-- dump date 20140618_193936 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1048834000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1048834000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1048834000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834000004 Walker A motif; other site 1048834000005 ATP binding site [chemical binding]; other site 1048834000006 Walker B motif; other site 1048834000007 arginine finger; other site 1048834000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1048834000009 DnaA box-binding interface [nucleotide binding]; other site 1048834000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1048834000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1048834000012 putative DNA binding surface [nucleotide binding]; other site 1048834000013 dimer interface [polypeptide binding]; other site 1048834000014 beta-clamp/clamp loader binding surface; other site 1048834000015 beta-clamp/translesion DNA polymerase binding surface; other site 1048834000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1048834000017 RNA binding surface [nucleotide binding]; other site 1048834000018 recombination protein F; Reviewed; Region: recF; PRK00064 1048834000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1048834000020 Walker A/P-loop; other site 1048834000021 ATP binding site [chemical binding]; other site 1048834000022 Q-loop/lid; other site 1048834000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834000024 ABC transporter signature motif; other site 1048834000025 Walker B; other site 1048834000026 D-loop; other site 1048834000027 H-loop/switch region; other site 1048834000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1048834000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834000030 ATP binding site [chemical binding]; other site 1048834000031 Mg2+ binding site [ion binding]; other site 1048834000032 G-X-G motif; other site 1048834000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1048834000034 anchoring element; other site 1048834000035 dimer interface [polypeptide binding]; other site 1048834000036 ATP binding site [chemical binding]; other site 1048834000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1048834000038 active site 1048834000039 putative metal-binding site [ion binding]; other site 1048834000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1048834000041 DNA gyrase subunit A; Validated; Region: PRK05560 1048834000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1048834000043 CAP-like domain; other site 1048834000044 active site 1048834000045 primary dimer interface [polypeptide binding]; other site 1048834000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1048834000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1048834000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1048834000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1048834000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1048834000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1048834000052 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1048834000053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1048834000054 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1048834000055 active site 1048834000056 catalytic motif [active] 1048834000057 Zn binding site [ion binding]; other site 1048834000058 MSP7-like protein C-terminal domain; Region: MSP7_C; pfam12948 1048834000059 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1048834000060 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1048834000061 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1048834000062 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1048834000063 active site 1048834000064 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1048834000065 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1048834000066 active site 1048834000067 multimer interface [polypeptide binding]; other site 1048834000068 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1048834000069 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 1048834000070 predicted active site [active] 1048834000071 catalytic triad [active] 1048834000072 seryl-tRNA synthetase; Provisional; Region: PRK05431 1048834000073 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1048834000074 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1048834000075 dimer interface [polypeptide binding]; other site 1048834000076 active site 1048834000077 motif 1; other site 1048834000078 motif 2; other site 1048834000079 motif 3; other site 1048834000080 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1048834000081 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 1048834000082 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834000083 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1048834000084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834000085 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1048834000086 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1048834000087 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1048834000088 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 1048834000089 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834000090 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1048834000091 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1048834000092 dimer interface [polypeptide binding]; other site 1048834000093 active site 1048834000094 CoA binding pocket [chemical binding]; other site 1048834000095 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1048834000096 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1048834000097 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1048834000098 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 1048834000099 TrkA-N domain; Region: TrkA_N; pfam02254 1048834000100 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1048834000101 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1048834000102 isocitrate lyase; Provisional; Region: PRK15063 1048834000103 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1048834000104 tetramer interface [polypeptide binding]; other site 1048834000105 active site 1048834000106 Mg2+/Mn2+ binding site [ion binding]; other site 1048834000107 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1048834000108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1048834000109 Probable transposase; Region: OrfB_IS605; pfam01385 1048834000110 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1048834000111 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1048834000112 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1048834000113 DNA binding residues [nucleotide binding] 1048834000114 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1048834000115 catalytic residues [active] 1048834000116 catalytic nucleophile [active] 1048834000117 H+ Antiporter protein; Region: 2A0121; TIGR00900 1048834000118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834000119 putative substrate translocation pore; other site 1048834000120 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048834000121 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1048834000122 TM-ABC transporter signature motif; other site 1048834000123 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048834000124 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1048834000125 TM-ABC transporter signature motif; other site 1048834000126 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1048834000127 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1048834000128 Walker A/P-loop; other site 1048834000129 ATP binding site [chemical binding]; other site 1048834000130 Q-loop/lid; other site 1048834000131 ABC transporter signature motif; other site 1048834000132 Walker B; other site 1048834000133 D-loop; other site 1048834000134 H-loop/switch region; other site 1048834000135 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1048834000136 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1048834000137 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1048834000138 ligand binding site [chemical binding]; other site 1048834000139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834000140 putative substrate translocation pore; other site 1048834000141 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1048834000142 Isochorismatase family; Region: Isochorismatase; pfam00857 1048834000143 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1048834000144 catalytic triad [active] 1048834000145 conserved cis-peptide bond; other site 1048834000146 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1048834000147 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1048834000148 active site 1048834000149 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1048834000150 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1048834000151 Walker A/P-loop; other site 1048834000152 ATP binding site [chemical binding]; other site 1048834000153 Q-loop/lid; other site 1048834000154 ABC transporter signature motif; other site 1048834000155 Walker B; other site 1048834000156 D-loop; other site 1048834000157 H-loop/switch region; other site 1048834000158 TOBE domain; Region: TOBE_2; pfam08402 1048834000159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834000160 dimer interface [polypeptide binding]; other site 1048834000161 conserved gate region; other site 1048834000162 putative PBP binding loops; other site 1048834000163 ABC-ATPase subunit interface; other site 1048834000164 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1048834000165 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1048834000166 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1048834000167 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1048834000168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834000169 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1048834000170 Walker A/P-loop; other site 1048834000171 ATP binding site [chemical binding]; other site 1048834000172 Q-loop/lid; other site 1048834000173 ABC transporter signature motif; other site 1048834000174 Walker B; other site 1048834000175 D-loop; other site 1048834000176 H-loop/switch region; other site 1048834000177 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1048834000178 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048834000179 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048834000180 active site 1048834000181 catalytic tetrad [active] 1048834000182 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048834000183 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048834000184 active site 1048834000185 catalytic tetrad [active] 1048834000186 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1048834000187 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048834000188 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1048834000189 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1048834000190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834000191 active site 1048834000192 phosphorylation site [posttranslational modification] 1048834000193 intermolecular recognition site; other site 1048834000194 dimerization interface [polypeptide binding]; other site 1048834000195 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048834000196 DNA binding site [nucleotide binding] 1048834000197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048834000198 dimer interface [polypeptide binding]; other site 1048834000199 phosphorylation site [posttranslational modification] 1048834000200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834000201 ATP binding site [chemical binding]; other site 1048834000202 Mg2+ binding site [ion binding]; other site 1048834000203 G-X-G motif; other site 1048834000204 LysE type translocator; Region: LysE; cl00565 1048834000205 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 1048834000206 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1048834000207 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1048834000208 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048834000209 DNA binding site [nucleotide binding] 1048834000210 domain linker motif; other site 1048834000211 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1048834000212 ligand binding site [chemical binding]; other site 1048834000213 dimerization interface [polypeptide binding]; other site 1048834000214 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 1048834000215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834000216 putative substrate translocation pore; other site 1048834000217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834000218 putative substrate translocation pore; other site 1048834000219 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1048834000220 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1048834000221 DNA binding residues [nucleotide binding] 1048834000222 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1048834000223 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 1048834000224 peptide binding site [polypeptide binding]; other site 1048834000225 dimer interface [polypeptide binding]; other site 1048834000226 Phosphate transporter family; Region: PHO4; pfam01384 1048834000227 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1048834000228 glycerol kinase; Provisional; Region: glpK; PRK00047 1048834000229 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1048834000230 N- and C-terminal domain interface [polypeptide binding]; other site 1048834000231 active site 1048834000232 MgATP binding site [chemical binding]; other site 1048834000233 catalytic site [active] 1048834000234 metal binding site [ion binding]; metal-binding site 1048834000235 glycerol binding site [chemical binding]; other site 1048834000236 homotetramer interface [polypeptide binding]; other site 1048834000237 homodimer interface [polypeptide binding]; other site 1048834000238 FBP binding site [chemical binding]; other site 1048834000239 protein IIAGlc interface [polypeptide binding]; other site 1048834000240 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1048834000241 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1048834000242 peptidase domain interface [polypeptide binding]; other site 1048834000243 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1048834000244 active site 1048834000245 catalytic triad [active] 1048834000246 calcium binding site [ion binding]; other site 1048834000247 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1048834000248 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048834000249 DNA-binding site [nucleotide binding]; DNA binding site 1048834000250 FCD domain; Region: FCD; pfam07729 1048834000251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048834000252 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1048834000253 NAD(P) binding site [chemical binding]; other site 1048834000254 active site 1048834000255 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 1048834000256 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 1048834000257 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 1048834000258 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1048834000259 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1048834000260 Na binding site [ion binding]; other site 1048834000261 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1048834000262 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1048834000263 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048834000264 putative active site [active] 1048834000265 heme pocket [chemical binding]; other site 1048834000266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048834000267 dimer interface [polypeptide binding]; other site 1048834000268 phosphorylation site [posttranslational modification] 1048834000269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834000270 ATP binding site [chemical binding]; other site 1048834000271 Mg2+ binding site [ion binding]; other site 1048834000272 G-X-G motif; other site 1048834000273 potential frameshift: common BLAST hit: gi|321312905|ref|YP_004205192.1| putative integral inner membrane protein 1048834000274 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1048834000275 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 1048834000276 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1048834000277 active site 1048834000278 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1048834000279 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1048834000280 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1048834000281 catalytic site [active] 1048834000282 G-X2-G-X-G-K; other site 1048834000283 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1048834000284 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048834000285 dimerization interface [polypeptide binding]; other site 1048834000286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048834000287 dimer interface [polypeptide binding]; other site 1048834000288 phosphorylation site [posttranslational modification] 1048834000289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834000290 ATP binding site [chemical binding]; other site 1048834000291 Mg2+ binding site [ion binding]; other site 1048834000292 G-X-G motif; other site 1048834000293 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1048834000294 short chain dehydrogenase; Provisional; Region: PRK06197 1048834000295 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1048834000296 putative NAD(P) binding site [chemical binding]; other site 1048834000297 active site 1048834000298 thymidine kinase; Provisional; Region: PRK04296 1048834000299 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 1048834000300 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1048834000301 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1048834000302 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1048834000303 PLD-like domain; Region: PLDc_2; pfam13091 1048834000304 putative active site [active] 1048834000305 catalytic site [active] 1048834000306 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128 1048834000307 PLD-like domain; Region: PLDc_2; pfam13091 1048834000308 putative active site [active] 1048834000309 putative catalytic site [active] 1048834000310 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 1048834000311 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1048834000312 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1048834000313 active site 1048834000314 catalytic site [active] 1048834000315 metal binding site [ion binding]; metal-binding site 1048834000316 dimer interface [polypeptide binding]; other site 1048834000317 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1048834000318 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1048834000319 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1048834000320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834000321 dimer interface [polypeptide binding]; other site 1048834000322 conserved gate region; other site 1048834000323 putative PBP binding loops; other site 1048834000324 ABC-ATPase subunit interface; other site 1048834000325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834000326 dimer interface [polypeptide binding]; other site 1048834000327 conserved gate region; other site 1048834000328 putative PBP binding loops; other site 1048834000329 ABC-ATPase subunit interface; other site 1048834000330 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1048834000331 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1048834000332 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1048834000333 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1048834000334 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1048834000335 putative substrate binding pocket [chemical binding]; other site 1048834000336 AC domain interface; other site 1048834000337 catalytic triad [active] 1048834000338 AB domain interface; other site 1048834000339 interchain disulfide; other site 1048834000340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1048834000341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048834000342 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1048834000343 Predicted membrane protein [Function unknown]; Region: COG1511 1048834000344 Predicted membrane protein [Function unknown]; Region: COG1511 1048834000345 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1048834000346 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1048834000347 Family description; Region: UvrD_C_2; pfam13538 1048834000348 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1048834000349 catalytic core [active] 1048834000350 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1048834000351 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1048834000352 active site 1048834000353 dimer interface [polypeptide binding]; other site 1048834000354 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1048834000355 dimer interface [polypeptide binding]; other site 1048834000356 active site 1048834000357 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1048834000358 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1048834000359 nucleotide binding site [chemical binding]; other site 1048834000360 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 1048834000361 MMPL family; Region: MMPL; pfam03176 1048834000362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1048834000363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048834000364 ARD/ARD' family; Region: ARD; pfam03079 1048834000365 Cupin domain; Region: Cupin_2; pfam07883 1048834000366 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1048834000367 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1048834000368 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 1048834000369 dimer interface [polypeptide binding]; other site 1048834000370 catalytic residue [active] 1048834000371 metal binding site [ion binding]; metal-binding site 1048834000372 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048834000373 motif II; other site 1048834000374 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1048834000375 intersubunit interface [polypeptide binding]; other site 1048834000376 active site 1048834000377 Zn2+ binding site [ion binding]; other site 1048834000378 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1048834000379 active site 1048834000380 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1048834000381 dimer interface [polypeptide binding]; other site 1048834000382 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1048834000383 Ligand Binding Site [chemical binding]; other site 1048834000384 Molecular Tunnel; other site 1048834000385 Late competence development protein ComFB; Region: ComFB; pfam10719 1048834000386 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1048834000387 nucleoside/Zn binding site; other site 1048834000388 dimer interface [polypeptide binding]; other site 1048834000389 catalytic motif [active] 1048834000390 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1048834000391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048834000392 dimer interface [polypeptide binding]; other site 1048834000393 phosphorylation site [posttranslational modification] 1048834000394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834000395 ATP binding site [chemical binding]; other site 1048834000396 Mg2+ binding site [ion binding]; other site 1048834000397 G-X-G motif; other site 1048834000398 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1048834000399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834000400 Walker A motif; other site 1048834000401 ATP binding site [chemical binding]; other site 1048834000402 Walker B motif; other site 1048834000403 arginine finger; other site 1048834000404 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1048834000405 hypothetical protein; Validated; Region: PRK00153 1048834000406 recombination protein RecR; Reviewed; Region: recR; PRK00076 1048834000407 RecR protein; Region: RecR; pfam02132 1048834000408 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1048834000409 putative active site [active] 1048834000410 putative metal-binding site [ion binding]; other site 1048834000411 tetramer interface [polypeptide binding]; other site 1048834000412 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1048834000413 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1048834000414 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 1048834000415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834000416 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048834000417 putative substrate translocation pore; other site 1048834000418 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1048834000419 active site 1048834000420 intersubunit interface [polypeptide binding]; other site 1048834000421 Zn2+ binding site [ion binding]; other site 1048834000422 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1048834000423 active site residue [active] 1048834000424 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1048834000425 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1048834000426 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048834000427 dimerization interface [polypeptide binding]; other site 1048834000428 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1048834000429 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1048834000430 dimer interface [polypeptide binding]; other site 1048834000431 putative CheW interface [polypeptide binding]; other site 1048834000432 Response regulator receiver domain; Region: Response_reg; pfam00072 1048834000433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834000434 active site 1048834000435 phosphorylation site [posttranslational modification] 1048834000436 intermolecular recognition site; other site 1048834000437 dimerization interface [polypeptide binding]; other site 1048834000438 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1048834000439 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1048834000440 heme-binding site [chemical binding]; other site 1048834000441 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1048834000442 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1048834000443 dimer interface [polypeptide binding]; other site 1048834000444 putative CheW interface [polypeptide binding]; other site 1048834000445 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1048834000446 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1048834000447 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1048834000448 putative binding surface; other site 1048834000449 active site 1048834000450 P2 response regulator binding domain; Region: P2; pfam07194 1048834000451 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1048834000452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834000453 ATP binding site [chemical binding]; other site 1048834000454 Mg2+ binding site [ion binding]; other site 1048834000455 G-X-G motif; other site 1048834000456 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1048834000457 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1048834000458 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1048834000459 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1048834000460 dimer interface [polypeptide binding]; other site 1048834000461 putative CheW interface [polypeptide binding]; other site 1048834000462 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1048834000463 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1048834000464 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1048834000465 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834000466 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1048834000467 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1048834000468 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1048834000469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834000470 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1048834000471 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1048834000472 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1048834000473 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1048834000474 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1048834000475 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1048834000476 catalytic residue [active] 1048834000477 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1048834000478 thymidylate kinase; Validated; Region: tmk; PRK00698 1048834000479 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1048834000480 TMP-binding site; other site 1048834000481 ATP-binding site [chemical binding]; other site 1048834000482 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1048834000483 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 1048834000484 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1048834000485 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1048834000486 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1048834000487 Predicted methyltransferases [General function prediction only]; Region: COG0313 1048834000488 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1048834000489 putative SAM binding site [chemical binding]; other site 1048834000490 putative homodimer interface [polypeptide binding]; other site 1048834000491 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1048834000492 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1048834000493 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1048834000494 active site 1048834000495 HIGH motif; other site 1048834000496 KMSKS motif; other site 1048834000497 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1048834000498 tRNA binding surface [nucleotide binding]; other site 1048834000499 anticodon binding site; other site 1048834000500 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1048834000501 dimer interface [polypeptide binding]; other site 1048834000502 putative tRNA-binding site [nucleotide binding]; other site 1048834000503 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1048834000504 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1048834000505 active site 1048834000506 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1048834000507 Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair]; Region: COG1658 1048834000508 active site 1048834000509 metal binding site [ion binding]; metal-binding site 1048834000510 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1048834000511 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1048834000512 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1048834000513 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1048834000514 active site 1048834000515 diiron metal binding site [ion binding]; other site 1048834000516 PGAP1-like protein; Region: PGAP1; pfam07819 1048834000517 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470 1048834000518 GAF domain; Region: GAF; pfam01590 1048834000519 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1048834000520 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048834000521 DNA binding residues [nucleotide binding] 1048834000522 dimerization interface [polypeptide binding]; other site 1048834000523 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1048834000524 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1048834000525 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1048834000526 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1048834000527 putative NAD(P) binding site [chemical binding]; other site 1048834000528 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1048834000529 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1048834000530 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1048834000531 acyl-activating enzyme (AAE) consensus motif; other site 1048834000532 putative AMP binding site [chemical binding]; other site 1048834000533 putative active site [active] 1048834000534 putative CoA binding site [chemical binding]; other site 1048834000535 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1048834000536 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1048834000537 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1048834000538 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1048834000539 active site 1048834000540 enoyl-CoA hydratase; Provisional; Region: PRK07657 1048834000541 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1048834000542 substrate binding site [chemical binding]; other site 1048834000543 oxyanion hole (OAH) forming residues; other site 1048834000544 trimer interface [polypeptide binding]; other site 1048834000545 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1048834000546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048834000547 NAD(P) binding site [chemical binding]; other site 1048834000548 active site 1048834000549 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1048834000550 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1048834000551 dimer interface [polypeptide binding]; other site 1048834000552 active site 1048834000553 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1048834000554 active site 1048834000555 catalytic site [active] 1048834000556 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1048834000557 ABC1 family; Region: ABC1; cl17513 1048834000558 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1048834000559 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1048834000560 NAD(P) binding site [chemical binding]; other site 1048834000561 catalytic residues [active] 1048834000562 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1048834000563 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 1048834000564 active site 1048834000565 metal binding site [ion binding]; metal-binding site 1048834000566 S-layer homology domain; Region: SLH; pfam00395 1048834000567 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1048834000568 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1048834000569 active site 1048834000570 glutamyl-tRNA synthetase; Provisional; Region: gltX; PRK04156 1048834000571 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1048834000572 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1048834000573 homotetramer interface [polypeptide binding]; other site 1048834000574 NAD(P) binding site [chemical binding]; other site 1048834000575 homodimer interface [polypeptide binding]; other site 1048834000576 active site 1048834000577 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1048834000578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048834000579 NAD(P) binding site [chemical binding]; other site 1048834000580 active site 1048834000581 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1048834000582 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1048834000583 FAD binding site [chemical binding]; other site 1048834000584 substrate binding site [chemical binding]; other site 1048834000585 catalytic base [active] 1048834000586 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1048834000587 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1048834000588 dimer interface [polypeptide binding]; other site 1048834000589 acyl-activating enzyme (AAE) consensus motif; other site 1048834000590 putative active site [active] 1048834000591 AMP binding site [chemical binding]; other site 1048834000592 putative CoA binding site [chemical binding]; other site 1048834000593 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1048834000594 active site 1048834000595 catalytic site [active] 1048834000596 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1048834000597 active site 2 [active] 1048834000598 active site 1 [active] 1048834000599 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1048834000600 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1048834000601 putative DNA binding site [nucleotide binding]; other site 1048834000602 putative Zn2+ binding site [ion binding]; other site 1048834000603 Bacterial transcriptional regulator; Region: IclR; pfam01614 1048834000604 Phosphotransferase enzyme family; Region: APH; pfam01636 1048834000605 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1048834000606 putative active site [active] 1048834000607 putative substrate binding site [chemical binding]; other site 1048834000608 ATP binding site [chemical binding]; other site 1048834000609 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1048834000610 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1048834000611 DNA binding site [nucleotide binding] 1048834000612 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1048834000613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834000614 Walker A/P-loop; other site 1048834000615 ATP binding site [chemical binding]; other site 1048834000616 Q-loop/lid; other site 1048834000617 ABC transporter signature motif; other site 1048834000618 Walker B; other site 1048834000619 D-loop; other site 1048834000620 H-loop/switch region; other site 1048834000621 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834000622 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1048834000623 MULE transposase domain; Region: MULE; pfam10551 1048834000624 Predicted permeases [General function prediction only]; Region: COG0679 1048834000625 potential frameshift: common BLAST hit: gi|258512276|ref|YP_003185710.1| transposase IS4 family protein 1048834000626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1048834000627 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834000628 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1048834000629 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1048834000630 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1048834000631 active site 1048834000632 metal binding site [ion binding]; metal-binding site 1048834000633 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1048834000634 YabG peptidase U57; Region: Peptidase_U57; pfam05582 1048834000635 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1048834000636 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1048834000637 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1048834000638 proposed catalytic triad [active] 1048834000639 active site nucleophile [active] 1048834000640 cyanophycin synthetase; Provisional; Region: PRK14016 1048834000641 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1048834000642 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1048834000643 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1048834000644 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1048834000645 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1048834000646 pur operon repressor; Provisional; Region: PRK09213 1048834000647 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1048834000648 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048834000649 active site 1048834000650 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1048834000651 homotrimer interaction site [polypeptide binding]; other site 1048834000652 putative active site [active] 1048834000653 regulatory protein SpoVG; Reviewed; Region: PRK13259 1048834000654 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1048834000655 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1048834000656 Substrate binding site; other site 1048834000657 Mg++ binding site; other site 1048834000658 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1048834000659 active site 1048834000660 substrate binding site [chemical binding]; other site 1048834000661 CoA binding site [chemical binding]; other site 1048834000662 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1048834000663 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1048834000664 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048834000665 active site 1048834000666 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1048834000667 putative active site [active] 1048834000668 catalytic residue [active] 1048834000669 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1048834000670 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1048834000671 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1048834000672 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048834000673 ATP binding site [chemical binding]; other site 1048834000674 putative Mg++ binding site [ion binding]; other site 1048834000675 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048834000676 nucleotide binding region [chemical binding]; other site 1048834000677 ATP-binding site [chemical binding]; other site 1048834000678 TRCF domain; Region: TRCF; pfam03461 1048834000679 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1048834000680 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1048834000681 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1048834000682 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1048834000683 putative SAM binding site [chemical binding]; other site 1048834000684 putative homodimer interface [polypeptide binding]; other site 1048834000685 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1048834000686 homodimer interface [polypeptide binding]; other site 1048834000687 metal binding site [ion binding]; metal-binding site 1048834000688 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1048834000689 homodimer interface [polypeptide binding]; other site 1048834000690 active site 1048834000691 putative chemical substrate binding site [chemical binding]; other site 1048834000692 metal binding site [ion binding]; metal-binding site 1048834000693 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1048834000694 IHF - DNA interface [nucleotide binding]; other site 1048834000695 IHF dimer interface [polypeptide binding]; other site 1048834000696 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1048834000697 RNA binding surface [nucleotide binding]; other site 1048834000698 YabP family; Region: YabP; cl06766 1048834000699 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 1048834000700 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1048834000701 Septum formation initiator; Region: DivIC; pfam04977 1048834000702 hypothetical protein; Provisional; Region: PRK08582 1048834000703 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1048834000704 RNA binding site [nucleotide binding]; other site 1048834000705 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1048834000706 catalytic motif [active] 1048834000707 Zn binding site [ion binding]; other site 1048834000708 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1048834000709 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1048834000710 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1048834000711 metal ion-dependent adhesion site (MIDAS); other site 1048834000712 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1048834000713 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1048834000714 active site 1048834000715 ATP binding site [chemical binding]; other site 1048834000716 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1048834000717 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1048834000718 Ligand Binding Site [chemical binding]; other site 1048834000719 TilS substrate binding domain; Region: TilS; pfam09179 1048834000720 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1048834000721 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048834000722 active site 1048834000723 FtsH Extracellular; Region: FtsH_ext; pfam06480 1048834000724 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1048834000725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834000726 Walker A motif; other site 1048834000727 ATP binding site [chemical binding]; other site 1048834000728 Walker B motif; other site 1048834000729 arginine finger; other site 1048834000730 Peptidase family M41; Region: Peptidase_M41; pfam01434 1048834000731 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1048834000732 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1048834000733 Zn2+ binding site [ion binding]; other site 1048834000734 Mg2+ binding site [ion binding]; other site 1048834000735 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1048834000736 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1048834000737 dimerization interface [polypeptide binding]; other site 1048834000738 domain crossover interface; other site 1048834000739 redox-dependent activation switch; other site 1048834000740 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1048834000741 dihydropteroate synthase; Region: DHPS; TIGR01496 1048834000742 substrate binding pocket [chemical binding]; other site 1048834000743 dimer interface [polypeptide binding]; other site 1048834000744 inhibitor binding site; inhibition site 1048834000745 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1048834000746 catalytic center binding site [active] 1048834000747 ATP binding site [chemical binding]; other site 1048834000748 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1048834000749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834000750 non-specific DNA binding site [nucleotide binding]; other site 1048834000751 salt bridge; other site 1048834000752 sequence-specific DNA binding site [nucleotide binding]; other site 1048834000753 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1048834000754 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1048834000755 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1048834000756 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1048834000757 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1048834000758 dimer interface [polypeptide binding]; other site 1048834000759 putative anticodon binding site; other site 1048834000760 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1048834000761 motif 1; other site 1048834000762 active site 1048834000763 motif 2; other site 1048834000764 motif 3; other site 1048834000765 DinB family; Region: DinB; cl17821 1048834000766 DinB superfamily; Region: DinB_2; pfam12867 1048834000767 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1048834000768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834000769 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048834000770 putative substrate translocation pore; other site 1048834000771 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1048834000772 EamA-like transporter family; Region: EamA; pfam00892 1048834000773 EamA-like transporter family; Region: EamA; pfam00892 1048834000774 VanZ like family; Region: VanZ; cl01971 1048834000775 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1048834000776 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1048834000777 putative NAD(P) binding site [chemical binding]; other site 1048834000778 putative active site [active] 1048834000779 aspartate aminotransferase; Provisional; Region: PRK07681 1048834000780 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048834000781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834000782 homodimer interface [polypeptide binding]; other site 1048834000783 catalytic residue [active] 1048834000784 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1048834000785 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1048834000786 active site 1048834000787 cosubstrate binding site; other site 1048834000788 substrate binding site [chemical binding]; other site 1048834000789 catalytic site [active] 1048834000790 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1048834000791 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1048834000792 NAD(P) binding site [chemical binding]; other site 1048834000793 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1048834000794 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1048834000795 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1048834000796 active site 1048834000797 P-loop; other site 1048834000798 phosphorylation site [posttranslational modification] 1048834000799 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1048834000800 HTH domain; Region: HTH_11; pfam08279 1048834000801 PRD domain; Region: PRD; pfam00874 1048834000802 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1048834000803 active site 1048834000804 P-loop; other site 1048834000805 phosphorylation site [posttranslational modification] 1048834000806 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1048834000807 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1048834000808 active site 1048834000809 phosphorylation site [posttranslational modification] 1048834000810 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1048834000811 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1048834000812 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1048834000813 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1048834000814 dimerization domain swap beta strand [polypeptide binding]; other site 1048834000815 regulatory protein interface [polypeptide binding]; other site 1048834000816 active site 1048834000817 regulatory phosphorylation site [posttranslational modification]; other site 1048834000818 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1048834000819 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1048834000820 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1048834000821 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1048834000822 RNA polymerase sigma factor; Provisional; Region: PRK12519 1048834000823 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048834000824 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048834000825 DNA binding residues [nucleotide binding] 1048834000826 Putative zinc-finger; Region: zf-HC2; pfam13490 1048834000827 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1048834000828 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1048834000829 Amidase; Region: Amidase; cl11426 1048834000830 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1048834000831 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1048834000832 Probable transposase; Region: OrfB_IS605; pfam01385 1048834000833 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1048834000834 Amidase; Region: Amidase; cl11426 1048834000835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834000836 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1048834000837 Walker A/P-loop; other site 1048834000838 ATP binding site [chemical binding]; other site 1048834000839 Q-loop/lid; other site 1048834000840 ABC transporter signature motif; other site 1048834000841 Walker B; other site 1048834000842 D-loop; other site 1048834000843 H-loop/switch region; other site 1048834000844 Cobalt transport protein; Region: CbiQ; cl00463 1048834000845 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1048834000846 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1048834000847 Walker A/P-loop; other site 1048834000848 ATP binding site [chemical binding]; other site 1048834000849 Q-loop/lid; other site 1048834000850 ABC transporter signature motif; other site 1048834000851 Walker B; other site 1048834000852 D-loop; other site 1048834000853 H-loop/switch region; other site 1048834000854 BioY family; Region: BioY; pfam02632 1048834000855 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048834000856 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048834000857 metal binding site [ion binding]; metal-binding site 1048834000858 active site 1048834000859 I-site; other site 1048834000860 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048834000861 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1048834000862 putative DNA binding site [nucleotide binding]; other site 1048834000863 putative Zn2+ binding site [ion binding]; other site 1048834000864 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1048834000865 active site residue [active] 1048834000866 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1048834000867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834000868 putative substrate translocation pore; other site 1048834000869 Tannase and feruloyl esterase; Region: Tannase; pfam07519 1048834000870 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1048834000871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048834000872 NAD(P) binding site [chemical binding]; other site 1048834000873 active site 1048834000874 CrcB-like protein; Region: CRCB; pfam02537 1048834000875 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1048834000876 Predicted membrane protein [Function unknown]; Region: COG2246 1048834000877 GtrA-like protein; Region: GtrA; pfam04138 1048834000878 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1048834000879 substrate binding site [chemical binding]; other site 1048834000880 THF binding site; other site 1048834000881 zinc-binding site [ion binding]; other site 1048834000882 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1048834000883 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1048834000884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048834000885 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1048834000886 dimerization interface [polypeptide binding]; other site 1048834000887 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1048834000888 peptidase domain interface [polypeptide binding]; other site 1048834000889 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1048834000890 active site 1048834000891 catalytic triad [active] 1048834000892 calcium binding site [ion binding]; other site 1048834000893 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1048834000894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834000895 active site 1048834000896 phosphorylation site [posttranslational modification] 1048834000897 intermolecular recognition site; other site 1048834000898 dimerization interface [polypeptide binding]; other site 1048834000899 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048834000900 DNA binding site [nucleotide binding] 1048834000901 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1048834000902 GAF domain; Region: GAF_2; pfam13185 1048834000903 GAF domain; Region: GAF_3; pfam13492 1048834000904 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1048834000905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048834000906 dimer interface [polypeptide binding]; other site 1048834000907 phosphorylation site [posttranslational modification] 1048834000908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834000909 ATP binding site [chemical binding]; other site 1048834000910 Mg2+ binding site [ion binding]; other site 1048834000911 G-X-G motif; other site 1048834000912 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1048834000913 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1048834000914 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1048834000915 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1048834000916 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1048834000917 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1048834000918 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1048834000919 Ligand Binding Site [chemical binding]; other site 1048834000920 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1048834000921 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1048834000922 Ligand Binding Site [chemical binding]; other site 1048834000923 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1048834000924 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1048834000925 NodB motif; other site 1048834000926 active site 1048834000927 catalytic site [active] 1048834000928 metal binding site [ion binding]; metal-binding site 1048834000929 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048834000930 active site 1048834000931 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048834000932 catalytic tetrad [active] 1048834000933 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1048834000934 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1048834000935 Influenza C non-structural protein (NS1); Region: Flu_C_NS1; pfam03506 1048834000936 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1048834000937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834000938 putative substrate translocation pore; other site 1048834000939 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1048834000940 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048834000941 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1048834000942 active site 1048834000943 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1048834000944 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1048834000945 putative ligand binding site [chemical binding]; other site 1048834000946 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1048834000947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834000948 Walker A/P-loop; other site 1048834000949 ATP binding site [chemical binding]; other site 1048834000950 Q-loop/lid; other site 1048834000951 ABC transporter signature motif; other site 1048834000952 Walker B; other site 1048834000953 D-loop; other site 1048834000954 H-loop/switch region; other site 1048834000955 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1048834000956 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1048834000957 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048834000958 TM-ABC transporter signature motif; other site 1048834000959 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1048834000960 2-isopropylmalate synthase; Validated; Region: PRK03739 1048834000961 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1048834000962 active site 1048834000963 catalytic residues [active] 1048834000964 metal binding site [ion binding]; metal-binding site 1048834000965 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1048834000966 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1048834000967 catalytic residues [active] 1048834000968 dimer interface [polypeptide binding]; other site 1048834000969 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1048834000970 nucleotide binding site/active site [active] 1048834000971 HIT family signature motif; other site 1048834000972 catalytic residue [active] 1048834000973 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1048834000974 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1048834000975 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1048834000976 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1048834000977 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1048834000978 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1048834000979 putative metal binding site; other site 1048834000980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1048834000981 TPR motif; other site 1048834000982 binding surface 1048834000983 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1048834000984 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1048834000985 Replication initiation factor; Region: Rep_trans; pfam02486 1048834000986 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1048834000987 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834000988 non-specific DNA binding site [nucleotide binding]; other site 1048834000989 salt bridge; other site 1048834000990 sequence-specific DNA binding site [nucleotide binding]; other site 1048834000991 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1048834000992 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1048834000993 active site 1048834000994 DNA binding site [nucleotide binding] 1048834000995 Int/Topo IB signature motif; other site 1048834000996 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1048834000997 Transposase domain (DUF772); Region: DUF772; pfam05598 1048834000998 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834000999 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1048834001000 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1048834001001 GAF domain; Region: GAF_3; pfam13492 1048834001002 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1048834001003 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1048834001004 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1048834001005 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834001006 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1048834001007 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1048834001008 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834001009 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1048834001010 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1048834001011 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1048834001012 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1048834001013 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048834001014 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1048834001015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834001016 putative substrate translocation pore; other site 1048834001017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834001018 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1048834001019 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048834001020 MarR family; Region: MarR; pfam01047 1048834001021 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1048834001022 Transposase domain (DUF772); Region: DUF772; pfam05598 1048834001023 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1048834001024 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048834001025 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1048834001026 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1048834001027 Walker A/P-loop; other site 1048834001028 ATP binding site [chemical binding]; other site 1048834001029 Q-loop/lid; other site 1048834001030 ABC transporter signature motif; other site 1048834001031 Walker B; other site 1048834001032 D-loop; other site 1048834001033 H-loop/switch region; other site 1048834001034 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1048834001035 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1048834001036 FtsX-like permease family; Region: FtsX; pfam02687 1048834001037 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1048834001038 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1048834001039 substrate binding site [chemical binding]; other site 1048834001040 dimer interface [polypeptide binding]; other site 1048834001041 ATP binding site [chemical binding]; other site 1048834001042 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1048834001043 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1048834001044 active site 1048834001045 metal binding site [ion binding]; metal-binding site 1048834001046 DNA binding site [nucleotide binding] 1048834001047 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1048834001048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834001049 AAA domain; Region: AAA_23; pfam13476 1048834001050 Walker A/P-loop; other site 1048834001051 ATP binding site [chemical binding]; other site 1048834001052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834001053 Q-loop/lid; other site 1048834001054 ABC transporter signature motif; other site 1048834001055 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1048834001056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834001057 Q-loop/lid; other site 1048834001058 ABC transporter signature motif; other site 1048834001059 Walker B; other site 1048834001060 D-loop; other site 1048834001061 H-loop/switch region; other site 1048834001062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834001063 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048834001064 putative substrate translocation pore; other site 1048834001065 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1048834001066 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1048834001067 metal-binding site [ion binding] 1048834001068 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1048834001069 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1048834001070 metal-binding site [ion binding] 1048834001071 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1048834001072 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1048834001073 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1048834001074 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1048834001075 acyl-activating enzyme (AAE) consensus motif; other site 1048834001076 AMP binding site [chemical binding]; other site 1048834001077 active site 1048834001078 CoA binding site [chemical binding]; other site 1048834001079 Putative zinc-finger; Region: zf-HC2; pfam13490 1048834001080 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1048834001081 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048834001082 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048834001083 DNA binding residues [nucleotide binding] 1048834001084 Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292 1048834001085 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1048834001086 Oxidoreductase molybdopterin binding domain; Region: Oxidored_molyb; pfam00174 1048834001087 Moco binding site; other site 1048834001088 metal coordination site [ion binding]; other site 1048834001089 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1048834001090 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1048834001091 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1048834001092 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1048834001093 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1048834001094 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1048834001095 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1048834001096 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1048834001097 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1048834001098 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1048834001099 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 1048834001100 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1048834001101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1048834001102 TPR repeat; Region: TPR_11; pfam13414 1048834001103 TPR motif; other site 1048834001104 binding surface 1048834001105 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1048834001106 tetramerization interface [polypeptide binding]; other site 1048834001107 active site 1048834001108 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 1048834001109 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1048834001110 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1048834001111 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1048834001112 catalytic motif [active] 1048834001113 Catalytic residue [active] 1048834001114 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1048834001115 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1048834001116 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1048834001117 Walker A motif; other site 1048834001118 ATP binding site [chemical binding]; other site 1048834001119 Walker B motif; other site 1048834001120 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1048834001121 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1048834001122 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1048834001123 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834001124 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1048834001125 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1048834001126 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1048834001127 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1048834001128 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1048834001129 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1048834001130 Walker A motif; other site 1048834001131 ATP binding site [chemical binding]; other site 1048834001132 Walker B motif; other site 1048834001133 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1048834001134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1048834001135 Probable transposase; Region: OrfB_IS605; pfam01385 1048834001136 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1048834001137 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1048834001138 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1048834001139 catalytic residues [active] 1048834001140 catalytic nucleophile [active] 1048834001141 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1048834001142 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1048834001143 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1048834001144 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1048834001145 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048834001146 ATP binding site [chemical binding]; other site 1048834001147 putative Mg++ binding site [ion binding]; other site 1048834001148 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048834001149 nucleotide binding region [chemical binding]; other site 1048834001150 ATP-binding site [chemical binding]; other site 1048834001151 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1048834001152 PAS fold; Region: PAS; pfam00989 1048834001153 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048834001154 putative active site [active] 1048834001155 heme pocket [chemical binding]; other site 1048834001156 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1048834001157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834001158 Walker A motif; other site 1048834001159 ATP binding site [chemical binding]; other site 1048834001160 Walker B motif; other site 1048834001161 arginine finger; other site 1048834001162 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1048834001163 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1048834001164 inhibitor-cofactor binding pocket; inhibition site 1048834001165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834001166 catalytic residue [active] 1048834001167 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1048834001168 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1048834001169 NAD(P) binding site [chemical binding]; other site 1048834001170 catalytic residues [active] 1048834001171 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1048834001172 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1048834001173 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1048834001174 active site 1048834001175 Arginase family; Region: Arginase; cd09989 1048834001176 agmatinase; Region: agmatinase; TIGR01230 1048834001177 active site 1048834001178 Mn binding site [ion binding]; other site 1048834001179 oligomer interface [polypeptide binding]; other site 1048834001180 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1048834001181 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1048834001182 inhibitor-cofactor binding pocket; inhibition site 1048834001183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834001184 catalytic residue [active] 1048834001185 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1048834001186 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1048834001187 Glutamate binding site [chemical binding]; other site 1048834001188 homodimer interface [polypeptide binding]; other site 1048834001189 NAD binding site [chemical binding]; other site 1048834001190 catalytic residues [active] 1048834001191 PAS fold; Region: PAS_4; pfam08448 1048834001192 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1048834001193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834001194 Walker A motif; other site 1048834001195 ATP binding site [chemical binding]; other site 1048834001196 Walker B motif; other site 1048834001197 arginine finger; other site 1048834001198 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1048834001199 S-methylmethionine transporter; Provisional; Region: PRK11387 1048834001200 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1048834001201 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1048834001202 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1048834001203 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048834001204 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1048834001205 Walker A/P-loop; other site 1048834001206 ATP binding site [chemical binding]; other site 1048834001207 Q-loop/lid; other site 1048834001208 ABC transporter signature motif; other site 1048834001209 Walker B; other site 1048834001210 D-loop; other site 1048834001211 H-loop/switch region; other site 1048834001212 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1048834001213 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048834001214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834001215 Walker A/P-loop; other site 1048834001216 ATP binding site [chemical binding]; other site 1048834001217 Q-loop/lid; other site 1048834001218 ABC transporter signature motif; other site 1048834001219 Walker B; other site 1048834001220 D-loop; other site 1048834001221 H-loop/switch region; other site 1048834001222 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1048834001223 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1048834001224 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1048834001225 short chain dehydrogenase; Provisional; Region: PRK06701 1048834001226 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1048834001227 NAD binding site [chemical binding]; other site 1048834001228 metal binding site [ion binding]; metal-binding site 1048834001229 active site 1048834001230 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048834001231 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1048834001232 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048834001233 Carboxylesterase family; Region: COesterase; pfam00135 1048834001234 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1048834001235 substrate binding pocket [chemical binding]; other site 1048834001236 catalytic triad [active] 1048834001237 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1048834001238 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1048834001239 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1048834001240 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1048834001241 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1048834001242 phosphate:H+ symporter; Region: 2A0109; TIGR00887 1048834001243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834001244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834001245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048834001246 DNA-binding site [nucleotide binding]; DNA binding site 1048834001247 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1048834001248 FCD domain; Region: FCD; pfam07729 1048834001249 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1048834001250 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1048834001251 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1048834001252 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1048834001253 NAD binding site [chemical binding]; other site 1048834001254 catalytic residues [active] 1048834001255 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 1048834001256 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1048834001257 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1048834001258 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 1048834001259 tetramer interface [polypeptide binding]; other site 1048834001260 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 1048834001261 tetramer interface [polypeptide binding]; other site 1048834001262 active site 1048834001263 metal binding site [ion binding]; metal-binding site 1048834001264 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1048834001265 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1048834001266 dimer interface [polypeptide binding]; other site 1048834001267 active site 1048834001268 catalytic residue [active] 1048834001269 MMPL family; Region: MMPL; pfam03176 1048834001270 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1048834001271 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1048834001272 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1048834001273 Transglycosylase; Region: Transgly; pfam00912 1048834001274 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1048834001275 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1048834001276 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1048834001277 Interdomain contacts; other site 1048834001278 Cytokine receptor motif; other site 1048834001279 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1048834001280 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1048834001281 active site 1048834001282 Cupin domain; Region: Cupin_2; cl17218 1048834001283 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1048834001284 catalytic residues [active] 1048834001285 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1048834001286 putative active site [active] 1048834001287 putative metal binding site [ion binding]; other site 1048834001288 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1048834001289 active site 1048834001290 Protein of unknown function (DUF429); Region: DUF429; cl12046 1048834001291 Membrane protein of unknown function; Region: DUF360; pfam04020 1048834001292 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1048834001293 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1048834001294 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1048834001295 putative substrate binding site [chemical binding]; other site 1048834001296 putative ATP binding site [chemical binding]; other site 1048834001297 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1048834001298 alanine racemase; Reviewed; Region: alr; PRK00053 1048834001299 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1048834001300 active site 1048834001301 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1048834001302 dimer interface [polypeptide binding]; other site 1048834001303 substrate binding site [chemical binding]; other site 1048834001304 catalytic residues [active] 1048834001305 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1048834001306 PemK-like protein; Region: PemK; pfam02452 1048834001307 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1048834001308 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1048834001309 homotetramer interface [polypeptide binding]; other site 1048834001310 ligand binding site [chemical binding]; other site 1048834001311 catalytic site [active] 1048834001312 NAD binding site [chemical binding]; other site 1048834001313 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048834001314 dimerization interface [polypeptide binding]; other site 1048834001315 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1048834001316 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1048834001317 Zn2+ binding site [ion binding]; other site 1048834001318 Mg2+ binding site [ion binding]; other site 1048834001319 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 1048834001320 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1048834001321 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1048834001322 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1048834001323 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1048834001324 thiamine monophosphate kinase; Provisional; Region: PRK05731 1048834001325 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1048834001326 ATP binding site [chemical binding]; other site 1048834001327 dimerization interface [polypeptide binding]; other site 1048834001328 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1048834001329 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1048834001330 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1048834001331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048834001332 Coenzyme A binding pocket [chemical binding]; other site 1048834001333 UGMP family protein; Validated; Region: PRK09604 1048834001334 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1048834001335 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1048834001336 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1048834001337 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1048834001338 ABC transporter; Region: ABC_tran_2; pfam12848 1048834001339 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1048834001340 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1048834001341 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1048834001342 active site 1048834001343 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1048834001344 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1048834001345 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1048834001346 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1048834001347 GTP binding site; other site 1048834001348 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 1048834001349 putative MPT binding site; other site 1048834001350 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1048834001351 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1048834001352 oligomerisation interface [polypeptide binding]; other site 1048834001353 mobile loop; other site 1048834001354 roof hairpin; other site 1048834001355 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1048834001356 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1048834001357 ring oligomerisation interface [polypeptide binding]; other site 1048834001358 ATP/Mg binding site [chemical binding]; other site 1048834001359 stacking interactions; other site 1048834001360 hinge regions; other site 1048834001361 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1048834001362 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1048834001363 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834001364 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1048834001365 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1048834001366 active site residue [active] 1048834001367 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1048834001368 active site residue [active] 1048834001369 PAS domain S-box; Region: sensory_box; TIGR00229 1048834001370 PAS domain; Region: PAS_8; pfam13188 1048834001371 putative active site [active] 1048834001372 heme pocket [chemical binding]; other site 1048834001373 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1048834001374 Histidine kinase; Region: HisKA_3; pfam07730 1048834001375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834001376 ATP binding site [chemical binding]; other site 1048834001377 Mg2+ binding site [ion binding]; other site 1048834001378 G-X-G motif; other site 1048834001379 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1048834001380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834001381 active site 1048834001382 phosphorylation site [posttranslational modification] 1048834001383 intermolecular recognition site; other site 1048834001384 dimerization interface [polypeptide binding]; other site 1048834001385 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048834001386 DNA binding residues [nucleotide binding] 1048834001387 dimerization interface [polypeptide binding]; other site 1048834001388 MoxR-like ATPases [General function prediction only]; Region: COG0714 1048834001389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834001390 Walker A motif; other site 1048834001391 ATP binding site [chemical binding]; other site 1048834001392 Walker B motif; other site 1048834001393 arginine finger; other site 1048834001394 Protein of unknown function DUF58; Region: DUF58; pfam01882 1048834001395 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1048834001396 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1048834001397 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1048834001398 GMP synthase; Reviewed; Region: guaA; PRK00074 1048834001399 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1048834001400 AMP/PPi binding site [chemical binding]; other site 1048834001401 candidate oxyanion hole; other site 1048834001402 catalytic triad [active] 1048834001403 potential glutamine specificity residues [chemical binding]; other site 1048834001404 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1048834001405 ATP Binding subdomain [chemical binding]; other site 1048834001406 Ligand Binding sites [chemical binding]; other site 1048834001407 Dimerization subdomain; other site 1048834001408 adenylosuccinate lyase; Provisional; Region: PRK07492 1048834001409 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1048834001410 tetramer interface [polypeptide binding]; other site 1048834001411 active site 1048834001412 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1048834001413 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1048834001414 ATP binding site [chemical binding]; other site 1048834001415 active site 1048834001416 substrate binding site [chemical binding]; other site 1048834001417 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1048834001418 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1048834001419 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1048834001420 putative active site [active] 1048834001421 catalytic triad [active] 1048834001422 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1048834001423 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1048834001424 dimerization interface [polypeptide binding]; other site 1048834001425 ATP binding site [chemical binding]; other site 1048834001426 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1048834001427 dimerization interface [polypeptide binding]; other site 1048834001428 ATP binding site [chemical binding]; other site 1048834001429 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 1048834001430 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1048834001431 active site 1048834001432 tetramer interface [polypeptide binding]; other site 1048834001433 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048834001434 active site 1048834001435 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1048834001436 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1048834001437 dimerization interface [polypeptide binding]; other site 1048834001438 putative ATP binding site [chemical binding]; other site 1048834001439 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1048834001440 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1048834001441 purine monophosphate binding site [chemical binding]; other site 1048834001442 dimer interface [polypeptide binding]; other site 1048834001443 putative catalytic residues [active] 1048834001444 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1048834001445 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1048834001446 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1048834001447 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1048834001448 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1048834001449 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1048834001450 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1048834001451 Triose-phosphate Transporter family; Region: TPT; pfam03151 1048834001452 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1048834001453 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1048834001454 metal binding site [ion binding]; metal-binding site 1048834001455 substrate binding pocket [chemical binding]; other site 1048834001456 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1048834001457 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 1048834001458 Walker A/P-loop; other site 1048834001459 ATP binding site [chemical binding]; other site 1048834001460 Q-loop/lid; other site 1048834001461 ABC transporter signature motif; other site 1048834001462 Walker B; other site 1048834001463 D-loop; other site 1048834001464 H-loop/switch region; other site 1048834001465 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1048834001466 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1048834001467 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1048834001468 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1048834001469 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1048834001470 flagellar motor protein MotS; Reviewed; Region: PRK06925 1048834001471 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1048834001472 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1048834001473 ligand binding site [chemical binding]; other site 1048834001474 excinuclease ABC subunit B; Provisional; Region: PRK05298 1048834001475 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048834001476 ATP binding site [chemical binding]; other site 1048834001477 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048834001478 nucleotide binding region [chemical binding]; other site 1048834001479 ATP-binding site [chemical binding]; other site 1048834001480 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1048834001481 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1048834001482 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1048834001483 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1048834001484 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1048834001485 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1048834001486 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1048834001487 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1048834001488 Hpr binding site; other site 1048834001489 active site 1048834001490 homohexamer subunit interaction site [polypeptide binding]; other site 1048834001491 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1048834001492 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1048834001493 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1048834001494 active site 1048834001495 HIGH motif; other site 1048834001496 KMSK motif region; other site 1048834001497 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1048834001498 tRNA binding surface [nucleotide binding]; other site 1048834001499 anticodon binding site; other site 1048834001500 TPR repeat; Region: TPR_11; pfam13414 1048834001501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1048834001502 binding surface 1048834001503 TPR motif; other site 1048834001504 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1048834001505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1048834001506 TPR motif; other site 1048834001507 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1048834001508 binding surface 1048834001509 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1048834001510 nudix motif; other site 1048834001511 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1048834001512 AAA domain; Region: AAA_18; pfam13238 1048834001513 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1048834001514 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1048834001515 phosphate binding site [ion binding]; other site 1048834001516 putative substrate binding pocket [chemical binding]; other site 1048834001517 dimer interface [polypeptide binding]; other site 1048834001518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1048834001519 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1048834001520 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1048834001521 regulatory protein interface [polypeptide binding]; other site 1048834001522 regulatory phosphorylation site [posttranslational modification]; other site 1048834001523 endonuclease III; Region: ENDO3c; smart00478 1048834001524 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1048834001525 minor groove reading motif; other site 1048834001526 helix-hairpin-helix signature motif; other site 1048834001527 substrate binding pocket [chemical binding]; other site 1048834001528 active site 1048834001529 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1048834001530 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1048834001531 DNA binding and oxoG recognition site [nucleotide binding] 1048834001532 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1048834001533 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1048834001534 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1048834001535 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1048834001536 HIGH motif; other site 1048834001537 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1048834001538 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1048834001539 active site 1048834001540 KMSKS motif; other site 1048834001541 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1048834001542 tRNA binding surface [nucleotide binding]; other site 1048834001543 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1048834001544 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048834001545 DNA-binding site [nucleotide binding]; DNA binding site 1048834001546 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1048834001547 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1048834001548 NAD(P) binding site [chemical binding]; other site 1048834001549 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1048834001550 Protein of unknown function (DUF402); Region: DUF402; pfam04167 1048834001551 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1048834001552 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1048834001553 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1048834001554 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048834001555 ATP binding site [chemical binding]; other site 1048834001556 putative Mg++ binding site [ion binding]; other site 1048834001557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048834001558 nucleotide binding region [chemical binding]; other site 1048834001559 ATP-binding site [chemical binding]; other site 1048834001560 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1048834001561 RNase_H superfamily; Region: RNase_H_2; pfam13482 1048834001562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1048834001563 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1048834001564 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1048834001565 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1048834001566 active site 1048834001567 metal binding site [ion binding]; metal-binding site 1048834001568 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1048834001569 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1048834001570 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1048834001571 minor groove reading motif; other site 1048834001572 helix-hairpin-helix signature motif; other site 1048834001573 substrate binding pocket [chemical binding]; other site 1048834001574 active site 1048834001575 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1048834001576 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 1048834001577 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1048834001578 Spore germination protein; Region: Spore_permease; cl17796 1048834001579 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1048834001580 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1048834001581 active site 1048834001582 NAD binding site [chemical binding]; other site 1048834001583 metal binding site [ion binding]; metal-binding site 1048834001584 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1048834001585 NAD(P) binding site [chemical binding]; other site 1048834001586 catalytic residues [active] 1048834001587 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1048834001588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834001589 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1048834001590 putative substrate translocation pore; other site 1048834001591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834001592 PAS domain S-box; Region: sensory_box; TIGR00229 1048834001593 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048834001594 putative active site [active] 1048834001595 heme pocket [chemical binding]; other site 1048834001596 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1048834001597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834001598 Walker A motif; other site 1048834001599 ATP binding site [chemical binding]; other site 1048834001600 Walker B motif; other site 1048834001601 arginine finger; other site 1048834001602 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1048834001603 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1048834001604 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 1048834001605 active site 1048834001606 acyl-activating enzyme (AAE) consensus motif; other site 1048834001607 putative CoA binding site [chemical binding]; other site 1048834001608 AMP binding site [chemical binding]; other site 1048834001609 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1048834001610 RNA/DNA hybrid binding site [nucleotide binding]; other site 1048834001611 active site 1048834001612 epoxyqueuosine reductase; Region: TIGR00276 1048834001613 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1048834001614 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1048834001615 DNA binding site [nucleotide binding] 1048834001616 active site 1048834001617 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1048834001618 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1048834001619 tartrate dehydrogenase; Provisional; Region: PRK08194 1048834001620 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1048834001621 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1048834001622 Bacterial transcriptional regulator; Region: IclR; pfam01614 1048834001623 Putative amidase domain; Region: Amidase_6; pfam12671 1048834001624 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1048834001625 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1048834001626 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1048834001627 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048834001628 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1048834001629 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1048834001630 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1048834001631 E3 interaction surface; other site 1048834001632 lipoyl attachment site [posttranslational modification]; other site 1048834001633 e3 binding domain; Region: E3_binding; pfam02817 1048834001634 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1048834001635 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1048834001636 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1048834001637 alpha subunit interface [polypeptide binding]; other site 1048834001638 TPP binding site [chemical binding]; other site 1048834001639 heterodimer interface [polypeptide binding]; other site 1048834001640 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1048834001641 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1048834001642 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1048834001643 TPP-binding site [chemical binding]; other site 1048834001644 heterodimer interface [polypeptide binding]; other site 1048834001645 tetramer interface [polypeptide binding]; other site 1048834001646 phosphorylation loop region [posttranslational modification] 1048834001647 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1048834001648 Putative esterase; Region: Esterase; pfam00756 1048834001649 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1048834001650 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1048834001651 substrate binding pocket [chemical binding]; other site 1048834001652 catalytic triad [active] 1048834001653 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1048834001654 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1048834001655 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1048834001656 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1048834001657 SpoVR like protein; Region: SpoVR; pfam04293 1048834001658 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1048834001659 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1048834001660 potential catalytic triad [active] 1048834001661 conserved cys residue [active] 1048834001662 UPF0126 domain; Region: UPF0126; pfam03458 1048834001663 Predicted membrane protein [Function unknown]; Region: COG2860 1048834001664 UPF0126 domain; Region: UPF0126; pfam03458 1048834001665 conserved hypothetical protein; Region: TIGR02328 1048834001666 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 1048834001667 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048834001668 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1048834001669 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1048834001670 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1048834001671 ligand-binding site [chemical binding]; other site 1048834001672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1048834001673 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1048834001674 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1048834001675 FMN binding site [chemical binding]; other site 1048834001676 dimer interface [polypeptide binding]; other site 1048834001677 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1048834001678 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1048834001679 hinge; other site 1048834001680 active site 1048834001681 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1048834001682 Protein export membrane protein; Region: SecD_SecF; cl14618 1048834001683 IncA protein; Region: IncA; pfam04156 1048834001684 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1048834001685 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1048834001686 Walker A/P-loop; other site 1048834001687 ATP binding site [chemical binding]; other site 1048834001688 Q-loop/lid; other site 1048834001689 ABC transporter signature motif; other site 1048834001690 Walker B; other site 1048834001691 D-loop; other site 1048834001692 H-loop/switch region; other site 1048834001693 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1048834001694 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1048834001695 Walker A/P-loop; other site 1048834001696 ATP binding site [chemical binding]; other site 1048834001697 Q-loop/lid; other site 1048834001698 ABC transporter signature motif; other site 1048834001699 Walker B; other site 1048834001700 D-loop; other site 1048834001701 H-loop/switch region; other site 1048834001702 Predicted transcriptional regulators [Transcription]; Region: COG1725 1048834001703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048834001704 DNA-binding site [nucleotide binding]; DNA binding site 1048834001705 ribonuclease Z; Region: RNase_Z; TIGR02651 1048834001706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834001707 putative substrate translocation pore; other site 1048834001708 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1048834001709 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1048834001710 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1048834001711 dimerization interface [polypeptide binding]; other site 1048834001712 putative DNA binding site [nucleotide binding]; other site 1048834001713 putative Zn2+ binding site [ion binding]; other site 1048834001714 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1048834001715 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1048834001716 TrkA-C domain; Region: TrkA_C; pfam02080 1048834001717 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1048834001718 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1048834001719 Walker A/P-loop; other site 1048834001720 ATP binding site [chemical binding]; other site 1048834001721 Q-loop/lid; other site 1048834001722 ABC transporter signature motif; other site 1048834001723 Walker B; other site 1048834001724 D-loop; other site 1048834001725 H-loop/switch region; other site 1048834001726 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1048834001727 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1048834001728 Histidine kinase; Region: HisKA_3; pfam07730 1048834001729 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1048834001730 ATP binding site [chemical binding]; other site 1048834001731 Mg2+ binding site [ion binding]; other site 1048834001732 G-X-G motif; other site 1048834001733 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1048834001734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834001735 active site 1048834001736 phosphorylation site [posttranslational modification] 1048834001737 intermolecular recognition site; other site 1048834001738 dimerization interface [polypeptide binding]; other site 1048834001739 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048834001740 DNA binding residues [nucleotide binding] 1048834001741 dimerization interface [polypeptide binding]; other site 1048834001742 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1048834001743 active site 1048834001744 metal binding site [ion binding]; metal-binding site 1048834001745 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1048834001746 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1048834001747 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1048834001748 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1048834001749 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1048834001750 D-pathway; other site 1048834001751 Putative ubiquinol binding site [chemical binding]; other site 1048834001752 Low-spin heme (heme b) binding site [chemical binding]; other site 1048834001753 Putative water exit pathway; other site 1048834001754 Binuclear center (heme o3/CuB) [ion binding]; other site 1048834001755 K-pathway; other site 1048834001756 Putative proton exit pathway; other site 1048834001757 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1048834001758 Subunit I/III interface [polypeptide binding]; other site 1048834001759 Subunit III/IV interface [polypeptide binding]; other site 1048834001760 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1048834001761 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1048834001762 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1048834001763 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1048834001764 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1048834001765 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1048834001766 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1048834001767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834001768 S-adenosylmethionine binding site [chemical binding]; other site 1048834001769 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1048834001770 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048834001771 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048834001772 active site 1048834001773 catalytic tetrad [active] 1048834001774 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1048834001775 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1048834001776 active site 1048834001777 NAD binding site [chemical binding]; other site 1048834001778 metal binding site [ion binding]; metal-binding site 1048834001779 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1048834001780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048834001781 NAD(P) binding site [chemical binding]; other site 1048834001782 active site 1048834001783 Protein of unknown function (DUF420); Region: DUF420; pfam04238 1048834001784 GtrA-like protein; Region: GtrA; pfam04138 1048834001785 GtrA-like protein; Region: GtrA; pfam04138 1048834001786 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1048834001787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834001788 active site 1048834001789 phosphorylation site [posttranslational modification] 1048834001790 intermolecular recognition site; other site 1048834001791 dimerization interface [polypeptide binding]; other site 1048834001792 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048834001793 DNA binding site [nucleotide binding] 1048834001794 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048834001795 dimerization interface [polypeptide binding]; other site 1048834001796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048834001797 dimer interface [polypeptide binding]; other site 1048834001798 phosphorylation site [posttranslational modification] 1048834001799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834001800 ATP binding site [chemical binding]; other site 1048834001801 Mg2+ binding site [ion binding]; other site 1048834001802 G-X-G motif; other site 1048834001803 classical (c) SDRs; Region: SDR_c; cd05233 1048834001804 NAD(P) binding site [chemical binding]; other site 1048834001805 active site 1048834001806 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1048834001807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1048834001808 Probable transposase; Region: OrfB_IS605; pfam01385 1048834001809 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1048834001810 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1048834001811 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1048834001812 catalytic residues [active] 1048834001813 catalytic nucleophile [active] 1048834001814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048834001815 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1048834001816 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1048834001817 putative active site [active] 1048834001818 metal binding site [ion binding]; metal-binding site 1048834001819 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1048834001820 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1048834001821 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1048834001822 Coenzyme A binding pocket [chemical binding]; other site 1048834001823 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1048834001824 Part of AAA domain; Region: AAA_19; pfam13245 1048834001825 Family description; Region: UvrD_C_2; pfam13538 1048834001826 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1048834001827 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1048834001828 nucleotide binding pocket [chemical binding]; other site 1048834001829 K-X-D-G motif; other site 1048834001830 catalytic site [active] 1048834001831 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1048834001832 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1048834001833 Helix-hairpin-helix motif; Region: HHH; pfam00633 1048834001834 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1048834001835 Dimer interface [polypeptide binding]; other site 1048834001836 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1048834001837 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1048834001838 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1048834001839 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1048834001840 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1048834001841 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1048834001842 GatB domain; Region: GatB_Yqey; smart00845 1048834001843 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1048834001844 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1048834001845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834001846 S-adenosylmethionine binding site [chemical binding]; other site 1048834001847 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1048834001848 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1048834001849 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1048834001850 DNA binding residues [nucleotide binding] 1048834001851 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1048834001852 catalytic residues [active] 1048834001853 catalytic nucleophile [active] 1048834001854 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1048834001855 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1048834001856 Probable transposase; Region: OrfB_IS605; pfam01385 1048834001857 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1048834001858 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1048834001859 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1048834001860 DNA binding site [nucleotide binding] 1048834001861 Membrane transport protein; Region: Mem_trans; cl09117 1048834001862 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1048834001863 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1048834001864 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1048834001865 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1048834001866 dimerization interface [polypeptide binding]; other site 1048834001867 DPS ferroxidase diiron center [ion binding]; other site 1048834001868 ion pore; other site 1048834001869 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1048834001870 N- and C-terminal domain interface [polypeptide binding]; other site 1048834001871 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1048834001872 active site 1048834001873 putative catalytic site [active] 1048834001874 metal binding site [ion binding]; metal-binding site 1048834001875 ATP binding site [chemical binding]; other site 1048834001876 carbohydrate binding site [chemical binding]; other site 1048834001877 short chain dehydrogenase; Validated; Region: PRK08324 1048834001878 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1048834001879 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 1048834001880 putative NAD(P) binding site [chemical binding]; other site 1048834001881 active site 1048834001882 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1048834001883 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1048834001884 ribulokinase; Provisional; Region: PRK04123 1048834001885 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1048834001886 N- and C-terminal domain interface [polypeptide binding]; other site 1048834001887 active site 1048834001888 MgATP binding site [chemical binding]; other site 1048834001889 catalytic site [active] 1048834001890 metal binding site [ion binding]; metal-binding site 1048834001891 carbohydrate binding site [chemical binding]; other site 1048834001892 homodimer interface [polypeptide binding]; other site 1048834001893 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1048834001894 Q-loop/lid; other site 1048834001895 ABC transporter signature motif; other site 1048834001896 Walker B; other site 1048834001897 D-loop; other site 1048834001898 H-loop/switch region; other site 1048834001899 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1048834001900 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1048834001901 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1048834001902 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048834001903 TM-ABC transporter signature motif; other site 1048834001904 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 1048834001905 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1048834001906 putative ligand binding site [chemical binding]; other site 1048834001907 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1048834001908 L-fucose isomerase; Provisional; Region: fucI; PRK10991 1048834001909 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1048834001910 trimer interface [polypeptide binding]; other site 1048834001911 substrate binding site [chemical binding]; other site 1048834001912 Mn binding site [ion binding]; other site 1048834001913 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1048834001914 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1048834001915 nucleotide binding site [chemical binding]; other site 1048834001916 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1048834001917 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1048834001918 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1048834001919 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1048834001920 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1048834001921 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1048834001922 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1048834001923 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1048834001924 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1048834001925 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1048834001926 Cysteine-rich domain; Region: CCG; pfam02754 1048834001927 Cysteine-rich domain; Region: CCG; pfam02754 1048834001928 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 1048834001929 Predicted membrane protein [Function unknown]; Region: COG2323 1048834001930 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 1048834001931 SpoVA protein; Region: SpoVA; cl04298 1048834001932 stage V sporulation protein AD; Provisional; Region: PRK12404 1048834001933 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 1048834001934 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1048834001935 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1048834001936 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1048834001937 catalytic triad [active] 1048834001938 catalytic triad [active] 1048834001939 oxyanion hole [active] 1048834001940 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1048834001941 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1048834001942 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1048834001943 active site 1048834001944 catalytic triad [active] 1048834001945 oxyanion hole [active] 1048834001946 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1048834001947 active site 1048834001948 catalytic triad [active] 1048834001949 oxyanion hole [active] 1048834001950 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1048834001951 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1048834001952 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1048834001953 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1048834001954 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 1048834001955 acyl-activating enzyme (AAE) consensus motif; other site 1048834001956 putative AMP binding site [chemical binding]; other site 1048834001957 putative active site [active] 1048834001958 putative CoA binding site [chemical binding]; other site 1048834001959 SurA N-terminal domain; Region: SurA_N_3; cl07813 1048834001960 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1048834001961 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1048834001962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834001963 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1048834001964 putative substrate translocation pore; other site 1048834001965 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1048834001966 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1048834001967 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1048834001968 active site 1048834001969 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1048834001970 substrate binding site [chemical binding]; other site 1048834001971 catalytic residues [active] 1048834001972 dimer interface [polypeptide binding]; other site 1048834001973 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1048834001974 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1048834001975 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1048834001976 manganese transport protein MntH; Reviewed; Region: PRK00701 1048834001977 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1048834001978 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1048834001979 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1048834001980 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 1048834001981 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1048834001982 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1048834001983 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1048834001984 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1048834001985 active site 1048834001986 catalytic motif [active] 1048834001987 Zn binding site [ion binding]; other site 1048834001988 oligoendopeptidase F; Region: pepF; TIGR00181 1048834001989 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1048834001990 active site 1048834001991 Zn binding site [ion binding]; other site 1048834001992 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048834001993 dimer interface [polypeptide binding]; other site 1048834001994 phosphorylation site [posttranslational modification] 1048834001995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834001996 ATP binding site [chemical binding]; other site 1048834001997 Mg2+ binding site [ion binding]; other site 1048834001998 G-X-G motif; other site 1048834001999 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1048834002000 Phosphoglycerate kinase; Region: PGK; pfam00162 1048834002001 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1048834002002 substrate binding site [chemical binding]; other site 1048834002003 hinge regions; other site 1048834002004 ADP binding site [chemical binding]; other site 1048834002005 catalytic site [active] 1048834002006 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1048834002007 triosephosphate isomerase; Provisional; Region: PRK14565 1048834002008 substrate binding site [chemical binding]; other site 1048834002009 dimer interface [polypeptide binding]; other site 1048834002010 catalytic triad [active] 1048834002011 phosphoglyceromutase; Provisional; Region: PRK05434 1048834002012 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1048834002013 enolase; Provisional; Region: eno; PRK00077 1048834002014 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1048834002015 dimer interface [polypeptide binding]; other site 1048834002016 metal binding site [ion binding]; metal-binding site 1048834002017 substrate binding pocket [chemical binding]; other site 1048834002018 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1048834002019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834002020 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1048834002021 putative substrate translocation pore; other site 1048834002022 ribonuclease R; Region: RNase_R; TIGR02063 1048834002023 VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358 1048834002024 RNB domain; Region: RNB; pfam00773 1048834002025 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1048834002026 RNA binding site [nucleotide binding]; other site 1048834002027 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1048834002028 SmpB-tmRNA interface; other site 1048834002029 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1048834002030 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1048834002031 NAD(P) binding site [chemical binding]; other site 1048834002032 catalytic residues [active] 1048834002033 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1048834002034 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1048834002035 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1048834002036 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1048834002037 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1048834002038 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1048834002039 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1048834002040 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1048834002041 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1048834002042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834002043 S-adenosylmethionine binding site [chemical binding]; other site 1048834002044 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1048834002045 peptidase domain interface [polypeptide binding]; other site 1048834002046 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1048834002047 active site 1048834002048 catalytic triad [active] 1048834002049 calcium binding site [ion binding]; other site 1048834002050 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1048834002051 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1048834002052 THF binding site; other site 1048834002053 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1048834002054 substrate binding site [chemical binding]; other site 1048834002055 THF binding site; other site 1048834002056 zinc-binding site [ion binding]; other site 1048834002057 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1048834002058 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1048834002059 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1048834002060 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1048834002061 Amino acid permease; Region: AA_permease_2; pfam13520 1048834002062 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1048834002063 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1048834002064 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1048834002065 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1048834002066 urea carboxylase; Region: urea_carbox; TIGR02712 1048834002067 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1048834002068 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1048834002069 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1048834002070 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1048834002071 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1048834002072 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1048834002073 carboxyltransferase (CT) interaction site; other site 1048834002074 biotinylation site [posttranslational modification]; other site 1048834002075 allophanate hydrolase; Provisional; Region: PRK08186 1048834002076 Amidase; Region: Amidase; cl11426 1048834002077 allophanate hydrolase; Provisional; Region: PRK08186 1048834002078 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1048834002079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834002080 dimer interface [polypeptide binding]; other site 1048834002081 conserved gate region; other site 1048834002082 putative PBP binding loops; other site 1048834002083 ABC-ATPase subunit interface; other site 1048834002084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834002085 dimer interface [polypeptide binding]; other site 1048834002086 conserved gate region; other site 1048834002087 putative PBP binding loops; other site 1048834002088 ABC-ATPase subunit interface; other site 1048834002089 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1048834002090 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1048834002091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834002092 H+ Antiporter protein; Region: 2A0121; TIGR00900 1048834002093 putative substrate translocation pore; other site 1048834002094 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1048834002095 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1048834002096 dimer interface [polypeptide binding]; other site 1048834002097 putative CheW interface [polypeptide binding]; other site 1048834002098 Cache domain; Region: Cache_1; pfam02743 1048834002099 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1048834002100 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1048834002101 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1048834002102 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1048834002103 Catalytic site [active] 1048834002104 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048834002105 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048834002106 active site 1048834002107 catalytic tetrad [active] 1048834002108 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1048834002109 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1048834002110 G1 box; other site 1048834002111 putative GEF interaction site [polypeptide binding]; other site 1048834002112 GTP/Mg2+ binding site [chemical binding]; other site 1048834002113 Switch I region; other site 1048834002114 G2 box; other site 1048834002115 G3 box; other site 1048834002116 Switch II region; other site 1048834002117 G4 box; other site 1048834002118 G5 box; other site 1048834002119 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1048834002120 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1048834002121 active site 1048834002122 Zn binding site [ion binding]; other site 1048834002123 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 1048834002124 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1048834002125 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1048834002126 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1048834002127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048834002128 NAD(P) binding site [chemical binding]; other site 1048834002129 active site 1048834002130 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1048834002131 Melibiase; Region: Melibiase; pfam02065 1048834002132 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1048834002133 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1048834002134 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1048834002135 nucleotide binding site [chemical binding]; other site 1048834002136 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1048834002137 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1048834002138 dimer interface [polypeptide binding]; other site 1048834002139 substrate binding site [chemical binding]; other site 1048834002140 metal binding site [ion binding]; metal-binding site 1048834002141 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1048834002142 Putative glucoamylase; Region: Glycoamylase; pfam10091 1048834002143 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 1048834002144 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1048834002145 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 1048834002146 benzoate transport; Region: 2A0115; TIGR00895 1048834002147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834002148 putative substrate translocation pore; other site 1048834002149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834002150 putative substrate translocation pore; other site 1048834002151 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1048834002152 dimer interface [polypeptide binding]; other site 1048834002153 Citrate synthase; Region: Citrate_synt; pfam00285 1048834002154 active site 1048834002155 oxalacetate/citrate binding site [chemical binding]; other site 1048834002156 citrylCoA binding site [chemical binding]; other site 1048834002157 coenzyme A binding site [chemical binding]; other site 1048834002158 catalytic triad [active] 1048834002159 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1048834002160 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1048834002161 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1048834002162 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1048834002163 tetramer interface [polypeptide binding]; other site 1048834002164 active site 1048834002165 Mg2+/Mn2+ binding site [ion binding]; other site 1048834002166 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1048834002167 tetramer interface [polypeptide binding]; other site 1048834002168 threonine dehydratase; Provisional; Region: PRK08198 1048834002169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834002170 catalytic residue [active] 1048834002171 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1048834002172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834002173 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1048834002174 Walker A motif; other site 1048834002175 ATP binding site [chemical binding]; other site 1048834002176 Walker B motif; other site 1048834002177 arginine finger; other site 1048834002178 endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382 1048834002179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834002180 Walker A motif; other site 1048834002181 ATP binding site [chemical binding]; other site 1048834002182 Walker B motif; other site 1048834002183 arginine finger; other site 1048834002184 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1048834002185 Flavoprotein; Region: Flavoprotein; pfam02441 1048834002186 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1048834002187 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1048834002188 dinuclear metal binding motif [ion binding]; other site 1048834002189 putative sialic acid transporter; Region: 2A0112; TIGR00891 1048834002190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834002191 putative substrate translocation pore; other site 1048834002192 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1048834002193 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1048834002194 NAD(P) binding site [chemical binding]; other site 1048834002195 catalytic residues [active] 1048834002196 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1048834002197 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 1048834002198 active site 1048834002199 metal binding site [ion binding]; metal-binding site 1048834002200 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1048834002201 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1048834002202 acyl-activating enzyme (AAE) consensus motif; other site 1048834002203 AMP binding site [chemical binding]; other site 1048834002204 active site 1048834002205 CoA binding site [chemical binding]; other site 1048834002206 Response regulator receiver domain; Region: Response_reg; pfam00072 1048834002207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834002208 active site 1048834002209 phosphorylation site [posttranslational modification] 1048834002210 intermolecular recognition site; other site 1048834002211 dimerization interface [polypeptide binding]; other site 1048834002212 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1048834002213 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048834002214 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048834002215 potential frameshift: common BLAST hit: gi|379721124|ref|YP_005313255.1| PP-loop domain-containing protein 1048834002216 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1048834002217 Ligand Binding Site [chemical binding]; other site 1048834002218 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1048834002219 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1048834002220 AIR carboxylase; Region: AIRC; smart01001 1048834002221 Protein of unknown function DUF111; Region: DUF111; cl03398 1048834002222 Protein of unknown function DUF111; Region: DUF111; cl03398 1048834002223 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1048834002224 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1048834002225 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1048834002226 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 1048834002227 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1048834002228 active site 1048834002229 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cd00758 1048834002230 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1048834002231 MPT binding site; other site 1048834002232 Protein of unknown function DUF111; Region: DUF111; cl03398 1048834002233 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1048834002234 L-lactate permease; Region: Lactate_perm; cl00701 1048834002235 L-lactate permease; Region: Lactate_perm; cl00701 1048834002236 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1048834002237 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1048834002238 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1048834002239 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1048834002240 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1048834002241 active site 1048834002242 catalytic residues [active] 1048834002243 metal binding site [ion binding]; metal-binding site 1048834002244 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1048834002245 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1048834002246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1048834002247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048834002248 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1048834002249 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1048834002250 Phenylacetic acid degradation B; Region: PaaB; pfam06243 1048834002251 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1048834002252 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1048834002253 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1048834002254 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1048834002255 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1048834002256 acyl-activating enzyme (AAE) consensus motif; other site 1048834002257 AMP binding site [chemical binding]; other site 1048834002258 active site 1048834002259 CoA binding site [chemical binding]; other site 1048834002260 conserved hypothetical protein; Region: TIGR02118 1048834002261 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1048834002262 active site 2 [active] 1048834002263 active site 1 [active] 1048834002264 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1048834002265 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1048834002266 tetramerization interface [polypeptide binding]; other site 1048834002267 NAD(P) binding site [chemical binding]; other site 1048834002268 catalytic residues [active] 1048834002269 enoyl-CoA hydratase; Provisional; Region: PRK08140 1048834002270 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1048834002271 substrate binding site [chemical binding]; other site 1048834002272 oxyanion hole (OAH) forming residues; other site 1048834002273 trimer interface [polypeptide binding]; other site 1048834002274 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1048834002275 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1048834002276 dimer interface [polypeptide binding]; other site 1048834002277 active site 1048834002278 RmuC family; Region: RmuC; pfam02646 1048834002279 YjzC-like protein; Region: YjzC; pfam14168 1048834002280 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1048834002281 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1048834002282 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1048834002283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048834002284 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1048834002285 dimerization interface [polypeptide binding]; other site 1048834002286 substrate binding pocket [chemical binding]; other site 1048834002287 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1048834002288 CoenzymeA binding site [chemical binding]; other site 1048834002289 subunit interaction site [polypeptide binding]; other site 1048834002290 PHB binding site; other site 1048834002291 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 1048834002292 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1048834002293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048834002294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834002295 homodimer interface [polypeptide binding]; other site 1048834002296 catalytic residue [active] 1048834002297 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1048834002298 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1048834002299 TPP-binding site [chemical binding]; other site 1048834002300 tetramer interface [polypeptide binding]; other site 1048834002301 heterodimer interface [polypeptide binding]; other site 1048834002302 phosphorylation loop region [posttranslational modification] 1048834002303 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1048834002304 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1048834002305 alpha subunit interface [polypeptide binding]; other site 1048834002306 TPP binding site [chemical binding]; other site 1048834002307 heterodimer interface [polypeptide binding]; other site 1048834002308 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1048834002309 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1048834002310 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1048834002311 E3 interaction surface; other site 1048834002312 lipoyl attachment site [posttranslational modification]; other site 1048834002313 e3 binding domain; Region: E3_binding; pfam02817 1048834002314 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1048834002315 enoyl-CoA hydratase; Provisional; Region: PRK06688 1048834002316 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1048834002317 substrate binding site [chemical binding]; other site 1048834002318 oxyanion hole (OAH) forming residues; other site 1048834002319 trimer interface [polypeptide binding]; other site 1048834002320 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1048834002321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834002322 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1048834002323 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1048834002324 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1048834002325 catalytic Zn binding site [ion binding]; other site 1048834002326 NAD(P) binding site [chemical binding]; other site 1048834002327 structural Zn binding site [ion binding]; other site 1048834002328 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1048834002329 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048834002330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834002331 Walker A/P-loop; other site 1048834002332 ATP binding site [chemical binding]; other site 1048834002333 Q-loop/lid; other site 1048834002334 ABC transporter signature motif; other site 1048834002335 Walker B; other site 1048834002336 D-loop; other site 1048834002337 H-loop/switch region; other site 1048834002338 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048834002339 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1048834002340 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048834002341 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1048834002342 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1048834002343 Walker A/P-loop; other site 1048834002344 ATP binding site [chemical binding]; other site 1048834002345 Q-loop/lid; other site 1048834002346 ABC transporter signature motif; other site 1048834002347 Walker B; other site 1048834002348 D-loop; other site 1048834002349 H-loop/switch region; other site 1048834002350 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1048834002351 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1048834002352 NAD(P) binding site [chemical binding]; other site 1048834002353 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1048834002354 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1048834002355 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1048834002356 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048834002357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834002358 Walker A/P-loop; other site 1048834002359 ATP binding site [chemical binding]; other site 1048834002360 Q-loop/lid; other site 1048834002361 ABC transporter signature motif; other site 1048834002362 Walker B; other site 1048834002363 D-loop; other site 1048834002364 H-loop/switch region; other site 1048834002365 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1048834002366 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048834002367 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1048834002368 Walker A/P-loop; other site 1048834002369 ATP binding site [chemical binding]; other site 1048834002370 Q-loop/lid; other site 1048834002371 ABC transporter signature motif; other site 1048834002372 Walker B; other site 1048834002373 D-loop; other site 1048834002374 H-loop/switch region; other site 1048834002375 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1048834002376 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1048834002377 active site 1048834002378 metal binding site [ion binding]; metal-binding site 1048834002379 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1048834002380 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1048834002381 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1048834002382 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1048834002383 catalytic loop [active] 1048834002384 iron binding site [ion binding]; other site 1048834002385 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1048834002386 4Fe-4S binding domain; Region: Fer4; pfam00037 1048834002387 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1048834002388 [4Fe-4S] binding site [ion binding]; other site 1048834002389 molybdopterin cofactor binding site; other site 1048834002390 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1048834002391 molybdopterin cofactor binding site; other site 1048834002392 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1048834002393 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 1048834002394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048834002395 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1048834002396 active site residue [active] 1048834002397 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048834002398 active site 1048834002399 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048834002400 catalytic tetrad [active] 1048834002401 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1048834002402 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1048834002403 catalytic residues [active] 1048834002404 catalytic nucleophile [active] 1048834002405 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1048834002406 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1048834002407 Probable transposase; Region: OrfB_IS605; pfam01385 1048834002408 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1048834002409 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1048834002410 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1048834002411 active site 1048834002412 catalytic residues [active] 1048834002413 metal binding site [ion binding]; metal-binding site 1048834002414 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1048834002415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834002416 drug efflux system protein MdtG; Provisional; Region: PRK09874 1048834002417 putative substrate translocation pore; other site 1048834002418 potential frameshift: common BLAST hit: gi|150016796|ref|YP_001309050.1| aspartate aminotransferase 1048834002419 aspartate aminotransferase; Provisional; Region: PRK09275 1048834002420 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048834002421 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1048834002422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834002423 homodimer interface [polypeptide binding]; other site 1048834002424 catalytic residue [active] 1048834002425 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1048834002426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1048834002427 Probable transposase; Region: OrfB_IS605; pfam01385 1048834002428 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1048834002429 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1048834002430 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1048834002431 catalytic residues [active] 1048834002432 catalytic nucleophile [active] 1048834002433 Iron permease FTR1 family; Region: FTR1; cl00475 1048834002434 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1048834002435 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048834002436 active site 1048834002437 motif I; other site 1048834002438 motif II; other site 1048834002439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048834002440 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1048834002441 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1048834002442 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1048834002443 active site 1048834002444 Zn binding site [ion binding]; other site 1048834002445 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1048834002446 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1048834002447 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1048834002448 catalytic residues [active] 1048834002449 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1048834002450 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1048834002451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834002452 Walker A/P-loop; other site 1048834002453 ATP binding site [chemical binding]; other site 1048834002454 Q-loop/lid; other site 1048834002455 ABC transporter signature motif; other site 1048834002456 Walker B; other site 1048834002457 D-loop; other site 1048834002458 H-loop/switch region; other site 1048834002459 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1048834002460 Predicted transcriptional regulators [Transcription]; Region: COG1733 1048834002461 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1048834002462 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1048834002463 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1048834002464 active site 1048834002465 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1048834002466 ATP-sulfurylase; Region: ATPS; cd00517 1048834002467 active site 1048834002468 HXXH motif; other site 1048834002469 flexible loop; other site 1048834002470 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 1048834002471 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1048834002472 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1048834002473 active site 1048834002474 HIGH motif; other site 1048834002475 nucleotide binding site [chemical binding]; other site 1048834002476 active site 1048834002477 KMSKS motif; other site 1048834002478 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1048834002479 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 1048834002480 NAD(P) binding site [chemical binding]; other site 1048834002481 catalytic residues [active] 1048834002482 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048834002483 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048834002484 active site 1048834002485 catalytic tetrad [active] 1048834002486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834002487 S-adenosylmethionine binding site [chemical binding]; other site 1048834002488 Isochorismatase family; Region: Isochorismatase; pfam00857 1048834002489 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1048834002490 catalytic triad [active] 1048834002491 conserved cis-peptide bond; other site 1048834002492 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1048834002493 active site 1048834002494 catalytic triad [active] 1048834002495 oxyanion hole [active] 1048834002496 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1048834002497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834002498 putative substrate translocation pore; other site 1048834002499 Part of AAA domain; Region: AAA_19; pfam13245 1048834002500 Family description; Region: UvrD_C_2; pfam13538 1048834002501 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1048834002502 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048834002503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048834002504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834002505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048834002506 putative substrate translocation pore; other site 1048834002507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834002508 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1048834002509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048834002510 Coenzyme A binding pocket [chemical binding]; other site 1048834002511 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1048834002512 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1048834002513 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1048834002514 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1048834002515 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1048834002516 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1048834002517 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1048834002518 catalytic residues [active] 1048834002519 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1048834002520 CoA binding domain; Region: CoA_binding_2; pfam13380 1048834002521 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1048834002522 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1048834002523 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1048834002524 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1048834002525 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048834002526 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1048834002527 active site 1048834002528 phosphorylation site [posttranslational modification] 1048834002529 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1048834002530 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1048834002531 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1048834002532 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1048834002533 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1048834002534 putative substrate binding site [chemical binding]; other site 1048834002535 putative ATP binding site [chemical binding]; other site 1048834002536 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1048834002537 active site 1048834002538 P-loop; other site 1048834002539 phosphorylation site [posttranslational modification] 1048834002540 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1048834002541 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1048834002542 amidase; Provisional; Region: PRK06828 1048834002543 Amidase; Region: Amidase; cl11426 1048834002544 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1048834002545 EamA-like transporter family; Region: EamA; pfam00892 1048834002546 EamA-like transporter family; Region: EamA; pfam00892 1048834002547 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1048834002548 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1048834002549 structural tetrad; other site 1048834002550 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1048834002551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1048834002552 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1048834002553 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1048834002554 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1048834002555 dimerization interface [polypeptide binding]; other site 1048834002556 putative DNA binding site [nucleotide binding]; other site 1048834002557 putative Zn2+ binding site [ion binding]; other site 1048834002558 SWIM zinc finger; Region: SWIM; pfam04434 1048834002559 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1048834002560 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1048834002561 homodimer interface [polypeptide binding]; other site 1048834002562 substrate-cofactor binding pocket; other site 1048834002563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834002564 catalytic residue [active] 1048834002565 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1048834002566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834002567 S-adenosylmethionine binding site [chemical binding]; other site 1048834002568 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1048834002569 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1048834002570 TPP-binding site [chemical binding]; other site 1048834002571 tetramer interface [polypeptide binding]; other site 1048834002572 heterodimer interface [polypeptide binding]; other site 1048834002573 phosphorylation loop region [posttranslational modification] 1048834002574 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1048834002575 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1048834002576 alpha subunit interface [polypeptide binding]; other site 1048834002577 TPP binding site [chemical binding]; other site 1048834002578 heterodimer interface [polypeptide binding]; other site 1048834002579 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1048834002580 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 1048834002581 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1048834002582 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 1048834002583 acyl-activating enzyme (AAE) consensus motif; other site 1048834002584 putative AMP binding site [chemical binding]; other site 1048834002585 putative active site [active] 1048834002586 putative CoA binding site [chemical binding]; other site 1048834002587 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1048834002588 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1048834002589 phosphate binding site [ion binding]; other site 1048834002590 Maf-like protein; Region: Maf; pfam02545 1048834002591 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1048834002592 active site 1048834002593 dimer interface [polypeptide binding]; other site 1048834002594 HI0933-like protein; Region: HI0933_like; pfam03486 1048834002595 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1048834002596 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1048834002597 dimer interface [polypeptide binding]; other site 1048834002598 active site 1048834002599 metal binding site [ion binding]; metal-binding site 1048834002600 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1048834002601 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048834002602 DNA binding site [nucleotide binding] 1048834002603 domain linker motif; other site 1048834002604 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1048834002605 dimerization interface [polypeptide binding]; other site 1048834002606 ligand binding site [chemical binding]; other site 1048834002607 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1048834002608 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1048834002609 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1048834002610 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1048834002611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834002612 dimer interface [polypeptide binding]; other site 1048834002613 conserved gate region; other site 1048834002614 putative PBP binding loops; other site 1048834002615 ABC-ATPase subunit interface; other site 1048834002616 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1048834002617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834002618 dimer interface [polypeptide binding]; other site 1048834002619 conserved gate region; other site 1048834002620 putative PBP binding loops; other site 1048834002621 ABC-ATPase subunit interface; other site 1048834002622 aconitate hydratase; Validated; Region: PRK09277 1048834002623 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1048834002624 substrate binding site [chemical binding]; other site 1048834002625 ligand binding site [chemical binding]; other site 1048834002626 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1048834002627 substrate binding site [chemical binding]; other site 1048834002628 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1048834002629 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1048834002630 Mg++ binding site [ion binding]; other site 1048834002631 putative catalytic motif [active] 1048834002632 substrate binding site [chemical binding]; other site 1048834002633 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1048834002634 UbiA prenyltransferase family; Region: UbiA; pfam01040 1048834002635 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1048834002636 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 1048834002637 putative NAD(P) binding site [chemical binding]; other site 1048834002638 catalytic Zn binding site [ion binding]; other site 1048834002639 structural Zn binding site [ion binding]; other site 1048834002640 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1048834002641 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1048834002642 NAD(P) binding site [chemical binding]; other site 1048834002643 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1048834002644 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1048834002645 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1048834002646 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048834002647 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 1048834002648 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1048834002649 motif 1; other site 1048834002650 dimer interface [polypeptide binding]; other site 1048834002651 active site 1048834002652 motif 2; other site 1048834002653 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1048834002654 active site 1048834002655 motif 3; other site 1048834002656 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1048834002657 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1048834002658 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1048834002659 histidinol dehydrogenase; Region: hisD; TIGR00069 1048834002660 NAD binding site [chemical binding]; other site 1048834002661 dimerization interface [polypeptide binding]; other site 1048834002662 product binding site; other site 1048834002663 substrate binding site [chemical binding]; other site 1048834002664 zinc binding site [ion binding]; other site 1048834002665 catalytic residues [active] 1048834002666 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1048834002667 putative active site pocket [active] 1048834002668 4-fold oligomerization interface [polypeptide binding]; other site 1048834002669 metal binding residues [ion binding]; metal-binding site 1048834002670 3-fold/trimer interface [polypeptide binding]; other site 1048834002671 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1048834002672 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1048834002673 putative active site [active] 1048834002674 oxyanion strand; other site 1048834002675 catalytic triad [active] 1048834002676 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1048834002677 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1048834002678 catalytic residues [active] 1048834002679 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1048834002680 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1048834002681 substrate binding site [chemical binding]; other site 1048834002682 glutamase interaction surface [polypeptide binding]; other site 1048834002683 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1048834002684 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1048834002685 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1048834002686 metal binding site [ion binding]; metal-binding site 1048834002687 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1048834002688 EamA-like transporter family; Region: EamA; pfam00892 1048834002689 EamA-like transporter family; Region: EamA; pfam00892 1048834002690 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1048834002691 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1048834002692 putative NAD(P) binding site [chemical binding]; other site 1048834002693 dimer interface [polypeptide binding]; other site 1048834002694 amino acid transporter; Region: 2A0306; TIGR00909 1048834002695 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1048834002696 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1048834002697 catalytic motif [active] 1048834002698 Zn binding site [ion binding]; other site 1048834002699 RibD C-terminal domain; Region: RibD_C; cl17279 1048834002700 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1048834002701 Lumazine binding domain; Region: Lum_binding; pfam00677 1048834002702 Lumazine binding domain; Region: Lum_binding; pfam00677 1048834002703 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1048834002704 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1048834002705 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1048834002706 dimerization interface [polypeptide binding]; other site 1048834002707 active site 1048834002708 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1048834002709 homopentamer interface [polypeptide binding]; other site 1048834002710 active site 1048834002711 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1048834002712 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1048834002713 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1048834002714 Walker A/P-loop; other site 1048834002715 ATP binding site [chemical binding]; other site 1048834002716 Q-loop/lid; other site 1048834002717 ABC transporter signature motif; other site 1048834002718 Walker B; other site 1048834002719 D-loop; other site 1048834002720 H-loop/switch region; other site 1048834002721 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1048834002722 Walker A/P-loop; other site 1048834002723 ATP binding site [chemical binding]; other site 1048834002724 Q-loop/lid; other site 1048834002725 ABC transporter signature motif; other site 1048834002726 Walker B; other site 1048834002727 D-loop; other site 1048834002728 H-loop/switch region; other site 1048834002729 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1048834002730 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1048834002731 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1048834002732 TPP-binding site [chemical binding]; other site 1048834002733 dimer interface [polypeptide binding]; other site 1048834002734 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1048834002735 PYR/PP interface [polypeptide binding]; other site 1048834002736 dimer interface [polypeptide binding]; other site 1048834002737 TPP binding site [chemical binding]; other site 1048834002738 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1048834002739 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1048834002740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048834002741 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1048834002742 dimerization interface [polypeptide binding]; other site 1048834002743 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1048834002744 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1048834002745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048834002746 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1048834002747 NAD(P) binding site [chemical binding]; other site 1048834002748 active site 1048834002749 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1048834002750 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1048834002751 active site residue [active] 1048834002752 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1048834002753 active site residue [active] 1048834002754 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1048834002755 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1048834002756 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1048834002757 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1048834002758 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1048834002759 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1048834002760 active site 1048834002761 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1048834002762 conserved cys residue [active] 1048834002763 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1048834002764 Part of AAA domain; Region: AAA_19; pfam13245 1048834002765 Family description; Region: UvrD_C_2; pfam13538 1048834002766 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1048834002767 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1048834002768 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048834002769 Coenzyme A binding pocket [chemical binding]; other site 1048834002770 NifU-like domain; Region: NifU; cl00484 1048834002771 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1048834002772 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1048834002773 active site 1048834002774 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1048834002775 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1048834002776 homooctamer interface [polypeptide binding]; other site 1048834002777 active site 1048834002778 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1048834002779 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1048834002780 G1 box; other site 1048834002781 GTP/Mg2+ binding site [chemical binding]; other site 1048834002782 G2 box; other site 1048834002783 Switch I region; other site 1048834002784 G3 box; other site 1048834002785 Switch II region; other site 1048834002786 G4 box; other site 1048834002787 G5 box; other site 1048834002788 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1048834002789 Dynamin family; Region: Dynamin_N; pfam00350 1048834002790 G1 box; other site 1048834002791 GTP/Mg2+ binding site [chemical binding]; other site 1048834002792 G2 box; other site 1048834002793 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1048834002794 G3 box; other site 1048834002795 Switch II region; other site 1048834002796 G4 box; other site 1048834002797 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1048834002798 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1048834002799 protein binding site [polypeptide binding]; other site 1048834002800 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048834002801 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048834002802 DNA binding residues [nucleotide binding] 1048834002803 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1048834002804 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1048834002805 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1048834002806 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1048834002807 catalytic residues [active] 1048834002808 catalytic nucleophile [active] 1048834002809 Recombinase; Region: Recombinase; pfam07508 1048834002810 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1048834002811 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1048834002812 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1048834002813 active site 1048834002814 catalytic triad [active] 1048834002815 oxyanion hole [active] 1048834002816 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1048834002817 homodecamer interface [polypeptide binding]; other site 1048834002818 GTP cyclohydrolase I; Provisional; Region: PLN03044 1048834002819 active site 1048834002820 putative catalytic site residues [active] 1048834002821 zinc binding site [ion binding]; other site 1048834002822 GTP-CH-I/GFRP interaction surface; other site 1048834002823 isoaspartyl dipeptidase; Provisional; Region: PRK10657 1048834002824 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1048834002825 active site 1048834002826 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1048834002827 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1048834002828 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1048834002829 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1048834002830 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1048834002831 NAD binding site [chemical binding]; other site 1048834002832 homotetramer interface [polypeptide binding]; other site 1048834002833 homodimer interface [polypeptide binding]; other site 1048834002834 substrate binding site [chemical binding]; other site 1048834002835 active site 1048834002836 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1048834002837 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1048834002838 quinone interaction residues [chemical binding]; other site 1048834002839 active site 1048834002840 catalytic residues [active] 1048834002841 FMN binding site [chemical binding]; other site 1048834002842 substrate binding site [chemical binding]; other site 1048834002843 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 1048834002844 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048834002845 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048834002846 DNA binding residues [nucleotide binding] 1048834002847 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1048834002848 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1048834002849 hexamer interface [polypeptide binding]; other site 1048834002850 ligand binding site [chemical binding]; other site 1048834002851 putative active site [active] 1048834002852 NAD(P) binding site [chemical binding]; other site 1048834002853 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1048834002854 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1048834002855 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1048834002856 Walker A/P-loop; other site 1048834002857 ATP binding site [chemical binding]; other site 1048834002858 Q-loop/lid; other site 1048834002859 ABC transporter signature motif; other site 1048834002860 Walker B; other site 1048834002861 D-loop; other site 1048834002862 H-loop/switch region; other site 1048834002863 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1048834002864 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1048834002865 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1048834002866 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1048834002867 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1048834002868 catalytic residue [active] 1048834002869 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1048834002870 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1048834002871 trimerization site [polypeptide binding]; other site 1048834002872 active site 1048834002873 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1048834002874 FeS assembly protein SufB; Region: sufB; TIGR01980 1048834002875 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1048834002876 [2Fe-2S] cluster binding site [ion binding]; other site 1048834002877 Predicted transcriptional regulator [Transcription]; Region: COG1959 1048834002878 Transcriptional regulator; Region: Rrf2; pfam02082 1048834002879 Transcriptional regulator; Region: Rrf2; cl17282 1048834002880 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1048834002881 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1048834002882 active site 1048834002883 dimerization interface [polypeptide binding]; other site 1048834002884 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1048834002885 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1048834002886 active site 1048834002887 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1048834002888 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1048834002889 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1048834002890 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 1048834002891 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1048834002892 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1048834002893 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1048834002894 active site 1048834002895 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1048834002896 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1048834002897 SNF2 Helicase protein; Region: DUF3670; pfam12419 1048834002898 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1048834002899 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048834002900 ATP binding site [chemical binding]; other site 1048834002901 putative Mg++ binding site [ion binding]; other site 1048834002902 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048834002903 nucleotide binding region [chemical binding]; other site 1048834002904 ATP-binding site [chemical binding]; other site 1048834002905 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1048834002906 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1048834002907 Y-family of DNA polymerases; Region: PolY; cl12025 1048834002908 active site 1048834002909 DNA binding site [nucleotide binding] 1048834002910 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1048834002911 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1048834002912 active site 1048834002913 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1048834002914 generic binding surface II; other site 1048834002915 generic binding surface I; other site 1048834002916 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1048834002917 putative active site [active] 1048834002918 catalytic site [active] 1048834002919 PLD-like domain; Region: PLDc_2; pfam13091 1048834002920 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1048834002921 putative active site [active] 1048834002922 catalytic site [active] 1048834002923 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1048834002924 active site 1048834002925 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1048834002926 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1048834002927 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1048834002928 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1048834002929 nucleotide binding site/active site [active] 1048834002930 HIT family signature motif; other site 1048834002931 catalytic residue [active] 1048834002932 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1048834002933 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1048834002934 homodimer interface [polypeptide binding]; other site 1048834002935 substrate-cofactor binding pocket; other site 1048834002936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834002937 catalytic residue [active] 1048834002938 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 1048834002939 homodimer interface [polypeptide binding]; other site 1048834002940 metal binding site [ion binding]; metal-binding site 1048834002941 endonuclease IV; Provisional; Region: PRK01060 1048834002942 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1048834002943 AP (apurinic/apyrimidinic) site pocket; other site 1048834002944 DNA interaction; other site 1048834002945 Metal-binding active site; metal-binding site 1048834002946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834002947 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048834002948 putative substrate translocation pore; other site 1048834002949 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1048834002950 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1048834002951 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1048834002952 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1048834002953 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1048834002954 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1048834002955 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1048834002956 threonine synthase; Reviewed; Region: PRK06721 1048834002957 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1048834002958 homodimer interface [polypeptide binding]; other site 1048834002959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834002960 catalytic residue [active] 1048834002961 homoserine kinase; Provisional; Region: PRK01212 1048834002962 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1048834002963 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1048834002964 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1048834002965 CoenzymeA binding site [chemical binding]; other site 1048834002966 subunit interaction site [polypeptide binding]; other site 1048834002967 PHB binding site; other site 1048834002968 putative transposase OrfB; Reviewed; Region: PHA02517 1048834002969 HTH-like domain; Region: HTH_21; pfam13276 1048834002970 Integrase core domain; Region: rve; pfam00665 1048834002971 Integrase core domain; Region: rve_3; pfam13683 1048834002972 Transposase; Region: HTH_Tnp_1; cl17663 1048834002973 HTH-like domain; Region: HTH_21; pfam13276 1048834002974 Integrase core domain; Region: rve; pfam00665 1048834002975 Integrase core domain; Region: rve_3; pfam13683 1048834002976 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1048834002977 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1048834002978 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834002979 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1048834002980 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1048834002981 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1048834002982 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834002983 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1048834002984 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1048834002985 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834002986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1048834002987 Integrase core domain; Region: rve; pfam00665 1048834002988 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1048834002989 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1048834002990 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834002991 Walker A motif; other site 1048834002992 ATP binding site [chemical binding]; other site 1048834002993 Walker B motif; other site 1048834002994 Transposase domain (DUF772); Region: DUF772; pfam05598 1048834002995 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834002996 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1048834002997 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1048834002998 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1048834002999 nudix motif; other site 1048834003000 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1048834003001 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1048834003002 catalytic triad [active] 1048834003003 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1048834003004 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1048834003005 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1048834003006 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 1048834003007 ArsC family; Region: ArsC; pfam03960 1048834003008 catalytic residue [active] 1048834003009 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1048834003010 cell division protein FtsW; Region: ftsW; TIGR02614 1048834003011 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1048834003012 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1048834003013 putative active site [active] 1048834003014 putative metal binding site [ion binding]; other site 1048834003015 catalytic site [active] 1048834003016 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1048834003017 transaminase; Reviewed; Region: PRK08068 1048834003018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048834003019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834003020 homodimer interface [polypeptide binding]; other site 1048834003021 catalytic residue [active] 1048834003022 Stage II sporulation protein; Region: SpoIID; pfam08486 1048834003023 YwhD family; Region: YwhD; pfam08741 1048834003024 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1048834003025 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1048834003026 homodimer interface [polypeptide binding]; other site 1048834003027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834003028 catalytic residue [active] 1048834003029 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1048834003030 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1048834003031 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1048834003032 catalytic triad [active] 1048834003033 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1048834003034 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1048834003035 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1048834003036 Zn2+ binding site [ion binding]; other site 1048834003037 Mg2+ binding site [ion binding]; other site 1048834003038 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1048834003039 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1048834003040 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 1048834003041 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1048834003042 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1048834003043 oligomer interface [polypeptide binding]; other site 1048834003044 active site 1048834003045 metal binding site [ion binding]; metal-binding site 1048834003046 Divergent PAP2 family; Region: DUF212; pfam02681 1048834003047 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1048834003048 nudix motif; other site 1048834003049 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1048834003050 3D domain; Region: 3D; cl01439 1048834003051 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1048834003052 NlpC/P60 family; Region: NLPC_P60; cl17555 1048834003053 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1048834003054 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1048834003055 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1048834003056 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1048834003057 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1048834003058 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1048834003059 NAD(P) binding site [chemical binding]; other site 1048834003060 catalytic residues [active] 1048834003061 Small acid-soluble spore protein H family; Region: SspH; pfam08141 1048834003062 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1048834003063 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1048834003064 FMN binding site [chemical binding]; other site 1048834003065 substrate binding site [chemical binding]; other site 1048834003066 putative catalytic residue [active] 1048834003067 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1048834003068 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1048834003069 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1048834003070 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1048834003071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1048834003072 Transposase; Region: HTH_Tnp_1; pfam01527 1048834003073 putative transposase OrfB; Reviewed; Region: PHA02517 1048834003074 HTH-like domain; Region: HTH_21; pfam13276 1048834003075 Integrase core domain; Region: rve; pfam00665 1048834003076 Integrase core domain; Region: rve_3; pfam13683 1048834003077 putative transposase OrfB; Reviewed; Region: PHA02517 1048834003078 HTH-like domain; Region: HTH_21; pfam13276 1048834003079 Integrase core domain; Region: rve; pfam00665 1048834003080 Integrase core domain; Region: rve_3; pfam13683 1048834003081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1048834003082 Transposase; Region: HTH_Tnp_1; pfam01527 1048834003083 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1048834003084 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1048834003085 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1048834003086 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1048834003087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834003088 putative PBP binding loops; other site 1048834003089 dimer interface [polypeptide binding]; other site 1048834003090 ABC-ATPase subunit interface; other site 1048834003091 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1048834003092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834003093 dimer interface [polypeptide binding]; other site 1048834003094 conserved gate region; other site 1048834003095 putative PBP binding loops; other site 1048834003096 ABC-ATPase subunit interface; other site 1048834003097 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1048834003098 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1048834003099 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1048834003100 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1048834003101 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1048834003102 Integrase core domain; Region: rve; pfam00665 1048834003103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834003104 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1048834003105 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1048834003106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834003107 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1048834003108 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1048834003109 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1048834003110 HTH-like domain; Region: HTH_21; pfam13276 1048834003111 Integrase core domain; Region: rve; pfam00665 1048834003112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1048834003113 Transposase; Region: HTH_Tnp_1; pfam01527 1048834003114 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 1048834003115 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1048834003116 active site 1048834003117 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1048834003118 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1048834003119 substrate binding site [chemical binding]; other site 1048834003120 oxyanion hole (OAH) forming residues; other site 1048834003121 trimer interface [polypeptide binding]; other site 1048834003122 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 1048834003123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048834003124 NAD(P) binding site [chemical binding]; other site 1048834003125 active site 1048834003126 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1048834003127 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1048834003128 acyl-activating enzyme (AAE) consensus motif; other site 1048834003129 active site 1048834003130 AMP binding site [chemical binding]; other site 1048834003131 CoA binding site [chemical binding]; other site 1048834003132 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1048834003133 CoA binding site [chemical binding]; other site 1048834003134 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1048834003135 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1048834003136 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048834003137 DNA binding site [nucleotide binding] 1048834003138 domain linker motif; other site 1048834003139 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1048834003140 ligand binding site [chemical binding]; other site 1048834003141 dimerization interface [polypeptide binding]; other site 1048834003142 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1048834003143 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1048834003144 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1048834003145 glutamine binding [chemical binding]; other site 1048834003146 catalytic triad [active] 1048834003147 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1048834003148 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1048834003149 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1048834003150 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1048834003151 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1048834003152 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1048834003153 nucleotide binding site [chemical binding]; other site 1048834003154 N-acetyl-L-glutamate binding site [chemical binding]; other site 1048834003155 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1048834003156 acetylornithine aminotransferase; Provisional; Region: PRK02627 1048834003157 inhibitor-cofactor binding pocket; inhibition site 1048834003158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834003159 catalytic residue [active] 1048834003160 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1048834003161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048834003162 Coenzyme A binding pocket [chemical binding]; other site 1048834003163 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1048834003164 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1048834003165 active site 1048834003166 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1048834003167 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1048834003168 active site 1048834003169 FMN binding site [chemical binding]; other site 1048834003170 substrate binding site [chemical binding]; other site 1048834003171 3Fe-4S cluster binding site [ion binding]; other site 1048834003172 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 1048834003173 domain_subunit interface; other site 1048834003174 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1048834003175 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1048834003176 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1048834003177 argininosuccinate synthase; Provisional; Region: PRK13820 1048834003178 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1048834003179 ANP binding site [chemical binding]; other site 1048834003180 Substrate Binding Site II [chemical binding]; other site 1048834003181 Substrate Binding Site I [chemical binding]; other site 1048834003182 argininosuccinate lyase; Provisional; Region: PRK00855 1048834003183 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1048834003184 active sites [active] 1048834003185 tetramer interface [polypeptide binding]; other site 1048834003186 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1048834003187 aspartate kinase; Reviewed; Region: PRK06635 1048834003188 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1048834003189 putative nucleotide binding site [chemical binding]; other site 1048834003190 putative catalytic residues [active] 1048834003191 putative Mg ion binding site [ion binding]; other site 1048834003192 putative aspartate binding site [chemical binding]; other site 1048834003193 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1048834003194 putative allosteric regulatory site; other site 1048834003195 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1048834003196 putative allosteric regulatory residue; other site 1048834003197 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1048834003198 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1048834003199 ligand binding site [chemical binding]; other site 1048834003200 NAD binding site [chemical binding]; other site 1048834003201 dimerization interface [polypeptide binding]; other site 1048834003202 catalytic site [active] 1048834003203 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1048834003204 putative L-serine binding site [chemical binding]; other site 1048834003205 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1048834003206 homodimer interface [polypeptide binding]; other site 1048834003207 substrate-cofactor binding pocket; other site 1048834003208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834003209 catalytic residue [active] 1048834003210 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1048834003211 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048834003212 motif II; other site 1048834003213 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1048834003214 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834003215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048834003216 ATP binding site [chemical binding]; other site 1048834003217 putative Mg++ binding site [ion binding]; other site 1048834003218 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1048834003219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048834003220 nucleotide binding region [chemical binding]; other site 1048834003221 ATP-binding site [chemical binding]; other site 1048834003222 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1048834003223 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 1048834003224 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1048834003225 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 1048834003226 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 1048834003227 transposase/IS protein; Provisional; Region: PRK09183 1048834003228 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834003229 Walker A motif; other site 1048834003230 ATP binding site [chemical binding]; other site 1048834003231 Walker B motif; other site 1048834003232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1048834003233 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1048834003234 Integrase core domain; Region: rve; pfam00665 1048834003235 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834003236 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1048834003237 Transposase domain (DUF772); Region: DUF772; pfam05598 1048834003238 Predicted transcriptional regulators [Transcription]; Region: COG1725 1048834003239 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048834003240 DNA-binding site [nucleotide binding]; DNA binding site 1048834003241 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1048834003242 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1048834003243 Walker A/P-loop; other site 1048834003244 ATP binding site [chemical binding]; other site 1048834003245 Q-loop/lid; other site 1048834003246 ABC transporter signature motif; other site 1048834003247 Walker B; other site 1048834003248 D-loop; other site 1048834003249 H-loop/switch region; other site 1048834003250 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1048834003251 active site residue [active] 1048834003252 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1048834003253 catalytic residues [active] 1048834003254 Domain of unknown function DUF302; Region: DUF302; cl01364 1048834003255 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 1048834003256 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 1048834003257 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1048834003258 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1048834003259 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1048834003260 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1048834003261 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1048834003262 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048834003263 DNA-binding site [nucleotide binding]; DNA binding site 1048834003264 FCD domain; Region: FCD; pfam07729 1048834003265 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 1048834003266 acetyl-CoA synthetase; Provisional; Region: PRK00174 1048834003267 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1048834003268 active site 1048834003269 CoA binding site [chemical binding]; other site 1048834003270 acyl-activating enzyme (AAE) consensus motif; other site 1048834003271 AMP binding site [chemical binding]; other site 1048834003272 acetate binding site [chemical binding]; other site 1048834003273 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 1048834003274 Protein of unknown function (DUF964); Region: DUF964; pfam06133 1048834003275 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1048834003276 Clp protease; Region: CLP_protease; pfam00574 1048834003277 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1048834003278 oligomer interface [polypeptide binding]; other site 1048834003279 active site residues [active] 1048834003280 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1048834003281 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1048834003282 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1048834003283 catalytic residue [active] 1048834003284 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1048834003285 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1048834003286 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1048834003287 Ligand Binding Site [chemical binding]; other site 1048834003288 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1048834003289 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1048834003290 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1048834003291 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1048834003292 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1048834003293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048834003294 NAD(P) binding site [chemical binding]; other site 1048834003295 active site 1048834003296 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1048834003297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1048834003298 cell division protein MraZ; Reviewed; Region: PRK00326 1048834003299 MraZ protein; Region: MraZ; pfam02381 1048834003300 MraZ protein; Region: MraZ; pfam02381 1048834003301 MraW methylase family; Region: Methyltransf_5; cl17771 1048834003302 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1048834003303 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1048834003304 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1048834003305 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1048834003306 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1048834003307 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1048834003308 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1048834003309 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1048834003310 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1048834003311 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1048834003312 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1048834003313 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1048834003314 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1048834003315 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1048834003316 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1048834003317 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1048834003318 Mg++ binding site [ion binding]; other site 1048834003319 putative catalytic motif [active] 1048834003320 putative substrate binding site [chemical binding]; other site 1048834003321 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1048834003322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048834003323 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1048834003324 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1048834003325 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1048834003326 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1048834003327 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1048834003328 active site 1048834003329 homodimer interface [polypeptide binding]; other site 1048834003330 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1048834003331 FAD binding domain; Region: FAD_binding_4; pfam01565 1048834003332 SLIDE; Region: SLIDE; pfam09111 1048834003333 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1048834003334 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1048834003335 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1048834003336 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1048834003337 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1048834003338 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1048834003339 catalytic residues [active] 1048834003340 catalytic nucleophile [active] 1048834003341 Presynaptic Site I dimer interface [polypeptide binding]; other site 1048834003342 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1048834003343 Synaptic Flat tetramer interface [polypeptide binding]; other site 1048834003344 Synaptic Site I dimer interface [polypeptide binding]; other site 1048834003345 DNA binding site [nucleotide binding] 1048834003346 Recombinase; Region: Recombinase; pfam07508 1048834003347 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1048834003348 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1048834003349 active site 1048834003350 hinge; other site 1048834003351 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1048834003352 Cell division protein FtsQ; Region: FtsQ; pfam03799 1048834003353 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1048834003354 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1048834003355 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1048834003356 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1048834003357 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1048834003358 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1048834003359 nucleotide binding site [chemical binding]; other site 1048834003360 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1048834003361 Cell division protein FtsA; Region: FtsA; pfam14450 1048834003362 cell division protein FtsZ; Validated; Region: PRK09330 1048834003363 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1048834003364 nucleotide binding site [chemical binding]; other site 1048834003365 SulA interaction site; other site 1048834003366 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1048834003367 MULE transposase domain; Region: MULE; pfam10551 1048834003368 HTH-like domain; Region: HTH_21; pfam13276 1048834003369 Integrase core domain; Region: rve; pfam00665 1048834003370 Integrase core domain; Region: rve_2; pfam13333 1048834003371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1048834003372 Transposase; Region: HTH_Tnp_1; pfam01527 1048834003373 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1048834003374 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1048834003375 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1048834003376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048834003377 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048834003378 DNA binding residues [nucleotide binding] 1048834003379 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1048834003380 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048834003381 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1048834003382 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048834003383 DNA binding residues [nucleotide binding] 1048834003384 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1048834003385 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1048834003386 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1048834003387 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1048834003388 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1048834003389 catalytic residue [active] 1048834003390 YGGT family; Region: YGGT; cl00508 1048834003391 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1048834003392 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1048834003393 DivIVA protein; Region: DivIVA; pfam05103 1048834003394 DivIVA domain; Region: DivI1A_domain; TIGR03544 1048834003395 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1048834003396 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 1048834003397 lipoprotein signal peptidase; Provisional; Region: PRK14787 1048834003398 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 1048834003399 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1048834003400 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1048834003401 active site 1048834003402 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1048834003403 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048834003404 active site 1048834003405 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1048834003406 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1048834003407 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1048834003408 dihydroorotase; Validated; Region: pyrC; PRK09357 1048834003409 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1048834003410 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1048834003411 active site 1048834003412 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1048834003413 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1048834003414 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1048834003415 catalytic site [active] 1048834003416 subunit interface [polypeptide binding]; other site 1048834003417 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1048834003418 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1048834003419 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1048834003420 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1048834003421 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1048834003422 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1048834003423 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1048834003424 IMP binding site; other site 1048834003425 dimer interface [polypeptide binding]; other site 1048834003426 interdomain contacts; other site 1048834003427 partial ornithine binding site; other site 1048834003428 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1048834003429 active site 1048834003430 dimer interface [polypeptide binding]; other site 1048834003431 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048834003432 active site 1048834003433 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1048834003434 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1048834003435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834003436 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048834003437 putative substrate translocation pore; other site 1048834003438 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1048834003439 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1048834003440 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1048834003441 NAD(P) binding site [chemical binding]; other site 1048834003442 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1048834003443 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1048834003444 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1048834003445 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1048834003446 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1048834003447 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1048834003448 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1048834003449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048834003450 motif II; other site 1048834003451 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1048834003452 hypothetical protein; Provisional; Region: PRK11820 1048834003453 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1048834003454 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1048834003455 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1048834003456 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1048834003457 Flavoprotein; Region: Flavoprotein; pfam02441 1048834003458 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1048834003459 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1048834003460 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048834003461 ATP binding site [chemical binding]; other site 1048834003462 putative Mg++ binding site [ion binding]; other site 1048834003463 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1048834003464 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048834003465 nucleotide binding region [chemical binding]; other site 1048834003466 ATP-binding site [chemical binding]; other site 1048834003467 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1048834003468 active site 1048834003469 catalytic residues [active] 1048834003470 metal binding site [ion binding]; metal-binding site 1048834003471 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1048834003472 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1048834003473 putative active site [active] 1048834003474 substrate binding site [chemical binding]; other site 1048834003475 putative cosubstrate binding site; other site 1048834003476 catalytic site [active] 1048834003477 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1048834003478 substrate binding site [chemical binding]; other site 1048834003479 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1048834003480 NusB family; Region: NusB; pfam01029 1048834003481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834003482 S-adenosylmethionine binding site [chemical binding]; other site 1048834003483 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1048834003484 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048834003485 FeS/SAM binding site; other site 1048834003486 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1048834003487 active site 1048834003488 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1048834003489 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1048834003490 active site 1048834003491 ATP binding site [chemical binding]; other site 1048834003492 substrate binding site [chemical binding]; other site 1048834003493 activation loop (A-loop); other site 1048834003494 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1048834003495 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1048834003496 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1048834003497 GTPase RsgA; Reviewed; Region: PRK00098 1048834003498 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1048834003499 RNA binding site [nucleotide binding]; other site 1048834003500 homodimer interface [polypeptide binding]; other site 1048834003501 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1048834003502 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1048834003503 GTP/Mg2+ binding site [chemical binding]; other site 1048834003504 G4 box; other site 1048834003505 G5 box; other site 1048834003506 G1 box; other site 1048834003507 Switch I region; other site 1048834003508 G2 box; other site 1048834003509 G3 box; other site 1048834003510 Switch II region; other site 1048834003511 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1048834003512 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1048834003513 Y-family of DNA polymerases; Region: PolY; cl12025 1048834003514 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1048834003515 generic binding surface I; other site 1048834003516 generic binding surface II; other site 1048834003517 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048834003518 ATP binding site [chemical binding]; other site 1048834003519 putative Mg++ binding site [ion binding]; other site 1048834003520 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048834003521 nucleotide binding region [chemical binding]; other site 1048834003522 ATP-binding site [chemical binding]; other site 1048834003523 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1048834003524 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1048834003525 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 1048834003526 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1048834003527 NAD binding site [chemical binding]; other site 1048834003528 substrate binding site [chemical binding]; other site 1048834003529 active site 1048834003530 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1048834003531 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1048834003532 Amidase; Region: Amidase; pfam01425 1048834003533 indole-3-acetamide amidohydrolase; Region: PLN02722 1048834003534 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1048834003535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834003536 S-adenosylmethionine binding site [chemical binding]; other site 1048834003537 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1048834003538 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1048834003539 active site 1048834003540 (T/H)XGH motif; other site 1048834003541 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1048834003542 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1048834003543 active site 1048834003544 nucleophile elbow; other site 1048834003545 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1048834003546 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1048834003547 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1048834003548 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1048834003549 active site 2 [active] 1048834003550 putative phosphate acyltransferase; Provisional; Region: PRK05331 1048834003551 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1048834003552 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1048834003553 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1048834003554 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1048834003555 NAD(P) binding site [chemical binding]; other site 1048834003556 homotetramer interface [polypeptide binding]; other site 1048834003557 homodimer interface [polypeptide binding]; other site 1048834003558 active site 1048834003559 acyl carrier protein; Provisional; Region: acpP; PRK00982 1048834003560 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1048834003561 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1048834003562 dimer interface [polypeptide binding]; other site 1048834003563 active site 1048834003564 ribonuclease III; Reviewed; Region: rnc; PRK00102 1048834003565 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1048834003566 dimerization interface [polypeptide binding]; other site 1048834003567 active site 1048834003568 metal binding site [ion binding]; metal-binding site 1048834003569 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1048834003570 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1048834003571 AAA domain; Region: AAA_23; pfam13476 1048834003572 Walker A/P-loop; other site 1048834003573 ATP binding site [chemical binding]; other site 1048834003574 Q-loop/lid; other site 1048834003575 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1048834003576 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1048834003577 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1048834003578 ABC transporter signature motif; other site 1048834003579 Walker B; other site 1048834003580 D-loop; other site 1048834003581 H-loop/switch region; other site 1048834003582 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1048834003583 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1048834003584 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1048834003585 P loop; other site 1048834003586 GTP binding site [chemical binding]; other site 1048834003587 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048834003588 DNA binding residues [nucleotide binding] 1048834003589 signal recognition particle protein; Provisional; Region: PRK10867 1048834003590 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1048834003591 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1048834003592 P loop; other site 1048834003593 GTP binding site [chemical binding]; other site 1048834003594 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1048834003595 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1048834003596 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1048834003597 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1048834003598 G-X-X-G motif; other site 1048834003599 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1048834003600 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1048834003601 RimM N-terminal domain; Region: RimM; pfam01782 1048834003602 PRC-barrel domain; Region: PRC; pfam05239 1048834003603 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1048834003604 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1048834003605 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1048834003606 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1048834003607 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1048834003608 substrate-cofactor binding pocket; other site 1048834003609 homodimer interface [polypeptide binding]; other site 1048834003610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834003611 catalytic residue [active] 1048834003612 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1048834003613 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1048834003614 RNA binding surface [nucleotide binding]; other site 1048834003615 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1048834003616 active site 1048834003617 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1048834003618 active site 1048834003619 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1048834003620 Peptidase family M23; Region: Peptidase_M23; pfam01551 1048834003621 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1048834003622 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1048834003623 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1048834003624 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1048834003625 GTP/Mg2+ binding site [chemical binding]; other site 1048834003626 G4 box; other site 1048834003627 G5 box; other site 1048834003628 G1 box; other site 1048834003629 Switch I region; other site 1048834003630 G2 box; other site 1048834003631 G3 box; other site 1048834003632 Switch II region; other site 1048834003633 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1048834003634 RNA/DNA hybrid binding site [nucleotide binding]; other site 1048834003635 active site 1048834003636 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1048834003637 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1048834003638 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1048834003639 NodB motif; other site 1048834003640 active site 1048834003641 catalytic site [active] 1048834003642 metal binding site [ion binding]; metal-binding site 1048834003643 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1048834003644 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1048834003645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834003646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1048834003647 Walker A motif; other site 1048834003648 ATP binding site [chemical binding]; other site 1048834003649 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1048834003650 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1048834003651 CoA-ligase; Region: Ligase_CoA; pfam00549 1048834003652 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1048834003653 CoA binding domain; Region: CoA_binding; smart00881 1048834003654 CoA-ligase; Region: Ligase_CoA; pfam00549 1048834003655 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1048834003656 DNA protecting protein DprA; Region: dprA; TIGR00732 1048834003657 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1048834003658 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1048834003659 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048834003660 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048834003661 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1048834003662 Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749 1048834003663 DNA topoisomerase I; Validated; Region: PRK05582 1048834003664 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1048834003665 active site 1048834003666 interdomain interaction site; other site 1048834003667 putative metal-binding site [ion binding]; other site 1048834003668 nucleotide binding site [chemical binding]; other site 1048834003669 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1048834003670 domain I; other site 1048834003671 DNA binding groove [nucleotide binding] 1048834003672 phosphate binding site [ion binding]; other site 1048834003673 domain II; other site 1048834003674 domain III; other site 1048834003675 nucleotide binding site [chemical binding]; other site 1048834003676 catalytic site [active] 1048834003677 domain IV; other site 1048834003678 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1048834003679 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1048834003680 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1048834003681 Glucose inhibited division protein A; Region: GIDA; pfam01134 1048834003682 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1048834003683 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1048834003684 active site 1048834003685 DNA binding site [nucleotide binding] 1048834003686 Int/Topo IB signature motif; other site 1048834003687 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1048834003688 active site 1048834003689 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1048834003690 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1048834003691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834003692 Walker A motif; other site 1048834003693 ATP binding site [chemical binding]; other site 1048834003694 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1048834003695 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1048834003696 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1048834003697 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1048834003698 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 1048834003699 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1048834003700 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 1048834003701 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1048834003702 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1048834003703 FliG C-terminal domain; Region: FliG_C; pfam01706 1048834003704 Flagellar assembly protein FliH; Region: FliH; pfam02108 1048834003705 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 1048834003706 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1048834003707 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1048834003708 Walker A motif/ATP binding site; other site 1048834003709 Walker B motif; other site 1048834003710 MgtE intracellular N domain; Region: MgtE_N; cl15244 1048834003711 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1048834003712 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1048834003713 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1048834003714 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 1048834003715 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1048834003716 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1048834003717 Flagellar protein (FlbD); Region: FlbD; pfam06289 1048834003718 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1048834003719 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1048834003720 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1048834003721 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1048834003722 flagellar motor switch protein; Validated; Region: PRK08119 1048834003723 CheC-like family; Region: CheC; pfam04509 1048834003724 CheC-like family; Region: CheC; pfam04509 1048834003725 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1048834003726 Response regulator receiver domain; Region: Response_reg; pfam00072 1048834003727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834003728 active site 1048834003729 phosphorylation site [posttranslational modification] 1048834003730 intermolecular recognition site; other site 1048834003731 dimerization interface [polypeptide binding]; other site 1048834003732 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1048834003733 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1048834003734 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1048834003735 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1048834003736 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1048834003737 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1048834003738 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1048834003739 FHIPEP family; Region: FHIPEP; pfam00771 1048834003740 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1048834003741 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1048834003742 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1048834003743 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1048834003744 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1048834003745 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1048834003746 CheB methylesterase; Region: CheB_methylest; pfam01339 1048834003747 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1048834003748 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1048834003749 putative binding surface; other site 1048834003750 active site 1048834003751 P2 response regulator binding domain; Region: P2; pfam07194 1048834003752 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1048834003753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834003754 ATP binding site [chemical binding]; other site 1048834003755 Mg2+ binding site [ion binding]; other site 1048834003756 G-X-G motif; other site 1048834003757 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1048834003758 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1048834003759 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1048834003760 CheC-like family; Region: CheC; pfam04509 1048834003761 CheC-like family; Region: CheC; pfam04509 1048834003762 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1048834003763 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1048834003764 rRNA interaction site [nucleotide binding]; other site 1048834003765 S8 interaction site; other site 1048834003766 putative laminin-1 binding site; other site 1048834003767 elongation factor Ts; Reviewed; Region: tsf; PRK12332 1048834003768 UBA/TS-N domain; Region: UBA; pfam00627 1048834003769 Elongation factor TS; Region: EF_TS; pfam00889 1048834003770 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1048834003771 putative nucleotide binding site [chemical binding]; other site 1048834003772 uridine monophosphate binding site [chemical binding]; other site 1048834003773 homohexameric interface [polypeptide binding]; other site 1048834003774 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1048834003775 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1048834003776 hinge region; other site 1048834003777 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1048834003778 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1048834003779 catalytic residue [active] 1048834003780 putative FPP diphosphate binding site; other site 1048834003781 putative FPP binding hydrophobic cleft; other site 1048834003782 dimer interface [polypeptide binding]; other site 1048834003783 putative IPP diphosphate binding site; other site 1048834003784 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1048834003785 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1048834003786 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1048834003787 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1048834003788 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1048834003789 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1048834003790 RIP metalloprotease RseP; Region: TIGR00054 1048834003791 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1048834003792 active site 1048834003793 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1048834003794 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1048834003795 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1048834003796 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1048834003797 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1048834003798 generic binding surface II; other site 1048834003799 generic binding surface I; other site 1048834003800 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1048834003801 active site 1048834003802 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1048834003803 active site 1048834003804 catalytic site [active] 1048834003805 substrate binding site [chemical binding]; other site 1048834003806 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1048834003807 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1048834003808 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1048834003809 active site 1048834003810 metal binding site [ion binding]; metal-binding site 1048834003811 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1048834003812 Prephenate dehydratase; Region: PDT; pfam00800 1048834003813 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1048834003814 putative L-Phe binding site [chemical binding]; other site 1048834003815 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1048834003816 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1048834003817 G1 box; other site 1048834003818 putative GEF interaction site [polypeptide binding]; other site 1048834003819 GTP/Mg2+ binding site [chemical binding]; other site 1048834003820 Switch I region; other site 1048834003821 G2 box; other site 1048834003822 G3 box; other site 1048834003823 Switch II region; other site 1048834003824 G4 box; other site 1048834003825 G5 box; other site 1048834003826 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1048834003827 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1048834003828 Sm and related proteins; Region: Sm_like; cl00259 1048834003829 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1048834003830 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1048834003831 putative oligomer interface [polypeptide binding]; other site 1048834003832 putative RNA binding site [nucleotide binding]; other site 1048834003833 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1048834003834 NusA N-terminal domain; Region: NusA_N; pfam08529 1048834003835 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1048834003836 RNA binding site [nucleotide binding]; other site 1048834003837 homodimer interface [polypeptide binding]; other site 1048834003838 NusA-like KH domain; Region: KH_5; pfam13184 1048834003839 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1048834003840 G-X-X-G motif; other site 1048834003841 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1048834003842 putative RNA binding cleft [nucleotide binding]; other site 1048834003843 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1048834003844 translation initiation factor IF-2; Region: IF-2; TIGR00487 1048834003845 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1048834003846 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1048834003847 G1 box; other site 1048834003848 putative GEF interaction site [polypeptide binding]; other site 1048834003849 GTP/Mg2+ binding site [chemical binding]; other site 1048834003850 Switch I region; other site 1048834003851 G2 box; other site 1048834003852 G3 box; other site 1048834003853 Switch II region; other site 1048834003854 G4 box; other site 1048834003855 G5 box; other site 1048834003856 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1048834003857 Translation-initiation factor 2; Region: IF-2; pfam11987 1048834003858 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1048834003859 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1048834003860 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1048834003861 DHH family; Region: DHH; pfam01368 1048834003862 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 1048834003863 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1048834003864 RNA binding site [nucleotide binding]; other site 1048834003865 active site 1048834003866 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1048834003867 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1048834003868 active site 1048834003869 Riboflavin kinase; Region: Flavokinase; pfam01687 1048834003870 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1048834003871 dimerization interface [polypeptide binding]; other site 1048834003872 putative active site pocket [active] 1048834003873 putative catalytic residue [active] 1048834003874 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1048834003875 16S/18S rRNA binding site [nucleotide binding]; other site 1048834003876 S13e-L30e interaction site [polypeptide binding]; other site 1048834003877 25S rRNA binding site [nucleotide binding]; other site 1048834003878 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1048834003879 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1048834003880 RNase E interface [polypeptide binding]; other site 1048834003881 trimer interface [polypeptide binding]; other site 1048834003882 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1048834003883 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1048834003884 RNase E interface [polypeptide binding]; other site 1048834003885 trimer interface [polypeptide binding]; other site 1048834003886 active site 1048834003887 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1048834003888 putative nucleic acid binding region [nucleotide binding]; other site 1048834003889 G-X-X-G motif; other site 1048834003890 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1048834003891 RNA binding site [nucleotide binding]; other site 1048834003892 domain interface; other site 1048834003893 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1048834003894 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1048834003895 NodB motif; other site 1048834003896 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1048834003897 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1048834003898 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1048834003899 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1048834003900 trimer interface [polypeptide binding]; other site 1048834003901 active site 1048834003902 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1048834003903 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1048834003904 NAD binding site [chemical binding]; other site 1048834003905 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1048834003906 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1048834003907 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1048834003908 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1048834003909 aspartate kinase I; Reviewed; Region: PRK08210 1048834003910 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1048834003911 nucleotide binding site [chemical binding]; other site 1048834003912 substrate binding site [chemical binding]; other site 1048834003913 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1048834003914 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1048834003915 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1048834003916 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1048834003917 dimer interface [polypeptide binding]; other site 1048834003918 active site 1048834003919 catalytic residue [active] 1048834003920 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1048834003921 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1048834003922 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1048834003923 putative RNA binding site [nucleotide binding]; other site 1048834003924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834003925 S-adenosylmethionine binding site [chemical binding]; other site 1048834003926 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1048834003927 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1048834003928 active site 1048834003929 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1048834003930 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1048834003931 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1048834003932 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1048834003933 tetrameric interface [polypeptide binding]; other site 1048834003934 NAD binding site [chemical binding]; other site 1048834003935 catalytic residues [active] 1048834003936 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1048834003937 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1048834003938 substrate binding site [chemical binding]; other site 1048834003939 oxyanion hole (OAH) forming residues; other site 1048834003940 trimer interface [polypeptide binding]; other site 1048834003941 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1048834003942 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1048834003943 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1048834003944 active site 1048834003945 acyl-activating enzyme (AAE) consensus motif; other site 1048834003946 putative CoA binding site [chemical binding]; other site 1048834003947 AMP binding site [chemical binding]; other site 1048834003948 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1048834003949 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1048834003950 dimer interface [polypeptide binding]; other site 1048834003951 active site 1048834003952 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1048834003953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048834003954 NAD(P) binding site [chemical binding]; other site 1048834003955 active site 1048834003956 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1048834003957 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1048834003958 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1048834003959 NAD binding site [chemical binding]; other site 1048834003960 Phe binding site; other site 1048834003961 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1048834003962 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1048834003963 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1048834003964 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1048834003965 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1048834003966 active site 1048834003967 YlzJ-like protein; Region: YlzJ; pfam14035 1048834003968 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1048834003969 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1048834003970 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1048834003971 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1048834003972 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1048834003973 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1048834003974 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834003975 non-specific DNA binding site [nucleotide binding]; other site 1048834003976 salt bridge; other site 1048834003977 sequence-specific DNA binding site [nucleotide binding]; other site 1048834003978 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1048834003979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1048834003980 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1048834003981 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1048834003982 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1048834003983 competence damage-inducible protein A; Provisional; Region: PRK00549 1048834003984 putative MPT binding site; other site 1048834003985 Competence-damaged protein; Region: CinA; pfam02464 1048834003986 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1048834003987 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1048834003988 ATP binding site [chemical binding]; other site 1048834003989 Mg++ binding site [ion binding]; other site 1048834003990 motif III; other site 1048834003991 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048834003992 nucleotide binding region [chemical binding]; other site 1048834003993 ATP-binding site [chemical binding]; other site 1048834003994 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 1048834003995 RNA binding site [nucleotide binding]; other site 1048834003996 recombinase A; Provisional; Region: recA; PRK09354 1048834003997 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1048834003998 hexamer interface [polypeptide binding]; other site 1048834003999 Walker A motif; other site 1048834004000 ATP binding site [chemical binding]; other site 1048834004001 Walker B motif; other site 1048834004002 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1048834004003 phosphodiesterase; Provisional; Region: PRK12704 1048834004004 uncharacterized domain HDIG; Region: HDIG; TIGR00277 1048834004005 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1048834004006 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1048834004007 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1048834004008 active site 1048834004009 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1048834004010 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1048834004011 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1048834004012 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 1048834004013 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1048834004014 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 1048834004015 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1048834004016 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048834004017 FeS/SAM binding site; other site 1048834004018 TRAM domain; Region: TRAM; pfam01938 1048834004019 Protein of unknown function (DUF964); Region: DUF964; pfam06133 1048834004020 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1048834004021 MutS domain I; Region: MutS_I; pfam01624 1048834004022 MutS domain II; Region: MutS_II; pfam05188 1048834004023 MutS domain III; Region: MutS_III; pfam05192 1048834004024 MutS domain V; Region: MutS_V; pfam00488 1048834004025 Walker A/P-loop; other site 1048834004026 ATP binding site [chemical binding]; other site 1048834004027 Q-loop/lid; other site 1048834004028 ABC transporter signature motif; other site 1048834004029 Walker B; other site 1048834004030 D-loop; other site 1048834004031 H-loop/switch region; other site 1048834004032 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1048834004033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834004034 ATP binding site [chemical binding]; other site 1048834004035 Mg2+ binding site [ion binding]; other site 1048834004036 G-X-G motif; other site 1048834004037 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1048834004038 ATP binding site [chemical binding]; other site 1048834004039 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1048834004040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834004041 S-adenosylmethionine binding site [chemical binding]; other site 1048834004042 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1048834004043 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1048834004044 bacterial Hfq-like; Region: Hfq; cd01716 1048834004045 hexamer interface [polypeptide binding]; other site 1048834004046 Sm1 motif; other site 1048834004047 RNA binding site [nucleotide binding]; other site 1048834004048 Sm2 motif; other site 1048834004049 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834004050 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1048834004051 Phosphotyrosyl phosphatase activator (PTPA) is also known as protein phosphatase 2A (PP2A) phosphatase activator. PTPA is an essential, well conserved protein that stimulates the tyrosyl phosphatase activity of PP2A. It also reactivates the serine...; Region: PTPA; cl03888 1048834004052 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1048834004053 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1048834004054 Integrase core domain; Region: rve; pfam00665 1048834004055 transposase/IS protein; Provisional; Region: PRK09183 1048834004056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834004057 Walker A motif; other site 1048834004058 ATP binding site [chemical binding]; other site 1048834004059 Walker B motif; other site 1048834004060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1048834004061 Transposase; Region: HTH_Tnp_1; pfam01527 1048834004062 potential frameshift: common BLAST hit: gi|379009134|ref|YP_005258585.1| transposase IS3/IS911 family protein 1048834004063 HTH-like domain; Region: HTH_21; pfam13276 1048834004064 Integrase core domain; Region: rve; pfam00665 1048834004065 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1048834004066 Integrase core domain; Region: rve_3; pfam13683 1048834004067 Integrase core domain; Region: rve; pfam00665 1048834004068 isocitrate dehydrogenase; Validated; Region: PRK09222 1048834004069 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1048834004070 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1048834004071 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1048834004072 Spore germination protein; Region: Spore_permease; cl17796 1048834004073 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1048834004074 UDP-glucose 4-epimerase; Region: PLN02240 1048834004075 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1048834004076 NAD binding site [chemical binding]; other site 1048834004077 homodimer interface [polypeptide binding]; other site 1048834004078 active site 1048834004079 substrate binding site [chemical binding]; other site 1048834004080 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1048834004081 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1048834004082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1048834004083 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1048834004084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834004085 Walker A motif; other site 1048834004086 ATP binding site [chemical binding]; other site 1048834004087 Walker B motif; other site 1048834004088 arginine finger; other site 1048834004089 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1048834004090 G2 box; other site 1048834004091 Switch I region; other site 1048834004092 G3 box; other site 1048834004093 Switch II region; other site 1048834004094 GTP/Mg2+ binding site [chemical binding]; other site 1048834004095 G4 box; other site 1048834004096 G5 box; other site 1048834004097 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1048834004098 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1048834004099 HflX GTPase family; Region: HflX; cd01878 1048834004100 G1 box; other site 1048834004101 GTP/Mg2+ binding site [chemical binding]; other site 1048834004102 Switch I region; other site 1048834004103 G2 box; other site 1048834004104 G3 box; other site 1048834004105 Switch II region; other site 1048834004106 G4 box; other site 1048834004107 G5 box; other site 1048834004108 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1048834004109 Aluminium resistance protein; Region: Alum_res; pfam06838 1048834004110 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1048834004111 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1048834004112 DNA binding residues [nucleotide binding] 1048834004113 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1048834004114 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1048834004115 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1048834004116 Gamma subunit of transcription initiation factor IIA, N-terminal helical domain; Region: TFIIA_gamma_N; cl03508 1048834004117 TFIIA subunit interface [polypeptide binding]; other site 1048834004118 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1048834004119 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1048834004120 ligand binding site [chemical binding]; other site 1048834004121 dimerization interface [polypeptide binding]; other site 1048834004122 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1048834004123 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1048834004124 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1048834004125 KduI/IolB family; Region: KduI; pfam04962 1048834004126 altronate oxidoreductase; Provisional; Region: PRK03643 1048834004127 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1048834004128 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1048834004129 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1048834004130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834004131 putative substrate translocation pore; other site 1048834004132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834004133 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1048834004134 LexA repressor; Validated; Region: PRK00215 1048834004135 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1048834004136 Catalytic site [active] 1048834004137 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1048834004138 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048834004139 active site 1048834004140 motif I; other site 1048834004141 motif II; other site 1048834004142 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1048834004143 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1048834004144 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1048834004145 motif 1; other site 1048834004146 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1048834004147 active site 1048834004148 motif 2; other site 1048834004149 motif 3; other site 1048834004150 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1048834004151 anticodon binding site; other site 1048834004152 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1048834004153 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1048834004154 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1048834004155 FAD binding site [chemical binding]; other site 1048834004156 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1048834004157 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048834004158 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048834004159 metal binding site [ion binding]; metal-binding site 1048834004160 active site 1048834004161 I-site; other site 1048834004162 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1048834004163 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1048834004164 putative dimer interface [polypeptide binding]; other site 1048834004165 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1048834004166 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1048834004167 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1048834004168 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1048834004169 Ligand binding site [chemical binding]; other site 1048834004170 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1048834004171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1048834004172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048834004173 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1048834004174 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1048834004175 4Fe-4S binding domain; Region: Fer4; cl02805 1048834004176 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1048834004177 Cysteine-rich domain; Region: CCG; pfam02754 1048834004178 Cysteine-rich domain; Region: CCG; pfam02754 1048834004179 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1048834004180 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1048834004181 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1048834004182 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1048834004183 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1048834004184 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1048834004185 substrate binding site [chemical binding]; other site 1048834004186 oxyanion hole (OAH) forming residues; other site 1048834004187 trimer interface [polypeptide binding]; other site 1048834004188 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1048834004189 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1048834004190 dimer interface [polypeptide binding]; other site 1048834004191 active site 1048834004192 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1048834004193 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1048834004194 active site 1048834004195 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1048834004196 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1048834004197 acyl-activating enzyme (AAE) consensus motif; other site 1048834004198 putative AMP binding site [chemical binding]; other site 1048834004199 putative active site [active] 1048834004200 putative CoA binding site [chemical binding]; other site 1048834004201 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1048834004202 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1048834004203 CoenzymeA binding site [chemical binding]; other site 1048834004204 subunit interaction site [polypeptide binding]; other site 1048834004205 PHB binding site; other site 1048834004206 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 1048834004207 ATP cone domain; Region: ATP-cone; pfam03477 1048834004208 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1048834004209 active site 1048834004210 dimer interface [polypeptide binding]; other site 1048834004211 catalytic residues [active] 1048834004212 effector binding site; other site 1048834004213 R2 peptide binding site; other site 1048834004214 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1048834004215 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1048834004216 dimer interface [polypeptide binding]; other site 1048834004217 putative radical transfer pathway; other site 1048834004218 diiron center [ion binding]; other site 1048834004219 tyrosyl radical; other site 1048834004220 Amino acid permease; Region: AA_permease_2; pfam13520 1048834004221 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1048834004222 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1048834004223 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1048834004224 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1048834004225 EamA-like transporter family; Region: EamA; pfam00892 1048834004226 EamA-like transporter family; Region: EamA; pfam00892 1048834004227 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1048834004228 HTH domain; Region: HTH_11; pfam08279 1048834004229 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1048834004230 FOG: CBS domain [General function prediction only]; Region: COG0517 1048834004231 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1048834004232 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1048834004233 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1048834004234 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1048834004235 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1048834004236 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1048834004237 putative active site [active] 1048834004238 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1048834004239 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 1048834004240 hypothetical protein; Provisional; Region: PRK09262 1048834004241 hypothetical protein; Validated; Region: PRK06201 1048834004242 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1048834004243 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1048834004244 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1048834004245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048834004246 DNA-binding site [nucleotide binding]; DNA binding site 1048834004247 FCD domain; Region: FCD; pfam07729 1048834004248 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1048834004249 active site 1048834004250 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 1048834004251 tetramer interface [polypeptide binding]; other site 1048834004252 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1048834004253 active site 1048834004254 metal binding site [ion binding]; metal-binding site 1048834004255 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1048834004256 Amidohydrolase; Region: Amidohydro_2; pfam04909 1048834004257 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1048834004258 active site 1 [active] 1048834004259 dimer interface [polypeptide binding]; other site 1048834004260 hexamer interface [polypeptide binding]; other site 1048834004261 active site 2 [active] 1048834004262 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1048834004263 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1048834004264 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1048834004265 active site 1048834004266 catalytic residues [active] 1048834004267 metal binding site [ion binding]; metal-binding site 1048834004268 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1048834004269 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1048834004270 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1048834004271 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1048834004272 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1048834004273 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 1048834004274 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1048834004275 NAD binding site [chemical binding]; other site 1048834004276 catalytic residues [active] 1048834004277 Class III extradiol dioxygenases with similarity to homoprotocatechuate 2,3-dioxygenase, which catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD_like; cd07362 1048834004278 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1048834004279 putative active site [active] 1048834004280 putative metal binding site [ion binding]; other site 1048834004281 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1048834004282 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1048834004283 Bacterial transcriptional regulator; Region: IclR; pfam01614 1048834004284 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1048834004285 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1048834004286 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1048834004287 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1048834004288 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1048834004289 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 1048834004290 active site 1048834004291 metal-binding site 1048834004292 glutamine synthetase, type I; Region: GlnA; TIGR00653 1048834004293 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1048834004294 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1048834004295 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 1048834004296 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1048834004297 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1048834004298 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1048834004299 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1048834004300 dimer interface [polypeptide binding]; other site 1048834004301 putative tRNA-binding site [nucleotide binding]; other site 1048834004302 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1048834004303 nucleophilic elbow; other site 1048834004304 catalytic triad; other site 1048834004305 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1048834004306 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1048834004307 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1048834004308 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1048834004309 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1048834004310 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1048834004311 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1048834004312 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1048834004313 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1048834004314 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1048834004315 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1048834004316 Dimer interface [polypeptide binding]; other site 1048834004317 anticodon binding site; other site 1048834004318 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1048834004319 homodimer interface [polypeptide binding]; other site 1048834004320 motif 1; other site 1048834004321 motif 2; other site 1048834004322 active site 1048834004323 motif 3; other site 1048834004324 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1048834004325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834004326 Walker A motif; other site 1048834004327 ATP binding site [chemical binding]; other site 1048834004328 Walker B motif; other site 1048834004329 arginine finger; other site 1048834004330 Peptidase family M41; Region: Peptidase_M41; pfam01434 1048834004331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1048834004332 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1048834004333 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1048834004334 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1048834004335 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 1048834004336 active site 1048834004337 putative substrate binding pocket [chemical binding]; other site 1048834004338 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1048834004339 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1048834004340 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1048834004341 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1048834004342 nucleotide binding site [chemical binding]; other site 1048834004343 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1048834004344 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1048834004345 active site 1048834004346 DNA binding site [nucleotide binding] 1048834004347 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1048834004348 DNA binding site [nucleotide binding] 1048834004349 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1048834004350 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1048834004351 putative DNA binding site [nucleotide binding]; other site 1048834004352 putative homodimer interface [polypeptide binding]; other site 1048834004353 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1048834004354 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1048834004355 active site 1048834004356 catalytic site [active] 1048834004357 substrate binding site [chemical binding]; other site 1048834004358 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1048834004359 ATP binding site [chemical binding]; other site 1048834004360 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048834004361 putative Mg++ binding site [ion binding]; other site 1048834004362 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1048834004363 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1048834004364 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1048834004365 putative DNA binding site [nucleotide binding]; other site 1048834004366 putative Zn2+ binding site [ion binding]; other site 1048834004367 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1048834004368 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1048834004369 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1048834004370 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1048834004371 active site 1048834004372 NTP binding site [chemical binding]; other site 1048834004373 metal binding triad [ion binding]; metal-binding site 1048834004374 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1048834004375 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1048834004376 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1048834004377 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1048834004378 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1048834004379 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1048834004380 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1048834004381 homodimer interface [polypeptide binding]; other site 1048834004382 metal binding site [ion binding]; metal-binding site 1048834004383 potential frameshift: common BLAST hit: gi|258511626|ref|YP_003185060.1| sporulation integral membrane protein YlbJ 1048834004384 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1048834004385 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1048834004386 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1048834004387 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1048834004388 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1048834004389 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1048834004390 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1048834004391 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1048834004392 hypothetical protein; Provisional; Region: PRK03636 1048834004393 UPF0302 domain; Region: UPF0302; pfam08864 1048834004394 A short protein domain of unknown function; Region: IDEAL; smart00914 1048834004395 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1048834004396 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1048834004397 prephenate dehydrogenase; Validated; Region: PRK08507 1048834004398 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1048834004399 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1048834004400 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1048834004401 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1048834004402 substrate binding site [chemical binding]; other site 1048834004403 active site 1048834004404 catalytic residues [active] 1048834004405 heterodimer interface [polypeptide binding]; other site 1048834004406 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1048834004407 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1048834004408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834004409 catalytic residue [active] 1048834004410 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1048834004411 active site 1048834004412 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1048834004413 active site 1048834004414 ribulose/triose binding site [chemical binding]; other site 1048834004415 phosphate binding site [ion binding]; other site 1048834004416 substrate (anthranilate) binding pocket [chemical binding]; other site 1048834004417 product (indole) binding pocket [chemical binding]; other site 1048834004418 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1048834004419 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1048834004420 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1048834004421 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1048834004422 homotrimer interaction site [polypeptide binding]; other site 1048834004423 active site 1048834004424 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1048834004425 active site 1048834004426 dimer interface [polypeptide binding]; other site 1048834004427 metal binding site [ion binding]; metal-binding site 1048834004428 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1048834004429 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1048834004430 Tetramer interface [polypeptide binding]; other site 1048834004431 active site 1048834004432 FMN-binding site [chemical binding]; other site 1048834004433 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1048834004434 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1048834004435 metal binding site [ion binding]; metal-binding site 1048834004436 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1048834004437 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1048834004438 oligomer interface [polypeptide binding]; other site 1048834004439 active site 1048834004440 metal binding site [ion binding]; metal-binding site 1048834004441 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1048834004442 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1048834004443 oligomer interface [polypeptide binding]; other site 1048834004444 active site 1048834004445 metal binding site [ion binding]; metal-binding site 1048834004446 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1048834004447 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1048834004448 active site 1048834004449 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048834004450 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048834004451 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1048834004452 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1048834004453 catalytic residue [active] 1048834004454 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1048834004455 metal ion-dependent adhesion site (MIDAS); other site 1048834004456 MoxR-like ATPases [General function prediction only]; Region: COG0714 1048834004457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834004458 Walker A motif; other site 1048834004459 ATP binding site [chemical binding]; other site 1048834004460 Walker B motif; other site 1048834004461 arginine finger; other site 1048834004462 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1048834004463 E3 interaction surface; other site 1048834004464 lipoyl attachment site [posttranslational modification]; other site 1048834004465 Transglycosylase; Region: Transgly; pfam00912 1048834004466 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1048834004467 FOG: CBS domain [General function prediction only]; Region: COG0517 1048834004468 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1048834004469 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1048834004470 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1048834004471 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1048834004472 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1048834004473 active site 1048834004474 nucleophile elbow; other site 1048834004475 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1048834004476 active site 1048834004477 multimer interface [polypeptide binding]; other site 1048834004478 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1048834004479 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1048834004480 substrate binding pocket [chemical binding]; other site 1048834004481 chain length determination region; other site 1048834004482 substrate-Mg2+ binding site; other site 1048834004483 catalytic residues [active] 1048834004484 aspartate-rich region 1; other site 1048834004485 active site lid residues [active] 1048834004486 aspartate-rich region 2; other site 1048834004487 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1048834004488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834004489 S-adenosylmethionine binding site [chemical binding]; other site 1048834004490 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1048834004491 transcription attenuation protein MtrB; Provisional; Region: PRK13251 1048834004492 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 1048834004493 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1048834004494 putative NAD(P) binding site [chemical binding]; other site 1048834004495 catalytic Zn binding site [ion binding]; other site 1048834004496 structural Zn binding site [ion binding]; other site 1048834004497 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1048834004498 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1048834004499 G1 box; other site 1048834004500 GTP/Mg2+ binding site [chemical binding]; other site 1048834004501 G2 box; other site 1048834004502 Switch I region; other site 1048834004503 G3 box; other site 1048834004504 Switch II region; other site 1048834004505 G5 box; other site 1048834004506 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1048834004507 lipoyl attachment site [posttranslational modification]; other site 1048834004508 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1048834004509 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1048834004510 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1048834004511 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1048834004512 GTP-binding protein Der; Reviewed; Region: PRK00093 1048834004513 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1048834004514 G1 box; other site 1048834004515 GTP/Mg2+ binding site [chemical binding]; other site 1048834004516 Switch I region; other site 1048834004517 G2 box; other site 1048834004518 Switch II region; other site 1048834004519 G3 box; other site 1048834004520 G4 box; other site 1048834004521 G5 box; other site 1048834004522 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1048834004523 G1 box; other site 1048834004524 GTP/Mg2+ binding site [chemical binding]; other site 1048834004525 Switch I region; other site 1048834004526 G2 box; other site 1048834004527 G3 box; other site 1048834004528 Switch II region; other site 1048834004529 G4 box; other site 1048834004530 G5 box; other site 1048834004531 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1048834004532 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1048834004533 RNA binding site [nucleotide binding]; other site 1048834004534 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1048834004535 RNA binding site [nucleotide binding]; other site 1048834004536 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1048834004537 RNA binding site [nucleotide binding]; other site 1048834004538 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1048834004539 RNA binding site [nucleotide binding]; other site 1048834004540 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1048834004541 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1048834004542 putative acyl-acceptor binding pocket; other site 1048834004543 cytidylate kinase; Provisional; Region: cmk; PRK00023 1048834004544 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1048834004545 CMP-binding site; other site 1048834004546 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1048834004547 PilZ domain; Region: PilZ; pfam07238 1048834004548 germination protein YpeB; Region: spore_YpeB; TIGR02889 1048834004549 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1048834004550 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1048834004551 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1048834004552 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1048834004553 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1048834004554 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1048834004555 NAD(P) binding site [chemical binding]; other site 1048834004556 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 1048834004557 catabolite control protein A; Region: ccpA; TIGR01481 1048834004558 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048834004559 DNA binding site [nucleotide binding] 1048834004560 domain linker motif; other site 1048834004561 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1048834004562 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1048834004563 Part of AAA domain; Region: AAA_19; pfam13245 1048834004564 Family description; Region: UvrD_C_2; pfam13538 1048834004565 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 1048834004566 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1048834004567 putative active site [active] 1048834004568 putative metal binding site [ion binding]; other site 1048834004569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834004570 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1048834004571 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1048834004572 Protease prsW family; Region: PrsW-protease; pfam13367 1048834004573 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1048834004574 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1048834004575 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834004576 non-specific DNA binding site [nucleotide binding]; other site 1048834004577 salt bridge; other site 1048834004578 sequence-specific DNA binding site [nucleotide binding]; other site 1048834004579 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1048834004580 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048834004581 dimerization interface [polypeptide binding]; other site 1048834004582 PAS domain; Region: PAS; smart00091 1048834004583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048834004584 dimer interface [polypeptide binding]; other site 1048834004585 phosphorylation site [posttranslational modification] 1048834004586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834004587 ATP binding site [chemical binding]; other site 1048834004588 Mg2+ binding site [ion binding]; other site 1048834004589 G-X-G motif; other site 1048834004590 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1048834004591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834004592 active site 1048834004593 phosphorylation site [posttranslational modification] 1048834004594 intermolecular recognition site; other site 1048834004595 dimerization interface [polypeptide binding]; other site 1048834004596 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048834004597 DNA binding site [nucleotide binding] 1048834004598 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1048834004599 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1048834004600 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1048834004601 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1048834004602 RNA binding surface [nucleotide binding]; other site 1048834004603 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1048834004604 active site 1048834004605 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1048834004606 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1048834004607 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1048834004608 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1048834004609 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1048834004610 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1048834004611 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1048834004612 Peptidase family M50; Region: Peptidase_M50; pfam02163 1048834004613 active site 1048834004614 putative substrate binding region [chemical binding]; other site 1048834004615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1048834004616 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 1048834004617 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1048834004618 stage V sporulation protein AD; Validated; Region: PRK08304 1048834004619 stage V sporulation protein AD; Provisional; Region: PRK12404 1048834004620 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1048834004621 sporulation sigma factor SigF; Validated; Region: PRK05572 1048834004622 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048834004623 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1048834004624 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048834004625 DNA binding residues [nucleotide binding] 1048834004626 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1048834004627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834004628 ATP binding site [chemical binding]; other site 1048834004629 Mg2+ binding site [ion binding]; other site 1048834004630 G-X-G motif; other site 1048834004631 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1048834004632 anti sigma factor interaction site; other site 1048834004633 regulatory phosphorylation site [posttranslational modification]; other site 1048834004634 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1048834004635 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834004636 non-specific DNA binding site [nucleotide binding]; other site 1048834004637 salt bridge; other site 1048834004638 sequence-specific DNA binding site [nucleotide binding]; other site 1048834004639 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1048834004640 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1048834004641 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1048834004642 phosphopentomutase; Provisional; Region: PRK05362 1048834004643 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1048834004644 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1048834004645 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1048834004646 active site 1048834004647 Int/Topo IB signature motif; other site 1048834004648 RNHCP domain; Region: RNHCP; pfam12647 1048834004649 Integral membrane protein DUF95; Region: DUF95; cl00572 1048834004650 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 1048834004651 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1048834004652 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1048834004653 dimer interface [polypeptide binding]; other site 1048834004654 ADP-ribose binding site [chemical binding]; other site 1048834004655 active site 1048834004656 nudix motif; other site 1048834004657 metal binding site [ion binding]; metal-binding site 1048834004658 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1048834004659 peptidase T-like protein; Region: PepT-like; TIGR01883 1048834004660 metal binding site [ion binding]; metal-binding site 1048834004661 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1048834004662 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1048834004663 lipoyl synthase; Provisional; Region: PRK05481 1048834004664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048834004665 FeS/SAM binding site; other site 1048834004666 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 1048834004667 dimer interface [polypeptide binding]; other site 1048834004668 putative active site [active] 1048834004669 trimer interface [polypeptide binding]; other site 1048834004670 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1048834004671 MoaE interaction surface [polypeptide binding]; other site 1048834004672 MoeB interaction surface [polypeptide binding]; other site 1048834004673 thiocarboxylated glycine; other site 1048834004674 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1048834004675 MoaE homodimer interface [polypeptide binding]; other site 1048834004676 MoaD interaction [polypeptide binding]; other site 1048834004677 active site residues [active] 1048834004678 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1048834004679 active site 1048834004680 Predicted permease; Region: DUF318; cl17795 1048834004681 Protein of unknown function DUF45; Region: DUF45; pfam01863 1048834004682 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1048834004683 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1048834004684 metal binding site [ion binding]; metal-binding site 1048834004685 dimer interface [polypeptide binding]; other site 1048834004686 Chlorite dismutase; Region: Chlor_dismutase; cl01280 1048834004687 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1048834004688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834004689 active site 1048834004690 phosphorylation site [posttranslational modification] 1048834004691 intermolecular recognition site; other site 1048834004692 dimerization interface [polypeptide binding]; other site 1048834004693 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1048834004694 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1048834004695 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1048834004696 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1048834004697 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1048834004698 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1048834004699 Walker A/P-loop; other site 1048834004700 ATP binding site [chemical binding]; other site 1048834004701 Q-loop/lid; other site 1048834004702 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1048834004703 ABC transporter signature motif; other site 1048834004704 Walker B; other site 1048834004705 D-loop; other site 1048834004706 H-loop/switch region; other site 1048834004707 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1048834004708 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1048834004709 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1048834004710 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1048834004711 RNA binding surface [nucleotide binding]; other site 1048834004712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834004713 S-adenosylmethionine binding site [chemical binding]; other site 1048834004714 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1048834004715 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1048834004716 substrate binding pocket [chemical binding]; other site 1048834004717 chain length determination region; other site 1048834004718 substrate-Mg2+ binding site; other site 1048834004719 catalytic residues [active] 1048834004720 aspartate-rich region 1; other site 1048834004721 active site lid residues [active] 1048834004722 aspartate-rich region 2; other site 1048834004723 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 1048834004724 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1048834004725 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1048834004726 generic binding surface II; other site 1048834004727 generic binding surface I; other site 1048834004728 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1048834004729 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1048834004730 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1048834004731 homodimer interface [polypeptide binding]; other site 1048834004732 NADP binding site [chemical binding]; other site 1048834004733 substrate binding site [chemical binding]; other site 1048834004734 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1048834004735 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1048834004736 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048834004737 Glycoprotease family; Region: Peptidase_M22; pfam00814 1048834004738 transcription antitermination factor NusB; Region: nusB; TIGR01951 1048834004739 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 1048834004740 Asp23 family; Region: Asp23; cl00574 1048834004741 Asp23 family; Region: Asp23; pfam03780 1048834004742 Asp23 family; Region: Asp23; pfam03780 1048834004743 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1048834004744 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1048834004745 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1048834004746 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1048834004747 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1048834004748 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1048834004749 carboxyltransferase (CT) interaction site; other site 1048834004750 biotinylation site [posttranslational modification]; other site 1048834004751 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1048834004752 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1048834004753 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1048834004754 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; cl17562 1048834004755 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 1048834004756 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 1048834004757 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1048834004758 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; pfam09548 1048834004759 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1048834004760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1048834004761 Walker A motif; other site 1048834004762 ATP binding site [chemical binding]; other site 1048834004763 Walker B motif; other site 1048834004764 elongation factor P; Validated; Region: PRK00529 1048834004765 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1048834004766 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1048834004767 RNA binding site [nucleotide binding]; other site 1048834004768 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1048834004769 RNA binding site [nucleotide binding]; other site 1048834004770 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1048834004771 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1048834004772 trimer interface [polypeptide binding]; other site 1048834004773 active site 1048834004774 dimer interface [polypeptide binding]; other site 1048834004775 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1048834004776 catalytic core [active] 1048834004777 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1048834004778 tetramer interface [polypeptide binding]; other site 1048834004779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834004780 catalytic residue [active] 1048834004781 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1048834004782 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1048834004783 tetramer interface [polypeptide binding]; other site 1048834004784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834004785 catalytic residue [active] 1048834004786 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1048834004787 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1048834004788 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1048834004789 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 1048834004790 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1048834004791 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048834004792 ATP binding site [chemical binding]; other site 1048834004793 putative Mg++ binding site [ion binding]; other site 1048834004794 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048834004795 nucleotide binding region [chemical binding]; other site 1048834004796 ATP-binding site [chemical binding]; other site 1048834004797 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1048834004798 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1048834004799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834004800 Walker A motif; other site 1048834004801 ATP binding site [chemical binding]; other site 1048834004802 Walker B motif; other site 1048834004803 shikimate kinase; Reviewed; Region: aroK; PRK00131 1048834004804 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1048834004805 ADP binding site [chemical binding]; other site 1048834004806 magnesium binding site [ion binding]; other site 1048834004807 putative shikimate binding site; other site 1048834004808 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1048834004809 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1048834004810 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1048834004811 putative active site pocket [active] 1048834004812 dimerization interface [polypeptide binding]; other site 1048834004813 putative catalytic residue [active] 1048834004814 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 1048834004815 Germination protease; Region: Peptidase_A25; cl04057 1048834004816 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1048834004817 hypothetical protein; Provisional; Region: PHA02765 1048834004818 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1048834004819 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1048834004820 conjugal transfer ATPase TrbB; Provisional; Region: PRK13894 1048834004821 Walker A motif; other site 1048834004822 ATP binding site [chemical binding]; other site 1048834004823 Walker B motif; other site 1048834004824 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1048834004825 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1048834004826 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1048834004827 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048834004828 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1048834004829 Mg binding site [ion binding]; other site 1048834004830 nucleotide binding site [chemical binding]; other site 1048834004831 putative protofilament interface [polypeptide binding]; other site 1048834004832 AAA domain; Region: AAA_31; pfam13614 1048834004833 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1048834004834 P-loop; other site 1048834004835 Magnesium ion binding site [ion binding]; other site 1048834004836 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1048834004837 IHF - DNA interface [nucleotide binding]; other site 1048834004838 IHF dimer interface [polypeptide binding]; other site 1048834004839 Replication-relaxation; Region: Replic_Relax; pfam13814 1048834004840 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1048834004841 Domain of unknown function DUF87; Region: DUF87; pfam01935 1048834004842 AAA-like domain; Region: AAA_10; pfam12846 1048834004843 Walker A motif; other site 1048834004844 Phospholipid methyltransferase; Region: PEMT; cl17370 1048834004845 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1048834004846 Zn2+ binding site [ion binding]; other site 1048834004847 Mg2+ binding site [ion binding]; other site 1048834004848 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048834004849 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048834004850 metal binding site [ion binding]; metal-binding site 1048834004851 active site 1048834004852 I-site; other site 1048834004853 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1048834004854 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1048834004855 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1048834004856 catalytic residue [active] 1048834004857 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1048834004858 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1048834004859 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1048834004860 TcpE family; Region: TcpE; pfam12648 1048834004861 Prophage antirepressor [Transcription]; Region: COG3617 1048834004862 BRO family, N-terminal domain; Region: Bro-N; smart01040 1048834004863 AAA-like domain; Region: AAA_10; pfam12846 1048834004864 positive control sigma-like factor; Validated; Region: PRK06930 1048834004865 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1048834004866 DNA binding residues [nucleotide binding] 1048834004867 BRO family, N-terminal domain; Region: Bro-N; smart01040 1048834004868 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1048834004869 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1048834004870 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1048834004871 ParB-like nuclease domain; Region: ParB; smart00470 1048834004872 ParB-like nuclease domain; Region: ParB; smart00470 1048834004873 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1048834004874 ParB-like nuclease domain; Region: ParBc; pfam02195 1048834004875 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1048834004876 putative active site pocket [active] 1048834004877 dimerization interface [polypeptide binding]; other site 1048834004878 putative catalytic residue [active] 1048834004879 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1048834004880 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048834004881 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1048834004882 Predicted helicase [General function prediction only]; Region: COG4889 1048834004883 Predicted helicase [General function prediction only]; Region: COG4889 1048834004884 Restriction endonuclease; Region: Mrr_cat; pfam04471 1048834004885 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048834004886 ATP binding site [chemical binding]; other site 1048834004887 putative Mg++ binding site [ion binding]; other site 1048834004888 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048834004889 nucleotide binding region [chemical binding]; other site 1048834004890 ATP-binding site [chemical binding]; other site 1048834004891 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1048834004892 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1048834004893 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1048834004894 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1048834004895 dimerization interface [polypeptide binding]; other site 1048834004896 putative active site pocket [active] 1048834004897 putative catalytic residue [active] 1048834004898 YolD-like protein; Region: YolD; pfam08863 1048834004899 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1048834004900 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1048834004901 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1048834004902 Cation efflux family; Region: Cation_efflux; cl00316 1048834004903 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1048834004904 putative dimer interface [polypeptide binding]; other site 1048834004905 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1048834004906 ligand binding site [chemical binding]; other site 1048834004907 Zn binding site [ion binding]; other site 1048834004908 transposase/IS protein; Provisional; Region: PRK09183 1048834004909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1048834004910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1048834004911 Integrase core domain; Region: rve; pfam00665 1048834004912 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1048834004913 Transposase; Region: HTH_Tnp_1; pfam01527 1048834004914 putative transposase OrfB; Reviewed; Region: PHA02517 1048834004915 HTH-like domain; Region: HTH_21; pfam13276 1048834004916 Integrase core domain; Region: rve; pfam00665 1048834004917 Integrase core domain; Region: rve_3; pfam13683 1048834004918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048834004919 active site 1048834004920 amino acid transporter; Region: 2A0306; TIGR00909 1048834004921 Transposase domain (DUF772); Region: DUF772; pfam05598 1048834004922 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834004923 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1048834004924 Homeodomain-like domain; Region: HTH_23; cl17451 1048834004925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834004926 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1048834004927 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1048834004928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834004929 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1048834004930 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1048834004931 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1048834004932 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834004933 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1048834004934 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1048834004935 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1048834004936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834004937 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1048834004938 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1048834004939 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1048834004940 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1048834004941 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1048834004942 DinB superfamily; Region: DinB_2; pfam12867 1048834004943 DinB family; Region: DinB; cl17821 1048834004944 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1048834004945 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1048834004946 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 1048834004947 Cupin domain; Region: Cupin_2; pfam07883 1048834004948 Cupin domain; Region: Cupin_2; pfam07883 1048834004949 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1048834004950 active site 1048834004951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834004952 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048834004953 putative substrate translocation pore; other site 1048834004954 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1048834004955 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1048834004956 acyl-activating enzyme (AAE) consensus motif; other site 1048834004957 AMP binding site [chemical binding]; other site 1048834004958 active site 1048834004959 CoA binding site [chemical binding]; other site 1048834004960 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1048834004961 Thiolase, N-terminal domain; Region: Thiolase_N; pfam00108 1048834004962 dimer interface [polypeptide binding]; other site 1048834004963 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1048834004964 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1048834004965 substrate binding site [chemical binding]; other site 1048834004966 oxyanion hole (OAH) forming residues; other site 1048834004967 trimer interface [polypeptide binding]; other site 1048834004968 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1048834004969 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1048834004970 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1048834004971 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1048834004972 Transposase; Region: HTH_Tnp_1; pfam01527 1048834004973 putative transposase OrfB; Reviewed; Region: PHA02517 1048834004974 HTH-like domain; Region: HTH_21; pfam13276 1048834004975 Integrase core domain; Region: rve; pfam00665 1048834004976 Integrase core domain; Region: rve_3; pfam13683 1048834004977 putative transposase OrfB; Reviewed; Region: PHA02517 1048834004978 HTH-like domain; Region: HTH_21; pfam13276 1048834004979 Integrase core domain; Region: rve; pfam00665 1048834004980 Integrase core domain; Region: rve_3; pfam13683 1048834004981 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834004982 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834004983 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1048834004984 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1048834004985 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1048834004986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834004987 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1048834004988 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1048834004989 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048834004990 DNA binding residues [nucleotide binding] 1048834004991 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1048834004992 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1048834004993 exodeoxyribonuclease X; Provisional; Region: PRK07983 1048834004994 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1048834004995 active site 1048834004996 catalytic site [active] 1048834004997 substrate binding site [chemical binding]; other site 1048834004998 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 1048834004999 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 1048834005000 Protein of unknown function (DUF669); Region: DUF669; pfam05037 1048834005001 DNA polymerase III subunit beta; Validated; Region: PRK05643 1048834005002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1048834005003 putative DNA binding surface [nucleotide binding]; other site 1048834005004 dimer interface [polypeptide binding]; other site 1048834005005 beta-clamp/translesion DNA polymerase binding surface; other site 1048834005006 beta-clamp/clamp loader binding surface; other site 1048834005007 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 1048834005008 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1048834005009 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1048834005010 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1048834005011 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048834005012 ATP binding site [chemical binding]; other site 1048834005013 putative Mg++ binding site [ion binding]; other site 1048834005014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048834005015 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1048834005016 nucleotide binding region [chemical binding]; other site 1048834005017 ATP-binding site [chemical binding]; other site 1048834005018 Transposase domain (DUF772); Region: DUF772; pfam05598 1048834005019 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834005020 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1048834005021 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1048834005022 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1048834005023 Prophage antirepressor [Transcription]; Region: COG3617 1048834005024 BRO family, N-terminal domain; Region: Bro-N; smart01040 1048834005025 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1048834005026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834005027 non-specific DNA binding site [nucleotide binding]; other site 1048834005028 salt bridge; other site 1048834005029 sequence-specific DNA binding site [nucleotide binding]; other site 1048834005030 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1048834005031 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834005032 sequence-specific DNA binding site [nucleotide binding]; other site 1048834005033 salt bridge; other site 1048834005034 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1048834005035 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834005036 non-specific DNA binding site [nucleotide binding]; other site 1048834005037 salt bridge; other site 1048834005038 sequence-specific DNA binding site [nucleotide binding]; other site 1048834005039 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1048834005040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834005041 non-specific DNA binding site [nucleotide binding]; other site 1048834005042 salt bridge; other site 1048834005043 sequence-specific DNA binding site [nucleotide binding]; other site 1048834005044 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1048834005045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834005046 non-specific DNA binding site [nucleotide binding]; other site 1048834005047 salt bridge; other site 1048834005048 sequence-specific DNA binding site [nucleotide binding]; other site 1048834005049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834005050 non-specific DNA binding site [nucleotide binding]; other site 1048834005051 salt bridge; other site 1048834005052 sequence-specific DNA binding site [nucleotide binding]; other site 1048834005053 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1048834005054 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1048834005055 Int/Topo IB signature motif; other site 1048834005056 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1048834005057 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1048834005058 MULE transposase domain; Region: MULE; pfam10551 1048834005059 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1048834005060 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1048834005061 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1048834005062 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1048834005063 Walker A motif; other site 1048834005064 ATP binding site [chemical binding]; other site 1048834005065 Walker B motif; other site 1048834005066 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 1048834005067 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1048834005068 GTP1/OBG; Region: GTP1_OBG; pfam01018 1048834005069 Obg GTPase; Region: Obg; cd01898 1048834005070 G1 box; other site 1048834005071 GTP/Mg2+ binding site [chemical binding]; other site 1048834005072 Switch I region; other site 1048834005073 G2 box; other site 1048834005074 G3 box; other site 1048834005075 Switch II region; other site 1048834005076 G4 box; other site 1048834005077 G5 box; other site 1048834005078 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1048834005079 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1048834005080 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1048834005081 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1048834005082 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1048834005083 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1048834005084 Peptidase family M50; Region: Peptidase_M50; pfam02163 1048834005085 active site 1048834005086 putative substrate binding region [chemical binding]; other site 1048834005087 Peptidase family M23; Region: Peptidase_M23; pfam01551 1048834005088 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1048834005089 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1048834005090 P-loop; other site 1048834005091 ADP binding residues [chemical binding]; other site 1048834005092 Switch I; other site 1048834005093 Switch II; other site 1048834005094 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1048834005095 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1048834005096 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1048834005097 rod shape-determining protein MreC; Provisional; Region: PRK13922 1048834005098 rod shape-determining protein MreC; Region: MreC; pfam04085 1048834005099 rod shape-determining protein MreB; Provisional; Region: PRK13927 1048834005100 MreB and similar proteins; Region: MreB_like; cd10225 1048834005101 nucleotide binding site [chemical binding]; other site 1048834005102 Mg binding site [ion binding]; other site 1048834005103 putative protofilament interaction site [polypeptide binding]; other site 1048834005104 RodZ interaction site [polypeptide binding]; other site 1048834005105 hypothetical protein; Reviewed; Region: PRK00024 1048834005106 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1048834005107 helix-hairpin-helix signature motif; other site 1048834005108 active site 1048834005109 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1048834005110 MPN+ (JAMM) motif; other site 1048834005111 Zinc-binding site [ion binding]; other site 1048834005112 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1048834005113 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1048834005114 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1048834005115 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1048834005116 G5 domain; Region: G5; pfam07501 1048834005117 3D domain; Region: 3D; cl01439 1048834005118 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1048834005119 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1048834005120 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1048834005121 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1048834005122 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1048834005123 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1048834005124 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1048834005125 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1048834005126 HIGH motif; other site 1048834005127 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1048834005128 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1048834005129 active site 1048834005130 KMSKS motif; other site 1048834005131 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1048834005132 tRNA binding surface [nucleotide binding]; other site 1048834005133 anticodon binding site; other site 1048834005134 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1048834005135 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1048834005136 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1048834005137 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1048834005138 inhibitor-cofactor binding pocket; inhibition site 1048834005139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834005140 catalytic residue [active] 1048834005141 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1048834005142 dimer interface [polypeptide binding]; other site 1048834005143 active site 1048834005144 Schiff base residues; other site 1048834005145 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1048834005146 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1048834005147 active site 1048834005148 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1048834005149 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1048834005150 domain interfaces; other site 1048834005151 active site 1048834005152 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1048834005153 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1048834005154 tRNA; other site 1048834005155 putative tRNA binding site [nucleotide binding]; other site 1048834005156 putative NADP binding site [chemical binding]; other site 1048834005157 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1048834005158 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1048834005159 G1 box; other site 1048834005160 GTP/Mg2+ binding site [chemical binding]; other site 1048834005161 Switch I region; other site 1048834005162 G2 box; other site 1048834005163 G3 box; other site 1048834005164 Switch II region; other site 1048834005165 G4 box; other site 1048834005166 G5 box; other site 1048834005167 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1048834005168 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1048834005169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834005170 Walker A motif; other site 1048834005171 ATP binding site [chemical binding]; other site 1048834005172 Walker B motif; other site 1048834005173 arginine finger; other site 1048834005174 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1048834005175 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1048834005176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834005177 Walker A motif; other site 1048834005178 ATP binding site [chemical binding]; other site 1048834005179 Walker B motif; other site 1048834005180 arginine finger; other site 1048834005181 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1048834005182 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1048834005183 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1048834005184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834005185 Walker A motif; other site 1048834005186 ATP binding site [chemical binding]; other site 1048834005187 Walker B motif; other site 1048834005188 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1048834005189 Clp protease; Region: CLP_protease; pfam00574 1048834005190 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1048834005191 oligomer interface [polypeptide binding]; other site 1048834005192 active site residues [active] 1048834005193 trigger factor; Provisional; Region: tig; PRK01490 1048834005194 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1048834005195 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1048834005196 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1048834005197 active site 1048834005198 dimerization interface [polypeptide binding]; other site 1048834005199 glutamate racemase; Provisional; Region: PRK00865 1048834005200 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1048834005201 MarR family; Region: MarR; pfam01047 1048834005202 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1048834005203 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1048834005204 active site 1048834005205 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1048834005206 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1048834005207 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 1048834005208 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1048834005209 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048834005210 DNA binding residues [nucleotide binding] 1048834005211 dimerization interface [polypeptide binding]; other site 1048834005212 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 1048834005213 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048834005214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834005215 homodimer interface [polypeptide binding]; other site 1048834005216 catalytic residue [active] 1048834005217 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1048834005218 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048834005219 FeS/SAM binding site; other site 1048834005220 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1048834005221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048834005222 DNA-binding site [nucleotide binding]; DNA binding site 1048834005223 UTRA domain; Region: UTRA; pfam07702 1048834005224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834005225 putative substrate translocation pore; other site 1048834005226 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048834005227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834005228 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1048834005229 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1048834005230 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1048834005231 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1048834005232 L-aspartate oxidase; Provisional; Region: PRK06175 1048834005233 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1048834005234 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1048834005235 putative Iron-sulfur protein interface [polypeptide binding]; other site 1048834005236 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1048834005237 proximal heme binding site [chemical binding]; other site 1048834005238 distal heme binding site [chemical binding]; other site 1048834005239 putative dimer interface [polypeptide binding]; other site 1048834005240 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1048834005241 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1048834005242 GIY-YIG motif/motif A; other site 1048834005243 active site 1048834005244 catalytic site [active] 1048834005245 putative DNA binding site [nucleotide binding]; other site 1048834005246 metal binding site [ion binding]; metal-binding site 1048834005247 UvrB/uvrC motif; Region: UVR; pfam02151 1048834005248 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1048834005249 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1048834005250 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1048834005251 HIGH motif; other site 1048834005252 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1048834005253 active site 1048834005254 KMSKS motif; other site 1048834005255 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1048834005256 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048834005257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834005258 homodimer interface [polypeptide binding]; other site 1048834005259 catalytic residue [active] 1048834005260 Protein of unknown function (DUF502); Region: DUF502; cl01107 1048834005261 calcium/proton exchanger (cax); Region: cax; TIGR00378 1048834005262 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1048834005263 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1048834005264 Protein of unknown function DUF72; Region: DUF72; pfam01904 1048834005265 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1048834005266 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1048834005267 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1048834005268 Ligand binding site; other site 1048834005269 Putative Catalytic site; other site 1048834005270 DXD motif; other site 1048834005271 Predicted membrane protein [Function unknown]; Region: COG2246 1048834005272 GtrA-like protein; Region: GtrA; pfam04138 1048834005273 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1048834005274 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1048834005275 Mediator complex subunit MED14; Region: Med14; pfam08638 1048834005276 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1048834005277 MarR family; Region: MarR_2; pfam12802 1048834005278 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1048834005279 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1048834005280 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1048834005281 active site 1048834005282 dimer interface [polypeptide binding]; other site 1048834005283 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1048834005284 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1048834005285 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1048834005286 putative active site [active] 1048834005287 catalytic site [active] 1048834005288 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1048834005289 putative active site [active] 1048834005290 catalytic site [active] 1048834005291 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1048834005292 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1048834005293 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1048834005294 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1048834005295 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1048834005296 effector binding site; other site 1048834005297 dimer interface [polypeptide binding]; other site 1048834005298 active site 1048834005299 TSCPD domain; Region: TSCPD; pfam12637 1048834005300 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1048834005301 ATP cone domain; Region: ATP-cone; pfam03477 1048834005302 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1048834005303 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048834005304 active site 1048834005305 motif I; other site 1048834005306 motif II; other site 1048834005307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048834005308 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1048834005309 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1048834005310 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1048834005311 Ligand binding site; other site 1048834005312 Putative Catalytic site; other site 1048834005313 DXD motif; other site 1048834005314 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1048834005315 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1048834005316 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1048834005317 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1048834005318 beta-galactosidase; Region: BGL; TIGR03356 1048834005319 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1048834005320 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048834005321 Walker A/P-loop; other site 1048834005322 ATP binding site [chemical binding]; other site 1048834005323 Q-loop/lid; other site 1048834005324 ABC transporter signature motif; other site 1048834005325 Walker B; other site 1048834005326 D-loop; other site 1048834005327 H-loop/switch region; other site 1048834005328 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1048834005329 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1048834005330 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048834005331 Walker A/P-loop; other site 1048834005332 ATP binding site [chemical binding]; other site 1048834005333 Q-loop/lid; other site 1048834005334 ABC transporter signature motif; other site 1048834005335 Walker B; other site 1048834005336 D-loop; other site 1048834005337 H-loop/switch region; other site 1048834005338 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1048834005339 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1048834005340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834005341 dimer interface [polypeptide binding]; other site 1048834005342 conserved gate region; other site 1048834005343 putative PBP binding loops; other site 1048834005344 ABC-ATPase subunit interface; other site 1048834005345 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1048834005346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834005347 dimer interface [polypeptide binding]; other site 1048834005348 conserved gate region; other site 1048834005349 putative PBP binding loops; other site 1048834005350 ABC-ATPase subunit interface; other site 1048834005351 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 1048834005352 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1048834005353 substrate binding site [chemical binding]; other site 1048834005354 Ferredoxin [Energy production and conversion]; Region: COG1146 1048834005355 4Fe-4S binding domain; Region: Fer4; pfam00037 1048834005356 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1048834005357 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1048834005358 Walker A/P-loop; other site 1048834005359 ATP binding site [chemical binding]; other site 1048834005360 Q-loop/lid; other site 1048834005361 ABC transporter signature motif; other site 1048834005362 Walker B; other site 1048834005363 D-loop; other site 1048834005364 H-loop/switch region; other site 1048834005365 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1048834005366 PhoU domain; Region: PhoU; pfam01895 1048834005367 PhoU domain; Region: PhoU; pfam01895 1048834005368 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048834005369 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048834005370 NlpC/P60 family; Region: NLPC_P60; pfam00877 1048834005371 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1048834005372 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 1048834005373 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1048834005374 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1048834005375 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 1048834005376 NodB motif; other site 1048834005377 putative active site [active] 1048834005378 putative catalytic site [active] 1048834005379 putative Zn binding site [ion binding]; other site 1048834005380 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1048834005381 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1048834005382 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1048834005383 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1048834005384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834005385 dimer interface [polypeptide binding]; other site 1048834005386 conserved gate region; other site 1048834005387 ABC-ATPase subunit interface; other site 1048834005388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834005389 dimer interface [polypeptide binding]; other site 1048834005390 conserved gate region; other site 1048834005391 putative PBP binding loops; other site 1048834005392 ABC-ATPase subunit interface; other site 1048834005393 PBP superfamily domain; Region: PBP_like_2; cl17296 1048834005394 Transposase domain (DUF772); Region: DUF772; pfam05598 1048834005395 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834005396 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1048834005397 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1048834005398 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1048834005399 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1048834005400 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1048834005401 dimer interface [polypeptide binding]; other site 1048834005402 tetramer interface [polypeptide binding]; other site 1048834005403 PYR/PP interface [polypeptide binding]; other site 1048834005404 TPP binding site [chemical binding]; other site 1048834005405 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1048834005406 TPP-binding site; other site 1048834005407 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 1048834005408 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1048834005409 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1048834005410 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1048834005411 acyl-activating enzyme (AAE) consensus motif; other site 1048834005412 putative AMP binding site [chemical binding]; other site 1048834005413 putative active site [active] 1048834005414 putative CoA binding site [chemical binding]; other site 1048834005415 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1048834005416 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1048834005417 substrate binding site [chemical binding]; other site 1048834005418 oxyanion hole (OAH) forming residues; other site 1048834005419 trimer interface [polypeptide binding]; other site 1048834005420 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1048834005421 UbiA prenyltransferase family; Region: UbiA; pfam01040 1048834005422 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1048834005423 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 1048834005424 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1048834005425 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1048834005426 catalytic loop [active] 1048834005427 iron binding site [ion binding]; other site 1048834005428 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1048834005429 4Fe-4S binding domain; Region: Fer4; pfam00037 1048834005430 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1048834005431 [4Fe-4S] binding site [ion binding]; other site 1048834005432 molybdopterin cofactor binding site; other site 1048834005433 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1048834005434 molybdopterin cofactor binding site; other site 1048834005435 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1048834005436 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1048834005437 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1048834005438 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1048834005439 EamA-like transporter family; Region: EamA; pfam00892 1048834005440 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1048834005441 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1048834005442 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1048834005443 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1048834005444 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1048834005445 dimer interface [polypeptide binding]; other site 1048834005446 substrate binding site [chemical binding]; other site 1048834005447 ATP binding site [chemical binding]; other site 1048834005448 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1048834005449 substrate binding site [chemical binding]; other site 1048834005450 multimerization interface [polypeptide binding]; other site 1048834005451 ATP binding site [chemical binding]; other site 1048834005452 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1048834005453 thiamine phosphate binding site [chemical binding]; other site 1048834005454 active site 1048834005455 pyrophosphate binding site [ion binding]; other site 1048834005456 Spore germination protein; Region: Spore_permease; cl17796 1048834005457 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1048834005458 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1048834005459 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1048834005460 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1048834005461 active site 1048834005462 FMN binding site [chemical binding]; other site 1048834005463 substrate binding site [chemical binding]; other site 1048834005464 3Fe-4S cluster binding site [ion binding]; other site 1048834005465 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1048834005466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834005467 Walker A/P-loop; other site 1048834005468 ATP binding site [chemical binding]; other site 1048834005469 Q-loop/lid; other site 1048834005470 ABC transporter signature motif; other site 1048834005471 Walker B; other site 1048834005472 D-loop; other site 1048834005473 H-loop/switch region; other site 1048834005474 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1048834005475 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048834005476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834005477 Walker A/P-loop; other site 1048834005478 ATP binding site [chemical binding]; other site 1048834005479 Q-loop/lid; other site 1048834005480 ABC transporter signature motif; other site 1048834005481 Walker B; other site 1048834005482 D-loop; other site 1048834005483 H-loop/switch region; other site 1048834005484 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1048834005485 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1048834005486 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1048834005487 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1048834005488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834005489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048834005490 putative substrate translocation pore; other site 1048834005491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834005492 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1048834005493 MarR family; Region: MarR; pfam01047 1048834005494 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1048834005495 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1048834005496 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1048834005497 Walker A/P-loop; other site 1048834005498 ATP binding site [chemical binding]; other site 1048834005499 Q-loop/lid; other site 1048834005500 ABC transporter signature motif; other site 1048834005501 Walker B; other site 1048834005502 D-loop; other site 1048834005503 H-loop/switch region; other site 1048834005504 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1048834005505 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1048834005506 ABC-ATPase subunit interface; other site 1048834005507 dimer interface [polypeptide binding]; other site 1048834005508 putative PBP binding regions; other site 1048834005509 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1048834005510 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1048834005511 intersubunit interface [polypeptide binding]; other site 1048834005512 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1048834005513 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1048834005514 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1048834005515 active site pocket [active] 1048834005516 putative dimer interface [polypeptide binding]; other site 1048834005517 putative cataytic base [active] 1048834005518 Predicted transcriptional regulators [Transcription]; Region: COG1733 1048834005519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1048834005520 dimerization interface [polypeptide binding]; other site 1048834005521 putative DNA binding site [nucleotide binding]; other site 1048834005522 putative Zn2+ binding site [ion binding]; other site 1048834005523 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1048834005524 active site 1048834005525 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 1048834005526 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048834005527 FeS/SAM binding site; other site 1048834005528 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1048834005529 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048834005530 motif II; other site 1048834005531 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1048834005532 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1048834005533 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1048834005534 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1048834005535 Homoserine O-succinyltransferase; Region: HTS; pfam04204 1048834005536 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1048834005537 proposed active site lysine [active] 1048834005538 conserved cys residue [active] 1048834005539 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1048834005540 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1048834005541 tetramerization interface [polypeptide binding]; other site 1048834005542 active site 1048834005543 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1048834005544 active site 1048834005545 catalytic triad [active] 1048834005546 oxyanion hole [active] 1048834005547 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1048834005548 metal-binding site [ion binding] 1048834005549 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834005550 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1048834005551 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1048834005552 Spore germination protein; Region: Spore_permease; cl17796 1048834005553 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 1048834005554 PAS fold; Region: PAS_4; pfam08448 1048834005555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048834005556 dimer interface [polypeptide binding]; other site 1048834005557 phosphorylation site [posttranslational modification] 1048834005558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834005559 ATP binding site [chemical binding]; other site 1048834005560 Mg2+ binding site [ion binding]; other site 1048834005561 G-X-G motif; other site 1048834005562 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1048834005563 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1048834005564 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1048834005565 active site 1048834005566 FMN binding site [chemical binding]; other site 1048834005567 substrate binding site [chemical binding]; other site 1048834005568 homotetramer interface [polypeptide binding]; other site 1048834005569 catalytic residue [active] 1048834005570 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1048834005571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048834005572 dimer interface [polypeptide binding]; other site 1048834005573 phosphorylation site [posttranslational modification] 1048834005574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834005575 ATP binding site [chemical binding]; other site 1048834005576 Mg2+ binding site [ion binding]; other site 1048834005577 G-X-G motif; other site 1048834005578 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1048834005579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834005580 active site 1048834005581 phosphorylation site [posttranslational modification] 1048834005582 intermolecular recognition site; other site 1048834005583 dimerization interface [polypeptide binding]; other site 1048834005584 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048834005585 DNA binding site [nucleotide binding] 1048834005586 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1048834005587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048834005588 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1048834005589 Coenzyme A binding pocket [chemical binding]; other site 1048834005590 active site 1048834005591 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1048834005592 metal binding site [ion binding]; metal-binding site 1048834005593 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1048834005594 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1048834005595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1048834005596 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1048834005597 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1048834005598 Family of unknown function (DUF633); Region: DUF633; pfam04816 1048834005599 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1048834005600 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1048834005601 putative active site [active] 1048834005602 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1048834005603 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1048834005604 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1048834005605 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048834005606 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1048834005607 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048834005608 DNA binding residues [nucleotide binding] 1048834005609 DNA primase; Validated; Region: dnaG; PRK05667 1048834005610 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1048834005611 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1048834005612 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1048834005613 active site 1048834005614 metal binding site [ion binding]; metal-binding site 1048834005615 interdomain interaction site; other site 1048834005616 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1048834005617 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1048834005618 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1048834005619 Recombination protein O N terminal; Region: RecO_N; pfam11967 1048834005620 Recombination protein O C terminal; Region: RecO_C; pfam02565 1048834005621 YqzL-like protein; Region: YqzL; pfam14006 1048834005622 GTPase Era; Reviewed; Region: era; PRK00089 1048834005623 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1048834005624 G1 box; other site 1048834005625 GTP/Mg2+ binding site [chemical binding]; other site 1048834005626 Switch I region; other site 1048834005627 G2 box; other site 1048834005628 Switch II region; other site 1048834005629 G3 box; other site 1048834005630 G4 box; other site 1048834005631 G5 box; other site 1048834005632 KH domain; Region: KH_2; pfam07650 1048834005633 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1048834005634 metal-binding heat shock protein; Provisional; Region: PRK00016 1048834005635 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1048834005636 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1048834005637 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1048834005638 Zn2+ binding site [ion binding]; other site 1048834005639 Mg2+ binding site [ion binding]; other site 1048834005640 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1048834005641 PhoH-like protein; Region: PhoH; pfam02562 1048834005642 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1048834005643 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1048834005644 YabP family; Region: YabP; cl06766 1048834005645 Yqey-like protein; Region: YqeY; pfam09424 1048834005646 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1048834005647 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1048834005648 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1048834005649 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1048834005650 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1048834005651 active site 1048834005652 Ap6A binding site [chemical binding]; other site 1048834005653 nudix motif; other site 1048834005654 metal binding site [ion binding]; metal-binding site 1048834005655 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1048834005656 intersubunit interface [polypeptide binding]; other site 1048834005657 active site 1048834005658 catalytic residue [active] 1048834005659 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1048834005660 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1048834005661 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048834005662 FeS/SAM binding site; other site 1048834005663 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1048834005664 RNA methyltransferase, RsmE family; Region: TIGR00046 1048834005665 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1048834005666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834005667 S-adenosylmethionine binding site [chemical binding]; other site 1048834005668 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 1048834005669 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1048834005670 HSP70 interaction site [polypeptide binding]; other site 1048834005671 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1048834005672 substrate binding site [polypeptide binding]; other site 1048834005673 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1048834005674 Zn binding sites [ion binding]; other site 1048834005675 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1048834005676 dimer interface [polypeptide binding]; other site 1048834005677 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1048834005678 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1048834005679 nucleotide binding site [chemical binding]; other site 1048834005680 NEF interaction site [polypeptide binding]; other site 1048834005681 SBD interface [polypeptide binding]; other site 1048834005682 heat shock protein GrpE; Provisional; Region: PRK14140 1048834005683 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1048834005684 dimer interface [polypeptide binding]; other site 1048834005685 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1048834005686 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1048834005687 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1048834005688 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048834005689 FeS/SAM binding site; other site 1048834005690 HemN C-terminal domain; Region: HemN_C; pfam06969 1048834005691 GTP-binding protein LepA; Provisional; Region: PRK05433 1048834005692 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1048834005693 G1 box; other site 1048834005694 putative GEF interaction site [polypeptide binding]; other site 1048834005695 GTP/Mg2+ binding site [chemical binding]; other site 1048834005696 Switch I region; other site 1048834005697 G2 box; other site 1048834005698 G3 box; other site 1048834005699 Switch II region; other site 1048834005700 G4 box; other site 1048834005701 G5 box; other site 1048834005702 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1048834005703 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1048834005704 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1048834005705 Cation efflux family; Region: Cation_efflux; cl00316 1048834005706 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1048834005707 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1048834005708 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1048834005709 catalytic residue [active] 1048834005710 germination protease; Provisional; Region: PRK12362 1048834005711 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1048834005712 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1048834005713 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1048834005714 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1048834005715 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1048834005716 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048834005717 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1048834005718 Competence protein; Region: Competence; pfam03772 1048834005719 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1048834005720 SLBB domain; Region: SLBB; pfam10531 1048834005721 Helix-hairpin-helix motif; Region: HHH; pfam00633 1048834005722 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1048834005723 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1048834005724 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1048834005725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834005726 S-adenosylmethionine binding site [chemical binding]; other site 1048834005727 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1048834005728 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 1048834005729 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1048834005730 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1048834005731 active site 1048834005732 (T/H)XGH motif; other site 1048834005733 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1048834005734 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1048834005735 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1048834005736 shikimate binding site; other site 1048834005737 NAD(P) binding site [chemical binding]; other site 1048834005738 ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597 1048834005739 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1048834005740 GTP/Mg2+ binding site [chemical binding]; other site 1048834005741 G4 box; other site 1048834005742 G5 box; other site 1048834005743 G1 box; other site 1048834005744 Switch I region; other site 1048834005745 G2 box; other site 1048834005746 G3 box; other site 1048834005747 Switch II region; other site 1048834005748 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1048834005749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048834005750 active site 1048834005751 motif I; other site 1048834005752 motif II; other site 1048834005753 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1048834005754 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048834005755 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048834005756 DNA binding residues [nucleotide binding] 1048834005757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1048834005758 YceG-like family; Region: YceG; pfam02618 1048834005759 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1048834005760 dimerization interface [polypeptide binding]; other site 1048834005761 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1048834005762 hypothetical protein; Provisional; Region: PRK05473 1048834005763 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1048834005764 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1048834005765 motif 1; other site 1048834005766 active site 1048834005767 motif 2; other site 1048834005768 motif 3; other site 1048834005769 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1048834005770 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1048834005771 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1048834005772 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1048834005773 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1048834005774 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1048834005775 catalytic residue [active] 1048834005776 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 1048834005777 Transcriptional regulator; Region: Rrf2; pfam02082 1048834005778 recombination factor protein RarA; Reviewed; Region: PRK13342 1048834005779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834005780 Walker A motif; other site 1048834005781 ATP binding site [chemical binding]; other site 1048834005782 Walker B motif; other site 1048834005783 arginine finger; other site 1048834005784 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1048834005785 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1048834005786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1048834005787 Probable transposase; Region: OrfB_IS605; pfam01385 1048834005788 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1048834005789 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1048834005790 arsenical pump membrane protein; Provisional; Region: PRK15445 1048834005791 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1048834005792 transmembrane helices; other site 1048834005793 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1048834005794 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1048834005795 acyl-activating enzyme (AAE) consensus motif; other site 1048834005796 AMP binding site [chemical binding]; other site 1048834005797 active site 1048834005798 CoA binding site [chemical binding]; other site 1048834005799 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1048834005800 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1048834005801 dimer interface [polypeptide binding]; other site 1048834005802 anticodon binding site; other site 1048834005803 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1048834005804 homodimer interface [polypeptide binding]; other site 1048834005805 motif 1; other site 1048834005806 active site 1048834005807 motif 2; other site 1048834005808 GAD domain; Region: GAD; pfam02938 1048834005809 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1048834005810 motif 3; other site 1048834005811 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1048834005812 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1048834005813 dimer interface [polypeptide binding]; other site 1048834005814 motif 1; other site 1048834005815 active site 1048834005816 motif 2; other site 1048834005817 motif 3; other site 1048834005818 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1048834005819 anticodon binding site; other site 1048834005820 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1048834005821 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1048834005822 inhibitor-cofactor binding pocket; inhibition site 1048834005823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834005824 catalytic residue [active] 1048834005825 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1048834005826 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1048834005827 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1048834005828 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1048834005829 Walker A/P-loop; other site 1048834005830 ATP binding site [chemical binding]; other site 1048834005831 Q-loop/lid; other site 1048834005832 ABC transporter signature motif; other site 1048834005833 Walker B; other site 1048834005834 D-loop; other site 1048834005835 H-loop/switch region; other site 1048834005836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834005837 putative substrate translocation pore; other site 1048834005838 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048834005839 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1048834005840 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1048834005841 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1048834005842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1048834005843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834005844 putative PBP binding loops; other site 1048834005845 dimer interface [polypeptide binding]; other site 1048834005846 ABC-ATPase subunit interface; other site 1048834005847 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1048834005848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834005849 dimer interface [polypeptide binding]; other site 1048834005850 conserved gate region; other site 1048834005851 putative PBP binding loops; other site 1048834005852 ABC-ATPase subunit interface; other site 1048834005853 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1048834005854 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1048834005855 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1048834005856 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1048834005857 iron-sulfur cluster [ion binding]; other site 1048834005858 [2Fe-2S] cluster binding site [ion binding]; other site 1048834005859 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1048834005860 hydrophobic ligand binding site; other site 1048834005861 enoyl-CoA hydratase; Provisional; Region: PRK07657 1048834005862 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1048834005863 substrate binding site [chemical binding]; other site 1048834005864 oxyanion hole (OAH) forming residues; other site 1048834005865 trimer interface [polypeptide binding]; other site 1048834005866 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1048834005867 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1048834005868 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1048834005869 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1048834005870 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1048834005871 active site 1048834005872 catalytic residues [active] 1048834005873 metal binding site [ion binding]; metal-binding site 1048834005874 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1048834005875 carboxyltransferase (CT) interaction site; other site 1048834005876 biotinylation site [posttranslational modification]; other site 1048834005877 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1048834005878 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1048834005879 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1048834005880 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1048834005881 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1048834005882 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1048834005883 active site 1048834005884 acetyl-CoA synthetase; Provisional; Region: PRK00174 1048834005885 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1048834005886 acyl-activating enzyme (AAE) consensus motif; other site 1048834005887 AMP binding site [chemical binding]; other site 1048834005888 active site 1048834005889 CoA binding site [chemical binding]; other site 1048834005890 putative acyltransferase; Provisional; Region: PRK05790 1048834005891 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1048834005892 dimer interface [polypeptide binding]; other site 1048834005893 active site 1048834005894 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1048834005895 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1048834005896 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1048834005897 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1048834005898 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1048834005899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834005900 S-adenosylmethionine binding site [chemical binding]; other site 1048834005901 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1048834005902 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1048834005903 classical (c) SDRs; Region: SDR_c; cd05233 1048834005904 NAD(P) binding site [chemical binding]; other site 1048834005905 active site 1048834005906 MFS/sugar transport protein; Region: MFS_2; pfam13347 1048834005907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834005908 putative substrate translocation pore; other site 1048834005909 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1048834005910 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048834005911 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048834005912 active site 1048834005913 catalytic tetrad [active] 1048834005914 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 1048834005915 MPT binding site; other site 1048834005916 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1048834005917 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1048834005918 active site 1048834005919 tetramer interface; other site 1048834005920 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1048834005921 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048834005922 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1048834005923 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048834005924 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1048834005925 NlpC/P60 family; Region: NLPC_P60; pfam00877 1048834005926 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1048834005927 Part of AAA domain; Region: AAA_19; pfam13245 1048834005928 Family description; Region: UvrD_C_2; pfam13538 1048834005929 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1048834005930 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1048834005931 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1048834005932 benzoate transport; Region: 2A0115; TIGR00895 1048834005933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834005934 putative substrate translocation pore; other site 1048834005935 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1048834005936 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1048834005937 FMN binding site [chemical binding]; other site 1048834005938 active site 1048834005939 catalytic residues [active] 1048834005940 substrate binding site [chemical binding]; other site 1048834005941 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1048834005942 TM2 domain; Region: TM2; cl00984 1048834005943 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1048834005944 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1048834005945 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1048834005946 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1048834005947 DNA binding site [nucleotide binding] 1048834005948 sequence specific DNA binding site [nucleotide binding]; other site 1048834005949 putative cAMP binding site [chemical binding]; other site 1048834005950 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1048834005951 FeoA domain; Region: FeoA; pfam04023 1048834005952 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1048834005953 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1048834005954 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 1048834005955 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1048834005956 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1048834005957 substrate binding site [chemical binding]; other site 1048834005958 active site 1048834005959 ferrochelatase; Provisional; Region: PRK12435 1048834005960 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1048834005961 C-terminal domain interface [polypeptide binding]; other site 1048834005962 active site 1048834005963 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1048834005964 active site 1048834005965 N-terminal domain interface [polypeptide binding]; other site 1048834005966 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1048834005967 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1048834005968 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1048834005969 hypothetical protein; Provisional; Region: PRK10621 1048834005970 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048834005971 metal binding site [ion binding]; metal-binding site 1048834005972 active site 1048834005973 I-site; other site 1048834005974 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048834005975 GAF domain; Region: GAF; pfam01590 1048834005976 GAF domain; Region: GAF_2; pfam13185 1048834005977 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1048834005978 putative active site [active] 1048834005979 dimerization interface [polypeptide binding]; other site 1048834005980 putative tRNAtyr binding site [nucleotide binding]; other site 1048834005981 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1048834005982 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1048834005983 Zn2+ binding site [ion binding]; other site 1048834005984 Mg2+ binding site [ion binding]; other site 1048834005985 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1048834005986 synthetase active site [active] 1048834005987 NTP binding site [chemical binding]; other site 1048834005988 metal binding site [ion binding]; metal-binding site 1048834005989 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1048834005990 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1048834005991 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048834005992 active site 1048834005993 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1048834005994 DHH family; Region: DHH; pfam01368 1048834005995 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 1048834005996 Cation efflux family; Region: Cation_efflux; pfam01545 1048834005997 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1048834005998 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1048834005999 Protein export membrane protein; Region: SecD_SecF; pfam02355 1048834006000 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1048834006001 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1048834006002 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1048834006003 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1048834006004 Predicted membrane protein [Function unknown]; Region: COG2323 1048834006005 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1048834006006 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1048834006007 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048834006008 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048834006009 metal binding site [ion binding]; metal-binding site 1048834006010 active site 1048834006011 I-site; other site 1048834006012 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048834006013 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048834006014 metal binding site [ion binding]; metal-binding site 1048834006015 active site 1048834006016 I-site; other site 1048834006017 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 1048834006018 Preprotein translocase subunit; Region: YajC; pfam02699 1048834006019 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1048834006020 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1048834006021 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1048834006022 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1048834006023 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1048834006024 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1048834006025 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048834006026 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1048834006027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834006028 Walker A motif; other site 1048834006029 ATP binding site [chemical binding]; other site 1048834006030 Walker B motif; other site 1048834006031 arginine finger; other site 1048834006032 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1048834006033 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1048834006034 RuvA N terminal domain; Region: RuvA_N; pfam01330 1048834006035 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1048834006036 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1048834006037 active site 1048834006038 putative DNA-binding cleft [nucleotide binding]; other site 1048834006039 dimer interface [polypeptide binding]; other site 1048834006040 hypothetical protein; Validated; Region: PRK00110 1048834006041 NAD synthetase; Provisional; Region: PRK13980 1048834006042 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1048834006043 homodimer interface [polypeptide binding]; other site 1048834006044 NAD binding pocket [chemical binding]; other site 1048834006045 ATP binding pocket [chemical binding]; other site 1048834006046 Mg binding site [ion binding]; other site 1048834006047 active-site loop [active] 1048834006048 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1048834006049 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 1048834006050 putative active site [active] 1048834006051 catalytic triad [active] 1048834006052 putative dimer interface [polypeptide binding]; other site 1048834006053 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1048834006054 active site 1048834006055 ATP binding site [chemical binding]; other site 1048834006056 Phosphotransferase enzyme family; Region: APH; pfam01636 1048834006057 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048834006058 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 1048834006059 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1048834006060 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1048834006061 active site 1048834006062 HIGH motif; other site 1048834006063 dimer interface [polypeptide binding]; other site 1048834006064 KMSKS motif; other site 1048834006065 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1048834006066 RNA binding surface [nucleotide binding]; other site 1048834006067 Transglycosylase; Region: Transgly; pfam00912 1048834006068 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1048834006069 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1048834006070 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1048834006071 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1048834006072 Walker A/P-loop; other site 1048834006073 ATP binding site [chemical binding]; other site 1048834006074 Q-loop/lid; other site 1048834006075 ABC transporter signature motif; other site 1048834006076 Walker B; other site 1048834006077 D-loop; other site 1048834006078 H-loop/switch region; other site 1048834006079 Smr domain; Region: Smr; pfam01713 1048834006080 Membrane protein of unknown function; Region: DUF360; pfam04020 1048834006081 Colicin V production protein; Region: Colicin_V; pfam02674 1048834006082 Cell division protein ZapA; Region: ZapA; pfam05164 1048834006083 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1048834006084 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1048834006085 putative tRNA-binding site [nucleotide binding]; other site 1048834006086 B3/4 domain; Region: B3_4; pfam03483 1048834006087 tRNA synthetase B5 domain; Region: B5; smart00874 1048834006088 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1048834006089 dimer interface [polypeptide binding]; other site 1048834006090 motif 1; other site 1048834006091 motif 3; other site 1048834006092 motif 2; other site 1048834006093 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1048834006094 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1048834006095 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1048834006096 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1048834006097 dimer interface [polypeptide binding]; other site 1048834006098 motif 1; other site 1048834006099 active site 1048834006100 motif 2; other site 1048834006101 motif 3; other site 1048834006102 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1048834006103 ATP-grasp domain; Region: ATP-grasp; pfam02222 1048834006104 AIR carboxylase; Region: AIRC; pfam00731 1048834006105 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1048834006106 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1048834006107 putative active site; other site 1048834006108 catalytic residue [active] 1048834006109 6-phosphofructokinase; Provisional; Region: PRK03202 1048834006110 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1048834006111 active site 1048834006112 ADP/pyrophosphate binding site [chemical binding]; other site 1048834006113 dimerization interface [polypeptide binding]; other site 1048834006114 allosteric effector site; other site 1048834006115 fructose-1,6-bisphosphate binding site; other site 1048834006116 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1048834006117 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 1048834006118 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048834006119 dimerization interface [polypeptide binding]; other site 1048834006120 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1048834006121 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1048834006122 dimer interface [polypeptide binding]; other site 1048834006123 putative CheW interface [polypeptide binding]; other site 1048834006124 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1048834006125 dimerization domain swap beta strand [polypeptide binding]; other site 1048834006126 regulatory protein interface [polypeptide binding]; other site 1048834006127 active site 1048834006128 regulatory phosphorylation site [posttranslational modification]; other site 1048834006129 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1048834006130 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1048834006131 Walker A/P-loop; other site 1048834006132 ATP binding site [chemical binding]; other site 1048834006133 Q-loop/lid; other site 1048834006134 ABC transporter signature motif; other site 1048834006135 Walker B; other site 1048834006136 D-loop; other site 1048834006137 H-loop/switch region; other site 1048834006138 TOBE domain; Region: TOBE; pfam03459 1048834006139 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1048834006140 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1048834006141 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1048834006142 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1048834006143 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1048834006144 putative NAD(P) binding site [chemical binding]; other site 1048834006145 malate:quinone oxidoreductase; Validated; Region: PRK05257 1048834006146 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1048834006147 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1048834006148 E3 interaction surface; other site 1048834006149 lipoyl attachment site [posttranslational modification]; other site 1048834006150 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1048834006151 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1048834006152 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1048834006153 TPP-binding site [chemical binding]; other site 1048834006154 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1048834006155 MoxR-like ATPases [General function prediction only]; Region: COG0714 1048834006156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834006157 Walker A motif; other site 1048834006158 ATP binding site [chemical binding]; other site 1048834006159 Walker B motif; other site 1048834006160 arginine finger; other site 1048834006161 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1048834006162 Protein of unknown function DUF58; Region: DUF58; pfam01882 1048834006163 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1048834006164 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1048834006165 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1048834006166 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1048834006167 dimerization interface [polypeptide binding]; other site 1048834006168 ligand binding site [chemical binding]; other site 1048834006169 NADP binding site [chemical binding]; other site 1048834006170 catalytic site [active] 1048834006171 Putative zinc-finger; Region: zf-HC2; pfam13490 1048834006172 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1048834006173 EamA-like transporter family; Region: EamA; pfam00892 1048834006174 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1048834006175 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1048834006176 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1048834006177 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1048834006178 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1048834006179 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1048834006180 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1048834006181 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1048834006182 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1048834006183 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1048834006184 Domain found in IF2B/IF5; Region: eIF-5_eIF-2B; cl17014 1048834006185 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1048834006186 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1048834006187 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1048834006188 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1048834006189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048834006190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1048834006191 Coenzyme A binding pocket [chemical binding]; other site 1048834006192 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1048834006193 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1048834006194 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1048834006195 dimanganese center [ion binding]; other site 1048834006196 CotJB protein; Region: CotJB; pfam12652 1048834006197 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1048834006198 Divergent PAP2 family; Region: DUF212; pfam02681 1048834006199 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1048834006200 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1048834006201 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1048834006202 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1048834006203 23S rRNA binding site [nucleotide binding]; other site 1048834006204 L21 binding site [polypeptide binding]; other site 1048834006205 L13 binding site [polypeptide binding]; other site 1048834006206 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1048834006207 translation initiation factor IF-3; Region: infC; TIGR00168 1048834006208 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1048834006209 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1048834006210 Sulphur transport; Region: Sulf_transp; pfam04143 1048834006211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834006212 S-adenosylmethionine binding site [chemical binding]; other site 1048834006213 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1048834006214 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1048834006215 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1048834006216 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1048834006217 active site 1048834006218 dimer interface [polypeptide binding]; other site 1048834006219 motif 1; other site 1048834006220 motif 2; other site 1048834006221 motif 3; other site 1048834006222 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1048834006223 anticodon binding site; other site 1048834006224 YtxC-like family; Region: YtxC; cl08500 1048834006225 oligoendopeptidase F; Region: pepF; TIGR00181 1048834006226 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1048834006227 Zn binding site [ion binding]; other site 1048834006228 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1048834006229 active site 1048834006230 catalytic residues [active] 1048834006231 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1048834006232 N- and C-terminal domain interface [polypeptide binding]; other site 1048834006233 D-xylulose kinase; Region: XylB; TIGR01312 1048834006234 active site 1048834006235 MgATP binding site [chemical binding]; other site 1048834006236 catalytic site [active] 1048834006237 metal binding site [ion binding]; metal-binding site 1048834006238 xylulose binding site [chemical binding]; other site 1048834006239 homodimer interface [polypeptide binding]; other site 1048834006240 xylose isomerase; Provisional; Region: PRK05474 1048834006241 xylose isomerase; Region: xylose_isom_A; TIGR02630 1048834006242 benzoate transport; Region: 2A0115; TIGR00895 1048834006243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834006244 putative substrate translocation pore; other site 1048834006245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834006246 putative substrate translocation pore; other site 1048834006247 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1048834006248 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1048834006249 putative active site [active] 1048834006250 putative metal binding site [ion binding]; other site 1048834006251 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1048834006252 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1048834006253 active site 1048834006254 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1048834006255 classical (c) SDRs; Region: SDR_c; cd05233 1048834006256 NAD(P) binding site [chemical binding]; other site 1048834006257 active site 1048834006258 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1048834006259 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1048834006260 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1048834006261 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1048834006262 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1048834006263 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1048834006264 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1048834006265 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 1048834006266 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1048834006267 DNA-binding site [nucleotide binding]; DNA binding site 1048834006268 RNA-binding motif; other site 1048834006269 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 1048834006270 polypeptide substrate binding site [polypeptide binding]; other site 1048834006271 active site 1048834006272 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048834006273 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048834006274 active site 1048834006275 catalytic tetrad [active] 1048834006276 arsenical pump membrane protein; Provisional; Region: PRK15445 1048834006277 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1048834006278 transmembrane helices; other site 1048834006279 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1048834006280 conserved cys residue [active] 1048834006281 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1048834006282 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 1048834006283 Na binding site [ion binding]; other site 1048834006284 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048834006285 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048834006286 active site 1048834006287 catalytic tetrad [active] 1048834006288 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1048834006289 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1048834006290 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1048834006291 aromatic arch; other site 1048834006292 DCoH dimer interaction site [polypeptide binding]; other site 1048834006293 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1048834006294 DCoH tetramer interaction site [polypeptide binding]; other site 1048834006295 substrate binding site [chemical binding]; other site 1048834006296 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1048834006297 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1048834006298 dimer interface [polypeptide binding]; other site 1048834006299 ADP-ribose binding site [chemical binding]; other site 1048834006300 active site 1048834006301 nudix motif; other site 1048834006302 metal binding site [ion binding]; metal-binding site 1048834006303 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1048834006304 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1048834006305 Rhomboid family; Region: Rhomboid; pfam01694 1048834006306 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1048834006307 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1048834006308 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1048834006309 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1048834006310 FtsX-like permease family; Region: FtsX; pfam02687 1048834006311 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1048834006312 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1048834006313 Walker A/P-loop; other site 1048834006314 ATP binding site [chemical binding]; other site 1048834006315 Q-loop/lid; other site 1048834006316 ABC transporter signature motif; other site 1048834006317 Walker B; other site 1048834006318 D-loop; other site 1048834006319 H-loop/switch region; other site 1048834006320 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1048834006321 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048834006322 FOG: CBS domain [General function prediction only]; Region: COG0517 1048834006323 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1048834006324 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1048834006325 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1048834006326 dimer interface [polypeptide binding]; other site 1048834006327 Citrate synthase; Region: Citrate_synt; pfam00285 1048834006328 active site 1048834006329 citrylCoA binding site [chemical binding]; other site 1048834006330 oxalacetate/citrate binding site [chemical binding]; other site 1048834006331 coenzyme A binding site [chemical binding]; other site 1048834006332 catalytic triad [active] 1048834006333 Predicted membrane protein [Function unknown]; Region: COG1971 1048834006334 Domain of unknown function DUF; Region: DUF204; pfam02659 1048834006335 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1048834006336 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1048834006337 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1048834006338 hypothetical protein; Provisional; Region: PRK14812 1048834006339 substrate binding site [chemical binding]; other site 1048834006340 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1048834006341 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1048834006342 substrate binding site [chemical binding]; other site 1048834006343 ligand binding site [chemical binding]; other site 1048834006344 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1048834006345 tartrate dehydrogenase; Region: TTC; TIGR02089 1048834006346 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1048834006347 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1048834006348 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1048834006349 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1048834006350 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1048834006351 putative valine binding site [chemical binding]; other site 1048834006352 dimer interface [polypeptide binding]; other site 1048834006353 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1048834006354 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1048834006355 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1048834006356 PYR/PP interface [polypeptide binding]; other site 1048834006357 dimer interface [polypeptide binding]; other site 1048834006358 TPP binding site [chemical binding]; other site 1048834006359 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1048834006360 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1048834006361 TPP-binding site [chemical binding]; other site 1048834006362 dimer interface [polypeptide binding]; other site 1048834006363 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1048834006364 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1048834006365 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1048834006366 homodimer interface [polypeptide binding]; other site 1048834006367 substrate-cofactor binding pocket; other site 1048834006368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834006369 catalytic residue [active] 1048834006370 homoserine dehydrogenase; Provisional; Region: PRK06349 1048834006371 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1048834006372 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1048834006373 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1048834006374 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1048834006375 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1048834006376 putative substrate binding site [chemical binding]; other site 1048834006377 putative ATP binding site [chemical binding]; other site 1048834006378 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1048834006379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834006380 dimer interface [polypeptide binding]; other site 1048834006381 conserved gate region; other site 1048834006382 putative PBP binding loops; other site 1048834006383 ABC-ATPase subunit interface; other site 1048834006384 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1048834006385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834006386 dimer interface [polypeptide binding]; other site 1048834006387 conserved gate region; other site 1048834006388 putative PBP binding loops; other site 1048834006389 ABC-ATPase subunit interface; other site 1048834006390 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1048834006391 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1048834006392 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1048834006393 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048834006394 DNA binding site [nucleotide binding] 1048834006395 domain linker motif; other site 1048834006396 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1048834006397 dimerization interface [polypeptide binding]; other site 1048834006398 ligand binding site [chemical binding]; other site 1048834006399 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1048834006400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834006401 non-specific DNA binding site [nucleotide binding]; other site 1048834006402 salt bridge; other site 1048834006403 sequence-specific DNA binding site [nucleotide binding]; other site 1048834006404 PBP superfamily domain; Region: PBP_like; pfam12727 1048834006405 molybdate ABC transporter periplasmic substrate-binding protein; Provisional; Region: PRK04168 1048834006406 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 1048834006407 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1048834006408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834006409 dimer interface [polypeptide binding]; other site 1048834006410 conserved gate region; other site 1048834006411 putative PBP binding loops; other site 1048834006412 ABC-ATPase subunit interface; other site 1048834006413 peroxiredoxin; Provisional; Region: PRK13189 1048834006414 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1048834006415 dimer interface [polypeptide binding]; other site 1048834006416 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1048834006417 catalytic triad [active] 1048834006418 Transcriptional regulator; Region: Rrf2; cl17282 1048834006419 Transcriptional regulator; Region: Rrf2; cl17282 1048834006420 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1048834006421 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1048834006422 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1048834006423 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1048834006424 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1048834006425 dimerization interface [polypeptide binding]; other site 1048834006426 putative active site pocket [active] 1048834006427 putative catalytic residue [active] 1048834006428 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 1048834006429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1048834006430 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1048834006431 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1048834006432 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1048834006433 Walker A motif; other site 1048834006434 ATP binding site [chemical binding]; other site 1048834006435 Walker B motif; other site 1048834006436 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1048834006437 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048834006438 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1048834006439 Mg binding site [ion binding]; other site 1048834006440 nucleotide binding site [chemical binding]; other site 1048834006441 putative protofilament interface [polypeptide binding]; other site 1048834006442 AAA domain; Region: AAA_31; pfam13614 1048834006443 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1048834006444 P-loop; other site 1048834006445 Magnesium ion binding site [ion binding]; other site 1048834006446 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1048834006447 IHF - DNA interface [nucleotide binding]; other site 1048834006448 IHF dimer interface [polypeptide binding]; other site 1048834006449 Replication-relaxation; Region: Replic_Relax; pfam13814 1048834006450 Domain of unknown function DUF87; Region: DUF87; pfam01935 1048834006451 AAA-like domain; Region: AAA_10; pfam12846 1048834006452 Phospholipid methyltransferase; Region: PEMT; cl17370 1048834006453 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1048834006454 Zn2+ binding site [ion binding]; other site 1048834006455 Mg2+ binding site [ion binding]; other site 1048834006456 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048834006457 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048834006458 metal binding site [ion binding]; metal-binding site 1048834006459 active site 1048834006460 I-site; other site 1048834006461 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1048834006462 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1048834006463 catalytic residue [active] 1048834006464 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1048834006465 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1048834006466 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1048834006467 TcpE family; Region: TcpE; pfam12648 1048834006468 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1048834006469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1048834006470 Probable transposase; Region: OrfB_IS605; pfam01385 1048834006471 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1048834006472 Prophage antirepressor [Transcription]; Region: COG3617 1048834006473 BRO family, N-terminal domain; Region: Bro-N; smart01040 1048834006474 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1048834006475 AAA-like domain; Region: AAA_10; pfam12846 1048834006476 positive control sigma-like factor; Validated; Region: PRK06930 1048834006477 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048834006478 DNA binding residues [nucleotide binding] 1048834006479 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1048834006480 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1048834006481 active site 1048834006482 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1048834006483 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1048834006484 P-loop; other site 1048834006485 Magnesium ion binding site [ion binding]; other site 1048834006486 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1048834006487 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1048834006488 ParB-like nuclease domain; Region: ParBc; pfam02195 1048834006489 YcfA-like protein; Region: YcfA; pfam07927 1048834006490 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1048834006491 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 1048834006492 Domain of unknown function (DUF955); Region: DUF955; cl01076 1048834006493 ParB-like nuclease domain; Region: ParB; smart00470 1048834006494 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1048834006495 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 1048834006496 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1048834006497 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1048834006498 cofactor binding site; other site 1048834006499 DNA binding site [nucleotide binding] 1048834006500 substrate interaction site [chemical binding]; other site 1048834006501 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1048834006502 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1048834006503 ParB-like nuclease domain; Region: ParBc; pfam02195 1048834006504 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1048834006505 putative active site pocket [active] 1048834006506 dimerization interface [polypeptide binding]; other site 1048834006507 putative catalytic residue [active] 1048834006508 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1048834006509 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048834006510 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1048834006511 Predicted helicase [General function prediction only]; Region: COG4889 1048834006512 Predicted helicase [General function prediction only]; Region: COG4889 1048834006513 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1048834006514 Restriction endonuclease; Region: Mrr_cat; pfam04471 1048834006515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048834006516 ATP binding site [chemical binding]; other site 1048834006517 putative Mg++ binding site [ion binding]; other site 1048834006518 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1048834006519 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1048834006520 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1048834006521 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1048834006522 active site 1048834006523 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1048834006524 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1048834006525 active site 1048834006526 NTP binding site [chemical binding]; other site 1048834006527 metal binding triad [ion binding]; metal-binding site 1048834006528 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1048834006529 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1048834006530 active site 1048834006531 metal binding site [ion binding]; metal-binding site 1048834006532 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1048834006533 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048834006534 DNA binding residues [nucleotide binding] 1048834006535 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1048834006536 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048834006537 DNA binding residues [nucleotide binding] 1048834006538 DNA polymerase IV; Reviewed; Region: PRK03103 1048834006539 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1048834006540 active site 1048834006541 DNA binding site [nucleotide binding] 1048834006542 YolD-like protein; Region: YolD; pfam08863 1048834006543 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 1048834006544 polypeptide substrate binding site [polypeptide binding]; other site 1048834006545 active site 1048834006546 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1048834006547 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048834006548 DNA binding residues [nucleotide binding] 1048834006549 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1048834006550 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1048834006551 P-loop; other site 1048834006552 Magnesium ion binding site [ion binding]; other site 1048834006553 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1048834006554 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048834006555 active site 1048834006556 exodeoxyribonuclease X; Provisional; Region: PRK07983 1048834006557 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1048834006558 active site 1048834006559 catalytic site [active] 1048834006560 substrate binding site [chemical binding]; other site 1048834006561 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 1048834006562 hypothetical protein; Provisional; Region: PRK06547 1048834006563 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 1048834006564 Protein of unknown function (DUF669); Region: DUF669; pfam05037 1048834006565 DNA polymerase III subunit beta; Validated; Region: PRK05643 1048834006566 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1048834006567 putative DNA binding surface [nucleotide binding]; other site 1048834006568 dimer interface [polypeptide binding]; other site 1048834006569 beta-clamp/translesion DNA polymerase binding surface; other site 1048834006570 beta-clamp/clamp loader binding surface; other site 1048834006571 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 1048834006572 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1048834006573 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1048834006574 DNA binding residues [nucleotide binding] 1048834006575 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1048834006576 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1048834006577 ATP binding site [chemical binding]; other site 1048834006578 putative Mg++ binding site [ion binding]; other site 1048834006579 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048834006580 nucleotide binding region [chemical binding]; other site 1048834006581 ATP-binding site [chemical binding]; other site 1048834006582 Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896 1048834006583 Phage associated DNA primase [General function prediction only]; Region: COG3378 1048834006584 Prophage antirepressor [Transcription]; Region: COG3617 1048834006585 BRO family, N-terminal domain; Region: Bro-N; smart01040 1048834006586 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1048834006587 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1048834006588 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1048834006589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834006590 sequence-specific DNA binding site [nucleotide binding]; other site 1048834006591 salt bridge; other site 1048834006592 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1048834006593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834006594 non-specific DNA binding site [nucleotide binding]; other site 1048834006595 salt bridge; other site 1048834006596 sequence-specific DNA binding site [nucleotide binding]; other site 1048834006597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834006598 non-specific DNA binding site [nucleotide binding]; other site 1048834006599 salt bridge; other site 1048834006600 sequence-specific DNA binding site [nucleotide binding]; other site 1048834006601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834006602 salt bridge; other site 1048834006603 non-specific DNA binding site [nucleotide binding]; other site 1048834006604 sequence-specific DNA binding site [nucleotide binding]; other site 1048834006605 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834006606 sequence-specific DNA binding site [nucleotide binding]; other site 1048834006607 salt bridge; other site 1048834006608 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1048834006609 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1048834006610 catalytic residues [active] 1048834006611 catalytic nucleophile [active] 1048834006612 Recombinase; Region: Recombinase; pfam07508 1048834006613 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1048834006614 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1048834006615 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048834006616 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1048834006617 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1048834006618 active site 1048834006619 lysine transporter; Provisional; Region: PRK10836 1048834006620 Stage II sporulation protein; Region: SpoIID; pfam08486 1048834006621 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1048834006622 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048834006623 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1048834006624 Walker A/P-loop; other site 1048834006625 ATP binding site [chemical binding]; other site 1048834006626 Q-loop/lid; other site 1048834006627 ABC transporter signature motif; other site 1048834006628 Walker B; other site 1048834006629 D-loop; other site 1048834006630 H-loop/switch region; other site 1048834006631 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1048834006632 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048834006633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834006634 Walker A/P-loop; other site 1048834006635 ATP binding site [chemical binding]; other site 1048834006636 Q-loop/lid; other site 1048834006637 ABC transporter signature motif; other site 1048834006638 Walker B; other site 1048834006639 D-loop; other site 1048834006640 H-loop/switch region; other site 1048834006641 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1048834006642 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1048834006643 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1048834006644 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 1048834006645 peptide binding site [polypeptide binding]; other site 1048834006646 dimer interface [polypeptide binding]; other site 1048834006647 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1048834006648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834006649 dimer interface [polypeptide binding]; other site 1048834006650 conserved gate region; other site 1048834006651 putative PBP binding loops; other site 1048834006652 ABC-ATPase subunit interface; other site 1048834006653 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1048834006654 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1048834006655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834006656 dimer interface [polypeptide binding]; other site 1048834006657 conserved gate region; other site 1048834006658 ABC-ATPase subunit interface; other site 1048834006659 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 1048834006660 peptide binding site [polypeptide binding]; other site 1048834006661 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1048834006662 dimer interface [polypeptide binding]; other site 1048834006663 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1048834006664 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048834006665 Walker A/P-loop; other site 1048834006666 ATP binding site [chemical binding]; other site 1048834006667 Q-loop/lid; other site 1048834006668 ABC transporter signature motif; other site 1048834006669 Walker B; other site 1048834006670 D-loop; other site 1048834006671 H-loop/switch region; other site 1048834006672 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1048834006673 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1048834006674 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048834006675 Walker A/P-loop; other site 1048834006676 ATP binding site [chemical binding]; other site 1048834006677 Q-loop/lid; other site 1048834006678 ABC transporter signature motif; other site 1048834006679 Walker B; other site 1048834006680 D-loop; other site 1048834006681 H-loop/switch region; other site 1048834006682 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1048834006683 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1048834006684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834006685 active site 1048834006686 phosphorylation site [posttranslational modification] 1048834006687 intermolecular recognition site; other site 1048834006688 dimerization interface [polypeptide binding]; other site 1048834006689 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048834006690 DNA binding site [nucleotide binding] 1048834006691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048834006692 dimer interface [polypeptide binding]; other site 1048834006693 phosphorylation site [posttranslational modification] 1048834006694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834006695 ATP binding site [chemical binding]; other site 1048834006696 Mg2+ binding site [ion binding]; other site 1048834006697 G-X-G motif; other site 1048834006698 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1048834006699 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1048834006700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048834006701 dimer interface [polypeptide binding]; other site 1048834006702 phosphorylation site [posttranslational modification] 1048834006703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834006704 ATP binding site [chemical binding]; other site 1048834006705 Mg2+ binding site [ion binding]; other site 1048834006706 G-X-G motif; other site 1048834006707 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1048834006708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834006709 active site 1048834006710 phosphorylation site [posttranslational modification] 1048834006711 intermolecular recognition site; other site 1048834006712 dimerization interface [polypeptide binding]; other site 1048834006713 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048834006714 DNA binding site [nucleotide binding] 1048834006715 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1048834006716 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048834006717 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1048834006718 dimerization interface [polypeptide binding]; other site 1048834006719 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1048834006720 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1048834006721 IMP binding site; other site 1048834006722 GDP-binding site [chemical binding]; other site 1048834006723 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1048834006724 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048834006725 dimerization interface [polypeptide binding]; other site 1048834006726 Histidine kinase; Region: His_kinase; pfam06580 1048834006727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834006728 ATP binding site [chemical binding]; other site 1048834006729 Mg2+ binding site [ion binding]; other site 1048834006730 G-X-G motif; other site 1048834006731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1048834006732 Integrase core domain; Region: rve; pfam00665 1048834006733 Response regulator receiver domain; Region: Response_reg; pfam00072 1048834006734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834006735 active site 1048834006736 phosphorylation site [posttranslational modification] 1048834006737 intermolecular recognition site; other site 1048834006738 dimerization interface [polypeptide binding]; other site 1048834006739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048834006740 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1048834006741 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048834006742 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1048834006743 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1048834006744 ligand binding site [chemical binding]; other site 1048834006745 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1048834006746 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1048834006747 TM-ABC transporter signature motif; other site 1048834006748 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1048834006749 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1048834006750 Walker A/P-loop; other site 1048834006751 ATP binding site [chemical binding]; other site 1048834006752 Q-loop/lid; other site 1048834006753 ABC transporter signature motif; other site 1048834006754 Walker B; other site 1048834006755 D-loop; other site 1048834006756 H-loop/switch region; other site 1048834006757 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1048834006758 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1048834006759 active site 1048834006760 putative catalytic site [active] 1048834006761 DNA binding site [nucleotide binding] 1048834006762 putative phosphate binding site [ion binding]; other site 1048834006763 metal binding site A [ion binding]; metal-binding site 1048834006764 AP binding site [nucleotide binding]; other site 1048834006765 metal binding site B [ion binding]; metal-binding site 1048834006766 potential frameshift: common BLAST hit: gi|258512236|ref|YP_003185670.1| peptidase S41 1048834006767 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1048834006768 Active site serine [active] 1048834006769 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1048834006770 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1048834006771 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1048834006772 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1048834006773 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1048834006774 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1048834006775 pantothenate kinase; Provisional; Region: PRK05439 1048834006776 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1048834006777 ATP-binding site [chemical binding]; other site 1048834006778 CoA-binding site [chemical binding]; other site 1048834006779 Mg2+-binding site [ion binding]; other site 1048834006780 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1048834006781 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048834006782 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1048834006783 Walker A/P-loop; other site 1048834006784 ATP binding site [chemical binding]; other site 1048834006785 Q-loop/lid; other site 1048834006786 ABC transporter signature motif; other site 1048834006787 Walker B; other site 1048834006788 D-loop; other site 1048834006789 H-loop/switch region; other site 1048834006790 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1048834006791 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1048834006792 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834006793 Walker A/P-loop; other site 1048834006794 ATP binding site [chemical binding]; other site 1048834006795 Q-loop/lid; other site 1048834006796 ABC transporter signature motif; other site 1048834006797 Walker B; other site 1048834006798 D-loop; other site 1048834006799 H-loop/switch region; other site 1048834006800 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1048834006801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048834006802 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1048834006803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048834006804 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1048834006805 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1048834006806 SelR domain; Region: SelR; pfam01641 1048834006807 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1048834006808 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1048834006809 putative active site [active] 1048834006810 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1048834006811 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1048834006812 active site 1048834006813 mannonate dehydratase; Region: uxuA; TIGR00695 1048834006814 mannonate dehydratase; Provisional; Region: PRK03906 1048834006815 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1048834006816 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1048834006817 active site 1048834006818 intersubunit interface [polypeptide binding]; other site 1048834006819 catalytic residue [active] 1048834006820 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1048834006821 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1048834006822 substrate binding site [chemical binding]; other site 1048834006823 ATP binding site [chemical binding]; other site 1048834006824 Glycerate kinase family; Region: Gly_kinase; cl00841 1048834006825 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1048834006826 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cl01317 1048834006827 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 1048834006828 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 1048834006829 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 1048834006830 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 1048834006831 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 1048834006832 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 1048834006833 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 1048834006834 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 1048834006835 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 1048834006836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834006837 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048834006838 putative substrate translocation pore; other site 1048834006839 LabA_like proteins; Region: LabA; cd10911 1048834006840 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1048834006841 putative metal binding site [ion binding]; other site 1048834006842 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1048834006843 ROK family; Region: ROK; pfam00480 1048834006844 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1048834006845 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048834006846 dimerization interface [polypeptide binding]; other site 1048834006847 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1048834006848 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1048834006849 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1048834006850 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1048834006851 catalytic triad [active] 1048834006852 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1048834006853 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1048834006854 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1048834006855 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1048834006856 Zn2+ binding site [ion binding]; other site 1048834006857 Mg2+ binding site [ion binding]; other site 1048834006858 polyphosphate kinase; Provisional; Region: PRK05443 1048834006859 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1048834006860 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1048834006861 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1048834006862 putative domain interface [polypeptide binding]; other site 1048834006863 putative active site [active] 1048834006864 catalytic site [active] 1048834006865 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1048834006866 putative domain interface [polypeptide binding]; other site 1048834006867 putative active site [active] 1048834006868 catalytic site [active] 1048834006869 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1048834006870 drug efflux system protein MdtG; Provisional; Region: PRK09874 1048834006871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834006872 putative substrate translocation pore; other site 1048834006873 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1048834006874 Coat F domain; Region: Coat_F; pfam07875 1048834006875 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1048834006876 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048834006877 DNA-binding site [nucleotide binding]; DNA binding site 1048834006878 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1048834006879 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1048834006880 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1048834006881 dimer interface [polypeptide binding]; other site 1048834006882 active site 1048834006883 galactokinase; Provisional; Region: PRK05322 1048834006884 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1048834006885 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1048834006886 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1048834006887 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048834006888 Coenzyme A binding pocket [chemical binding]; other site 1048834006889 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1048834006890 VIT family; Region: VIT1; pfam01988 1048834006891 L-idonate 5-dehydrogenase; Region: PLN02702 1048834006892 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1048834006893 inhibitor binding site; inhibition site 1048834006894 catalytic Zn binding site [ion binding]; other site 1048834006895 structural Zn binding site [ion binding]; other site 1048834006896 NADP binding site [chemical binding]; other site 1048834006897 tetramer interface [polypeptide binding]; other site 1048834006898 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1048834006899 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1048834006900 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1048834006901 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1048834006902 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1048834006903 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1048834006904 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1048834006905 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1048834006906 DXD motif; other site 1048834006907 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 1048834006908 active site 1048834006909 dimer interface [polypeptide binding]; other site 1048834006910 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1048834006911 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1048834006912 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1048834006913 HTH domain; Region: HTH_11; pfam08279 1048834006914 3H domain; Region: 3H; pfam02829 1048834006915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834006916 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048834006917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834006918 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1048834006919 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1048834006920 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1048834006921 catalytic residue [active] 1048834006922 dephospho-CoA kinase; Region: TIGR00152 1048834006923 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1048834006924 CoA-binding site [chemical binding]; other site 1048834006925 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1048834006926 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1048834006927 DNA binding site [nucleotide binding] 1048834006928 catalytic residue [active] 1048834006929 H2TH interface [polypeptide binding]; other site 1048834006930 putative catalytic residues [active] 1048834006931 turnover-facilitating residue; other site 1048834006932 intercalation triad [nucleotide binding]; other site 1048834006933 8OG recognition residue [nucleotide binding]; other site 1048834006934 putative reading head residues; other site 1048834006935 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1048834006936 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1048834006937 DNA polymerase I; Provisional; Region: PRK05755 1048834006938 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1048834006939 active site 1048834006940 metal binding site 1 [ion binding]; metal-binding site 1048834006941 putative 5' ssDNA interaction site; other site 1048834006942 metal binding site 3; metal-binding site 1048834006943 metal binding site 2 [ion binding]; metal-binding site 1048834006944 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1048834006945 putative DNA binding site [nucleotide binding]; other site 1048834006946 putative metal binding site [ion binding]; other site 1048834006947 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1048834006948 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1048834006949 active site 1048834006950 DNA binding site [nucleotide binding] 1048834006951 catalytic site [active] 1048834006952 Chorismate mutase type II; Region: CM_2; smart00830 1048834006953 malate dehydrogenase; Reviewed; Region: PRK06223 1048834006954 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1048834006955 NAD(P) binding site [chemical binding]; other site 1048834006956 dimer interface [polypeptide binding]; other site 1048834006957 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1048834006958 substrate binding site [chemical binding]; other site 1048834006959 isocitrate dehydrogenase; Validated; Region: PRK07362 1048834006960 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1048834006961 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1048834006962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048834006963 dimer interface [polypeptide binding]; other site 1048834006964 phosphorylation site [posttranslational modification] 1048834006965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834006966 ATP binding site [chemical binding]; other site 1048834006967 Mg2+ binding site [ion binding]; other site 1048834006968 G-X-G motif; other site 1048834006969 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1048834006970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834006971 active site 1048834006972 phosphorylation site [posttranslational modification] 1048834006973 intermolecular recognition site; other site 1048834006974 dimerization interface [polypeptide binding]; other site 1048834006975 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048834006976 DNA binding site [nucleotide binding] 1048834006977 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1048834006978 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1048834006979 active site 1048834006980 HIGH motif; other site 1048834006981 dimer interface [polypeptide binding]; other site 1048834006982 KMSKS motif; other site 1048834006983 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1048834006984 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1048834006985 domain interfaces; other site 1048834006986 active site 1048834006987 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1048834006988 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1048834006989 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1048834006990 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1048834006991 4-aminobutyrate transaminase; Provisional; Region: PRK09792 1048834006992 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1048834006993 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1048834006994 active site 1048834006995 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1048834006996 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1048834006997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048834006998 DNA-binding site [nucleotide binding]; DNA binding site 1048834006999 DRTGG domain; Region: DRTGG; pfam07085 1048834007000 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1048834007001 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1048834007002 active site 2 [active] 1048834007003 active site 1 [active] 1048834007004 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1048834007005 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1048834007006 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1048834007007 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1048834007008 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1048834007009 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1048834007010 dimer interface [polypeptide binding]; other site 1048834007011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834007012 catalytic residue [active] 1048834007013 arginine repressor; Provisional; Region: PRK04280 1048834007014 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1048834007015 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1048834007016 DNA polymerase IV; Validated; Region: PRK01810 1048834007017 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1048834007018 active site 1048834007019 DNA binding site [nucleotide binding] 1048834007020 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1048834007021 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1048834007022 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1048834007023 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1048834007024 Protein of unknown function (DUF964); Region: DUF964; cl01483 1048834007025 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1048834007026 apolar tunnel; other site 1048834007027 heme binding site [chemical binding]; other site 1048834007028 dimerization interface [polypeptide binding]; other site 1048834007029 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1048834007030 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834007031 non-specific DNA binding site [nucleotide binding]; other site 1048834007032 salt bridge; other site 1048834007033 sequence-specific DNA binding site [nucleotide binding]; other site 1048834007034 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1048834007035 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1048834007036 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1048834007037 active site 1048834007038 HIGH motif; other site 1048834007039 nucleotide binding site [chemical binding]; other site 1048834007040 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1048834007041 active site 1048834007042 KMSKS motif; other site 1048834007043 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1048834007044 tRNA binding surface [nucleotide binding]; other site 1048834007045 anticodon binding site; other site 1048834007046 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1048834007047 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1048834007048 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1048834007049 serine O-acetyltransferase; Region: cysE; TIGR01172 1048834007050 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1048834007051 trimer interface [polypeptide binding]; other site 1048834007052 active site 1048834007053 substrate binding site [chemical binding]; other site 1048834007054 CoA binding site [chemical binding]; other site 1048834007055 hypothetical protein; Provisional; Region: PRK08201 1048834007056 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 1048834007057 metal binding site [ion binding]; metal-binding site 1048834007058 putative dimer interface [polypeptide binding]; other site 1048834007059 transcriptional repressor CodY; Validated; Region: PRK04158 1048834007060 CodY GAF-like domain; Region: CodY; pfam06018 1048834007061 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1048834007062 Trp repressor protein; Region: Trp_repressor; cl17266 1048834007063 Sulfocyanin (SoxE); Region: SoxE; cl17563 1048834007064 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1048834007065 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1048834007066 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1048834007067 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1048834007068 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1048834007069 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1048834007070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834007071 non-specific DNA binding site [nucleotide binding]; other site 1048834007072 salt bridge; other site 1048834007073 sequence-specific DNA binding site [nucleotide binding]; other site 1048834007074 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1048834007075 Coenzyme A binding pocket [chemical binding]; other site 1048834007076 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1048834007077 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1048834007078 sequence-specific DNA binding site [nucleotide binding]; other site 1048834007079 salt bridge; other site 1048834007080 Domain of unknown function DUF87; Region: DUF87; pfam01935 1048834007081 AAA-like domain; Region: AAA_10; pfam12846 1048834007082 NurA domain; Region: NurA; cl09134 1048834007083 DNA methylase; Region: N6_N4_Mtase; cl17433 1048834007084 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1048834007085 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 1048834007086 dimer interface [polypeptide binding]; other site 1048834007087 motif 1; other site 1048834007088 active site 1048834007089 motif 2; other site 1048834007090 motif 3; other site 1048834007091 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 1048834007092 anticodon binding site; other site 1048834007093 zinc-binding site [ion binding]; other site 1048834007094 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1048834007095 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1048834007096 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 1048834007097 putative NAD(P) binding site [chemical binding]; other site 1048834007098 catalytic Zn binding site [ion binding]; other site 1048834007099 structural Zn binding site [ion binding]; other site 1048834007100 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1048834007101 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1048834007102 active site 1048834007103 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1048834007104 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1048834007105 acyl-activating enzyme (AAE) consensus motif; other site 1048834007106 AMP binding site [chemical binding]; other site 1048834007107 active site 1048834007108 CoA binding site [chemical binding]; other site 1048834007109 acyl carrier protein; Provisional; Region: acpP; PRK00982 1048834007110 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1048834007111 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1048834007112 putative NAD(P) binding site [chemical binding]; other site 1048834007113 active site 1048834007114 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1048834007115 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1048834007116 active site 1048834007117 FMN binding site [chemical binding]; other site 1048834007118 2,4-decadienoyl-CoA binding site; other site 1048834007119 catalytic residue [active] 1048834007120 4Fe-4S cluster binding site [ion binding]; other site 1048834007121 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 1048834007122 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1048834007123 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1048834007124 acyl-activating enzyme (AAE) consensus motif; other site 1048834007125 putative AMP binding site [chemical binding]; other site 1048834007126 putative active site [active] 1048834007127 putative CoA binding site [chemical binding]; other site 1048834007128 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1048834007129 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1048834007130 active site 1048834007131 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 1048834007132 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1048834007133 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1048834007134 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1048834007135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1048834007136 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1048834007137 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1048834007138 TrkA-C domain; Region: TrkA_C; pfam02080 1048834007139 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1048834007140 classical (c) SDRs; Region: SDR_c; cd05233 1048834007141 NAD(P) binding site [chemical binding]; other site 1048834007142 active site 1048834007143 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1048834007144 active site 1048834007145 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1048834007146 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1048834007147 putative NAD(P) binding site [chemical binding]; other site 1048834007148 active site 1048834007149 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1048834007150 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1048834007151 dimer interface [polypeptide binding]; other site 1048834007152 active site 1048834007153 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1048834007154 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048834007155 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048834007156 active site 1048834007157 catalytic tetrad [active] 1048834007158 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1048834007159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048834007160 motif II; other site 1048834007161 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048834007162 dimerization interface [polypeptide binding]; other site 1048834007163 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1048834007164 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1048834007165 dimer interface [polypeptide binding]; other site 1048834007166 putative CheW interface [polypeptide binding]; other site 1048834007167 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1048834007168 CoenzymeA binding site [chemical binding]; other site 1048834007169 subunit interaction site [polypeptide binding]; other site 1048834007170 PHB binding site; other site 1048834007171 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1048834007172 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1048834007173 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1048834007174 putative active site [active] 1048834007175 putative substrate binding site [chemical binding]; other site 1048834007176 putative cosubstrate binding site; other site 1048834007177 catalytic site [active] 1048834007178 Sm and related proteins; Region: Sm_like; cl00259 1048834007179 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1048834007180 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1048834007181 putative active site [active] 1048834007182 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1048834007183 putative active site [active] 1048834007184 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1048834007185 active site 1048834007186 SAM binding site [chemical binding]; other site 1048834007187 homodimer interface [polypeptide binding]; other site 1048834007188 sulfite reductase subunit beta; Provisional; Region: PRK13504 1048834007189 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1048834007190 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1048834007191 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1048834007192 Active Sites [active] 1048834007193 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1048834007194 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1048834007195 Predicted integral membrane protein [Function unknown]; Region: COG5542 1048834007196 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1048834007197 Ligand binding site; other site 1048834007198 Putative Catalytic site; other site 1048834007199 DXD motif; other site 1048834007200 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1048834007201 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1048834007202 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1048834007203 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1048834007204 active site 1048834007205 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1048834007206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834007207 putative substrate translocation pore; other site 1048834007208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834007209 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1048834007210 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048834007211 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1048834007212 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1048834007213 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1048834007214 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 1048834007215 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1048834007216 DXD motif; other site 1048834007217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1048834007218 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1048834007219 NlpC/P60 family; Region: NLPC_P60; pfam00877 1048834007220 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 1048834007221 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1048834007222 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1048834007223 putative metal binding site [ion binding]; other site 1048834007224 Spore germination protein; Region: Spore_permease; cl17796 1048834007225 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1048834007226 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1048834007227 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1048834007228 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1048834007229 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1048834007230 protein binding site [polypeptide binding]; other site 1048834007231 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1048834007232 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1048834007233 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1048834007234 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1048834007235 active site lid residues [active] 1048834007236 substrate binding pocket [chemical binding]; other site 1048834007237 catalytic residues [active] 1048834007238 substrate-Mg2+ binding site; other site 1048834007239 aspartate-rich region 1; other site 1048834007240 aspartate-rich region 2; other site 1048834007241 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1048834007242 active site lid residues [active] 1048834007243 substrate binding pocket [chemical binding]; other site 1048834007244 catalytic residues [active] 1048834007245 substrate-Mg2+ binding site; other site 1048834007246 aspartate-rich region 1; other site 1048834007247 aspartate-rich region 2; other site 1048834007248 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1048834007249 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1048834007250 Active site cavity [active] 1048834007251 catalytic acid [active] 1048834007252 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1048834007253 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1048834007254 putative NADP binding site [chemical binding]; other site 1048834007255 putative substrate binding site [chemical binding]; other site 1048834007256 active site 1048834007257 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1048834007258 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 1048834007259 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048834007260 FeS/SAM binding site; other site 1048834007261 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 1048834007262 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1048834007263 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1048834007264 homotetramer interface [polypeptide binding]; other site 1048834007265 FMN binding site [chemical binding]; other site 1048834007266 homodimer contacts [polypeptide binding]; other site 1048834007267 putative active site [active] 1048834007268 putative substrate binding site [chemical binding]; other site 1048834007269 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1048834007270 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1048834007271 TPP-binding site; other site 1048834007272 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1048834007273 PYR/PP interface [polypeptide binding]; other site 1048834007274 dimer interface [polypeptide binding]; other site 1048834007275 TPP binding site [chemical binding]; other site 1048834007276 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1048834007277 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 1048834007278 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 1048834007279 polypeptide substrate binding site [polypeptide binding]; other site 1048834007280 active site 1048834007281 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1048834007282 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1048834007283 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1048834007284 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1048834007285 acyl-activating enzyme (AAE) consensus motif; other site 1048834007286 AMP binding site [chemical binding]; other site 1048834007287 active site 1048834007288 CoA binding site [chemical binding]; other site 1048834007289 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 1048834007290 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 1048834007291 active site 1048834007292 Zn binding site [ion binding]; other site 1048834007293 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1048834007294 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1048834007295 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1048834007296 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1048834007297 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1048834007298 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1048834007299 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1048834007300 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 1048834007301 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1048834007302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834007303 dimer interface [polypeptide binding]; other site 1048834007304 conserved gate region; other site 1048834007305 putative PBP binding loops; other site 1048834007306 ABC-ATPase subunit interface; other site 1048834007307 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1048834007308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834007309 dimer interface [polypeptide binding]; other site 1048834007310 putative PBP binding loops; other site 1048834007311 ABC-ATPase subunit interface; other site 1048834007312 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1048834007313 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1048834007314 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1048834007315 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1048834007316 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1048834007317 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1048834007318 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1048834007319 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048834007320 DNA binding site [nucleotide binding] 1048834007321 domain linker motif; other site 1048834007322 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1048834007323 ligand binding site [chemical binding]; other site 1048834007324 dimerization interface [polypeptide binding]; other site 1048834007325 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1048834007326 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1048834007327 active site 1048834007328 catalytic site [active] 1048834007329 substrate binding site [chemical binding]; other site 1048834007330 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1048834007331 metal binding triad; other site 1048834007332 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 1048834007333 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1048834007334 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1048834007335 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1048834007336 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1048834007337 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1048834007338 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1048834007339 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1048834007340 motif II; other site 1048834007341 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1048834007342 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048834007343 Walker A/P-loop; other site 1048834007344 ATP binding site [chemical binding]; other site 1048834007345 Q-loop/lid; other site 1048834007346 ABC transporter signature motif; other site 1048834007347 Walker B; other site 1048834007348 D-loop; other site 1048834007349 H-loop/switch region; other site 1048834007350 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1048834007351 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1048834007352 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1048834007353 Walker A/P-loop; other site 1048834007354 ATP binding site [chemical binding]; other site 1048834007355 Q-loop/lid; other site 1048834007356 ABC transporter signature motif; other site 1048834007357 Walker B; other site 1048834007358 D-loop; other site 1048834007359 H-loop/switch region; other site 1048834007360 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1048834007361 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1048834007362 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1048834007363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834007364 dimer interface [polypeptide binding]; other site 1048834007365 conserved gate region; other site 1048834007366 putative PBP binding loops; other site 1048834007367 ABC-ATPase subunit interface; other site 1048834007368 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1048834007369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834007370 dimer interface [polypeptide binding]; other site 1048834007371 conserved gate region; other site 1048834007372 putative PBP binding loops; other site 1048834007373 ABC-ATPase subunit interface; other site 1048834007374 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1048834007375 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1048834007376 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1048834007377 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 1048834007378 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 1048834007379 quinolinate synthetase; Provisional; Region: PRK09375 1048834007380 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1048834007381 L-aspartate oxidase; Provisional; Region: PRK06175 1048834007382 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1048834007383 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1048834007384 active site 1048834007385 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048834007386 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1048834007387 FeS/SAM binding site; other site 1048834007388 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1048834007389 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1048834007390 ATP binding site [chemical binding]; other site 1048834007391 substrate interface [chemical binding]; other site 1048834007392 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1048834007393 ThiS interaction site; other site 1048834007394 putative active site [active] 1048834007395 tetramer interface [polypeptide binding]; other site 1048834007396 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1048834007397 thiS-thiF/thiG interaction site; other site 1048834007398 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1048834007399 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1048834007400 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1048834007401 active site 1048834007402 thiamine phosphate binding site [chemical binding]; other site 1048834007403 pyrophosphate binding site [ion binding]; other site 1048834007404 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1048834007405 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1048834007406 DHHA2 domain; Region: DHHA2; pfam02833 1048834007407 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048834007408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834007409 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1048834007410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834007411 putative substrate translocation pore; other site 1048834007412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834007413 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1048834007414 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1048834007415 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1048834007416 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1048834007417 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 1048834007418 peptide binding site [polypeptide binding]; other site 1048834007419 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1048834007420 dimer interface [polypeptide binding]; other site 1048834007421 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 1048834007422 peptide binding site [polypeptide binding]; other site 1048834007423 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1048834007424 dimer interface [polypeptide binding]; other site 1048834007425 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 1048834007426 DinB superfamily; Region: DinB_2; pfam12867 1048834007427 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1048834007428 TIGR01777 family protein; Region: yfcH 1048834007429 putative NAD(P) binding site [chemical binding]; other site 1048834007430 putative active site [active] 1048834007431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834007432 D-galactonate transporter; Region: 2A0114; TIGR00893 1048834007433 putative substrate translocation pore; other site 1048834007434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834007435 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1048834007436 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1048834007437 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834007438 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1048834007439 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1048834007440 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1048834007441 active site 1048834007442 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1048834007443 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1048834007444 conserved cys residue [active] 1048834007445 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1048834007446 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1048834007447 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1048834007448 dimer interface [polypeptide binding]; other site 1048834007449 putative CheW interface [polypeptide binding]; other site 1048834007450 amino acid transporter; Region: 2A0306; TIGR00909 1048834007451 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1048834007452 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1048834007453 NAD(P) binding site [chemical binding]; other site 1048834007454 catalytic residues [active] 1048834007455 BclB C-terminal domain; Region: exospore_TM; TIGR03721 1048834007456 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1048834007457 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1048834007458 putative metal binding site; other site 1048834007459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1048834007460 binding surface 1048834007461 TPR motif; other site 1048834007462 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 1048834007463 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1048834007464 substrate binding site [chemical binding]; other site 1048834007465 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1048834007466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048834007467 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1048834007468 putative dimerization interface [polypeptide binding]; other site 1048834007469 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1048834007470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834007471 D-galactonate transporter; Region: 2A0114; TIGR00893 1048834007472 putative substrate translocation pore; other site 1048834007473 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1048834007474 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1048834007475 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1048834007476 NAD(P) binding site [chemical binding]; other site 1048834007477 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1048834007478 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1048834007479 catalytic residue [active] 1048834007480 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1048834007481 catalytic residues [active] 1048834007482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1048834007483 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1048834007484 peroxiredoxin; Region: AhpC; TIGR03137 1048834007485 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1048834007486 dimer interface [polypeptide binding]; other site 1048834007487 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1048834007488 catalytic triad [active] 1048834007489 peroxidatic and resolving cysteines [active] 1048834007490 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1048834007491 metal binding site 2 [ion binding]; metal-binding site 1048834007492 putative DNA binding helix; other site 1048834007493 metal binding site 1 [ion binding]; metal-binding site 1048834007494 dimer interface [polypeptide binding]; other site 1048834007495 structural Zn2+ binding site [ion binding]; other site 1048834007496 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1048834007497 acyl-CoA synthetase; Validated; Region: PRK08162 1048834007498 acyl-activating enzyme (AAE) consensus motif; other site 1048834007499 putative active site [active] 1048834007500 AMP binding site [chemical binding]; other site 1048834007501 putative CoA binding site [chemical binding]; other site 1048834007502 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 1048834007503 Proline dehydrogenase; Region: Pro_dh; cl03282 1048834007504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048834007505 PAS domain; Region: PAS_9; pfam13426 1048834007506 putative active site [active] 1048834007507 heme pocket [chemical binding]; other site 1048834007508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834007509 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1048834007510 Walker A motif; other site 1048834007511 ATP binding site [chemical binding]; other site 1048834007512 Walker B motif; other site 1048834007513 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1048834007514 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1048834007515 FAD binding domain; Region: FAD_binding_4; pfam01565 1048834007516 putative sialic acid transporter; Region: 2A0112; TIGR00891 1048834007517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834007518 putative substrate translocation pore; other site 1048834007519 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1048834007520 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1048834007521 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1048834007522 L-lactate permease; Region: Lactate_perm; cl00701 1048834007523 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1048834007524 malate synthase A; Region: malate_syn_A; TIGR01344 1048834007525 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1048834007526 active site 1048834007527 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1048834007528 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1048834007529 Bacterial transcriptional regulator; Region: IclR; pfam01614 1048834007530 FAD binding domain; Region: FAD_binding_4; pfam01565 1048834007531 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1048834007532 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1048834007533 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1048834007534 Cysteine-rich domain; Region: CCG; pfam02754 1048834007535 Cysteine-rich domain; Region: CCG; pfam02754 1048834007536 FAD binding domain; Region: FAD_binding_4; pfam01565 1048834007537 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1048834007538 N-glycosyltransferase; Provisional; Region: PRK11204 1048834007539 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1048834007540 DXD motif; other site 1048834007541 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1048834007542 PgaD-like protein; Region: PgaD; cl14676 1048834007543 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1048834007544 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 1048834007545 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 1048834007546 catalytic residues [active] 1048834007547 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1048834007548 putative hydrophobic ligand binding site [chemical binding]; other site 1048834007549 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1048834007550 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1048834007551 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1048834007552 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1048834007553 peptide chain release factor 2; Provisional; Region: PRK05589 1048834007554 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1048834007555 RF-1 domain; Region: RF-1; pfam00472 1048834007556 CemA family; Region: CemA; cl03855 1048834007557 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1048834007558 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1048834007559 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1048834007560 nucleotide binding region [chemical binding]; other site 1048834007561 ATP-binding site [chemical binding]; other site 1048834007562 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1048834007563 30S subunit binding site; other site 1048834007564 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 1048834007565 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1048834007566 putative ADP-binding pocket [chemical binding]; other site 1048834007567 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1048834007568 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1048834007569 putative ADP-binding pocket [chemical binding]; other site 1048834007570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834007571 S-adenosylmethionine binding site [chemical binding]; other site 1048834007572 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1048834007573 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1048834007574 putative metal binding site; other site 1048834007575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1048834007576 binding surface 1048834007577 TPR motif; other site 1048834007578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1048834007579 binding surface 1048834007580 TPR motif; other site 1048834007581 Flagellar protein FliS; Region: FliS; cl00654 1048834007582 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1048834007583 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1048834007584 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1048834007585 flagellin; Provisional; Region: PRK12802 1048834007586 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1048834007587 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1048834007588 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1048834007589 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1048834007590 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1048834007591 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 1048834007592 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1048834007593 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1048834007594 flagellar operon protein TIGR03826; Region: YvyF 1048834007595 comF family protein; Region: comF; TIGR00201 1048834007596 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048834007597 active site 1048834007598 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1048834007599 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1048834007600 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048834007601 putative active site [active] 1048834007602 heme pocket [chemical binding]; other site 1048834007603 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048834007604 dimer interface [polypeptide binding]; other site 1048834007605 phosphorylation site [posttranslational modification] 1048834007606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834007607 ATP binding site [chemical binding]; other site 1048834007608 Mg2+ binding site [ion binding]; other site 1048834007609 G-X-G motif; other site 1048834007610 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1048834007611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834007612 active site 1048834007613 phosphorylation site [posttranslational modification] 1048834007614 intermolecular recognition site; other site 1048834007615 dimerization interface [polypeptide binding]; other site 1048834007616 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048834007617 DNA binding site [nucleotide binding] 1048834007618 Helix-turn-helix domain; Region: HTH_19; pfam12844 1048834007619 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1048834007620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834007621 active site 1048834007622 phosphorylation site [posttranslational modification] 1048834007623 intermolecular recognition site; other site 1048834007624 dimerization interface [polypeptide binding]; other site 1048834007625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1048834007626 DNA binding residues [nucleotide binding] 1048834007627 dimerization interface [polypeptide binding]; other site 1048834007628 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1048834007629 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1048834007630 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1048834007631 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1048834007632 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1048834007633 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1048834007634 drug efflux system protein MdtG; Provisional; Region: PRK09874 1048834007635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834007636 putative substrate translocation pore; other site 1048834007637 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1048834007638 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1048834007639 active site 1048834007640 substrate binding site [chemical binding]; other site 1048834007641 metal binding site [ion binding]; metal-binding site 1048834007642 Dienelactone hydrolase family; Region: DLH; pfam01738 1048834007643 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1048834007644 MPT binding site; other site 1048834007645 trimer interface [polypeptide binding]; other site 1048834007646 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1048834007647 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1048834007648 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1048834007649 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1048834007650 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1048834007651 ABC1 family; Region: ABC1; cl17513 1048834007652 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1048834007653 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1048834007654 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1048834007655 RNA binding surface [nucleotide binding]; other site 1048834007656 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1048834007657 active site 1048834007658 uracil binding [chemical binding]; other site 1048834007659 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1048834007660 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1048834007661 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1048834007662 ApbE family; Region: ApbE; pfam02424 1048834007663 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 1048834007664 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1048834007665 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048834007666 DNA binding site [nucleotide binding] 1048834007667 domain linker motif; other site 1048834007668 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1048834007669 ligand binding site [chemical binding]; other site 1048834007670 dimerization interface [polypeptide binding]; other site 1048834007671 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1048834007672 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1048834007673 active site 1048834007674 catalytic tetrad [active] 1048834007675 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1048834007676 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1048834007677 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1048834007678 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1048834007679 catalytic residues [active] 1048834007680 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 1048834007681 active site 1048834007682 catalytic triad [active] 1048834007683 oxyanion hole [active] 1048834007684 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1048834007685 ApbE family; Region: ApbE; pfam02424 1048834007686 FMN-binding domain; Region: FMN_bind; cl01081 1048834007687 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 1048834007688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834007689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048834007690 putative substrate translocation pore; other site 1048834007691 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1048834007692 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1048834007693 active site 1048834007694 ATP-binding site [chemical binding]; other site 1048834007695 pantoate-binding site; other site 1048834007696 HXXH motif; other site 1048834007697 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1048834007698 oligomerization interface [polypeptide binding]; other site 1048834007699 active site 1048834007700 metal binding site [ion binding]; metal-binding site 1048834007701 Rossmann-like domain; Region: Rossmann-like; pfam10727 1048834007702 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1048834007703 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1048834007704 metal binding site 2 [ion binding]; metal-binding site 1048834007705 putative DNA binding helix; other site 1048834007706 metal binding site 1 [ion binding]; metal-binding site 1048834007707 dimer interface [polypeptide binding]; other site 1048834007708 structural Zn2+ binding site [ion binding]; other site 1048834007709 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1048834007710 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1048834007711 intersubunit interface [polypeptide binding]; other site 1048834007712 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1048834007713 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1048834007714 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1048834007715 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1048834007716 ABC-ATPase subunit interface; other site 1048834007717 dimer interface [polypeptide binding]; other site 1048834007718 putative PBP binding regions; other site 1048834007719 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1048834007720 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1048834007721 putative PBP binding regions; other site 1048834007722 ABC-ATPase subunit interface; other site 1048834007723 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1048834007724 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1048834007725 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1048834007726 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1048834007727 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1048834007728 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1048834007729 structural tetrad; other site 1048834007730 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1048834007731 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1048834007732 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1048834007733 PAS domain; Region: PAS_9; pfam13426 1048834007734 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048834007735 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048834007736 metal binding site [ion binding]; metal-binding site 1048834007737 active site 1048834007738 I-site; other site 1048834007739 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048834007740 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1048834007741 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1048834007742 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1048834007743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834007744 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048834007745 putative substrate translocation pore; other site 1048834007746 CopC domain; Region: CopC; pfam04234 1048834007747 Copper resistance protein D; Region: CopD; cl00563 1048834007748 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1048834007749 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1048834007750 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1048834007751 MarR family; Region: MarR_2; pfam12802 1048834007752 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1048834007753 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1048834007754 nucleotide binding site [chemical binding]; other site 1048834007755 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1048834007756 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1048834007757 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1048834007758 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1048834007759 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1048834007760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834007761 dimer interface [polypeptide binding]; other site 1048834007762 conserved gate region; other site 1048834007763 putative PBP binding loops; other site 1048834007764 ABC-ATPase subunit interface; other site 1048834007765 potential frameshift: common BLAST hit: gi|379007835|ref|YP_005257286.1| ABC transporter 1048834007766 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1048834007767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834007768 dimer interface [polypeptide binding]; other site 1048834007769 conserved gate region; other site 1048834007770 ABC-ATPase subunit interface; other site 1048834007771 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1048834007772 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1048834007773 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1048834007774 active site 1048834007775 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1048834007776 Putative zinc-finger; Region: zf-HC2; pfam13490 1048834007777 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1048834007778 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048834007779 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1048834007780 DNA binding residues [nucleotide binding] 1048834007781 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 1048834007782 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1048834007783 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1048834007784 active site 2 [active] 1048834007785 active site 1 [active] 1048834007786 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1048834007787 active site 2 [active] 1048834007788 active site 1 [active] 1048834007789 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1048834007790 putative homodimer interface [polypeptide binding]; other site 1048834007791 putative homotetramer interface [polypeptide binding]; other site 1048834007792 putative metal binding site [ion binding]; other site 1048834007793 putative homodimer-homodimer interface [polypeptide binding]; other site 1048834007794 putative allosteric switch controlling residues; other site 1048834007795 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1048834007796 Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712 1048834007797 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1048834007798 active site residue [active] 1048834007799 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1048834007800 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1048834007801 CPxP motif; other site 1048834007802 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1048834007803 active site residue [active] 1048834007804 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 1048834007805 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1048834007806 active site residue [active] 1048834007807 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1048834007808 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 1048834007809 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 1048834007810 CRISPR-associated protein Csx17, subtype Dpsyc; Region: cas_csx17; TIGR04113 1048834007811 CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767 1048834007812 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1048834007813 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1048834007814 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1048834007815 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 1048834007816 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1048834007817 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1048834007818 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1048834007819 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1048834007820 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1048834007821 DNA binding residues [nucleotide binding] 1048834007822 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1048834007823 catalytic residues [active] 1048834007824 catalytic nucleophile [active] 1048834007825 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1048834007826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1048834007827 Probable transposase; Region: OrfB_IS605; pfam01385 1048834007828 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1048834007829 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1048834007830 ThiC-associated domain; Region: ThiC-associated; pfam13667 1048834007831 ThiC family; Region: ThiC; pfam01964 1048834007832 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1048834007833 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1048834007834 Na binding site [ion binding]; other site 1048834007835 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 1048834007836 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1048834007837 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1048834007838 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1048834007839 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1048834007840 metal-binding site [ion binding] 1048834007841 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1048834007842 putative homodimer interface [polypeptide binding]; other site 1048834007843 putative homotetramer interface [polypeptide binding]; other site 1048834007844 putative allosteric switch controlling residues; other site 1048834007845 putative metal binding site [ion binding]; other site 1048834007846 putative homodimer-homodimer interface [polypeptide binding]; other site 1048834007847 Asp23 family; Region: Asp23; pfam03780 1048834007848 Asp23 family; Region: Asp23; pfam03780 1048834007849 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1048834007850 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1048834007851 AsnC family; Region: AsnC_trans_reg; pfam01037 1048834007852 hypothetical protein; Validated; Region: PRK07682 1048834007853 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048834007854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834007855 homodimer interface [polypeptide binding]; other site 1048834007856 catalytic residue [active] 1048834007857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834007858 putative substrate translocation pore; other site 1048834007859 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048834007860 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1048834007861 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1048834007862 putative NAD(P) binding site [chemical binding]; other site 1048834007863 putative substrate binding site [chemical binding]; other site 1048834007864 catalytic Zn binding site [ion binding]; other site 1048834007865 structural Zn binding site [ion binding]; other site 1048834007866 dimer interface [polypeptide binding]; other site 1048834007867 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1048834007868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1048834007869 aminotransferase; Validated; Region: PRK07678 1048834007870 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1048834007871 inhibitor-cofactor binding pocket; inhibition site 1048834007872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834007873 catalytic residue [active] 1048834007874 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1048834007875 active site 1048834007876 catalytic triad [active] 1048834007877 dimer interface [polypeptide binding]; other site 1048834007878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834007879 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1048834007880 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1048834007881 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1048834007882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834007883 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1048834007884 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1048834007885 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1048834007886 homodimer interface [polypeptide binding]; other site 1048834007887 active site 1048834007888 FMN binding site [chemical binding]; other site 1048834007889 substrate binding site [chemical binding]; other site 1048834007890 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1048834007891 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1048834007892 Helix-turn-helix domains; Region: HTH; cl00088 1048834007893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834007894 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1048834007895 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1048834007896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834007897 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1048834007898 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1048834007899 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1048834007900 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1048834007901 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1048834007902 MULE transposase domain; Region: MULE; pfam10551 1048834007903 H+ Antiporter protein; Region: 2A0121; TIGR00900 1048834007904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834007905 putative substrate translocation pore; other site 1048834007906 Helix-turn-helix domains; Region: HTH; cl00088 1048834007907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834007908 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1048834007909 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1048834007910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1048834007911 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1048834007912 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1048834007913 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1048834007914 MULE transposase domain; Region: MULE; pfam10551 1048834007915 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834007916 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1048834007917 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1048834007918 glutaminase active site [active] 1048834007919 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1048834007920 dimer interface [polypeptide binding]; other site 1048834007921 active site 1048834007922 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1048834007923 dimer interface [polypeptide binding]; other site 1048834007924 active site 1048834007925 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1048834007926 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1048834007927 active site 1048834007928 substrate binding site [chemical binding]; other site 1048834007929 metal binding site [ion binding]; metal-binding site 1048834007930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1048834007931 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1048834007932 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1048834007933 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1048834007934 active site 1048834007935 catalytic triad [active] 1048834007936 oxyanion hole [active] 1048834007937 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1048834007938 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 1048834007939 NodB motif; other site 1048834007940 putative active site [active] 1048834007941 putative catalytic site [active] 1048834007942 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1048834007943 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1048834007944 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1048834007945 Walker A motif; other site 1048834007946 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1048834007947 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1048834007948 active site 1048834007949 metal binding site [ion binding]; metal-binding site 1048834007950 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1048834007951 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1048834007952 23S rRNA interface [nucleotide binding]; other site 1048834007953 L3 interface [polypeptide binding]; other site 1048834007954 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1048834007955 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1048834007956 active site 1048834007957 dimerization interface 3.5A [polypeptide binding]; other site 1048834007958 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1048834007959 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1048834007960 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1048834007961 alphaNTD homodimer interface [polypeptide binding]; other site 1048834007962 alphaNTD - beta interaction site [polypeptide binding]; other site 1048834007963 alphaNTD - beta' interaction site [polypeptide binding]; other site 1048834007964 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1048834007965 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1048834007966 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1048834007967 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1048834007968 RNA binding surface [nucleotide binding]; other site 1048834007969 30S ribosomal protein S11; Validated; Region: PRK05309 1048834007970 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1048834007971 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1048834007972 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1048834007973 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1048834007974 rRNA binding site [nucleotide binding]; other site 1048834007975 predicted 30S ribosome binding site; other site 1048834007976 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 1048834007977 RNA binding site [nucleotide binding]; other site 1048834007978 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1048834007979 adenylate kinase; Reviewed; Region: adk; PRK00279 1048834007980 AMP-binding site [chemical binding]; other site 1048834007981 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1048834007982 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1048834007983 SecY translocase; Region: SecY; pfam00344 1048834007984 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1048834007985 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1048834007986 23S rRNA binding site [nucleotide binding]; other site 1048834007987 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1048834007988 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1048834007989 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1048834007990 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1048834007991 5S rRNA interface [nucleotide binding]; other site 1048834007992 L27 interface [polypeptide binding]; other site 1048834007993 23S rRNA interface [nucleotide binding]; other site 1048834007994 L5 interface [polypeptide binding]; other site 1048834007995 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1048834007996 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1048834007997 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1048834007998 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1048834007999 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1048834008000 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1048834008001 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1048834008002 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1048834008003 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1048834008004 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1048834008005 RNA binding site [nucleotide binding]; other site 1048834008006 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1048834008007 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1048834008008 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1048834008009 23S rRNA interface [nucleotide binding]; other site 1048834008010 putative translocon interaction site; other site 1048834008011 signal recognition particle (SRP54) interaction site; other site 1048834008012 L23 interface [polypeptide binding]; other site 1048834008013 trigger factor interaction site; other site 1048834008014 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1048834008015 23S rRNA interface [nucleotide binding]; other site 1048834008016 5S rRNA interface [nucleotide binding]; other site 1048834008017 putative antibiotic binding site [chemical binding]; other site 1048834008018 L25 interface [polypeptide binding]; other site 1048834008019 L27 interface [polypeptide binding]; other site 1048834008020 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1048834008021 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1048834008022 G-X-X-G motif; other site 1048834008023 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1048834008024 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1048834008025 putative translocon binding site; other site 1048834008026 protein-rRNA interface [nucleotide binding]; other site 1048834008027 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1048834008028 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1048834008029 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1048834008030 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1048834008031 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1048834008032 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1048834008033 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1048834008034 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1048834008035 elongation factor Tu; Reviewed; Region: PRK00049 1048834008036 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1048834008037 G1 box; other site 1048834008038 GEF interaction site [polypeptide binding]; other site 1048834008039 GTP/Mg2+ binding site [chemical binding]; other site 1048834008040 Switch I region; other site 1048834008041 G2 box; other site 1048834008042 G3 box; other site 1048834008043 Switch II region; other site 1048834008044 G4 box; other site 1048834008045 G5 box; other site 1048834008046 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1048834008047 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1048834008048 Antibiotic Binding Site [chemical binding]; other site 1048834008049 elongation factor G; Reviewed; Region: PRK00007 1048834008050 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1048834008051 G1 box; other site 1048834008052 putative GEF interaction site [polypeptide binding]; other site 1048834008053 GTP/Mg2+ binding site [chemical binding]; other site 1048834008054 Switch I region; other site 1048834008055 G2 box; other site 1048834008056 G3 box; other site 1048834008057 Switch II region; other site 1048834008058 G4 box; other site 1048834008059 G5 box; other site 1048834008060 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1048834008061 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1048834008062 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1048834008063 30S ribosomal protein S7; Validated; Region: PRK05302 1048834008064 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1048834008065 S17 interaction site [polypeptide binding]; other site 1048834008066 S8 interaction site; other site 1048834008067 16S rRNA interaction site [nucleotide binding]; other site 1048834008068 streptomycin interaction site [chemical binding]; other site 1048834008069 23S rRNA interaction site [nucleotide binding]; other site 1048834008070 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1048834008071 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1048834008072 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1048834008073 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1048834008074 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1048834008075 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1048834008076 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1048834008077 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1048834008078 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1048834008079 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1048834008080 G-loop; other site 1048834008081 DNA binding site [nucleotide binding] 1048834008082 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 1048834008083 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1048834008084 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1048834008085 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1048834008086 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1048834008087 RPB10 interaction site [polypeptide binding]; other site 1048834008088 RPB1 interaction site [polypeptide binding]; other site 1048834008089 RPB11 interaction site [polypeptide binding]; other site 1048834008090 RPB3 interaction site [polypeptide binding]; other site 1048834008091 RPB12 interaction site [polypeptide binding]; other site 1048834008092 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1048834008093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834008094 S-adenosylmethionine binding site [chemical binding]; other site 1048834008095 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1048834008096 core dimer interface [polypeptide binding]; other site 1048834008097 peripheral dimer interface [polypeptide binding]; other site 1048834008098 L10 interface [polypeptide binding]; other site 1048834008099 L11 interface [polypeptide binding]; other site 1048834008100 putative EF-Tu interaction site [polypeptide binding]; other site 1048834008101 putative EF-G interaction site [polypeptide binding]; other site 1048834008102 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1048834008103 23S rRNA interface [nucleotide binding]; other site 1048834008104 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1048834008105 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1048834008106 mRNA/rRNA interface [nucleotide binding]; other site 1048834008107 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1048834008108 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1048834008109 putative thiostrepton binding site; other site 1048834008110 23S rRNA interface [nucleotide binding]; other site 1048834008111 L7/L12 interface [polypeptide binding]; other site 1048834008112 L25 interface [polypeptide binding]; other site 1048834008113 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1048834008114 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1048834008115 putative homodimer interface [polypeptide binding]; other site 1048834008116 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1048834008117 heterodimer interface [polypeptide binding]; other site 1048834008118 homodimer interface [polypeptide binding]; other site 1048834008119 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1048834008120 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1048834008121 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1048834008122 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1048834008123 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1048834008124 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1048834008125 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1048834008126 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1048834008127 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1048834008128 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1048834008129 active site 1048834008130 metal binding site [ion binding]; metal-binding site 1048834008131 dimerization interface [polypeptide binding]; other site 1048834008132 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1048834008133 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1048834008134 active site 1048834008135 HIGH motif; other site 1048834008136 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1048834008137 KMSKS motif; other site 1048834008138 tRNA binding surface [nucleotide binding]; other site 1048834008139 anticodon binding site; other site 1048834008140 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 1048834008141 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1048834008142 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1048834008143 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1048834008144 active site 1048834008145 KMSKS motif; other site 1048834008146 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1048834008147 homotrimer interaction site [polypeptide binding]; other site 1048834008148 zinc binding site [ion binding]; other site 1048834008149 CDP-binding sites; other site 1048834008150 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1048834008151 substrate binding site; other site 1048834008152 dimer interface; other site 1048834008153 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1048834008154 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1048834008155 putative active site [active] 1048834008156 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1048834008157 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1048834008158 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1048834008159 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1048834008160 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1048834008161 DNA repair protein RadA; Provisional; Region: PRK11823 1048834008162 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1048834008163 Walker A motif/ATP binding site; other site 1048834008164 ATP binding site [chemical binding]; other site 1048834008165 Walker B motif; other site 1048834008166 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1048834008167 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1048834008168 Clp amino terminal domain; Region: Clp_N; pfam02861 1048834008169 Clp amino terminal domain; Region: Clp_N; pfam02861 1048834008170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834008171 Walker A motif; other site 1048834008172 ATP binding site [chemical binding]; other site 1048834008173 Walker B motif; other site 1048834008174 arginine finger; other site 1048834008175 UvrB/uvrC motif; Region: UVR; pfam02151 1048834008176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834008177 Walker A motif; other site 1048834008178 ATP binding site [chemical binding]; other site 1048834008179 Walker B motif; other site 1048834008180 arginine finger; other site 1048834008181 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1048834008182 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1048834008183 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1048834008184 ADP binding site [chemical binding]; other site 1048834008185 phosphagen binding site; other site 1048834008186 substrate specificity loop; other site 1048834008187 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1048834008188 UvrB/uvrC motif; Region: UVR; pfam02151 1048834008189 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1048834008190 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1048834008191 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1048834008192 Integrase core domain; Region: rve; pfam00665 1048834008193 transposase/IS protein; Provisional; Region: PRK09183 1048834008194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1048834008195 Walker A motif; other site 1048834008196 ATP binding site [chemical binding]; other site 1048834008197 Walker B motif; other site 1048834008198 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1048834008199 DNA binding residues [nucleotide binding] 1048834008200 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1048834008201 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1048834008202 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1048834008203 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1048834008204 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1048834008205 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 1048834008206 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1048834008207 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1048834008208 MreB and similar proteins; Region: MreB_like; cd10225 1048834008209 nucleotide binding site [chemical binding]; other site 1048834008210 Mg binding site [ion binding]; other site 1048834008211 putative protofilament interaction site [polypeptide binding]; other site 1048834008212 RodZ interaction site [polypeptide binding]; other site 1048834008213 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1048834008214 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1048834008215 Peptidase family M23; Region: Peptidase_M23; pfam01551 1048834008216 Stage II sporulation protein; Region: SpoIID; pfam08486 1048834008217 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1048834008218 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1048834008219 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1048834008220 hinge; other site 1048834008221 active site 1048834008222 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1048834008223 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1048834008224 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1048834008225 gamma subunit interface [polypeptide binding]; other site 1048834008226 epsilon subunit interface [polypeptide binding]; other site 1048834008227 LBP interface [polypeptide binding]; other site 1048834008228 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1048834008229 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1048834008230 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1048834008231 alpha subunit interaction interface [polypeptide binding]; other site 1048834008232 Walker A motif; other site 1048834008233 ATP binding site [chemical binding]; other site 1048834008234 Walker B motif; other site 1048834008235 inhibitor binding site; inhibition site 1048834008236 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1048834008237 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1048834008238 core domain interface [polypeptide binding]; other site 1048834008239 delta subunit interface [polypeptide binding]; other site 1048834008240 epsilon subunit interface [polypeptide binding]; other site 1048834008241 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1048834008242 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1048834008243 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1048834008244 beta subunit interaction interface [polypeptide binding]; other site 1048834008245 Walker A motif; other site 1048834008246 ATP binding site [chemical binding]; other site 1048834008247 Walker B motif; other site 1048834008248 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1048834008249 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1048834008250 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1048834008251 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1048834008252 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1048834008253 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1048834008254 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1048834008255 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1048834008256 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1048834008257 active site 1048834008258 homodimer interface [polypeptide binding]; other site 1048834008259 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1048834008260 active site 1048834008261 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1048834008262 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1048834008263 dimer interface [polypeptide binding]; other site 1048834008264 active site 1048834008265 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1048834008266 folate binding site [chemical binding]; other site 1048834008267 hypothetical protein; Provisional; Region: PRK13690 1048834008268 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1048834008269 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1048834008270 Predicted membrane protein [Function unknown]; Region: COG1971 1048834008271 Domain of unknown function DUF; Region: DUF204; pfam02659 1048834008272 Domain of unknown function DUF; Region: DUF204; pfam02659 1048834008273 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1048834008274 NlpC/P60 family; Region: NLPC_P60; cl17555 1048834008275 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1048834008276 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1048834008277 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1048834008278 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 1048834008279 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1048834008280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834008281 S-adenosylmethionine binding site [chemical binding]; other site 1048834008282 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1048834008283 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1048834008284 RF-1 domain; Region: RF-1; pfam00472 1048834008285 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1048834008286 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1048834008287 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1048834008288 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1048834008289 RNA binding site [nucleotide binding]; other site 1048834008290 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1048834008291 multimer interface [polypeptide binding]; other site 1048834008292 Walker A motif; other site 1048834008293 ATP binding site [chemical binding]; other site 1048834008294 Walker B motif; other site 1048834008295 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1048834008296 active site 1048834008297 intersubunit interactions; other site 1048834008298 catalytic residue [active] 1048834008299 Response regulator receiver domain; Region: Response_reg; pfam00072 1048834008300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834008301 active site 1048834008302 phosphorylation site [posttranslational modification] 1048834008303 intermolecular recognition site; other site 1048834008304 dimerization interface [polypeptide binding]; other site 1048834008305 CTP synthetase; Validated; Region: pyrG; PRK05380 1048834008306 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1048834008307 Catalytic site [active] 1048834008308 active site 1048834008309 UTP binding site [chemical binding]; other site 1048834008310 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1048834008311 active site 1048834008312 putative oxyanion hole; other site 1048834008313 catalytic triad [active] 1048834008314 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 1048834008315 enoyl-CoA hydratase; Provisional; Region: PRK07658 1048834008316 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1048834008317 substrate binding site [chemical binding]; other site 1048834008318 oxyanion hole (OAH) forming residues; other site 1048834008319 trimer interface [polypeptide binding]; other site 1048834008320 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1048834008321 putative active site [active] 1048834008322 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 1048834008323 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1048834008324 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1048834008325 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1048834008326 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1048834008327 active site 1048834008328 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1048834008329 agmatinase; Region: agmatinase; TIGR01230 1048834008330 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1048834008331 putative active site [active] 1048834008332 Mn binding site [ion binding]; other site 1048834008333 spermidine synthase; Provisional; Region: PRK00811 1048834008334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834008335 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1048834008336 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1048834008337 active site 1048834008338 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1048834008339 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1048834008340 NAD(P) binding site [chemical binding]; other site 1048834008341 Transglycosylase; Region: Transgly; pfam00912 1048834008342 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1048834008343 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1048834008344 aspartate aminotransferase; Provisional; Region: PRK05764 1048834008345 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048834008346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834008347 homodimer interface [polypeptide binding]; other site 1048834008348 catalytic residue [active] 1048834008349 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570 1048834008350 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1048834008351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1048834008352 FeS/SAM binding site; other site 1048834008353 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1048834008354 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1048834008355 active site 1048834008356 dimer interfaces [polypeptide binding]; other site 1048834008357 catalytic residues [active] 1048834008358 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1048834008359 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1048834008360 active site 1048834008361 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1048834008362 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1048834008363 putative acetyltransferase; Provisional; Region: PRK03624 1048834008364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048834008365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1048834008366 Coenzyme A binding pocket [chemical binding]; other site 1048834008367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1048834008368 Coenzyme A binding pocket [chemical binding]; other site 1048834008369 Domain of unknown function DUF77; Region: DUF77; pfam01910 1048834008370 D-galactonate transporter; Region: 2A0114; TIGR00893 1048834008371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834008372 putative substrate translocation pore; other site 1048834008373 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1048834008374 N- and C-terminal domain interface [polypeptide binding]; other site 1048834008375 active site 1048834008376 catalytic site [active] 1048834008377 metal binding site [ion binding]; metal-binding site 1048834008378 carbohydrate binding site [chemical binding]; other site 1048834008379 ATP binding site [chemical binding]; other site 1048834008380 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1048834008381 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1048834008382 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1048834008383 catalytic residue [active] 1048834008384 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834008385 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1048834008386 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1048834008387 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1048834008388 GTP cyclohydrolase I; Provisional; Region: PLN03044 1048834008389 active site 1048834008390 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1048834008391 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1048834008392 substrate binding pocket [chemical binding]; other site 1048834008393 chain length determination region; other site 1048834008394 substrate-Mg2+ binding site; other site 1048834008395 catalytic residues [active] 1048834008396 aspartate-rich region 1; other site 1048834008397 active site lid residues [active] 1048834008398 aspartate-rich region 2; other site 1048834008399 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1048834008400 active site lid residues [active] 1048834008401 substrate binding pocket [chemical binding]; other site 1048834008402 catalytic residues [active] 1048834008403 substrate-Mg2+ binding site; other site 1048834008404 aspartate-rich region 1; other site 1048834008405 aspartate-rich region 2; other site 1048834008406 phytoene desaturase; Region: crtI_fam; TIGR02734 1048834008407 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1048834008408 Cytochrome P450; Region: p450; cl12078 1048834008409 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1048834008410 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1048834008411 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1048834008412 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 1048834008413 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1048834008414 DXD motif; other site 1048834008415 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1048834008416 conjugal transfer ATPase TrbB; Provisional; Region: PRK13894 1048834008417 DinB superfamily; Region: DinB_2; pfam12867 1048834008418 DinB family; Region: DinB; cl17821 1048834008419 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1048834008420 Phosphotransferase enzyme family; Region: APH; pfam01636 1048834008421 active site 1048834008422 substrate binding site [chemical binding]; other site 1048834008423 ATP binding site [chemical binding]; other site 1048834008424 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1048834008425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834008426 putative substrate translocation pore; other site 1048834008427 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1048834008428 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048834008429 DNA binding site [nucleotide binding] 1048834008430 domain linker motif; other site 1048834008431 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1048834008432 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1048834008433 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1048834008434 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1048834008435 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1048834008436 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1048834008437 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1048834008438 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1048834008439 active site 1048834008440 trimer interface [polypeptide binding]; other site 1048834008441 substrate binding site [chemical binding]; other site 1048834008442 CoA binding site [chemical binding]; other site 1048834008443 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1048834008444 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1048834008445 metal binding site [ion binding]; metal-binding site 1048834008446 putative dimer interface [polypeptide binding]; other site 1048834008447 aminotransferase A; Validated; Region: PRK07683 1048834008448 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1048834008449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1048834008450 homodimer interface [polypeptide binding]; other site 1048834008451 catalytic residue [active] 1048834008452 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 1048834008453 polypeptide substrate binding site [polypeptide binding]; other site 1048834008454 active site 1048834008455 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1048834008456 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1048834008457 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1048834008458 NAD(P) binding pocket [chemical binding]; other site 1048834008459 potential frameshift: common BLAST hit: gi|258512800|ref|YP_003186234.1| ABC transporter-like protein 1048834008460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834008461 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1048834008462 ABC transporter signature motif; other site 1048834008463 Walker B; other site 1048834008464 D-loop; other site 1048834008465 H-loop/switch region; other site 1048834008466 TOBE domain; Region: TOBE_2; pfam08402 1048834008467 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1048834008468 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1048834008469 Walker A/P-loop; other site 1048834008470 ATP binding site [chemical binding]; other site 1048834008471 Q-loop/lid; other site 1048834008472 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1048834008473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834008474 dimer interface [polypeptide binding]; other site 1048834008475 conserved gate region; other site 1048834008476 putative PBP binding loops; other site 1048834008477 ABC-ATPase subunit interface; other site 1048834008478 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1048834008479 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1048834008480 DNA binding residues [nucleotide binding] 1048834008481 putative dimer interface [polypeptide binding]; other site 1048834008482 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1048834008483 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1048834008484 active site 1048834008485 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1048834008486 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1048834008487 acyl-activating enzyme (AAE) consensus motif; other site 1048834008488 AMP binding site [chemical binding]; other site 1048834008489 active site 1048834008490 CoA binding site [chemical binding]; other site 1048834008491 biotin synthase; Validated; Region: PRK06256 1048834008492 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1048834008493 hypothetical protein; Provisional; Region: PRK06753 1048834008494 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1048834008495 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1048834008496 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1048834008497 Walker A/P-loop; other site 1048834008498 ATP binding site [chemical binding]; other site 1048834008499 Q-loop/lid; other site 1048834008500 ABC transporter signature motif; other site 1048834008501 Walker B; other site 1048834008502 D-loop; other site 1048834008503 H-loop/switch region; other site 1048834008504 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1048834008505 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1048834008506 NAD(P) binding site [chemical binding]; other site 1048834008507 substrate binding site [chemical binding]; other site 1048834008508 dimer interface [polypeptide binding]; other site 1048834008509 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1048834008510 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1048834008511 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 1048834008512 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1048834008513 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1048834008514 L-asparaginase II; Region: Asparaginase_II; pfam06089 1048834008515 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048834008516 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048834008517 metal binding site [ion binding]; metal-binding site 1048834008518 active site 1048834008519 I-site; other site 1048834008520 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1048834008521 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1048834008522 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 1048834008523 trimer interface [polypeptide binding]; other site 1048834008524 active site 1048834008525 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 1048834008526 catalytic site [active] 1048834008527 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1048834008528 active site 1048834008529 homodimer interface [polypeptide binding]; other site 1048834008530 catalytic site [active] 1048834008531 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1048834008532 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1048834008533 DNA binding site [nucleotide binding] 1048834008534 domain linker motif; other site 1048834008535 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1048834008536 putative dimerization interface [polypeptide binding]; other site 1048834008537 putative ligand binding site [chemical binding]; other site 1048834008538 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1048834008539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834008540 dimer interface [polypeptide binding]; other site 1048834008541 conserved gate region; other site 1048834008542 putative PBP binding loops; other site 1048834008543 ABC-ATPase subunit interface; other site 1048834008544 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1048834008545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834008546 dimer interface [polypeptide binding]; other site 1048834008547 conserved gate region; other site 1048834008548 putative PBP binding loops; other site 1048834008549 ABC-ATPase subunit interface; other site 1048834008550 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1048834008551 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1048834008552 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1048834008553 homodimer interface [polypeptide binding]; other site 1048834008554 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1048834008555 homodimer interface [polypeptide binding]; other site 1048834008556 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1048834008557 active site 1048834008558 homodimer interface [polypeptide binding]; other site 1048834008559 catalytic site [active] 1048834008560 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1048834008561 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1048834008562 Pirin-related protein [General function prediction only]; Region: COG1741 1048834008563 Pirin; Region: Pirin; pfam02678 1048834008564 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1048834008565 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1048834008566 nudix motif; other site 1048834008567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834008568 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1048834008569 putative substrate translocation pore; other site 1048834008570 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1048834008571 dimerization interface [polypeptide binding]; other site 1048834008572 putative DNA binding site [nucleotide binding]; other site 1048834008573 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1048834008574 putative Zn2+ binding site [ion binding]; other site 1048834008575 phosphate:H+ symporter; Region: 2A0109; TIGR00887 1048834008576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834008577 putative substrate translocation pore; other site 1048834008578 Predicted membrane protein [Function unknown]; Region: COG3817 1048834008579 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1048834008580 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1048834008581 DNA binding residues [nucleotide binding] 1048834008582 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1048834008583 catalytic residues [active] 1048834008584 catalytic nucleophile [active] 1048834008585 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1048834008586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1048834008587 Probable transposase; Region: OrfB_IS605; pfam01385 1048834008588 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1048834008589 Predicted membrane protein [Function unknown]; Region: COG3817 1048834008590 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1048834008591 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1048834008592 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1048834008593 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 1048834008594 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 1048834008595 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1048834008596 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1048834008597 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1048834008598 putative catalytic cysteine [active] 1048834008599 gamma-glutamyl kinase; Provisional; Region: PRK05429 1048834008600 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1048834008601 nucleotide binding site [chemical binding]; other site 1048834008602 homotetrameric interface [polypeptide binding]; other site 1048834008603 putative phosphate binding site [ion binding]; other site 1048834008604 putative allosteric binding site; other site 1048834008605 PUA domain; Region: PUA; pfam01472 1048834008606 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1048834008607 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1048834008608 putative alpha-glucosidase; Provisional; Region: PRK10658 1048834008609 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1048834008610 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1048834008611 active site 1048834008612 homotrimer interface [polypeptide binding]; other site 1048834008613 catalytic site [active] 1048834008614 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1048834008615 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1048834008616 Ligand Binding Site [chemical binding]; other site 1048834008617 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1048834008618 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1048834008619 Cupin domain; Region: Cupin_2; pfam07883 1048834008620 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1048834008621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048834008622 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1048834008623 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1048834008624 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1048834008625 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1048834008626 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1048834008627 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1048834008628 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1048834008629 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1048834008630 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1048834008631 DNA binding site [nucleotide binding] 1048834008632 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1048834008633 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1048834008634 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1048834008635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834008636 dimer interface [polypeptide binding]; other site 1048834008637 conserved gate region; other site 1048834008638 putative PBP binding loops; other site 1048834008639 ABC-ATPase subunit interface; other site 1048834008640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1048834008641 dimer interface [polypeptide binding]; other site 1048834008642 conserved gate region; other site 1048834008643 putative PBP binding loops; other site 1048834008644 ABC-ATPase subunit interface; other site 1048834008645 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1048834008646 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1048834008647 Predicted transcriptional regulator [Transcription]; Region: COG4189 1048834008648 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1048834008649 dimerization interface [polypeptide binding]; other site 1048834008650 putative DNA binding site [nucleotide binding]; other site 1048834008651 putative Zn2+ binding site [ion binding]; other site 1048834008652 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1048834008653 active site 1048834008654 metal binding site [ion binding]; metal-binding site 1048834008655 L-arabinose isomerase; Provisional; Region: PRK02929 1048834008656 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1048834008657 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1048834008658 trimer interface [polypeptide binding]; other site 1048834008659 putative substrate binding site [chemical binding]; other site 1048834008660 putative metal binding site [ion binding]; other site 1048834008661 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1048834008662 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1048834008663 intersubunit interface [polypeptide binding]; other site 1048834008664 active site 1048834008665 Zn2+ binding site [ion binding]; other site 1048834008666 ribulokinase; Provisional; Region: PRK04123 1048834008667 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1048834008668 N- and C-terminal domain interface [polypeptide binding]; other site 1048834008669 active site 1048834008670 MgATP binding site [chemical binding]; other site 1048834008671 catalytic site [active] 1048834008672 metal binding site [ion binding]; metal-binding site 1048834008673 carbohydrate binding site [chemical binding]; other site 1048834008674 homodimer interface [polypeptide binding]; other site 1048834008675 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1048834008676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834008677 putative substrate translocation pore; other site 1048834008678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834008679 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1048834008680 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1048834008681 DNA-binding site [nucleotide binding]; DNA binding site 1048834008682 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 1048834008683 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1048834008684 putative ligand binding site [chemical binding]; other site 1048834008685 putative dimerization interface [polypeptide binding]; other site 1048834008686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834008687 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1048834008688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1048834008689 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1048834008690 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1048834008691 dimer interface [polypeptide binding]; other site 1048834008692 FMN binding site [chemical binding]; other site 1048834008693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1048834008694 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1048834008695 putative substrate translocation pore; other site 1048834008696 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1048834008697 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1048834008698 E3 interaction surface; other site 1048834008699 lipoyl attachment site [posttranslational modification]; other site 1048834008700 HlyD family secretion protein; Region: HlyD_3; pfam13437 1048834008701 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1048834008702 HSP70 interaction site [polypeptide binding]; other site 1048834008703 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1048834008704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1048834008705 NAD(P) binding site [chemical binding]; other site 1048834008706 active site 1048834008707 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048834008708 putative active site [active] 1048834008709 heme pocket [chemical binding]; other site 1048834008710 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1048834008711 PAS fold; Region: PAS_3; pfam08447 1048834008712 putative active site [active] 1048834008713 heme pocket [chemical binding]; other site 1048834008714 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1048834008715 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1048834008716 metal binding site [ion binding]; metal-binding site 1048834008717 active site 1048834008718 I-site; other site 1048834008719 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1048834008720 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1048834008721 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cd09299 1048834008722 gating phenylalanine in ion channel; other site 1048834008723 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 1048834008724 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1048834008725 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1048834008726 putative dimerization interface [polypeptide binding]; other site 1048834008727 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1048834008728 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1048834008729 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1048834008730 protein binding site [polypeptide binding]; other site 1048834008731 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1048834008732 YycH protein; Region: YycI; cl02015 1048834008733 YycH protein; Region: YycH; pfam07435 1048834008734 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1048834008735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1048834008736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1048834008737 dimerization interface [polypeptide binding]; other site 1048834008738 PAS domain; Region: PAS; smart00091 1048834008739 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1048834008740 dimer interface [polypeptide binding]; other site 1048834008741 phosphorylation site [posttranslational modification] 1048834008742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1048834008743 ATP binding site [chemical binding]; other site 1048834008744 Mg2+ binding site [ion binding]; other site 1048834008745 G-X-G motif; other site 1048834008746 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1048834008747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1048834008748 active site 1048834008749 phosphorylation site [posttranslational modification] 1048834008750 intermolecular recognition site; other site 1048834008751 dimerization interface [polypeptide binding]; other site 1048834008752 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1048834008753 DNA binding site [nucleotide binding] 1048834008754 replicative DNA helicase; Region: DnaB; TIGR00665 1048834008755 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1048834008756 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1048834008757 Walker A motif; other site 1048834008758 ATP binding site [chemical binding]; other site 1048834008759 Walker B motif; other site 1048834008760 DNA binding loops [nucleotide binding] 1048834008761 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1048834008762 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1048834008763 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1048834008764 MazG-like family; Region: MazG-like; pfam12643 1048834008765 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1048834008766 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1048834008767 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1048834008768 dimer interface [polypeptide binding]; other site 1048834008769 ssDNA binding site [nucleotide binding]; other site 1048834008770 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1048834008771 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1048834008772 GTP-binding protein YchF; Reviewed; Region: PRK09601 1048834008773 YchF GTPase; Region: YchF; cd01900 1048834008774 G1 box; other site 1048834008775 GTP/Mg2+ binding site [chemical binding]; other site 1048834008776 Switch I region; other site 1048834008777 G2 box; other site 1048834008778 Switch II region; other site 1048834008779 G3 box; other site 1048834008780 G4 box; other site 1048834008781 G5 box; other site 1048834008782 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1048834008783 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1048834008784 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1048834008785 putative [4Fe-4S] binding site [ion binding]; other site 1048834008786 putative molybdopterin cofactor binding site [chemical binding]; other site 1048834008787 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1048834008788 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1048834008789 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1048834008790 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1048834008791 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 1048834008792 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1048834008793 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1048834008794 ParB-like nuclease domain; Region: ParB; smart00470 1048834008795 KorB domain; Region: KorB; pfam08535 1048834008796 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1048834008797 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1048834008798 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1048834008799 ParB-like nuclease domain; Region: ParB; smart00470 1048834008800 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1048834008801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1048834008802 S-adenosylmethionine binding site [chemical binding]; other site 1048834008803 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1048834008804 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1048834008805 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1048834008806 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1048834008807 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1048834008808 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1048834008809 G1 box; other site 1048834008810 GTP/Mg2+ binding site [chemical binding]; other site 1048834008811 Switch I region; other site 1048834008812 G2 box; other site 1048834008813 Switch II region; other site 1048834008814 G3 box; other site 1048834008815 G4 box; other site 1048834008816 G5 box; other site 1048834008817 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1048834008818 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1048834008819 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1048834008820 G-X-X-G motif; other site 1048834008821 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1048834008822 RxxxH motif; other site 1048834008823 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1048834008824 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1048834008825 Haemolytic domain; Region: Haemolytic; pfam01809 1048834008826 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1048834008827 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399