; cl11414
596154012834	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
596154012835	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
596154012836	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
596154012837	putative hydrophobic ligand binding site [chemical binding]; other site
596154012838	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
596154012839	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
596154012840	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
596154012841	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
596154012842	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
596154012843	catalytic loop [active]
596154012844	iron binding site [ion binding]; other site
596154012845	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
596154012846	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
596154012847	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
596154012848	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
596154012849	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
596154012850	MoxR-like ATPases [General function prediction only]; Region: COG0714
596154012851	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
596154012852	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
596154012853	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
596154012854	putative hydrophobic ligand binding site [chemical binding]; other site
596154012855	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
596154012856	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
596154012857	XdhC Rossmann domain; Region: XdhC_C; pfam13478
596154012858	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
596154012859	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
596154012860	Ligand binding site; other site
596154012861	metal-binding site
596154012862	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154012863	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154012864	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154012865	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
596154012866	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
596154012867	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
596154012868	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154012869	active site
596154012870	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
596154012871	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154012872	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
596154012873	substrate binding site [chemical binding]; other site
596154012874	oxyanion hole (OAH) forming residues; other site
596154012875	trimer interface [polypeptide binding]; other site
596154012876	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
596154012877	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
596154012878	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
596154012879	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
596154012880	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
596154012881	dimer interface [polypeptide binding]; other site
596154012882	active site
596154012883	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
596154012884	classical (c) SDRs; Region: SDR_c; cd05233
596154012885	NAD(P) binding site [chemical binding]; other site
596154012886	active site
596154012887	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
596154012888	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154012889	acyl-activating enzyme (AAE) consensus motif; other site
596154012890	AMP binding site [chemical binding]; other site
596154012891	active site
596154012892	CoA binding site [chemical binding]; other site
596154012893	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
596154012894	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
596154012895	Walker A/P-loop; other site
596154012896	ATP binding site [chemical binding]; other site
596154012897	Q-loop/lid; other site
596154012898	ABC transporter signature motif; other site
596154012899	Walker B; other site
596154012900	D-loop; other site
596154012901	H-loop/switch region; other site
596154012902	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
596154012903	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
596154012904	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154012905	TM-ABC transporter signature motif; other site
596154012906	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154012907	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
596154012908	TM-ABC transporter signature motif; other site
596154012909	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
596154012910	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
596154012911	ligand binding site [chemical binding]; other site
596154012912	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
596154012913	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
596154012914	active site
596154012915	DNA binding site [nucleotide binding]
596154012916	Int/Topo IB signature motif; other site
596154012917	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
596154012918	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
596154012919	INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190
596154012920	Int/Topo IB signature motif; other site
596154012921	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
596154012922	Putative transposase; Region: Y2_Tnp; pfam04986
596154012923	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
596154012924	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
596154012925	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
596154012926	alphaNTD homodimer interface [polypeptide binding]; other site
596154012927	alphaNTD - beta interaction site [polypeptide binding]; other site
596154012928	alphaNTD - beta' interaction site [polypeptide binding]; other site
596154012929	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
596154012930	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
596154012931	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
596154012932	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
596154012933	RNA binding surface [nucleotide binding]; other site
596154012934	30S ribosomal protein S11; Validated; Region: PRK05309
596154012935	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
596154012936	30S ribosomal protein S13; Region: bact_S13; TIGR03631
596154012937	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
596154012938	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
596154012939	SecY translocase; Region: SecY; pfam00344
596154012940	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
596154012941	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
596154012942	23S rRNA binding site [nucleotide binding]; other site
596154012943	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
596154012944	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
596154012945	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
596154012946	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
596154012947	5S rRNA interface [nucleotide binding]; other site
596154012948	23S rRNA interface [nucleotide binding]; other site
596154012949	L5 interface [polypeptide binding]; other site
596154012950	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
596154012951	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
596154012952	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
596154012953	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
596154012954	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
596154012955	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
596154012956	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
596154012957	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
596154012958	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
596154012959	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
596154012960	RNA binding site [nucleotide binding]; other site
596154012961	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
596154012962	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
596154012963	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
596154012964	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
596154012965	putative DNA binding site [nucleotide binding]; other site
596154012966	putative Zn2+ binding site [ion binding]; other site
596154012967	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
596154012968	glycerol kinase; Provisional; Region: glpK; PRK00047
596154012969	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
596154012970	N- and C-terminal domain interface [polypeptide binding]; other site
596154012971	active site
596154012972	MgATP binding site [chemical binding]; other site
596154012973	catalytic site [active]
596154012974	metal binding site [ion binding]; metal-binding site
596154012975	glycerol binding site [chemical binding]; other site
596154012976	homotetramer interface [polypeptide binding]; other site
596154012977	homodimer interface [polypeptide binding]; other site
596154012978	FBP binding site [chemical binding]; other site
596154012979	protein IIAGlc interface [polypeptide binding]; other site
596154012980	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
596154012981	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
596154012982	CotH protein; Region: CotH; pfam08757
596154012983	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
596154012984	UbiA prenyltransferase family; Region: UbiA; pfam01040
596154012985	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
596154012986	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
596154012987	dimerization interface [polypeptide binding]; other site
596154012988	DPS ferroxidase diiron center [ion binding]; other site
596154012989	ion pore; other site
596154012990	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
596154012991	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154012992	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
596154012993	dimerization interface [polypeptide binding]; other site
596154012994	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
596154012995	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
596154012996	generic binding surface II; other site
596154012997	ssDNA binding site; other site
596154012998	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
596154012999	ATP binding site [chemical binding]; other site
596154013000	putative Mg++ binding site [ion binding]; other site
596154013001	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
596154013002	nucleotide binding region [chemical binding]; other site
596154013003	ATP-binding site [chemical binding]; other site
596154013004	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
596154013005	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
596154013006	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
596154013007	Zn2+ binding site [ion binding]; other site
596154013008	Mg2+ binding site [ion binding]; other site
596154013009	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
596154013010	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
596154013011	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
596154013012	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
596154013013	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
596154013014	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154013015	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154013016	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154013017	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154013018	dimerization interface [polypeptide binding]; other site
596154013019	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
596154013020	ligand binding site [chemical binding]; other site
596154013021	active site
596154013022	UGI interface [polypeptide binding]; other site
596154013023	catalytic site [active]
596154013024	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
596154013025	active site
596154013026	ribulose/triose binding site [chemical binding]; other site
596154013027	phosphate binding site [ion binding]; other site
596154013028	substrate (anthranilate) binding pocket [chemical binding]; other site
596154013029	product (indole) binding pocket [chemical binding]; other site
596154013030	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
596154013031	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
596154013032	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
596154013033	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
596154013034	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
596154013035	glutamine binding [chemical binding]; other site
596154013036	catalytic triad [active]
596154013037	putative transposase OrfB; Reviewed; Region: PHA02517
596154013038	HTH-like domain; Region: HTH_21; pfam13276
596154013039	Integrase core domain; Region: rve; pfam00665
596154013040	Integrase core domain; Region: rve_3; cl15866
596154013041	Transposase; Region: HTH_Tnp_1; cl17663
596154013042	RES domain; Region: RES; pfam08808
596154013043	Chorismate mutase type II; Region: CM_2; smart00830
596154013044	anthranilate synthase component I; Provisional; Region: PRK13565
596154013045	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
596154013046	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
596154013047	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
596154013048	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
596154013049	dimerization interface [polypeptide binding]; other site
596154013050	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
596154013051	dimer interface [polypeptide binding]; other site
596154013052	putative CheW interface [polypeptide binding]; other site
596154013053	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
596154013054	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
596154013055	dimerization interface [polypeptide binding]; other site
596154013056	PAS domain S-box; Region: sensory_box; TIGR00229
596154013057	PAS domain; Region: PAS; smart00091
596154013058	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154013059	PAS domain; Region: PAS_9; pfam13426
596154013060	putative active site [active]
596154013061	heme pocket [chemical binding]; other site
596154013062	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154013063	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154013064	metal binding site [ion binding]; metal-binding site
596154013065	active site
596154013066	I-site; other site
596154013067	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
596154013068	phosphoglycolate phosphatase; Provisional; Region: PRK13222
596154013069	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
596154013070	motif II; other site
596154013071	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
596154013072	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
596154013073	substrate binding site [chemical binding]; other site
596154013074	hexamer interface [polypeptide binding]; other site
596154013075	metal binding site [ion binding]; metal-binding site
596154013076	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
596154013077	Site-specific recombinase; Region: SpecificRecomb; pfam10136
596154013078	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
596154013079	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
596154013080	thiamine monophosphate kinase; Provisional; Region: PRK05731
596154013081	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
596154013082	ATP binding site [chemical binding]; other site
596154013083	dimerization interface [polypeptide binding]; other site
596154013084	bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355
596154013085	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
596154013086	Type II transport protein GspH; Region: GspH; pfam12019
596154013087	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
596154013088	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
596154013089	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
596154013090	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154013091	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154013092	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
596154013093	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
596154013094	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
596154013095	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
596154013096	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
596154013097	NAD binding site [chemical binding]; other site
596154013098	homotetramer interface [polypeptide binding]; other site
596154013099	homodimer interface [polypeptide binding]; other site
596154013100	substrate binding site [chemical binding]; other site
596154013101	active site
596154013102	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
596154013103	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
596154013104	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
596154013105	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154013106	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
596154013107	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
596154013108	Walker A/P-loop; other site
596154013109	ATP binding site [chemical binding]; other site
596154013110	Q-loop/lid; other site
596154013111	ABC transporter signature motif; other site
596154013112	Walker B; other site
596154013113	D-loop; other site
596154013114	H-loop/switch region; other site
596154013115	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
596154013116	Walker A/P-loop; other site
596154013117	ATP binding site [chemical binding]; other site
596154013118	Q-loop/lid; other site
596154013119	ABC transporter signature motif; other site
596154013120	Walker B; other site
596154013121	D-loop; other site
596154013122	H-loop/switch region; other site
596154013123	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
596154013124	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
596154013125	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
596154013126	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
596154013127	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
596154013128	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
596154013129	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
596154013130	dimer interaction site [polypeptide binding]; other site
596154013131	substrate-binding tunnel; other site
596154013132	active site
596154013133	catalytic site [active]
596154013134	substrate binding site [chemical binding]; other site
596154013135	phosphate acetyltransferase; Provisional; Region: PRK11890
596154013136	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
596154013137	propionate/acetate kinase; Provisional; Region: PRK12379
596154013138	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
596154013139	tetramer interfaces [polypeptide binding]; other site
596154013140	binuclear metal-binding site [ion binding]; other site
596154013141	Competence-damaged protein; Region: CinA; pfam02464
596154013142	Tar ligand binding domain homologue; Region: TarH; pfam02203
596154013143	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
596154013144	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
596154013145	dimer interface [polypeptide binding]; other site
596154013146	putative CheW interface [polypeptide binding]; other site
596154013147	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
596154013148	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
596154013149	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
596154013150	dimerization interface [polypeptide binding]; other site
596154013151	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154013152	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154013153	metal binding site [ion binding]; metal-binding site
596154013154	active site
596154013155	I-site; other site
596154013156	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
596154013157	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
596154013158	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154013159	active site
596154013160	phosphorylation site [posttranslational modification]
596154013161	intermolecular recognition site; other site
596154013162	dimerization interface [polypeptide binding]; other site
596154013163	ANTAR domain; Region: ANTAR; pfam03861
596154013164	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154013165	PAS domain; Region: PAS_9; pfam13426
596154013166	putative active site [active]
596154013167	heme pocket [chemical binding]; other site
596154013168	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
596154013169	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
596154013170	Mg2+ binding site [ion binding]; other site
596154013171	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
596154013172	SEC-C motif; Region: SEC-C; pfam02810
596154013173	PIN domain; Region: PIN_3; pfam13470
596154013174	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
596154013175	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
596154013176	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
596154013177	Cache domain; Region: Cache_1; pfam02743
596154013178	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
596154013179	dimerization interface [polypeptide binding]; other site
596154013180	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
596154013181	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
596154013182	dimer interface [polypeptide binding]; other site
596154013183	putative CheW interface [polypeptide binding]; other site
596154013184	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
596154013185	active site
596154013186	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
596154013187	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
596154013188	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
596154013189	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
596154013190	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
596154013191	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
596154013192	Walker A/P-loop; other site
596154013193	ATP binding site [chemical binding]; other site
596154013194	Q-loop/lid; other site
596154013195	ABC transporter signature motif; other site
596154013196	Walker B; other site
596154013197	D-loop; other site
596154013198	H-loop/switch region; other site
596154013199	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
596154013200	OstA-like protein; Region: OstA; pfam03968
596154013201	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
596154013202	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
596154013203	catalytic residues [active]
596154013204	hinge region; other site
596154013205	alpha helical domain; other site
596154013206	Sporulation related domain; Region: SPOR; pfam05036
596154013207	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
596154013208	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
596154013209	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
596154013210	active site
596154013211	HIGH motif; other site
596154013212	nucleotide binding site [chemical binding]; other site
596154013213	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
596154013214	KMSK motif region; other site
596154013215	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
596154013216	tRNA binding surface [nucleotide binding]; other site
596154013217	anticodon binding site; other site
596154013218	psiF repeat; Region: PsiF_repeat; pfam07769
596154013219	psiF repeat; Region: PsiF_repeat; pfam07769
596154013220	Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980
596154013221	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
596154013222	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
596154013223	PAS domain; Region: PAS; smart00091
596154013224	PAS fold; Region: PAS_7; pfam12860
596154013225	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
596154013226	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154013227	dimer interface [polypeptide binding]; other site
596154013228	phosphorylation site [posttranslational modification]
596154013229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154013230	ATP binding site [chemical binding]; other site
596154013231	Mg2+ binding site [ion binding]; other site
596154013232	G-X-G motif; other site
596154013233	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
596154013234	active site
596154013235	dimerization interface [polypeptide binding]; other site
596154013236	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
596154013237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154013238	active site
596154013239	phosphorylation site [posttranslational modification]
596154013240	intermolecular recognition site; other site
596154013241	dimerization interface [polypeptide binding]; other site
596154013242	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
596154013243	DNA binding residues [nucleotide binding]
596154013244	dimerization interface [polypeptide binding]; other site
596154013245	LysR family transcriptional regulator; Provisional; Region: PRK14997
596154013246	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154013247	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
596154013248	putative effector binding pocket; other site
596154013249	dimerization interface [polypeptide binding]; other site
596154013250	malate synthase G; Provisional; Region: PRK02999
596154013251	active site
596154013252	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
596154013253	4-oxalocrotonate tautomerase; Provisional; Region: PRK00745
596154013254	active site 1 [active]
596154013255	dimer interface [polypeptide binding]; other site
596154013256	hexamer interface [polypeptide binding]; other site
596154013257	active site 2 [active]
596154013258	Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596
596154013259	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
596154013260	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
596154013261	putative active site [active]
596154013262	putative dimer interface [polypeptide binding]; other site
596154013263	glutathione synthetase; Provisional; Region: PRK05246
596154013264	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
596154013265	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
596154013266	benzoate transporter; Region: benE; TIGR00843
596154013267	Benzoate membrane transport protein; Region: BenE; pfam03594
596154013268	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
596154013269	potassium uptake protein; Region: kup; TIGR00794
596154013270	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
596154013271	Glutamate-cysteine ligase; Region: GshA; pfam08886
596154013272	Cation transport protein; Region: TrkH; cl17365
596154013273	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
596154013274	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
596154013275	TrkA-N domain; Region: TrkA_N; pfam02254
596154013276	TrkA-N domain; Region: TrkA_N; pfam02254
596154013277	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
596154013278	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
596154013279	putative catalytic cysteine [active]
596154013280	ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187
596154013281	Astacin (Peptidase family M12A); Region: Astacin; pfam01400
596154013282	Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280
596154013283	active site
596154013284	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
596154013285	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
596154013286	Lipopolysaccharide-assembly; Region: LptE; cl01125
596154013287	leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396
596154013288	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
596154013289	HIGH motif; other site
596154013290	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
596154013291	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
596154013292	active site
596154013293	KMSKS motif; other site
596154013294	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
596154013295	tRNA binding surface [nucleotide binding]; other site
596154013296	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
596154013297	Mechanosensitive ion channel; Region: MS_channel; pfam00924
596154013298	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
596154013299	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
596154013300	NAD(P) binding site [chemical binding]; other site
596154013301	catalytic residues [active]
596154013302	DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388
596154013303	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154013304	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154013305	Walker A motif; other site
596154013306	ATP binding site [chemical binding]; other site
596154013307	Walker B motif; other site
596154013308	arginine finger; other site
596154013309	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
596154013310	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
596154013311	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
596154013312	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154013313	putative active site [active]
596154013314	heme pocket [chemical binding]; other site
596154013315	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154013316	putative active site [active]
596154013317	heme pocket [chemical binding]; other site
596154013318	GAF domain; Region: GAF; pfam01590
596154013319	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154013320	metal binding site [ion binding]; metal-binding site
596154013321	active site
596154013322	I-site; other site
596154013323	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
596154013324	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
596154013325	TolR protein; Region: tolR; TIGR02801
596154013326	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
596154013327	dihydrodipicolinate reductase; Provisional; Region: PRK00048
596154013328	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
596154013329	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
596154013330	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
596154013331	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
596154013332	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
596154013333	metal binding site 2 [ion binding]; metal-binding site
596154013334	putative DNA binding helix; other site
596154013335	metal binding site 1 [ion binding]; metal-binding site
596154013336	dimer interface [polypeptide binding]; other site
596154013337	structural Zn2+ binding site [ion binding]; other site
596154013338	HPr kinase/phosphorylase; Provisional; Region: PRK05428
596154013339	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
596154013340	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
596154013341	Hpr binding site; other site
596154013342	active site
596154013343	homohexamer subunit interaction site [polypeptide binding]; other site
596154013344	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
596154013345	active site
596154013346	phosphorylation site [posttranslational modification]
596154013347	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
596154013348	30S subunit binding site; other site
596154013349	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
596154013350	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
596154013351	active site
596154013352	ATP binding site [chemical binding]; other site
596154013353	substrate binding site [chemical binding]; other site
596154013354	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
596154013355	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
596154013356	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
596154013357	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
596154013358	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
596154013359	NAD binding site [chemical binding]; other site
596154013360	ATP-grasp domain; Region: ATP-grasp; pfam02222
596154013361	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
596154013362	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
596154013363	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
596154013364	active site
596154013365	catalytic triad [active]
596154013366	oxyanion hole [active]
596154013367	OmpW family; Region: OmpW; cl17427
596154013368	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
596154013369	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
596154013370	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
596154013371	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
596154013372	Glycoprotease family; Region: Peptidase_M22; pfam00814
596154013373	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
596154013374	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
596154013375	Coenzyme A binding pocket [chemical binding]; other site
596154013376	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
596154013377	active site
596154013378	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
596154013379	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
596154013380	Cl binding site [ion binding]; other site
596154013381	oligomer interface [polypeptide binding]; other site
596154013382	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
596154013383	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
596154013384	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
596154013385	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
596154013386	acyl-activating enzyme (AAE) consensus motif; other site
596154013387	putative AMP binding site [chemical binding]; other site
596154013388	putative active site [active]
596154013389	putative CoA binding site [chemical binding]; other site
596154013390	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
596154013391	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
596154013392	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
596154013393	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
596154013394	ligand binding site [chemical binding]; other site
596154013395	homodimer interface [polypeptide binding]; other site
596154013396	NAD(P) binding site [chemical binding]; other site
596154013397	trimer interface B [polypeptide binding]; other site
596154013398	trimer interface A [polypeptide binding]; other site
596154013399	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
596154013400	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
596154013401	intersubunit interface [polypeptide binding]; other site
596154013402	active site
596154013403	zinc binding site [ion binding]; other site
596154013404	Na+ binding site [ion binding]; other site
596154013405	pyruvate kinase; Provisional; Region: PRK05826
596154013406	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
596154013407	domain interfaces; other site
596154013408	active site
596154013409	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
596154013410	proline aminopeptidase P II; Provisional; Region: PRK10879
596154013411	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
596154013412	active site
596154013413	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
596154013414	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
596154013415	substrate binding site [chemical binding]; other site
596154013416	oxyanion hole (OAH) forming residues; other site
596154013417	trimer interface [polypeptide binding]; other site
596154013418	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
596154013419	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154013420	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154013421	thiolase; Provisional; Region: PRK06158
596154013422	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
596154013423	active site
596154013424	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
596154013425	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
596154013426	DUF35 OB-fold domain; Region: DUF35; pfam01796
596154013427	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154013428	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154013429	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154013430	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
596154013431	putative dimerization interface [polypeptide binding]; other site
596154013432	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
596154013433	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
596154013434	Substrate binding site; other site
596154013435	metal-binding site
596154013436	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
596154013437	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
596154013438	TPP-binding site [chemical binding]; other site
596154013439	dimer interface [polypeptide binding]; other site
596154013440	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
596154013441	PYR/PP interface [polypeptide binding]; other site
596154013442	dimer interface [polypeptide binding]; other site
596154013443	TPP binding site [chemical binding]; other site
596154013444	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
596154013445	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
596154013446	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
596154013447	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
596154013448	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
596154013449	Peptidase C26; Region: Peptidase_C26; pfam07722
596154013450	catalytic triad [active]
596154013451	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
596154013452	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154013453	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
596154013454	putative dimerization interface [polypeptide binding]; other site
596154013455	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
596154013456	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
596154013457	active site
596154013458	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
596154013459	classical (c) SDRs; Region: SDR_c; cd05233
596154013460	NAD(P) binding site [chemical binding]; other site
596154013461	active site
596154013462	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154013463	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
596154013464	Uncharacterized conserved protein [Function unknown]; Region: COG2128
596154013465	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
596154013466	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
596154013467	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
596154013468	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
596154013469	N-terminal plug; other site
596154013470	ligand-binding site [chemical binding]; other site
596154013471	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
596154013472	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154013473	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
596154013474	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154013475	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154013476	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
596154013477	putative effector binding pocket; other site
596154013478	dimerization interface [polypeptide binding]; other site
596154013479	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
596154013480	short chain dehydrogenase; Provisional; Region: PRK06181
596154013481	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154013482	NAD(P) binding site [chemical binding]; other site
596154013483	active site
596154013484	Uncharacterized conserved protein [Function unknown]; Region: COG3148
596154013485	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154013486	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154013487	thiolase; Provisional; Region: PRK06158
596154013488	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
596154013489	active site
596154013490	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
596154013491	DUF35 OB-fold domain; Region: DUF35; pfam01796
596154013492	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154013493	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
596154013494	CoA binding domain; Region: CoA_binding_2; pfam13380
596154013495	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
596154013496	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
596154013497	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
596154013498	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
596154013499	C-terminal domain interface [polypeptide binding]; other site
596154013500	GSH binding site (G-site) [chemical binding]; other site
596154013501	dimer interface [polypeptide binding]; other site
596154013502	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
596154013503	dimer interface [polypeptide binding]; other site
596154013504	N-terminal domain interface [polypeptide binding]; other site
596154013505	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642
596154013506	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154013507	NAD(P) binding site [chemical binding]; other site
596154013508	active site
596154013509	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
596154013510	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
596154013511	DNA topoisomerase III; Provisional; Region: PRK14724
596154013512	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
596154013513	active site
596154013514	putative interdomain interaction site [polypeptide binding]; other site
596154013515	putative metal-binding site [ion binding]; other site
596154013516	putative nucleotide binding site [chemical binding]; other site
596154013517	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
596154013518	domain I; other site
596154013519	DNA binding groove [nucleotide binding]
596154013520	phosphate binding site [ion binding]; other site
596154013521	domain II; other site
596154013522	domain III; other site
596154013523	nucleotide binding site [chemical binding]; other site
596154013524	catalytic site [active]
596154013525	domain IV; other site
596154013526	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
596154013527	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
596154013528	SWI complex, BAF60b domains; Region: SWIB; smart00151
596154013529	Proteins containing SET domain [General function prediction only]; Region: COG2940
596154013530	SET domain; Region: SET; pfam00856
596154013531	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
596154013532	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
596154013533	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
596154013534	Sporulation related domain; Region: SPOR; cl10051
596154013535	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
596154013536	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
596154013537	putative NAD(P) binding site [chemical binding]; other site
596154013538	structural Zn binding site [ion binding]; other site
596154013539	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
596154013540	active site 2 [active]
596154013541	active site 1 [active]
596154013542	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
596154013543	active site
596154013544	catalytic site [active]
596154013545	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154013546	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
596154013547	putative ligand binding site [chemical binding]; other site
596154013548	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
596154013549	acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188
596154013550	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154013551	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154013552	acyl-activating enzyme (AAE) consensus motif; other site
596154013553	AMP binding site [chemical binding]; other site
596154013554	active site
596154013555	CoA binding site [chemical binding]; other site
596154013556	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
596154013557	MarR family; Region: MarR_2; pfam12802
596154013558	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
596154013559	RES domain; Region: RES; smart00953
596154013560	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
596154013561	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
596154013562	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154013563	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
596154013564	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
596154013565	dimer interface [polypeptide binding]; other site
596154013566	phosphorylation site [posttranslational modification]
596154013567	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154013568	ATP binding site [chemical binding]; other site
596154013569	Mg2+ binding site [ion binding]; other site
596154013570	G-X-G motif; other site
596154013571	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
596154013572	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154013573	active site
596154013574	phosphorylation site [posttranslational modification]
596154013575	intermolecular recognition site; other site
596154013576	dimerization interface [polypeptide binding]; other site
596154013577	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
596154013578	DNA binding site [nucleotide binding]
596154013579	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
596154013580	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
596154013581	catalytic residue [active]
596154013582	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
596154013583	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154013584	putative PBP binding loops; other site
596154013585	dimer interface [polypeptide binding]; other site
596154013586	ABC-ATPase subunit interface; other site
596154013587	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154013588	dimer interface [polypeptide binding]; other site
596154013589	conserved gate region; other site
596154013590	putative PBP binding loops; other site
596154013591	ABC-ATPase subunit interface; other site
596154013592	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
596154013593	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154013594	Walker A/P-loop; other site
596154013595	ATP binding site [chemical binding]; other site
596154013596	Q-loop/lid; other site
596154013597	ABC transporter signature motif; other site
596154013598	Walker B; other site
596154013599	D-loop; other site
596154013600	H-loop/switch region; other site
596154013601	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
596154013602	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
596154013603	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
596154013604	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154013605	DNA-binding site [nucleotide binding]; DNA binding site
596154013606	FCD domain; Region: FCD; pfam07729
596154013607	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
596154013608	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
596154013609	putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250
596154013610	Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146
596154013611	NAD(P) binding site [chemical binding]; other site
596154013612	catalytic residues [active]
596154013613	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
596154013614	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
596154013615	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
596154013616	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
596154013617	alanine racemase; Reviewed; Region: alr; PRK00053
596154013618	active site
596154013619	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
596154013620	substrate binding site [chemical binding]; other site
596154013621	catalytic residues [active]
596154013622	dimer interface [polypeptide binding]; other site
596154013623	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
596154013624	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
596154013625	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
596154013626	putative DNA binding site [nucleotide binding]; other site
596154013627	AsnC family; Region: AsnC_trans_reg; pfam01037
596154013628	Transcriptional regulators [Transcription]; Region: MarR; COG1846
596154013629	MarR family; Region: MarR_2; pfam12802
596154013630	recombinase A; Provisional; Region: recA; PRK09354
596154013631	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
596154013632	hexamer interface [polypeptide binding]; other site
596154013633	Walker A motif; other site
596154013634	ATP binding site [chemical binding]; other site
596154013635	Walker B motif; other site
596154013636	RecX family; Region: RecX; cl00936
596154013637	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
596154013638	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
596154013639	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
596154013640	Protein export membrane protein; Region: SecD_SecF; pfam02355
596154013641	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
596154013642	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
596154013643	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
596154013644	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
596154013645	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
596154013646	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
596154013647	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
596154013648	dimer interface [polypeptide binding]; other site
596154013649	PYR/PP interface [polypeptide binding]; other site
596154013650	TPP binding site [chemical binding]; other site
596154013651	substrate binding site [chemical binding]; other site
596154013652	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
596154013653	TPP-binding site; other site
596154013654	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
596154013655	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
596154013656	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
596154013657	putative DNA binding site [nucleotide binding]; other site
596154013658	putative Zn2+ binding site [ion binding]; other site
596154013659	AsnC family; Region: AsnC_trans_reg; pfam01037
596154013660	Transmembrane secretion effector; Region: MFS_3; pfam05977
596154013661	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154013662	putative substrate translocation pore; other site
596154013663	MltA specific insert domain; Region: MltA; smart00925
596154013664	3D domain; Region: 3D; pfam06725
596154013665	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
596154013666	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
596154013667	ligand binding site [chemical binding]; other site
596154013668	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
596154013669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154013670	active site
596154013671	phosphorylation site [posttranslational modification]
596154013672	intermolecular recognition site; other site
596154013673	dimerization interface [polypeptide binding]; other site
596154013674	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
596154013675	DNA binding residues [nucleotide binding]
596154013676	dimerization interface [polypeptide binding]; other site
596154013677	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
596154013678	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
596154013679	putative active site [active]
596154013680	heme pocket [chemical binding]; other site
596154013681	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154013682	ATP binding site [chemical binding]; other site
596154013683	Mg2+ binding site [ion binding]; other site
596154013684	G-X-G motif; other site
596154013685	nitrilase; Region: PLN02798
596154013686	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
596154013687	putative active site [active]
596154013688	catalytic triad [active]
596154013689	dimer interface [polypeptide binding]; other site
596154013690	Protein of unknown function; Region: DUF3971; pfam13116
596154013691	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
596154013692	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
596154013693	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
596154013694	metal binding triad; other site
596154013695	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
596154013696	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
596154013697	metal binding triad; other site
596154013698	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154013699	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
596154013700	Protein export membrane protein; Region: SecD_SecF; cl14618
596154013701	putative glutathione S-transferase; Provisional; Region: PRK10357
596154013702	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
596154013703	putative C-terminal domain interface [polypeptide binding]; other site
596154013704	putative GSH binding site (G-site) [chemical binding]; other site
596154013705	putative dimer interface [polypeptide binding]; other site
596154013706	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
596154013707	dimer interface [polypeptide binding]; other site
596154013708	N-terminal domain interface [polypeptide binding]; other site
596154013709	putative substrate binding pocket (H-site) [chemical binding]; other site
596154013710	adenylosuccinate lyase; Provisional; Region: PRK09285
596154013711	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
596154013712	tetramer interface [polypeptide binding]; other site
596154013713	active site
596154013714	YaeQ protein; Region: YaeQ; pfam07152
596154013715	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
596154013716	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
596154013717	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
596154013718	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
596154013719	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154013720	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
596154013721	dimerization interface [polypeptide binding]; other site
596154013722	substrate binding pocket [chemical binding]; other site
596154013723	Predicted membrane protein [Function unknown]; Region: COG1950
596154013724	Peptidase family M48; Region: Peptidase_M48; cl12018
596154013725	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
596154013726	trimer interface [polypeptide binding]; other site
596154013727	dimer interface [polypeptide binding]; other site
596154013728	putative active site [active]
596154013729	Sulfatase; Region: Sulfatase; cl17466
596154013730	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
596154013731	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
596154013732	cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776
596154013733	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
596154013734	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
596154013735	phosphopeptide binding site; other site
596154013736	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
596154013737	active site
596154013738	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
596154013739	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
596154013740	CoA binding domain; Region: CoA_binding; smart00881
596154013741	CoA-ligase; Region: Ligase_CoA; pfam00549
596154013742	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
596154013743	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
596154013744	CoA-ligase; Region: Ligase_CoA; pfam00549
596154013745	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
596154013746	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
596154013747	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
596154013748	DNA protecting protein DprA; Region: dprA; TIGR00732
596154013749	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
596154013750	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
596154013751	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
596154013752	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
596154013753	active site
596154013754	catalytic residues [active]
596154013755	metal binding site [ion binding]; metal-binding site
596154013756	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
596154013757	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
596154013758	putative active site [active]
596154013759	substrate binding site [chemical binding]; other site
596154013760	putative cosubstrate binding site; other site
596154013761	catalytic site [active]
596154013762	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
596154013763	substrate binding site [chemical binding]; other site
596154013764	AzlC protein; Region: AzlC; pfam03591
596154013765	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
596154013766	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
596154013767	Phosphoglycerate kinase; Region: PGK; pfam00162
596154013768	substrate binding site [chemical binding]; other site
596154013769	hinge regions; other site
596154013770	ADP binding site [chemical binding]; other site
596154013771	catalytic site [active]
596154013772	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
596154013773	EamA-like transporter family; Region: EamA; pfam00892
596154013774	EamA-like transporter family; Region: EamA; pfam00892
596154013775	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
596154013776	active site
596154013777	dimer interface [polypeptide binding]; other site
596154013778	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154013779	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154013780	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
596154013781	dimerization interface [polypeptide binding]; other site
596154013782	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154013783	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
596154013784	active site
596154013785	Zn binding site [ion binding]; other site
596154013786	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
596154013787	dimerization interface [polypeptide binding]; other site
596154013788	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
596154013789	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
596154013790	dimer interface [polypeptide binding]; other site
596154013791	putative CheW interface [polypeptide binding]; other site
596154013792	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
596154013793	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
596154013794	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
596154013795	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
596154013796	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
596154013797	putative substrate translocation pore; other site
596154013798	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
596154013799	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
596154013800	dimer interface [polypeptide binding]; other site
596154013801	ssDNA binding site [nucleotide binding]; other site
596154013802	tetramer (dimer of dimers) interface [polypeptide binding]; other site
596154013803	L-lactate permease; Region: Lactate_perm; cl00701
596154013804	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
596154013805	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
596154013806	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
596154013807	Ligand Binding Site [chemical binding]; other site
596154013808	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154013809	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154013810	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
596154013811	putative dimerization interface [polypeptide binding]; other site
596154013812	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
596154013813	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154013814	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
596154013815	trimer interface [polypeptide binding]; other site
596154013816	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
596154013817	eyelet of channel; other site
596154013818	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
596154013819	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154013820	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
596154013821	putative dimerization interface [polypeptide binding]; other site
596154013822	tricarballylate dehydrogenase; Validated; Region: PRK08274
596154013823	tricarballylate utilization protein B; Provisional; Region: PRK15033
596154013824	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154013825	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
596154013826	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
596154013827	Walker A motif; other site
596154013828	ATP binding site [chemical binding]; other site
596154013829	Walker B motif; other site
596154013830	arginine finger; other site
596154013831	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
596154013832	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
596154013833	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
596154013834	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154013835	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
596154013836	CoA binding domain; Region: CoA_binding_2; pfam13380
596154013837	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
596154013838	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
596154013839	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111
596154013840	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
596154013841	ATP-grasp domain; Region: ATP-grasp_4; cl17255
596154013842	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
596154013843	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
596154013844	carboxyltransferase (CT) interaction site; other site
596154013845	biotinylation site [posttranslational modification]; other site
596154013846	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
596154013847	CoenzymeA binding site [chemical binding]; other site
596154013848	subunit interaction site [polypeptide binding]; other site
596154013849	PHB binding site; other site
596154013850	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
596154013851	nudix motif; other site
596154013852	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
596154013853	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
596154013854	N-terminal plug; other site
596154013855	ligand-binding site [chemical binding]; other site
596154013856	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
596154013857	CoenzymeA binding site [chemical binding]; other site
596154013858	subunit interaction site [polypeptide binding]; other site
596154013859	PHB binding site; other site
596154013860	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154013861	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
596154013862	putative DNA binding site [nucleotide binding]; other site
596154013863	putative Zn2+ binding site [ion binding]; other site
596154013864	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154013865	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154013866	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154013867	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154013868	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
596154013869	active site
596154013870	catalytic site [active]
596154013871	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
596154013872	active site 2 [active]
596154013873	active site 1 [active]
596154013874	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
596154013875	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
596154013876	acyl-activating enzyme (AAE) consensus motif; other site
596154013877	AMP binding site [chemical binding]; other site
596154013878	active site
596154013879	CoA binding site [chemical binding]; other site
596154013880	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
596154013881	Lumazine binding domain; Region: Lum_binding; pfam00677
596154013882	Lumazine binding domain; Region: Lum_binding; pfam00677
596154013883	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
596154013884	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
596154013885	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154013886	ATP binding site [chemical binding]; other site
596154013887	Mg2+ binding site [ion binding]; other site
596154013888	G-X-G motif; other site
596154013889	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
596154013890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154013891	active site
596154013892	phosphorylation site [posttranslational modification]
596154013893	intermolecular recognition site; other site
596154013894	dimerization interface [polypeptide binding]; other site
596154013895	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
596154013896	DNA binding site [nucleotide binding]
596154013897	Predicted membrane protein [Function unknown]; Region: COG3212
596154013898	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
596154013899	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
596154013900	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
596154013901	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
596154013902	FAD binding pocket [chemical binding]; other site
596154013903	FAD binding motif [chemical binding]; other site
596154013904	phosphate binding motif [ion binding]; other site
596154013905	beta-alpha-beta structure motif; other site
596154013906	NAD binding pocket [chemical binding]; other site
596154013907	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
596154013908	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
596154013909	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
596154013910	Flavodoxin; Region: Flavodoxin_1; pfam00258
596154013911	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
596154013912	FAD binding pocket [chemical binding]; other site
596154013913	conserved FAD binding motif [chemical binding]; other site
596154013914	phosphate binding motif [ion binding]; other site
596154013915	beta-alpha-beta structure motif; other site
596154013916	NAD binding pocket [chemical binding]; other site
596154013917	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
596154013918	ApbE family; Region: ApbE; pfam02424
596154013919	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
596154013920	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
596154013921	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
596154013922	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
596154013923	motif II; other site
596154013924	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
596154013925	Nitronate monooxygenase; Region: NMO; pfam03060
596154013926	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
596154013927	FMN binding site [chemical binding]; other site
596154013928	substrate binding site [chemical binding]; other site
596154013929	putative catalytic residue [active]
596154013930	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154013931	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154013932	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154013933	active site
596154013934	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
596154013935	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154013936	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154013937	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154013938	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154013939	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
596154013940	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
596154013941	NADP binding site [chemical binding]; other site
596154013942	dimer interface [polypeptide binding]; other site
596154013943	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
596154013944	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
596154013945	active site
596154013946	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154013947	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
596154013948	Transcriptional regulator [Transcription]; Region: IclR; COG1414
596154013949	Bacterial transcriptional regulator; Region: IclR; pfam01614
596154013950	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
596154013951	CoA-transferase family III; Region: CoA_transf_3; pfam02515
596154013952	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
596154013953	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154013954	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154013955	dimerization interface [polypeptide binding]; other site
596154013956	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
596154013957	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
596154013958	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
596154013959	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
596154013960	spermidine synthase; Provisional; Region: PRK03612
596154013961	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154013962	S-adenosylmethionine binding site [chemical binding]; other site
596154013963	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
596154013964	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
596154013965	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
596154013966	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
596154013967	Short C-terminal domain; Region: SHOCT; pfam09851
596154013968	Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834
596154013969	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
596154013970	Transcriptional regulator [Transcription]; Region: LysR; COG0583
596154013971	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154013972	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
596154013973	dimerization interface [polypeptide binding]; other site
596154013974	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
596154013975	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
596154013976	inhibitor-cofactor binding pocket; inhibition site
596154013977	pyridoxal 5'-phosphate binding site [chemical binding]; other site
596154013978	catalytic residue [active]
596154013979	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
596154013980	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
596154013981	tetrameric interface [polypeptide binding]; other site
596154013982	NAD binding site [chemical binding]; other site
596154013983	catalytic residues [active]
596154013984	MASE2 domain; Region: MASE2; pfam05230
596154013985	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154013986	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154013987	metal binding site [ion binding]; metal-binding site
596154013988	active site
596154013989	I-site; other site
596154013990	Transcriptional regulators [Transcription]; Region: FadR; COG2186
596154013991	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
596154013992	DNA-binding site [nucleotide binding]; DNA binding site
596154013993	FCD domain; Region: FCD; pfam07729
596154013994	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
596154013995	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
596154013996	putative ligand binding site [chemical binding]; other site
596154013997	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154013998	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
596154013999	TM-ABC transporter signature motif; other site
596154014000	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
596154014001	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
596154014002	TM-ABC transporter signature motif; other site
596154014003	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
596154014004	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
596154014005	Walker A/P-loop; other site
596154014006	ATP binding site [chemical binding]; other site
596154014007	Q-loop/lid; other site
596154014008	ABC transporter signature motif; other site
596154014009	Walker B; other site
596154014010	D-loop; other site
596154014011	H-loop/switch region; other site
596154014012	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
596154014013	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
596154014014	Walker A/P-loop; other site
596154014015	ATP binding site [chemical binding]; other site
596154014016	Q-loop/lid; other site
596154014017	ABC transporter signature motif; other site
596154014018	Walker B; other site
596154014019	D-loop; other site
596154014020	H-loop/switch region; other site
596154014021	allantoate amidohydrolase; Reviewed; Region: PRK12893
596154014022	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
596154014023	active site
596154014024	metal binding site [ion binding]; metal-binding site
596154014025	dimer interface [polypeptide binding]; other site
596154014026	Uncharacterized conserved protein [Function unknown]; Region: COG5476
596154014027	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
596154014028	MlrC C-terminus; Region: MlrC_C; pfam07171
596154014029	Malate dehydrogenase enzyme; Region: Malate_DH; pfam12434
596154014030	malic enzyme; Reviewed; Region: PRK12862
596154014031	Malic enzyme, N-terminal domain; Region: malic; pfam00390
596154014032	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
596154014033	putative NAD(P) binding site [chemical binding]; other site
596154014034	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
596154014035	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
596154014036	active site
596154014037	barstar interaction site; other site
596154014038	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
596154014039	putative RNAase interaction site [polypeptide binding]; other site
596154014040	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
596154014041	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
596154014042	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
596154014043	SurA N-terminal domain; Region: SurA_N; pfam09312
596154014044	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
596154014045	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
596154014046	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
596154014047	Organic solvent tolerance protein; Region: OstA_C; pfam04453
596154014048	Phosphotransferase enzyme family; Region: APH; pfam01636
596154014049	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
596154014050	substrate binding site [chemical binding]; other site
596154014051	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
596154014052	RNA methyltransferase, RsmE family; Region: TIGR00046
596154014053	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
596154014054	AAA domain; Region: AAA_23; pfam13476
596154014055	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
596154014056	ABC transporter signature motif; other site
596154014057	Walker B; other site
596154014058	D-loop; other site
596154014059	H-loop/switch region; other site
596154014060	hypothetical protein; Provisional; Region: PRK07907
596154014061	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
596154014062	metal binding site [ion binding]; metal-binding site
596154014063	putative dimer interface [polypeptide binding]; other site
596154014064	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
596154014065	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
596154014066	metal binding site [ion binding]; metal-binding site
596154014067	active site
596154014068	I-site; other site
596154014069	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
596154014070	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
596154014071	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
596154014072	Predicted membrane protein [Function unknown]; Region: COG2119
596154014073	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
596154014074	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
596154014075	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
596154014076	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
596154014077	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
596154014078	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
596154014079	short chain dehydrogenase; Provisional; Region: PRK07024
596154014080	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
596154014081	NAD(P) binding site [chemical binding]; other site
596154014082	active site
596154014083	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
596154014084	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
596154014085	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
596154014086	active site
596154014087	motif I; other site
596154014088	motif II; other site
596154014089	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
596154014090	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
596154014091	putative active site [active]
596154014092	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
596154014093	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
596154014094	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
596154014095	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
596154014096	TrkA-N domain; Region: TrkA_N; pfam02254
596154014097	TrkA-C domain; Region: TrkA_C; pfam02080
596154014098	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
596154014099	active site
596154014100	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
596154014101	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
596154014102	ligand binding site [chemical binding]; other site
596154014103	flexible hinge region; other site
596154014104	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
596154014105	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
596154014106	trmE is a tRNA modification GTPase; Region: trmE; cd04164
596154014107	G1 box; other site
596154014108	GTP/Mg2+ binding site [chemical binding]; other site
596154014109	Switch I region; other site
596154014110	G2 box; other site
596154014111	Switch II region; other site
596154014112	G3 box; other site
596154014113	G4 box; other site
596154014114	G5 box; other site
596154014115	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
596154014116	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
596154014117	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
596154014118	substrate binding pocket [chemical binding]; other site
596154014119	membrane-bound complex binding site; other site
596154014120	hinge residues; other site
596154014121	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
596154014122	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
596154014123	hydroxyglutarate oxidase; Provisional; Region: PRK11728
596154014124	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
596154014125	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
596154014126	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
596154014127	dimerization interface [polypeptide binding]; other site
596154014128	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
596154014129	aspartate racemase; Region: asp_race; TIGR00035
596154014130	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
596154014131	SxDxEG motif; other site
596154014132	active site
596154014133	metal binding site [ion binding]; metal-binding site
596154014134	homopentamer interface [polypeptide binding]; other site
596154014135	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
596154014136	homodimer interface [polypeptide binding]; other site
596154014137	homotetramer interface [polypeptide binding]; other site
596154014138	active site pocket [active]
596154014139	cleavage site
596154014140	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
596154014141	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
596154014142	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154014143	dimer interface [polypeptide binding]; other site
596154014144	conserved gate region; other site
596154014145	putative PBP binding loops; other site
596154014146	ABC-ATPase subunit interface; other site
596154014147	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
596154014148	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
596154014149	dimer interface [polypeptide binding]; other site
596154014150	conserved gate region; other site
596154014151	putative PBP binding loops; other site
596154014152	ABC-ATPase subunit interface; other site
596154014153	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
596154014154	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
596154014155	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
596154014156	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
596154014157	Walker A/P-loop; other site
596154014158	ATP binding site [chemical binding]; other site
596154014159	Q-loop/lid; other site
596154014160	ABC transporter signature motif; other site
596154014161	Walker B; other site
596154014162	D-loop; other site
596154014163	H-loop/switch region; other site
596154014164	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
596154014165	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
596154014166	Walker A/P-loop; other site
596154014167	ATP binding site [chemical binding]; other site
596154014168	Q-loop/lid; other site
596154014169	ABC transporter signature motif; other site
596154014170	Walker B; other site
596154014171	D-loop; other site
596154014172	H-loop/switch region; other site
596154014173	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
596154014174	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
596154014175	catalytic nucleophile [active]
596154014176	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
596154014177	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
596154014178	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
596154014179	putative active site [active]
596154014180	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
596154014181	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
596154014182	membrane protein insertase; Provisional; Region: PRK01318
596154014183	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
596154014184	hypothetical protein; Provisional; Region: PRK14389
596154014185	Ribonuclease P; Region: Ribonuclease_P; pfam00825
596154014186	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
596154014187	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
596154014188	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
596154014189	Walker A motif; other site
596154014190	ATP binding site [chemical binding]; other site
596154014191	Walker B motif; other site
596154014192	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
596154014193	TrwC relaxase; Region: TrwC; pfam08751
596154014194	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
596154014195	AAA domain; Region: AAA_30; pfam13604
596154014196	Family description; Region: UvrD_C_2; pfam13538
596154014197	YheO-like PAS domain; Region: PAS_6; pfam08348
596154014198	Domain of unknown function (DUF1805); Region: DUF1805; pfam08827
596154014199	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
596154014200	Histidine kinase; Region: HisKA_3; pfam07730
596154014201	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
596154014202	ATP binding site [chemical binding]; other site
596154014203	Mg2+ binding site [ion binding]; other site
596154014204	G-X-G motif; other site
596154014205	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
596154014206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
596154014207	active site
596154014208	phosphorylation site [posttranslational modification]
596154014209	intermolecular recognition site; other site
596154014210	dimerization interface [polypeptide binding]; other site
596154014211	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
596154014212	DNA binding residues [nucleotide binding]
596154014213	dimerization interface [polypeptide binding]; other site
596154014214	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
596154014215	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
596154014216	N-acetyl-D-glucosamine binding site [chemical binding]; other site
596154014217	catalytic residue [active]
596154014218	TraL protein; Region: TraL; cl06278
596154014219	TraE protein; Region: TraE; cl05060
596154014220	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
596154014221	TraK protein; Region: TraK; pfam06586
596154014222	conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729
596154014223	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
596154014224	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
596154014225	dimerization domain [polypeptide binding]; other site
596154014226	dimer interface [polypeptide binding]; other site
596154014227	catalytic residues [active]
596154014228	type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747
596154014229	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
596154014230	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
596154014231	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
596154014232	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
596154014233	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
596154014234	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
596154014235	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
596154014236	TraU protein; Region: TraU; pfam06834
596154014237	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673
596154014238	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
596154014239	conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876
596154014240	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
596154014241	F plasmid transfer operon protein; Region: TraF; pfam13728
596154014242	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
596154014243	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
596154014244	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
596154014245	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
596154014246	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
596154014247	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
596154014248	FIC domain binding interface [polypeptide binding]; other site
596154014249	Fic/DOC family; Region: Fic; cl00960
596154014250	Zeta toxin; Region: Zeta_toxin; pfam06414
596154014251	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
596154014252	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
596154014253	IHF dimer interface [polypeptide binding]; other site
596154014254	IHF - DNA interface [nucleotide binding]; other site
596154014255	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
596154014256	ligand binding site [chemical binding]; other site
596154014257	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
596154014258	catalytic motif [active]
596154014259	Catalytic residue [active]
596154014260	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
596154014261	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
596154014262	catalytic motif [active]
596154014263	Catalytic residue [active]
596154014264	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
596154014265	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
596154014266	active site
596154014267	metal binding site [ion binding]; metal-binding site
596154014268	interdomain interaction site; other site
596154014269	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
596154014270	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
596154014271	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
596154014272	P-loop; other site
596154014273	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
596154014274	Magnesium ion binding site [ion binding]; other site
596154014275	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
596154014276	Magnesium ion binding site [ion binding]; other site
596154014277	ParB-like nuclease domain; Region: ParBc; pfam02195
596154014278	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
596154014279	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
596154014280	Replication initiator protein A; Region: RPA; pfam10134
596154014281	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
596154014282	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
596154014283	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
596154014284	cofactor binding site; other site
596154014285	DNA binding site [nucleotide binding]
596154014286	substrate interaction site [chemical binding]; other site
596154014287	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
596154014288	PLD-like domain; Region: PLDc_2; pfam13091
596154014289	putative active site [active]
596154014290	catalytic site [active]
596154014291	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
596154014292	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
596154014293	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
596154014294	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
596154014295	HlyD family secretion protein; Region: HlyD_3; pfam13437
596154014296	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
596154014297	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
596154014298	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
596154014299	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
596154014300	dimer interface [polypeptide binding]; other site
596154014301	ssDNA binding site [nucleotide binding]; other site
596154014302	tetramer (dimer of dimers) interface [polypeptide binding]; other site
596154014303	Domain of unknown function (DUF932); Region: DUF932; pfam06067
596154014304	Domain of unknown function (DUF3560); Region: DUF3560; pfam12083
596154014305	BH3 interacting domain (BID); Region: BID; pfam06393
596154014306	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
596154014307	S-adenosylmethionine binding site [chemical binding]; other site
596154014308	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
596154014309	MPN+ (JAMM) motif; other site
596154014310	Zinc-binding site [ion binding]; other site
596154014311	multiple promoter invertase; Provisional; Region: mpi; PRK13413
596154014312	Resolvase, N terminal domain; Region: Resolvase; pfam00239
596154014313	catalytic residues [active]
596154014314	catalytic nucleophile [active]