-- dump date 20140618_193900 -- class Genbank::misc_feature -- table misc_feature_note -- id note 521098000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 521098000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 521098000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098000004 Walker A motif; other site 521098000005 ATP binding site [chemical binding]; other site 521098000006 Walker B motif; other site 521098000007 arginine finger; other site 521098000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 521098000009 DnaA box-binding interface [nucleotide binding]; other site 521098000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 521098000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 521098000012 putative DNA binding surface [nucleotide binding]; other site 521098000013 dimer interface [polypeptide binding]; other site 521098000014 beta-clamp/clamp loader binding surface; other site 521098000015 beta-clamp/translesion DNA polymerase binding surface; other site 521098000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521098000017 RNA binding surface [nucleotide binding]; other site 521098000018 recombination protein F; Reviewed; Region: recF; PRK00064 521098000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 521098000020 Walker A/P-loop; other site 521098000021 ATP binding site [chemical binding]; other site 521098000022 Q-loop/lid; other site 521098000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521098000024 ABC transporter signature motif; other site 521098000025 Walker B; other site 521098000026 D-loop; other site 521098000027 H-loop/switch region; other site 521098000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 521098000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098000030 ATP binding site [chemical binding]; other site 521098000031 Mg2+ binding site [ion binding]; other site 521098000032 G-X-G motif; other site 521098000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 521098000034 anchoring element; other site 521098000035 dimer interface [polypeptide binding]; other site 521098000036 ATP binding site [chemical binding]; other site 521098000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 521098000038 active site 521098000039 putative metal-binding site [ion binding]; other site 521098000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 521098000041 DNA gyrase subunit A; Validated; Region: PRK05560 521098000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 521098000043 CAP-like domain; other site 521098000044 active site 521098000045 primary dimer interface [polypeptide binding]; other site 521098000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521098000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521098000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521098000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521098000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521098000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521098000052 Predicted acetyltransferase [General function prediction only]; Region: COG3393 521098000053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 521098000054 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 521098000055 active site 521098000056 catalytic motif [active] 521098000057 Zn binding site [ion binding]; other site 521098000058 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 521098000059 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 521098000060 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 521098000061 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 521098000062 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 521098000063 active site 521098000064 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 521098000065 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 521098000066 active site 521098000067 multimer interface [polypeptide binding]; other site 521098000068 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 521098000069 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 521098000070 predicted active site [active] 521098000071 catalytic triad [active] 521098000072 seryl-tRNA synthetase; Provisional; Region: PRK05431 521098000073 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 521098000074 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 521098000075 dimer interface [polypeptide binding]; other site 521098000076 active site 521098000077 motif 1; other site 521098000078 motif 2; other site 521098000079 motif 3; other site 521098000080 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 521098000081 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 521098000082 Staphylococcal nuclease homologues; Region: SNc; smart00318 521098000083 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 521098000084 Catalytic site; other site 521098000085 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 521098000086 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 521098000087 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 521098000088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 521098000089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 521098000090 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 521098000091 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 521098000092 dimer interface [polypeptide binding]; other site 521098000093 active site 521098000094 CoA binding pocket [chemical binding]; other site 521098000095 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 521098000096 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 521098000097 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521098000098 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 521098000099 TrkA-N domain; Region: TrkA_N; pfam02254 521098000100 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 521098000101 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 521098000102 isocitrate lyase; Provisional; Region: PRK15063 521098000103 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 521098000104 tetramer interface [polypeptide binding]; other site 521098000105 active site 521098000106 Mg2+/Mn2+ binding site [ion binding]; other site 521098000107 H+ Antiporter protein; Region: 2A0121; TIGR00900 521098000108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098000109 putative substrate translocation pore; other site 521098000110 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 521098000111 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 521098000112 TM-ABC transporter signature motif; other site 521098000113 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 521098000114 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 521098000115 TM-ABC transporter signature motif; other site 521098000116 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 521098000117 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 521098000118 Walker A/P-loop; other site 521098000119 ATP binding site [chemical binding]; other site 521098000120 Q-loop/lid; other site 521098000121 ABC transporter signature motif; other site 521098000122 Walker B; other site 521098000123 D-loop; other site 521098000124 H-loop/switch region; other site 521098000125 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 521098000126 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 521098000127 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 521098000128 ligand binding site [chemical binding]; other site 521098000129 Isochorismatase family; Region: Isochorismatase; pfam00857 521098000130 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 521098000131 catalytic triad [active] 521098000132 conserved cis-peptide bond; other site 521098000133 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 521098000134 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 521098000135 active site 521098000136 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 521098000137 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 521098000138 Walker A/P-loop; other site 521098000139 ATP binding site [chemical binding]; other site 521098000140 Q-loop/lid; other site 521098000141 ABC transporter signature motif; other site 521098000142 Walker B; other site 521098000143 D-loop; other site 521098000144 H-loop/switch region; other site 521098000145 TOBE domain; Region: TOBE_2; pfam08402 521098000146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098000147 dimer interface [polypeptide binding]; other site 521098000148 conserved gate region; other site 521098000149 putative PBP binding loops; other site 521098000150 ABC-ATPase subunit interface; other site 521098000151 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 521098000152 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 521098000153 ABC-2 type transporter; Region: ABC2_membrane; cl17235 521098000154 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 521098000155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521098000156 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 521098000157 Walker A/P-loop; other site 521098000158 ATP binding site [chemical binding]; other site 521098000159 Q-loop/lid; other site 521098000160 ABC transporter signature motif; other site 521098000161 Walker B; other site 521098000162 D-loop; other site 521098000163 H-loop/switch region; other site 521098000164 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 521098000165 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521098000166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098000167 active site 521098000168 phosphorylation site [posttranslational modification] 521098000169 intermolecular recognition site; other site 521098000170 dimerization interface [polypeptide binding]; other site 521098000171 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521098000172 DNA binding site [nucleotide binding] 521098000173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521098000174 dimer interface [polypeptide binding]; other site 521098000175 phosphorylation site [posttranslational modification] 521098000176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098000177 ATP binding site [chemical binding]; other site 521098000178 Mg2+ binding site [ion binding]; other site 521098000179 G-X-G motif; other site 521098000180 LysE type translocator; Region: LysE; cl00565 521098000181 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 521098000182 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 521098000183 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521098000184 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521098000185 DNA binding site [nucleotide binding] 521098000186 domain linker motif; other site 521098000187 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 521098000188 ligand binding site [chemical binding]; other site 521098000189 dimerization interface [polypeptide binding]; other site 521098000190 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 521098000191 benzoate transport; Region: 2A0115; TIGR00895 521098000192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098000193 putative substrate translocation pore; other site 521098000194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098000195 putative substrate translocation pore; other site 521098000196 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 521098000197 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 521098000198 DNA binding residues [nucleotide binding] 521098000199 Phosphate transporter family; Region: PHO4; pfam01384 521098000200 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 521098000201 glycerol kinase; Provisional; Region: glpK; PRK00047 521098000202 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 521098000203 N- and C-terminal domain interface [polypeptide binding]; other site 521098000204 active site 521098000205 MgATP binding site [chemical binding]; other site 521098000206 catalytic site [active] 521098000207 metal binding site [ion binding]; metal-binding site 521098000208 glycerol binding site [chemical binding]; other site 521098000209 homotetramer interface [polypeptide binding]; other site 521098000210 homodimer interface [polypeptide binding]; other site 521098000211 FBP binding site [chemical binding]; other site 521098000212 protein IIAGlc interface [polypeptide binding]; other site 521098000213 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 521098000214 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 521098000215 peptidase domain interface [polypeptide binding]; other site 521098000216 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 521098000217 active site 521098000218 catalytic triad [active] 521098000219 calcium binding site [ion binding]; other site 521098000220 Transcriptional regulators [Transcription]; Region: GntR; COG1802 521098000221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521098000222 DNA-binding site [nucleotide binding]; DNA binding site 521098000223 FCD domain; Region: FCD; pfam07729 521098000224 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 521098000225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521098000226 NAD(P) binding site [chemical binding]; other site 521098000227 active site 521098000228 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 521098000229 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 521098000230 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 521098000231 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 521098000232 Na binding site [ion binding]; other site 521098000233 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 521098000234 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 521098000235 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521098000236 putative active site [active] 521098000237 heme pocket [chemical binding]; other site 521098000238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521098000239 dimer interface [polypeptide binding]; other site 521098000240 phosphorylation site [posttranslational modification] 521098000241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098000242 ATP binding site [chemical binding]; other site 521098000243 Mg2+ binding site [ion binding]; other site 521098000244 G-X-G motif; other site 521098000245 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 521098000246 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 521098000247 active site 521098000248 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 521098000249 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 521098000250 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 521098000251 catalytic site [active] 521098000252 G-X2-G-X-G-K; other site 521098000253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521098000254 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 521098000255 dimerization interface [polypeptide binding]; other site 521098000256 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521098000257 dimer interface [polypeptide binding]; other site 521098000258 phosphorylation site [posttranslational modification] 521098000259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098000260 ATP binding site [chemical binding]; other site 521098000261 Mg2+ binding site [ion binding]; other site 521098000262 G-X-G motif; other site 521098000263 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 521098000264 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 521098000265 short chain dehydrogenase; Provisional; Region: PRK06197 521098000266 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 521098000267 putative NAD(P) binding site [chemical binding]; other site 521098000268 active site 521098000269 thymidine kinase; Provisional; Region: PRK04296 521098000270 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 521098000271 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 521098000272 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 521098000273 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 521098000274 PLD-like domain; Region: PLDc_2; pfam13091 521098000275 putative active site [active] 521098000276 catalytic site [active] 521098000277 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128 521098000278 PLD-like domain; Region: PLDc_2; pfam13091 521098000279 putative active site [active] 521098000280 putative catalytic site [active] 521098000281 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 521098000282 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 521098000283 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 521098000284 active site 521098000285 catalytic site [active] 521098000286 metal binding site [ion binding]; metal-binding site 521098000287 dimer interface [polypeptide binding]; other site 521098000288 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 521098000289 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 521098000290 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 521098000291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098000292 dimer interface [polypeptide binding]; other site 521098000293 conserved gate region; other site 521098000294 putative PBP binding loops; other site 521098000295 ABC-ATPase subunit interface; other site 521098000296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098000297 dimer interface [polypeptide binding]; other site 521098000298 conserved gate region; other site 521098000299 putative PBP binding loops; other site 521098000300 ABC-ATPase subunit interface; other site 521098000301 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 521098000302 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 521098000303 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 521098000304 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 521098000305 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 521098000306 putative substrate binding pocket [chemical binding]; other site 521098000307 AC domain interface; other site 521098000308 catalytic triad [active] 521098000309 AB domain interface; other site 521098000310 interchain disulfide; other site 521098000311 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 521098000312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 521098000313 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 521098000314 Predicted membrane protein [Function unknown]; Region: COG1511 521098000315 Predicted membrane protein [Function unknown]; Region: COG1511 521098000316 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 521098000317 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 521098000318 Family description; Region: UvrD_C_2; pfam13538 521098000319 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521098000320 catalytic core [active] 521098000321 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 521098000322 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 521098000323 active site 521098000324 dimer interface [polypeptide binding]; other site 521098000325 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 521098000326 dimer interface [polypeptide binding]; other site 521098000327 active site 521098000328 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 521098000329 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 521098000330 nucleotide binding site [chemical binding]; other site 521098000331 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 521098000332 active site 521098000333 butyrate kinase; Provisional; Region: PRK03011 521098000334 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 521098000335 MMPL family; Region: MMPL; pfam03176 521098000336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 521098000337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 521098000338 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 521098000339 Cupin domain; Region: Cupin_2; pfam07883 521098000340 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 521098000341 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 521098000342 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 521098000343 dimer interface [polypeptide binding]; other site 521098000344 active site 521098000345 catalytic residue [active] 521098000346 metal binding site [ion binding]; metal-binding site 521098000347 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 521098000348 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 521098000349 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 521098000350 intersubunit interface [polypeptide binding]; other site 521098000351 active site 521098000352 Zn2+ binding site [ion binding]; other site 521098000353 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 521098000354 active site 521098000355 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 521098000356 dimer interface [polypeptide binding]; other site 521098000357 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 521098000358 Ligand Binding Site [chemical binding]; other site 521098000359 Molecular Tunnel; other site 521098000360 Late competence development protein ComFB; Region: ComFB; pfam10719 521098000361 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 521098000362 nucleoside/Zn binding site; other site 521098000363 dimer interface [polypeptide binding]; other site 521098000364 catalytic motif [active] 521098000365 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 521098000366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521098000367 dimer interface [polypeptide binding]; other site 521098000368 phosphorylation site [posttranslational modification] 521098000369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098000370 ATP binding site [chemical binding]; other site 521098000371 Mg2+ binding site [ion binding]; other site 521098000372 G-X-G motif; other site 521098000373 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 521098000374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098000375 Walker A motif; other site 521098000376 ATP binding site [chemical binding]; other site 521098000377 Walker B motif; other site 521098000378 arginine finger; other site 521098000379 hypothetical protein; Validated; Region: PRK00153 521098000380 recombination protein RecR; Reviewed; Region: recR; PRK00076 521098000381 RecR protein; Region: RecR; pfam02132 521098000382 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 521098000383 putative active site [active] 521098000384 putative metal-binding site [ion binding]; other site 521098000385 tetramer interface [polypeptide binding]; other site 521098000386 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 521098000387 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 521098000388 Transcriptional regulators [Transcription]; Region: GntR; COG1802 521098000389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521098000390 DNA-binding site [nucleotide binding]; DNA binding site 521098000391 FCD domain; Region: FCD; pfam07729 521098000392 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 521098000393 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 521098000394 Transposase, Mutator family; Region: Transposase_mut; pfam00872 521098000395 MULE transposase domain; Region: MULE; pfam10551 521098000396 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 521098000397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098000398 dimer interface [polypeptide binding]; other site 521098000399 conserved gate region; other site 521098000400 ABC-ATPase subunit interface; other site 521098000401 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 521098000402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098000403 dimer interface [polypeptide binding]; other site 521098000404 conserved gate region; other site 521098000405 putative PBP binding loops; other site 521098000406 ABC-ATPase subunit interface; other site 521098000407 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 521098000408 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 521098000409 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 521098000410 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 521098000411 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 521098000412 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521098000413 catalytic residue [active] 521098000414 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 521098000415 thymidylate kinase; Validated; Region: tmk; PRK00698 521098000416 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 521098000417 TMP-binding site; other site 521098000418 ATP-binding site [chemical binding]; other site 521098000419 Protein of unknown function (DUF970); Region: DUF970; pfam06153 521098000420 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 521098000421 DNA polymerase III subunit delta'; Validated; Region: PRK08485 521098000422 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 521098000423 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 521098000424 Predicted methyltransferases [General function prediction only]; Region: COG0313 521098000425 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 521098000426 putative SAM binding site [chemical binding]; other site 521098000427 putative homodimer interface [polypeptide binding]; other site 521098000428 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 521098000429 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 521098000430 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 521098000431 active site 521098000432 HIGH motif; other site 521098000433 KMSKS motif; other site 521098000434 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 521098000435 tRNA binding surface [nucleotide binding]; other site 521098000436 anticodon binding site; other site 521098000437 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 521098000438 dimer interface [polypeptide binding]; other site 521098000439 putative tRNA-binding site [nucleotide binding]; other site 521098000440 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 521098000441 active site 521098000442 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 521098000443 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 521098000444 putative active site [active] 521098000445 putative metal binding site [ion binding]; other site 521098000446 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 521098000447 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 521098000448 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 521098000449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 521098000450 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 521098000451 active site 521098000452 diiron metal binding site [ion binding]; other site 521098000453 PGAP1-like protein; Region: PGAP1; pfam07819 521098000454 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470 521098000455 GAF domain; Region: GAF; pfam01590 521098000456 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 521098000457 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 521098000458 DNA binding residues [nucleotide binding] 521098000459 dimerization interface [polypeptide binding]; other site 521098000460 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 521098000461 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 521098000462 Malic enzyme, N-terminal domain; Region: malic; pfam00390 521098000463 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 521098000464 putative NAD(P) binding site [chemical binding]; other site 521098000465 SCP-2 sterol transfer family; Region: SCP2; pfam02036 521098000466 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 521098000467 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 521098000468 acyl-activating enzyme (AAE) consensus motif; other site 521098000469 putative AMP binding site [chemical binding]; other site 521098000470 putative active site [active] 521098000471 putative CoA binding site [chemical binding]; other site 521098000472 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 521098000473 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 521098000474 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 521098000475 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 521098000476 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 521098000477 active site 521098000478 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 521098000479 enoyl-CoA hydratase; Provisional; Region: PRK07657 521098000480 substrate binding site [chemical binding]; other site 521098000481 oxyanion hole (OAH) forming residues; other site 521098000482 trimer interface [polypeptide binding]; other site 521098000483 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 521098000484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521098000485 NAD(P) binding site [chemical binding]; other site 521098000486 active site 521098000487 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 521098000488 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 521098000489 dimer interface [polypeptide binding]; other site 521098000490 active site 521098000491 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 521098000492 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 521098000493 active site 521098000494 catalytic site [active] 521098000495 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 521098000496 ABC1 family; Region: ABC1; cl17513 521098000497 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 521098000498 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 521098000499 NAD(P) binding site [chemical binding]; other site 521098000500 catalytic residues [active] 521098000501 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 521098000502 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 521098000503 active site 521098000504 NAD binding site [chemical binding]; other site 521098000505 metal binding site [ion binding]; metal-binding site 521098000506 S-layer homology domain; Region: SLH; pfam00395 521098000507 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 521098000508 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 521098000509 active site 521098000510 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 521098000511 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 521098000512 homotetramer interface [polypeptide binding]; other site 521098000513 NAD(P) binding site [chemical binding]; other site 521098000514 homodimer interface [polypeptide binding]; other site 521098000515 active site 521098000516 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 521098000517 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521098000518 NAD(P) binding site [chemical binding]; other site 521098000519 active site 521098000520 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 521098000521 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 521098000522 FAD binding site [chemical binding]; other site 521098000523 substrate binding site [chemical binding]; other site 521098000524 catalytic base [active] 521098000525 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 521098000526 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 521098000527 dimer interface [polypeptide binding]; other site 521098000528 acyl-activating enzyme (AAE) consensus motif; other site 521098000529 putative active site [active] 521098000530 AMP binding site [chemical binding]; other site 521098000531 putative CoA binding site [chemical binding]; other site 521098000532 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 521098000533 active site 521098000534 catalytic site [active] 521098000535 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 521098000536 active site 2 [active] 521098000537 active site 1 [active] 521098000538 Transcriptional regulator [Transcription]; Region: IclR; COG1414 521098000539 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521098000540 putative DNA binding site [nucleotide binding]; other site 521098000541 putative Zn2+ binding site [ion binding]; other site 521098000542 Bacterial transcriptional regulator; Region: IclR; pfam01614 521098000543 Phosphotransferase enzyme family; Region: APH; pfam01636 521098000544 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 521098000545 putative active site [active] 521098000546 putative substrate binding site [chemical binding]; other site 521098000547 ATP binding site [chemical binding]; other site 521098000548 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521098000549 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 521098000550 active site 521098000551 metal binding site [ion binding]; metal-binding site 521098000552 Protein of unknown function (DUF458); Region: DUF458; pfam04308 521098000553 YabG peptidase U57; Region: Peptidase_U57; pfam05582 521098000554 Helix-turn-helix domain; Region: HTH_28; pfam13518 521098000555 Winged helix-turn helix; Region: HTH_29; pfam13551 521098000556 Homeodomain-like domain; Region: HTH_32; pfam13565 521098000557 Integrase core domain; Region: rve; pfam00665 521098000558 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 521098000559 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 521098000560 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 521098000561 proposed catalytic triad [active] 521098000562 active site nucleophile [active] 521098000563 cyanophycin synthetase; Provisional; Region: PRK14016 521098000564 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 521098000565 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521098000566 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 521098000567 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 521098000568 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 521098000569 pur operon repressor; Provisional; Region: PRK09213 521098000570 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 521098000571 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521098000572 active site 521098000573 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 521098000574 homotrimer interaction site [polypeptide binding]; other site 521098000575 putative active site [active] 521098000576 regulatory protein SpoVG; Reviewed; Region: PRK13259 521098000577 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 521098000578 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 521098000579 Substrate binding site; other site 521098000580 Mg++ binding site; other site 521098000581 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 521098000582 active site 521098000583 substrate binding site [chemical binding]; other site 521098000584 CoA binding site [chemical binding]; other site 521098000585 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 521098000586 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 521098000587 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521098000588 active site 521098000589 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 521098000590 putative active site [active] 521098000591 catalytic residue [active] 521098000592 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 521098000593 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 521098000594 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 521098000595 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521098000596 ATP binding site [chemical binding]; other site 521098000597 putative Mg++ binding site [ion binding]; other site 521098000598 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521098000599 nucleotide binding region [chemical binding]; other site 521098000600 ATP-binding site [chemical binding]; other site 521098000601 TRCF domain; Region: TRCF; pfam03461 521098000602 stage V sporulation protein T; Region: spore_V_T; TIGR02851 521098000603 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 521098000604 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 521098000605 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 521098000606 active site 521098000607 homodimer interface [polypeptide binding]; other site 521098000608 SAM binding site [chemical binding]; other site 521098000609 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 521098000610 homodimer interface [polypeptide binding]; other site 521098000611 metal binding site [ion binding]; metal-binding site 521098000612 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 521098000613 homodimer interface [polypeptide binding]; other site 521098000614 active site 521098000615 putative chemical substrate binding site [chemical binding]; other site 521098000616 metal binding site [ion binding]; metal-binding site 521098000617 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 521098000618 IHF - DNA interface [nucleotide binding]; other site 521098000619 IHF dimer interface [polypeptide binding]; other site 521098000620 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521098000621 RNA binding surface [nucleotide binding]; other site 521098000622 YabP family; Region: YabP; pfam07873 521098000623 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578 521098000624 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 521098000625 Septum formation initiator; Region: DivIC; pfam04977 521098000626 hypothetical protein; Provisional; Region: PRK08582 521098000627 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 521098000628 RNA binding site [nucleotide binding]; other site 521098000629 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 521098000630 catalytic motif [active] 521098000631 Zn binding site [ion binding]; other site 521098000632 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 521098000633 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 521098000634 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521098000635 metal ion-dependent adhesion site (MIDAS); other site 521098000636 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 521098000637 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 521098000638 active site 521098000639 ATP binding site [chemical binding]; other site 521098000640 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 521098000641 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 521098000642 Ligand Binding Site [chemical binding]; other site 521098000643 TilS substrate binding domain; Region: TilS; pfam09179 521098000644 TilS substrate C-terminal domain; Region: TilS_C; smart00977 521098000645 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521098000646 active site 521098000647 FtsH Extracellular; Region: FtsH_ext; pfam06480 521098000648 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 521098000649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098000650 Walker A motif; other site 521098000651 ATP binding site [chemical binding]; other site 521098000652 Walker B motif; other site 521098000653 arginine finger; other site 521098000654 Peptidase family M41; Region: Peptidase_M41; pfam01434 521098000655 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 521098000656 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521098000657 Zn2+ binding site [ion binding]; other site 521098000658 Mg2+ binding site [ion binding]; other site 521098000659 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 521098000660 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 521098000661 dimerization interface [polypeptide binding]; other site 521098000662 domain crossover interface; other site 521098000663 redox-dependent activation switch; other site 521098000664 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 521098000665 dihydropteroate synthase; Region: DHPS; TIGR01496 521098000666 substrate binding pocket [chemical binding]; other site 521098000667 dimer interface [polypeptide binding]; other site 521098000668 inhibitor binding site; inhibition site 521098000669 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 521098000670 catalytic center binding site [active] 521098000671 ATP binding site [chemical binding]; other site 521098000672 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521098000673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098000674 non-specific DNA binding site [nucleotide binding]; other site 521098000675 salt bridge; other site 521098000676 sequence-specific DNA binding site [nucleotide binding]; other site 521098000677 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 521098000678 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 521098000679 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 521098000680 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 521098000681 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 521098000682 dimer interface [polypeptide binding]; other site 521098000683 putative anticodon binding site; other site 521098000684 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 521098000685 motif 1; other site 521098000686 active site 521098000687 motif 2; other site 521098000688 motif 3; other site 521098000689 DinB family; Region: DinB; cl17821 521098000690 DinB superfamily; Region: DinB_2; pfam12867 521098000691 Bacitracin resistance protein BacA; Region: BacA; pfam02673 521098000692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098000693 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521098000694 putative substrate translocation pore; other site 521098000695 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 521098000696 EamA-like transporter family; Region: EamA; pfam00892 521098000697 EamA-like transporter family; Region: EamA; pfam00892 521098000698 VanZ like family; Region: VanZ; cl01971 521098000699 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 521098000700 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 521098000701 putative NAD(P) binding site [chemical binding]; other site 521098000702 putative active site [active] 521098000703 aspartate aminotransferase; Provisional; Region: PRK07681 521098000704 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521098000705 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098000706 homodimer interface [polypeptide binding]; other site 521098000707 catalytic residue [active] 521098000708 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 521098000709 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 521098000710 active site 521098000711 substrate binding site [chemical binding]; other site 521098000712 cosubstrate binding site; other site 521098000713 catalytic site [active] 521098000714 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 521098000715 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 521098000716 NAD(P) binding site [chemical binding]; other site 521098000717 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 521098000718 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 521098000719 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 521098000720 active site 521098000721 P-loop; other site 521098000722 phosphorylation site [posttranslational modification] 521098000723 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 521098000724 HTH domain; Region: HTH_11; pfam08279 521098000725 PRD domain; Region: PRD; pfam00874 521098000726 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 521098000727 active site 521098000728 P-loop; other site 521098000729 phosphorylation site [posttranslational modification] 521098000730 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 521098000731 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521098000732 active site 521098000733 phosphorylation site [posttranslational modification] 521098000734 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 521098000735 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 521098000736 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 521098000737 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 521098000738 dimerization domain swap beta strand [polypeptide binding]; other site 521098000739 regulatory protein interface [polypeptide binding]; other site 521098000740 active site 521098000741 regulatory phosphorylation site [posttranslational modification]; other site 521098000742 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 521098000743 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 521098000744 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 521098000745 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 521098000746 RNA polymerase sigma factor; Provisional; Region: PRK12519 521098000747 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521098000748 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521098000749 DNA binding residues [nucleotide binding] 521098000750 Putative zinc-finger; Region: zf-HC2; pfam13490 521098000751 Anti-sigma-K factor rskA; Region: RskA; pfam10099 521098000752 amidase; Provisional; Region: PRK06529 521098000753 Amidase; Region: Amidase; pfam01425 521098000754 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521098000755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521098000756 Walker A/P-loop; other site 521098000757 ATP binding site [chemical binding]; other site 521098000758 Q-loop/lid; other site 521098000759 ABC transporter signature motif; other site 521098000760 Walker B; other site 521098000761 D-loop; other site 521098000762 H-loop/switch region; other site 521098000763 Cobalt transport protein; Region: CbiQ; cl00463 521098000764 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 521098000765 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521098000766 Walker A/P-loop; other site 521098000767 ATP binding site [chemical binding]; other site 521098000768 Q-loop/lid; other site 521098000769 ABC transporter signature motif; other site 521098000770 Walker B; other site 521098000771 D-loop; other site 521098000772 H-loop/switch region; other site 521098000773 BioY family; Region: BioY; pfam02632 521098000774 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 521098000775 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 521098000776 metal binding site [ion binding]; metal-binding site 521098000777 active site 521098000778 I-site; other site 521098000779 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 521098000780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098000781 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521098000782 putative substrate translocation pore; other site 521098000783 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 521098000784 active site residue [active] 521098000785 Tannase and feruloyl esterase; Region: Tannase; pfam07519 521098000786 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 521098000787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521098000788 NAD(P) binding site [chemical binding]; other site 521098000789 active site 521098000790 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 521098000791 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521098000792 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 521098000793 CrcB-like protein; Region: CRCB; pfam02537 521098000794 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 521098000795 Predicted membrane protein [Function unknown]; Region: COG2246 521098000796 GtrA-like protein; Region: GtrA; pfam04138 521098000797 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 521098000798 substrate binding site [chemical binding]; other site 521098000799 THF binding site; other site 521098000800 zinc-binding site [ion binding]; other site 521098000801 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 521098000802 peptidase domain interface [polypeptide binding]; other site 521098000803 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 521098000804 active site 521098000805 catalytic triad [active] 521098000806 calcium binding site [ion binding]; other site 521098000807 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 521098000808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098000809 active site 521098000810 phosphorylation site [posttranslational modification] 521098000811 intermolecular recognition site; other site 521098000812 dimerization interface [polypeptide binding]; other site 521098000813 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521098000814 DNA binding site [nucleotide binding] 521098000815 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 521098000816 GAF domain; Region: GAF_3; pfam13492 521098000817 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521098000818 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521098000819 dimer interface [polypeptide binding]; other site 521098000820 phosphorylation site [posttranslational modification] 521098000821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098000822 ATP binding site [chemical binding]; other site 521098000823 Mg2+ binding site [ion binding]; other site 521098000824 G-X-G motif; other site 521098000825 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 521098000826 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 521098000827 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521098000828 Soluble P-type ATPase [General function prediction only]; Region: COG4087 521098000829 K+-transporting ATPase, c chain; Region: KdpC; cl00944 521098000830 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 521098000831 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 521098000832 Ligand Binding Site [chemical binding]; other site 521098000833 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 521098000834 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 521098000835 Ligand Binding Site [chemical binding]; other site 521098000836 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 521098000837 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 521098000838 NodB motif; other site 521098000839 active site 521098000840 catalytic site [active] 521098000841 metal binding site [ion binding]; metal-binding site 521098000842 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521098000843 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521098000844 active site 521098000845 catalytic tetrad [active] 521098000846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098000847 putative substrate translocation pore; other site 521098000848 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 521098000849 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 521098000850 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521098000851 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 521098000852 active site 521098000853 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 521098000854 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 521098000855 putative ligand binding site [chemical binding]; other site 521098000856 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 521098000857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521098000858 Walker A/P-loop; other site 521098000859 ATP binding site [chemical binding]; other site 521098000860 Q-loop/lid; other site 521098000861 ABC transporter signature motif; other site 521098000862 Walker B; other site 521098000863 D-loop; other site 521098000864 H-loop/switch region; other site 521098000865 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 521098000866 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 521098000867 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 521098000868 TM-ABC transporter signature motif; other site 521098000869 2-isopropylmalate synthase; Validated; Region: PRK03739 521098000870 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 521098000871 active site 521098000872 catalytic residues [active] 521098000873 metal binding site [ion binding]; metal-binding site 521098000874 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 521098000875 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 521098000876 catalytic residues [active] 521098000877 dimer interface [polypeptide binding]; other site 521098000878 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 521098000879 nucleotide binding site/active site [active] 521098000880 HIT family signature motif; other site 521098000881 catalytic residue [active] 521098000882 Uncharacterized conserved protein [Function unknown]; Region: COG1739 521098000883 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 521098000884 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 521098000885 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 521098000886 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 521098000887 Bacterial sugar transferase; Region: Bac_transf; pfam02397 521098000888 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 521098000889 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521098000890 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 521098000891 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 521098000892 putative ADP-binding pocket [chemical binding]; other site 521098000893 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 521098000894 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 521098000895 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 521098000896 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 521098000897 Walker A/P-loop; other site 521098000898 ATP binding site [chemical binding]; other site 521098000899 Q-loop/lid; other site 521098000900 ABC transporter signature motif; other site 521098000901 Walker B; other site 521098000902 D-loop; other site 521098000903 H-loop/switch region; other site 521098000904 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 521098000905 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521098000906 Transposase [DNA replication, recombination, and repair]; Region: COG5421 521098000907 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 521098000908 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 521098000909 active site 521098000910 metal binding site [ion binding]; metal-binding site 521098000911 DNA binding site [nucleotide binding] 521098000912 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 521098000913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521098000914 AAA domain; Region: AAA_23; pfam13476 521098000915 Walker A/P-loop; other site 521098000916 ATP binding site [chemical binding]; other site 521098000917 Q-loop/lid; other site 521098000918 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 521098000919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521098000920 Q-loop/lid; other site 521098000921 ABC transporter signature motif; other site 521098000922 Walker B; other site 521098000923 D-loop; other site 521098000924 H-loop/switch region; other site 521098000925 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 521098000926 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 521098000927 metal-binding site [ion binding] 521098000928 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 521098000929 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 521098000930 metal-binding site [ion binding] 521098000931 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521098000932 Soluble P-type ATPase [General function prediction only]; Region: COG4087 521098000933 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 521098000934 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521098000935 acyl-activating enzyme (AAE) consensus motif; other site 521098000936 AMP binding site [chemical binding]; other site 521098000937 active site 521098000938 CoA binding site [chemical binding]; other site 521098000939 Putative zinc-finger; Region: zf-HC2; pfam13490 521098000940 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 521098000941 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521098000942 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521098000943 DNA binding residues [nucleotide binding] 521098000944 Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292 521098000945 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 521098000946 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 521098000947 Moco binding site; other site 521098000948 metal coordination site [ion binding]; other site 521098000949 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 521098000950 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 521098000951 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 521098000952 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521098000953 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521098000954 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521098000955 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 521098000956 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521098000957 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 521098000958 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 521098000959 TPR repeat; Region: TPR_11; pfam13414 521098000960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521098000961 binding surface 521098000962 TPR motif; other site 521098000963 Tetratricopeptide repeat; Region: TPR_12; pfam13424 521098000964 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 521098000965 tetramerization interface [polypeptide binding]; other site 521098000966 active site 521098000967 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 521098000968 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 521098000969 catalytic motif [active] 521098000970 Catalytic residue [active] 521098000971 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 521098000972 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 521098000973 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 521098000974 Walker A motif; other site 521098000975 ATP binding site [chemical binding]; other site 521098000976 Walker B motif; other site 521098000977 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 521098000978 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521098000979 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521098000980 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 521098000981 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 521098000982 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 521098000983 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 521098000984 Pilus assembly protein, PilO; Region: PilO; cl01234 521098000985 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 521098000986 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 521098000987 Walker A motif; other site 521098000988 ATP binding site [chemical binding]; other site 521098000989 Walker B motif; other site 521098000990 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 521098000991 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 521098000992 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 521098000993 DEAD-like helicases superfamily; Region: DEXDc; smart00487 521098000994 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521098000995 ATP binding site [chemical binding]; other site 521098000996 putative Mg++ binding site [ion binding]; other site 521098000997 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521098000998 nucleotide binding region [chemical binding]; other site 521098000999 ATP-binding site [chemical binding]; other site 521098001000 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 521098001001 PAS fold; Region: PAS; pfam00989 521098001002 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521098001003 putative active site [active] 521098001004 heme pocket [chemical binding]; other site 521098001005 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 521098001006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098001007 Walker A motif; other site 521098001008 ATP binding site [chemical binding]; other site 521098001009 Walker B motif; other site 521098001010 arginine finger; other site 521098001011 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 521098001012 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 521098001013 inhibitor-cofactor binding pocket; inhibition site 521098001014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098001015 catalytic residue [active] 521098001016 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 521098001017 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 521098001018 NAD(P) binding site [chemical binding]; other site 521098001019 catalytic residues [active] 521098001020 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 521098001021 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 521098001022 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 521098001023 active site 521098001024 Arginase family; Region: Arginase; cd09989 521098001025 agmatinase; Region: agmatinase; TIGR01230 521098001026 active site 521098001027 Mn binding site [ion binding]; other site 521098001028 oligomer interface [polypeptide binding]; other site 521098001029 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 521098001030 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 521098001031 inhibitor-cofactor binding pocket; inhibition site 521098001032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098001033 catalytic residue [active] 521098001034 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 521098001035 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 521098001036 Glutamate binding site [chemical binding]; other site 521098001037 homodimer interface [polypeptide binding]; other site 521098001038 NAD binding site [chemical binding]; other site 521098001039 catalytic residues [active] 521098001040 PAS fold; Region: PAS_4; pfam08448 521098001041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 521098001042 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 521098001043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098001044 Walker A motif; other site 521098001045 ATP binding site [chemical binding]; other site 521098001046 Walker B motif; other site 521098001047 arginine finger; other site 521098001048 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 521098001049 S-methylmethionine transporter; Provisional; Region: PRK11387 521098001050 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 521098001051 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 521098001052 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 521098001053 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 521098001054 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 521098001055 short chain dehydrogenase; Provisional; Region: PRK06701 521098001056 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 521098001057 NAD binding site [chemical binding]; other site 521098001058 metal binding site [ion binding]; metal-binding site 521098001059 active site 521098001060 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 521098001061 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 521098001062 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 521098001063 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 521098001064 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 521098001065 benzoate transport; Region: 2A0115; TIGR00895 521098001066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098001067 putative substrate translocation pore; other site 521098001068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521098001069 DNA-binding site [nucleotide binding]; DNA binding site 521098001070 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 521098001071 FCD domain; Region: FCD; pfam07729 521098001072 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 521098001073 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 521098001074 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 521098001075 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 521098001076 NAD binding site [chemical binding]; other site 521098001077 catalytic residues [active] 521098001078 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 521098001079 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 521098001080 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 521098001081 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 521098001082 tetramer interface [polypeptide binding]; other site 521098001083 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 521098001084 tetramer interface [polypeptide binding]; other site 521098001085 active site 521098001086 metal binding site [ion binding]; metal-binding site 521098001087 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 521098001088 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 521098001089 dimer interface [polypeptide binding]; other site 521098001090 active site 521098001091 catalytic residue [active] 521098001092 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 521098001093 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 521098001094 tetramer interface [polypeptide binding]; other site 521098001095 heme binding pocket [chemical binding]; other site 521098001096 NADPH binding site [chemical binding]; other site 521098001097 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 521098001098 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 521098001099 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 521098001100 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 521098001101 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 521098001102 Transglycosylase; Region: Transgly; pfam00912 521098001103 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 521098001104 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 521098001105 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 521098001106 Interdomain contacts; other site 521098001107 Cytokine receptor motif; other site 521098001108 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 521098001109 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521098001110 active site 521098001111 Cupin domain; Region: Cupin_2; cl17218 521098001112 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 521098001113 catalytic residues [active] 521098001114 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 521098001115 putative active site [active] 521098001116 putative metal binding site [ion binding]; other site 521098001117 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 521098001118 active site 521098001119 Membrane protein of unknown function; Region: DUF360; pfam04020 521098001120 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 521098001121 putative carbohydrate kinase; Provisional; Region: PRK10565 521098001122 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 521098001123 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 521098001124 putative substrate binding site [chemical binding]; other site 521098001125 putative ATP binding site [chemical binding]; other site 521098001126 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 521098001127 alanine racemase; Reviewed; Region: alr; PRK00053 521098001128 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 521098001129 active site 521098001130 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521098001131 dimer interface [polypeptide binding]; other site 521098001132 substrate binding site [chemical binding]; other site 521098001133 catalytic residues [active] 521098001134 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 521098001135 PemK-like protein; Region: PemK; pfam02452 521098001136 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 521098001137 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 521098001138 homotetramer interface [polypeptide binding]; other site 521098001139 ligand binding site [chemical binding]; other site 521098001140 catalytic site [active] 521098001141 NAD binding site [chemical binding]; other site 521098001142 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 521098001143 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 521098001144 catalytic triad [active] 521098001145 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 521098001146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 521098001147 dimerization interface [polypeptide binding]; other site 521098001148 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 521098001149 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521098001150 Zn2+ binding site [ion binding]; other site 521098001151 Mg2+ binding site [ion binding]; other site 521098001152 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 521098001153 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 521098001154 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 521098001155 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 521098001156 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 521098001157 thiamine monophosphate kinase; Provisional; Region: PRK05731 521098001158 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 521098001159 ATP binding site [chemical binding]; other site 521098001160 dimerization interface [polypeptide binding]; other site 521098001161 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 521098001162 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 521098001163 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 521098001164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521098001165 Coenzyme A binding pocket [chemical binding]; other site 521098001166 UGMP family protein; Validated; Region: PRK09604 521098001167 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 521098001168 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 521098001169 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521098001170 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521098001171 ABC transporter; Region: ABC_tran_2; pfam12848 521098001172 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521098001173 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 521098001174 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 521098001175 active site 521098001176 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 521098001177 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 521098001178 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 521098001179 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 521098001180 GTP binding site; other site 521098001181 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 521098001182 putative MPT binding site; other site 521098001183 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521098001184 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 521098001185 oligomerisation interface [polypeptide binding]; other site 521098001186 mobile loop; other site 521098001187 roof hairpin; other site 521098001188 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 521098001189 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 521098001190 ring oligomerisation interface [polypeptide binding]; other site 521098001191 ATP/Mg binding site [chemical binding]; other site 521098001192 stacking interactions; other site 521098001193 hinge regions; other site 521098001194 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 521098001195 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 521098001196 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521098001197 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 521098001198 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 521098001199 active site residue [active] 521098001200 PAS domain S-box; Region: sensory_box; TIGR00229 521098001201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521098001202 putative active site [active] 521098001203 heme pocket [chemical binding]; other site 521098001204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 521098001205 Histidine kinase; Region: HisKA_3; pfam07730 521098001206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098001207 ATP binding site [chemical binding]; other site 521098001208 Mg2+ binding site [ion binding]; other site 521098001209 G-X-G motif; other site 521098001210 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 521098001211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098001212 active site 521098001213 phosphorylation site [posttranslational modification] 521098001214 intermolecular recognition site; other site 521098001215 dimerization interface [polypeptide binding]; other site 521098001216 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 521098001217 DNA binding residues [nucleotide binding] 521098001218 dimerization interface [polypeptide binding]; other site 521098001219 MoxR-like ATPases [General function prediction only]; Region: COG0714 521098001220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098001221 Walker A motif; other site 521098001222 ATP binding site [chemical binding]; other site 521098001223 Walker B motif; other site 521098001224 arginine finger; other site 521098001225 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 521098001226 Protein of unknown function DUF58; Region: DUF58; pfam01882 521098001227 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 521098001228 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 521098001229 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 521098001230 GMP synthase; Reviewed; Region: guaA; PRK00074 521098001231 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 521098001232 AMP/PPi binding site [chemical binding]; other site 521098001233 candidate oxyanion hole; other site 521098001234 catalytic triad [active] 521098001235 potential glutamine specificity residues [chemical binding]; other site 521098001236 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 521098001237 ATP Binding subdomain [chemical binding]; other site 521098001238 Ligand Binding sites [chemical binding]; other site 521098001239 Dimerization subdomain; other site 521098001240 adenylosuccinate lyase; Provisional; Region: PRK07492 521098001241 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 521098001242 tetramer interface [polypeptide binding]; other site 521098001243 active site 521098001244 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 521098001245 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 521098001246 ATP binding site [chemical binding]; other site 521098001247 active site 521098001248 substrate binding site [chemical binding]; other site 521098001249 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 521098001250 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 521098001251 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 521098001252 putative active site [active] 521098001253 catalytic triad [active] 521098001254 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 521098001255 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 521098001256 dimerization interface [polypeptide binding]; other site 521098001257 ATP binding site [chemical binding]; other site 521098001258 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 521098001259 dimerization interface [polypeptide binding]; other site 521098001260 ATP binding site [chemical binding]; other site 521098001261 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 521098001262 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 521098001263 active site 521098001264 tetramer interface [polypeptide binding]; other site 521098001265 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521098001266 active site 521098001267 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 521098001268 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 521098001269 dimerization interface [polypeptide binding]; other site 521098001270 putative ATP binding site [chemical binding]; other site 521098001271 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 521098001272 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 521098001273 purine monophosphate binding site [chemical binding]; other site 521098001274 dimer interface [polypeptide binding]; other site 521098001275 putative catalytic residues [active] 521098001276 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 521098001277 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 521098001278 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 521098001279 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 521098001280 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 521098001281 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 521098001282 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 521098001283 Triose-phosphate Transporter family; Region: TPT; pfam03151 521098001284 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 521098001285 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 521098001286 substrate binding site [chemical binding]; other site 521098001287 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 521098001288 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 521098001289 metal binding site [ion binding]; metal-binding site 521098001290 substrate binding pocket [chemical binding]; other site 521098001291 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 521098001292 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 521098001293 Walker A/P-loop; other site 521098001294 ATP binding site [chemical binding]; other site 521098001295 Q-loop/lid; other site 521098001296 ABC transporter signature motif; other site 521098001297 Walker B; other site 521098001298 D-loop; other site 521098001299 H-loop/switch region; other site 521098001300 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 521098001301 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 521098001302 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521098001303 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 521098001304 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 521098001305 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 521098001306 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 521098001307 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 521098001308 ligand binding site [chemical binding]; other site 521098001309 excinuclease ABC subunit B; Provisional; Region: PRK05298 521098001310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521098001311 ATP binding site [chemical binding]; other site 521098001312 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521098001313 nucleotide binding region [chemical binding]; other site 521098001314 ATP-binding site [chemical binding]; other site 521098001315 Ultra-violet resistance protein B; Region: UvrB; pfam12344 521098001316 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 521098001317 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 521098001318 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 521098001319 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 521098001320 HPr kinase/phosphorylase; Provisional; Region: PRK05428 521098001321 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 521098001322 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 521098001323 Hpr binding site; other site 521098001324 active site 521098001325 homohexamer subunit interaction site [polypeptide binding]; other site 521098001326 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 521098001327 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 521098001328 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 521098001329 active site 521098001330 HIGH motif; other site 521098001331 KMSK motif region; other site 521098001332 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 521098001333 tRNA binding surface [nucleotide binding]; other site 521098001334 anticodon binding site; other site 521098001335 TPR repeat; Region: TPR_11; pfam13414 521098001336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521098001337 binding surface 521098001338 TPR motif; other site 521098001339 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521098001340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521098001341 TPR motif; other site 521098001342 binding surface 521098001343 TPR repeat; Region: TPR_11; pfam13414 521098001344 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 521098001345 nudix motif; other site 521098001346 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 521098001347 AAA domain; Region: AAA_18; pfam13238 521098001348 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 521098001349 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 521098001350 phosphate binding site [ion binding]; other site 521098001351 putative substrate binding pocket [chemical binding]; other site 521098001352 dimer interface [polypeptide binding]; other site 521098001353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 521098001354 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 521098001355 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 521098001356 regulatory protein interface [polypeptide binding]; other site 521098001357 regulatory phosphorylation site [posttranslational modification]; other site 521098001358 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 521098001359 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 521098001360 minor groove reading motif; other site 521098001361 helix-hairpin-helix signature motif; other site 521098001362 substrate binding pocket [chemical binding]; other site 521098001363 active site 521098001364 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 521098001365 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 521098001366 DNA binding and oxoG recognition site [nucleotide binding] 521098001367 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 521098001368 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 521098001369 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 521098001370 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 521098001371 HIGH motif; other site 521098001372 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 521098001373 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 521098001374 active site 521098001375 KMSKS motif; other site 521098001376 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 521098001377 tRNA binding surface [nucleotide binding]; other site 521098001378 Transcriptional regulators [Transcription]; Region: FadR; COG2186 521098001379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521098001380 DNA-binding site [nucleotide binding]; DNA binding site 521098001381 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 521098001382 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 521098001383 NAD(P) binding site [chemical binding]; other site 521098001384 Domain of unknown function DUF20; Region: UPF0118; pfam01594 521098001385 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 521098001386 Protein of unknown function (DUF402); Region: DUF402; pfam04167 521098001387 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 521098001388 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 521098001389 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 521098001390 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521098001391 ATP binding site [chemical binding]; other site 521098001392 putative Mg++ binding site [ion binding]; other site 521098001393 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521098001394 nucleotide binding region [chemical binding]; other site 521098001395 ATP-binding site [chemical binding]; other site 521098001396 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 521098001397 RNase_H superfamily; Region: RNase_H_2; pfam13482 521098001398 active site 521098001399 substrate binding site [chemical binding]; other site 521098001400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 521098001401 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 521098001402 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 521098001403 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521098001404 active site 521098001405 metal binding site [ion binding]; metal-binding site 521098001406 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 521098001407 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 521098001408 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 521098001409 minor groove reading motif; other site 521098001410 helix-hairpin-helix signature motif; other site 521098001411 substrate binding pocket [chemical binding]; other site 521098001412 active site 521098001413 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 521098001414 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 521098001415 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 521098001416 Spore germination protein; Region: Spore_permease; cl17796 521098001417 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 521098001418 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 521098001419 active site 521098001420 NAD binding site [chemical binding]; other site 521098001421 metal binding site [ion binding]; metal-binding site 521098001422 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 521098001423 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 521098001424 tetrameric interface [polypeptide binding]; other site 521098001425 NAD binding site [chemical binding]; other site 521098001426 catalytic residues [active] 521098001427 benzoate transport; Region: 2A0115; TIGR00895 521098001428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098001429 putative substrate translocation pore; other site 521098001430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098001431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521098001432 PAS domain; Region: PAS_9; pfam13426 521098001433 putative active site [active] 521098001434 heme pocket [chemical binding]; other site 521098001435 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 521098001436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098001437 Walker A motif; other site 521098001438 ATP binding site [chemical binding]; other site 521098001439 Walker B motif; other site 521098001440 arginine finger; other site 521098001441 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 521098001442 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 521098001443 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 521098001444 active site 521098001445 acyl-activating enzyme (AAE) consensus motif; other site 521098001446 putative CoA binding site [chemical binding]; other site 521098001447 AMP binding site [chemical binding]; other site 521098001448 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 521098001449 RNA/DNA hybrid binding site [nucleotide binding]; other site 521098001450 active site 521098001451 epoxyqueuosine reductase; Region: TIGR00276 521098001452 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 521098001453 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 521098001454 protein binding surface [polypeptide binding]; other site 521098001455 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 521098001456 DNA binding site [nucleotide binding] 521098001457 active site 521098001458 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 521098001459 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 521098001460 tartrate dehydrogenase; Region: TTC; TIGR02089 521098001461 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 521098001462 Transcriptional regulator [Transcription]; Region: IclR; COG1414 521098001463 Bacterial transcriptional regulator; Region: IclR; pfam01614 521098001464 Putative amidase domain; Region: Amidase_6; pfam12671 521098001465 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 521098001466 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 521098001467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521098001468 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521098001469 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 521098001470 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 521098001471 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 521098001472 E3 interaction surface; other site 521098001473 lipoyl attachment site [posttranslational modification]; other site 521098001474 e3 binding domain; Region: E3_binding; pfam02817 521098001475 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 521098001476 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 521098001477 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 521098001478 alpha subunit interface [polypeptide binding]; other site 521098001479 TPP binding site [chemical binding]; other site 521098001480 heterodimer interface [polypeptide binding]; other site 521098001481 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521098001482 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 521098001483 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 521098001484 TPP-binding site [chemical binding]; other site 521098001485 heterodimer interface [polypeptide binding]; other site 521098001486 tetramer interface [polypeptide binding]; other site 521098001487 phosphorylation loop region [posttranslational modification] 521098001488 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 521098001489 Putative esterase; Region: Esterase; pfam00756 521098001490 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 521098001491 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 521098001492 substrate binding pocket [chemical binding]; other site 521098001493 catalytic triad [active] 521098001494 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 521098001495 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 521098001496 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 521098001497 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 521098001498 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 521098001499 catalytic residues [active] 521098001500 catalytic nucleophile [active] 521098001501 Presynaptic Site I dimer interface [polypeptide binding]; other site 521098001502 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 521098001503 Synaptic Flat tetramer interface [polypeptide binding]; other site 521098001504 Synaptic Site I dimer interface [polypeptide binding]; other site 521098001505 DNA binding site [nucleotide binding] 521098001506 Recombinase; Region: Recombinase; pfam07508 521098001507 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 521098001508 Domain of unknown function (DUF955); Region: DUF955; pfam06114 521098001509 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098001510 non-specific DNA binding site [nucleotide binding]; other site 521098001511 salt bridge; other site 521098001512 sequence-specific DNA binding site [nucleotide binding]; other site 521098001513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098001514 sequence-specific DNA binding site [nucleotide binding]; other site 521098001515 salt bridge; other site 521098001516 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521098001517 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098001518 non-specific DNA binding site [nucleotide binding]; other site 521098001519 salt bridge; other site 521098001520 sequence-specific DNA binding site [nucleotide binding]; other site 521098001521 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521098001522 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098001523 non-specific DNA binding site [nucleotide binding]; other site 521098001524 salt bridge; other site 521098001525 sequence-specific DNA binding site [nucleotide binding]; other site 521098001526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098001527 non-specific DNA binding site [nucleotide binding]; other site 521098001528 salt bridge; other site 521098001529 sequence-specific DNA binding site [nucleotide binding]; other site 521098001530 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521098001531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098001532 non-specific DNA binding site [nucleotide binding]; other site 521098001533 salt bridge; other site 521098001534 sequence-specific DNA binding site [nucleotide binding]; other site 521098001535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098001536 non-specific DNA binding site [nucleotide binding]; other site 521098001537 salt bridge; other site 521098001538 sequence-specific DNA binding site [nucleotide binding]; other site 521098001539 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 521098001540 Phage associated DNA primase [General function prediction only]; Region: COG3378 521098001541 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 521098001542 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521098001543 ATP binding site [chemical binding]; other site 521098001544 putative Mg++ binding site [ion binding]; other site 521098001545 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521098001546 nucleotide binding region [chemical binding]; other site 521098001547 ATP-binding site [chemical binding]; other site 521098001548 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 521098001549 DNA polymerase III subunit beta; Validated; Region: PRK05643 521098001550 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 521098001551 putative DNA binding surface [nucleotide binding]; other site 521098001552 dimer interface [polypeptide binding]; other site 521098001553 beta-clamp/translesion DNA polymerase binding surface; other site 521098001554 beta-clamp/clamp loader binding surface; other site 521098001555 Protein of unknown function (DUF669); Region: DUF669; pfam05037 521098001556 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 521098001557 AAA domain; Region: AAA_18; pfam13238 521098001558 AAA domain; Region: AAA_17; pfam13207 521098001559 exodeoxyribonuclease X; Provisional; Region: PRK07983 521098001560 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 521098001561 active site 521098001562 catalytic site [active] 521098001563 substrate binding site [chemical binding]; other site 521098001564 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 521098001565 Helix-turn-helix domain; Region: HTH_28; pfam13518 521098001566 Winged helix-turn helix; Region: HTH_29; pfam13551 521098001567 Homeodomain-like domain; Region: HTH_32; pfam13565 521098001568 Integrase core domain; Region: rve; pfam00665 521098001569 positive control sigma-like factor; Validated; Region: PRK06930 521098001570 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 521098001571 DNA binding residues [nucleotide binding] 521098001572 Transposase domain (DUF772); Region: DUF772; pfam05598 521098001573 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 521098001574 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 521098001575 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 521098001576 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 521098001577 transposase/IS protein; Provisional; Region: PRK09183 521098001578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098001579 Walker A motif; other site 521098001580 ATP binding site [chemical binding]; other site 521098001581 Walker B motif; other site 521098001582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 521098001583 MULE transposase domain; Region: MULE; pfam10551 521098001584 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 521098001585 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 521098001586 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 521098001587 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 521098001588 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 521098001589 D-pathway; other site 521098001590 Putative ubiquinol binding site [chemical binding]; other site 521098001591 Low-spin heme (heme b) binding site [chemical binding]; other site 521098001592 Putative water exit pathway; other site 521098001593 Binuclear center (heme o3/CuB) [ion binding]; other site 521098001594 K-pathway; other site 521098001595 Putative proton exit pathway; other site 521098001596 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 521098001597 Subunit I/III interface [polypeptide binding]; other site 521098001598 Subunit III/IV interface [polypeptide binding]; other site 521098001599 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 521098001600 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 521098001601 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521098001602 putative active site [active] 521098001603 heme pocket [chemical binding]; other site 521098001604 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521098001605 putative active site [active] 521098001606 heme pocket [chemical binding]; other site 521098001607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521098001608 dimer interface [polypeptide binding]; other site 521098001609 phosphorylation site [posttranslational modification] 521098001610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098001611 ATP binding site [chemical binding]; other site 521098001612 Mg2+ binding site [ion binding]; other site 521098001613 G-X-G motif; other site 521098001614 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 521098001615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098001616 active site 521098001617 phosphorylation site [posttranslational modification] 521098001618 intermolecular recognition site; other site 521098001619 dimerization interface [polypeptide binding]; other site 521098001620 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 521098001621 DNA binding residues [nucleotide binding] 521098001622 dimerization interface [polypeptide binding]; other site 521098001623 Transposase [DNA replication, recombination, and repair]; Region: COG5421 521098001624 Transposase [DNA replication, recombination, and repair]; Region: COG5421 521098001625 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 521098001626 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 521098001627 NAD(P) binding site [chemical binding]; other site 521098001628 LDH/MDH dimer interface [polypeptide binding]; other site 521098001629 substrate binding site [chemical binding]; other site 521098001630 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 521098001631 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 521098001632 Transposase domain (DUF772); Region: DUF772; pfam05598 521098001633 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 521098001634 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 521098001635 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 521098001636 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 521098001637 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 521098001638 metal binding site [ion binding]; metal-binding site 521098001639 active site 521098001640 I-site; other site 521098001641 PAS domain; Region: PAS_9; pfam13426 521098001642 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521098001643 putative active site [active] 521098001644 heme pocket [chemical binding]; other site 521098001645 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521098001646 Zn2+ binding site [ion binding]; other site 521098001647 Mg2+ binding site [ion binding]; other site 521098001648 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 521098001649 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 521098001650 dimer interface [polypeptide binding]; other site 521098001651 putative CheW interface [polypeptide binding]; other site 521098001652 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 521098001653 Ligand Binding Site [chemical binding]; other site 521098001654 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 521098001655 Uncharacterized conserved protein [Function unknown]; Region: COG1432 521098001656 LabA_like proteins; Region: LabA_like; cd06167 521098001657 putative metal binding site [ion binding]; other site 521098001658 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521098001659 dimerization interface [polypeptide binding]; other site 521098001660 putative DNA binding site [nucleotide binding]; other site 521098001661 putative Zn2+ binding site [ion binding]; other site 521098001662 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 521098001663 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521098001664 putative metal binding site [ion binding]; other site 521098001665 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 521098001666 arsenical pump membrane protein; Provisional; Region: PRK15445 521098001667 transmembrane helices; other site 521098001668 Low molecular weight phosphatase family; Region: LMWPc; cd00115 521098001669 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 521098001670 active site 521098001671 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 521098001672 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521098001673 Coenzyme A binding pocket [chemical binding]; other site 521098001674 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 521098001675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 521098001676 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 521098001677 Probable transposase; Region: OrfB_IS605; pfam01385 521098001678 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 521098001679 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 521098001680 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521098001681 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 521098001682 putative active site pocket [active] 521098001683 dimerization interface [polypeptide binding]; other site 521098001684 putative catalytic residue [active] 521098001685 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 521098001686 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 521098001687 DNA binding residues [nucleotide binding] 521098001688 dimerization interface [polypeptide binding]; other site 521098001689 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 521098001690 active site 521098001691 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 521098001692 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521098001693 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 521098001694 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 521098001695 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 521098001696 putative active site [active] 521098001697 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 521098001698 ParB-like nuclease domain; Region: ParB; smart00470 521098001699 BRO family, N-terminal domain; Region: Bro-N; smart01040 521098001700 Lantibiotic modifying enzyme [Defense mechanisms]; Region: LcnDR2; COG4403 521098001701 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 521098001702 AAA-like domain; Region: AAA_10; pfam12846 521098001703 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 521098001704 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 521098001705 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 521098001706 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521098001707 P-loop; other site 521098001708 Magnesium ion binding site [ion binding]; other site 521098001709 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 521098001710 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 521098001711 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 521098001712 Walker A motif; other site 521098001713 ATP binding site [chemical binding]; other site 521098001714 Walker B motif; other site 521098001715 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 521098001716 PRTRC system protein D; Region: PRTRC_D; TIGR03739 521098001717 Mg binding site [ion binding]; other site 521098001718 nucleotide binding site [chemical binding]; other site 521098001719 putative protofilament interface [polypeptide binding]; other site 521098001720 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 521098001721 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521098001722 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 521098001723 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 521098001724 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 521098001725 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521098001726 P-loop; other site 521098001727 Magnesium ion binding site [ion binding]; other site 521098001728 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 521098001729 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 521098001730 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 521098001731 Walker A motif; other site 521098001732 ATP binding site [chemical binding]; other site 521098001733 Walker B motif; other site 521098001734 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 521098001735 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521098001736 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 521098001737 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 521098001738 oligomeric interface; other site 521098001739 putative active site [active] 521098001740 homodimer interface [polypeptide binding]; other site 521098001741 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 521098001742 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 521098001743 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 521098001744 N-acetyl-D-glucosamine binding site [chemical binding]; other site 521098001745 catalytic residue [active] 521098001746 Domain of unknown function DUF87; Region: DUF87; pfam01935 521098001747 AAA-like domain; Region: AAA_10; pfam12846 521098001748 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 521098001749 Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3; Region: GINS_A; cl17012 521098001750 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 521098001751 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 521098001752 putative active site pocket [active] 521098001753 dimerization interface [polypeptide binding]; other site 521098001754 putative catalytic residue [active] 521098001755 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 521098001756 putative transporter; Provisional; Region: PRK11021 521098001757 Transcriptional regulator [Transcription]; Region: LysR; COG0583 521098001758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 521098001759 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 521098001760 dimerization interface [polypeptide binding]; other site 521098001761 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 521098001762 putative active site [active] 521098001763 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 521098001764 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 521098001765 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 521098001766 H+ Antiporter protein; Region: 2A0121; TIGR00900 521098001767 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 521098001768 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 521098001769 potential catalytic triad [active] 521098001770 conserved cys residue [active] 521098001771 TIGR02677 family protein; Region: TIGR02677 521098001772 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 521098001773 Protein of unknown function (DUF2398); Region: DUF2398; pfam09661 521098001774 TIGR02680 family protein; Region: TIGR02680 521098001775 P-loop containing region of AAA domain; Region: AAA_29; cl17516 521098001776 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 521098001777 TIGR02679 family protein; Region: TIGR02679 521098001778 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 521098001779 Predicted membrane protein [Function unknown]; Region: COG2860 521098001780 UPF0126 domain; Region: UPF0126; pfam03458 521098001781 UPF0126 domain; Region: UPF0126; pfam03458 521098001782 conserved hypothetical protein; Region: TIGR02328 521098001783 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 521098001784 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 521098001785 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521098001786 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521098001787 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 521098001788 ligand-binding site [chemical binding]; other site 521098001789 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 521098001790 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 521098001791 FMN binding site [chemical binding]; other site 521098001792 dimer interface [polypeptide binding]; other site 521098001793 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 521098001794 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 521098001795 hinge; other site 521098001796 active site 521098001797 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 521098001798 Protein export membrane protein; Region: SecD_SecF; cl14618 521098001799 IncA protein; Region: IncA; pfam04156 521098001800 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 521098001801 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 521098001802 Walker A/P-loop; other site 521098001803 ATP binding site [chemical binding]; other site 521098001804 Q-loop/lid; other site 521098001805 ABC transporter signature motif; other site 521098001806 Walker B; other site 521098001807 D-loop; other site 521098001808 H-loop/switch region; other site 521098001809 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 521098001810 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 521098001811 Walker A/P-loop; other site 521098001812 ATP binding site [chemical binding]; other site 521098001813 Q-loop/lid; other site 521098001814 ABC transporter signature motif; other site 521098001815 Walker B; other site 521098001816 D-loop; other site 521098001817 H-loop/switch region; other site 521098001818 Predicted transcriptional regulators [Transcription]; Region: COG1725 521098001819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521098001820 DNA-binding site [nucleotide binding]; DNA binding site 521098001821 ribonuclease Z; Region: RNase_Z; TIGR02651 521098001822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098001823 putative substrate translocation pore; other site 521098001824 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 521098001825 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 521098001826 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521098001827 dimerization interface [polypeptide binding]; other site 521098001828 putative DNA binding site [nucleotide binding]; other site 521098001829 putative Zn2+ binding site [ion binding]; other site 521098001830 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 521098001831 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 521098001832 TrkA-C domain; Region: TrkA_C; pfam02080 521098001833 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 521098001834 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 521098001835 Walker A/P-loop; other site 521098001836 ATP binding site [chemical binding]; other site 521098001837 Q-loop/lid; other site 521098001838 ABC transporter signature motif; other site 521098001839 Walker B; other site 521098001840 D-loop; other site 521098001841 H-loop/switch region; other site 521098001842 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 521098001843 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 521098001844 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 521098001845 Histidine kinase; Region: HisKA_3; pfam07730 521098001846 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 521098001847 ATP binding site [chemical binding]; other site 521098001848 Mg2+ binding site [ion binding]; other site 521098001849 G-X-G motif; other site 521098001850 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 521098001851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098001852 active site 521098001853 phosphorylation site [posttranslational modification] 521098001854 intermolecular recognition site; other site 521098001855 dimerization interface [polypeptide binding]; other site 521098001856 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 521098001857 DNA binding residues [nucleotide binding] 521098001858 dimerization interface [polypeptide binding]; other site 521098001859 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 521098001860 active site 521098001861 metal binding site [ion binding]; metal-binding site 521098001862 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 521098001863 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 521098001864 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 521098001865 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 521098001866 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 521098001867 D-pathway; other site 521098001868 Putative ubiquinol binding site [chemical binding]; other site 521098001869 Low-spin heme (heme b) binding site [chemical binding]; other site 521098001870 Putative water exit pathway; other site 521098001871 Binuclear center (heme o3/CuB) [ion binding]; other site 521098001872 K-pathway; other site 521098001873 Putative proton exit pathway; other site 521098001874 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 521098001875 Subunit I/III interface [polypeptide binding]; other site 521098001876 Subunit III/IV interface [polypeptide binding]; other site 521098001877 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 521098001878 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 521098001879 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 521098001880 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 521098001881 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 521098001882 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 521098001883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098001884 S-adenosylmethionine binding site [chemical binding]; other site 521098001885 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 521098001886 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521098001887 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521098001888 active site 521098001889 catalytic tetrad [active] 521098001890 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 521098001891 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 521098001892 active site 521098001893 NAD binding site [chemical binding]; other site 521098001894 metal binding site [ion binding]; metal-binding site 521098001895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521098001896 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 521098001897 NAD(P) binding site [chemical binding]; other site 521098001898 active site 521098001899 Protein of unknown function (DUF420); Region: DUF420; pfam04238 521098001900 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 521098001901 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 521098001902 CheB methylesterase; Region: CheB_methylest; pfam01339 521098001903 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 521098001904 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 521098001905 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 521098001906 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 521098001907 PAS domain; Region: PAS_10; pfam13596 521098001908 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 521098001909 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521098001910 putative active site [active] 521098001911 heme pocket [chemical binding]; other site 521098001912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521098001913 dimer interface [polypeptide binding]; other site 521098001914 phosphorylation site [posttranslational modification] 521098001915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098001916 ATP binding site [chemical binding]; other site 521098001917 Mg2+ binding site [ion binding]; other site 521098001918 G-X-G motif; other site 521098001919 B12 binding domain; Region: B12-binding_2; pfam02607 521098001920 B12 binding domain; Region: B12-binding; pfam02310 521098001921 B12 binding site [chemical binding]; other site 521098001922 classical (c) SDRs; Region: SDR_c; cd05233 521098001923 NAD(P) binding site [chemical binding]; other site 521098001924 active site 521098001925 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 521098001926 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 521098001927 putative active site [active] 521098001928 metal binding site [ion binding]; metal-binding site 521098001929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 521098001930 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 521098001931 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 521098001932 Part of AAA domain; Region: AAA_19; pfam13245 521098001933 Family description; Region: UvrD_C_2; pfam13538 521098001934 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 521098001935 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 521098001936 nucleotide binding pocket [chemical binding]; other site 521098001937 K-X-D-G motif; other site 521098001938 catalytic site [active] 521098001939 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 521098001940 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 521098001941 Helix-hairpin-helix motif; Region: HHH; pfam00633 521098001942 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 521098001943 Dimer interface [polypeptide binding]; other site 521098001944 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 521098001945 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 521098001946 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 521098001947 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 521098001948 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 521098001949 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 521098001950 GatB domain; Region: GatB_Yqey; smart00845 521098001951 TRAM domain; Region: TRAM; cl01282 521098001952 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 521098001953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098001954 S-adenosylmethionine binding site [chemical binding]; other site 521098001955 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521098001956 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 521098001957 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521098001958 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 521098001959 DNA binding site [nucleotide binding] 521098001960 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521098001961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521098001962 Walker A/P-loop; other site 521098001963 ATP binding site [chemical binding]; other site 521098001964 Q-loop/lid; other site 521098001965 ABC transporter signature motif; other site 521098001966 Walker B; other site 521098001967 D-loop; other site 521098001968 H-loop/switch region; other site 521098001969 Membrane transport protein; Region: Mem_trans; cl09117 521098001970 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 521098001971 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 521098001972 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 521098001973 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 521098001974 dimerization interface [polypeptide binding]; other site 521098001975 DPS ferroxidase diiron center [ion binding]; other site 521098001976 ion pore; other site 521098001977 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 521098001978 N- and C-terminal domain interface [polypeptide binding]; other site 521098001979 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 521098001980 active site 521098001981 putative catalytic site [active] 521098001982 metal binding site [ion binding]; metal-binding site 521098001983 ATP binding site [chemical binding]; other site 521098001984 carbohydrate binding site [chemical binding]; other site 521098001985 short chain dehydrogenase; Validated; Region: PRK08324 521098001986 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 521098001987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521098001988 NAD(P) binding site [chemical binding]; other site 521098001989 active site 521098001990 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 521098001991 Anabaena sensory rhodopsin transducer; Region: ASRT; cl01751 521098001992 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 521098001993 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 521098001994 Walker A/P-loop; other site 521098001995 ATP binding site [chemical binding]; other site 521098001996 Q-loop/lid; other site 521098001997 ABC transporter signature motif; other site 521098001998 Walker B; other site 521098001999 D-loop; other site 521098002000 H-loop/switch region; other site 521098002001 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 521098002002 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 521098002003 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 521098002004 TM-ABC transporter signature motif; other site 521098002005 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 521098002006 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 521098002007 TM-ABC transporter signature motif; other site 521098002008 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 521098002009 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 521098002010 ligand binding site [chemical binding]; other site 521098002011 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 521098002012 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 521098002013 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 521098002014 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 521098002015 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 521098002016 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 521098002017 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 521098002018 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 521098002019 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 521098002020 Cysteine-rich domain; Region: CCG; pfam02754 521098002021 Cysteine-rich domain; Region: CCG; pfam02754 521098002022 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 521098002023 Predicted membrane protein [Function unknown]; Region: COG2323 521098002024 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 521098002025 SpoVA protein; Region: SpoVA; cl04298 521098002026 stage V sporulation protein AD; Provisional; Region: PRK12404 521098002027 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 521098002028 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 521098002029 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 521098002030 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 521098002031 catalytic triad [active] 521098002032 catalytic triad [active] 521098002033 oxyanion hole [active] 521098002034 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 521098002035 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 521098002036 active site 521098002037 catalytic triad [active] 521098002038 oxyanion hole [active] 521098002039 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 521098002040 active site 521098002041 catalytic triad [active] 521098002042 oxyanion hole [active] 521098002043 Acyltransferase family; Region: Acyl_transf_3; pfam01757 521098002044 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 521098002045 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 521098002046 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521098002047 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 521098002048 acyl-activating enzyme (AAE) consensus motif; other site 521098002049 putative AMP binding site [chemical binding]; other site 521098002050 putative active site [active] 521098002051 putative CoA binding site [chemical binding]; other site 521098002052 SurA N-terminal domain; Region: SurA_N_3; cl07813 521098002053 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 521098002054 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 521098002055 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 521098002056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098002057 putative substrate translocation pore; other site 521098002058 Uncharacterized conserved protein [Function unknown]; Region: COG2155 521098002059 diaminopimelate decarboxylase; Region: lysA; TIGR01048 521098002060 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 521098002061 active site 521098002062 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521098002063 substrate binding site [chemical binding]; other site 521098002064 catalytic residues [active] 521098002065 dimer interface [polypeptide binding]; other site 521098002066 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 521098002067 Fumarase C-terminus; Region: Fumerase_C; pfam05683 521098002068 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521098002069 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 521098002070 dimer interface [polypeptide binding]; other site 521098002071 manganese transport protein MntH; Reviewed; Region: PRK00701 521098002072 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 521098002073 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 521098002074 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 521098002075 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 521098002076 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 521098002077 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 521098002078 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 521098002079 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 521098002080 active site 521098002081 catalytic motif [active] 521098002082 Zn binding site [ion binding]; other site 521098002083 oligoendopeptidase F; Region: pepF; TIGR00181 521098002084 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 521098002085 active site 521098002086 Zn binding site [ion binding]; other site 521098002087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521098002088 dimer interface [polypeptide binding]; other site 521098002089 phosphorylation site [posttranslational modification] 521098002090 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 521098002091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098002092 ATP binding site [chemical binding]; other site 521098002093 Mg2+ binding site [ion binding]; other site 521098002094 G-X-G motif; other site 521098002095 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 521098002096 Phosphoglycerate kinase; Region: PGK; pfam00162 521098002097 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 521098002098 substrate binding site [chemical binding]; other site 521098002099 hinge regions; other site 521098002100 ADP binding site [chemical binding]; other site 521098002101 catalytic site [active] 521098002102 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 521098002103 triosephosphate isomerase; Provisional; Region: PRK14565 521098002104 substrate binding site [chemical binding]; other site 521098002105 dimer interface [polypeptide binding]; other site 521098002106 catalytic triad [active] 521098002107 phosphoglyceromutase; Provisional; Region: PRK05434 521098002108 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 521098002109 enolase; Provisional; Region: eno; PRK00077 521098002110 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 521098002111 dimer interface [polypeptide binding]; other site 521098002112 metal binding site [ion binding]; metal-binding site 521098002113 substrate binding pocket [chemical binding]; other site 521098002114 cyanate transporter; Region: CynX; TIGR00896 521098002115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098002116 putative substrate translocation pore; other site 521098002117 ribonuclease R; Region: RNase_R; TIGR02063 521098002118 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 521098002119 RNB domain; Region: RNB; pfam00773 521098002120 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 521098002121 RNA binding site [nucleotide binding]; other site 521098002122 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 521098002123 SmpB-tmRNA interface; other site 521098002124 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 521098002125 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 521098002126 NAD(P) binding site [chemical binding]; other site 521098002127 catalytic residues [active] 521098002128 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 521098002129 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 521098002130 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 521098002131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 521098002132 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 521098002133 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521098002134 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521098002135 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 521098002136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098002137 S-adenosylmethionine binding site [chemical binding]; other site 521098002138 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 521098002139 peptidase domain interface [polypeptide binding]; other site 521098002140 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 521098002141 active site 521098002142 catalytic triad [active] 521098002143 calcium binding site [ion binding]; other site 521098002144 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 521098002145 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 521098002146 THF binding site; other site 521098002147 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 521098002148 substrate binding site [chemical binding]; other site 521098002149 THF binding site; other site 521098002150 zinc-binding site [ion binding]; other site 521098002151 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 521098002152 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 521098002153 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 521098002154 Amino acid permease; Region: AA_permease_2; pfam13520 521098002155 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 521098002156 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 521098002157 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 521098002158 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 521098002159 urea carboxylase; Region: urea_carbox; TIGR02712 521098002160 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 521098002161 ATP-grasp domain; Region: ATP-grasp_4; cl17255 521098002162 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 521098002163 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 521098002164 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 521098002165 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 521098002166 carboxyltransferase (CT) interaction site; other site 521098002167 biotinylation site [posttranslational modification]; other site 521098002168 allophanate hydrolase; Provisional; Region: PRK08186 521098002169 Amidase; Region: Amidase; cl11426 521098002170 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 521098002171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098002172 dimer interface [polypeptide binding]; other site 521098002173 conserved gate region; other site 521098002174 putative PBP binding loops; other site 521098002175 ABC-ATPase subunit interface; other site 521098002176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098002177 dimer interface [polypeptide binding]; other site 521098002178 conserved gate region; other site 521098002179 putative PBP binding loops; other site 521098002180 ABC-ATPase subunit interface; other site 521098002181 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 521098002182 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 521098002183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098002184 H+ Antiporter protein; Region: 2A0121; TIGR00900 521098002185 putative substrate translocation pore; other site 521098002186 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 521098002187 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 521098002188 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 521098002189 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 521098002190 Catalytic site [active] 521098002191 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521098002192 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521098002193 active site 521098002194 catalytic tetrad [active] 521098002195 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 521098002196 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 521098002197 G1 box; other site 521098002198 putative GEF interaction site [polypeptide binding]; other site 521098002199 GTP/Mg2+ binding site [chemical binding]; other site 521098002200 Switch I region; other site 521098002201 G2 box; other site 521098002202 G3 box; other site 521098002203 Switch II region; other site 521098002204 G4 box; other site 521098002205 G5 box; other site 521098002206 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 521098002207 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 521098002208 active site 521098002209 Zn binding site [ion binding]; other site 521098002210 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 521098002211 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521098002212 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 521098002213 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 521098002214 extended (e) SDRs; Region: SDR_e; cd08946 521098002215 NAD(P) binding site [chemical binding]; other site 521098002216 active site 521098002217 substrate binding site [chemical binding]; other site 521098002218 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 521098002219 Melibiase; Region: Melibiase; pfam02065 521098002220 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521098002221 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521098002222 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 521098002223 nucleotide binding site [chemical binding]; other site 521098002224 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521098002225 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 521098002226 dimer interface [polypeptide binding]; other site 521098002227 substrate binding site [chemical binding]; other site 521098002228 metal binding site [ion binding]; metal-binding site 521098002229 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 521098002230 Putative glucoamylase; Region: Glycoamylase; pfam10091 521098002231 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 521098002232 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 521098002233 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 521098002234 benzoate transport; Region: 2A0115; TIGR00895 521098002235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098002236 putative substrate translocation pore; other site 521098002237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098002238 putative substrate translocation pore; other site 521098002239 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521098002240 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521098002241 DNA binding site [nucleotide binding] 521098002242 domain linker motif; other site 521098002243 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 521098002244 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 521098002245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098002246 dimer interface [polypeptide binding]; other site 521098002247 conserved gate region; other site 521098002248 putative PBP binding loops; other site 521098002249 ABC-ATPase subunit interface; other site 521098002250 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 521098002251 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 521098002252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098002253 dimer interface [polypeptide binding]; other site 521098002254 conserved gate region; other site 521098002255 putative PBP binding loops; other site 521098002256 ABC-ATPase subunit interface; other site 521098002257 alpha-galactosidase; Provisional; Region: PRK15076 521098002258 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 521098002259 NAD binding site [chemical binding]; other site 521098002260 sugar binding site [chemical binding]; other site 521098002261 divalent metal binding site [ion binding]; other site 521098002262 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 521098002263 dimer interface [polypeptide binding]; other site 521098002264 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 521098002265 dimer interface [polypeptide binding]; other site 521098002266 Citrate synthase; Region: Citrate_synt; pfam00285 521098002267 active site 521098002268 coenzyme A binding site [chemical binding]; other site 521098002269 citrylCoA binding site [chemical binding]; other site 521098002270 oxalacetate/citrate binding site [chemical binding]; other site 521098002271 catalytic triad [active] 521098002272 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 521098002273 2-methylcitrate dehydratase; Region: prpD; TIGR02330 521098002274 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 521098002275 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 521098002276 tetramer interface [polypeptide binding]; other site 521098002277 active site 521098002278 Mg2+/Mn2+ binding site [ion binding]; other site 521098002279 threonine dehydratase; Provisional; Region: PRK08198 521098002280 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 521098002281 tetramer interface [polypeptide binding]; other site 521098002282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098002283 catalytic residue [active] 521098002284 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 521098002285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098002286 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 521098002287 Walker A motif; other site 521098002288 ATP binding site [chemical binding]; other site 521098002289 Walker B motif; other site 521098002290 arginine finger; other site 521098002291 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 521098002292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098002293 Walker A motif; other site 521098002294 ATP binding site [chemical binding]; other site 521098002295 Walker B motif; other site 521098002296 arginine finger; other site 521098002297 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 521098002298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 521098002299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 521098002300 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 521098002301 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 521098002302 Phenylacetic acid degradation B; Region: PaaB; pfam06243 521098002303 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 521098002304 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 521098002305 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 521098002306 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521098002307 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 521098002308 acyl-activating enzyme (AAE) consensus motif; other site 521098002309 AMP binding site [chemical binding]; other site 521098002310 active site 521098002311 CoA binding site [chemical binding]; other site 521098002312 conserved hypothetical protein; Region: TIGR02118 521098002313 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 521098002314 active site 2 [active] 521098002315 active site 1 [active] 521098002316 succinic semialdehyde dehydrogenase; Region: PLN02278 521098002317 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 521098002318 tetramerization interface [polypeptide binding]; other site 521098002319 NAD(P) binding site [chemical binding]; other site 521098002320 catalytic residues [active] 521098002321 enoyl-CoA hydratase; Provisional; Region: PRK08140 521098002322 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 521098002323 substrate binding site [chemical binding]; other site 521098002324 oxyanion hole (OAH) forming residues; other site 521098002325 trimer interface [polypeptide binding]; other site 521098002326 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 521098002327 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 521098002328 dimer interface [polypeptide binding]; other site 521098002329 active site 521098002330 RmuC family; Region: RmuC; pfam02646 521098002331 YjzC-like protein; Region: YjzC; pfam14168 521098002332 LrgB-like family; Region: LrgB; pfam04172 521098002333 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 521098002334 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 521098002335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 521098002336 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 521098002337 dimerization interface [polypeptide binding]; other site 521098002338 substrate binding pocket [chemical binding]; other site 521098002339 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 521098002340 CoenzymeA binding site [chemical binding]; other site 521098002341 subunit interaction site [polypeptide binding]; other site 521098002342 PHB binding site; other site 521098002343 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 521098002344 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 521098002345 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521098002346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098002347 homodimer interface [polypeptide binding]; other site 521098002348 catalytic residue [active] 521098002349 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 521098002350 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 521098002351 TPP-binding site [chemical binding]; other site 521098002352 tetramer interface [polypeptide binding]; other site 521098002353 heterodimer interface [polypeptide binding]; other site 521098002354 phosphorylation loop region [posttranslational modification] 521098002355 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 521098002356 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 521098002357 alpha subunit interface [polypeptide binding]; other site 521098002358 TPP binding site [chemical binding]; other site 521098002359 heterodimer interface [polypeptide binding]; other site 521098002360 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521098002361 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 521098002362 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 521098002363 E3 interaction surface; other site 521098002364 lipoyl attachment site [posttranslational modification]; other site 521098002365 e3 binding domain; Region: E3_binding; pfam02817 521098002366 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 521098002367 enoyl-CoA hydratase; Provisional; Region: PRK08138 521098002368 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 521098002369 substrate binding site [chemical binding]; other site 521098002370 oxyanion hole (OAH) forming residues; other site 521098002371 trimer interface [polypeptide binding]; other site 521098002372 Predicted permeases [General function prediction only]; Region: RarD; COG2962 521098002373 enterobactin exporter EntS; Provisional; Region: PRK10489 521098002374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098002375 putative substrate translocation pore; other site 521098002376 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 521098002377 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 521098002378 catalytic Zn binding site [ion binding]; other site 521098002379 NAD(P) binding site [chemical binding]; other site 521098002380 structural Zn binding site [ion binding]; other site 521098002381 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521098002382 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 521098002383 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521098002384 Walker A/P-loop; other site 521098002385 ATP binding site [chemical binding]; other site 521098002386 Q-loop/lid; other site 521098002387 ABC transporter signature motif; other site 521098002388 Walker B; other site 521098002389 D-loop; other site 521098002390 H-loop/switch region; other site 521098002391 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521098002392 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 521098002393 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521098002394 Walker A/P-loop; other site 521098002395 ATP binding site [chemical binding]; other site 521098002396 Q-loop/lid; other site 521098002397 ABC transporter signature motif; other site 521098002398 Walker B; other site 521098002399 D-loop; other site 521098002400 H-loop/switch region; other site 521098002401 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 521098002402 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 521098002403 putative NADP binding site [chemical binding]; other site 521098002404 putative dimer interface [polypeptide binding]; other site 521098002405 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 521098002406 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521098002407 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521098002408 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521098002409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521098002410 Walker A/P-loop; other site 521098002411 ATP binding site [chemical binding]; other site 521098002412 Q-loop/lid; other site 521098002413 ABC transporter signature motif; other site 521098002414 Walker B; other site 521098002415 D-loop; other site 521098002416 H-loop/switch region; other site 521098002417 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521098002418 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521098002419 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 521098002420 Walker A/P-loop; other site 521098002421 ATP binding site [chemical binding]; other site 521098002422 Q-loop/lid; other site 521098002423 ABC transporter signature motif; other site 521098002424 Walker B; other site 521098002425 D-loop; other site 521098002426 H-loop/switch region; other site 521098002427 Uncharacterized class III extradiol dioxygenases; Region: ED_3B_like; cd07952 521098002428 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 521098002429 putative active site [active] 521098002430 putative metal binding site [ion binding]; other site 521098002431 Uncharacterized conserved protein [Function unknown]; Region: COG5609 521098002432 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 521098002433 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 521098002434 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 521098002435 catalytic loop [active] 521098002436 iron binding site [ion binding]; other site 521098002437 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 521098002438 4Fe-4S binding domain; Region: Fer4; pfam00037 521098002439 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 521098002440 [4Fe-4S] binding site [ion binding]; other site 521098002441 molybdopterin cofactor binding site; other site 521098002442 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 521098002443 molybdopterin cofactor binding site; other site 521098002444 Uncharacterized conserved protein [Function unknown]; Region: COG2427 521098002445 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 521098002446 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521098002447 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 521098002448 active site residue [active] 521098002449 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521098002450 active site 521098002451 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521098002452 catalytic tetrad [active] 521098002453 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 521098002454 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 521098002455 active site 521098002456 catalytic residues [active] 521098002457 metal binding site [ion binding]; metal-binding site 521098002458 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 521098002459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098002460 drug efflux system protein MdtG; Provisional; Region: PRK09874 521098002461 putative substrate translocation pore; other site 521098002462 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 521098002463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521098002464 active site 521098002465 motif I; other site 521098002466 motif II; other site 521098002467 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521098002468 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 521098002469 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 521098002470 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 521098002471 active site 521098002472 Zn binding site [ion binding]; other site 521098002473 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 521098002474 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 521098002475 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521098002476 catalytic residues [active] 521098002477 methionine sulfoxide reductase A; Provisional; Region: PRK14054 521098002478 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 521098002479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521098002480 Walker A/P-loop; other site 521098002481 ATP binding site [chemical binding]; other site 521098002482 Q-loop/lid; other site 521098002483 ABC transporter signature motif; other site 521098002484 Walker B; other site 521098002485 D-loop; other site 521098002486 H-loop/switch region; other site 521098002487 Uncharacterized conserved protein [Function unknown]; Region: COG2353 521098002488 Predicted transcriptional regulators [Transcription]; Region: COG1733 521098002489 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521098002490 dimerization interface [polypeptide binding]; other site 521098002491 putative DNA binding site [nucleotide binding]; other site 521098002492 putative Zn2+ binding site [ion binding]; other site 521098002493 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521098002494 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 521098002495 active site 521098002496 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 521098002497 ATP-sulfurylase; Region: ATPS; cd00517 521098002498 active site 521098002499 HXXH motif; other site 521098002500 flexible loop; other site 521098002501 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 521098002502 MarR family; Region: MarR; pfam01047 521098002503 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 521098002504 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 521098002505 active site 521098002506 HIGH motif; other site 521098002507 nucleotide binding site [chemical binding]; other site 521098002508 active site 521098002509 KMSKS motif; other site 521098002510 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 521098002511 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 521098002512 NAD(P) binding site [chemical binding]; other site 521098002513 catalytic residues [active] 521098002514 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521098002515 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521098002516 active site 521098002517 catalytic tetrad [active] 521098002518 Putative methyltransferase; Region: Methyltransf_4; cl17290 521098002519 Isochorismatase family; Region: Isochorismatase; pfam00857 521098002520 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 521098002521 catalytic triad [active] 521098002522 conserved cis-peptide bond; other site 521098002523 photosystem II stability/assembly factor; Provisional; Region: PLN00033 521098002524 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 521098002525 active site 521098002526 oxyanion hole [active] 521098002527 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 521098002528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098002529 putative substrate translocation pore; other site 521098002530 Part of AAA domain; Region: AAA_19; pfam13245 521098002531 Family description; Region: UvrD_C_2; pfam13538 521098002532 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 521098002533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521098002534 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521098002535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098002536 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521098002537 putative substrate translocation pore; other site 521098002538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098002539 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 521098002540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521098002541 Coenzyme A binding pocket [chemical binding]; other site 521098002542 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 521098002543 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 521098002544 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 521098002545 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 521098002546 Low molecular weight phosphatase family; Region: LMWPc; cd00115 521098002547 active site 521098002548 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 521098002549 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521098002550 catalytic residues [active] 521098002551 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 521098002552 CoA binding domain; Region: CoA_binding_2; pfam13380 521098002553 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 521098002554 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 521098002555 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 521098002556 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 521098002557 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521098002558 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521098002559 active site 521098002560 phosphorylation site [posttranslational modification] 521098002561 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 521098002562 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 521098002563 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 521098002564 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 521098002565 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 521098002566 putative substrate binding site [chemical binding]; other site 521098002567 putative ATP binding site [chemical binding]; other site 521098002568 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 521098002569 active site 521098002570 P-loop; other site 521098002571 phosphorylation site [posttranslational modification] 521098002572 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 521098002573 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 521098002574 amidase; Provisional; Region: PRK06828 521098002575 Amidase; Region: Amidase; cl11426 521098002576 Protein of unknown function (DUF423); Region: DUF423; pfam04241 521098002577 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 521098002578 EamA-like transporter family; Region: EamA; pfam00892 521098002579 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 521098002580 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521098002581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 521098002582 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 521098002583 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 521098002584 SWIM zinc finger; Region: SWIM; pfam04434 521098002585 cystathionine gamma-synthase; Reviewed; Region: PRK08247 521098002586 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 521098002587 homodimer interface [polypeptide binding]; other site 521098002588 substrate-cofactor binding pocket; other site 521098002589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098002590 catalytic residue [active] 521098002591 Methyltransferase domain; Region: Methyltransf_31; pfam13847 521098002592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098002593 S-adenosylmethionine binding site [chemical binding]; other site 521098002594 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 521098002595 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 521098002596 TPP-binding site [chemical binding]; other site 521098002597 heterodimer interface [polypeptide binding]; other site 521098002598 tetramer interface [polypeptide binding]; other site 521098002599 phosphorylation loop region [posttranslational modification] 521098002600 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 521098002601 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 521098002602 alpha subunit interface [polypeptide binding]; other site 521098002603 TPP binding site [chemical binding]; other site 521098002604 heterodimer interface [polypeptide binding]; other site 521098002605 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521098002606 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 521098002607 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521098002608 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 521098002609 acyl-activating enzyme (AAE) consensus motif; other site 521098002610 putative AMP binding site [chemical binding]; other site 521098002611 putative active site [active] 521098002612 putative CoA binding site [chemical binding]; other site 521098002613 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 521098002614 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 521098002615 putative active site [active] 521098002616 putative substrate binding site [chemical binding]; other site 521098002617 putative FMN binding site [chemical binding]; other site 521098002618 putative catalytic residues [active] 521098002619 Maf-like protein; Region: Maf; pfam02545 521098002620 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 521098002621 active site 521098002622 dimer interface [polypeptide binding]; other site 521098002623 HI0933-like protein; Region: HI0933_like; pfam03486 521098002624 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 521098002625 EamA-like transporter family; Region: EamA; pfam00892 521098002626 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 521098002627 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 521098002628 dimer interface [polypeptide binding]; other site 521098002629 active site 521098002630 metal binding site [ion binding]; metal-binding site 521098002631 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521098002632 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521098002633 DNA binding site [nucleotide binding] 521098002634 domain linker motif; other site 521098002635 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 521098002636 dimerization interface [polypeptide binding]; other site 521098002637 ligand binding site [chemical binding]; other site 521098002638 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 521098002639 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 521098002640 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 521098002641 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 521098002642 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 521098002643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098002644 dimer interface [polypeptide binding]; other site 521098002645 conserved gate region; other site 521098002646 putative PBP binding loops; other site 521098002647 ABC-ATPase subunit interface; other site 521098002648 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 521098002649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098002650 dimer interface [polypeptide binding]; other site 521098002651 conserved gate region; other site 521098002652 putative PBP binding loops; other site 521098002653 ABC-ATPase subunit interface; other site 521098002654 aconitate hydratase; Validated; Region: PRK09277 521098002655 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 521098002656 substrate binding site [chemical binding]; other site 521098002657 ligand binding site [chemical binding]; other site 521098002658 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 521098002659 substrate binding site [chemical binding]; other site 521098002660 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 521098002661 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 521098002662 Mg++ binding site [ion binding]; other site 521098002663 putative catalytic motif [active] 521098002664 substrate binding site [chemical binding]; other site 521098002665 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 521098002666 UbiA prenyltransferase family; Region: UbiA; pfam01040 521098002667 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 521098002668 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 521098002669 putative NAD(P) binding site [chemical binding]; other site 521098002670 catalytic Zn binding site [ion binding]; other site 521098002671 structural Zn binding site [ion binding]; other site 521098002672 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 521098002673 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 521098002674 NAD(P) binding site [chemical binding]; other site 521098002675 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 521098002676 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 521098002677 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 521098002678 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521098002679 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 521098002680 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 521098002681 motif 1; other site 521098002682 dimer interface [polypeptide binding]; other site 521098002683 active site 521098002684 motif 2; other site 521098002685 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 521098002686 active site 521098002687 motif 3; other site 521098002688 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 521098002689 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 521098002690 histidinol dehydrogenase; Region: hisD; TIGR00069 521098002691 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 521098002692 NAD binding site [chemical binding]; other site 521098002693 dimerization interface [polypeptide binding]; other site 521098002694 product binding site; other site 521098002695 substrate binding site [chemical binding]; other site 521098002696 zinc binding site [ion binding]; other site 521098002697 catalytic residues [active] 521098002698 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 521098002699 putative active site pocket [active] 521098002700 4-fold oligomerization interface [polypeptide binding]; other site 521098002701 metal binding residues [ion binding]; metal-binding site 521098002702 3-fold/trimer interface [polypeptide binding]; other site 521098002703 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 521098002704 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 521098002705 putative active site [active] 521098002706 oxyanion strand; other site 521098002707 catalytic triad [active] 521098002708 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 521098002709 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 521098002710 catalytic residues [active] 521098002711 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 521098002712 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 521098002713 substrate binding site [chemical binding]; other site 521098002714 glutamase interaction surface [polypeptide binding]; other site 521098002715 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 521098002716 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 521098002717 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 521098002718 metal binding site [ion binding]; metal-binding site 521098002719 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 521098002720 EamA-like transporter family; Region: EamA; pfam00892 521098002721 EamA-like transporter family; Region: EamA; pfam00892 521098002722 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 521098002723 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 521098002724 putative NAD(P) binding site [chemical binding]; other site 521098002725 dimer interface [polypeptide binding]; other site 521098002726 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 521098002727 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 521098002728 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 521098002729 catalytic motif [active] 521098002730 Zn binding site [ion binding]; other site 521098002731 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 521098002732 RibD C-terminal domain; Region: RibD_C; cl17279 521098002733 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 521098002734 Lumazine binding domain; Region: Lum_binding; pfam00677 521098002735 Lumazine binding domain; Region: Lum_binding; pfam00677 521098002736 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 521098002737 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 521098002738 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 521098002739 dimerization interface [polypeptide binding]; other site 521098002740 active site 521098002741 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 521098002742 homopentamer interface [polypeptide binding]; other site 521098002743 active site 521098002744 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 521098002745 DNA-binding site [nucleotide binding]; DNA binding site 521098002746 RNA-binding motif; other site 521098002747 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 521098002748 PIN domain; Region: PIN_3; cl17397 521098002749 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 521098002750 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 521098002751 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 521098002752 Walker A/P-loop; other site 521098002753 ATP binding site [chemical binding]; other site 521098002754 Q-loop/lid; other site 521098002755 ABC transporter signature motif; other site 521098002756 Walker B; other site 521098002757 D-loop; other site 521098002758 H-loop/switch region; other site 521098002759 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 521098002760 Walker A/P-loop; other site 521098002761 ATP binding site [chemical binding]; other site 521098002762 Q-loop/lid; other site 521098002763 ABC transporter signature motif; other site 521098002764 Walker B; other site 521098002765 D-loop; other site 521098002766 H-loop/switch region; other site 521098002767 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 521098002768 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 521098002769 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 521098002770 TPP-binding site [chemical binding]; other site 521098002771 dimer interface [polypeptide binding]; other site 521098002772 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 521098002773 PYR/PP interface [polypeptide binding]; other site 521098002774 dimer interface [polypeptide binding]; other site 521098002775 TPP binding site [chemical binding]; other site 521098002776 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521098002777 Transcriptional regulator [Transcription]; Region: LysR; COG0583 521098002778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 521098002779 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 521098002780 dimerization interface [polypeptide binding]; other site 521098002781 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 521098002782 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 521098002783 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 521098002784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521098002785 NAD(P) binding site [chemical binding]; other site 521098002786 active site 521098002787 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 521098002788 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 521098002789 active site residue [active] 521098002790 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 521098002791 active site residue [active] 521098002792 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 521098002793 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 521098002794 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 521098002795 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 521098002796 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 521098002797 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 521098002798 active site 521098002799 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 521098002800 conserved cys residue [active] 521098002801 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 521098002802 Part of AAA domain; Region: AAA_19; pfam13245 521098002803 Family description; Region: UvrD_C_2; pfam13538 521098002804 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 521098002805 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 521098002806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521098002807 Coenzyme A binding pocket [chemical binding]; other site 521098002808 NifU-like domain; Region: NifU; cl00484 521098002809 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521098002810 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 521098002811 active site 521098002812 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 521098002813 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 521098002814 homooctamer interface [polypeptide binding]; other site 521098002815 active site 521098002816 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 521098002817 Rogdi leucine zipper containing protein; Region: Rogdi_lz; pfam10259 521098002818 potential frameshift: common BLAST hit: gi|212639198|ref|YP_002315718.1| Predicted GTPase 521098002819 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 521098002820 G1 box; other site 521098002821 GTP/Mg2+ binding site [chemical binding]; other site 521098002822 G2 box; other site 521098002823 Switch I region; other site 521098002824 G3 box; other site 521098002825 Switch II region; other site 521098002826 G4 box; other site 521098002827 G5 box; other site 521098002828 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 521098002829 G1 box; other site 521098002830 GTP/Mg2+ binding site [chemical binding]; other site 521098002831 G2 box; other site 521098002832 Switch I region; other site 521098002833 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 521098002834 G3 box; other site 521098002835 Switch II region; other site 521098002836 G4 box; other site 521098002837 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521098002838 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521098002839 protein binding site [polypeptide binding]; other site 521098002840 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 521098002841 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 521098002842 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 521098002843 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 521098002844 catalytic residues [active] 521098002845 catalytic nucleophile [active] 521098002846 Recombinase; Region: Recombinase; pfam07508 521098002847 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 521098002848 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 521098002849 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 521098002850 homodecamer interface [polypeptide binding]; other site 521098002851 GTP cyclohydrolase I; Provisional; Region: PLN03044 521098002852 active site 521098002853 putative catalytic site residues [active] 521098002854 zinc binding site [ion binding]; other site 521098002855 GTP-CH-I/GFRP interaction surface; other site 521098002856 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 521098002857 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 521098002858 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 521098002859 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 521098002860 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 521098002861 NAD binding site [chemical binding]; other site 521098002862 homotetramer interface [polypeptide binding]; other site 521098002863 homodimer interface [polypeptide binding]; other site 521098002864 substrate binding site [chemical binding]; other site 521098002865 active site 521098002866 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 521098002867 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 521098002868 quinone interaction residues [chemical binding]; other site 521098002869 active site 521098002870 catalytic residues [active] 521098002871 FMN binding site [chemical binding]; other site 521098002872 substrate binding site [chemical binding]; other site 521098002873 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 521098002874 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521098002875 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521098002876 DNA binding residues [nucleotide binding] 521098002877 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 521098002878 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 521098002879 hexamer interface [polypeptide binding]; other site 521098002880 ligand binding site [chemical binding]; other site 521098002881 putative active site [active] 521098002882 NAD(P) binding site [chemical binding]; other site 521098002883 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 521098002884 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 521098002885 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 521098002886 Walker A/P-loop; other site 521098002887 ATP binding site [chemical binding]; other site 521098002888 Q-loop/lid; other site 521098002889 ABC transporter signature motif; other site 521098002890 Walker B; other site 521098002891 D-loop; other site 521098002892 H-loop/switch region; other site 521098002893 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 521098002894 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 521098002895 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 521098002896 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 521098002897 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521098002898 catalytic residue [active] 521098002899 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 521098002900 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 521098002901 trimerization site [polypeptide binding]; other site 521098002902 active site 521098002903 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 521098002904 FeS assembly protein SufB; Region: sufB; TIGR01980 521098002905 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 521098002906 [2Fe-2S] cluster binding site [ion binding]; other site 521098002907 Rrf2 family protein; Region: rrf2_super; TIGR00738 521098002908 Transcriptional regulator; Region: Rrf2; pfam02082 521098002909 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 521098002910 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 521098002911 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 521098002912 active site 521098002913 dimerization interface [polypeptide binding]; other site 521098002914 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 521098002915 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 521098002916 active site 521098002917 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 521098002918 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 521098002919 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 521098002920 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 521098002921 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 521098002922 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 521098002923 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 521098002924 active site 521098002925 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 521098002926 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 521098002927 SNF2 Helicase protein; Region: DUF3670; pfam12419 521098002928 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 521098002929 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521098002930 ATP binding site [chemical binding]; other site 521098002931 putative Mg++ binding site [ion binding]; other site 521098002932 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521098002933 nucleotide binding region [chemical binding]; other site 521098002934 ATP-binding site [chemical binding]; other site 521098002935 Y-family of DNA polymerases; Region: PolY; cl12025 521098002936 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 521098002937 active site 521098002938 DNA binding site [nucleotide binding] 521098002939 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 521098002940 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 521098002941 active site 521098002942 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 521098002943 generic binding surface II; other site 521098002944 generic binding surface I; other site 521098002945 PLD-like domain; Region: PLDc_2; pfam13091 521098002946 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 521098002947 putative active site [active] 521098002948 catalytic site [active] 521098002949 PLD-like domain; Region: PLDc_2; pfam13091 521098002950 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 521098002951 putative active site [active] 521098002952 catalytic site [active] 521098002953 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 521098002954 active site 521098002955 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 521098002956 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 521098002957 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 521098002958 nucleotide binding site/active site [active] 521098002959 HIT family signature motif; other site 521098002960 catalytic residue [active] 521098002961 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 521098002962 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 521098002963 homodimer interface [polypeptide binding]; other site 521098002964 substrate-cofactor binding pocket; other site 521098002965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098002966 catalytic residue [active] 521098002967 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 521098002968 homodimer interface [polypeptide binding]; other site 521098002969 metal binding site [ion binding]; metal-binding site 521098002970 endonuclease IV; Provisional; Region: PRK01060 521098002971 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 521098002972 AP (apurinic/apyrimidinic) site pocket; other site 521098002973 DNA interaction; other site 521098002974 Metal-binding active site; metal-binding site 521098002975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098002976 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521098002977 putative substrate translocation pore; other site 521098002978 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 521098002979 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521098002980 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 521098002981 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 521098002982 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521098002983 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 521098002984 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 521098002985 threonine synthase; Reviewed; Region: PRK06721 521098002986 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 521098002987 homodimer interface [polypeptide binding]; other site 521098002988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098002989 catalytic residue [active] 521098002990 homoserine kinase; Provisional; Region: PRK01212 521098002991 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 521098002992 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 521098002993 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 521098002994 CoenzymeA binding site [chemical binding]; other site 521098002995 subunit interaction site [polypeptide binding]; other site 521098002996 PHB binding site; other site 521098002997 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 521098002998 nudix motif; other site 521098002999 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 521098003000 catalytic triad [active] 521098003001 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 521098003002 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521098003003 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 521098003004 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 521098003005 ArsC family; Region: ArsC; pfam03960 521098003006 catalytic residue [active] 521098003007 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 521098003008 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 521098003009 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 521098003010 cell division protein FtsW; Region: ftsW; TIGR02614 521098003011 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 521098003012 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 521098003013 putative active site [active] 521098003014 catalytic site [active] 521098003015 putative metal binding site [ion binding]; other site 521098003016 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 521098003017 transaminase; Reviewed; Region: PRK08068 521098003018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521098003019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098003020 homodimer interface [polypeptide binding]; other site 521098003021 catalytic residue [active] 521098003022 Stage II sporulation protein; Region: SpoIID; pfam08486 521098003023 YwhD family; Region: YwhD; pfam08741 521098003024 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 521098003025 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 521098003026 homodimer interface [polypeptide binding]; other site 521098003027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098003028 catalytic residue [active] 521098003029 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 521098003030 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 521098003031 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521098003032 catalytic triad [active] 521098003033 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 521098003034 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 521098003035 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521098003036 Zn2+ binding site [ion binding]; other site 521098003037 Mg2+ binding site [ion binding]; other site 521098003038 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 521098003039 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 521098003040 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 521098003041 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 521098003042 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 521098003043 oligomer interface [polypeptide binding]; other site 521098003044 active site 521098003045 metal binding site [ion binding]; metal-binding site 521098003046 Divergent PAP2 family; Region: DUF212; pfam02681 521098003047 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 521098003048 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 521098003049 nudix motif; other site 521098003050 Uncharacterized conserved protein [Function unknown]; Region: COG2445 521098003051 3D domain; Region: 3D; cl01439 521098003052 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 521098003053 NlpC/P60 family; Region: NLPC_P60; cl17555 521098003054 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 521098003055 Integrase core domain; Region: rve; pfam00665 521098003056 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 521098003057 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 521098003058 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521098003059 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 521098003060 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 521098003061 NAD(P) binding site [chemical binding]; other site 521098003062 catalytic residues [active] 521098003063 Small acid-soluble spore protein H family; Region: SspH; pfam08141 521098003064 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 521098003065 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 521098003066 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 521098003067 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 521098003068 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 521098003069 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 521098003070 Int/Topo IB signature motif; other site 521098003071 Domain of unknown function (DUF955); Region: DUF955; cl01076 521098003072 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521098003073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098003074 non-specific DNA binding site [nucleotide binding]; other site 521098003075 salt bridge; other site 521098003076 sequence-specific DNA binding site [nucleotide binding]; other site 521098003077 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521098003078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098003079 non-specific DNA binding site [nucleotide binding]; other site 521098003080 salt bridge; other site 521098003081 sequence-specific DNA binding site [nucleotide binding]; other site 521098003082 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521098003083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098003084 non-specific DNA binding site [nucleotide binding]; other site 521098003085 salt bridge; other site 521098003086 sequence-specific DNA binding site [nucleotide binding]; other site 521098003087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098003088 non-specific DNA binding site [nucleotide binding]; other site 521098003089 salt bridge; other site 521098003090 sequence-specific DNA binding site [nucleotide binding]; other site 521098003091 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521098003092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098003093 non-specific DNA binding site [nucleotide binding]; other site 521098003094 salt bridge; other site 521098003095 sequence-specific DNA binding site [nucleotide binding]; other site 521098003096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098003097 non-specific DNA binding site [nucleotide binding]; other site 521098003098 salt bridge; other site 521098003099 sequence-specific DNA binding site [nucleotide binding]; other site 521098003100 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 521098003101 Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896 521098003102 Phage associated DNA primase [General function prediction only]; Region: COG3378 521098003103 DEAD-like helicases superfamily; Region: DEXDc; smart00487 521098003104 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521098003105 ATP binding site [chemical binding]; other site 521098003106 putative Mg++ binding site [ion binding]; other site 521098003107 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521098003108 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 521098003109 nucleotide binding region [chemical binding]; other site 521098003110 ATP-binding site [chemical binding]; other site 521098003111 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 521098003112 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521098003113 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 521098003114 DNA binding residues [nucleotide binding] 521098003115 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 521098003116 DNA polymerase III subunit beta; Validated; Region: PRK05643 521098003117 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 521098003118 putative DNA binding surface [nucleotide binding]; other site 521098003119 dimer interface [polypeptide binding]; other site 521098003120 beta-clamp/translesion DNA polymerase binding surface; other site 521098003121 beta-clamp/clamp loader binding surface; other site 521098003122 Protein of unknown function (DUF669); Region: DUF669; pfam05037 521098003123 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 521098003124 AAA domain; Region: AAA_18; pfam13238 521098003125 AAA domain; Region: AAA_17; pfam13207 521098003126 exodeoxyribonuclease X; Provisional; Region: PRK07983 521098003127 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 521098003128 active site 521098003129 catalytic site [active] 521098003130 substrate binding site [chemical binding]; other site 521098003131 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 521098003132 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 521098003133 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 521098003134 Cl- selectivity filter; other site 521098003135 Cl- binding residues [ion binding]; other site 521098003136 pore gating glutamate residue; other site 521098003137 dimer interface [polypeptide binding]; other site 521098003138 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521098003139 HAMP domain; Region: HAMP; pfam00672 521098003140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521098003141 dimer interface [polypeptide binding]; other site 521098003142 phosphorylation site [posttranslational modification] 521098003143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098003144 ATP binding site [chemical binding]; other site 521098003145 Mg2+ binding site [ion binding]; other site 521098003146 G-X-G motif; other site 521098003147 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521098003148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098003149 active site 521098003150 phosphorylation site [posttranslational modification] 521098003151 intermolecular recognition site; other site 521098003152 dimerization interface [polypeptide binding]; other site 521098003153 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521098003154 DNA binding site [nucleotide binding] 521098003155 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 521098003156 Multicopper oxidase; Region: Cu-oxidase; pfam00394 521098003157 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 521098003158 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 521098003159 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 521098003160 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521098003161 catalytic residues [active] 521098003162 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 521098003163 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 521098003164 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 521098003165 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 521098003166 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 521098003167 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 521098003168 putative homodimer interface [polypeptide binding]; other site 521098003169 putative homotetramer interface [polypeptide binding]; other site 521098003170 putative allosteric switch controlling residues; other site 521098003171 putative metal binding site [ion binding]; other site 521098003172 putative homodimer-homodimer interface [polypeptide binding]; other site 521098003173 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 521098003174 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 521098003175 metal-binding site [ion binding] 521098003176 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 521098003177 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 521098003178 metal-binding site [ion binding] 521098003179 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521098003180 Soluble P-type ATPase [General function prediction only]; Region: COG4087 521098003181 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 521098003182 metal-binding site [ion binding] 521098003183 Short C-terminal domain; Region: SHOCT; pfam09851 521098003184 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 521098003185 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 521098003186 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 521098003187 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 521098003188 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 521098003189 putative dimer interface [polypeptide binding]; other site 521098003190 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521098003191 ligand binding site [chemical binding]; other site 521098003192 Zn binding site [ion binding]; other site 521098003193 Cation efflux family; Region: Cation_efflux; cl00316 521098003194 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 521098003195 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 521098003196 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521098003197 dimerization interface [polypeptide binding]; other site 521098003198 putative DNA binding site [nucleotide binding]; other site 521098003199 putative Zn2+ binding site [ion binding]; other site 521098003200 YolD-like protein; Region: YolD; pfam08863 521098003201 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 521098003202 dimerization interface [polypeptide binding]; other site 521098003203 putative active site pocket [active] 521098003204 putative catalytic residue [active] 521098003205 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 521098003206 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 521098003207 cofactor binding site; other site 521098003208 DNA binding site [nucleotide binding] 521098003209 substrate interaction site [chemical binding]; other site 521098003210 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 521098003211 Catalytic GIY-YIG domain of type II restriction enzyme R.Cfr42I and similar proteins; Region: GIY-YIG_RE_Cfr42I; cd10453 521098003212 GIY-YIG motif/motif A; other site 521098003213 putative active site [active] 521098003214 putative metal binding site [ion binding]; other site 521098003215 Protein of unknown function (DUF433); Region: DUF433; cl01030 521098003216 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 521098003217 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 521098003218 active site 521098003219 RNA polymerase factor sigma-70; Validated; Region: PRK08295 521098003220 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521098003221 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 521098003222 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 521098003223 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 521098003224 putative active site pocket [active] 521098003225 dimerization interface [polypeptide binding]; other site 521098003226 putative catalytic residue [active] 521098003227 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 521098003228 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 521098003229 ParB-like nuclease domain; Region: ParB; smart00470 521098003230 ParB-like nuclease domain; Region: ParB; smart00470 521098003231 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 521098003232 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 521098003233 Probable transposase; Region: OrfB_IS605; pfam01385 521098003234 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 521098003235 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 521098003236 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 521098003237 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 521098003238 BRO family, N-terminal domain; Region: Bro-N; smart01040 521098003239 positive control sigma-like factor; Validated; Region: PRK06930 521098003240 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 521098003241 DNA binding residues [nucleotide binding] 521098003242 dimerization interface [polypeptide binding]; other site 521098003243 AAA-like domain; Region: AAA_10; pfam12846 521098003244 Domain of unknown function DUF20; Region: UPF0118; pfam01594 521098003245 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 521098003246 Brain acid soluble protein 1 (BASP1 protein); Region: BASP1; pfam05466 521098003247 TcpE family; Region: TcpE; pfam12648 521098003248 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 521098003249 N-acetyl-D-glucosamine binding site [chemical binding]; other site 521098003250 catalytic residue [active] 521098003251 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 521098003252 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 521098003253 metal binding site [ion binding]; metal-binding site 521098003254 active site 521098003255 I-site; other site 521098003256 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521098003257 Zn2+ binding site [ion binding]; other site 521098003258 Mg2+ binding site [ion binding]; other site 521098003259 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 521098003260 Phospholipid methyltransferase; Region: PEMT; cl17370 521098003261 Domain of unknown function DUF87; Region: DUF87; pfam01935 521098003262 AAA-like domain; Region: AAA_10; pfam12846 521098003263 Replication-relaxation; Region: Replic_Relax; pfam13814 521098003264 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 521098003265 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 521098003266 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 521098003267 IHF - DNA interface [nucleotide binding]; other site 521098003268 IHF dimer interface [polypeptide binding]; other site 521098003269 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 521098003270 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521098003271 P-loop; other site 521098003272 Magnesium ion binding site [ion binding]; other site 521098003273 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 521098003274 Mg binding site [ion binding]; other site 521098003275 nucleotide binding site [chemical binding]; other site 521098003276 putative protofilament interface [polypeptide binding]; other site 521098003277 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 521098003278 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 521098003279 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 521098003280 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521098003281 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 521098003282 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 521098003283 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 521098003284 Walker A motif; other site 521098003285 ATP binding site [chemical binding]; other site 521098003286 Walker B motif; other site 521098003287 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 521098003288 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 521098003289 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 521098003290 putative active site pocket [active] 521098003291 dimerization interface [polypeptide binding]; other site 521098003292 putative catalytic residue [active] 521098003293 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 521098003294 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 521098003295 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 521098003296 putative active site [active] 521098003297 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 521098003298 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 521098003299 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 521098003300 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 521098003301 active site 521098003302 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 521098003303 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 521098003304 substrate binding site [chemical binding]; other site 521098003305 oxyanion hole (OAH) forming residues; other site 521098003306 trimer interface [polypeptide binding]; other site 521098003307 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 521098003308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521098003309 NAD(P) binding site [chemical binding]; other site 521098003310 active site 521098003311 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 521098003312 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521098003313 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521098003314 DNA binding site [nucleotide binding] 521098003315 domain linker motif; other site 521098003316 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 521098003317 ligand binding site [chemical binding]; other site 521098003318 dimerization interface [polypeptide binding]; other site 521098003319 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 521098003320 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 521098003321 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 521098003322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098003323 dimer interface [polypeptide binding]; other site 521098003324 putative PBP binding loops; other site 521098003325 ABC-ATPase subunit interface; other site 521098003326 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 521098003327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098003328 dimer interface [polypeptide binding]; other site 521098003329 conserved gate region; other site 521098003330 putative PBP binding loops; other site 521098003331 ABC-ATPase subunit interface; other site 521098003332 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 521098003333 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 521098003334 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 521098003335 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 521098003336 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 521098003337 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 521098003338 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 521098003339 glutamine binding [chemical binding]; other site 521098003340 catalytic triad [active] 521098003341 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 521098003342 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 521098003343 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 521098003344 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 521098003345 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 521098003346 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 521098003347 nucleotide binding site [chemical binding]; other site 521098003348 N-acetyl-L-glutamate binding site [chemical binding]; other site 521098003349 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 521098003350 acetylornithine aminotransferase; Provisional; Region: PRK02627 521098003351 inhibitor-cofactor binding pocket; inhibition site 521098003352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098003353 catalytic residue [active] 521098003354 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 521098003355 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521098003356 Coenzyme A binding pocket [chemical binding]; other site 521098003357 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 521098003358 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 521098003359 active site 521098003360 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 521098003361 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 521098003362 active site 521098003363 FMN binding site [chemical binding]; other site 521098003364 substrate binding site [chemical binding]; other site 521098003365 3Fe-4S cluster binding site [ion binding]; other site 521098003366 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 521098003367 domain_subunit interface; other site 521098003368 ornithine carbamoyltransferase; Provisional; Region: PRK00779 521098003369 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 521098003370 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 521098003371 argininosuccinate synthase; Provisional; Region: PRK13820 521098003372 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 521098003373 ANP binding site [chemical binding]; other site 521098003374 Substrate Binding Site II [chemical binding]; other site 521098003375 Substrate Binding Site I [chemical binding]; other site 521098003376 argininosuccinate lyase; Provisional; Region: PRK00855 521098003377 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 521098003378 active sites [active] 521098003379 tetramer interface [polypeptide binding]; other site 521098003380 aspartate kinase; Reviewed; Region: PRK06635 521098003381 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 521098003382 putative nucleotide binding site [chemical binding]; other site 521098003383 putative catalytic residues [active] 521098003384 putative Mg ion binding site [ion binding]; other site 521098003385 putative aspartate binding site [chemical binding]; other site 521098003386 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 521098003387 putative allosteric regulatory site; other site 521098003388 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 521098003389 putative allosteric regulatory residue; other site 521098003390 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 521098003391 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 521098003392 ligand binding site [chemical binding]; other site 521098003393 NAD binding site [chemical binding]; other site 521098003394 dimerization interface [polypeptide binding]; other site 521098003395 catalytic site [active] 521098003396 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 521098003397 putative L-serine binding site [chemical binding]; other site 521098003398 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 521098003399 homodimer interface [polypeptide binding]; other site 521098003400 substrate-cofactor binding pocket; other site 521098003401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098003402 catalytic residue [active] 521098003403 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 521098003404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521098003405 motif II; other site 521098003406 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521098003407 ATP binding site [chemical binding]; other site 521098003408 putative Mg++ binding site [ion binding]; other site 521098003409 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 521098003410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521098003411 nucleotide binding region [chemical binding]; other site 521098003412 ATP-binding site [chemical binding]; other site 521098003413 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 521098003414 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 521098003415 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 521098003416 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 521098003417 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 521098003418 Protein of unknown function (DUF499); Region: DUF499; pfam04465 521098003419 SIR2-like domain; Region: SIR2_2; pfam13289 521098003420 Domain of unknown function DUF87; Region: DUF87; pfam01935 521098003421 AAA-like domain; Region: AAA_10; pfam12846 521098003422 Transposase [DNA replication, recombination, and repair]; Region: COG5421 521098003423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521098003424 DNA-binding site [nucleotide binding]; DNA binding site 521098003425 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 521098003426 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 521098003427 Walker A/P-loop; other site 521098003428 ATP binding site [chemical binding]; other site 521098003429 Q-loop/lid; other site 521098003430 ABC transporter signature motif; other site 521098003431 Walker B; other site 521098003432 D-loop; other site 521098003433 H-loop/switch region; other site 521098003434 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 521098003435 active site residue [active] 521098003436 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 521098003437 catalytic residues [active] 521098003438 Domain of unknown function DUF302; Region: DUF302; cl01364 521098003439 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 521098003440 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 521098003441 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 521098003442 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 521098003443 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 521098003444 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 521098003445 Transcriptional regulators [Transcription]; Region: GntR; COG1802 521098003446 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521098003447 DNA-binding site [nucleotide binding]; DNA binding site 521098003448 FCD domain; Region: FCD; pfam07729 521098003449 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 521098003450 acetyl-CoA synthetase; Provisional; Region: PRK00174 521098003451 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 521098003452 active site 521098003453 CoA binding site [chemical binding]; other site 521098003454 acyl-activating enzyme (AAE) consensus motif; other site 521098003455 AMP binding site [chemical binding]; other site 521098003456 acetate binding site [chemical binding]; other site 521098003457 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 521098003458 Protein of unknown function (DUF964); Region: DUF964; pfam06133 521098003459 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 521098003460 Clp protease; Region: CLP_protease; pfam00574 521098003461 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 521098003462 oligomer interface [polypeptide binding]; other site 521098003463 active site residues [active] 521098003464 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 521098003465 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 521098003466 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521098003467 catalytic residue [active] 521098003468 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 521098003469 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 521098003470 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 521098003471 Ligand Binding Site [chemical binding]; other site 521098003472 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 521098003473 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 521098003474 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 521098003475 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 521098003476 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 521098003477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521098003478 NAD(P) binding site [chemical binding]; other site 521098003479 active site 521098003480 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 521098003481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 521098003482 cell division protein MraZ; Reviewed; Region: PRK00326 521098003483 MraZ protein; Region: MraZ; pfam02381 521098003484 MraZ protein; Region: MraZ; pfam02381 521098003485 MraW methylase family; Region: Methyltransf_5; pfam01795 521098003486 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 521098003487 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 521098003488 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521098003489 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 521098003490 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 521098003491 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 521098003492 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 521098003493 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521098003494 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 521098003495 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 521098003496 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 521098003497 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521098003498 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521098003499 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521098003500 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 521098003501 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 521098003502 Mg++ binding site [ion binding]; other site 521098003503 putative catalytic motif [active] 521098003504 putative substrate binding site [chemical binding]; other site 521098003505 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 521098003506 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521098003507 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521098003508 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 521098003509 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 521098003510 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 521098003511 active site 521098003512 homodimer interface [polypeptide binding]; other site 521098003513 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 521098003514 FAD binding domain; Region: FAD_binding_4; pfam01565 521098003515 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 521098003516 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 521098003517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 521098003518 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 521098003519 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 521098003520 catalytic residues [active] 521098003521 catalytic nucleophile [active] 521098003522 Presynaptic Site I dimer interface [polypeptide binding]; other site 521098003523 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 521098003524 Synaptic Flat tetramer interface [polypeptide binding]; other site 521098003525 Synaptic Site I dimer interface [polypeptide binding]; other site 521098003526 DNA binding site [nucleotide binding] 521098003527 Recombinase; Region: Recombinase; pfam07508 521098003528 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 521098003529 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 521098003530 Cell division protein FtsQ; Region: FtsQ; pfam03799 521098003531 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 521098003532 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 521098003533 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 521098003534 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 521098003535 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 521098003536 nucleotide binding site [chemical binding]; other site 521098003537 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 521098003538 Cell division protein FtsA; Region: FtsA; pfam14450 521098003539 cell division protein FtsZ; Validated; Region: PRK09330 521098003540 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 521098003541 nucleotide binding site [chemical binding]; other site 521098003542 SulA interaction site; other site 521098003543 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 521098003544 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 521098003545 sporulation sigma factor SigE; Reviewed; Region: PRK08301 521098003546 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521098003547 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521098003548 DNA binding residues [nucleotide binding] 521098003549 sporulation sigma factor SigG; Reviewed; Region: PRK08215 521098003550 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521098003551 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 521098003552 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521098003553 DNA binding residues [nucleotide binding] 521098003554 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 521098003555 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 521098003556 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 521098003557 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 521098003558 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521098003559 catalytic residue [active] 521098003560 YGGT family; Region: YGGT; pfam02325 521098003561 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 521098003562 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 521098003563 DivIVA protein; Region: DivIVA; pfam05103 521098003564 DivIVA domain; Region: DivI1A_domain; TIGR03544 521098003565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 521098003566 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 521098003567 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 521098003568 lipoprotein signal peptidase; Provisional; Region: PRK14787 521098003569 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 521098003570 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521098003571 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 521098003572 active site 521098003573 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 521098003574 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521098003575 active site 521098003576 aspartate carbamoyltransferase; Region: PLN02527 521098003577 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 521098003578 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 521098003579 dihydroorotase; Validated; Region: pyrC; PRK09357 521098003580 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521098003581 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 521098003582 active site 521098003583 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 521098003584 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 521098003585 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 521098003586 catalytic site [active] 521098003587 subunit interface [polypeptide binding]; other site 521098003588 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 521098003589 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 521098003590 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 521098003591 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 521098003592 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 521098003593 ATP-grasp domain; Region: ATP-grasp_4; cl17255 521098003594 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 521098003595 IMP binding site; other site 521098003596 dimer interface [polypeptide binding]; other site 521098003597 interdomain contacts; other site 521098003598 partial ornithine binding site; other site 521098003599 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 521098003600 active site 521098003601 dimer interface [polypeptide binding]; other site 521098003602 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521098003603 active site 521098003604 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 521098003605 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 521098003606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098003607 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521098003608 putative substrate translocation pore; other site 521098003609 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 521098003610 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 521098003611 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 521098003612 NAD(P) binding site [chemical binding]; other site 521098003613 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 521098003614 Domain of unknown function (DUF814); Region: DUF814; pfam05670 521098003615 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 521098003616 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 521098003617 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521098003618 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 521098003619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521098003620 motif II; other site 521098003621 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 521098003622 hypothetical protein; Provisional; Region: PRK11820 521098003623 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 521098003624 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 521098003625 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 521098003626 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 521098003627 Flavoprotein; Region: Flavoprotein; pfam02441 521098003628 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 521098003629 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521098003630 primosomal protein N' Region: priA; TIGR00595 521098003631 ATP binding site [chemical binding]; other site 521098003632 putative Mg++ binding site [ion binding]; other site 521098003633 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521098003634 nucleotide binding region [chemical binding]; other site 521098003635 ATP-binding site [chemical binding]; other site 521098003636 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 521098003637 active site 521098003638 catalytic residues [active] 521098003639 metal binding site [ion binding]; metal-binding site 521098003640 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 521098003641 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 521098003642 putative active site [active] 521098003643 substrate binding site [chemical binding]; other site 521098003644 putative cosubstrate binding site; other site 521098003645 catalytic site [active] 521098003646 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 521098003647 substrate binding site [chemical binding]; other site 521098003648 16S rRNA methyltransferase B; Provisional; Region: PRK14902 521098003649 NusB family; Region: NusB; pfam01029 521098003650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098003651 S-adenosylmethionine binding site [chemical binding]; other site 521098003652 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 521098003653 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521098003654 FeS/SAM binding site; other site 521098003655 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 521098003656 active site 521098003657 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 521098003658 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521098003659 active site 521098003660 ATP binding site [chemical binding]; other site 521098003661 substrate binding site [chemical binding]; other site 521098003662 activation loop (A-loop); other site 521098003663 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 521098003664 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 521098003665 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 521098003666 GTPase RsgA; Reviewed; Region: PRK00098 521098003667 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 521098003668 RNA binding site [nucleotide binding]; other site 521098003669 homodimer interface [polypeptide binding]; other site 521098003670 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 521098003671 GTPase/Zn-binding domain interface [polypeptide binding]; other site 521098003672 GTP/Mg2+ binding site [chemical binding]; other site 521098003673 G4 box; other site 521098003674 G5 box; other site 521098003675 G1 box; other site 521098003676 Switch I region; other site 521098003677 G2 box; other site 521098003678 G3 box; other site 521098003679 Switch II region; other site 521098003680 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 521098003681 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 521098003682 substrate binding site [chemical binding]; other site 521098003683 hexamer interface [polypeptide binding]; other site 521098003684 metal binding site [ion binding]; metal-binding site 521098003685 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 521098003686 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 521098003687 Y-family of DNA polymerases; Region: PolY; cl12025 521098003688 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 521098003689 generic binding surface I; other site 521098003690 generic binding surface II; other site 521098003691 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521098003692 ATP binding site [chemical binding]; other site 521098003693 putative Mg++ binding site [ion binding]; other site 521098003694 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521098003695 nucleotide binding region [chemical binding]; other site 521098003696 ATP-binding site [chemical binding]; other site 521098003697 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 521098003698 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 521098003699 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 521098003700 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 521098003701 NAD binding site [chemical binding]; other site 521098003702 substrate binding site [chemical binding]; other site 521098003703 active site 521098003704 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521098003705 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 521098003706 amidase; Provisional; Region: PRK09201 521098003707 Amidase; Region: Amidase; pfam01425 521098003708 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 521098003709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098003710 S-adenosylmethionine binding site [chemical binding]; other site 521098003711 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 521098003712 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 521098003713 active site 521098003714 (T/H)XGH motif; other site 521098003715 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 521098003716 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 521098003717 active site 521098003718 nucleophile elbow; other site 521098003719 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 521098003720 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 521098003721 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 521098003722 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 521098003723 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 521098003724 active site 2 [active] 521098003725 putative phosphate acyltransferase; Provisional; Region: PRK05331 521098003726 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 521098003727 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 521098003728 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 521098003729 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 521098003730 NAD(P) binding site [chemical binding]; other site 521098003731 homotetramer interface [polypeptide binding]; other site 521098003732 homodimer interface [polypeptide binding]; other site 521098003733 active site 521098003734 acyl carrier protein; Provisional; Region: acpP; PRK00982 521098003735 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 521098003736 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 521098003737 dimer interface [polypeptide binding]; other site 521098003738 active site 521098003739 ribonuclease III; Reviewed; Region: rnc; PRK00102 521098003740 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 521098003741 dimerization interface [polypeptide binding]; other site 521098003742 active site 521098003743 metal binding site [ion binding]; metal-binding site 521098003744 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 521098003745 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 521098003746 AAA domain; Region: AAA_23; pfam13476 521098003747 Walker A/P-loop; other site 521098003748 ATP binding site [chemical binding]; other site 521098003749 Q-loop/lid; other site 521098003750 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 521098003751 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 521098003752 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 521098003753 ABC transporter signature motif; other site 521098003754 Walker B; other site 521098003755 D-loop; other site 521098003756 H-loop/switch region; other site 521098003757 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 521098003758 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 521098003759 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 521098003760 P loop; other site 521098003761 GTP binding site [chemical binding]; other site 521098003762 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521098003763 DNA binding residues [nucleotide binding] 521098003764 signal recognition particle protein; Provisional; Region: PRK10867 521098003765 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 521098003766 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 521098003767 P loop; other site 521098003768 GTP binding site [chemical binding]; other site 521098003769 Signal peptide binding domain; Region: SRP_SPB; pfam02978 521098003770 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 521098003771 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 521098003772 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 521098003773 G-X-X-G motif; other site 521098003774 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 521098003775 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 521098003776 RimM N-terminal domain; Region: RimM; pfam01782 521098003777 PRC-barrel domain; Region: PRC; pfam05239 521098003778 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 521098003779 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 521098003780 chorismate binding enzyme; Region: Chorismate_bind; cl10555 521098003781 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 521098003782 substrate-cofactor binding pocket; other site 521098003783 homodimer interface [polypeptide binding]; other site 521098003784 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 521098003785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098003786 catalytic residue [active] 521098003787 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521098003788 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 521098003789 RNA binding surface [nucleotide binding]; other site 521098003790 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 521098003791 active site 521098003792 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 521098003793 active site 521098003794 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 521098003795 Peptidase family M23; Region: Peptidase_M23; pfam01551 521098003796 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 521098003797 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 521098003798 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 521098003799 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 521098003800 GTP/Mg2+ binding site [chemical binding]; other site 521098003801 G4 box; other site 521098003802 G5 box; other site 521098003803 G1 box; other site 521098003804 Switch I region; other site 521098003805 G2 box; other site 521098003806 G3 box; other site 521098003807 Switch II region; other site 521098003808 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 521098003809 RNA/DNA hybrid binding site [nucleotide binding]; other site 521098003810 active site 521098003811 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 521098003812 hypothetical protein; Reviewed; Region: PRK12497 521098003813 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 521098003814 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 521098003815 NodB motif; other site 521098003816 active site 521098003817 catalytic site [active] 521098003818 metal binding site [ion binding]; metal-binding site 521098003819 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 521098003820 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 521098003821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098003822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 521098003823 Walker A motif; other site 521098003824 ATP binding site [chemical binding]; other site 521098003825 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 521098003826 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 521098003827 CoA-ligase; Region: Ligase_CoA; pfam00549 521098003828 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 521098003829 CoA binding domain; Region: CoA_binding; smart00881 521098003830 CoA-ligase; Region: Ligase_CoA; pfam00549 521098003831 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 521098003832 DNA protecting protein DprA; Region: dprA; TIGR00732 521098003833 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 521098003834 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 521098003835 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 521098003836 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521098003837 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521098003838 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 521098003839 Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690 521098003840 DNA topoisomerase I; Validated; Region: PRK05582 521098003841 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 521098003842 active site 521098003843 interdomain interaction site; other site 521098003844 putative metal-binding site [ion binding]; other site 521098003845 nucleotide binding site [chemical binding]; other site 521098003846 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 521098003847 domain I; other site 521098003848 DNA binding groove [nucleotide binding] 521098003849 phosphate binding site [ion binding]; other site 521098003850 domain II; other site 521098003851 domain III; other site 521098003852 nucleotide binding site [chemical binding]; other site 521098003853 catalytic site [active] 521098003854 domain IV; other site 521098003855 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 521098003856 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 521098003857 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 521098003858 Glucose inhibited division protein A; Region: GIDA; pfam01134 521098003859 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 521098003860 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 521098003861 active site 521098003862 DNA binding site [nucleotide binding] 521098003863 Int/Topo IB signature motif; other site 521098003864 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 521098003865 active site 521098003866 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 521098003867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098003868 Walker A motif; other site 521098003869 ATP binding site [chemical binding]; other site 521098003870 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 521098003871 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 521098003872 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 521098003873 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 521098003874 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 521098003875 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 521098003876 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 521098003877 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 521098003878 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 521098003879 FliG C-terminal domain; Region: FliG_C; pfam01706 521098003880 Flagellar assembly protein FliH; Region: FliH; pfam02108 521098003881 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 521098003882 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 521098003883 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 521098003884 Walker A motif/ATP binding site; other site 521098003885 Walker B motif; other site 521098003886 MgtE intracellular N domain; Region: MgtE_N; pfam03448 521098003887 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 521098003888 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 521098003889 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 521098003890 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 521098003891 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 521098003892 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 521098003893 Flagellar protein (FlbD); Region: FlbD; pfam06289 521098003894 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 521098003895 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 521098003896 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 521098003897 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 521098003898 flagellar motor switch protein; Validated; Region: PRK08119 521098003899 CheC-like family; Region: CheC; pfam04509 521098003900 CheC-like family; Region: CheC; pfam04509 521098003901 flagellar motor switch protein FliN; Region: fliN; TIGR02480 521098003902 Response regulator receiver domain; Region: Response_reg; pfam00072 521098003903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098003904 active site 521098003905 phosphorylation site [posttranslational modification] 521098003906 intermolecular recognition site; other site 521098003907 dimerization interface [polypeptide binding]; other site 521098003908 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 521098003909 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 521098003910 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 521098003911 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 521098003912 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 521098003913 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 521098003914 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 521098003915 FHIPEP family; Region: FHIPEP; pfam00771 521098003916 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 521098003917 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521098003918 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521098003919 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521098003920 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 521098003921 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 521098003922 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 521098003923 putative binding surface; other site 521098003924 active site 521098003925 P2 response regulator binding domain; Region: P2; pfam07194 521098003926 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 521098003927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098003928 ATP binding site [chemical binding]; other site 521098003929 Mg2+ binding site [ion binding]; other site 521098003930 G-X-G motif; other site 521098003931 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 521098003932 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 521098003933 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 521098003934 CheC-like family; Region: CheC; pfam04509 521098003935 CheC-like family; Region: CheC; pfam04509 521098003936 CheD chemotactic sensory transduction; Region: CheD; cl00810 521098003937 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 521098003938 rRNA interaction site [nucleotide binding]; other site 521098003939 S8 interaction site; other site 521098003940 putative laminin-1 binding site; other site 521098003941 elongation factor Ts; Reviewed; Region: tsf; PRK12332 521098003942 UBA/TS-N domain; Region: UBA; pfam00627 521098003943 Elongation factor TS; Region: EF_TS; pfam00889 521098003944 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 521098003945 putative nucleotide binding site [chemical binding]; other site 521098003946 uridine monophosphate binding site [chemical binding]; other site 521098003947 homohexameric interface [polypeptide binding]; other site 521098003948 ribosome recycling factor; Reviewed; Region: frr; PRK00083 521098003949 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 521098003950 hinge region; other site 521098003951 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 521098003952 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 521098003953 catalytic residue [active] 521098003954 putative FPP diphosphate binding site; other site 521098003955 putative FPP binding hydrophobic cleft; other site 521098003956 dimer interface [polypeptide binding]; other site 521098003957 putative IPP diphosphate binding site; other site 521098003958 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 521098003959 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 521098003960 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 521098003961 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 521098003962 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 521098003963 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 521098003964 RIP metalloprotease RseP; Region: TIGR00054 521098003965 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 521098003966 active site 521098003967 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 521098003968 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 521098003969 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 521098003970 DNA polymerase III PolC; Validated; Region: polC; PRK00448 521098003971 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 521098003972 generic binding surface II; other site 521098003973 generic binding surface I; other site 521098003974 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 521098003975 active site 521098003976 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 521098003977 active site 521098003978 catalytic site [active] 521098003979 substrate binding site [chemical binding]; other site 521098003980 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 521098003981 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521098003982 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 521098003983 active site 521098003984 metal binding site [ion binding]; metal-binding site 521098003985 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 521098003986 Prephenate dehydratase; Region: PDT; pfam00800 521098003987 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 521098003988 putative L-Phe binding site [chemical binding]; other site 521098003989 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 521098003990 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 521098003991 G1 box; other site 521098003992 putative GEF interaction site [polypeptide binding]; other site 521098003993 GTP/Mg2+ binding site [chemical binding]; other site 521098003994 Switch I region; other site 521098003995 G2 box; other site 521098003996 G3 box; other site 521098003997 Switch II region; other site 521098003998 G4 box; other site 521098003999 G5 box; other site 521098004000 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 521098004001 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 521098004002 Sm and related proteins; Region: Sm_like; cl00259 521098004003 ribosome maturation protein RimP; Reviewed; Region: PRK00092 521098004004 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 521098004005 putative oligomer interface [polypeptide binding]; other site 521098004006 putative RNA binding site [nucleotide binding]; other site 521098004007 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 521098004008 NusA N-terminal domain; Region: NusA_N; pfam08529 521098004009 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 521098004010 RNA binding site [nucleotide binding]; other site 521098004011 homodimer interface [polypeptide binding]; other site 521098004012 NusA-like KH domain; Region: KH_5; pfam13184 521098004013 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 521098004014 G-X-X-G motif; other site 521098004015 Protein of unknown function (DUF448); Region: DUF448; pfam04296 521098004016 putative RNA binding cleft [nucleotide binding]; other site 521098004017 translation initiation factor IF-2; Validated; Region: infB; PRK05306 521098004018 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 521098004019 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 521098004020 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 521098004021 G1 box; other site 521098004022 putative GEF interaction site [polypeptide binding]; other site 521098004023 GTP/Mg2+ binding site [chemical binding]; other site 521098004024 Switch I region; other site 521098004025 G2 box; other site 521098004026 G3 box; other site 521098004027 Switch II region; other site 521098004028 G4 box; other site 521098004029 G5 box; other site 521098004030 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 521098004031 Translation-initiation factor 2; Region: IF-2; pfam11987 521098004032 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 521098004033 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 521098004034 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 521098004035 DHH family; Region: DHH; pfam01368 521098004036 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 521098004037 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 521098004038 RNA binding site [nucleotide binding]; other site 521098004039 active site 521098004040 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 521098004041 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 521098004042 active site 521098004043 Riboflavin kinase; Region: Flavokinase; pfam01687 521098004044 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 521098004045 putative active site pocket [active] 521098004046 dimerization interface [polypeptide binding]; other site 521098004047 putative catalytic residue [active] 521098004048 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 521098004049 16S/18S rRNA binding site [nucleotide binding]; other site 521098004050 S13e-L30e interaction site [polypeptide binding]; other site 521098004051 25S rRNA binding site [nucleotide binding]; other site 521098004052 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 521098004053 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 521098004054 RNase E interface [polypeptide binding]; other site 521098004055 trimer interface [polypeptide binding]; other site 521098004056 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 521098004057 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 521098004058 RNase E interface [polypeptide binding]; other site 521098004059 trimer interface [polypeptide binding]; other site 521098004060 active site 521098004061 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 521098004062 putative nucleic acid binding region [nucleotide binding]; other site 521098004063 G-X-X-G motif; other site 521098004064 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 521098004065 RNA binding site [nucleotide binding]; other site 521098004066 domain interface; other site 521098004067 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 521098004068 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 521098004069 NodB motif; other site 521098004070 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 521098004071 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 521098004072 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521098004073 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 521098004074 trimer interface [polypeptide binding]; other site 521098004075 active site 521098004076 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 521098004077 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 521098004078 NAD binding site [chemical binding]; other site 521098004079 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 521098004080 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 521098004081 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 521098004082 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 521098004083 aspartate kinase I; Reviewed; Region: PRK08210 521098004084 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 521098004085 nucleotide binding site [chemical binding]; other site 521098004086 substrate binding site [chemical binding]; other site 521098004087 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 521098004088 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 521098004089 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 521098004090 dihydrodipicolinate synthase; Region: dapA; TIGR00674 521098004091 dimer interface [polypeptide binding]; other site 521098004092 active site 521098004093 catalytic residue [active] 521098004094 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 521098004095 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 521098004096 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 521098004097 putative RNA binding site [nucleotide binding]; other site 521098004098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098004099 S-adenosylmethionine binding site [chemical binding]; other site 521098004100 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 521098004101 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 521098004102 active site 521098004103 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 521098004104 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 521098004105 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 521098004106 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 521098004107 tetrameric interface [polypeptide binding]; other site 521098004108 NAD binding site [chemical binding]; other site 521098004109 catalytic residues [active] 521098004110 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 521098004111 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 521098004112 substrate binding site [chemical binding]; other site 521098004113 oxyanion hole (OAH) forming residues; other site 521098004114 trimer interface [polypeptide binding]; other site 521098004115 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 521098004116 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 521098004117 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 521098004118 active site 521098004119 acyl-activating enzyme (AAE) consensus motif; other site 521098004120 putative CoA binding site [chemical binding]; other site 521098004121 AMP binding site [chemical binding]; other site 521098004122 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 521098004123 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 521098004124 dimer interface [polypeptide binding]; other site 521098004125 active site 521098004126 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 521098004127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521098004128 NAD(P) binding site [chemical binding]; other site 521098004129 active site 521098004130 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 521098004131 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 521098004132 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 521098004133 NAD binding site [chemical binding]; other site 521098004134 Phe binding site; other site 521098004135 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 521098004136 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 521098004137 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 521098004138 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 521098004139 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 521098004140 active site 521098004141 YlzJ-like protein; Region: YlzJ; pfam14035 521098004142 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 521098004143 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 521098004144 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 521098004145 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 521098004146 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 521098004147 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 521098004148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098004149 non-specific DNA binding site [nucleotide binding]; other site 521098004150 salt bridge; other site 521098004151 sequence-specific DNA binding site [nucleotide binding]; other site 521098004152 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 521098004153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 521098004154 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 521098004155 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 521098004156 competence damage-inducible protein A; Provisional; Region: PRK00549 521098004157 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 521098004158 putative MPT binding site; other site 521098004159 Competence-damaged protein; Region: CinA; pfam02464 521098004160 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 521098004161 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 521098004162 ATP binding site [chemical binding]; other site 521098004163 Mg++ binding site [ion binding]; other site 521098004164 motif III; other site 521098004165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521098004166 nucleotide binding region [chemical binding]; other site 521098004167 ATP-binding site [chemical binding]; other site 521098004168 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 521098004169 RNA binding site [nucleotide binding]; other site 521098004170 recombinase A; Provisional; Region: recA; PRK09354 521098004171 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 521098004172 hexamer interface [polypeptide binding]; other site 521098004173 Walker A motif; other site 521098004174 ATP binding site [chemical binding]; other site 521098004175 Walker B motif; other site 521098004176 recombination regulator RecX; Reviewed; Region: recX; PRK00117 521098004177 phosphodiesterase; Provisional; Region: PRK12704 521098004178 uncharacterized domain HDIG; Region: HDIG; TIGR00277 521098004179 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 521098004180 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 521098004181 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 521098004182 active site 521098004183 dimer interface [polypeptide binding]; other site 521098004184 Outer spore coat protein E (CotE); Region: CotE; pfam10628 521098004185 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 521098004186 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 521098004187 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 521098004188 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 521098004189 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 521098004190 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 521098004191 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521098004192 FeS/SAM binding site; other site 521098004193 TRAM domain; Region: TRAM; pfam01938 521098004194 Protein of unknown function (DUF964); Region: DUF964; pfam06133 521098004195 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 521098004196 MutS domain I; Region: MutS_I; pfam01624 521098004197 MutS domain II; Region: MutS_II; pfam05188 521098004198 MutS domain III; Region: MutS_III; pfam05192 521098004199 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 521098004200 Walker A/P-loop; other site 521098004201 ATP binding site [chemical binding]; other site 521098004202 Q-loop/lid; other site 521098004203 ABC transporter signature motif; other site 521098004204 Walker B; other site 521098004205 D-loop; other site 521098004206 H-loop/switch region; other site 521098004207 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 521098004208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098004209 ATP binding site [chemical binding]; other site 521098004210 Mg2+ binding site [ion binding]; other site 521098004211 G-X-G motif; other site 521098004212 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 521098004213 ATP binding site [chemical binding]; other site 521098004214 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 521098004215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098004216 S-adenosylmethionine binding site [chemical binding]; other site 521098004217 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 521098004218 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 521098004219 bacterial Hfq-like; Region: Hfq; cd01716 521098004220 hexamer interface [polypeptide binding]; other site 521098004221 Sm1 motif; other site 521098004222 RNA binding site [nucleotide binding]; other site 521098004223 Sm2 motif; other site 521098004224 Protein of unknown function (DUF669); Region: DUF669; pfam05037 521098004225 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 521098004226 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 521098004227 RRXRR protein; Region: RRXRR; pfam14239 521098004228 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 521098004229 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 521098004230 active site 521098004231 exodeoxyribonuclease X; Provisional; Region: PRK07983 521098004232 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 521098004233 active site 521098004234 catalytic site [active] 521098004235 substrate binding site [chemical binding]; other site 521098004236 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 521098004237 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 521098004238 DNA binding residues [nucleotide binding] 521098004239 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 521098004240 putative active site [active] 521098004241 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521098004242 HlyD family secretion protein; Region: HlyD_2; pfam12700 521098004243 HlyD family secretion protein; Region: HlyD_3; pfam13437 521098004244 putative membrane fusion protein; Region: TIGR02828 521098004245 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521098004246 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521098004247 Walker A/P-loop; other site 521098004248 ATP binding site [chemical binding]; other site 521098004249 Q-loop/lid; other site 521098004250 ABC transporter signature motif; other site 521098004251 Walker B; other site 521098004252 D-loop; other site 521098004253 H-loop/switch region; other site 521098004254 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521098004255 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 521098004256 FtsX-like permease family; Region: FtsX; pfam02687 521098004257 transposase/IS protein; Provisional; Region: PRK09183 521098004258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098004259 Walker A motif; other site 521098004260 ATP binding site [chemical binding]; other site 521098004261 Walker B motif; other site 521098004262 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 521098004263 Transposase, Mutator family; Region: Transposase_mut; pfam00872 521098004264 MULE transposase domain; Region: MULE; pfam10551 521098004265 Transposase, Mutator family; Region: Transposase_mut; pfam00872 521098004266 MULE transposase domain; Region: MULE; pfam10551 521098004267 Ycf48-like protein; Provisional; Region: PRK13684 521098004268 VPS10 domain; Region: VPS10; smart00602 521098004269 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 521098004270 Transposase; Region: HTH_Tnp_1; pfam01527 521098004271 HTH-like domain; Region: HTH_21; pfam13276 521098004272 Integrase core domain; Region: rve; pfam00665 521098004273 Integrase core domain; Region: rve_3; pfam13683 521098004274 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 521098004275 Transposase, Mutator family; Region: Transposase_mut; pfam00872 521098004276 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 521098004277 MULE transposase domain; Region: MULE; pfam10551 521098004278 H+ Antiporter protein; Region: 2A0121; TIGR00900 521098004279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098004280 putative substrate translocation pore; other site 521098004281 YolD-like protein; Region: YolD; pfam08863 521098004282 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 521098004283 putative trimer interface [polypeptide binding]; other site 521098004284 putative CoA binding site [chemical binding]; other site 521098004285 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 521098004286 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 521098004287 putative trimer interface [polypeptide binding]; other site 521098004288 putative CoA binding site [chemical binding]; other site 521098004289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098004290 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 521098004291 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 521098004292 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 521098004293 active site 521098004294 Transposase, Mutator family; Region: Transposase_mut; pfam00872 521098004295 MULE transposase domain; Region: MULE; pfam10551 521098004296 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 521098004297 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521098004298 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521098004299 DNA binding residues [nucleotide binding] 521098004300 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 521098004301 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 521098004302 active site 521098004303 NTP binding site [chemical binding]; other site 521098004304 metal binding triad [ion binding]; metal-binding site 521098004305 Transposase, Mutator family; Region: Transposase_mut; pfam00872 521098004306 MULE transposase domain; Region: MULE; pfam10551 521098004307 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521098004308 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 521098004309 active site 521098004310 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 521098004311 Transposase, Mutator family; Region: Transposase_mut; pfam00872 521098004312 MULE transposase domain; Region: MULE; pfam10551 521098004313 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 521098004314 Part of AAA domain; Region: AAA_19; pfam13245 521098004315 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 521098004316 AAA domain; Region: AAA_12; pfam13087 521098004317 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 521098004318 putative active site [active] 521098004319 Transposase [DNA replication, recombination, and repair]; Region: COG5421 521098004320 Transposase [DNA replication, recombination, and repair]; Region: COG5421 521098004321 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 521098004322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 521098004323 DNA-binding interface [nucleotide binding]; DNA binding site 521098004324 Integrase core domain; Region: rve; pfam00665 521098004325 transposase/IS protein; Provisional; Region: PRK09183 521098004326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098004327 Walker A motif; other site 521098004328 ATP binding site [chemical binding]; other site 521098004329 Walker B motif; other site 521098004330 isocitrate dehydrogenase; Validated; Region: PRK09222 521098004331 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 521098004332 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 521098004333 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 521098004334 Spore germination protein; Region: Spore_permease; cl17796 521098004335 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 521098004336 UDP-glucose 4-epimerase; Region: PLN02240 521098004337 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 521098004338 NAD binding site [chemical binding]; other site 521098004339 homodimer interface [polypeptide binding]; other site 521098004340 active site 521098004341 substrate binding site [chemical binding]; other site 521098004342 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 521098004343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 521098004344 stage V sporulation protein K; Region: spore_V_K; TIGR02881 521098004345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098004346 Walker A motif; other site 521098004347 ATP binding site [chemical binding]; other site 521098004348 Walker B motif; other site 521098004349 arginine finger; other site 521098004350 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 521098004351 G1 box; other site 521098004352 GTP/Mg2+ binding site [chemical binding]; other site 521098004353 G2 box; other site 521098004354 Switch I region; other site 521098004355 G3 box; other site 521098004356 Switch II region; other site 521098004357 G4 box; other site 521098004358 G5 box; other site 521098004359 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 521098004360 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 521098004361 HflX GTPase family; Region: HflX; cd01878 521098004362 G1 box; other site 521098004363 GTP/Mg2+ binding site [chemical binding]; other site 521098004364 Switch I region; other site 521098004365 G2 box; other site 521098004366 G3 box; other site 521098004367 Switch II region; other site 521098004368 G4 box; other site 521098004369 G5 box; other site 521098004370 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 521098004371 Aluminium resistance protein; Region: Alum_res; pfam06838 521098004372 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 521098004373 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 521098004374 DNA binding residues [nucleotide binding] 521098004375 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 521098004376 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 521098004377 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 521098004378 Gamma subunit of transcription initiation factor IIA, N-terminal helical domain; Region: TFIIA_gamma_N; cl03508 521098004379 TFIIA subunit interface [polypeptide binding]; other site 521098004380 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521098004381 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521098004382 DNA binding site [nucleotide binding] 521098004383 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 521098004384 ligand binding site [chemical binding]; other site 521098004385 dimerization interface [polypeptide binding]; other site 521098004386 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 521098004387 galactarate dehydratase; Region: galactar-dH20; TIGR03248 521098004388 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 521098004389 KduI/IolB family; Region: KduI; pfam04962 521098004390 altronate oxidoreductase; Provisional; Region: PRK03643 521098004391 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 521098004392 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 521098004393 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 521098004394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098004395 putative substrate translocation pore; other site 521098004396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098004397 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 521098004398 LexA repressor; Validated; Region: PRK00215 521098004399 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 521098004400 Catalytic site [active] 521098004401 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 521098004402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521098004403 active site 521098004404 motif I; other site 521098004405 motif II; other site 521098004406 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 521098004407 glycyl-tRNA synthetase; Provisional; Region: PRK04173 521098004408 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 521098004409 motif 1; other site 521098004410 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 521098004411 active site 521098004412 motif 2; other site 521098004413 motif 3; other site 521098004414 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 521098004415 anticodon binding site; other site 521098004416 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 521098004417 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 521098004418 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 521098004419 FAD binding site [chemical binding]; other site 521098004420 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521098004421 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 521098004422 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 521098004423 metal binding site [ion binding]; metal-binding site 521098004424 active site 521098004425 I-site; other site 521098004426 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 521098004427 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 521098004428 putative dimer interface [polypeptide binding]; other site 521098004429 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 521098004430 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 521098004431 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 521098004432 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 521098004433 Ligand binding site [chemical binding]; other site 521098004434 Electron transfer flavoprotein domain; Region: ETF; pfam01012 521098004435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 521098004436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 521098004437 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 521098004438 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 521098004439 4Fe-4S binding domain; Region: Fer4; cl02805 521098004440 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 521098004441 Cysteine-rich domain; Region: CCG; pfam02754 521098004442 Cysteine-rich domain; Region: CCG; pfam02754 521098004443 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 521098004444 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 521098004445 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 521098004446 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 521098004447 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 521098004448 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 521098004449 substrate binding site [chemical binding]; other site 521098004450 oxyanion hole (OAH) forming residues; other site 521098004451 trimer interface [polypeptide binding]; other site 521098004452 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 521098004453 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 521098004454 dimer interface [polypeptide binding]; other site 521098004455 active site 521098004456 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 521098004457 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 521098004458 active site 521098004459 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 521098004460 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521098004461 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 521098004462 acyl-activating enzyme (AAE) consensus motif; other site 521098004463 putative AMP binding site [chemical binding]; other site 521098004464 putative active site [active] 521098004465 putative CoA binding site [chemical binding]; other site 521098004466 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 521098004467 CoenzymeA binding site [chemical binding]; other site 521098004468 subunit interaction site [polypeptide binding]; other site 521098004469 PHB binding site; other site 521098004470 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 521098004471 ATP cone domain; Region: ATP-cone; pfam03477 521098004472 Class I ribonucleotide reductase; Region: RNR_I; cd01679 521098004473 active site 521098004474 dimer interface [polypeptide binding]; other site 521098004475 catalytic residues [active] 521098004476 effector binding site; other site 521098004477 R2 peptide binding site; other site 521098004478 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 521098004479 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 521098004480 dimer interface [polypeptide binding]; other site 521098004481 putative radical transfer pathway; other site 521098004482 diiron center [ion binding]; other site 521098004483 tyrosyl radical; other site 521098004484 Amino acid permease; Region: AA_permease_2; pfam13520 521098004485 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 521098004486 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 521098004487 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 521098004488 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 521098004489 EamA-like transporter family; Region: EamA; pfam00892 521098004490 EamA-like transporter family; Region: EamA; pfam00892 521098004491 PEP synthetase regulatory protein; Provisional; Region: PRK05339 521098004492 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 521098004493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521098004494 DNA-binding site [nucleotide binding]; DNA binding site 521098004495 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 521098004496 FOG: CBS domain [General function prediction only]; Region: COG0517 521098004497 pyruvate phosphate dikinase; Provisional; Region: PRK09279 521098004498 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 521098004499 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 521098004500 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 521098004501 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 521098004502 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 521098004503 putative active site [active] 521098004504 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 521098004505 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 521098004506 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 521098004507 hypothetical protein; Provisional; Region: PRK09262 521098004508 hypothetical protein; Validated; Region: PRK06201 521098004509 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 521098004510 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521098004511 Transcriptional regulators [Transcription]; Region: FadR; COG2186 521098004512 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521098004513 DNA-binding site [nucleotide binding]; DNA binding site 521098004514 FCD domain; Region: FCD; pfam07729 521098004515 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 521098004516 tetramer interface [polypeptide binding]; other site 521098004517 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 521098004518 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 521098004519 tetramer interface [polypeptide binding]; other site 521098004520 active site 521098004521 metal binding site [ion binding]; metal-binding site 521098004522 Amidohydrolase; Region: Amidohydro_2; pfam04909 521098004523 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 521098004524 active site 1 [active] 521098004525 dimer interface [polypeptide binding]; other site 521098004526 hexamer interface [polypeptide binding]; other site 521098004527 active site 2 [active] 521098004528 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 521098004529 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 521098004530 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 521098004531 active site 521098004532 catalytic residues [active] 521098004533 metal binding site [ion binding]; metal-binding site 521098004534 DmpG-like communication domain; Region: DmpG_comm; pfam07836 521098004535 acetaldehyde dehydrogenase; Validated; Region: PRK08300 521098004536 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 521098004537 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 521098004538 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 521098004539 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 521098004540 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 521098004541 NAD binding site [chemical binding]; other site 521098004542 catalytic residues [active] 521098004543 Class III extradiol dioxygenases with similarity to homoprotocatechuate 2,3-dioxygenase, which catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD_like; cd07362 521098004544 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 521098004545 putative active site [active] 521098004546 putative metal binding site [ion binding]; other site 521098004547 Transcriptional regulator [Transcription]; Region: IclR; COG1414 521098004548 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521098004549 putative DNA binding site [nucleotide binding]; other site 521098004550 putative Zn2+ binding site [ion binding]; other site 521098004551 Bacterial transcriptional regulator; Region: IclR; pfam01614 521098004552 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 521098004553 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 521098004554 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 521098004555 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 521098004556 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 521098004557 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 521098004558 active site 521098004559 metal-binding site 521098004560 glutamine synthetase, type I; Region: GlnA; TIGR00653 521098004561 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 521098004562 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 521098004563 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 521098004564 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 521098004565 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 521098004566 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 521098004567 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 521098004568 dimer interface [polypeptide binding]; other site 521098004569 putative tRNA-binding site [nucleotide binding]; other site 521098004570 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 521098004571 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 521098004572 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521098004573 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521098004574 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521098004575 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 521098004576 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 521098004577 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 521098004578 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 521098004579 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 521098004580 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 521098004581 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 521098004582 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 521098004583 Dimer interface [polypeptide binding]; other site 521098004584 anticodon binding site; other site 521098004585 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 521098004586 homodimer interface [polypeptide binding]; other site 521098004587 motif 1; other site 521098004588 motif 2; other site 521098004589 active site 521098004590 motif 3; other site 521098004591 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 521098004592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098004593 Walker A motif; other site 521098004594 ATP binding site [chemical binding]; other site 521098004595 Walker B motif; other site 521098004596 arginine finger; other site 521098004597 Peptidase family M41; Region: Peptidase_M41; pfam01434 521098004598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 521098004599 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 521098004600 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 521098004601 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 521098004602 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 521098004603 active site 521098004604 putative substrate binding pocket [chemical binding]; other site 521098004605 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 521098004606 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 521098004607 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 521098004608 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 521098004609 nucleotide binding site [chemical binding]; other site 521098004610 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 521098004611 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 521098004612 active site 521098004613 DNA binding site [nucleotide binding] 521098004614 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 521098004615 DNA binding site [nucleotide binding] 521098004616 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 521098004617 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 521098004618 putative DNA binding site [nucleotide binding]; other site 521098004619 putative homodimer interface [polypeptide binding]; other site 521098004620 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 521098004621 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 521098004622 active site 521098004623 catalytic site [active] 521098004624 substrate binding site [chemical binding]; other site 521098004625 DEAD/DEAH box helicase; Region: DEAD; pfam00270 521098004626 ATP binding site [chemical binding]; other site 521098004627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 521098004628 putative Mg++ binding site [ion binding]; other site 521098004629 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 521098004630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521098004631 TPR motif; other site 521098004632 binding surface 521098004633 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521098004634 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 521098004635 putative DNA binding site [nucleotide binding]; other site 521098004636 putative Zn2+ binding site [ion binding]; other site 521098004637 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 521098004638 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 521098004639 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 521098004640 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 521098004641 active site 521098004642 NTP binding site [chemical binding]; other site 521098004643 metal binding triad [ion binding]; metal-binding site 521098004644 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 521098004645 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 521098004646 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 521098004647 dihydrodipicolinate reductase; Provisional; Region: PRK00048 521098004648 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 521098004649 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 521098004650 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 521098004651 homodimer interface [polypeptide binding]; other site 521098004652 metal binding site [ion binding]; metal-binding site 521098004653 Transposase domain (DUF772); Region: DUF772; pfam05598 521098004654 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 521098004655 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 521098004656 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 521098004657 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 521098004658 Bacitracin resistance protein BacA; Region: BacA; pfam02673 521098004659 Uncharacterized membrane protein [Function unknown]; Region: COG3949 521098004660 Uncharacterized conserved protein [Function unknown]; Region: COG1284 521098004661 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 521098004662 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 521098004663 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 521098004664 hypothetical protein; Provisional; Region: PRK03636 521098004665 UPF0302 domain; Region: UPF0302; pfam08864 521098004666 A short protein domain of unknown function; Region: IDEAL; smart00914 521098004667 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 521098004668 prephenate dehydrogenase; Validated; Region: PRK08507 521098004669 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 521098004670 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 521098004671 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 521098004672 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 521098004673 substrate binding site [chemical binding]; other site 521098004674 active site 521098004675 catalytic residues [active] 521098004676 heterodimer interface [polypeptide binding]; other site 521098004677 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 521098004678 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 521098004679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098004680 catalytic residue [active] 521098004681 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 521098004682 active site 521098004683 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 521098004684 active site 521098004685 ribulose/triose binding site [chemical binding]; other site 521098004686 phosphate binding site [ion binding]; other site 521098004687 substrate (anthranilate) binding pocket [chemical binding]; other site 521098004688 product (indole) binding pocket [chemical binding]; other site 521098004689 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 521098004690 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 521098004691 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 521098004692 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 521098004693 homotrimer interaction site [polypeptide binding]; other site 521098004694 active site 521098004695 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 521098004696 active site 521098004697 dimer interface [polypeptide binding]; other site 521098004698 metal binding site [ion binding]; metal-binding site 521098004699 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 521098004700 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 521098004701 Tetramer interface [polypeptide binding]; other site 521098004702 active site 521098004703 FMN-binding site [chemical binding]; other site 521098004704 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 521098004705 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 521098004706 oligomer interface [polypeptide binding]; other site 521098004707 active site 521098004708 metal binding site [ion binding]; metal-binding site 521098004709 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 521098004710 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 521098004711 oligomer interface [polypeptide binding]; other site 521098004712 active site 521098004713 metal binding site [ion binding]; metal-binding site 521098004714 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 521098004715 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 521098004716 oligomer interface [polypeptide binding]; other site 521098004717 active site 521098004718 metal binding site [ion binding]; metal-binding site 521098004719 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521098004720 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 521098004721 active site 521098004722 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521098004723 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521098004724 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 521098004725 N-acetyl-D-glucosamine binding site [chemical binding]; other site 521098004726 catalytic residue [active] 521098004727 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 521098004728 metal ion-dependent adhesion site (MIDAS); other site 521098004729 MoxR-like ATPases [General function prediction only]; Region: COG0714 521098004730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098004731 Walker A motif; other site 521098004732 ATP binding site [chemical binding]; other site 521098004733 Walker B motif; other site 521098004734 arginine finger; other site 521098004735 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 521098004736 E3 interaction surface; other site 521098004737 lipoyl attachment site [posttranslational modification]; other site 521098004738 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 521098004739 Transglycosylase; Region: Transgly; pfam00912 521098004740 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 521098004741 FOG: CBS domain [General function prediction only]; Region: COG0517 521098004742 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 521098004743 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 521098004744 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 521098004745 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 521098004746 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 521098004747 active site 521098004748 nucleophile elbow; other site 521098004749 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 521098004750 active site 521098004751 multimer interface [polypeptide binding]; other site 521098004752 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 521098004753 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 521098004754 substrate binding pocket [chemical binding]; other site 521098004755 chain length determination region; other site 521098004756 substrate-Mg2+ binding site; other site 521098004757 catalytic residues [active] 521098004758 aspartate-rich region 1; other site 521098004759 active site lid residues [active] 521098004760 aspartate-rich region 2; other site 521098004761 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 521098004762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098004763 S-adenosylmethionine binding site [chemical binding]; other site 521098004764 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 521098004765 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 521098004766 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 521098004767 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 521098004768 putative NAD(P) binding site [chemical binding]; other site 521098004769 catalytic Zn binding site [ion binding]; other site 521098004770 structural Zn binding site [ion binding]; other site 521098004771 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 521098004772 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 521098004773 G1 box; other site 521098004774 GTP/Mg2+ binding site [chemical binding]; other site 521098004775 G2 box; other site 521098004776 Switch I region; other site 521098004777 G3 box; other site 521098004778 Switch II region; other site 521098004779 G5 box; other site 521098004780 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 521098004781 lipoyl attachment site [posttranslational modification]; other site 521098004782 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 521098004783 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 521098004784 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 521098004785 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 521098004786 GTP-binding protein Der; Reviewed; Region: PRK00093 521098004787 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 521098004788 G1 box; other site 521098004789 GTP/Mg2+ binding site [chemical binding]; other site 521098004790 Switch I region; other site 521098004791 G2 box; other site 521098004792 Switch II region; other site 521098004793 G3 box; other site 521098004794 G4 box; other site 521098004795 G5 box; other site 521098004796 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 521098004797 G1 box; other site 521098004798 GTP/Mg2+ binding site [chemical binding]; other site 521098004799 Switch I region; other site 521098004800 G2 box; other site 521098004801 G3 box; other site 521098004802 Switch II region; other site 521098004803 G4 box; other site 521098004804 G5 box; other site 521098004805 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 521098004806 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 521098004807 RNA binding site [nucleotide binding]; other site 521098004808 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 521098004809 RNA binding site [nucleotide binding]; other site 521098004810 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 521098004811 RNA binding site [nucleotide binding]; other site 521098004812 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 521098004813 RNA binding site [nucleotide binding]; other site 521098004814 domain interface; other site 521098004815 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 521098004816 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 521098004817 putative acyl-acceptor binding pocket; other site 521098004818 cytidylate kinase; Provisional; Region: cmk; PRK00023 521098004819 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 521098004820 CMP-binding site; other site 521098004821 The sites determining sugar specificity; other site 521098004822 Flagellar protein YcgR; Region: YcgR_2; pfam12945 521098004823 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 521098004824 PilZ domain; Region: PilZ; pfam07238 521098004825 germination protein YpeB; Region: spore_YpeB; TIGR02889 521098004826 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 521098004827 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 521098004828 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 521098004829 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 521098004830 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 521098004831 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 521098004832 NAD(P) binding site [chemical binding]; other site 521098004833 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 521098004834 catabolite control protein A; Region: ccpA; TIGR01481 521098004835 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521098004836 DNA binding site [nucleotide binding] 521098004837 domain linker motif; other site 521098004838 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 521098004839 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 521098004840 Part of AAA domain; Region: AAA_19; pfam13245 521098004841 Family description; Region: UvrD_C_2; pfam13538 521098004842 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 521098004843 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 521098004844 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521098004845 putative active site [active] 521098004846 putative metal binding site [ion binding]; other site 521098004847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098004848 S-adenosylmethionine binding site [chemical binding]; other site 521098004849 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521098004850 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 521098004851 Protease prsW family; Region: PrsW-protease; pfam13367 521098004852 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 521098004853 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521098004854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098004855 non-specific DNA binding site [nucleotide binding]; other site 521098004856 salt bridge; other site 521098004857 sequence-specific DNA binding site [nucleotide binding]; other site 521098004858 tetrathionate reductase subunit A; Provisional; Region: PRK14991 521098004859 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 521098004860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 521098004861 dimerization interface [polypeptide binding]; other site 521098004862 PAS domain; Region: PAS; smart00091 521098004863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521098004864 dimer interface [polypeptide binding]; other site 521098004865 phosphorylation site [posttranslational modification] 521098004866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098004867 ATP binding site [chemical binding]; other site 521098004868 Mg2+ binding site [ion binding]; other site 521098004869 G-X-G motif; other site 521098004870 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521098004871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098004872 active site 521098004873 phosphorylation site [posttranslational modification] 521098004874 intermolecular recognition site; other site 521098004875 dimerization interface [polypeptide binding]; other site 521098004876 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521098004877 DNA binding site [nucleotide binding] 521098004878 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 521098004879 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 521098004880 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 521098004881 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521098004882 RNA binding surface [nucleotide binding]; other site 521098004883 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 521098004884 active site 521098004885 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 521098004886 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 521098004887 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 521098004888 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 521098004889 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 521098004890 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 521098004891 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 521098004892 Peptidase family M50; Region: Peptidase_M50; pfam02163 521098004893 active site 521098004894 putative substrate binding region [chemical binding]; other site 521098004895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 521098004896 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 521098004897 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 521098004898 stage V sporulation protein AD; Validated; Region: PRK08304 521098004899 stage V sporulation protein AD; Provisional; Region: PRK12404 521098004900 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 521098004901 sporulation sigma factor SigF; Validated; Region: PRK05572 521098004902 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521098004903 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 521098004904 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521098004905 DNA binding residues [nucleotide binding] 521098004906 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 521098004907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098004908 ATP binding site [chemical binding]; other site 521098004909 Mg2+ binding site [ion binding]; other site 521098004910 G-X-G motif; other site 521098004911 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521098004912 anti sigma factor interaction site; other site 521098004913 regulatory phosphorylation site [posttranslational modification]; other site 521098004914 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521098004915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098004916 non-specific DNA binding site [nucleotide binding]; other site 521098004917 salt bridge; other site 521098004918 sequence-specific DNA binding site [nucleotide binding]; other site 521098004919 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 521098004920 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 521098004921 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 521098004922 phosphopentomutase; Provisional; Region: PRK05362 521098004923 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 521098004924 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 521098004925 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 521098004926 active site 521098004927 Int/Topo IB signature motif; other site 521098004928 RNHCP domain; Region: RNHCP; pfam12647 521098004929 Integral membrane protein DUF95; Region: DUF95; cl00572 521098004930 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 521098004931 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 521098004932 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 521098004933 dimer interface [polypeptide binding]; other site 521098004934 ADP-ribose binding site [chemical binding]; other site 521098004935 active site 521098004936 nudix motif; other site 521098004937 metal binding site [ion binding]; metal-binding site 521098004938 peptidase T-like protein; Region: PepT-like; TIGR01883 521098004939 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 521098004940 metal binding site [ion binding]; metal-binding site 521098004941 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 521098004942 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 521098004943 lipoyl synthase; Provisional; Region: PRK05481 521098004944 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521098004945 FeS/SAM binding site; other site 521098004946 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 521098004947 trimer interface [polypeptide binding]; other site 521098004948 dimer interface [polypeptide binding]; other site 521098004949 putative active site [active] 521098004950 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 521098004951 MoaE interaction surface [polypeptide binding]; other site 521098004952 MoeB interaction surface [polypeptide binding]; other site 521098004953 thiocarboxylated glycine; other site 521098004954 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 521098004955 MoaE homodimer interface [polypeptide binding]; other site 521098004956 MoaD interaction [polypeptide binding]; other site 521098004957 active site residues [active] 521098004958 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 521098004959 active site 521098004960 Predicted permease; Region: DUF318; cl17795 521098004961 Protein of unknown function DUF45; Region: DUF45; pfam01863 521098004962 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 521098004963 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 521098004964 metal binding site [ion binding]; metal-binding site 521098004965 dimer interface [polypeptide binding]; other site 521098004966 putative heme peroxidase; Provisional; Region: PRK12276 521098004967 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 521098004968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098004969 active site 521098004970 phosphorylation site [posttranslational modification] 521098004971 intermolecular recognition site; other site 521098004972 dimerization interface [polypeptide binding]; other site 521098004973 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 521098004974 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 521098004975 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521098004976 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 521098004977 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 521098004978 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 521098004979 Walker A/P-loop; other site 521098004980 ATP binding site [chemical binding]; other site 521098004981 Q-loop/lid; other site 521098004982 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 521098004983 ABC transporter signature motif; other site 521098004984 Walker B; other site 521098004985 D-loop; other site 521098004986 H-loop/switch region; other site 521098004987 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 521098004988 ATP-NAD kinase; Region: NAD_kinase; pfam01513 521098004989 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 521098004990 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521098004991 RNA binding surface [nucleotide binding]; other site 521098004992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098004993 S-adenosylmethionine binding site [chemical binding]; other site 521098004994 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 521098004995 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 521098004996 substrate binding pocket [chemical binding]; other site 521098004997 chain length determination region; other site 521098004998 substrate-Mg2+ binding site; other site 521098004999 catalytic residues [active] 521098005000 aspartate-rich region 1; other site 521098005001 active site lid residues [active] 521098005002 aspartate-rich region 2; other site 521098005003 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 521098005004 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 521098005005 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 521098005006 generic binding surface II; other site 521098005007 generic binding surface I; other site 521098005008 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 521098005009 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 521098005010 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 521098005011 homodimer interface [polypeptide binding]; other site 521098005012 NADP binding site [chemical binding]; other site 521098005013 substrate binding site [chemical binding]; other site 521098005014 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 521098005015 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 521098005016 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521098005017 Glycoprotease family; Region: Peptidase_M22; pfam00814 521098005018 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 521098005019 putative RNA binding site [nucleotide binding]; other site 521098005020 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 521098005021 Asp23 family; Region: Asp23; cl00574 521098005022 Asp23 family; Region: Asp23; pfam03780 521098005023 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 521098005024 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 521098005025 ATP-grasp domain; Region: ATP-grasp_4; cl17255 521098005026 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 521098005027 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 521098005028 carboxyltransferase (CT) interaction site; other site 521098005029 biotinylation site [posttranslational modification]; other site 521098005030 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 521098005031 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 521098005032 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 521098005033 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 521098005034 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 521098005035 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 521098005036 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 521098005037 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 521098005038 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 521098005039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 521098005040 Walker A motif; other site 521098005041 ATP binding site [chemical binding]; other site 521098005042 Walker B motif; other site 521098005043 elongation factor P; Validated; Region: PRK00529 521098005044 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 521098005045 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 521098005046 RNA binding site [nucleotide binding]; other site 521098005047 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 521098005048 RNA binding site [nucleotide binding]; other site 521098005049 Dehydroquinase class II; Region: DHquinase_II; pfam01220 521098005050 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 521098005051 trimer interface [polypeptide binding]; other site 521098005052 active site 521098005053 dimer interface [polypeptide binding]; other site 521098005054 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521098005055 catalytic core [active] 521098005056 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 521098005057 tetramer interface [polypeptide binding]; other site 521098005058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098005059 catalytic residue [active] 521098005060 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 521098005061 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 521098005062 tetramer interface [polypeptide binding]; other site 521098005063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098005064 catalytic residue [active] 521098005065 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 521098005066 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 521098005067 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 521098005068 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 521098005069 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521098005070 ATP binding site [chemical binding]; other site 521098005071 putative Mg++ binding site [ion binding]; other site 521098005072 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521098005073 nucleotide binding region [chemical binding]; other site 521098005074 ATP-binding site [chemical binding]; other site 521098005075 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 521098005076 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 521098005077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098005078 Walker A motif; other site 521098005079 ATP binding site [chemical binding]; other site 521098005080 Walker B motif; other site 521098005081 shikimate kinase; Reviewed; Region: aroK; PRK00131 521098005082 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 521098005083 ADP binding site [chemical binding]; other site 521098005084 magnesium binding site [ion binding]; other site 521098005085 putative shikimate binding site; other site 521098005086 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 521098005087 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521098005088 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521098005089 Type II/IV secretion system protein; Region: T2SE; pfam00437 521098005090 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 521098005091 Walker A motif; other site 521098005092 ATP binding site [chemical binding]; other site 521098005093 Walker B motif; other site 521098005094 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 521098005095 GTPase CgtA; Reviewed; Region: obgE; PRK12297 521098005096 GTP1/OBG; Region: GTP1_OBG; pfam01018 521098005097 Obg GTPase; Region: Obg; cd01898 521098005098 G1 box; other site 521098005099 GTP/Mg2+ binding site [chemical binding]; other site 521098005100 Switch I region; other site 521098005101 G2 box; other site 521098005102 G3 box; other site 521098005103 Switch II region; other site 521098005104 G4 box; other site 521098005105 G5 box; other site 521098005106 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 521098005107 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 521098005108 Protein of unknown function (DUF464); Region: DUF464; pfam04327 521098005109 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 521098005110 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 521098005111 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 521098005112 Peptidase family M50; Region: Peptidase_M50; pfam02163 521098005113 active site 521098005114 putative substrate binding region [chemical binding]; other site 521098005115 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 521098005116 Peptidase family M23; Region: Peptidase_M23; pfam01551 521098005117 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 521098005118 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 521098005119 P-loop; other site 521098005120 ADP binding residues [chemical binding]; other site 521098005121 Switch I; other site 521098005122 Switch II; other site 521098005123 septum formation inhibitor; Reviewed; Region: minC; PRK00513 521098005124 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 521098005125 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 521098005126 rod shape-determining protein MreC; Provisional; Region: PRK13922 521098005127 rod shape-determining protein MreC; Region: MreC; pfam04085 521098005128 rod shape-determining protein MreB; Provisional; Region: PRK13927 521098005129 MreB and similar proteins; Region: MreB_like; cd10225 521098005130 nucleotide binding site [chemical binding]; other site 521098005131 Mg binding site [ion binding]; other site 521098005132 putative protofilament interaction site [polypeptide binding]; other site 521098005133 RodZ interaction site [polypeptide binding]; other site 521098005134 hypothetical protein; Reviewed; Region: PRK00024 521098005135 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 521098005136 helix-hairpin-helix signature motif; other site 521098005137 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 521098005138 MPN+ (JAMM) motif; other site 521098005139 Zinc-binding site [ion binding]; other site 521098005140 Phosphoesterase family; Region: Phosphoesterase; pfam04185 521098005141 Domain of unknown function (DUF348); Region: DUF348; pfam03990 521098005142 Domain of unknown function (DUF348); Region: DUF348; pfam03990 521098005143 G5 domain; Region: G5; pfam07501 521098005144 3D domain; Region: 3D; cl01439 521098005145 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 521098005146 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521098005147 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521098005148 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521098005149 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 521098005150 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521098005151 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 521098005152 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 521098005153 HIGH motif; other site 521098005154 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 521098005155 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 521098005156 active site 521098005157 KMSKS motif; other site 521098005158 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 521098005159 tRNA binding surface [nucleotide binding]; other site 521098005160 anticodon binding site; other site 521098005161 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 521098005162 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 521098005163 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 521098005164 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 521098005165 inhibitor-cofactor binding pocket; inhibition site 521098005166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098005167 catalytic residue [active] 521098005168 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 521098005169 dimer interface [polypeptide binding]; other site 521098005170 active site 521098005171 Schiff base residues; other site 521098005172 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 521098005173 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 521098005174 active site 521098005175 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 521098005176 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 521098005177 domain interfaces; other site 521098005178 active site 521098005179 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 521098005180 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 521098005181 tRNA; other site 521098005182 putative tRNA binding site [nucleotide binding]; other site 521098005183 putative NADP binding site [chemical binding]; other site 521098005184 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 521098005185 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 521098005186 G1 box; other site 521098005187 GTP/Mg2+ binding site [chemical binding]; other site 521098005188 Switch I region; other site 521098005189 G2 box; other site 521098005190 G3 box; other site 521098005191 Switch II region; other site 521098005192 G4 box; other site 521098005193 G5 box; other site 521098005194 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 521098005195 Found in ATP-dependent protease La (LON); Region: LON; smart00464 521098005196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098005197 Walker A motif; other site 521098005198 ATP binding site [chemical binding]; other site 521098005199 Walker B motif; other site 521098005200 arginine finger; other site 521098005201 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 521098005202 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 521098005203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098005204 Walker A motif; other site 521098005205 ATP binding site [chemical binding]; other site 521098005206 Walker B motif; other site 521098005207 arginine finger; other site 521098005208 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 521098005209 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 521098005210 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 521098005211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098005212 Walker A motif; other site 521098005213 ATP binding site [chemical binding]; other site 521098005214 Walker B motif; other site 521098005215 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 521098005216 Clp protease; Region: CLP_protease; pfam00574 521098005217 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 521098005218 oligomer interface [polypeptide binding]; other site 521098005219 active site residues [active] 521098005220 trigger factor; Provisional; Region: tig; PRK01490 521098005221 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 521098005222 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 521098005223 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 521098005224 active site 521098005225 dimerization interface [polypeptide binding]; other site 521098005226 glutamate racemase; Provisional; Region: PRK00865 521098005227 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 521098005228 MarR family; Region: MarR; pfam01047 521098005229 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 521098005230 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 521098005231 active site 521098005232 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 521098005233 CoA-transferase family III; Region: CoA_transf_3; pfam02515 521098005234 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 521098005235 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 521098005236 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 521098005237 DNA binding residues [nucleotide binding] 521098005238 dimerization interface [polypeptide binding]; other site 521098005239 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 521098005240 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521098005241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098005242 homodimer interface [polypeptide binding]; other site 521098005243 catalytic residue [active] 521098005244 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 521098005245 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 521098005246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521098005247 DNA-binding site [nucleotide binding]; DNA binding site 521098005248 UTRA domain; Region: UTRA; pfam07702 521098005249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098005250 putative substrate translocation pore; other site 521098005251 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521098005252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098005253 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 521098005254 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 521098005255 active site residue [active] 521098005256 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 521098005257 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 521098005258 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 521098005259 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 521098005260 L-aspartate oxidase; Provisional; Region: PRK06175 521098005261 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 521098005262 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 521098005263 putative Iron-sulfur protein interface [polypeptide binding]; other site 521098005264 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 521098005265 proximal heme binding site [chemical binding]; other site 521098005266 distal heme binding site [chemical binding]; other site 521098005267 putative dimer interface [polypeptide binding]; other site 521098005268 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 521098005269 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 521098005270 GIY-YIG motif/motif A; other site 521098005271 active site 521098005272 catalytic site [active] 521098005273 putative DNA binding site [nucleotide binding]; other site 521098005274 metal binding site [ion binding]; metal-binding site 521098005275 UvrB/uvrC motif; Region: UVR; pfam02151 521098005276 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 521098005277 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 521098005278 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 521098005279 HIGH motif; other site 521098005280 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 521098005281 active site 521098005282 KMSKS motif; other site 521098005283 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 521098005284 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521098005285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098005286 homodimer interface [polypeptide binding]; other site 521098005287 catalytic residue [active] 521098005288 Protein of unknown function (DUF502); Region: DUF502; cl01107 521098005289 calcium/proton exchanger (cax); Region: cax; TIGR00378 521098005290 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 521098005291 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 521098005292 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 521098005293 Protein of unknown function DUF72; Region: DUF72; pfam01904 521098005294 Transcriptional regulator [Transcription]; Region: LytR; COG1316 521098005295 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 521098005296 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 521098005297 Ligand binding site; other site 521098005298 Putative Catalytic site; other site 521098005299 DXD motif; other site 521098005300 Predicted membrane protein [Function unknown]; Region: COG2246 521098005301 GtrA-like protein; Region: GtrA; pfam04138 521098005302 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 521098005303 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 521098005304 Transcriptional regulators [Transcription]; Region: MarR; COG1846 521098005305 MarR family; Region: MarR_2; pfam12802 521098005306 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 521098005307 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 521098005308 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521098005309 active site 521098005310 dimer interface [polypeptide binding]; other site 521098005311 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 521098005312 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 521098005313 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 521098005314 putative active site [active] 521098005315 catalytic site [active] 521098005316 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 521098005317 putative active site [active] 521098005318 catalytic site [active] 521098005319 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 521098005320 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 521098005321 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 521098005322 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 521098005323 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 521098005324 effector binding site; other site 521098005325 dimer interface [polypeptide binding]; other site 521098005326 active site 521098005327 TSCPD domain; Region: TSCPD; pfam12637 521098005328 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 521098005329 ATP cone domain; Region: ATP-cone; pfam03477 521098005330 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 521098005331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521098005332 active site 521098005333 motif I; other site 521098005334 motif II; other site 521098005335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521098005336 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 521098005337 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 521098005338 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 521098005339 Ligand binding site; other site 521098005340 Putative Catalytic site; other site 521098005341 DXD motif; other site 521098005342 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 521098005343 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 521098005344 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 521098005345 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 521098005346 beta-galactosidase; Region: BGL; TIGR03356 521098005347 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 521098005348 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 521098005349 Walker A/P-loop; other site 521098005350 ATP binding site [chemical binding]; other site 521098005351 Q-loop/lid; other site 521098005352 ABC transporter signature motif; other site 521098005353 Walker B; other site 521098005354 D-loop; other site 521098005355 H-loop/switch region; other site 521098005356 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 521098005357 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 521098005358 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 521098005359 Walker A/P-loop; other site 521098005360 ATP binding site [chemical binding]; other site 521098005361 Q-loop/lid; other site 521098005362 ABC transporter signature motif; other site 521098005363 Walker B; other site 521098005364 D-loop; other site 521098005365 H-loop/switch region; other site 521098005366 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 521098005367 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 521098005368 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 521098005369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098005370 dimer interface [polypeptide binding]; other site 521098005371 conserved gate region; other site 521098005372 putative PBP binding loops; other site 521098005373 ABC-ATPase subunit interface; other site 521098005374 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 521098005375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098005376 dimer interface [polypeptide binding]; other site 521098005377 conserved gate region; other site 521098005378 putative PBP binding loops; other site 521098005379 ABC-ATPase subunit interface; other site 521098005380 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 521098005381 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 521098005382 substrate binding site [chemical binding]; other site 521098005383 Ferredoxin [Energy production and conversion]; Region: COG1146 521098005384 4Fe-4S binding domain; Region: Fer4; pfam00037 521098005385 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098005386 salt bridge; other site 521098005387 non-specific DNA binding site [nucleotide binding]; other site 521098005388 sequence-specific DNA binding site [nucleotide binding]; other site 521098005389 Transposase, Mutator family; Region: Transposase_mut; pfam00872 521098005390 MULE transposase domain; Region: MULE; pfam10551 521098005391 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 521098005392 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 521098005393 Walker A/P-loop; other site 521098005394 ATP binding site [chemical binding]; other site 521098005395 Q-loop/lid; other site 521098005396 ABC transporter signature motif; other site 521098005397 Walker B; other site 521098005398 D-loop; other site 521098005399 H-loop/switch region; other site 521098005400 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 521098005401 PhoU domain; Region: PhoU; pfam01895 521098005402 PhoU domain; Region: PhoU; pfam01895 521098005403 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521098005404 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521098005405 NlpC/P60 family; Region: NLPC_P60; pfam00877 521098005406 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 521098005407 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 521098005408 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 521098005409 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 521098005410 potential frameshift: common BLAST hit: gi|134298511|ref|YP_001112007.1| polysaccharide deacetylase 521098005411 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 521098005412 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 521098005413 NodB motif; other site 521098005414 putative active site [active] 521098005415 putative catalytic site [active] 521098005416 putative Zn binding site [ion binding]; other site 521098005417 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 521098005418 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 521098005419 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521098005420 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 521098005421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098005422 dimer interface [polypeptide binding]; other site 521098005423 conserved gate region; other site 521098005424 ABC-ATPase subunit interface; other site 521098005425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098005426 dimer interface [polypeptide binding]; other site 521098005427 conserved gate region; other site 521098005428 putative PBP binding loops; other site 521098005429 ABC-ATPase subunit interface; other site 521098005430 PBP superfamily domain; Region: PBP_like_2; cl17296 521098005431 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 521098005432 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 521098005433 TAP-like protein; Region: Abhydrolase_4; pfam08386 521098005434 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 521098005435 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 521098005436 dimer interface [polypeptide binding]; other site 521098005437 tetramer interface [polypeptide binding]; other site 521098005438 PYR/PP interface [polypeptide binding]; other site 521098005439 TPP binding site [chemical binding]; other site 521098005440 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 521098005441 TPP-binding site; other site 521098005442 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 521098005443 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 521098005444 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 521098005445 acyl-activating enzyme (AAE) consensus motif; other site 521098005446 putative AMP binding site [chemical binding]; other site 521098005447 putative active site [active] 521098005448 putative CoA binding site [chemical binding]; other site 521098005449 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 521098005450 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 521098005451 substrate binding site [chemical binding]; other site 521098005452 oxyanion hole (OAH) forming residues; other site 521098005453 trimer interface [polypeptide binding]; other site 521098005454 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 521098005455 UbiA prenyltransferase family; Region: UbiA; pfam01040 521098005456 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 521098005457 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 521098005458 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 521098005459 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 521098005460 catalytic loop [active] 521098005461 iron binding site [ion binding]; other site 521098005462 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 521098005463 4Fe-4S binding domain; Region: Fer4; pfam00037 521098005464 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 521098005465 [4Fe-4S] binding site [ion binding]; other site 521098005466 molybdopterin cofactor binding site; other site 521098005467 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 521098005468 molybdopterin cofactor binding site; other site 521098005469 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 521098005470 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 521098005471 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 521098005472 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521098005473 Coenzyme A binding pocket [chemical binding]; other site 521098005474 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 521098005475 EamA-like transporter family; Region: EamA; pfam00892 521098005476 Uncharacterized conserved protein [Function unknown]; Region: COG0327 521098005477 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 521098005478 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 521098005479 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 521098005480 dimer interface [polypeptide binding]; other site 521098005481 substrate binding site [chemical binding]; other site 521098005482 ATP binding site [chemical binding]; other site 521098005483 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 521098005484 substrate binding site [chemical binding]; other site 521098005485 multimerization interface [polypeptide binding]; other site 521098005486 ATP binding site [chemical binding]; other site 521098005487 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 521098005488 thiamine phosphate binding site [chemical binding]; other site 521098005489 active site 521098005490 pyrophosphate binding site [ion binding]; other site 521098005491 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 521098005492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521098005493 Walker A/P-loop; other site 521098005494 ATP binding site [chemical binding]; other site 521098005495 Q-loop/lid; other site 521098005496 ABC transporter signature motif; other site 521098005497 Walker B; other site 521098005498 D-loop; other site 521098005499 H-loop/switch region; other site 521098005500 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 521098005501 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521098005502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521098005503 Walker A/P-loop; other site 521098005504 ATP binding site [chemical binding]; other site 521098005505 Q-loop/lid; other site 521098005506 ABC transporter signature motif; other site 521098005507 Walker B; other site 521098005508 D-loop; other site 521098005509 H-loop/switch region; other site 521098005510 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 521098005511 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 521098005512 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 521098005513 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 521098005514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098005515 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521098005516 putative substrate translocation pore; other site 521098005517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098005518 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 521098005519 MarR family; Region: MarR; pfam01047 521098005520 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 521098005521 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 521098005522 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 521098005523 Walker A/P-loop; other site 521098005524 ATP binding site [chemical binding]; other site 521098005525 Q-loop/lid; other site 521098005526 ABC transporter signature motif; other site 521098005527 Walker B; other site 521098005528 D-loop; other site 521098005529 H-loop/switch region; other site 521098005530 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 521098005531 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 521098005532 ABC-ATPase subunit interface; other site 521098005533 dimer interface [polypeptide binding]; other site 521098005534 putative PBP binding regions; other site 521098005535 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 521098005536 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 521098005537 intersubunit interface [polypeptide binding]; other site 521098005538 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 521098005539 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 521098005540 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 521098005541 active site pocket [active] 521098005542 putative dimer interface [polypeptide binding]; other site 521098005543 putative cataytic base [active] 521098005544 Predicted transcriptional regulators [Transcription]; Region: COG1733 521098005545 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521098005546 dimerization interface [polypeptide binding]; other site 521098005547 putative DNA binding site [nucleotide binding]; other site 521098005548 putative Zn2+ binding site [ion binding]; other site 521098005549 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 521098005550 active site 521098005551 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 521098005552 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521098005553 FeS/SAM binding site; other site 521098005554 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 521098005555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521098005556 motif II; other site 521098005557 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 521098005558 exopolyphosphatase; Region: exo_poly_only; TIGR03706 521098005559 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 521098005560 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 521098005561 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 521098005562 homoserine O-succinyltransferase; Provisional; Region: PRK05368 521098005563 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 521098005564 proposed active site lysine [active] 521098005565 conserved cys residue [active] 521098005566 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 521098005567 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 521098005568 tetramerization interface [polypeptide binding]; other site 521098005569 active site 521098005570 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 521098005571 active site 521098005572 catalytic triad [active] 521098005573 oxyanion hole [active] 521098005574 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 521098005575 metal-binding site [ion binding] 521098005576 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 521098005577 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 521098005578 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 521098005579 Spore germination protein; Region: Spore_permease; cl17796 521098005580 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 521098005581 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 521098005582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521098005583 dimer interface [polypeptide binding]; other site 521098005584 phosphorylation site [posttranslational modification] 521098005585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098005586 ATP binding site [chemical binding]; other site 521098005587 Mg2+ binding site [ion binding]; other site 521098005588 G-X-G motif; other site 521098005589 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 521098005590 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 521098005591 active site 521098005592 FMN binding site [chemical binding]; other site 521098005593 substrate binding site [chemical binding]; other site 521098005594 homotetramer interface [polypeptide binding]; other site 521098005595 catalytic residue [active] 521098005596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521098005597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521098005598 dimer interface [polypeptide binding]; other site 521098005599 phosphorylation site [posttranslational modification] 521098005600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098005601 ATP binding site [chemical binding]; other site 521098005602 Mg2+ binding site [ion binding]; other site 521098005603 G-X-G motif; other site 521098005604 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521098005605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098005606 active site 521098005607 phosphorylation site [posttranslational modification] 521098005608 intermolecular recognition site; other site 521098005609 dimerization interface [polypeptide binding]; other site 521098005610 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521098005611 DNA binding site [nucleotide binding] 521098005612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521098005613 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 521098005614 Coenzyme A binding pocket [chemical binding]; other site 521098005615 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 521098005616 active site 521098005617 metal binding site [ion binding]; metal-binding site 521098005618 Uncharacterized conserved protein [Function unknown]; Region: COG0327 521098005619 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 521098005620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 521098005621 Uncharacterized conserved protein [Function unknown]; Region: COG0327 521098005622 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 521098005623 Family of unknown function (DUF633); Region: DUF633; pfam04816 521098005624 Uncharacterized conserved protein [Function unknown]; Region: COG1434 521098005625 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 521098005626 putative active site [active] 521098005627 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 521098005628 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 521098005629 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 521098005630 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521098005631 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 521098005632 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521098005633 DNA binding residues [nucleotide binding] 521098005634 DNA primase; Validated; Region: dnaG; PRK05667 521098005635 CHC2 zinc finger; Region: zf-CHC2; pfam01807 521098005636 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 521098005637 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 521098005638 active site 521098005639 metal binding site [ion binding]; metal-binding site 521098005640 interdomain interaction site; other site 521098005641 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 521098005642 Recombination protein O N terminal; Region: RecO_N; pfam11967 521098005643 DNA repair protein RecO; Region: reco; TIGR00613 521098005644 Recombination protein O C terminal; Region: RecO_C; pfam02565 521098005645 YqzL-like protein; Region: YqzL; pfam14006 521098005646 GTPase Era; Reviewed; Region: era; PRK00089 521098005647 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 521098005648 G1 box; other site 521098005649 GTP/Mg2+ binding site [chemical binding]; other site 521098005650 Switch I region; other site 521098005651 G2 box; other site 521098005652 Switch II region; other site 521098005653 G3 box; other site 521098005654 G4 box; other site 521098005655 G5 box; other site 521098005656 KH domain; Region: KH_2; pfam07650 521098005657 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 521098005658 metal-binding heat shock protein; Provisional; Region: PRK00016 521098005659 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 521098005660 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 521098005661 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521098005662 Zn2+ binding site [ion binding]; other site 521098005663 Mg2+ binding site [ion binding]; other site 521098005664 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 521098005665 PhoH-like protein; Region: PhoH; pfam02562 521098005666 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 521098005667 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 521098005668 YabP family; Region: YabP; cl06766 521098005669 Yqey-like protein; Region: YqeY; pfam09424 521098005670 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 521098005671 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 521098005672 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 521098005673 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 521098005674 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 521098005675 active site 521098005676 Ap6A binding site [chemical binding]; other site 521098005677 nudix motif; other site 521098005678 metal binding site [ion binding]; metal-binding site 521098005679 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 521098005680 intersubunit interface [polypeptide binding]; other site 521098005681 active site 521098005682 catalytic residue [active] 521098005683 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 521098005684 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 521098005685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521098005686 FeS/SAM binding site; other site 521098005687 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 521098005688 RNA methyltransferase, RsmE family; Region: TIGR00046 521098005689 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 521098005690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098005691 S-adenosylmethionine binding site [chemical binding]; other site 521098005692 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 521098005693 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521098005694 HSP70 interaction site [polypeptide binding]; other site 521098005695 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 521098005696 substrate binding site [polypeptide binding]; other site 521098005697 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 521098005698 Zn binding sites [ion binding]; other site 521098005699 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 521098005700 dimer interface [polypeptide binding]; other site 521098005701 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 521098005702 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 521098005703 nucleotide binding site [chemical binding]; other site 521098005704 NEF interaction site [polypeptide binding]; other site 521098005705 SBD interface [polypeptide binding]; other site 521098005706 GrpE; Region: GrpE; pfam01025 521098005707 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 521098005708 dimer interface [polypeptide binding]; other site 521098005709 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 521098005710 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 521098005711 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 521098005712 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 521098005713 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521098005714 FeS/SAM binding site; other site 521098005715 HemN C-terminal domain; Region: HemN_C; pfam06969 521098005716 GTP-binding protein LepA; Provisional; Region: PRK05433 521098005717 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 521098005718 G1 box; other site 521098005719 putative GEF interaction site [polypeptide binding]; other site 521098005720 GTP/Mg2+ binding site [chemical binding]; other site 521098005721 Switch I region; other site 521098005722 G2 box; other site 521098005723 G3 box; other site 521098005724 Switch II region; other site 521098005725 G4 box; other site 521098005726 G5 box; other site 521098005727 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 521098005728 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 521098005729 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 521098005730 Cation efflux family; Region: Cation_efflux; cl00316 521098005731 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 521098005732 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 521098005733 N-acetyl-D-glucosamine binding site [chemical binding]; other site 521098005734 catalytic residue [active] 521098005735 germination protease; Provisional; Region: PRK12362 521098005736 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 521098005737 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 521098005738 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 521098005739 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 521098005740 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 521098005741 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521098005742 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 521098005743 Competence protein; Region: Competence; pfam03772 521098005744 SLBB domain; Region: SLBB; pfam10531 521098005745 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 521098005746 Helix-hairpin-helix motif; Region: HHH; pfam00633 521098005747 manganese transport transcriptional regulator; Provisional; Region: PRK03902 521098005748 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 521098005749 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 521098005750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098005751 S-adenosylmethionine binding site [chemical binding]; other site 521098005752 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 521098005753 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521098005754 Zn2+ binding site [ion binding]; other site 521098005755 Mg2+ binding site [ion binding]; other site 521098005756 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 521098005757 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 521098005758 active site 521098005759 (T/H)XGH motif; other site 521098005760 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 521098005761 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 521098005762 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 521098005763 shikimate binding site; other site 521098005764 NAD(P) binding site [chemical binding]; other site 521098005765 ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597 521098005766 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 521098005767 GTP/Mg2+ binding site [chemical binding]; other site 521098005768 G4 box; other site 521098005769 G5 box; other site 521098005770 G1 box; other site 521098005771 Switch I region; other site 521098005772 G2 box; other site 521098005773 G3 box; other site 521098005774 Switch II region; other site 521098005775 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 521098005776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521098005777 active site 521098005778 motif I; other site 521098005779 motif II; other site 521098005780 sporulation sigma factor SigK; Reviewed; Region: PRK05803 521098005781 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521098005782 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521098005783 DNA binding residues [nucleotide binding] 521098005784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098005785 S-adenosylmethionine binding site [chemical binding]; other site 521098005786 YceG-like family; Region: YceG; pfam02618 521098005787 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 521098005788 dimerization interface [polypeptide binding]; other site 521098005789 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 521098005790 hypothetical protein; Provisional; Region: PRK05473 521098005791 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 521098005792 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 521098005793 motif 1; other site 521098005794 active site 521098005795 motif 2; other site 521098005796 motif 3; other site 521098005797 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 521098005798 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 521098005799 Domain of unknown function DUF20; Region: UPF0118; pfam01594 521098005800 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 521098005801 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 521098005802 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521098005803 catalytic residue [active] 521098005804 Predicted transcriptional regulator [Transcription]; Region: COG1959 521098005805 Transcriptional regulator; Region: Rrf2; pfam02082 521098005806 recombination factor protein RarA; Reviewed; Region: PRK13342 521098005807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098005808 Walker A motif; other site 521098005809 ATP binding site [chemical binding]; other site 521098005810 Walker B motif; other site 521098005811 arginine finger; other site 521098005812 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 521098005813 Low molecular weight phosphatase family; Region: LMWPc; cd00115 521098005814 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 521098005815 active site 521098005816 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 521098005817 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 521098005818 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521098005819 acyl-activating enzyme (AAE) consensus motif; other site 521098005820 AMP binding site [chemical binding]; other site 521098005821 active site 521098005822 CoA binding site [chemical binding]; other site 521098005823 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 521098005824 dimer interface [polypeptide binding]; other site 521098005825 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 521098005826 anticodon binding site; other site 521098005827 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 521098005828 homodimer interface [polypeptide binding]; other site 521098005829 motif 1; other site 521098005830 active site 521098005831 motif 2; other site 521098005832 GAD domain; Region: GAD; pfam02938 521098005833 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 521098005834 motif 3; other site 521098005835 histidyl-tRNA synthetase; Region: hisS; TIGR00442 521098005836 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 521098005837 dimer interface [polypeptide binding]; other site 521098005838 motif 1; other site 521098005839 active site 521098005840 motif 2; other site 521098005841 motif 3; other site 521098005842 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 521098005843 anticodon binding site; other site 521098005844 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 521098005845 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 521098005846 inhibitor-cofactor binding pocket; inhibition site 521098005847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098005848 catalytic residue [active] 521098005849 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 521098005850 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 521098005851 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 521098005852 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 521098005853 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 521098005854 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 521098005855 Walker A/P-loop; other site 521098005856 ATP binding site [chemical binding]; other site 521098005857 Q-loop/lid; other site 521098005858 ABC transporter signature motif; other site 521098005859 Walker B; other site 521098005860 D-loop; other site 521098005861 H-loop/switch region; other site 521098005862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098005863 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 521098005864 putative substrate translocation pore; other site 521098005865 conserved hypothetical protein; Region: MG423; TIGR00649 521098005866 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 521098005867 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 521098005868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098005869 dimer interface [polypeptide binding]; other site 521098005870 conserved gate region; other site 521098005871 putative PBP binding loops; other site 521098005872 ABC-ATPase subunit interface; other site 521098005873 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 521098005874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098005875 dimer interface [polypeptide binding]; other site 521098005876 conserved gate region; other site 521098005877 putative PBP binding loops; other site 521098005878 ABC-ATPase subunit interface; other site 521098005879 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 521098005880 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 521098005881 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 521098005882 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 521098005883 iron-sulfur cluster [ion binding]; other site 521098005884 [2Fe-2S] cluster binding site [ion binding]; other site 521098005885 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 521098005886 hydrophobic ligand binding site; other site 521098005887 enoyl-CoA hydratase; Provisional; Region: PRK07657 521098005888 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 521098005889 substrate binding site [chemical binding]; other site 521098005890 oxyanion hole (OAH) forming residues; other site 521098005891 trimer interface [polypeptide binding]; other site 521098005892 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 521098005893 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 521098005894 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 521098005895 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 521098005896 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 521098005897 active site 521098005898 catalytic residues [active] 521098005899 metal binding site [ion binding]; metal-binding site 521098005900 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 521098005901 carboxyltransferase (CT) interaction site; other site 521098005902 biotinylation site [posttranslational modification]; other site 521098005903 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 521098005904 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 521098005905 FAD binding site [chemical binding]; other site 521098005906 homotetramer interface [polypeptide binding]; other site 521098005907 substrate binding pocket [chemical binding]; other site 521098005908 catalytic base [active] 521098005909 putative acyltransferase; Provisional; Region: PRK05790 521098005910 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 521098005911 dimer interface [polypeptide binding]; other site 521098005912 active site 521098005913 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 521098005914 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 521098005915 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 521098005916 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 521098005917 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 521098005918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098005919 S-adenosylmethionine binding site [chemical binding]; other site 521098005920 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 521098005921 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 521098005922 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 521098005923 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 521098005924 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 521098005925 classical (c) SDRs; Region: SDR_c; cd05233 521098005926 NAD(P) binding site [chemical binding]; other site 521098005927 active site 521098005928 MFS/sugar transport protein; Region: MFS_2; pfam13347 521098005929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098005930 putative substrate translocation pore; other site 521098005931 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 521098005932 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521098005933 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521098005934 active site 521098005935 catalytic tetrad [active] 521098005936 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 521098005937 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 521098005938 dimer interface [polypeptide binding]; other site 521098005939 putative functional site; other site 521098005940 putative MPT binding site; other site 521098005941 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 521098005942 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 521098005943 active site 521098005944 tetramer interface; other site 521098005945 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 521098005946 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521098005947 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 521098005948 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521098005949 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 521098005950 NlpC/P60 family; Region: NLPC_P60; pfam00877 521098005951 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 521098005952 Part of AAA domain; Region: AAA_19; pfam13245 521098005953 Family description; Region: UvrD_C_2; pfam13538 521098005954 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 521098005955 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 521098005956 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 521098005957 benzoate transport; Region: 2A0115; TIGR00895 521098005958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098005959 putative substrate translocation pore; other site 521098005960 Predicted amidohydrolase [General function prediction only]; Region: COG0388 521098005961 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 521098005962 putative active site [active] 521098005963 catalytic triad [active] 521098005964 putative dimer interface [polypeptide binding]; other site 521098005965 amino acid transporter; Region: 2A0306; TIGR00909 521098005966 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 521098005967 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 521098005968 inhibitor-cofactor binding pocket; inhibition site 521098005969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098005970 catalytic residue [active] 521098005971 PAS domain; Region: PAS_9; pfam13426 521098005972 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521098005973 putative active site [active] 521098005974 heme pocket [chemical binding]; other site 521098005975 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 521098005976 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098005977 Walker A motif; other site 521098005978 ATP binding site [chemical binding]; other site 521098005979 Walker B motif; other site 521098005980 arginine finger; other site 521098005981 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 521098005982 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 521098005983 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 521098005984 FMN binding site [chemical binding]; other site 521098005985 active site 521098005986 catalytic residues [active] 521098005987 substrate binding site [chemical binding]; other site 521098005988 TM2 domain; Region: TM2; cl00984 521098005989 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 521098005990 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 521098005991 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 521098005992 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 521098005993 DNA binding site [nucleotide binding] 521098005994 sequence specific DNA binding site [nucleotide binding]; other site 521098005995 putative cAMP binding site [chemical binding]; other site 521098005996 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 521098005997 FeoA domain; Region: FeoA; pfam04023 521098005998 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 521098005999 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 521098006000 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 521098006001 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 521098006002 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 521098006003 substrate binding site [chemical binding]; other site 521098006004 active site 521098006005 ferrochelatase; Provisional; Region: PRK12435 521098006006 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 521098006007 C-terminal domain interface [polypeptide binding]; other site 521098006008 active site 521098006009 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 521098006010 active site 521098006011 N-terminal domain interface [polypeptide binding]; other site 521098006012 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 521098006013 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521098006014 Ycf48-like protein; Provisional; Region: PRK13684 521098006015 hypothetical protein; Provisional; Region: PRK10621 521098006016 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 521098006017 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 521098006018 metal binding site [ion binding]; metal-binding site 521098006019 active site 521098006020 I-site; other site 521098006021 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 521098006022 GAF domain; Region: GAF; pfam01590 521098006023 GAF domain; Region: GAF_2; pfam13185 521098006024 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 521098006025 putative active site [active] 521098006026 dimerization interface [polypeptide binding]; other site 521098006027 putative tRNAtyr binding site [nucleotide binding]; other site 521098006028 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 521098006029 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521098006030 Zn2+ binding site [ion binding]; other site 521098006031 Mg2+ binding site [ion binding]; other site 521098006032 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 521098006033 synthetase active site [active] 521098006034 NTP binding site [chemical binding]; other site 521098006035 metal binding site [ion binding]; metal-binding site 521098006036 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 521098006037 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 521098006038 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521098006039 active site 521098006040 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 521098006041 DHH family; Region: DHH; pfam01368 521098006042 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 521098006043 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 521098006044 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 521098006045 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 521098006046 Protein export membrane protein; Region: SecD_SecF; pfam02355 521098006047 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 521098006048 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 521098006049 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 521098006050 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 521098006051 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 521098006052 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 521098006053 GAF domain; Region: GAF; pfam01590 521098006054 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 521098006055 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 521098006056 metal binding site [ion binding]; metal-binding site 521098006057 active site 521098006058 I-site; other site 521098006059 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 521098006060 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 521098006061 metal binding site [ion binding]; metal-binding site 521098006062 active site 521098006063 I-site; other site 521098006064 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 521098006065 Preprotein translocase subunit; Region: YajC; pfam02699 521098006066 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 521098006067 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 521098006068 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 521098006069 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 521098006070 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 521098006071 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 521098006072 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521098006073 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 521098006074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098006075 Walker A motif; other site 521098006076 ATP binding site [chemical binding]; other site 521098006077 Walker B motif; other site 521098006078 arginine finger; other site 521098006079 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 521098006080 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 521098006081 RuvA N terminal domain; Region: RuvA_N; pfam01330 521098006082 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 521098006083 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 521098006084 active site 521098006085 putative DNA-binding cleft [nucleotide binding]; other site 521098006086 dimer interface [polypeptide binding]; other site 521098006087 hypothetical protein; Validated; Region: PRK00110 521098006088 NAD synthetase; Provisional; Region: PRK13980 521098006089 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 521098006090 homodimer interface [polypeptide binding]; other site 521098006091 NAD binding pocket [chemical binding]; other site 521098006092 ATP binding pocket [chemical binding]; other site 521098006093 Mg binding site [ion binding]; other site 521098006094 active-site loop [active] 521098006095 Predicted amidohydrolase [General function prediction only]; Region: COG0388 521098006096 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 521098006097 putative active site [active] 521098006098 catalytic triad [active] 521098006099 putative dimer interface [polypeptide binding]; other site 521098006100 Phosphotransferase enzyme family; Region: APH; pfam01636 521098006101 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 521098006102 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521098006103 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521098006104 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 521098006105 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 521098006106 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 521098006107 active site 521098006108 HIGH motif; other site 521098006109 dimer interface [polypeptide binding]; other site 521098006110 KMSKS motif; other site 521098006111 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521098006112 RNA binding surface [nucleotide binding]; other site 521098006113 Transglycosylase; Region: Transgly; pfam00912 521098006114 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 521098006115 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 521098006116 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 521098006117 MutS domain III; Region: MutS_III; cl17822 521098006118 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 521098006119 Walker A/P-loop; other site 521098006120 ATP binding site [chemical binding]; other site 521098006121 Q-loop/lid; other site 521098006122 ABC transporter signature motif; other site 521098006123 Walker B; other site 521098006124 D-loop; other site 521098006125 H-loop/switch region; other site 521098006126 Smr domain; Region: Smr; pfam01713 521098006127 Membrane protein of unknown function; Region: DUF360; pfam04020 521098006128 Colicin V production protein; Region: Colicin_V; pfam02674 521098006129 Cell division protein ZapA; Region: ZapA; pfam05164 521098006130 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 521098006131 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 521098006132 putative tRNA-binding site [nucleotide binding]; other site 521098006133 B3/4 domain; Region: B3_4; pfam03483 521098006134 tRNA synthetase B5 domain; Region: B5; smart00874 521098006135 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 521098006136 dimer interface [polypeptide binding]; other site 521098006137 motif 1; other site 521098006138 motif 3; other site 521098006139 motif 2; other site 521098006140 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 521098006141 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 521098006142 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 521098006143 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 521098006144 dimer interface [polypeptide binding]; other site 521098006145 motif 1; other site 521098006146 active site 521098006147 motif 2; other site 521098006148 motif 3; other site 521098006149 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 521098006150 ATP-grasp domain; Region: ATP-grasp; pfam02222 521098006151 AIR carboxylase; Region: AIRC; pfam00731 521098006152 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 521098006153 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 521098006154 putative active site; other site 521098006155 catalytic residue [active] 521098006156 6-phosphofructokinase; Provisional; Region: PRK03202 521098006157 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 521098006158 active site 521098006159 ADP/pyrophosphate binding site [chemical binding]; other site 521098006160 dimerization interface [polypeptide binding]; other site 521098006161 allosteric effector site; other site 521098006162 fructose-1,6-bisphosphate binding site; other site 521098006163 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 521098006164 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 521098006165 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 521098006166 dimerization interface [polypeptide binding]; other site 521098006167 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 521098006168 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 521098006169 dimer interface [polypeptide binding]; other site 521098006170 putative CheW interface [polypeptide binding]; other site 521098006171 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 521098006172 dimerization domain swap beta strand [polypeptide binding]; other site 521098006173 regulatory protein interface [polypeptide binding]; other site 521098006174 active site 521098006175 regulatory phosphorylation site [posttranslational modification]; other site 521098006176 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 521098006177 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 521098006178 Walker A/P-loop; other site 521098006179 ATP binding site [chemical binding]; other site 521098006180 Q-loop/lid; other site 521098006181 ABC transporter signature motif; other site 521098006182 Walker B; other site 521098006183 D-loop; other site 521098006184 H-loop/switch region; other site 521098006185 TOBE domain; Region: TOBE; pfam03459 521098006186 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 521098006187 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 521098006188 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 521098006189 Malic enzyme, N-terminal domain; Region: malic; pfam00390 521098006190 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 521098006191 putative NAD(P) binding site [chemical binding]; other site 521098006192 malate:quinone oxidoreductase; Validated; Region: PRK05257 521098006193 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 521098006194 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 521098006195 E3 interaction surface; other site 521098006196 lipoyl attachment site [posttranslational modification]; other site 521098006197 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 521098006198 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 521098006199 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 521098006200 TPP-binding site [chemical binding]; other site 521098006201 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 521098006202 MoxR-like ATPases [General function prediction only]; Region: COG0714 521098006203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098006204 Walker A motif; other site 521098006205 ATP binding site [chemical binding]; other site 521098006206 Walker B motif; other site 521098006207 arginine finger; other site 521098006208 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 521098006209 Protein of unknown function DUF58; Region: DUF58; pfam01882 521098006210 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 521098006211 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 521098006212 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 521098006213 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 521098006214 dimerization interface [polypeptide binding]; other site 521098006215 ligand binding site [chemical binding]; other site 521098006216 NADP binding site [chemical binding]; other site 521098006217 catalytic site [active] 521098006218 Putative zinc-finger; Region: zf-HC2; pfam13490 521098006219 EamA-like transporter family; Region: EamA; pfam00892 521098006220 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521098006221 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521098006222 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 521098006223 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521098006224 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521098006225 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 521098006226 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 521098006227 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 521098006228 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 521098006229 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 521098006230 Domain found in IF2B/IF5; Region: eIF-5_eIF-2B; cl17014 521098006231 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 521098006232 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 521098006233 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 521098006234 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 521098006235 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521098006236 Coenzyme A binding pocket [chemical binding]; other site 521098006237 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 521098006238 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 521098006239 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 521098006240 dimanganese center [ion binding]; other site 521098006241 CotJB protein; Region: CotJB; pfam12652 521098006242 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 521098006243 Divergent PAP2 family; Region: DUF212; pfam02681 521098006244 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 521098006245 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 521098006246 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 521098006247 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 521098006248 23S rRNA binding site [nucleotide binding]; other site 521098006249 L21 binding site [polypeptide binding]; other site 521098006250 L13 binding site [polypeptide binding]; other site 521098006251 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 521098006252 translation initiation factor IF-3; Region: infC; TIGR00168 521098006253 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 521098006254 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 521098006255 Sulphur transport; Region: Sulf_transp; pfam04143 521098006256 Sulphur transport; Region: Sulf_transp; pfam04143 521098006257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098006258 S-adenosylmethionine binding site [chemical binding]; other site 521098006259 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 521098006260 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 521098006261 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 521098006262 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 521098006263 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 521098006264 active site 521098006265 dimer interface [polypeptide binding]; other site 521098006266 motif 1; other site 521098006267 motif 2; other site 521098006268 motif 3; other site 521098006269 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 521098006270 anticodon binding site; other site 521098006271 YtxC-like family; Region: YtxC; cl08500 521098006272 oligoendopeptidase F; Region: pepF; TIGR00181 521098006273 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 521098006274 Zn binding site [ion binding]; other site 521098006275 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 521098006276 active site 521098006277 catalytic residues [active] 521098006278 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 521098006279 N- and C-terminal domain interface [polypeptide binding]; other site 521098006280 D-xylulose kinase; Region: XylB; TIGR01312 521098006281 active site 521098006282 MgATP binding site [chemical binding]; other site 521098006283 catalytic site [active] 521098006284 metal binding site [ion binding]; metal-binding site 521098006285 xylulose binding site [chemical binding]; other site 521098006286 homodimer interface [polypeptide binding]; other site 521098006287 xylose isomerase; Provisional; Region: PRK05474 521098006288 xylose isomerase; Region: xylose_isom_A; TIGR02630 521098006289 benzoate transport; Region: 2A0115; TIGR00895 521098006290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098006291 putative substrate translocation pore; other site 521098006292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098006293 putative substrate translocation pore; other site 521098006294 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 521098006295 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521098006296 putative active site [active] 521098006297 putative metal binding site [ion binding]; other site 521098006298 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 521098006299 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 521098006300 active site 521098006301 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 521098006302 classical (c) SDRs; Region: SDR_c; cd05233 521098006303 NAD(P) binding site [chemical binding]; other site 521098006304 active site 521098006305 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 521098006306 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 521098006307 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 521098006308 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 521098006309 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 521098006310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098006311 sequence-specific DNA binding site [nucleotide binding]; other site 521098006312 salt bridge; other site 521098006313 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 521098006314 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 521098006315 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 521098006316 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 521098006317 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 521098006318 DNA-binding site [nucleotide binding]; DNA binding site 521098006319 RNA-binding motif; other site 521098006320 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 521098006321 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 521098006322 polypeptide substrate binding site [polypeptide binding]; other site 521098006323 active site 521098006324 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521098006325 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521098006326 active site 521098006327 catalytic tetrad [active] 521098006328 arsenical pump membrane protein; Provisional; Region: PRK15445 521098006329 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 521098006330 transmembrane helices; other site 521098006331 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 521098006332 conserved cys residue [active] 521098006333 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 521098006334 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 521098006335 Na binding site [ion binding]; other site 521098006336 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521098006337 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521098006338 active site 521098006339 catalytic tetrad [active] 521098006340 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 521098006341 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 521098006342 aromatic arch; other site 521098006343 DCoH dimer interaction site [polypeptide binding]; other site 521098006344 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 521098006345 DCoH tetramer interaction site [polypeptide binding]; other site 521098006346 substrate binding site [chemical binding]; other site 521098006347 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 521098006348 dimer interface [polypeptide binding]; other site 521098006349 ADP-ribose binding site [chemical binding]; other site 521098006350 active site 521098006351 nudix motif; other site 521098006352 metal binding site [ion binding]; metal-binding site 521098006353 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 521098006354 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 521098006355 Rhomboid family; Region: Rhomboid; pfam01694 521098006356 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521098006357 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 521098006358 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521098006359 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 521098006360 FtsX-like permease family; Region: FtsX; pfam02687 521098006361 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521098006362 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521098006363 Walker A/P-loop; other site 521098006364 ATP binding site [chemical binding]; other site 521098006365 Q-loop/lid; other site 521098006366 ABC transporter signature motif; other site 521098006367 Walker B; other site 521098006368 D-loop; other site 521098006369 H-loop/switch region; other site 521098006370 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 521098006371 HlyD family secretion protein; Region: HlyD_3; pfam13437 521098006372 FOG: CBS domain [General function prediction only]; Region: COG0517 521098006373 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 521098006374 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 521098006375 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 521098006376 dimer interface [polypeptide binding]; other site 521098006377 Citrate synthase; Region: Citrate_synt; pfam00285 521098006378 active site 521098006379 citrylCoA binding site [chemical binding]; other site 521098006380 oxalacetate/citrate binding site [chemical binding]; other site 521098006381 coenzyme A binding site [chemical binding]; other site 521098006382 catalytic triad [active] 521098006383 Domain of unknown function DUF; Region: DUF204; pfam02659 521098006384 Domain of unknown function DUF; Region: DUF204; pfam02659 521098006385 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 521098006386 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 521098006387 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 521098006388 hypothetical protein; Provisional; Region: PRK14812 521098006389 substrate binding site [chemical binding]; other site 521098006390 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 521098006391 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 521098006392 substrate binding site [chemical binding]; other site 521098006393 ligand binding site [chemical binding]; other site 521098006394 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 521098006395 tartrate dehydrogenase; Region: TTC; TIGR02089 521098006396 ketol-acid reductoisomerase; Provisional; Region: PRK05479 521098006397 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 521098006398 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 521098006399 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 521098006400 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 521098006401 putative valine binding site [chemical binding]; other site 521098006402 dimer interface [polypeptide binding]; other site 521098006403 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 521098006404 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 521098006405 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 521098006406 PYR/PP interface [polypeptide binding]; other site 521098006407 dimer interface [polypeptide binding]; other site 521098006408 TPP binding site [chemical binding]; other site 521098006409 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 521098006410 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 521098006411 TPP-binding site [chemical binding]; other site 521098006412 dimer interface [polypeptide binding]; other site 521098006413 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 521098006414 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 521098006415 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 521098006416 homodimer interface [polypeptide binding]; other site 521098006417 substrate-cofactor binding pocket; other site 521098006418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098006419 catalytic residue [active] 521098006420 homoserine dehydrogenase; Provisional; Region: PRK06349 521098006421 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 521098006422 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 521098006423 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 521098006424 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 521098006425 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 521098006426 putative substrate binding site [chemical binding]; other site 521098006427 putative ATP binding site [chemical binding]; other site 521098006428 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 521098006429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098006430 dimer interface [polypeptide binding]; other site 521098006431 conserved gate region; other site 521098006432 putative PBP binding loops; other site 521098006433 ABC-ATPase subunit interface; other site 521098006434 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 521098006435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098006436 dimer interface [polypeptide binding]; other site 521098006437 conserved gate region; other site 521098006438 putative PBP binding loops; other site 521098006439 ABC-ATPase subunit interface; other site 521098006440 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 521098006441 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 521098006442 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521098006443 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521098006444 DNA binding site [nucleotide binding] 521098006445 domain linker motif; other site 521098006446 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 521098006447 dimerization interface [polypeptide binding]; other site 521098006448 ligand binding site [chemical binding]; other site 521098006449 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521098006450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098006451 non-specific DNA binding site [nucleotide binding]; other site 521098006452 salt bridge; other site 521098006453 sequence-specific DNA binding site [nucleotide binding]; other site 521098006454 PBP superfamily domain; Region: PBP_like; pfam12727 521098006455 molybdate ABC transporter periplasmic substrate-binding protein; Provisional; Region: PRK04168 521098006456 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 521098006457 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 521098006458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098006459 dimer interface [polypeptide binding]; other site 521098006460 conserved gate region; other site 521098006461 putative PBP binding loops; other site 521098006462 ABC-ATPase subunit interface; other site 521098006463 peroxiredoxin; Provisional; Region: PRK13189 521098006464 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 521098006465 dimer interface [polypeptide binding]; other site 521098006466 decamer (pentamer of dimers) interface [polypeptide binding]; other site 521098006467 catalytic triad [active] 521098006468 Rrf2 family protein; Region: rrf2_super; TIGR00738 521098006469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521098006470 DNA-binding site [nucleotide binding]; DNA binding site 521098006471 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 521098006472 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 521098006473 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521098006474 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521098006475 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 521098006476 active site 521098006477 lysine transporter; Provisional; Region: PRK10836 521098006478 Stage II sporulation protein; Region: SpoIID; pfam08486 521098006479 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521098006480 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521098006481 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 521098006482 Walker A/P-loop; other site 521098006483 ATP binding site [chemical binding]; other site 521098006484 Q-loop/lid; other site 521098006485 ABC transporter signature motif; other site 521098006486 Walker B; other site 521098006487 D-loop; other site 521098006488 H-loop/switch region; other site 521098006489 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521098006490 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521098006491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521098006492 Walker A/P-loop; other site 521098006493 ATP binding site [chemical binding]; other site 521098006494 Q-loop/lid; other site 521098006495 ABC transporter signature motif; other site 521098006496 Walker B; other site 521098006497 D-loop; other site 521098006498 H-loop/switch region; other site 521098006499 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 521098006500 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 521098006501 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 521098006502 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 521098006503 peptide binding site [polypeptide binding]; other site 521098006504 dimer interface [polypeptide binding]; other site 521098006505 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 521098006506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098006507 dimer interface [polypeptide binding]; other site 521098006508 conserved gate region; other site 521098006509 putative PBP binding loops; other site 521098006510 ABC-ATPase subunit interface; other site 521098006511 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 521098006512 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 521098006513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098006514 dimer interface [polypeptide binding]; other site 521098006515 conserved gate region; other site 521098006516 ABC-ATPase subunit interface; other site 521098006517 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 521098006518 peptide binding site [polypeptide binding]; other site 521098006519 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 521098006520 dimer interface [polypeptide binding]; other site 521098006521 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 521098006522 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 521098006523 Walker A/P-loop; other site 521098006524 ATP binding site [chemical binding]; other site 521098006525 Q-loop/lid; other site 521098006526 ABC transporter signature motif; other site 521098006527 Walker B; other site 521098006528 D-loop; other site 521098006529 H-loop/switch region; other site 521098006530 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 521098006531 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 521098006532 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 521098006533 Walker A/P-loop; other site 521098006534 ATP binding site [chemical binding]; other site 521098006535 Q-loop/lid; other site 521098006536 ABC transporter signature motif; other site 521098006537 Walker B; other site 521098006538 D-loop; other site 521098006539 H-loop/switch region; other site 521098006540 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 521098006541 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521098006542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098006543 active site 521098006544 phosphorylation site [posttranslational modification] 521098006545 intermolecular recognition site; other site 521098006546 dimerization interface [polypeptide binding]; other site 521098006547 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521098006548 DNA binding site [nucleotide binding] 521098006549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521098006550 dimer interface [polypeptide binding]; other site 521098006551 phosphorylation site [posttranslational modification] 521098006552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098006553 ATP binding site [chemical binding]; other site 521098006554 Mg2+ binding site [ion binding]; other site 521098006555 G-X-G motif; other site 521098006556 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 521098006557 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 521098006558 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521098006559 dimer interface [polypeptide binding]; other site 521098006560 phosphorylation site [posttranslational modification] 521098006561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098006562 ATP binding site [chemical binding]; other site 521098006563 Mg2+ binding site [ion binding]; other site 521098006564 G-X-G motif; other site 521098006565 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521098006566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098006567 active site 521098006568 phosphorylation site [posttranslational modification] 521098006569 intermolecular recognition site; other site 521098006570 dimerization interface [polypeptide binding]; other site 521098006571 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521098006572 DNA binding site [nucleotide binding] 521098006573 Transcriptional regulator [Transcription]; Region: LysR; COG0583 521098006574 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 521098006575 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 521098006576 dimerization interface [polypeptide binding]; other site 521098006577 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 521098006578 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 521098006579 GDP-binding site [chemical binding]; other site 521098006580 ACT binding site; other site 521098006581 IMP binding site; other site 521098006582 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 521098006583 active site 521098006584 putative catalytic site [active] 521098006585 DNA binding site [nucleotide binding] 521098006586 putative phosphate binding site [ion binding]; other site 521098006587 metal binding site A [ion binding]; metal-binding site 521098006588 AP binding site [nucleotide binding]; other site 521098006589 metal binding site B [ion binding]; metal-binding site 521098006590 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 521098006591 Active site serine [active] 521098006592 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 521098006593 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 521098006594 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 521098006595 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 521098006596 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 521098006597 pantothenate kinase; Provisional; Region: PRK05439 521098006598 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 521098006599 ATP-binding site [chemical binding]; other site 521098006600 CoA-binding site [chemical binding]; other site 521098006601 Mg2+-binding site [ion binding]; other site 521098006602 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 521098006603 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 521098006604 substrate binding site [chemical binding]; other site 521098006605 dimer interface [polypeptide binding]; other site 521098006606 ATP binding site [chemical binding]; other site 521098006607 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 521098006608 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 521098006609 ligand binding site [chemical binding]; other site 521098006610 dimerization interface [polypeptide binding]; other site 521098006611 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 521098006612 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 521098006613 TM-ABC transporter signature motif; other site 521098006614 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 521098006615 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 521098006616 Walker A/P-loop; other site 521098006617 ATP binding site [chemical binding]; other site 521098006618 Q-loop/lid; other site 521098006619 ABC transporter signature motif; other site 521098006620 Walker B; other site 521098006621 D-loop; other site 521098006622 H-loop/switch region; other site 521098006623 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 521098006624 D-ribose pyranase; Provisional; Region: PRK11797 521098006625 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521098006626 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521098006627 DNA binding site [nucleotide binding] 521098006628 domain linker motif; other site 521098006629 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 521098006630 dimerization interface [polypeptide binding]; other site 521098006631 ligand binding site [chemical binding]; other site 521098006632 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521098006633 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521098006634 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 521098006635 Walker A/P-loop; other site 521098006636 ATP binding site [chemical binding]; other site 521098006637 Q-loop/lid; other site 521098006638 ABC transporter signature motif; other site 521098006639 Walker B; other site 521098006640 D-loop; other site 521098006641 H-loop/switch region; other site 521098006642 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521098006643 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521098006644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521098006645 Walker A/P-loop; other site 521098006646 ATP binding site [chemical binding]; other site 521098006647 Q-loop/lid; other site 521098006648 ABC transporter signature motif; other site 521098006649 Walker B; other site 521098006650 D-loop; other site 521098006651 H-loop/switch region; other site 521098006652 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 521098006653 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521098006654 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 521098006655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521098006656 Uncharacterized conserved protein [Function unknown]; Region: COG2427 521098006657 methionine sulfoxide reductase B; Provisional; Region: PRK00222 521098006658 SelR domain; Region: SelR; pfam01641 521098006659 Uncharacterized conserved protein [Function unknown]; Region: COG1434 521098006660 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 521098006661 putative active site [active] 521098006662 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 521098006663 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 521098006664 active site 521098006665 mannonate dehydratase; Region: uxuA; TIGR00695 521098006666 mannonate dehydratase; Provisional; Region: PRK03906 521098006667 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 521098006668 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 521098006669 active site 521098006670 intersubunit interface [polypeptide binding]; other site 521098006671 catalytic residue [active] 521098006672 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 521098006673 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 521098006674 substrate binding site [chemical binding]; other site 521098006675 ATP binding site [chemical binding]; other site 521098006676 Glycerate kinase family; Region: Gly_kinase; cl00841 521098006677 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 521098006678 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cl01317 521098006679 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 521098006680 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 521098006681 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 521098006682 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 521098006683 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 521098006684 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 521098006685 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 521098006686 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 521098006687 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 521098006688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098006689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521098006690 putative substrate translocation pore; other site 521098006691 LabA_like proteins; Region: LabA; cd10911 521098006692 Uncharacterized conserved protein [Function unknown]; Region: COG1432 521098006693 putative metal binding site [ion binding]; other site 521098006694 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 521098006695 ROK family; Region: ROK; pfam00480 521098006696 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 521098006697 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 521098006698 dimerization interface [polypeptide binding]; other site 521098006699 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 521098006700 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 521098006701 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 521098006702 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 521098006703 multimer interface [polypeptide binding]; other site 521098006704 active site 521098006705 catalytic triad [active] 521098006706 dimer interface [polypeptide binding]; other site 521098006707 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 521098006708 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 521098006709 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 521098006710 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521098006711 Zn2+ binding site [ion binding]; other site 521098006712 Mg2+ binding site [ion binding]; other site 521098006713 Transposase domain (DUF772); Region: DUF772; pfam05598 521098006714 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 521098006715 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 521098006716 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 521098006717 polyphosphate kinase; Provisional; Region: PRK05443 521098006718 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 521098006719 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 521098006720 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 521098006721 putative domain interface [polypeptide binding]; other site 521098006722 putative active site [active] 521098006723 catalytic site [active] 521098006724 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 521098006725 putative domain interface [polypeptide binding]; other site 521098006726 putative active site [active] 521098006727 catalytic site [active] 521098006728 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 521098006729 drug efflux system protein MdtG; Provisional; Region: PRK09874 521098006730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098006731 putative substrate translocation pore; other site 521098006732 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 521098006733 Coat F domain; Region: Coat_F; pfam07875 521098006734 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 521098006735 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521098006736 DNA-binding site [nucleotide binding]; DNA binding site 521098006737 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 521098006738 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 521098006739 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 521098006740 dimer interface [polypeptide binding]; other site 521098006741 active site 521098006742 galactokinase; Provisional; Region: PRK05322 521098006743 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 521098006744 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 521098006745 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 521098006746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521098006747 Coenzyme A binding pocket [chemical binding]; other site 521098006748 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 521098006749 VIT family; Region: VIT1; pfam01988 521098006750 L-idonate 5-dehydrogenase; Region: PLN02702 521098006751 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 521098006752 inhibitor binding site; inhibition site 521098006753 catalytic Zn binding site [ion binding]; other site 521098006754 structural Zn binding site [ion binding]; other site 521098006755 NADP binding site [chemical binding]; other site 521098006756 tetramer interface [polypeptide binding]; other site 521098006757 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 521098006758 Mechanosensitive ion channel; Region: MS_channel; pfam00924 521098006759 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 521098006760 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521098006761 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 521098006762 O-Antigen ligase; Region: Wzy_C; cl04850 521098006763 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 521098006764 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 521098006765 DXD motif; other site 521098006766 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 521098006767 active site 521098006768 dimer interface [polypeptide binding]; other site 521098006769 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 521098006770 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 521098006771 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 521098006772 HTH domain; Region: HTH_11; pfam08279 521098006773 3H domain; Region: 3H; pfam02829 521098006774 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 521098006775 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 521098006776 N-acetyl-D-glucosamine binding site [chemical binding]; other site 521098006777 catalytic residue [active] 521098006778 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 521098006779 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 521098006780 CoA-binding site [chemical binding]; other site 521098006781 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 521098006782 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 521098006783 DNA binding site [nucleotide binding] 521098006784 catalytic residue [active] 521098006785 H2TH interface [polypeptide binding]; other site 521098006786 putative catalytic residues [active] 521098006787 turnover-facilitating residue; other site 521098006788 intercalation triad [nucleotide binding]; other site 521098006789 8OG recognition residue [nucleotide binding]; other site 521098006790 putative reading head residues; other site 521098006791 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 521098006792 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 521098006793 DNA polymerase I; Provisional; Region: PRK05755 521098006794 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 521098006795 active site 521098006796 metal binding site 1 [ion binding]; metal-binding site 521098006797 putative 5' ssDNA interaction site; other site 521098006798 metal binding site 3; metal-binding site 521098006799 metal binding site 2 [ion binding]; metal-binding site 521098006800 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 521098006801 putative DNA binding site [nucleotide binding]; other site 521098006802 putative metal binding site [ion binding]; other site 521098006803 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 521098006804 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 521098006805 active site 521098006806 DNA binding site [nucleotide binding] 521098006807 catalytic site [active] 521098006808 Chorismate mutase type II; Region: CM_2; smart00830 521098006809 malate dehydrogenase; Reviewed; Region: PRK06223 521098006810 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 521098006811 NAD(P) binding site [chemical binding]; other site 521098006812 dimer interface [polypeptide binding]; other site 521098006813 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521098006814 substrate binding site [chemical binding]; other site 521098006815 isocitrate dehydrogenase; Validated; Region: PRK07362 521098006816 isocitrate dehydrogenase; Reviewed; Region: PRK07006 521098006817 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521098006818 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521098006819 dimer interface [polypeptide binding]; other site 521098006820 phosphorylation site [posttranslational modification] 521098006821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098006822 ATP binding site [chemical binding]; other site 521098006823 Mg2+ binding site [ion binding]; other site 521098006824 G-X-G motif; other site 521098006825 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521098006826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098006827 active site 521098006828 phosphorylation site [posttranslational modification] 521098006829 intermolecular recognition site; other site 521098006830 dimerization interface [polypeptide binding]; other site 521098006831 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521098006832 DNA binding site [nucleotide binding] 521098006833 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 521098006834 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 521098006835 active site 521098006836 HIGH motif; other site 521098006837 dimer interface [polypeptide binding]; other site 521098006838 KMSKS motif; other site 521098006839 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 521098006840 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 521098006841 domain interfaces; other site 521098006842 active site 521098006843 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 521098006844 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 521098006845 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 521098006846 4-aminobutyrate transaminase; Provisional; Region: PRK09792 521098006847 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 521098006848 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 521098006849 active site 521098006850 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 521098006851 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 521098006852 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521098006853 DNA-binding site [nucleotide binding]; DNA binding site 521098006854 DRTGG domain; Region: DRTGG; pfam07085 521098006855 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 521098006856 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 521098006857 active site 2 [active] 521098006858 active site 1 [active] 521098006859 Uncharacterized conserved protein [Function unknown]; Region: COG1284 521098006860 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 521098006861 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 521098006862 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 521098006863 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 521098006864 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 521098006865 dimer interface [polypeptide binding]; other site 521098006866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098006867 catalytic residue [active] 521098006868 arginine repressor; Provisional; Region: PRK04280 521098006869 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 521098006870 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 521098006871 DNA polymerase IV; Validated; Region: PRK01810 521098006872 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 521098006873 active site 521098006874 DNA binding site [nucleotide binding] 521098006875 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 521098006876 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 521098006877 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 521098006878 metal-dependent hydrolase; Provisional; Region: PRK00685 521098006879 Protein of unknown function (DUF964); Region: DUF964; cl01483 521098006880 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 521098006881 apolar tunnel; other site 521098006882 heme binding site [chemical binding]; other site 521098006883 dimerization interface [polypeptide binding]; other site 521098006884 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521098006885 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098006886 non-specific DNA binding site [nucleotide binding]; other site 521098006887 salt bridge; other site 521098006888 sequence-specific DNA binding site [nucleotide binding]; other site 521098006889 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 521098006890 Ligand Binding Site [chemical binding]; other site 521098006891 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 521098006892 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 521098006893 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521098006894 active site 521098006895 HIGH motif; other site 521098006896 nucleotide binding site [chemical binding]; other site 521098006897 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 521098006898 active site 521098006899 KMSKS motif; other site 521098006900 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 521098006901 tRNA binding surface [nucleotide binding]; other site 521098006902 anticodon binding site; other site 521098006903 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521098006904 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 521098006905 TAP-like protein; Region: Abhydrolase_4; pfam08386 521098006906 serine O-acetyltransferase; Region: cysE; TIGR01172 521098006907 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 521098006908 trimer interface [polypeptide binding]; other site 521098006909 active site 521098006910 substrate binding site [chemical binding]; other site 521098006911 CoA binding site [chemical binding]; other site 521098006912 hypothetical protein; Provisional; Region: PRK08201 521098006913 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 521098006914 metal binding site [ion binding]; metal-binding site 521098006915 putative dimer interface [polypeptide binding]; other site 521098006916 transcriptional repressor CodY; Validated; Region: PRK04158 521098006917 CodY GAF-like domain; Region: CodY; pfam06018 521098006918 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 521098006919 Trp repressor protein; Region: Trp_repressor; cl17266 521098006920 Sulfocyanin (SoxE); Region: SoxE; cl17563 521098006921 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 521098006922 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 521098006923 Multicopper oxidase; Region: Cu-oxidase; pfam00394 521098006924 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 521098006925 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 521098006926 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521098006927 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098006928 non-specific DNA binding site [nucleotide binding]; other site 521098006929 salt bridge; other site 521098006930 sequence-specific DNA binding site [nucleotide binding]; other site 521098006931 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 521098006932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521098006933 Coenzyme A binding pocket [chemical binding]; other site 521098006934 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521098006935 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098006936 sequence-specific DNA binding site [nucleotide binding]; other site 521098006937 salt bridge; other site 521098006938 Domain of unknown function DUF87; Region: DUF87; pfam01935 521098006939 AAA-like domain; Region: AAA_10; pfam12846 521098006940 DNA methylase; Region: N6_N4_Mtase; cl17433 521098006941 prolyl-tRNA synthetase; Provisional; Region: PRK08661 521098006942 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 521098006943 dimer interface [polypeptide binding]; other site 521098006944 motif 1; other site 521098006945 active site 521098006946 motif 2; other site 521098006947 motif 3; other site 521098006948 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 521098006949 anticodon binding site; other site 521098006950 zinc-binding site [ion binding]; other site 521098006951 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 521098006952 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 521098006953 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 521098006954 putative NAD(P) binding site [chemical binding]; other site 521098006955 catalytic Zn binding site [ion binding]; other site 521098006956 structural Zn binding site [ion binding]; other site 521098006957 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 521098006958 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 521098006959 active site 521098006960 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521098006961 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 521098006962 acyl-activating enzyme (AAE) consensus motif; other site 521098006963 AMP binding site [chemical binding]; other site 521098006964 active site 521098006965 CoA binding site [chemical binding]; other site 521098006966 acyl carrier protein; Provisional; Region: acpP; PRK00982 521098006967 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 521098006968 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 521098006969 putative NAD(P) binding site [chemical binding]; other site 521098006970 active site 521098006971 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 521098006972 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 521098006973 active site 521098006974 FMN binding site [chemical binding]; other site 521098006975 2,4-decadienoyl-CoA binding site; other site 521098006976 catalytic residue [active] 521098006977 4Fe-4S cluster binding site [ion binding]; other site 521098006978 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 521098006979 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 521098006980 acyl-activating enzyme (AAE) consensus motif; other site 521098006981 putative AMP binding site [chemical binding]; other site 521098006982 putative active site [active] 521098006983 putative CoA binding site [chemical binding]; other site 521098006984 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 521098006985 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 521098006986 active site 521098006987 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 521098006988 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 521098006989 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 521098006990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 521098006991 potassium/proton antiporter; Reviewed; Region: PRK05326 521098006992 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 521098006993 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 521098006994 TrkA-C domain; Region: TrkA_C; pfam02080 521098006995 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 521098006996 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 521098006997 classical (c) SDRs; Region: SDR_c; cd05233 521098006998 NAD(P) binding site [chemical binding]; other site 521098006999 active site 521098007000 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 521098007001 active site 521098007002 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 521098007003 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 521098007004 putative NAD(P) binding site [chemical binding]; other site 521098007005 active site 521098007006 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 521098007007 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 521098007008 dimer interface [polypeptide binding]; other site 521098007009 active site 521098007010 BNR repeat-like domain; Region: BNR_2; pfam13088 521098007011 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521098007012 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521098007013 active site 521098007014 catalytic tetrad [active] 521098007015 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 521098007016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521098007017 motif II; other site 521098007018 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 521098007019 dimerization interface [polypeptide binding]; other site 521098007020 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 521098007021 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 521098007022 dimer interface [polypeptide binding]; other site 521098007023 putative CheW interface [polypeptide binding]; other site 521098007024 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 521098007025 CoenzymeA binding site [chemical binding]; other site 521098007026 subunit interaction site [polypeptide binding]; other site 521098007027 PHB binding site; other site 521098007028 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 521098007029 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 521098007030 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 521098007031 putative active site [active] 521098007032 putative substrate binding site [chemical binding]; other site 521098007033 putative cosubstrate binding site; other site 521098007034 catalytic site [active] 521098007035 Small nuclear ribonucleoprotein (snRNP) homolog [Transcription]; Region: LSM1; COG1958 521098007036 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 521098007037 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 521098007038 putative active site [active] 521098007039 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 521098007040 putative active site [active] 521098007041 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 521098007042 active site 521098007043 SAM binding site [chemical binding]; other site 521098007044 homodimer interface [polypeptide binding]; other site 521098007045 sulfite reductase subunit beta; Provisional; Region: PRK13504 521098007046 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 521098007047 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 521098007048 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 521098007049 Active Sites [active] 521098007050 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 521098007051 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 521098007052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098007053 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521098007054 putative substrate translocation pore; other site 521098007055 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 521098007056 HlyD family secretion protein; Region: HlyD_3; pfam13437 521098007057 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 521098007058 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521098007059 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 521098007060 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 521098007061 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 521098007062 DXD motif; other site 521098007063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 521098007064 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 521098007065 NlpC/P60 family; Region: NLPC_P60; pfam00877 521098007066 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 521098007067 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 521098007068 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521098007069 putative metal binding site [ion binding]; other site 521098007070 Spore germination protein; Region: Spore_permease; cl17796 521098007071 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 521098007072 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 521098007073 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 521098007074 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521098007075 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521098007076 protein binding site [polypeptide binding]; other site 521098007077 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 521098007078 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521098007079 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 521098007080 active site lid residues [active] 521098007081 substrate binding pocket [chemical binding]; other site 521098007082 catalytic residues [active] 521098007083 substrate-Mg2+ binding site; other site 521098007084 aspartate-rich region 1; other site 521098007085 aspartate-rich region 2; other site 521098007086 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 521098007087 active site lid residues [active] 521098007088 substrate binding pocket [chemical binding]; other site 521098007089 catalytic residues [active] 521098007090 substrate-Mg2+ binding site; other site 521098007091 aspartate-rich region 1; other site 521098007092 aspartate-rich region 2; other site 521098007093 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 521098007094 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 521098007095 Active site cavity [active] 521098007096 catalytic acid [active] 521098007097 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 521098007098 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 521098007099 putative NADP binding site [chemical binding]; other site 521098007100 putative substrate binding site [chemical binding]; other site 521098007101 active site 521098007102 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 521098007103 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 521098007104 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521098007105 FeS/SAM binding site; other site 521098007106 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 521098007107 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 521098007108 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 521098007109 homotetramer interface [polypeptide binding]; other site 521098007110 FMN binding site [chemical binding]; other site 521098007111 homodimer contacts [polypeptide binding]; other site 521098007112 putative active site [active] 521098007113 putative substrate binding site [chemical binding]; other site 521098007114 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 521098007115 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 521098007116 TPP-binding site; other site 521098007117 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 521098007118 PYR/PP interface [polypeptide binding]; other site 521098007119 dimer interface [polypeptide binding]; other site 521098007120 TPP binding site [chemical binding]; other site 521098007121 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521098007122 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 521098007123 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 521098007124 polypeptide substrate binding site [polypeptide binding]; other site 521098007125 active site 521098007126 Acyltransferase family; Region: Acyl_transf_3; pfam01757 521098007127 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 521098007128 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 521098007129 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521098007130 acyl-activating enzyme (AAE) consensus motif; other site 521098007131 AMP binding site [chemical binding]; other site 521098007132 active site 521098007133 CoA binding site [chemical binding]; other site 521098007134 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 521098007135 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 521098007136 active site 521098007137 Zn binding site [ion binding]; other site 521098007138 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 521098007139 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 521098007140 Multicopper oxidase; Region: Cu-oxidase; pfam00394 521098007141 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 521098007142 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 521098007143 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 521098007144 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 521098007145 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 521098007146 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 521098007147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098007148 dimer interface [polypeptide binding]; other site 521098007149 conserved gate region; other site 521098007150 ABC-ATPase subunit interface; other site 521098007151 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 521098007152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098007153 dimer interface [polypeptide binding]; other site 521098007154 putative PBP binding loops; other site 521098007155 ABC-ATPase subunit interface; other site 521098007156 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 521098007157 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 521098007158 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521098007159 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521098007160 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521098007161 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 521098007162 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521098007163 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521098007164 DNA binding site [nucleotide binding] 521098007165 domain linker motif; other site 521098007166 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 521098007167 ligand binding site [chemical binding]; other site 521098007168 dimerization interface [polypeptide binding]; other site 521098007169 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 521098007170 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 521098007171 active site 521098007172 catalytic site [active] 521098007173 substrate binding site [chemical binding]; other site 521098007174 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 521098007175 metal binding triad; other site 521098007176 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 521098007177 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 521098007178 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 521098007179 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 521098007180 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 521098007181 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 521098007182 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 521098007183 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521098007184 motif II; other site 521098007185 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 521098007186 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 521098007187 Walker A/P-loop; other site 521098007188 ATP binding site [chemical binding]; other site 521098007189 Q-loop/lid; other site 521098007190 ABC transporter signature motif; other site 521098007191 Walker B; other site 521098007192 D-loop; other site 521098007193 H-loop/switch region; other site 521098007194 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 521098007195 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 521098007196 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 521098007197 Walker A/P-loop; other site 521098007198 ATP binding site [chemical binding]; other site 521098007199 Q-loop/lid; other site 521098007200 ABC transporter signature motif; other site 521098007201 Walker B; other site 521098007202 D-loop; other site 521098007203 H-loop/switch region; other site 521098007204 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 521098007205 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 521098007206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098007207 dimer interface [polypeptide binding]; other site 521098007208 conserved gate region; other site 521098007209 putative PBP binding loops; other site 521098007210 ABC-ATPase subunit interface; other site 521098007211 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 521098007212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098007213 dimer interface [polypeptide binding]; other site 521098007214 conserved gate region; other site 521098007215 putative PBP binding loops; other site 521098007216 ABC-ATPase subunit interface; other site 521098007217 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 521098007218 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 521098007219 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 521098007220 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 521098007221 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 521098007222 quinolinate synthetase; Provisional; Region: PRK09375 521098007223 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 521098007224 L-aspartate oxidase; Provisional; Region: PRK06175 521098007225 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 521098007226 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 521098007227 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 521098007228 dimerization interface [polypeptide binding]; other site 521098007229 active site 521098007230 Radical SAM superfamily; Region: Radical_SAM; pfam04055 521098007231 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 521098007232 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 521098007233 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 521098007234 ATP binding site [chemical binding]; other site 521098007235 substrate interface [chemical binding]; other site 521098007236 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 521098007237 ThiS interaction site; other site 521098007238 putative active site [active] 521098007239 tetramer interface [polypeptide binding]; other site 521098007240 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 521098007241 thiS-thiF/thiG interaction site; other site 521098007242 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 521098007243 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 521098007244 active site 521098007245 thiamine phosphate binding site [chemical binding]; other site 521098007246 pyrophosphate binding site [ion binding]; other site 521098007247 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 521098007248 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 521098007249 DHHA2 domain; Region: DHHA2; pfam02833 521098007250 H+ Antiporter protein; Region: 2A0121; TIGR00900 521098007251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098007252 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521098007253 putative substrate translocation pore; other site 521098007254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098007255 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 521098007256 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 521098007257 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 521098007258 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 521098007259 peptide binding site [polypeptide binding]; other site 521098007260 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 521098007261 dimer interface [polypeptide binding]; other site 521098007262 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 521098007263 peptide binding site [polypeptide binding]; other site 521098007264 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 521098007265 dimer interface [polypeptide binding]; other site 521098007266 DinB superfamily; Region: DinB_2; pfam12867 521098007267 DinB family; Region: DinB; cl17821 521098007268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521098007269 TIGR01777 family protein; Region: yfcH 521098007270 NAD(P) binding site [chemical binding]; other site 521098007271 active site 521098007272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098007273 D-galactonate transporter; Region: 2A0114; TIGR00893 521098007274 putative substrate translocation pore; other site 521098007275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098007276 intracellular protease, PfpI family; Region: PfpI; TIGR01382 521098007277 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 521098007278 conserved cys residue [active] 521098007279 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 521098007280 dimer interface [polypeptide binding]; other site 521098007281 putative CheW interface [polypeptide binding]; other site 521098007282 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 521098007283 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 521098007284 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 521098007285 NAD(P) binding site [chemical binding]; other site 521098007286 catalytic residues [active] 521098007287 BclB C-terminal domain; Region: exospore_TM; TIGR03721 521098007288 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521098007289 active site 521098007290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521098007291 binding surface 521098007292 TPR motif; other site 521098007293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521098007294 binding surface 521098007295 TPR motif; other site 521098007296 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 521098007297 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 521098007298 substrate binding site [chemical binding]; other site 521098007299 Transcriptional regulator [Transcription]; Region: LysR; COG0583 521098007300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 521098007301 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 521098007302 putative dimerization interface [polypeptide binding]; other site 521098007303 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 521098007304 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 521098007305 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 521098007306 DNA binding residues [nucleotide binding] 521098007307 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 521098007308 catalytic residues [active] 521098007309 catalytic nucleophile [active] 521098007310 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 521098007311 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 521098007312 Probable transposase; Region: OrfB_IS605; pfam01385 521098007313 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 521098007314 D-galactonate transporter; Region: 2A0114; TIGR00893 521098007315 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 521098007316 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 521098007317 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 521098007318 NAD(P) binding site [chemical binding]; other site 521098007319 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 521098007320 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 521098007321 catalytic residue [active] 521098007322 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 521098007323 catalytic residues [active] 521098007324 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 521098007325 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521098007326 peroxiredoxin; Region: AhpC; TIGR03137 521098007327 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 521098007328 dimer interface [polypeptide binding]; other site 521098007329 decamer (pentamer of dimers) interface [polypeptide binding]; other site 521098007330 catalytic triad [active] 521098007331 peroxidatic and resolving cysteines [active] 521098007332 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 521098007333 metal binding site 2 [ion binding]; metal-binding site 521098007334 putative DNA binding helix; other site 521098007335 metal binding site 1 [ion binding]; metal-binding site 521098007336 dimer interface [polypeptide binding]; other site 521098007337 structural Zn2+ binding site [ion binding]; other site 521098007338 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 521098007339 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 521098007340 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 521098007341 Proline dehydrogenase; Region: Pro_dh; cl03282 521098007342 PAS domain; Region: PAS_9; pfam13426 521098007343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521098007344 putative active site [active] 521098007345 heme pocket [chemical binding]; other site 521098007346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 521098007347 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 521098007348 Walker A motif; other site 521098007349 ATP binding site [chemical binding]; other site 521098007350 Walker B motif; other site 521098007351 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 521098007352 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 521098007353 FAD binding domain; Region: FAD_binding_4; pfam01565 521098007354 putative sialic acid transporter; Region: 2A0112; TIGR00891 521098007355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098007356 putative substrate translocation pore; other site 521098007357 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 521098007358 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 521098007359 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521098007360 L-lactate permease; Region: Lactate_perm; cl00701 521098007361 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 521098007362 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 521098007363 malate synthase A; Region: malate_syn_A; TIGR01344 521098007364 active site 521098007365 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 521098007366 Transcriptional regulator [Transcription]; Region: IclR; COG1414 521098007367 Bacterial transcriptional regulator; Region: IclR; pfam01614 521098007368 FAD binding domain; Region: FAD_binding_4; pfam01565 521098007369 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 521098007370 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 521098007371 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 521098007372 Cysteine-rich domain; Region: CCG; pfam02754 521098007373 Cysteine-rich domain; Region: CCG; pfam02754 521098007374 FAD binding domain; Region: FAD_binding_4; pfam01565 521098007375 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 521098007376 N-glycosyltransferase; Provisional; Region: PRK11204 521098007377 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 521098007378 DXD motif; other site 521098007379 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 521098007380 PgaD-like protein; Region: PgaD; cl14676 521098007381 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 521098007382 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 521098007383 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 521098007384 catalytic residues [active] 521098007385 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521098007386 dimerization interface [polypeptide binding]; other site 521098007387 putative DNA binding site [nucleotide binding]; other site 521098007388 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 521098007389 putative hydrophobic ligand binding site [chemical binding]; other site 521098007390 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 521098007391 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 521098007392 active site 521098007393 DNA binding site [nucleotide binding] 521098007394 Int/Topo IB signature motif; other site 521098007395 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 521098007396 active site 521098007397 Int/Topo IB signature motif; other site 521098007398 DNA binding site [nucleotide binding] 521098007399 Replication-relaxation; Region: Replic_Relax; pfam13814 521098007400 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 521098007401 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 521098007402 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 521098007403 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 521098007404 peptide chain release factor 2; Validated; Region: prfB; PRK00578 521098007405 This domain is found in peptide chain release factors; Region: PCRF; smart00937 521098007406 RF-1 domain; Region: RF-1; pfam00472 521098007407 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 521098007408 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 521098007409 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521098007410 nucleotide binding region [chemical binding]; other site 521098007411 ATP-binding site [chemical binding]; other site 521098007412 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 521098007413 30S subunit binding site; other site 521098007414 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 521098007415 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 521098007416 active site 521098007417 hypothetical protein; Provisional; Region: PRK08317 521098007418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098007419 S-adenosylmethionine binding site [chemical binding]; other site 521098007420 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521098007421 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 521098007422 putative metal binding site; other site 521098007423 Flagellar protein FliS; Region: FliS; cl00654 521098007424 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 521098007425 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 521098007426 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 521098007427 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 521098007428 flagellin; Provisional; Region: PRK12802 521098007429 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 521098007430 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 521098007431 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 521098007432 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 521098007433 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 521098007434 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 521098007435 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 521098007436 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The...; Region: SANT; cl17250 521098007437 flagellar operon protein TIGR03826; Region: YvyF 521098007438 comF family protein; Region: comF; TIGR00201 521098007439 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521098007440 active site 521098007441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 521098007442 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 521098007443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521098007444 putative active site [active] 521098007445 heme pocket [chemical binding]; other site 521098007446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521098007447 dimer interface [polypeptide binding]; other site 521098007448 phosphorylation site [posttranslational modification] 521098007449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098007450 ATP binding site [chemical binding]; other site 521098007451 Mg2+ binding site [ion binding]; other site 521098007452 G-X-G motif; other site 521098007453 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521098007454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098007455 active site 521098007456 phosphorylation site [posttranslational modification] 521098007457 intermolecular recognition site; other site 521098007458 dimerization interface [polypeptide binding]; other site 521098007459 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521098007460 DNA binding site [nucleotide binding] 521098007461 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 521098007462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098007463 active site 521098007464 phosphorylation site [posttranslational modification] 521098007465 intermolecular recognition site; other site 521098007466 dimerization interface [polypeptide binding]; other site 521098007467 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 521098007468 DNA binding residues [nucleotide binding] 521098007469 dimerization interface [polypeptide binding]; other site 521098007470 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 521098007471 S-adenosylmethionine synthetase; Validated; Region: PRK05250 521098007472 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 521098007473 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 521098007474 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 521098007475 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 521098007476 drug efflux system protein MdtG; Provisional; Region: PRK09874 521098007477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098007478 putative substrate translocation pore; other site 521098007479 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 521098007480 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 521098007481 active site 521098007482 substrate binding site [chemical binding]; other site 521098007483 metal binding site [ion binding]; metal-binding site 521098007484 Dienelactone hydrolase family; Region: DLH; pfam01738 521098007485 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 521098007486 MPT binding site; other site 521098007487 trimer interface [polypeptide binding]; other site 521098007488 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 521098007489 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 521098007490 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521098007491 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 521098007492 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 521098007493 ABC1 family; Region: ABC1; cl17513 521098007494 Uncharacterized conserved protein [Function unknown]; Region: COG3937 521098007495 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 521098007496 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521098007497 RNA binding surface [nucleotide binding]; other site 521098007498 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 521098007499 active site 521098007500 uracil binding [chemical binding]; other site 521098007501 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 521098007502 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 521098007503 ApbE family; Region: ApbE; pfam02424 521098007504 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 521098007505 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521098007506 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521098007507 DNA binding site [nucleotide binding] 521098007508 domain linker motif; other site 521098007509 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 521098007510 ligand binding site [chemical binding]; other site 521098007511 dimerization interface [polypeptide binding]; other site 521098007512 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521098007513 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521098007514 active site 521098007515 catalytic tetrad [active] 521098007516 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 521098007517 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 521098007518 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 521098007519 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521098007520 catalytic residues [active] 521098007521 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 521098007522 active site 521098007523 catalytic triad [active] 521098007524 oxyanion hole [active] 521098007525 ApbE family; Region: ApbE; pfam02424 521098007526 FMN-binding domain; Region: FMN_bind; cl01081 521098007527 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 521098007528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098007529 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521098007530 putative substrate translocation pore; other site 521098007531 Pantoate-beta-alanine ligase; Region: PanC; cd00560 521098007532 pantoate--beta-alanine ligase; Region: panC; TIGR00018 521098007533 active site 521098007534 ATP-binding site [chemical binding]; other site 521098007535 pantoate-binding site; other site 521098007536 HXXH motif; other site 521098007537 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 521098007538 oligomerization interface [polypeptide binding]; other site 521098007539 active site 521098007540 metal binding site [ion binding]; metal-binding site 521098007541 Rossmann-like domain; Region: Rossmann-like; pfam10727 521098007542 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 521098007543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098007544 putative substrate translocation pore; other site 521098007545 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521098007546 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 521098007547 metal binding site 2 [ion binding]; metal-binding site 521098007548 putative DNA binding helix; other site 521098007549 metal binding site 1 [ion binding]; metal-binding site 521098007550 dimer interface [polypeptide binding]; other site 521098007551 structural Zn2+ binding site [ion binding]; other site 521098007552 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 521098007553 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 521098007554 intersubunit interface [polypeptide binding]; other site 521098007555 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 521098007556 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 521098007557 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 521098007558 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 521098007559 ABC-ATPase subunit interface; other site 521098007560 dimer interface [polypeptide binding]; other site 521098007561 putative PBP binding regions; other site 521098007562 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 521098007563 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 521098007564 putative PBP binding regions; other site 521098007565 ABC-ATPase subunit interface; other site 521098007566 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 521098007567 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521098007568 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521098007569 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 521098007570 FOG: WD40 repeat [General function prediction only]; Region: COG2319 521098007571 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 521098007572 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 521098007573 PAS domain; Region: PAS_9; pfam13426 521098007574 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 521098007575 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 521098007576 metal binding site [ion binding]; metal-binding site 521098007577 active site 521098007578 I-site; other site 521098007579 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 521098007580 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521098007581 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521098007582 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 521098007583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098007584 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521098007585 putative substrate translocation pore; other site 521098007586 CopC domain; Region: CopC; pfam04234 521098007587 Copper resistance protein D; Region: CopD; cl00563 521098007588 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 521098007589 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 521098007590 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 521098007591 MarR family; Region: MarR_2; pfam12802 521098007592 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 521098007593 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 521098007594 nucleotide binding site [chemical binding]; other site 521098007595 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 521098007596 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 521098007597 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 521098007598 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 521098007599 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 521098007600 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 521098007601 active site 521098007602 Putative zinc-finger; Region: zf-HC2; pfam13490 521098007603 Helix-turn-helix domain; Region: HTH_16; pfam12645 521098007604 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 521098007605 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521098007606 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521098007607 DNA binding residues [nucleotide binding] 521098007608 CRISPR-associated protein GSU0054/csb2, Dpsyc system; Region: cas_GSU0054; TIGR02165 521098007609 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 521098007610 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 521098007611 active site 2 [active] 521098007612 active site 1 [active] 521098007613 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 521098007614 active site 2 [active] 521098007615 active site 1 [active] 521098007616 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 521098007617 putative homodimer interface [polypeptide binding]; other site 521098007618 putative homotetramer interface [polypeptide binding]; other site 521098007619 putative metal binding site [ion binding]; other site 521098007620 putative homodimer-homodimer interface [polypeptide binding]; other site 521098007621 putative allosteric switch controlling residues; other site 521098007622 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 521098007623 Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712 521098007624 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 521098007625 active site residue [active] 521098007626 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 521098007627 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 521098007628 CPxP motif; other site 521098007629 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 521098007630 active site residue [active] 521098007631 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 521098007632 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 521098007633 active site residue [active] 521098007634 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 521098007635 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 521098007636 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 521098007637 CRISPR-associated protein Csx17, subtype Dpsyc; Region: cas_csx17; TIGR04113 521098007638 CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767 521098007639 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 521098007640 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 521098007641 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 521098007642 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 521098007643 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 521098007644 CRISPR-associated protein Cas4; Region: cas4; TIGR00372 521098007645 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 521098007646 ThiC-associated domain; Region: ThiC-associated; pfam13667 521098007647 ThiC family; Region: ThiC; pfam01964 521098007648 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 521098007649 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 521098007650 Na binding site [ion binding]; other site 521098007651 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 521098007652 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 521098007653 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 521098007654 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 521098007655 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 521098007656 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 521098007657 metal-binding site [ion binding] 521098007658 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 521098007659 putative homodimer interface [polypeptide binding]; other site 521098007660 putative homotetramer interface [polypeptide binding]; other site 521098007661 putative allosteric switch controlling residues; other site 521098007662 putative metal binding site [ion binding]; other site 521098007663 putative homodimer-homodimer interface [polypeptide binding]; other site 521098007664 Asp23 family; Region: Asp23; pfam03780 521098007665 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 521098007666 Asp23 family; Region: Asp23; pfam03780 521098007667 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 521098007668 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 521098007669 AsnC family; Region: AsnC_trans_reg; pfam01037 521098007670 hypothetical protein; Validated; Region: PRK07682 521098007671 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521098007672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098007673 homodimer interface [polypeptide binding]; other site 521098007674 catalytic residue [active] 521098007675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098007676 putative substrate translocation pore; other site 521098007677 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521098007678 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 521098007679 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 521098007680 putative NAD(P) binding site [chemical binding]; other site 521098007681 putative substrate binding site [chemical binding]; other site 521098007682 catalytic Zn binding site [ion binding]; other site 521098007683 structural Zn binding site [ion binding]; other site 521098007684 dimer interface [polypeptide binding]; other site 521098007685 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 521098007686 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 521098007687 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 521098007688 aminotransferase; Validated; Region: PRK07678 521098007689 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 521098007690 inhibitor-cofactor binding pocket; inhibition site 521098007691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098007692 catalytic residue [active] 521098007693 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 521098007694 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 521098007695 glutaminase active site [active] 521098007696 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 521098007697 dimer interface [polypeptide binding]; other site 521098007698 active site 521098007699 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 521098007700 dimer interface [polypeptide binding]; other site 521098007701 active site 521098007702 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 521098007703 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 521098007704 active site 521098007705 substrate binding site [chemical binding]; other site 521098007706 metal binding site [ion binding]; metal-binding site 521098007707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 521098007708 Uncharacterized conserved protein [Function unknown]; Region: COG1624 521098007709 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 521098007710 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 521098007711 active site 521098007712 catalytic triad [active] 521098007713 oxyanion hole [active] 521098007714 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 521098007715 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 521098007716 NodB motif; other site 521098007717 putative active site [active] 521098007718 putative catalytic site [active] 521098007719 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 521098007720 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 521098007721 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 521098007722 Walker A motif; other site 521098007723 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 521098007724 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 521098007725 active site 521098007726 metal binding site [ion binding]; metal-binding site 521098007727 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 521098007728 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 521098007729 23S rRNA interface [nucleotide binding]; other site 521098007730 L3 interface [polypeptide binding]; other site 521098007731 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 521098007732 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 521098007733 dimerization interface 3.5A [polypeptide binding]; other site 521098007734 active site 521098007735 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 521098007736 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 521098007737 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 521098007738 alphaNTD homodimer interface [polypeptide binding]; other site 521098007739 alphaNTD - beta interaction site [polypeptide binding]; other site 521098007740 alphaNTD - beta' interaction site [polypeptide binding]; other site 521098007741 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 521098007742 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 521098007743 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 521098007744 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521098007745 RNA binding surface [nucleotide binding]; other site 521098007746 30S ribosomal protein S11; Validated; Region: PRK05309 521098007747 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 521098007748 30S ribosomal protein S13; Region: bact_S13; TIGR03631 521098007749 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 521098007750 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 521098007751 rRNA binding site [nucleotide binding]; other site 521098007752 predicted 30S ribosome binding site; other site 521098007753 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 521098007754 RNA binding site [nucleotide binding]; other site 521098007755 adenylate kinase; Reviewed; Region: adk; PRK00279 521098007756 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 521098007757 AMP-binding site [chemical binding]; other site 521098007758 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 521098007759 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 521098007760 SecY translocase; Region: SecY; pfam00344 521098007761 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 521098007762 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 521098007763 23S rRNA binding site [nucleotide binding]; other site 521098007764 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 521098007765 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 521098007766 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 521098007767 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 521098007768 23S rRNA interface [nucleotide binding]; other site 521098007769 5S rRNA interface [nucleotide binding]; other site 521098007770 L27 interface [polypeptide binding]; other site 521098007771 L5 interface [polypeptide binding]; other site 521098007772 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 521098007773 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 521098007774 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 521098007775 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 521098007776 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 521098007777 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 521098007778 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 521098007779 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 521098007780 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 521098007781 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 521098007782 RNA binding site [nucleotide binding]; other site 521098007783 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 521098007784 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 521098007785 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 521098007786 23S rRNA interface [nucleotide binding]; other site 521098007787 putative translocon interaction site; other site 521098007788 signal recognition particle (SRP54) interaction site; other site 521098007789 L23 interface [polypeptide binding]; other site 521098007790 trigger factor interaction site; other site 521098007791 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 521098007792 23S rRNA interface [nucleotide binding]; other site 521098007793 5S rRNA interface [nucleotide binding]; other site 521098007794 putative antibiotic binding site [chemical binding]; other site 521098007795 L25 interface [polypeptide binding]; other site 521098007796 L27 interface [polypeptide binding]; other site 521098007797 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 521098007798 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 521098007799 G-X-X-G motif; other site 521098007800 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 521098007801 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 521098007802 putative translocon binding site; other site 521098007803 protein-rRNA interface [nucleotide binding]; other site 521098007804 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 521098007805 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 521098007806 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 521098007807 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 521098007808 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 521098007809 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 521098007810 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 521098007811 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 521098007812 elongation factor Tu; Reviewed; Region: PRK00049 521098007813 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 521098007814 G1 box; other site 521098007815 GEF interaction site [polypeptide binding]; other site 521098007816 GTP/Mg2+ binding site [chemical binding]; other site 521098007817 Switch I region; other site 521098007818 G2 box; other site 521098007819 G3 box; other site 521098007820 Switch II region; other site 521098007821 G4 box; other site 521098007822 G5 box; other site 521098007823 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 521098007824 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 521098007825 Antibiotic Binding Site [chemical binding]; other site 521098007826 elongation factor G; Reviewed; Region: PRK00007 521098007827 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 521098007828 G1 box; other site 521098007829 putative GEF interaction site [polypeptide binding]; other site 521098007830 GTP/Mg2+ binding site [chemical binding]; other site 521098007831 Switch I region; other site 521098007832 G2 box; other site 521098007833 G3 box; other site 521098007834 Switch II region; other site 521098007835 G4 box; other site 521098007836 G5 box; other site 521098007837 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 521098007838 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 521098007839 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 521098007840 30S ribosomal protein S7; Validated; Region: PRK05302 521098007841 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 521098007842 S17 interaction site [polypeptide binding]; other site 521098007843 S8 interaction site; other site 521098007844 16S rRNA interaction site [nucleotide binding]; other site 521098007845 streptomycin interaction site [chemical binding]; other site 521098007846 23S rRNA interaction site [nucleotide binding]; other site 521098007847 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 521098007848 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 521098007849 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 521098007850 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 521098007851 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 521098007852 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 521098007853 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 521098007854 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 521098007855 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 521098007856 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 521098007857 G-loop; other site 521098007858 DNA binding site [nucleotide binding] 521098007859 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 521098007860 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 521098007861 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 521098007862 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 521098007863 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 521098007864 RPB10 interaction site [polypeptide binding]; other site 521098007865 RPB1 interaction site [polypeptide binding]; other site 521098007866 RPB11 interaction site [polypeptide binding]; other site 521098007867 RPB3 interaction site [polypeptide binding]; other site 521098007868 RPB12 interaction site [polypeptide binding]; other site 521098007869 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 521098007870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098007871 S-adenosylmethionine binding site [chemical binding]; other site 521098007872 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 521098007873 core dimer interface [polypeptide binding]; other site 521098007874 peripheral dimer interface [polypeptide binding]; other site 521098007875 L10 interface [polypeptide binding]; other site 521098007876 L11 interface [polypeptide binding]; other site 521098007877 putative EF-Tu interaction site [polypeptide binding]; other site 521098007878 putative EF-G interaction site [polypeptide binding]; other site 521098007879 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 521098007880 23S rRNA interface [nucleotide binding]; other site 521098007881 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 521098007882 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 521098007883 mRNA/rRNA interface [nucleotide binding]; other site 521098007884 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 521098007885 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 521098007886 putative thiostrepton binding site; other site 521098007887 23S rRNA interface [nucleotide binding]; other site 521098007888 L7/L12 interface [polypeptide binding]; other site 521098007889 L25 interface [polypeptide binding]; other site 521098007890 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 521098007891 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 521098007892 putative homodimer interface [polypeptide binding]; other site 521098007893 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 521098007894 heterodimer interface [polypeptide binding]; other site 521098007895 homodimer interface [polypeptide binding]; other site 521098007896 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 521098007897 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 521098007898 RNA polymerase factor sigma-70; Validated; Region: PRK08295 521098007899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521098007900 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 521098007901 YacP-like NYN domain; Region: NYN_YacP; pfam05991 521098007902 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 521098007903 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 521098007904 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 521098007905 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 521098007906 active site 521098007907 metal binding site [ion binding]; metal-binding site 521098007908 dimerization interface [polypeptide binding]; other site 521098007909 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 521098007910 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 521098007911 active site 521098007912 HIGH motif; other site 521098007913 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 521098007914 KMSKS motif; other site 521098007915 tRNA binding surface [nucleotide binding]; other site 521098007916 anticodon binding site; other site 521098007917 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 521098007918 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 521098007919 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 521098007920 HIGH motif; other site 521098007921 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 521098007922 active site 521098007923 KMSKS motif; other site 521098007924 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 521098007925 homotrimer interaction site [polypeptide binding]; other site 521098007926 zinc binding site [ion binding]; other site 521098007927 CDP-binding sites; other site 521098007928 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 521098007929 substrate binding site; other site 521098007930 dimer interface; other site 521098007931 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 521098007932 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 521098007933 putative active site [active] 521098007934 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 521098007935 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 521098007936 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 521098007937 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 521098007938 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 521098007939 DNA repair protein RadA; Provisional; Region: PRK11823 521098007940 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 521098007941 Walker A motif/ATP binding site; other site 521098007942 ATP binding site [chemical binding]; other site 521098007943 Walker B motif; other site 521098007944 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 521098007945 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 521098007946 Clp amino terminal domain; Region: Clp_N; pfam02861 521098007947 Clp amino terminal domain; Region: Clp_N; pfam02861 521098007948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098007949 Walker A motif; other site 521098007950 ATP binding site [chemical binding]; other site 521098007951 Walker B motif; other site 521098007952 arginine finger; other site 521098007953 UvrB/uvrC motif; Region: UVR; pfam02151 521098007954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098007955 Walker A motif; other site 521098007956 ATP binding site [chemical binding]; other site 521098007957 Walker B motif; other site 521098007958 arginine finger; other site 521098007959 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 521098007960 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 521098007961 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 521098007962 ADP binding site [chemical binding]; other site 521098007963 phosphagen binding site; other site 521098007964 substrate specificity loop; other site 521098007965 DNA photolyase; Region: DNA_photolyase; pfam00875 521098007966 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 521098007967 UvrB/uvrC motif; Region: UVR; pfam02151 521098007968 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 521098007969 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 521098007970 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 521098007971 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 521098007972 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 521098007973 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 521098007974 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 521098007975 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 521098007976 rod shape-determining protein Mbl; Provisional; Region: PRK13928 521098007977 MreB and similar proteins; Region: MreB_like; cd10225 521098007978 nucleotide binding site [chemical binding]; other site 521098007979 Mg binding site [ion binding]; other site 521098007980 putative protofilament interaction site [polypeptide binding]; other site 521098007981 RodZ interaction site [polypeptide binding]; other site 521098007982 Stage III sporulation protein D; Region: SpoIIID; pfam12116 521098007983 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 521098007984 Peptidase family M23; Region: Peptidase_M23; pfam01551 521098007985 Stage II sporulation protein; Region: SpoIID; pfam08486 521098007986 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 521098007987 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 521098007988 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 521098007989 hinge; other site 521098007990 active site 521098007991 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 521098007992 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 521098007993 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 521098007994 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 521098007995 gamma subunit interface [polypeptide binding]; other site 521098007996 epsilon subunit interface [polypeptide binding]; other site 521098007997 LBP interface [polypeptide binding]; other site 521098007998 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 521098007999 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 521098008000 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 521098008001 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 521098008002 alpha subunit interaction interface [polypeptide binding]; other site 521098008003 Walker A motif; other site 521098008004 ATP binding site [chemical binding]; other site 521098008005 Walker B motif; other site 521098008006 inhibitor binding site; inhibition site 521098008007 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 521098008008 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 521098008009 core domain interface [polypeptide binding]; other site 521098008010 delta subunit interface [polypeptide binding]; other site 521098008011 epsilon subunit interface [polypeptide binding]; other site 521098008012 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 521098008013 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 521098008014 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 521098008015 beta subunit interaction interface [polypeptide binding]; other site 521098008016 Walker A motif; other site 521098008017 ATP binding site [chemical binding]; other site 521098008018 Walker B motif; other site 521098008019 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 521098008020 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712 521098008021 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 521098008022 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 521098008023 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 521098008024 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 521098008025 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 521098008026 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 521098008027 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 521098008028 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 521098008029 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 521098008030 active site 521098008031 homodimer interface [polypeptide binding]; other site 521098008032 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521098008033 active site 521098008034 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 521098008035 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 521098008036 dimer interface [polypeptide binding]; other site 521098008037 active site 521098008038 glycine-pyridoxal phosphate binding site [chemical binding]; other site 521098008039 folate binding site [chemical binding]; other site 521098008040 hypothetical protein; Provisional; Region: PRK13690 521098008041 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 521098008042 Low molecular weight phosphatase family; Region: LMWPc; cd00115 521098008043 active site 521098008044 Predicted membrane protein [Function unknown]; Region: COG1971 521098008045 Domain of unknown function DUF; Region: DUF204; pfam02659 521098008046 Domain of unknown function DUF; Region: DUF204; pfam02659 521098008047 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 521098008048 NlpC/P60 family; Region: NLPC_P60; cl17555 521098008049 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 521098008050 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 521098008051 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 521098008052 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 521098008053 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 521098008054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098008055 S-adenosylmethionine binding site [chemical binding]; other site 521098008056 peptide chain release factor 1; Validated; Region: prfA; PRK00591 521098008057 This domain is found in peptide chain release factors; Region: PCRF; smart00937 521098008058 RF-1 domain; Region: RF-1; pfam00472 521098008059 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 521098008060 transcription termination factor Rho; Provisional; Region: rho; PRK09376 521098008061 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 521098008062 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 521098008063 RNA binding site [nucleotide binding]; other site 521098008064 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 521098008065 multimer interface [polypeptide binding]; other site 521098008066 Walker A motif; other site 521098008067 ATP binding site [chemical binding]; other site 521098008068 Walker B motif; other site 521098008069 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 521098008070 active site 521098008071 intersubunit interactions; other site 521098008072 catalytic residue [active] 521098008073 Response regulator receiver domain; Region: Response_reg; pfam00072 521098008074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098008075 active site 521098008076 phosphorylation site [posttranslational modification] 521098008077 intermolecular recognition site; other site 521098008078 dimerization interface [polypeptide binding]; other site 521098008079 CTP synthetase; Validated; Region: pyrG; PRK05380 521098008080 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 521098008081 Catalytic site [active] 521098008082 active site 521098008083 UTP binding site [chemical binding]; other site 521098008084 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 521098008085 active site 521098008086 putative oxyanion hole; other site 521098008087 catalytic triad [active] 521098008088 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 521098008089 enoyl-CoA hydratase; Provisional; Region: PRK07658 521098008090 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 521098008091 substrate binding site [chemical binding]; other site 521098008092 oxyanion hole (OAH) forming residues; other site 521098008093 trimer interface [polypeptide binding]; other site 521098008094 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 521098008095 putative active site [active] 521098008096 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 521098008097 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 521098008098 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 521098008099 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521098008100 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 521098008101 active site 521098008102 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 521098008103 agmatinase; Region: agmatinase; TIGR01230 521098008104 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 521098008105 putative active site [active] 521098008106 Mn binding site [ion binding]; other site 521098008107 spermidine synthase; Provisional; Region: PRK00811 521098008108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098008109 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 521098008110 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 521098008111 active site 521098008112 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 521098008113 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 521098008114 NAD(P) binding site [chemical binding]; other site 521098008115 Transglycosylase; Region: Transgly; pfam00912 521098008116 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 521098008117 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 521098008118 aspartate aminotransferase; Provisional; Region: PRK05764 521098008119 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521098008120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098008121 homodimer interface [polypeptide binding]; other site 521098008122 catalytic residue [active] 521098008123 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570 521098008124 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 521098008125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521098008126 FeS/SAM binding site; other site 521098008127 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 521098008128 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 521098008129 active site 521098008130 dimer interfaces [polypeptide binding]; other site 521098008131 catalytic residues [active] 521098008132 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 521098008133 proline aminopeptidase P II; Provisional; Region: PRK10879 521098008134 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 521098008135 active site 521098008136 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 521098008137 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521098008138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521098008139 Coenzyme A binding pocket [chemical binding]; other site 521098008140 Domain of unknown function DUF77; Region: DUF77; pfam01910 521098008141 D-galactonate transporter; Region: 2A0114; TIGR00893 521098008142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098008143 putative substrate translocation pore; other site 521098008144 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 521098008145 N- and C-terminal domain interface [polypeptide binding]; other site 521098008146 active site 521098008147 catalytic site [active] 521098008148 metal binding site [ion binding]; metal-binding site 521098008149 carbohydrate binding site [chemical binding]; other site 521098008150 ATP binding site [chemical binding]; other site 521098008151 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521098008152 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 521098008153 active site 521098008154 metal binding site [ion binding]; metal-binding site 521098008155 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 521098008156 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 521098008157 homodimer interface [polypeptide binding]; other site 521098008158 substrate-cofactor binding pocket; other site 521098008159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098008160 catalytic residue [active] 521098008161 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 521098008162 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 521098008163 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521098008164 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 521098008165 GTP cyclohydrolase I; Provisional; Region: PLN03044 521098008166 active site 521098008167 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 521098008168 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 521098008169 substrate binding pocket [chemical binding]; other site 521098008170 chain length determination region; other site 521098008171 substrate-Mg2+ binding site; other site 521098008172 catalytic residues [active] 521098008173 aspartate-rich region 1; other site 521098008174 active site lid residues [active] 521098008175 aspartate-rich region 2; other site 521098008176 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 521098008177 active site lid residues [active] 521098008178 substrate binding pocket [chemical binding]; other site 521098008179 catalytic residues [active] 521098008180 substrate-Mg2+ binding site; other site 521098008181 aspartate-rich region 1; other site 521098008182 aspartate-rich region 2; other site 521098008183 phytoene desaturase; Region: crtI_fam; TIGR02734 521098008184 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521098008185 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 521098008186 Cytochrome P450; Region: p450; cl12078 521098008187 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 521098008188 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 521098008189 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 521098008190 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521098008191 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 521098008192 DXD motif; other site 521098008193 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 521098008194 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 521098008195 Protein of unknown function DUF58; Region: DUF58; pfam01882 521098008196 cyanate hydratase; Validated; Region: PRK02866 521098008197 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 521098008198 oligomer interface [polypeptide binding]; other site 521098008199 active site 521098008200 DinB family; Region: DinB; cl17821 521098008201 DinB superfamily; Region: DinB_2; pfam12867 521098008202 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 521098008203 Phosphotransferase enzyme family; Region: APH; pfam01636 521098008204 active site 521098008205 substrate binding site [chemical binding]; other site 521098008206 ATP binding site [chemical binding]; other site 521098008207 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521098008208 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521098008209 DNA binding site [nucleotide binding] 521098008210 domain linker motif; other site 521098008211 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 521098008212 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 521098008213 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 521098008214 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 521098008215 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 521098008216 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 521098008217 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 521098008218 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 521098008219 active site 521098008220 trimer interface [polypeptide binding]; other site 521098008221 substrate binding site [chemical binding]; other site 521098008222 CoA binding site [chemical binding]; other site 521098008223 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 521098008224 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 521098008225 metal binding site [ion binding]; metal-binding site 521098008226 putative dimer interface [polypeptide binding]; other site 521098008227 aminotransferase A; Validated; Region: PRK07683 521098008228 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521098008229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098008230 homodimer interface [polypeptide binding]; other site 521098008231 catalytic residue [active] 521098008232 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 521098008233 polypeptide substrate binding site [polypeptide binding]; other site 521098008234 active site 521098008235 H+ Antiporter protein; Region: 2A0121; TIGR00900 521098008236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098008237 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 521098008238 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 521098008239 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 521098008240 NAD(P) binding pocket [chemical binding]; other site 521098008241 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 521098008242 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 521098008243 Walker A/P-loop; other site 521098008244 ATP binding site [chemical binding]; other site 521098008245 Q-loop/lid; other site 521098008246 ABC transporter signature motif; other site 521098008247 Walker B; other site 521098008248 D-loop; other site 521098008249 H-loop/switch region; other site 521098008250 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 521098008251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098008252 dimer interface [polypeptide binding]; other site 521098008253 conserved gate region; other site 521098008254 putative PBP binding loops; other site 521098008255 ABC-ATPase subunit interface; other site 521098008256 sulfate transport protein; Provisional; Region: cysT; CHL00187 521098008257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098008258 dimer interface [polypeptide binding]; other site 521098008259 conserved gate region; other site 521098008260 putative PBP binding loops; other site 521098008261 ABC-ATPase subunit interface; other site 521098008262 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 521098008263 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 521098008264 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521098008265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521098008266 Walker A/P-loop; other site 521098008267 ATP binding site [chemical binding]; other site 521098008268 Q-loop/lid; other site 521098008269 ABC transporter signature motif; other site 521098008270 Walker B; other site 521098008271 D-loop; other site 521098008272 H-loop/switch region; other site 521098008273 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 521098008274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098008275 dimer interface [polypeptide binding]; other site 521098008276 conserved gate region; other site 521098008277 putative PBP binding loops; other site 521098008278 ABC-ATPase subunit interface; other site 521098008279 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 521098008280 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 521098008281 active site 521098008282 dimer interface [polypeptide binding]; other site 521098008283 non-prolyl cis peptide bond; other site 521098008284 insertion regions; other site 521098008285 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 521098008286 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 521098008287 substrate binding pocket [chemical binding]; other site 521098008288 membrane-bound complex binding site; other site 521098008289 hinge residues; other site 521098008290 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 521098008291 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 521098008292 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 521098008293 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 521098008294 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 521098008295 DNA binding residues [nucleotide binding] 521098008296 putative dimer interface [polypeptide binding]; other site 521098008297 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 521098008298 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 521098008299 active site 521098008300 biotin synthase; Validated; Region: PRK06256 521098008301 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 521098008302 AAA domain; Region: AAA_26; pfam13500 521098008303 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 521098008304 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 521098008305 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 521098008306 substrate-cofactor binding pocket; other site 521098008307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098008308 catalytic residue [active] 521098008309 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 521098008310 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 521098008311 inhibitor-cofactor binding pocket; inhibition site 521098008312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521098008313 catalytic residue [active] 521098008314 hypothetical protein; Provisional; Region: PRK06753 521098008315 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 521098008316 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 521098008317 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 521098008318 Walker A/P-loop; other site 521098008319 ATP binding site [chemical binding]; other site 521098008320 Q-loop/lid; other site 521098008321 ABC transporter signature motif; other site 521098008322 Walker B; other site 521098008323 D-loop; other site 521098008324 H-loop/switch region; other site 521098008325 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 521098008326 Prostaglandin dehydrogenases; Region: PGDH; cd05288 521098008327 NAD(P) binding site [chemical binding]; other site 521098008328 substrate binding site [chemical binding]; other site 521098008329 dimer interface [polypeptide binding]; other site 521098008330 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 521098008331 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 521098008332 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 521098008333 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 521098008334 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 521098008335 L-asparaginase II; Region: Asparaginase_II; pfam06089 521098008336 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 521098008337 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 521098008338 metal binding site [ion binding]; metal-binding site 521098008339 active site 521098008340 I-site; other site 521098008341 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 521098008342 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 521098008343 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 521098008344 trimer interface [polypeptide binding]; other site 521098008345 active site 521098008346 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 521098008347 catalytic site [active] 521098008348 maltodextrin glucosidase; Provisional; Region: PRK10785 521098008349 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 521098008350 homodimer interface [polypeptide binding]; other site 521098008351 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 521098008352 active site 521098008353 homodimer interface [polypeptide binding]; other site 521098008354 catalytic site [active] 521098008355 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521098008356 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521098008357 DNA binding site [nucleotide binding] 521098008358 domain linker motif; other site 521098008359 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 521098008360 putative dimerization interface [polypeptide binding]; other site 521098008361 putative ligand binding site [chemical binding]; other site 521098008362 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 521098008363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098008364 dimer interface [polypeptide binding]; other site 521098008365 conserved gate region; other site 521098008366 putative PBP binding loops; other site 521098008367 ABC-ATPase subunit interface; other site 521098008368 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 521098008369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521098008370 dimer interface [polypeptide binding]; other site 521098008371 conserved gate region; other site 521098008372 putative PBP binding loops; other site 521098008373 ABC-ATPase subunit interface; other site 521098008374 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 521098008375 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 521098008376 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 521098008377 homodimer interface [polypeptide binding]; other site 521098008378 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 521098008379 homodimer interface [polypeptide binding]; other site 521098008380 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 521098008381 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 521098008382 active site 521098008383 homodimer interface [polypeptide binding]; other site 521098008384 catalytic site [active] 521098008385 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 521098008386 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 521098008387 Pirin-related protein [General function prediction only]; Region: COG1741 521098008388 Pirin; Region: Pirin; pfam02678 521098008389 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 521098008390 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 521098008391 nudix motif; other site 521098008392 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521098008393 dimerization interface [polypeptide binding]; other site 521098008394 putative DNA binding site [nucleotide binding]; other site 521098008395 Transcriptional regulators [Transcription]; Region: MarR; COG1846 521098008396 putative Zn2+ binding site [ion binding]; other site 521098008397 phosphate:H+ symporter; Region: 2A0109; TIGR00887 521098008398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098008399 putative substrate translocation pore; other site 521098008400 Predicted membrane protein [Function unknown]; Region: COG3817 521098008401 Protein of unknown function (DUF979); Region: DUF979; pfam06166 521098008402 Protein of unknown function (DUF969); Region: DUF969; pfam06149 521098008403 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 521098008404 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 521098008405 putative catalytic cysteine [active] 521098008406 gamma-glutamyl kinase; Provisional; Region: PRK05429 521098008407 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 521098008408 homotetrameric interface [polypeptide binding]; other site 521098008409 putative phosphate binding site [ion binding]; other site 521098008410 putative allosteric binding site; other site 521098008411 nucleotide binding site [chemical binding]; other site 521098008412 PUA domain; Region: PUA; pfam01472 521098008413 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 521098008414 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 521098008415 putative alpha-glucosidase; Provisional; Region: PRK10658 521098008416 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 521098008417 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 521098008418 active site 521098008419 homotrimer interface [polypeptide binding]; other site 521098008420 catalytic site [active] 521098008421 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 521098008422 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 521098008423 Ligand Binding Site [chemical binding]; other site 521098008424 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 521098008425 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 521098008426 Cupin domain; Region: Cupin_2; pfam07883 521098008427 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 521098008428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521098008429 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521098008430 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 521098008431 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 521098008432 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 521098008433 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 521098008434 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 521098008435 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 521098008436 Nitrogen regulatory protein P-II; Region: P-II; smart00938 521098008437 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 521098008438 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 521098008439 Predicted transcriptional regulator [Transcription]; Region: COG4189 521098008440 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521098008441 dimerization interface [polypeptide binding]; other site 521098008442 putative DNA binding site [nucleotide binding]; other site 521098008443 putative Zn2+ binding site [ion binding]; other site 521098008444 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 521098008445 active site 521098008446 metal binding site [ion binding]; metal-binding site 521098008447 L-arabinose isomerase; Provisional; Region: PRK02929 521098008448 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 521098008449 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 521098008450 trimer interface [polypeptide binding]; other site 521098008451 putative substrate binding site [chemical binding]; other site 521098008452 putative metal binding site [ion binding]; other site 521098008453 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 521098008454 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 521098008455 intersubunit interface [polypeptide binding]; other site 521098008456 active site 521098008457 Zn2+ binding site [ion binding]; other site 521098008458 ribulokinase; Provisional; Region: PRK04123 521098008459 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 521098008460 N- and C-terminal domain interface [polypeptide binding]; other site 521098008461 active site 521098008462 MgATP binding site [chemical binding]; other site 521098008463 catalytic site [active] 521098008464 metal binding site [ion binding]; metal-binding site 521098008465 carbohydrate binding site [chemical binding]; other site 521098008466 homodimer interface [polypeptide binding]; other site 521098008467 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 521098008468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098008469 putative substrate translocation pore; other site 521098008470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098008471 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 521098008472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521098008473 DNA-binding site [nucleotide binding]; DNA binding site 521098008474 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 521098008475 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 521098008476 putative ligand binding site [chemical binding]; other site 521098008477 putative dimerization interface [polypeptide binding]; other site 521098008478 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 521098008479 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 521098008480 putative ligand binding site [chemical binding]; other site 521098008481 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 521098008482 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 521098008483 TM-ABC transporter signature motif; other site 521098008484 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 521098008485 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 521098008486 Walker A/P-loop; other site 521098008487 ATP binding site [chemical binding]; other site 521098008488 Q-loop/lid; other site 521098008489 ABC transporter signature motif; other site 521098008490 Walker B; other site 521098008491 D-loop; other site 521098008492 H-loop/switch region; other site 521098008493 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 521098008494 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 521098008495 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521098008496 DNA-binding site [nucleotide binding]; DNA binding site 521098008497 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 521098008498 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 521098008499 putative ligand binding site [chemical binding]; other site 521098008500 putative dimerization interface [polypeptide binding]; other site 521098008501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098008502 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521098008503 putative substrate translocation pore; other site 521098008504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 521098008505 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 521098008506 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 521098008507 dimer interface [polypeptide binding]; other site 521098008508 FMN binding site [chemical binding]; other site 521098008509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098008510 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 521098008511 putative substrate translocation pore; other site 521098008512 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 521098008513 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 521098008514 E3 interaction surface; other site 521098008515 lipoyl attachment site [posttranslational modification]; other site 521098008516 HlyD family secretion protein; Region: HlyD_3; pfam13437 521098008517 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521098008518 HSP70 interaction site [polypeptide binding]; other site 521098008519 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 521098008520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521098008521 NAD(P) binding site [chemical binding]; other site 521098008522 active site 521098008523 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 521098008524 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cd09299 521098008525 gating phenylalanine in ion channel; other site 521098008526 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 521098008527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 521098008528 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 521098008529 putative dimerization interface [polypeptide binding]; other site 521098008530 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 521098008531 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521098008532 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521098008533 protein binding site [polypeptide binding]; other site 521098008534 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 521098008535 YycH protein; Region: YycI; cl02015 521098008536 YycH protein; Region: YycH; pfam07435 521098008537 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 521098008538 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 521098008539 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 521098008540 dimerization interface [polypeptide binding]; other site 521098008541 PAS domain; Region: PAS; smart00091 521098008542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521098008543 dimer interface [polypeptide binding]; other site 521098008544 phosphorylation site [posttranslational modification] 521098008545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098008546 ATP binding site [chemical binding]; other site 521098008547 Mg2+ binding site [ion binding]; other site 521098008548 G-X-G motif; other site 521098008549 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521098008550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098008551 active site 521098008552 phosphorylation site [posttranslational modification] 521098008553 intermolecular recognition site; other site 521098008554 dimerization interface [polypeptide binding]; other site 521098008555 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521098008556 DNA binding site [nucleotide binding] 521098008557 replicative DNA helicase; Region: DnaB; TIGR00665 521098008558 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 521098008559 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 521098008560 Walker A motif; other site 521098008561 ATP binding site [chemical binding]; other site 521098008562 Walker B motif; other site 521098008563 DNA binding loops [nucleotide binding] 521098008564 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 521098008565 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 521098008566 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 521098008567 MazG-like family; Region: MazG-like; pfam12643 521098008568 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 521098008569 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 521098008570 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 521098008571 dimer interface [polypeptide binding]; other site 521098008572 ssDNA binding site [nucleotide binding]; other site 521098008573 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521098008574 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 521098008575 GTP-binding protein YchF; Reviewed; Region: PRK09601 521098008576 YchF GTPase; Region: YchF; cd01900 521098008577 G1 box; other site 521098008578 GTP/Mg2+ binding site [chemical binding]; other site 521098008579 Switch I region; other site 521098008580 G2 box; other site 521098008581 Switch II region; other site 521098008582 G3 box; other site 521098008583 G4 box; other site 521098008584 G5 box; other site 521098008585 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 521098008586 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 521098008587 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 521098008588 putative [4Fe-4S] binding site [ion binding]; other site 521098008589 putative molybdopterin cofactor binding site [chemical binding]; other site 521098008590 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 521098008591 molybdopterin cofactor binding site; other site 521098008592 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 521098008593 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 521098008594 Mechanosensitive ion channel; Region: MS_channel; pfam00924 521098008595 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 521098008596 Protein of unknown function (DUF554); Region: DUF554; pfam04474 521098008597 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 521098008598 ParB-like nuclease domain; Region: ParBc; pfam02195 521098008599 KorB domain; Region: KorB; pfam08535 521098008600 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521098008601 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521098008602 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 521098008603 ParB-like nuclease domain; Region: ParB; smart00470 521098008604 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 521098008605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098008606 S-adenosylmethionine binding site [chemical binding]; other site 521098008607 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 521098008608 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 521098008609 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 521098008610 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 521098008611 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 521098008612 trmE is a tRNA modification GTPase; Region: trmE; cd04164 521098008613 G1 box; other site 521098008614 GTP/Mg2+ binding site [chemical binding]; other site 521098008615 Switch I region; other site 521098008616 G2 box; other site 521098008617 Switch II region; other site 521098008618 G3 box; other site 521098008619 G4 box; other site 521098008620 G5 box; other site 521098008621 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 521098008622 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 521098008623 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 521098008624 G-X-X-G motif; other site 521098008625 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 521098008626 RxxxH motif; other site 521098008627 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 521098008628 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 521098008629 Haemolytic domain; Region: Haemolytic; pfam01809 521098008630 ribonuclease P; Reviewed; Region: rnpA; PRK00499 521098008631 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 521098008632 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 521098008633 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521098008634 putative DNA binding site [nucleotide binding]; other site 521098008635 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521098008636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098008637 non-specific DNA binding site [nucleotide binding]; other site 521098008638 salt bridge; other site 521098008639 sequence-specific DNA binding site [nucleotide binding]; other site 521098008640 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 521098008641 Catalytic site [active] 521098008642 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 521098008643 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 521098008644 Walker A motif; other site 521098008645 ATP binding site [chemical binding]; other site 521098008646 Walker B motif; other site 521098008647 AAA domain; Region: AAA_31; pfam13614 521098008648 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 521098008649 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 521098008650 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 521098008651 N-acetyl-D-glucosamine binding site [chemical binding]; other site 521098008652 catalytic residue [active] 521098008653 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521098008654 Zn2+ binding site [ion binding]; other site 521098008655 Mg2+ binding site [ion binding]; other site 521098008656 Short C-terminal domain; Region: SHOCT; pfam09851 521098008657 AAA-like domain; Region: AAA_10; pfam12846 521098008658 Domain of unknown function DUF87; Region: DUF87; pfam01935 521098008659 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521098008660 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521098008661 P-loop; other site 521098008662 Magnesium ion binding site [ion binding]; other site 521098008663 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521098008664 Magnesium ion binding site [ion binding]; other site 521098008665 Helix-turn-helix domain; Region: HTH_36; pfam13730 521098008666 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 521098008667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 521098008668 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 521098008669 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 521098008670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 521098008671 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 521098008672 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 521098008673 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 521098008674 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 521098008675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098008676 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521098008677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521098008678 putative substrate translocation pore; other site 521098008679 Methyltransferase domain; Region: Methyltransf_31; pfam13847 521098008680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521098008681 S-adenosylmethionine binding site [chemical binding]; other site 521098008682 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 521098008683 B12 binding site [chemical binding]; other site 521098008684 Radical SAM superfamily; Region: Radical_SAM; pfam04055 521098008685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521098008686 FeS/SAM binding site; other site 521098008687 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521098008688 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 521098008689 G4 box; other site 521098008690 G5 box; other site 521098008691 Protein of unknown function (DUF2699); Region: DUF2699; pfam10919 521098008692 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 521098008693 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521098008694 Coenzyme A binding pocket [chemical binding]; other site 521098008695 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 521098008696 DNA binding site [nucleotide binding] 521098008697 dimer interface [polypeptide binding]; other site 521098008698 active site 521098008699 Int/Topo IB signature motif; other site 521098008700 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 521098008701 putative active site [active] 521098008702 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 521098008703 PcfJ-like protein; Region: PcfJ; pfam14284 521098008704 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 521098008705 MPN+ (JAMM) motif; other site 521098008706 Zinc-binding site [ion binding]; other site 521098008707 DNA polymerase III subunit beta; Validated; Region: PRK05643 521098008708 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 521098008709 putative DNA binding surface [nucleotide binding]; other site 521098008710 dimer interface [polypeptide binding]; other site 521098008711 beta-clamp/translesion DNA polymerase binding surface; other site 521098008712 beta-clamp/clamp loader binding surface; other site 521098008713 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521098008714 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 521098008715 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 521098008716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521098008717 Walker A/P-loop; other site 521098008718 ATP binding site [chemical binding]; other site 521098008719 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 521098008720 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 521098008721 dimer interface [polypeptide binding]; other site 521098008722 ssDNA binding site [nucleotide binding]; other site 521098008723 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521098008724 CHC2 zinc finger; Region: zf-CHC2; cl17510 521098008725 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 521098008726 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 521098008727 AAA-like domain; Region: AAA_10; pfam12846 521098008728 AAA-like domain; Region: AAA_10; pfam12846 521098008729 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 521098008730 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 521098008731 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 521098008732 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521098008733 ATP binding site [chemical binding]; other site 521098008734 putative Mg++ binding site [ion binding]; other site 521098008735 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521098008736 nucleotide binding region [chemical binding]; other site 521098008737 ATP-binding site [chemical binding]; other site 521098008738 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 521098008739 IHF dimer interface [polypeptide binding]; other site 521098008740 IHF - DNA interface [nucleotide binding]; other site 521098008741 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 521098008742 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 521098008743 Part of AAA domain; Region: AAA_19; pfam13245 521098008744 Family description; Region: UvrD_C_2; pfam13538 521098008745 DNA polymerase IV; Reviewed; Region: PRK03103 521098008746 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 521098008747 active site 521098008748 DNA binding site [nucleotide binding] 521098008749 YolD-like protein; Region: YolD; pfam08863 521098008750 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 521098008751 ParB-like nuclease domain; Region: ParB; smart00470 521098008752 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 521098008753 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521098008754 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098008755 non-specific DNA binding site [nucleotide binding]; other site 521098008756 salt bridge; other site 521098008757 sequence-specific DNA binding site [nucleotide binding]; other site 521098008758 plasmid segregation protein ParM; Provisional; Region: PRK13917 521098008759 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 521098008760 Mg binding site [ion binding]; other site 521098008761 nucleotide binding site [chemical binding]; other site 521098008762 putative protofilament interface [polypeptide binding]; other site 521098008763 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 521098008764 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 521098008765 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 521098008766 Helix-turn-helix domain; Region: HTH_36; pfam13730 521098008767 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521098008768 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 521098008769 DNA binding residues [nucleotide binding] 521098008770 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 521098008771 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 521098008772 Transposase [DNA replication, recombination, and repair]; Region: COG5421 521098008773 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 521098008774 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 521098008775 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 521098008776 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 521098008777 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 521098008778 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 521098008779 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 521098008780 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 521098008781 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 521098008782 Transposase [DNA replication, recombination, and repair]; Region: COG5421 521098008783 Transposase [DNA replication, recombination, and repair]; Region: COG5421 521098008784 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 521098008785 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 521098008786 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521098008787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521098008788 non-specific DNA binding site [nucleotide binding]; other site 521098008789 salt bridge; other site 521098008790 sequence-specific DNA binding site [nucleotide binding]; other site 521098008791 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 521098008792 AzlC protein; Region: AzlC; pfam03591 521098008793 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521098008794 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 521098008795 dimer interface [polypeptide binding]; other site 521098008796 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 521098008797 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 521098008798 Spore germination protein; Region: Spore_permease; cl17796 521098008799 Tetratricopeptide repeat; Region: TPR_12; pfam13424 521098008800 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 521098008801 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 521098008802 Response regulator receiver domain; Region: Response_reg; pfam00072 521098008803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521098008804 active site 521098008805 phosphorylation site [posttranslational modification] 521098008806 intermolecular recognition site; other site 521098008807 dimerization interface [polypeptide binding]; other site 521098008808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 521098008809 Histidine kinase; Region: HisKA_3; pfam07730 521098008810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521098008811 ATP binding site [chemical binding]; other site 521098008812 Mg2+ binding site [ion binding]; other site 521098008813 G-X-G motif; other site 521098008814 Tetratricopeptide repeat; Region: TPR_12; pfam13424 521098008815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521098008816 binding surface 521098008817 TPR motif; other site 521098008818 Tetratricopeptide repeat; Region: TPR_12; pfam13424 521098008819 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521098008820 Zn2+ binding site [ion binding]; other site 521098008821 Mg2+ binding site [ion binding]; other site 521098008822 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 521098008823 DNA methylase; Region: N6_N4_Mtase; pfam01555 521098008824 DNA methylase; Region: N6_N4_Mtase; pfam01555 521098008825 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 521098008826 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 521098008827 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521098008828 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 521098008829 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 521098008830 putative active site pocket [active] 521098008831 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 521098008832 putative active site pocket [active] 521098008833 putative catalytic residue [active] 521098008834 dimerization interface [polypeptide binding]; other site 521098008835 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 521098008836 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 521098008837 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 521098008838 active site 521098008839 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 521098008840 FOG: WD40-like repeat [Function unknown]; Region: COG1520 521098008841 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 521098008842 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 521098008843 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 521098008844 putative active site [active] 521098008845 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 521098008846 ParB-like nuclease domain; Region: ParB; smart00470 521098008847 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 521098008848 BRO family, N-terminal domain; Region: Bro-N; smart01040 521098008849 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 521098008850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521098008851 AAA-like domain; Region: AAA_10; pfam12846 521098008852 Walker A motif; other site 521098008853 ATP binding site [chemical binding]; other site 521098008854 arginine finger; other site 521098008855 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 521098008856 AAA domain; Region: AAA_31; pfam13614 521098008857 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521098008858 P-loop; other site 521098008859 Magnesium ion binding site [ion binding]; other site 521098008860 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 521098008861 Type II/IV secretion system protein; Region: T2SE; pfam00437 521098008862 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 521098008863 Walker A motif; other site 521098008864 ATP binding site [chemical binding]; other site 521098008865 Walker B motif; other site 521098008866 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 521098008867 nucleotide binding site [chemical binding]; other site 521098008868 Transposase, Mutator family; Region: Transposase_mut; pfam00872 521098008869 MULE transposase domain; Region: MULE; pfam10551 521098008870 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 521098008871 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 521098008872 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521098008873 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 521098008874 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 521098008875 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 521098008876 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521098008877 P-loop; other site 521098008878 Magnesium ion binding site [ion binding]; other site 521098008879 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 521098008880 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 521098008881 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 521098008882 Walker A motif; other site 521098008883 ATP binding site [chemical binding]; other site 521098008884 Walker B motif; other site 521098008885 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 521098008886 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521098008887 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 521098008888 Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896 521098008889 D5 N terminal like; Region: D5_N; smart00885 521098008890 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 521098008891 Prophage antirepressor [Transcription]; Region: COG3617 521098008892 BRO family, N-terminal domain; Region: Bro-N; smart01040