-- dump date   	20140618_194252
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
293826000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
293826000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
293826000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826000004	Walker A motif; other site
293826000005	ATP binding site [chemical binding]; other site
293826000006	Walker B motif; other site
293826000007	arginine finger; other site
293826000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
293826000009	DnaA box-binding interface [nucleotide binding]; other site
293826000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
293826000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
293826000012	putative DNA binding surface [nucleotide binding]; other site
293826000013	dimer interface [polypeptide binding]; other site
293826000014	beta-clamp/clamp loader binding surface; other site
293826000015	beta-clamp/translesion DNA polymerase binding surface; other site
293826000016	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
293826000017	RNA binding surface [nucleotide binding]; other site
293826000018	recombination protein F; Reviewed; Region: recF; PRK00064
293826000019	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
293826000020	Walker A/P-loop; other site
293826000021	ATP binding site [chemical binding]; other site
293826000022	Q-loop/lid; other site
293826000023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826000024	ABC transporter signature motif; other site
293826000025	Walker B; other site
293826000026	D-loop; other site
293826000027	H-loop/switch region; other site
293826000028	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
293826000029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826000030	Mg2+ binding site [ion binding]; other site
293826000031	G-X-G motif; other site
293826000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
293826000033	anchoring element; other site
293826000034	dimer interface [polypeptide binding]; other site
293826000035	ATP binding site [chemical binding]; other site
293826000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
293826000037	active site
293826000038	putative metal-binding site [ion binding]; other site
293826000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
293826000040	DNA gyrase subunit A; Validated; Region: PRK05560
293826000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
293826000042	CAP-like domain; other site
293826000043	active site
293826000044	primary dimer interface [polypeptide binding]; other site
293826000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
293826000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
293826000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
293826000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
293826000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
293826000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
293826000051	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
293826000052	anti sigma factor interaction site; other site
293826000053	regulatory phosphorylation site [posttranslational modification]; other site
293826000054	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
293826000055	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826000056	ATP binding site [chemical binding]; other site
293826000057	Mg2+ binding site [ion binding]; other site
293826000058	G-X-G motif; other site
293826000059	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
293826000060	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826000061	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
293826000062	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826000063	DNA binding residues [nucleotide binding]
293826000064	QueT transporter; Region: QueT; pfam06177
293826000065	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
293826000066	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
293826000067	tetramer interface [polypeptide binding]; other site
293826000068	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826000069	catalytic residue [active]
293826000070	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
293826000071	tetramer interface [polypeptide binding]; other site
293826000072	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826000073	catalytic residue [active]
293826000074	Quinolinate synthetase A protein; Region: NadA; pfam02445
293826000075	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
293826000076	L-aspartate oxidase; Provisional; Region: PRK06175
293826000077	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
293826000078	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
293826000079	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
293826000080	dimerization interface [polypeptide binding]; other site
293826000081	active site
293826000082	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
293826000083	HTH domain; Region: HTH_11; pfam08279
293826000084	3H domain; Region: 3H; pfam02829
293826000085	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
293826000086	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
293826000087	Uncharacterized conserved protein [Function unknown]; Region: COG1615
293826000088	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
293826000089	seryl-tRNA synthetase; Provisional; Region: PRK05431
293826000090	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
293826000091	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
293826000092	dimer interface [polypeptide binding]; other site
293826000093	active site
293826000094	motif 1; other site
293826000095	motif 2; other site
293826000096	motif 3; other site
293826000097	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
293826000098	nucleoside/Zn binding site; other site
293826000099	dimer interface [polypeptide binding]; other site
293826000100	catalytic motif [active]
293826000101	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
293826000102	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
293826000103	CPxP  motif; other site
293826000104	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
293826000105	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
293826000106	Mechanosensitive ion channel; Region: MS_channel; pfam00924
293826000107	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
293826000108	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
293826000109	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
293826000110	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826000111	homodimer interface [polypeptide binding]; other site
293826000112	catalytic residue [active]
293826000113	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
293826000114	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
293826000115	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
293826000116	dimer interface [polypeptide binding]; other site
293826000117	ssDNA binding site [nucleotide binding]; other site
293826000118	tetramer (dimer of dimers) interface [polypeptide binding]; other site
293826000119	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
293826000120	YibE/F-like protein; Region: YibE_F; pfam07907
293826000121	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
293826000122	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
293826000123	5S rRNA interface [nucleotide binding]; other site
293826000124	CTC domain interface [polypeptide binding]; other site
293826000125	L16 interface [polypeptide binding]; other site
293826000126	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
293826000127	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
293826000128	5S rRNA interface [nucleotide binding]; other site
293826000129	CTC domain interface [polypeptide binding]; other site
293826000130	L16 interface [polypeptide binding]; other site
293826000131	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
293826000132	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
293826000133	metal binding site [ion binding]; metal-binding site
293826000134	dimer interface [polypeptide binding]; other site
293826000135	Predicted membrane protein [Function unknown]; Region: COG1288
293826000136	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
293826000137	D-glutamate deacylase; Validated; Region: PRK09061
293826000138	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
293826000139	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
293826000140	active site
293826000141	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
293826000142	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
293826000143	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
293826000144	metal binding site [ion binding]; metal-binding site
293826000145	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
293826000146	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
293826000147	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826000148	dimer interface [polypeptide binding]; other site
293826000149	putative CheW interface [polypeptide binding]; other site
293826000150	Cache domain; Region: Cache_1; pfam02743
293826000151	Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152
293826000152	putative homodimer interface [polypeptide binding]; other site
293826000153	putative homotetramer interface [polypeptide binding]; other site
293826000154	allosteric switch controlling residues; other site
293826000155	putative metal binding site [ion binding]; other site
293826000156	putative homodimer-homodimer interface [polypeptide binding]; other site
293826000157	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
293826000158	metal-binding site [ion binding]
293826000159	YceG-like family; Region: YceG; pfam02618
293826000160	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
293826000161	dimerization interface [polypeptide binding]; other site
293826000162	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
293826000163	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
293826000164	ATP binding site [chemical binding]; other site
293826000165	substrate interface [chemical binding]; other site
293826000166	Uncharacterized conserved protein [Function unknown]; Region: COG0398
293826000167	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
293826000168	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
293826000169	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
293826000170	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
293826000171	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
293826000172	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
293826000173	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826000174	FeS/SAM binding site; other site
293826000175	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
293826000176	putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054
293826000177	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826000178	FeS/SAM binding site; other site
293826000179	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
293826000180	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
293826000181	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
293826000182	CPxP  motif; other site
293826000183	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
293826000184	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
293826000185	dimer interface [polypeptide binding]; other site
293826000186	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826000187	catalytic residue [active]
293826000188	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
293826000189	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
293826000190	homodimer interface [polypeptide binding]; other site
293826000191	substrate-cofactor binding pocket; other site
293826000192	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826000193	catalytic residue [active]
293826000194	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
293826000195	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
293826000196	tRNA; other site
293826000197	putative tRNA binding site [nucleotide binding]; other site
293826000198	putative NADP binding site [chemical binding]; other site
293826000199	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
293826000200	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
293826000201	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
293826000202	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
293826000203	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
293826000204	domain interfaces; other site
293826000205	active site
293826000206	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
293826000207	active site
293826000208	SAM binding site [chemical binding]; other site
293826000209	homodimer interface [polypeptide binding]; other site
293826000210	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
293826000211	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
293826000212	active site
293826000213	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
293826000214	dimer interface [polypeptide binding]; other site
293826000215	active site
293826000216	Schiff base residues; other site
293826000217	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
293826000218	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
293826000219	inhibitor-cofactor binding pocket; inhibition site
293826000220	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826000221	catalytic residue [active]
293826000222	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
293826000223	putative active site [active]
293826000224	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
293826000225	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
293826000226	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
293826000227	catalytic triad [active]
293826000228	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
293826000229	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
293826000230	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
293826000231	ATP binding site [chemical binding]; other site
293826000232	dimerization interface [polypeptide binding]; other site
293826000233	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
293826000234	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
293826000235	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
293826000236	Precorrin-8X methylmutase; Region: CbiC; pfam02570
293826000237	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
293826000238	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
293826000239	active site
293826000240	putative homodimer interface [polypeptide binding]; other site
293826000241	SAM binding site [chemical binding]; other site
293826000242	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
293826000243	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826000244	S-adenosylmethionine binding site [chemical binding]; other site
293826000245	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
293826000246	active site
293826000247	SAM binding site [chemical binding]; other site
293826000248	homodimer interface [polypeptide binding]; other site
293826000249	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
293826000250	active site
293826000251	SAM binding site [chemical binding]; other site
293826000252	homodimer interface [polypeptide binding]; other site
293826000253	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
293826000254	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
293826000255	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
293826000256	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
293826000257	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
293826000258	active site
293826000259	SAM binding site [chemical binding]; other site
293826000260	homodimer interface [polypeptide binding]; other site
293826000261	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
293826000262	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
293826000263	Inhibitor of sigma-G Gin; Region: Gin; pfam10764
293826000264	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
293826000265	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
293826000266	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
293826000267	catalytic residue [active]
293826000268	thymidylate kinase; Validated; Region: tmk; PRK00698
293826000269	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
293826000270	TMP-binding site; other site
293826000271	ATP-binding site [chemical binding]; other site
293826000272	Protein of unknown function (DUF970); Region: DUF970; pfam06153
293826000273	DNA polymerase III subunit delta'; Validated; Region: PRK08058
293826000274	DNA polymerase III subunit delta'; Validated; Region: PRK08485
293826000275	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
293826000276	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
293826000277	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
293826000278	catalytic residues [active]
293826000279	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
293826000280	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826000281	Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791
293826000282	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
293826000283	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826000284	S-adenosylmethionine binding site [chemical binding]; other site
293826000285	Predicted methyltransferases [General function prediction only]; Region: COG0313
293826000286	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
293826000287	putative SAM binding site [chemical binding]; other site
293826000288	putative homodimer interface [polypeptide binding]; other site
293826000289	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
293826000290	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
293826000291	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
293826000292	active site
293826000293	NTP binding site [chemical binding]; other site
293826000294	metal binding triad [ion binding]; metal-binding site
293826000295	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
293826000296	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826000297	Zn2+ binding site [ion binding]; other site
293826000298	Mg2+ binding site [ion binding]; other site
293826000299	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
293826000300	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
293826000301	active site
293826000302	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
293826000303	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
293826000304	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
293826000305	putative active site pocket [active]
293826000306	cleavage site
293826000307	Accessory gene regulator B; Region: AgrB; pfam04647
293826000308	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891
293826000309	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
293826000310	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
293826000311	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
293826000312	Walker A/P-loop; other site
293826000313	ATP binding site [chemical binding]; other site
293826000314	Q-loop/lid; other site
293826000315	ABC transporter signature motif; other site
293826000316	Walker B; other site
293826000317	D-loop; other site
293826000318	H-loop/switch region; other site
293826000319	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826000320	ATP binding site [chemical binding]; other site
293826000321	Mg2+ binding site [ion binding]; other site
293826000322	G-X-G motif; other site
293826000323	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
293826000324	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826000325	active site
293826000326	phosphorylation site [posttranslational modification]
293826000327	intermolecular recognition site; other site
293826000328	dimerization interface [polypeptide binding]; other site
293826000329	LytTr DNA-binding domain; Region: LytTR; smart00850
293826000330	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
293826000331	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826000332	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826000333	DNA binding residues [nucleotide binding]
293826000334	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
293826000335	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
293826000336	active site
293826000337	HIGH motif; other site
293826000338	KMSKS motif; other site
293826000339	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
293826000340	anticodon binding site; other site
293826000341	tRNA binding surface [nucleotide binding]; other site
293826000342	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
293826000343	dimer interface [polypeptide binding]; other site
293826000344	putative tRNA-binding site [nucleotide binding]; other site
293826000345	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
293826000346	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
293826000347	active site
293826000348	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
293826000349	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
293826000350	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
293826000351	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
293826000352	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
293826000353	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
293826000354	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
293826000355	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
293826000356	Transposase [DNA replication, recombination, and repair]; Region: COG5421
293826000357	Accessory gene regulator B; Region: AgrB; pfam04647
293826000358	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
293826000359	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
293826000360	dimerization interface [polypeptide binding]; other site
293826000361	putative DNA binding site [nucleotide binding]; other site
293826000362	putative Zn2+ binding site [ion binding]; other site
293826000363	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
293826000364	metal-binding site [ion binding]
293826000365	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
293826000366	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
293826000367	metal-binding site [ion binding]
293826000368	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
293826000369	Soluble P-type ATPase [General function prediction only]; Region: COG4087
293826000370	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
293826000371	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
293826000372	Predicted transcriptional regulators [Transcription]; Region: COG1725
293826000373	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826000374	DNA-binding site [nucleotide binding]; DNA binding site
293826000375	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
293826000376	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
293826000377	Walker A/P-loop; other site
293826000378	ATP binding site [chemical binding]; other site
293826000379	Q-loop/lid; other site
293826000380	ABC transporter signature motif; other site
293826000381	Walker B; other site
293826000382	D-loop; other site
293826000383	H-loop/switch region; other site
293826000384	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
293826000385	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
293826000386	Domain of unknown function (DUF348); Region: DUF348; pfam03990
293826000387	Domain of unknown function (DUF348); Region: DUF348; pfam03990
293826000388	G5 domain; Region: G5; pfam07501
293826000389	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
293826000390	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
293826000391	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
293826000392	putative active site [active]
293826000393	putative metal binding site [ion binding]; other site
293826000394	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
293826000395	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
293826000396	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826000397	S-adenosylmethionine binding site [chemical binding]; other site
293826000398	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
293826000399	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
293826000400	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
293826000401	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
293826000402	active site residue [active]
293826000403	Sporulation protein YtrH; Region: Spore_YtrH; pfam14034
293826000404	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
293826000405	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
293826000406	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
293826000407	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
293826000408	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
293826000409	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
293826000410	peptidase T-like protein; Region: PepT-like; TIGR01883
293826000411	metal binding site [ion binding]; metal-binding site
293826000412	putative dimer interface [polypeptide binding]; other site
293826000413	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
293826000414	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
293826000415	homodimer interface [polypeptide binding]; other site
293826000416	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826000417	catalytic residue [active]
293826000418	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
293826000419	Transcriptional regulator [Transcription]; Region: LytR; COG1316
293826000420	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
293826000421	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
293826000422	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
293826000423	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
293826000424	pur operon repressor; Provisional; Region: PRK09213
293826000425	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
293826000426	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
293826000427	active site
293826000428	regulatory protein SpoVG; Reviewed; Region: PRK13259
293826000429	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
293826000430	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
293826000431	Substrate binding site; other site
293826000432	Mg++ binding site; other site
293826000433	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
293826000434	active site
293826000435	substrate binding site [chemical binding]; other site
293826000436	CoA binding site [chemical binding]; other site
293826000437	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
293826000438	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
293826000439	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
293826000440	active site
293826000441	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
293826000442	putative active site [active]
293826000443	catalytic residue [active]
293826000444	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
293826000445	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
293826000446	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
293826000447	ATP binding site [chemical binding]; other site
293826000448	putative Mg++ binding site [ion binding]; other site
293826000449	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
293826000450	nucleotide binding region [chemical binding]; other site
293826000451	ATP-binding site [chemical binding]; other site
293826000452	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
293826000453	SurA N-terminal domain; Region: SurA_N_3; cl07813
293826000454	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
293826000455	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
293826000456	stage V sporulation protein T; Region: spore_V_T; TIGR02851
293826000457	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
293826000458	stage V sporulation protein B; Region: spore_V_B; TIGR02900
293826000459	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
293826000460	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
293826000461	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
293826000462	putative SAM binding site [chemical binding]; other site
293826000463	putative homodimer interface [polypeptide binding]; other site
293826000464	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
293826000465	homodimer interface [polypeptide binding]; other site
293826000466	metal binding site [ion binding]; metal-binding site
293826000467	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
293826000468	homodimer interface [polypeptide binding]; other site
293826000469	active site
293826000470	putative chemical substrate binding site [chemical binding]; other site
293826000471	metal binding site [ion binding]; metal-binding site
293826000472	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
293826000473	IHF dimer interface [polypeptide binding]; other site
293826000474	IHF - DNA interface [nucleotide binding]; other site
293826000475	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
293826000476	RNA binding surface [nucleotide binding]; other site
293826000477	Stage II sporulation protein; Region: SpoIID; pfam08486
293826000478	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
293826000479	YabP family; Region: YabP; cl06766
293826000480	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578
293826000481	Septum formation initiator; Region: DivIC; cl17659
293826000482	hypothetical protein; Provisional; Region: PRK05807
293826000483	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
293826000484	RNA binding site [nucleotide binding]; other site
293826000485	stage II sporulation protein E; Region: spore_II_E; TIGR02865
293826000486	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
293826000487	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826000488	non-specific DNA binding site [nucleotide binding]; other site
293826000489	salt bridge; other site
293826000490	sequence-specific DNA binding site [nucleotide binding]; other site
293826000491	Helix-turn-helix; Region: HTH_3; pfam01381
293826000492	sequence-specific DNA binding site [nucleotide binding]; other site
293826000493	salt bridge; other site
293826000494	seryl-tRNA synthetase; Provisional; Region: PRK05431
293826000495	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
293826000496	C-terminal peptidase (prc); Region: prc; TIGR00225
293826000497	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
293826000498	protein binding site [polypeptide binding]; other site
293826000499	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
293826000500	Catalytic dyad [active]
293826000501	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
293826000502	S-layer homology domain; Region: SLH; pfam00395
293826000503	S-layer homology domain; Region: SLH; pfam00395
293826000504	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
293826000505	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
293826000506	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
293826000507	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
293826000508	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
293826000509	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
293826000510	Interdomain contacts; other site
293826000511	Cytokine receptor motif; other site
293826000512	S-layer homology domain; Region: SLH; pfam00395
293826000513	S-layer homology domain; Region: SLH; pfam00395
293826000514	S-layer homology domain; Region: SLH; pfam00395
293826000515	CTP synthetase; Validated; Region: pyrG; PRK05380
293826000516	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
293826000517	Catalytic site [active]
293826000518	active site
293826000519	UTP binding site [chemical binding]; other site
293826000520	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
293826000521	active site
293826000522	putative oxyanion hole; other site
293826000523	catalytic triad [active]
293826000524	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
293826000525	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
293826000526	Outer membrane efflux protein; Region: OEP; pfam02321
293826000527	Outer membrane efflux protein; Region: OEP; pfam02321
293826000528	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
293826000529	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
293826000530	HlyD family secretion protein; Region: HlyD_3; pfam13437
293826000531	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
293826000532	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
293826000533	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
293826000534	Lamin Tail Domain; Region: LTD; pfam00932
293826000535	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
293826000536	CotH protein; Region: CotH; pfam08757
293826000537	S-layer homology domain; Region: SLH; pfam00395
293826000538	S-layer homology domain; Region: SLH; pfam00395
293826000539	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
293826000540	Chain length determinant protein; Region: Wzz; pfam02706
293826000541	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
293826000542	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
293826000543	O-Antigen ligase; Region: Wzy_C; pfam04932
293826000544	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826000545	TPR motif; other site
293826000546	Tetratricopeptide repeat; Region: TPR_12; pfam13424
293826000547	binding surface
293826000548	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
293826000549	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
293826000550	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
293826000551	active site
293826000552	NTP binding site [chemical binding]; other site
293826000553	metal binding triad [ion binding]; metal-binding site
293826000554	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
293826000555	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
293826000556	putative glycosyl transferase; Provisional; Region: PRK10307
293826000557	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
293826000558	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
293826000559	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
293826000560	NAD(P) binding site [chemical binding]; other site
293826000561	active site
293826000562	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
293826000563	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
293826000564	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
293826000565	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
293826000566	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
293826000567	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
293826000568	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
293826000569	active site
293826000570	homodimer interface [polypeptide binding]; other site
293826000571	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
293826000572	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
293826000573	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
293826000574	O-Antigen ligase; Region: Wzy_C; pfam04932
293826000575	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
293826000576	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
293826000577	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
293826000578	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
293826000579	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
293826000580	Domain of unknown function (DUF4301); Region: DUF4301; pfam14134
293826000581	Transposase IS200 like; Region: Y1_Tnp; cl00848
293826000582	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
293826000583	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
293826000584	putative transposase; Provisional; Region: PRK09857
293826000585	MarR family; Region: MarR_2; cl17246
293826000586	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
293826000587	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
293826000588	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826000589	Walker A motif; other site
293826000590	ATP binding site [chemical binding]; other site
293826000591	Walker B motif; other site
293826000592	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
293826000593	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
293826000594	DNA protecting protein DprA; Region: dprA; TIGR00732
293826000595	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
293826000596	Divergent AAA domain; Region: AAA_4; pfam04326
293826000597	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
293826000598	AAA domain; Region: AAA_30; pfam13604
293826000599	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
293826000600	AAA domain; Region: AAA_30; pfam13604
293826000601	AAA domain; Region: AAA_12; pfam13087
293826000602	Propionate catabolism activator; Region: PrpR_N; pfam06506
293826000603	PAS domain S-box; Region: sensory_box; TIGR00229
293826000604	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826000605	putative active site [active]
293826000606	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826000607	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
293826000608	Walker A motif; other site
293826000609	ATP binding site [chemical binding]; other site
293826000610	Walker B motif; other site
293826000611	arginine finger; other site
293826000612	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
293826000613	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
293826000614	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
293826000615	putative active site [active]
293826000616	metal binding site [ion binding]; metal-binding site
293826000617	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
293826000618	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
293826000619	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
293826000620	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
293826000621	inhibitor site; inhibition site
293826000622	active site
293826000623	dimer interface [polypeptide binding]; other site
293826000624	catalytic residue [active]
293826000625	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
293826000626	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
293826000627	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
293826000628	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
293826000629	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826000630	Walker A/P-loop; other site
293826000631	ATP binding site [chemical binding]; other site
293826000632	Q-loop/lid; other site
293826000633	ABC transporter signature motif; other site
293826000634	Walker B; other site
293826000635	D-loop; other site
293826000636	H-loop/switch region; other site
293826000637	ABC-2 type transporter; Region: ABC2_membrane; cl17235
293826000638	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
293826000639	AAA domain; Region: AAA_21; pfam13304
293826000640	Domain of unknown function (DUF368); Region: DUF368; cl00893
293826000641	Predicted membrane protein [Function unknown]; Region: COG4640
293826000642	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
293826000643	Double zinc ribbon; Region: DZR; pfam12773
293826000644	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
293826000645	Double zinc ribbon; Region: DZR; pfam12773
293826000646	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
293826000647	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
293826000648	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
293826000649	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
293826000650	DDE superfamily endonuclease; Region: DDE_5; cl17874
293826000651	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
293826000652	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
293826000653	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
293826000654	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826000655	active site
293826000656	phosphorylation site [posttranslational modification]
293826000657	intermolecular recognition site; other site
293826000658	dimerization interface [polypeptide binding]; other site
293826000659	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
293826000660	Cache domain; Region: Cache_1; pfam02743
293826000661	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826000662	dimerization interface [polypeptide binding]; other site
293826000663	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
293826000664	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826000665	dimer interface [polypeptide binding]; other site
293826000666	putative CheW interface [polypeptide binding]; other site
293826000667	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
293826000668	putative hexamer interface [polypeptide binding]; other site
293826000669	putative hexagonal pore; other site
293826000670	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
293826000671	G1 box; other site
293826000672	GTP/Mg2+ binding site [chemical binding]; other site
293826000673	G2 box; other site
293826000674	Switch I region; other site
293826000675	G3 box; other site
293826000676	Switch II region; other site
293826000677	G4 box; other site
293826000678	G5 box; other site
293826000679	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
293826000680	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826000681	active site
293826000682	phosphorylation site [posttranslational modification]
293826000683	intermolecular recognition site; other site
293826000684	dimerization interface [polypeptide binding]; other site
293826000685	ANTAR domain; Region: ANTAR; pfam03861
293826000686	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
293826000687	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
293826000688	PAS domain S-box; Region: sensory_box; TIGR00229
293826000689	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
293826000690	Histidine kinase; Region: HisKA_2; pfam07568
293826000691	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826000692	ATP binding site [chemical binding]; other site
293826000693	Mg2+ binding site [ion binding]; other site
293826000694	G-X-G motif; other site
293826000695	Ethanolamine utilisation protein EutA; Region: EutA; pfam06277
293826000696	Cell division protein FtsA; Region: FtsA; cl17206
293826000697	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
293826000698	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
293826000699	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
293826000700	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
293826000701	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
293826000702	putative hexamer interface [polypeptide binding]; other site
293826000703	putative hexagonal pore; other site
293826000704	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
293826000705	putative hexamer interface [polypeptide binding]; other site
293826000706	putative hexagonal pore; other site
293826000707	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
293826000708	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
293826000709	Hexamer interface [polypeptide binding]; other site
293826000710	Hexagonal pore residue; other site
293826000711	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
293826000712	putative catalytic cysteine [active]
293826000713	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
293826000714	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
293826000715	Hexamer interface [polypeptide binding]; other site
293826000716	Putative hexagonal pore residue; other site
293826000717	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
293826000718	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
293826000719	Propanediol utilisation protein PduL; Region: PduL; pfam06130
293826000720	Propanediol utilisation protein PduL; Region: PduL; pfam06130
293826000721	ethanolamine utilization protein EutJ; Provisional; Region: PRK15080
293826000722	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
293826000723	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
293826000724	Hexamer/Pentamer interface [polypeptide binding]; other site
293826000725	central pore; other site
293826000726	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
293826000727	SLBB domain; Region: SLBB; pfam10531
293826000728	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
293826000729	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
293826000730	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
293826000731	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
293826000732	putative hexamer interface [polypeptide binding]; other site
293826000733	putative hexagonal pore; other site
293826000734	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
293826000735	putative hexamer interface [polypeptide binding]; other site
293826000736	putative hexagonal pore; other site
293826000737	Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346
293826000738	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
293826000739	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
293826000740	putative active site [active]
293826000741	metal binding site [ion binding]; metal-binding site
293826000742	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
293826000743	myosin-cross-reactive antigen; Provisional; Region: PRK13977
293826000744	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
293826000745	CoA binding domain; Region: CoA_binding; cl17356
293826000746	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
293826000747	NAD(P) binding site [chemical binding]; other site
293826000748	homodimer interface [polypeptide binding]; other site
293826000749	substrate binding site [chemical binding]; other site
293826000750	active site
293826000751	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
293826000752	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
293826000753	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
293826000754	HlyD family secretion protein; Region: HlyD_3; pfam13437
293826000755	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
293826000756	Protein export membrane protein; Region: SecD_SecF; cl14618
293826000757	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
293826000758	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
293826000759	MreB/Mbl protein; Region: MreB_Mbl; pfam06723
293826000760	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
293826000761	nucleotide binding site [chemical binding]; other site
293826000762	putative NEF/HSP70 interaction site [polypeptide binding]; other site
293826000763	SBD interface [polypeptide binding]; other site
293826000764	TPR repeat; Region: TPR_11; pfam13414
293826000765	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826000766	binding surface
293826000767	TPR motif; other site
293826000768	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
293826000769	HSP70 interaction site [polypeptide binding]; other site
293826000770	Tetratricopeptide repeat; Region: TPR_16; pfam13432
293826000771	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826000772	Tetratricopeptide repeat; Region: TPR_16; pfam13432
293826000773	TPR motif; other site
293826000774	binding surface
293826000775	TPR repeat; Region: TPR_11; pfam13414
293826000776	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826000777	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826000778	active site
293826000779	phosphorylation site [posttranslational modification]
293826000780	intermolecular recognition site; other site
293826000781	dimerization interface [polypeptide binding]; other site
293826000782	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826000783	DNA binding site [nucleotide binding]
293826000784	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826000785	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826000786	dimerization interface [polypeptide binding]; other site
293826000787	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826000788	dimer interface [polypeptide binding]; other site
293826000789	phosphorylation site [posttranslational modification]
293826000790	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826000791	ATP binding site [chemical binding]; other site
293826000792	Mg2+ binding site [ion binding]; other site
293826000793	G-X-G motif; other site
293826000794	Minimal MMP-like domain found in Thermus thermophilus hypothetical protein TTHA0227 and similar proteins; Region: MMP_TTHA0227; cd12953
293826000795	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
293826000796	Interdomain contacts; other site
293826000797	Cytokine receptor motif; other site
293826000798	S-layer homology domain; Region: SLH; pfam00395
293826000799	S-layer homology domain; Region: SLH; pfam00395
293826000800	S-layer homology domain; Region: SLH; pfam00395
293826000801	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
293826000802	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
293826000803	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
293826000804	active site
293826000805	tetramer interface; other site
293826000806	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
293826000807	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
293826000808	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
293826000809	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
293826000810	ligand binding site [chemical binding]; other site
293826000811	S-layer homology domain; Region: SLH; pfam00395
293826000812	S-layer homology domain; Region: SLH; pfam00395
293826000813	S-layer homology domain; Region: SLH; pfam00395
293826000814	TPR repeat; Region: TPR_11; pfam13414
293826000815	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826000816	binding surface
293826000817	TPR motif; other site
293826000818	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
293826000819	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
293826000820	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
293826000821	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
293826000822	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
293826000823	NAD binding site [chemical binding]; other site
293826000824	homodimer interface [polypeptide binding]; other site
293826000825	active site
293826000826	substrate binding site [chemical binding]; other site
293826000827	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
293826000828	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
293826000829	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
293826000830	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
293826000831	Ligand binding site; other site
293826000832	Putative Catalytic site; other site
293826000833	DXD motif; other site
293826000834	Predicted membrane protein [Function unknown]; Region: COG2246
293826000835	GtrA-like protein; Region: GtrA; pfam04138
293826000836	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
293826000837	putative metal binding residues [ion binding]; other site
293826000838	signature motif; other site
293826000839	dimer interface [polypeptide binding]; other site
293826000840	active site
293826000841	polyP binding site; other site
293826000842	substrate binding site [chemical binding]; other site
293826000843	acceptor-phosphate pocket; other site
293826000844	CotH protein; Region: CotH; pfam08757
293826000845	Acyltransferase family; Region: Acyl_transf_3; pfam01757
293826000846	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
293826000847	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
293826000848	HlyD family secretion protein; Region: HlyD_3; pfam13437
293826000849	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
293826000850	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
293826000851	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
293826000852	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
293826000853	Na2 binding site [ion binding]; other site
293826000854	putative substrate binding site 1 [chemical binding]; other site
293826000855	Na binding site 1 [ion binding]; other site
293826000856	putative substrate binding site 2 [chemical binding]; other site
293826000857	Response regulator receiver domain; Region: Response_reg; pfam00072
293826000858	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826000859	active site
293826000860	phosphorylation site [posttranslational modification]
293826000861	intermolecular recognition site; other site
293826000862	dimerization interface [polypeptide binding]; other site
293826000863	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
293826000864	active site 2 [active]
293826000865	active site 1 [active]
293826000866	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
293826000867	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
293826000868	active site
293826000869	intersubunit interactions; other site
293826000870	catalytic residue [active]
293826000871	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
293826000872	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
293826000873	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
293826000874	putative active site [active]
293826000875	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
293826000876	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
293826000877	putative active site [active]
293826000878	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
293826000879	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
293826000880	transcription termination factor Rho; Provisional; Region: PRK12608
293826000881	RNA binding site [nucleotide binding]; other site
293826000882	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
293826000883	multimer interface [polypeptide binding]; other site
293826000884	Walker A motif; other site
293826000885	ATP binding site [chemical binding]; other site
293826000886	Walker B motif; other site
293826000887	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
293826000888	thymidine kinase; Provisional; Region: PRK04296
293826000889	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
293826000890	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
293826000891	DNA binding residues [nucleotide binding]
293826000892	dimer interface [polypeptide binding]; other site
293826000893	FMN-binding domain; Region: FMN_bind; pfam04205
293826000894	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
293826000895	L-aspartate oxidase; Provisional; Region: PRK06175
293826000896	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
293826000897	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
293826000898	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826000899	S-adenosylmethionine binding site [chemical binding]; other site
293826000900	peptide chain release factor 1; Validated; Region: prfA; PRK00591
293826000901	This domain is found in peptide chain release factors; Region: PCRF; smart00937
293826000902	RF-1 domain; Region: RF-1; pfam00472
293826000903	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
293826000904	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
293826000905	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
293826000906	phosphopeptide binding site; other site
293826000907	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
293826000908	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
293826000909	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
293826000910	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
293826000911	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
293826000912	Low molecular weight phosphatase family; Region: LMWPc; cd00115
293826000913	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
293826000914	active site
293826000915	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
293826000916	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
293826000917	active site
293826000918	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
293826000919	catalytic motif [active]
293826000920	Zn binding site [ion binding]; other site
293826000921	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
293826000922	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
293826000923	Mg++ binding site [ion binding]; other site
293826000924	putative catalytic motif [active]
293826000925	substrate binding site [chemical binding]; other site
293826000926	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
293826000927	Na2 binding site [ion binding]; other site
293826000928	putative substrate binding site 1 [chemical binding]; other site
293826000929	Na binding site 1 [ion binding]; other site
293826000930	putative substrate binding site 2 [chemical binding]; other site
293826000931	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
293826000932	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
293826000933	active site
293826000934	homodimer interface [polypeptide binding]; other site
293826000935	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
293826000936	ATP synthase I chain; Region: ATP_synt_I; pfam03899
293826000937	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
293826000938	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
293826000939	ATP synthase subunit C; Region: ATP-synt_C; cl00466
293826000940	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
293826000941	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
293826000942	F0F1 ATP synthase subunit B; Provisional; Region: PRK13461
293826000943	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
293826000944	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
293826000945	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
293826000946	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
293826000947	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
293826000948	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
293826000949	beta subunit interaction interface [polypeptide binding]; other site
293826000950	Walker A motif; other site
293826000951	ATP binding site [chemical binding]; other site
293826000952	Walker B motif; other site
293826000953	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
293826000954	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
293826000955	core domain interface [polypeptide binding]; other site
293826000956	delta subunit interface [polypeptide binding]; other site
293826000957	epsilon subunit interface [polypeptide binding]; other site
293826000958	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
293826000959	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
293826000960	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
293826000961	alpha subunit interaction interface [polypeptide binding]; other site
293826000962	Walker A motif; other site
293826000963	ATP binding site [chemical binding]; other site
293826000964	Walker B motif; other site
293826000965	inhibitor binding site; inhibition site
293826000966	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
293826000967	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
293826000968	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
293826000969	gamma subunit interface [polypeptide binding]; other site
293826000970	epsilon subunit interface [polypeptide binding]; other site
293826000971	LBP interface [polypeptide binding]; other site
293826000972	N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846
293826000973	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
293826000974	Protein of unknown function (DUF1779); Region: DUF1779; pfam08680
293826000975	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
293826000976	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
293826000977	hinge; other site
293826000978	active site
293826000979	stage II sporulation protein D; Region: spore_II_D; TIGR02870
293826000980	Stage II sporulation protein; Region: SpoIID; pfam08486
293826000981	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
293826000982	Peptidase family M23; Region: Peptidase_M23; pfam01551
293826000983	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
293826000984	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
293826000985	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
293826000986	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
293826000987	HlyD family secretion protein; Region: HlyD_3; pfam13437
293826000988	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
293826000989	Stage III sporulation protein D; Region: SpoIIID; pfam12116
293826000990	rod shape-determining protein Mbl; Provisional; Region: PRK13928
293826000991	MreB and similar proteins; Region: MreB_like; cd10225
293826000992	nucleotide binding site [chemical binding]; other site
293826000993	Mg binding site [ion binding]; other site
293826000994	putative protofilament interaction site [polypeptide binding]; other site
293826000995	RodZ interaction site [polypeptide binding]; other site
293826000996	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
293826000997	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
293826000998	Walker A/P-loop; other site
293826000999	ATP binding site [chemical binding]; other site
293826001000	Q-loop/lid; other site
293826001001	ABC transporter signature motif; other site
293826001002	Walker B; other site
293826001003	D-loop; other site
293826001004	H-loop/switch region; other site
293826001005	S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361
293826001006	S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361
293826001007	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
293826001008	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
293826001009	FtsX-like permease family; Region: FtsX; pfam02687
293826001010	Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749
293826001011	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
293826001012	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
293826001013	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
293826001014	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
293826001015	Rod binding protein; Region: Rod-binding; cl01626
293826001016	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
293826001017	Transposase IS200 like; Region: Y1_Tnp; cl00848
293826001018	Domain of unknown function (DUF368); Region: DUF368; pfam04018
293826001019	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
293826001020	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
293826001021	active site
293826001022	tetramer interface; other site
293826001023	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
293826001024	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
293826001025	Transcriptional regulators [Transcription]; Region: FadR; COG2186
293826001026	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826001027	DNA-binding site [nucleotide binding]; DNA binding site
293826001028	FCD domain; Region: FCD; pfam07729
293826001029	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826001030	non-specific DNA binding site [nucleotide binding]; other site
293826001031	salt bridge; other site
293826001032	sequence-specific DNA binding site [nucleotide binding]; other site
293826001033	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
293826001034	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826001035	non-specific DNA binding site [nucleotide binding]; other site
293826001036	salt bridge; other site
293826001037	sequence-specific DNA binding site [nucleotide binding]; other site
293826001038	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
293826001039	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
293826001040	Integrase core domain; Region: rve; pfam00665
293826001041	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
293826001042	AAA domain; Region: AAA_22; pfam13401
293826001043	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
293826001044	Protein of unknown function (DUF1018); Region: DUF1018; cl01815
293826001045	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
293826001046	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826001047	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826001048	DNA binding residues [nucleotide binding]
293826001049	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
293826001050	3D domain; Region: 3D; cl01439
293826001051	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
293826001052	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
293826001053	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
293826001054	active site
293826001055	Bacterial SH3 domain; Region: SH3_3; cl17532
293826001056	Mor transcription activator family; Region: Mor; cl02360
293826001057	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
293826001058	transcription termination/antitermination factor NusG; Region: nusG; TIGR00922
293826001059	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000
293826001060	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
293826001061	heterodimer interface [polypeptide binding]; other site
293826001062	homodimer interface [polypeptide binding]; other site
293826001063	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
293826001064	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
293826001065	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
293826001066	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
293826001067	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
293826001068	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566
293826001069	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
293826001070	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834
293826001071	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
293826001072	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
293826001073	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
293826001074	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
293826001075	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
293826001076	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
293826001077	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900
293826001078	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
293826001079	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
293826001080	active site
293826001081	DNA binding site [nucleotide binding]
293826001082	Int/Topo IB signature motif; other site
293826001083	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
293826001084	Electron transfer flavoprotein domain; Region: ETF; pfam01012
293826001085	Ligand binding site [chemical binding]; other site
293826001086	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
293826001087	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
293826001088	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
293826001089	Uncharacterized membrane protein [Function unknown]; Region: COG3949
293826001090	FAD binding domain; Region: FAD_binding_4; pfam01565
293826001091	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
293826001092	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
293826001093	Transposase [DNA replication, recombination, and repair]; Region: COG5421
293826001094	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
293826001095	HSP70 interaction site [polypeptide binding]; other site
293826001096	Predicted integral membrane protein [Function unknown]; Region: COG5652
293826001097	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
293826001098	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
293826001099	catalytic triad [active]
293826001100	Transcriptional regulators [Transcription]; Region: PurR; COG1609
293826001101	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
293826001102	DNA binding site [nucleotide binding]
293826001103	domain linker motif; other site
293826001104	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
293826001105	dimerization interface [polypeptide binding]; other site
293826001106	ligand binding site [chemical binding]; other site
293826001107	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
293826001108	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
293826001109	ligand binding site [chemical binding]; other site
293826001110	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
293826001111	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
293826001112	Walker A/P-loop; other site
293826001113	ATP binding site [chemical binding]; other site
293826001114	Q-loop/lid; other site
293826001115	ABC transporter signature motif; other site
293826001116	Walker B; other site
293826001117	D-loop; other site
293826001118	H-loop/switch region; other site
293826001119	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
293826001120	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
293826001121	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
293826001122	TM-ABC transporter signature motif; other site
293826001123	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
293826001124	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
293826001125	Metal-binding active site; metal-binding site
293826001126	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
293826001127	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
293826001128	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
293826001129	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
293826001130	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
293826001131	Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690
293826001132	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
293826001133	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
293826001134	putative dimer interface [polypeptide binding]; other site
293826001135	active site pocket [active]
293826001136	putative cataytic base [active]
293826001137	xanthine permease; Region: pbuX; TIGR03173
293826001138	Sulfate transporter family; Region: Sulfate_transp; pfam00916
293826001139	Transposase domain (DUF772); Region: DUF772; pfam05598
293826001140	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826001141	dimerization interface [polypeptide binding]; other site
293826001142	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
293826001143	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826001144	dimer interface [polypeptide binding]; other site
293826001145	putative CheW interface [polypeptide binding]; other site
293826001146	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
293826001147	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
293826001148	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
293826001149	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
293826001150	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
293826001151	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
293826001152	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
293826001153	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
293826001154	Domain of unknown function (DUF3870); Region: DUF3870; pfam12986
293826001155	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
293826001156	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
293826001157	active site
293826001158	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
293826001159	dimer interface [polypeptide binding]; other site
293826001160	catalytic triad [active]
293826001161	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
293826001162	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
293826001163	active site
293826001164	dimer interface [polypeptide binding]; other site
293826001165	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
293826001166	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
293826001167	DNA binding residues [nucleotide binding]
293826001168	dimer interface [polypeptide binding]; other site
293826001169	FMN-binding domain; Region: FMN_bind; cl01081
293826001170	tricarballylate dehydrogenase; Validated; Region: PRK08274
293826001171	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
293826001172	AIR carboxylase; Region: AIRC; smart01001
293826001173	Protein of unknown function DUF111; Region: DUF111; pfam01969
293826001174	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
293826001175	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
293826001176	Ligand Binding Site [chemical binding]; other site
293826001177	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
293826001178	putative metal binding site [ion binding]; other site
293826001179	putative dimer interface [polypeptide binding]; other site
293826001180	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
293826001181	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
293826001182	CoA-ligase; Region: Ligase_CoA; pfam00549
293826001183	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
293826001184	CoA binding domain; Region: CoA_binding; smart00881
293826001185	CoA-ligase; Region: Ligase_CoA; pfam00549
293826001186	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
293826001187	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
293826001188	ligand binding site [chemical binding]; other site
293826001189	Histidine kinase; Region: HisKA_3; pfam07730
293826001190	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826001191	ATP binding site [chemical binding]; other site
293826001192	Mg2+ binding site [ion binding]; other site
293826001193	G-X-G motif; other site
293826001194	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
293826001195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826001196	active site
293826001197	phosphorylation site [posttranslational modification]
293826001198	intermolecular recognition site; other site
293826001199	dimerization interface [polypeptide binding]; other site
293826001200	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
293826001201	DNA binding residues [nucleotide binding]
293826001202	dimerization interface [polypeptide binding]; other site
293826001203	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
293826001204	Catalytic site [active]
293826001205	S-layer homology domain; Region: SLH; pfam00395
293826001206	S-layer homology domain; Region: SLH; pfam00395
293826001207	S-layer homology domain; Region: SLH; pfam00395
293826001208	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140
293826001209	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
293826001210	Transcriptional regulator [Transcription]; Region: IclR; COG1414
293826001211	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
293826001212	Bacterial transcriptional regulator; Region: IclR; pfam01614
293826001213	fructuronate transporter; Provisional; Region: PRK10034; cl15264
293826001214	GntP family permease; Region: GntP_permease; pfam02447
293826001215	Dehydratase family; Region: ILVD_EDD; pfam00920
293826001216	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
293826001217	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
293826001218	aspartate aminotransferase; Provisional; Region: PRK05764
293826001219	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
293826001220	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826001221	homodimer interface [polypeptide binding]; other site
293826001222	catalytic residue [active]
293826001223	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
293826001224	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
293826001225	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
293826001226	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
293826001227	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826001228	FeS/SAM binding site; other site
293826001229	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
293826001230	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
293826001231	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
293826001232	catalytic residue [active]
293826001233	4-aminobutyrate aminotransferase; Provisional; Region: PRK08360
293826001234	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
293826001235	inhibitor-cofactor binding pocket; inhibition site
293826001236	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826001237	catalytic residue [active]
293826001238	hydroperoxidase II; Provisional; Region: katE; PRK11249
293826001239	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
293826001240	tetramer interface [polypeptide binding]; other site
293826001241	heme binding pocket [chemical binding]; other site
293826001242	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
293826001243	domain interactions; other site
293826001244	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
293826001245	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
293826001246	Spore germination protein; Region: Spore_permease; cl17796
293826001247	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
293826001248	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
293826001249	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
293826001250	substrate binding pocket [chemical binding]; other site
293826001251	membrane-bound complex binding site; other site
293826001252	hinge residues; other site
293826001253	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
293826001254	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
293826001255	Walker A/P-loop; other site
293826001256	ATP binding site [chemical binding]; other site
293826001257	Q-loop/lid; other site
293826001258	ABC transporter signature motif; other site
293826001259	Walker B; other site
293826001260	D-loop; other site
293826001261	H-loop/switch region; other site
293826001262	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
293826001263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826001264	dimer interface [polypeptide binding]; other site
293826001265	conserved gate region; other site
293826001266	putative PBP binding loops; other site
293826001267	ABC-ATPase subunit interface; other site
293826001268	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
293826001269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
293826001270	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
293826001271	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
293826001272	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
293826001273	Walker A/P-loop; other site
293826001274	ATP binding site [chemical binding]; other site
293826001275	Q-loop/lid; other site
293826001276	ABC transporter signature motif; other site
293826001277	Walker B; other site
293826001278	D-loop; other site
293826001279	H-loop/switch region; other site
293826001280	heat shock protein 90; Provisional; Region: PRK05218
293826001281	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826001282	ATP binding site [chemical binding]; other site
293826001283	Mg2+ binding site [ion binding]; other site
293826001284	G-X-G motif; other site
293826001285	cobalt transport protein CbiM; Validated; Region: PRK06265
293826001286	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
293826001287	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
293826001288	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13647
293826001289	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
293826001290	Walker A/P-loop; other site
293826001291	ATP binding site [chemical binding]; other site
293826001292	Q-loop/lid; other site
293826001293	ABC transporter signature motif; other site
293826001294	Walker B; other site
293826001295	D-loop; other site
293826001296	H-loop/switch region; other site
293826001297	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
293826001298	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826001299	Zn2+ binding site [ion binding]; other site
293826001300	Mg2+ binding site [ion binding]; other site
293826001301	Uncharacterized conserved protein [Function unknown]; Region: COG0327
293826001302	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
293826001303	Predicted membrane protein [Function unknown]; Region: COG4758
293826001304	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
293826001305	Peptidase M15; Region: Peptidase_M15_3; cl01194
293826001306	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
293826001307	catalytic core [active]
293826001308	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
293826001309	YCII-related domain; Region: YCII; cl00999
293826001310	PrcB C-terminal; Region: PrcB_C; pfam14343
293826001311	Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648
293826001312	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
293826001313	Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
293826001314	Uncharacterized membrane protein [Function unknown]; Region: COG3949
293826001315	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
293826001316	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
293826001317	tetramer interface [polypeptide binding]; other site
293826001318	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826001319	catalytic residue [active]
293826001320	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826001321	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
293826001322	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826001323	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
293826001324	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826001325	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826001326	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
293826001327	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
293826001328	active site
293826001329	metal binding site [ion binding]; metal-binding site
293826001330	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
293826001331	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826001332	YibE/F-like protein; Region: YibE_F; pfam07907
293826001333	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
293826001334	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
293826001335	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826001336	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826001337	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
293826001338	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
293826001339	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826001340	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826001341	active site
293826001342	phosphorylation site [posttranslational modification]
293826001343	intermolecular recognition site; other site
293826001344	dimerization interface [polypeptide binding]; other site
293826001345	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826001346	DNA binding site [nucleotide binding]
293826001347	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826001348	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826001349	dimerization interface [polypeptide binding]; other site
293826001350	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826001351	dimer interface [polypeptide binding]; other site
293826001352	phosphorylation site [posttranslational modification]
293826001353	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826001354	ATP binding site [chemical binding]; other site
293826001355	Mg2+ binding site [ion binding]; other site
293826001356	G-X-G motif; other site
293826001357	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
293826001358	Zn binding site [ion binding]; other site
293826001359	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
293826001360	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
293826001361	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
293826001362	DctM-like transporters; Region: DctM; pfam06808
293826001363	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
293826001364	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826001365	DNA-binding site [nucleotide binding]; DNA binding site
293826001366	Transcriptional regulators [Transcription]; Region: FadR; COG2186
293826001367	FCD domain; Region: FCD; pfam07729
293826001368	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
293826001369	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
293826001370	putative NAD(P) binding site [chemical binding]; other site
293826001371	catalytic Zn binding site [ion binding]; other site
293826001372	structural Zn binding site [ion binding]; other site
293826001373	altronate oxidoreductase; Provisional; Region: PRK03643
293826001374	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
293826001375	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
293826001376	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
293826001377	galactarate dehydratase; Region: galactar-dH20; TIGR03248
293826001378	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
293826001379	glycerol kinase; Provisional; Region: glpK; PRK00047
293826001380	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
293826001381	N- and C-terminal domain interface [polypeptide binding]; other site
293826001382	active site
293826001383	MgATP binding site [chemical binding]; other site
293826001384	catalytic site [active]
293826001385	metal binding site [ion binding]; metal-binding site
293826001386	glycerol binding site [chemical binding]; other site
293826001387	homotetramer interface [polypeptide binding]; other site
293826001388	homodimer interface [polypeptide binding]; other site
293826001389	FBP binding site [chemical binding]; other site
293826001390	protein IIAGlc interface [polypeptide binding]; other site
293826001391	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
293826001392	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
293826001393	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
293826001394	DctM-like transporters; Region: DctM; pfam06808
293826001395	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
293826001396	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
293826001397	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
293826001398	active site
293826001399	catalytic site [active]
293826001400	metal binding site [ion binding]; metal-binding site
293826001401	dimer interface [polypeptide binding]; other site
293826001402	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
293826001403	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
293826001404	MgtC family; Region: MgtC; pfam02308
293826001405	Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
293826001406	hypothetical protein; Provisional; Region: PRK04435
293826001407	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
293826001408	homoserine dehydrogenase; Provisional; Region: PRK06349
293826001409	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
293826001410	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
293826001411	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
293826001412	threonine synthase; Reviewed; Region: PRK06721
293826001413	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
293826001414	homodimer interface [polypeptide binding]; other site
293826001415	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826001416	catalytic residue [active]
293826001417	homoserine kinase; Provisional; Region: PRK01212
293826001418	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
293826001419	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
293826001420	dimerization domain swap beta strand [polypeptide binding]; other site
293826001421	regulatory protein interface [polypeptide binding]; other site
293826001422	active site
293826001423	regulatory phosphorylation site [posttranslational modification]; other site
293826001424	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
293826001425	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
293826001426	dimer interface [polypeptide binding]; other site
293826001427	motif 1; other site
293826001428	active site
293826001429	motif 2; other site
293826001430	motif 3; other site
293826001431	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
293826001432	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
293826001433	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
293826001434	histidinol dehydrogenase; Region: hisD; TIGR00069
293826001435	NAD binding site [chemical binding]; other site
293826001436	dimerization interface [polypeptide binding]; other site
293826001437	product binding site; other site
293826001438	substrate binding site [chemical binding]; other site
293826001439	zinc binding site [ion binding]; other site
293826001440	catalytic residues [active]
293826001441	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
293826001442	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
293826001443	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826001444	homodimer interface [polypeptide binding]; other site
293826001445	catalytic residue [active]
293826001446	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
293826001447	putative active site pocket [active]
293826001448	4-fold oligomerization interface [polypeptide binding]; other site
293826001449	metal binding residues [ion binding]; metal-binding site
293826001450	3-fold/trimer interface [polypeptide binding]; other site
293826001451	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
293826001452	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
293826001453	putative active site [active]
293826001454	oxyanion strand; other site
293826001455	catalytic triad [active]
293826001456	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
293826001457	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
293826001458	catalytic residues [active]
293826001459	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
293826001460	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
293826001461	substrate binding site [chemical binding]; other site
293826001462	glutamase interaction surface [polypeptide binding]; other site
293826001463	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
293826001464	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
293826001465	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
293826001466	metal binding site [ion binding]; metal-binding site
293826001467	pyruvate carboxylase; Reviewed; Region: PRK12999
293826001468	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
293826001469	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
293826001470	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
293826001471	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
293826001472	active site
293826001473	catalytic residues [active]
293826001474	metal binding site [ion binding]; metal-binding site
293826001475	homodimer binding site [polypeptide binding]; other site
293826001476	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
293826001477	carboxyltransferase (CT) interaction site; other site
293826001478	biotinylation site [posttranslational modification]; other site
293826001479	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
293826001480	Na2 binding site [ion binding]; other site
293826001481	putative substrate binding site 1 [chemical binding]; other site
293826001482	Na binding site 1 [ion binding]; other site
293826001483	putative substrate binding site 2 [chemical binding]; other site
293826001484	HAMP domain; Region: HAMP; pfam00672
293826001485	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
293826001486	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826001487	dimer interface [polypeptide binding]; other site
293826001488	putative CheW interface [polypeptide binding]; other site
293826001489	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
293826001490	4Fe-4S binding domain; Region: Fer4; pfam00037
293826001491	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
293826001492	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
293826001493	dimer interface [polypeptide binding]; other site
293826001494	active site
293826001495	glycine loop; other site
293826001496	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
293826001497	active site
293826001498	putative catalytic site [active]
293826001499	DNA binding site [nucleotide binding]
293826001500	putative phosphate binding site [ion binding]; other site
293826001501	metal binding site A [ion binding]; metal-binding site
293826001502	AP binding site [nucleotide binding]; other site
293826001503	metal binding site B [ion binding]; metal-binding site
293826001504	Transcriptional regulators [Transcription]; Region: PurR; COG1609
293826001505	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
293826001506	DNA binding site [nucleotide binding]
293826001507	domain linker motif; other site
293826001508	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
293826001509	dimerization interface [polypeptide binding]; other site
293826001510	ligand binding site [chemical binding]; other site
293826001511	sodium binding site [ion binding]; other site
293826001512	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
293826001513	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826001514	Walker A/P-loop; other site
293826001515	ATP binding site [chemical binding]; other site
293826001516	Q-loop/lid; other site
293826001517	ABC transporter signature motif; other site
293826001518	Walker B; other site
293826001519	D-loop; other site
293826001520	H-loop/switch region; other site
293826001521	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
293826001522	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
293826001523	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
293826001524	TM-ABC transporter signature motif; other site
293826001525	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
293826001526	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
293826001527	ligand binding site [chemical binding]; other site
293826001528	L-idonate 5-dehydrogenase; Region: PLN02702
293826001529	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
293826001530	inhibitor binding site; inhibition site
293826001531	catalytic Zn binding site [ion binding]; other site
293826001532	structural Zn binding site [ion binding]; other site
293826001533	NADP binding site [chemical binding]; other site
293826001534	tetramer interface [polypeptide binding]; other site
293826001535	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
293826001536	N- and C-terminal domain interface [polypeptide binding]; other site
293826001537	D-xylulose kinase; Region: XylB; TIGR01312
293826001538	active site
293826001539	MgATP binding site [chemical binding]; other site
293826001540	catalytic site [active]
293826001541	metal binding site [ion binding]; metal-binding site
293826001542	xylulose binding site [chemical binding]; other site
293826001543	homodimer interface [polypeptide binding]; other site
293826001544	D-cysteine desulfhydrase; Validated; Region: PRK03910
293826001545	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
293826001546	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
293826001547	catalytic residue [active]
293826001548	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
293826001549	putative FMN binding site [chemical binding]; other site
293826001550	SWIM zinc finger; Region: SWIM; pfam04434
293826001551	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
293826001552	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
293826001553	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
293826001554	ATP binding site [chemical binding]; other site
293826001555	putative Mg++ binding site [ion binding]; other site
293826001556	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
293826001557	nucleotide binding region [chemical binding]; other site
293826001558	ATP-binding site [chemical binding]; other site
293826001559	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
293826001560	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
293826001561	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
293826001562	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
293826001563	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
293826001564	Walker A/P-loop; other site
293826001565	ATP binding site [chemical binding]; other site
293826001566	Q-loop/lid; other site
293826001567	ABC transporter signature motif; other site
293826001568	Walker B; other site
293826001569	D-loop; other site
293826001570	H-loop/switch region; other site
293826001571	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
293826001572	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
293826001573	FtsX-like permease family; Region: FtsX; pfam02687
293826001574	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
293826001575	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
293826001576	FtsX-like permease family; Region: FtsX; pfam02687
293826001577	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
293826001578	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
293826001579	HlyD family secretion protein; Region: HlyD_3; pfam13437
293826001580	B12 binding domain; Region: B12-binding; pfam02310
293826001581	B12 binding site [chemical binding]; other site
293826001582	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
293826001583	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826001584	FeS/SAM binding site; other site
293826001585	NMT1/THI5 like; Region: NMT1; pfam09084
293826001586	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826001587	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
293826001588	dimer interface [polypeptide binding]; other site
293826001589	phosphorylation site [posttranslational modification]
293826001590	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826001591	ATP binding site [chemical binding]; other site
293826001592	Mg2+ binding site [ion binding]; other site
293826001593	G-X-G motif; other site
293826001594	Response regulator receiver domain; Region: Response_reg; pfam00072
293826001595	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826001596	active site
293826001597	phosphorylation site [posttranslational modification]
293826001598	intermolecular recognition site; other site
293826001599	dimerization interface [polypeptide binding]; other site
293826001600	xanthine permease; Region: pbuX; TIGR03173
293826001601	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
293826001602	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
293826001603	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
293826001604	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
293826001605	catalytic loop [active]
293826001606	iron binding site [ion binding]; other site
293826001607	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
293826001608	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
293826001609	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
293826001610	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
293826001611	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
293826001612	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
293826001613	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
293826001614	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
293826001615	FliG C-terminal domain; Region: FliG_C; pfam01706
293826001616	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
293826001617	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
293826001618	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
293826001619	flagellar motor switch protein FliN; Region: fliN; TIGR02480
293826001620	Response regulator receiver domain; Region: Response_reg; pfam00072
293826001621	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826001622	active site
293826001623	phosphorylation site [posttranslational modification]
293826001624	intermolecular recognition site; other site
293826001625	dimerization interface [polypeptide binding]; other site
293826001626	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
293826001627	FHIPEP family; Region: FHIPEP; pfam00771
293826001628	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
293826001629	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
293826001630	Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782
293826001631	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
293826001632	DNA binding residues [nucleotide binding]
293826001633	dimer interface [polypeptide binding]; other site
293826001634	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
293826001635	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
293826001636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826001637	active site
293826001638	phosphorylation site [posttranslational modification]
293826001639	intermolecular recognition site; other site
293826001640	dimerization interface [polypeptide binding]; other site
293826001641	LytTr DNA-binding domain; Region: LytTR; smart00850
293826001642	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826001643	ATP binding site [chemical binding]; other site
293826001644	Mg2+ binding site [ion binding]; other site
293826001645	G-X-G motif; other site
293826001646	Accessory gene regulator B; Region: AgrB; pfam04647
293826001647	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
293826001648	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
293826001649	putative active site [active]
293826001650	putative NTP binding site [chemical binding]; other site
293826001651	putative nucleic acid binding site [nucleotide binding]; other site
293826001652	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
293826001653	Transposase [DNA replication, recombination, and repair]; Region: COG5421
293826001654	Staphylococcal AgrD protein; Region: AgrD; cl05477
293826001655	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826001656	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826001657	ATP binding site [chemical binding]; other site
293826001658	Mg2+ binding site [ion binding]; other site
293826001659	G-X-G motif; other site
293826001660	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
293826001661	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
293826001662	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
293826001663	putative dimer interface [polypeptide binding]; other site
293826001664	[2Fe-2S] cluster binding site [ion binding]; other site
293826001665	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
293826001666	dimer interface [polypeptide binding]; other site
293826001667	[2Fe-2S] cluster binding site [ion binding]; other site
293826001668	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
293826001669	dimer interface [polypeptide binding]; other site
293826001670	[2Fe-2S] cluster binding site [ion binding]; other site
293826001671	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
293826001672	SLBB domain; Region: SLBB; pfam10531
293826001673	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
293826001674	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
293826001675	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
293826001676	catalytic loop [active]
293826001677	iron binding site [ion binding]; other site
293826001678	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
293826001679	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
293826001680	4Fe-4S binding domain; Region: Fer4; pfam00037
293826001681	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
293826001682	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
293826001683	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
293826001684	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
293826001685	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
293826001686	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
293826001687	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
293826001688	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
293826001689	prephenate dehydrogenase; Validated; Region: PRK06545
293826001690	prephenate dehydrogenase; Validated; Region: PRK08507
293826001691	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
293826001692	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
293826001693	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
293826001694	hinge; other site
293826001695	active site
293826001696	prephenate dehydratase; Provisional; Region: PRK11898
293826001697	Prephenate dehydratase; Region: PDT; pfam00800
293826001698	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
293826001699	putative L-Phe binding site [chemical binding]; other site
293826001700	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
293826001701	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
293826001702	Tetramer interface [polypeptide binding]; other site
293826001703	active site
293826001704	FMN-binding site [chemical binding]; other site
293826001705	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
293826001706	active site
293826001707	dimer interface [polypeptide binding]; other site
293826001708	metal binding site [ion binding]; metal-binding site
293826001709	monofunctional chorismate mutase, gram positive-type, clade 2; Region: CM_mono_grmpos; TIGR01805
293826001710	shikimate kinase; Reviewed; Region: aroK; PRK00131
293826001711	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
293826001712	ADP binding site [chemical binding]; other site
293826001713	magnesium binding site [ion binding]; other site
293826001714	putative shikimate binding site; other site
293826001715	argininosuccinate lyase; Provisional; Region: PRK00855
293826001716	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
293826001717	active sites [active]
293826001718	tetramer interface [polypeptide binding]; other site
293826001719	argininosuccinate synthase; Provisional; Region: PRK13820
293826001720	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
293826001721	ANP binding site [chemical binding]; other site
293826001722	Substrate Binding Site II [chemical binding]; other site
293826001723	Substrate Binding Site I [chemical binding]; other site
293826001724	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
293826001725	NlpC/P60 family; Region: NLPC_P60; cl17555
293826001726	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826001727	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826001728	dimerization interface [polypeptide binding]; other site
293826001729	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826001730	dimer interface [polypeptide binding]; other site
293826001731	phosphorylation site [posttranslational modification]
293826001732	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826001733	ATP binding site [chemical binding]; other site
293826001734	Mg2+ binding site [ion binding]; other site
293826001735	G-X-G motif; other site
293826001736	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826001737	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826001738	active site
293826001739	phosphorylation site [posttranslational modification]
293826001740	intermolecular recognition site; other site
293826001741	dimerization interface [polypeptide binding]; other site
293826001742	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826001743	DNA binding site [nucleotide binding]
293826001744	FOG: CBS domain [General function prediction only]; Region: COG0517
293826001745	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
293826001746	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826001747	dimerization interface [polypeptide binding]; other site
293826001748	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
293826001749	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826001750	dimer interface [polypeptide binding]; other site
293826001751	putative CheW interface [polypeptide binding]; other site
293826001752	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
293826001753	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
293826001754	metal binding site [ion binding]; metal-binding site
293826001755	dimer interface [polypeptide binding]; other site
293826001756	Predicted membrane protein [Function unknown]; Region: COG1288
293826001757	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
293826001758	spore photoproduct lyase; Region: photo_TT_lyase; TIGR04070
293826001759	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
293826001760	FOG: CBS domain [General function prediction only]; Region: COG0517
293826001761	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_13; cd04626
293826001762	PAS domain; Region: PAS; smart00091
293826001763	PAS fold; Region: PAS_4; pfam08448
293826001764	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
293826001765	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826001766	Walker A motif; other site
293826001767	ATP binding site [chemical binding]; other site
293826001768	Walker B motif; other site
293826001769	arginine finger; other site
293826001770	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
293826001771	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
293826001772	Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338
293826001773	glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917
293826001774	glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917
293826001775	Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338
293826001776	Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338
293826001777	proline racemase; Provisional; Region: PRK13969
293826001778	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
293826001779	Predicted permeases [General function prediction only]; Region: COG0730
293826001780	gamma-glutamyl kinase; Provisional; Region: PRK05429
293826001781	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
293826001782	nucleotide binding site [chemical binding]; other site
293826001783	homotetrameric interface [polypeptide binding]; other site
293826001784	putative phosphate binding site [ion binding]; other site
293826001785	putative allosteric binding site; other site
293826001786	prolyl-tRNA synthetase; Provisional; Region: PRK09194
293826001787	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
293826001788	dimer interface [polypeptide binding]; other site
293826001789	motif 1; other site
293826001790	active site
293826001791	motif 2; other site
293826001792	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
293826001793	putative deacylase active site [active]
293826001794	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
293826001795	active site
293826001796	motif 3; other site
293826001797	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
293826001798	anticodon binding site; other site
293826001799	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
293826001800	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826001801	dimer interface [polypeptide binding]; other site
293826001802	putative CheW interface [polypeptide binding]; other site
293826001803	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
293826001804	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
293826001805	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
293826001806	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
293826001807	glyoxylate reductase; Reviewed; Region: PRK13243
293826001808	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
293826001809	dimerization interface [polypeptide binding]; other site
293826001810	ligand binding site [chemical binding]; other site
293826001811	NADP binding site [chemical binding]; other site
293826001812	catalytic site [active]
293826001813	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
293826001814	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
293826001815	MOFRL family; Region: MOFRL; pfam05161
293826001816	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
293826001817	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
293826001818	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
293826001819	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
293826001820	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
293826001821	putative NAD(P) binding site [chemical binding]; other site
293826001822	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
293826001823	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
293826001824	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
293826001825	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
293826001826	catalytic loop [active]
293826001827	iron binding site [ion binding]; other site
293826001828	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
293826001829	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
293826001830	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
293826001831	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
293826001832	uracil transporter; Provisional; Region: PRK10720
293826001833	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
293826001834	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
293826001835	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
293826001836	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
293826001837	CoA binding domain; Region: CoA_binding; pfam02629
293826001838	CoA-ligase; Region: Ligase_CoA; pfam00549
293826001839	Class I aldolases; Region: Aldolase_Class_I; cl17187
293826001840	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
293826001841	Putative cyclase; Region: Cyclase; pfam04199
293826001842	Predicted amidohydrolase [General function prediction only]; Region: COG0388
293826001843	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
293826001844	active site
293826001845	catalytic triad [active]
293826001846	dimer interface [polypeptide binding]; other site
293826001847	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
293826001848	CoA-transferase family III; Region: CoA_transf_3; pfam02515
293826001849	Progressive ankylosis protein (ANKH); Region: ANKH; pfam07260
293826001850	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
293826001851	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
293826001852	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
293826001853	transmembrane helices; other site
293826001854	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
293826001855	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
293826001856	inhibitor-cofactor binding pocket; inhibition site
293826001857	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826001858	catalytic residue [active]
293826001859	amino acid transporter; Region: 2A0306; TIGR00909
293826001860	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
293826001861	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790
293826001862	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
293826001863	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
293826001864	PAS fold; Region: PAS_4; pfam08448
293826001865	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
293826001866	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826001867	Walker A motif; other site
293826001868	ATP binding site [chemical binding]; other site
293826001869	Walker B motif; other site
293826001870	arginine finger; other site
293826001871	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
293826001872	Domain of unknown function (DUF368); Region: DUF368; pfam04018
293826001873	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
293826001874	putative kinase; Provisional; Region: PRK09954
293826001875	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
293826001876	substrate binding site [chemical binding]; other site
293826001877	ATP binding site [chemical binding]; other site
293826001878	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
293826001879	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
293826001880	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826001881	ATP binding site [chemical binding]; other site
293826001882	Mg2+ binding site [ion binding]; other site
293826001883	G-X-G motif; other site
293826001884	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
293826001885	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
293826001886	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826001887	Zn2+ binding site [ion binding]; other site
293826001888	Mg2+ binding site [ion binding]; other site
293826001889	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
293826001890	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
293826001891	active site
293826001892	substrate binding site [chemical binding]; other site
293826001893	metal binding site [ion binding]; metal-binding site
293826001894	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826001895	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826001896	active site
293826001897	phosphorylation site [posttranslational modification]
293826001898	intermolecular recognition site; other site
293826001899	dimerization interface [polypeptide binding]; other site
293826001900	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826001901	DNA binding site [nucleotide binding]
293826001902	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826001903	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826001904	dimerization interface [polypeptide binding]; other site
293826001905	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826001906	dimer interface [polypeptide binding]; other site
293826001907	phosphorylation site [posttranslational modification]
293826001908	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826001909	ATP binding site [chemical binding]; other site
293826001910	Mg2+ binding site [ion binding]; other site
293826001911	G-X-G motif; other site
293826001912	Sporulation and spore germination; Region: Germane; pfam10646
293826001913	Predicted permeases [General function prediction only]; Region: COG0679
293826001914	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
293826001915	N-acetyl-D-glucosamine binding site [chemical binding]; other site
293826001916	catalytic residue [active]
293826001917	S-layer homology domain; Region: SLH; pfam00395
293826001918	S-layer homology domain; Region: SLH; pfam00395
293826001919	S-layer homology domain; Region: SLH; pfam00395
293826001920	Protein of unknown function (DUF1256); Region: DUF1256; pfam06866
293826001921	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
293826001922	S-adenosylmethionine synthetase; Validated; Region: PRK05250
293826001923	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
293826001924	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
293826001925	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
293826001926	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
293826001927	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826001928	HAMP domain; Region: HAMP; pfam00672
293826001929	dimerization interface [polypeptide binding]; other site
293826001930	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
293826001931	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826001932	dimer interface [polypeptide binding]; other site
293826001933	putative CheW interface [polypeptide binding]; other site
293826001934	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
293826001935	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
293826001936	YvrJ protein family; Region: YvrJ; pfam12841
293826001937	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
293826001938	AAA domain; Region: AAA_30; pfam13604
293826001939	Family description; Region: UvrD_C_2; pfam13538
293826001940	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
293826001941	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
293826001942	active site
293826001943	flagellar operon protein TIGR03826; Region: YvyF
293826001944	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
293826001945	FlgN protein; Region: FlgN; pfam05130
293826001946	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
293826001947	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
293826001948	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
293826001949	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
293826001950	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
293826001951	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
293826001952	flagellar assembly protein FliW; Provisional; Region: PRK13285
293826001953	carbon storage regulator; Provisional; Region: PRK01712
293826001954	flagellin; Reviewed; Region: PRK08869
293826001955	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
293826001956	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
293826001957	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826001958	binding surface
293826001959	TPR motif; other site
293826001960	Tetratricopeptide repeat; Region: TPR_16; pfam13432
293826001961	Methyltransferase domain; Region: Methyltransf_18; pfam12847
293826001962	Invasion plasmid antigen IpaD; Region: IpaD; cl05827
293826001963	Putative motility protein; Region: YjfB_motility; pfam14070
293826001964	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
293826001965	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
293826001966	active site
293826001967	NTP binding site [chemical binding]; other site
293826001968	metal binding triad [ion binding]; metal-binding site
293826001969	antibiotic binding site [chemical binding]; other site
293826001970	Putative motility protein; Region: YjfB_motility; pfam14070
293826001971	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
293826001972	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
293826001973	Putative motility protein; Region: YjfB_motility; pfam14070
293826001974	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
293826001975	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
293826001976	Transposase IS200 like; Region: Y1_Tnp; pfam01797
293826001977	Rubrerythrin [Energy production and conversion]; Region: COG1592
293826001978	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
293826001979	diiron binding motif [ion binding]; other site
293826001980	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826001981	Zn2+ binding site [ion binding]; other site
293826001982	Mg2+ binding site [ion binding]; other site
293826001983	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
293826001984	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826001985	non-specific DNA binding site [nucleotide binding]; other site
293826001986	salt bridge; other site
293826001987	sequence-specific DNA binding site [nucleotide binding]; other site
293826001988	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
293826001989	active site
293826001990	NTP binding site [chemical binding]; other site
293826001991	metal binding triad [ion binding]; metal-binding site
293826001992	antibiotic binding site [chemical binding]; other site
293826001993	HEPN domain; Region: HEPN; pfam05168
293826001994	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
293826001995	FMN-binding domain; Region: FMN_bind; cl01081
293826001996	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
293826001997	L-aspartate oxidase; Provisional; Region: PRK06175
293826001998	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
293826001999	putative FMN binding site [chemical binding]; other site
293826002000	EDD domain protein, DegV family; Region: DegV; TIGR00762
293826002001	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
293826002002	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
293826002003	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
293826002004	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826002005	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
293826002006	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
293826002007	FAD binding domain; Region: FAD_binding_4; pfam01565
293826002008	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
293826002009	Ligand binding site [chemical binding]; other site
293826002010	Electron transfer flavoprotein domain; Region: ETF; pfam01012
293826002011	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
293826002012	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
293826002013	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
293826002014	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
293826002015	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
293826002016	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
293826002017	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
293826002018	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826002019	Coenzyme A binding pocket [chemical binding]; other site
293826002020	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
293826002021	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826002022	Coenzyme A binding pocket [chemical binding]; other site
293826002023	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826002024	Zn2+ binding site [ion binding]; other site
293826002025	Mg2+ binding site [ion binding]; other site
293826002026	HDOD domain; Region: HDOD; pfam08668
293826002027	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826002028	Zn2+ binding site [ion binding]; other site
293826002029	Mg2+ binding site [ion binding]; other site
293826002030	Transporter associated domain; Region: CorC_HlyC; smart01091
293826002031	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
293826002032	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
293826002033	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
293826002034	Predicted integral membrane protein [Function unknown]; Region: COG5652
293826002035	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
293826002036	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
293826002037	Beta-Casp domain; Region: Beta-Casp; smart01027
293826002038	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
293826002039	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
293826002040	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
293826002041	Domain of unknown function (DUF1850); Region: DUF1850; pfam08905
293826002042	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
293826002043	DctM-like transporters; Region: DctM; pfam06808
293826002044	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
293826002045	DNA binding residues [nucleotide binding]
293826002046	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
293826002047	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
293826002048	substrate-cofactor binding pocket; other site
293826002049	homodimer interface [polypeptide binding]; other site
293826002050	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826002051	catalytic residue [active]
293826002052	FlaG protein; Region: FlaG; pfam03646
293826002053	flagellar capping protein; Validated; Region: fliD; PRK07737
293826002054	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
293826002055	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
293826002056	Flagellar protein FliS; Region: FliS; cl00654
293826002057	FlgN protein; Region: FlgN; pfam05130
293826002058	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
293826002059	30S subunit binding site; other site
293826002060	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
293826002061	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
293826002062	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
293826002063	nucleotide binding region [chemical binding]; other site
293826002064	peptide chain release factor 2; Provisional; Region: PRK05589
293826002065	PCRF domain; Region: PCRF; pfam03462
293826002066	RF-1 domain; Region: RF-1; pfam00472
293826002067	Protein of unknown function (DUF327); Region: DUF327; pfam03885
293826002068	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
293826002069	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
293826002070	flagellin; Provisional; Region: PRK12804
293826002071	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
293826002072	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
293826002073	Flagellar protein FliS; Region: FliS; cl00654
293826002074	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
293826002075	Sulfatase; Region: Sulfatase; pfam00884
293826002076	SurA N-terminal domain; Region: SurA_N_3; cl07813
293826002077	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
293826002078	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
293826002079	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
293826002080	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
293826002081	RNA binding site [nucleotide binding]; other site
293826002082	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
293826002083	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
293826002084	putative substrate translocation pore; other site
293826002085	Predicted membrane protein [Function unknown]; Region: COG3601
293826002086	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
293826002087	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
293826002088	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
293826002089	Glycoprotease family; Region: Peptidase_M22; pfam00814
293826002090	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
293826002091	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826002092	Coenzyme A binding pocket [chemical binding]; other site
293826002093	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826002094	Walker A/P-loop; other site
293826002095	ATP binding site [chemical binding]; other site
293826002096	Q-loop/lid; other site
293826002097	UGMP family protein; Validated; Region: PRK09604
293826002098	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
293826002099	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
293826002100	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826002101	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826002102	ABC transporter; Region: ABC_tran_2; pfam12848
293826002103	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826002104	ABC transporter; Region: ABC_tran_2; pfam12848
293826002105	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
293826002106	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
293826002107	CoA binding domain; Region: CoA_binding; pfam02629
293826002108	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
293826002109	MarR family; Region: MarR_2; cl17246
293826002110	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
293826002111	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
293826002112	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
293826002113	Asp23 family; Region: Asp23; pfam03780
293826002114	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
293826002115	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
293826002116	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
293826002117	NAD(P) binding site [chemical binding]; other site
293826002118	L-lactate permease; Region: Lactate_perm; cl00701
293826002119	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
293826002120	Transcriptional regulators [Transcription]; Region: FadR; COG2186
293826002121	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826002122	DNA-binding site [nucleotide binding]; DNA binding site
293826002123	FCD domain; Region: FCD; pfam07729
293826002124	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
293826002125	Ligand binding site [chemical binding]; other site
293826002126	Electron transfer flavoprotein domain; Region: ETF; pfam01012
293826002127	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
293826002128	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
293826002129	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
293826002130	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
293826002131	FAD binding domain; Region: FAD_binding_4; pfam01565
293826002132	Domain of unknown function DUF77; Region: DUF77; pfam01910
293826002133	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
293826002134	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
293826002135	Walker A/P-loop; other site
293826002136	ATP binding site [chemical binding]; other site
293826002137	Q-loop/lid; other site
293826002138	ABC transporter signature motif; other site
293826002139	Walker B; other site
293826002140	D-loop; other site
293826002141	H-loop/switch region; other site
293826002142	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
293826002143	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
293826002144	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
293826002145	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
293826002146	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
293826002147	putative substrate binding site [chemical binding]; other site
293826002148	putative ATP binding site [chemical binding]; other site
293826002149	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
293826002150	active site
293826002151	phosphorylation site [posttranslational modification]
293826002152	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
293826002153	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
293826002154	active site
293826002155	P-loop; other site
293826002156	phosphorylation site [posttranslational modification]
293826002157	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
293826002158	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
293826002159	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826002160	Coenzyme A binding pocket [chemical binding]; other site
293826002161	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
293826002162	8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588
293826002163	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
293826002164	helix-hairpin-helix signature motif; other site
293826002165	substrate binding pocket [chemical binding]; other site
293826002166	active site
293826002167	Protein of unknown function (DUF554); Region: DUF554; pfam04474
293826002168	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
293826002169	oligomerisation interface [polypeptide binding]; other site
293826002170	mobile loop; other site
293826002171	roof hairpin; other site
293826002172	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
293826002173	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
293826002174	ring oligomerisation interface [polypeptide binding]; other site
293826002175	ATP/Mg binding site [chemical binding]; other site
293826002176	stacking interactions; other site
293826002177	hinge regions; other site
293826002178	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
293826002179	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
293826002180	Int/Topo IB signature motif; other site
293826002181	Domain of unknown function (DUF955); Region: DUF955; cl01076
293826002182	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826002183	non-specific DNA binding site [nucleotide binding]; other site
293826002184	salt bridge; other site
293826002185	sequence-specific DNA binding site [nucleotide binding]; other site
293826002186	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
293826002187	non-specific DNA binding site [nucleotide binding]; other site
293826002188	salt bridge; other site
293826002189	sequence-specific DNA binding site [nucleotide binding]; other site
293826002190	Helix-turn-helix domain; Region: HTH_17; pfam12728
293826002191	Prophage antirepressor [Transcription]; Region: COG3617
293826002192	BRO family, N-terminal domain; Region: Bro-N; smart01040
293826002193	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
293826002194	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
293826002195	Homeodomain-like domain; Region: HTH_23; cl17451
293826002196	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826002197	Walker A/P-loop; other site
293826002198	ATP binding site [chemical binding]; other site
293826002199	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
293826002200	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
293826002201	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
293826002202	ATP binding site [chemical binding]; other site
293826002203	putative Mg++ binding site [ion binding]; other site
293826002204	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
293826002205	nucleotide binding region [chemical binding]; other site
293826002206	ATP-binding site [chemical binding]; other site
293826002207	HsdM N-terminal domain; Region: HsdM_N; pfam12161
293826002208	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
293826002209	Methyltransferase domain; Region: Methyltransf_26; pfam13659
293826002210	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
293826002211	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
293826002212	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
293826002213	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826002214	AAA domain; Region: AAA_21; pfam13304
293826002215	Walker A/P-loop; other site
293826002216	ATP binding site [chemical binding]; other site
293826002217	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
293826002218	ABC transporter signature motif; other site
293826002219	Walker B; other site
293826002220	D-loop; other site
293826002221	H-loop/switch region; other site
293826002222	TIGR02646 family protein; Region: TIGR02646
293826002223	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
293826002224	Domain of unknown function (DUF4268); Region: DUF4268; pfam14088
293826002225	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826002226	non-specific DNA binding site [nucleotide binding]; other site
293826002227	salt bridge; other site
293826002228	sequence-specific DNA binding site [nucleotide binding]; other site
293826002229	Domain of unknown function (DUF955); Region: DUF955; cl01076
293826002230	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
293826002231	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
293826002232	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
293826002233	Peptidase M15; Region: Peptidase_M15_3; cl01194
293826002234	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
293826002235	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
293826002236	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826002237	non-specific DNA binding site [nucleotide binding]; other site
293826002238	salt bridge; other site
293826002239	sequence-specific DNA binding site [nucleotide binding]; other site
293826002240	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
293826002241	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
293826002242	trimer interface [polypeptide binding]; other site
293826002243	active site
293826002244	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
293826002245	trimer interface [polypeptide binding]; other site
293826002246	active site
293826002247	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
293826002248	Spore germination protein; Region: Spore_permease; cl17796
293826002249	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
293826002250	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
293826002251	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
293826002252	Domain of unknown function (DUF4268); Region: DUF4268; pfam14088
293826002253	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
293826002254	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826002255	non-specific DNA binding site [nucleotide binding]; other site
293826002256	salt bridge; other site
293826002257	sequence-specific DNA binding site [nucleotide binding]; other site
293826002258	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
293826002259	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826002260	EamA-like transporter family; Region: EamA; pfam00892
293826002261	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
293826002262	EamA-like transporter family; Region: EamA; pfam00892
293826002263	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
293826002264	dimer interface [polypeptide binding]; other site
293826002265	putative tRNA-binding site [nucleotide binding]; other site
293826002266	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
293826002267	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
293826002268	active site
293826002269	motif I; other site
293826002270	motif II; other site
293826002271	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
293826002272	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
293826002273	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
293826002274	substrate binding site [chemical binding]; other site
293826002275	ATP binding site [chemical binding]; other site
293826002276	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
293826002277	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
293826002278	active site
293826002279	metal binding site [ion binding]; metal-binding site
293826002280	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
293826002281	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
293826002282	Walker A/P-loop; other site
293826002283	ATP binding site [chemical binding]; other site
293826002284	Q-loop/lid; other site
293826002285	ABC transporter signature motif; other site
293826002286	Walker B; other site
293826002287	D-loop; other site
293826002288	H-loop/switch region; other site
293826002289	TOBE domain; Region: TOBE; pfam03459
293826002290	TOBE domain; Region: TOBE_2; pfam08402
293826002291	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
293826002292	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
293826002293	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
293826002294	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
293826002295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826002296	dimer interface [polypeptide binding]; other site
293826002297	conserved gate region; other site
293826002298	putative PBP binding loops; other site
293826002299	ABC-ATPase subunit interface; other site
293826002300	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
293826002301	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826002302	dimer interface [polypeptide binding]; other site
293826002303	conserved gate region; other site
293826002304	putative PBP binding loops; other site
293826002305	ABC-ATPase subunit interface; other site
293826002306	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
293826002307	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
293826002308	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
293826002309	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
293826002310	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
293826002311	NADP binding site [chemical binding]; other site
293826002312	homodimer interface [polypeptide binding]; other site
293826002313	active site
293826002314	Transcriptional regulators [Transcription]; Region: PurR; COG1609
293826002315	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
293826002316	DNA binding site [nucleotide binding]
293826002317	domain linker motif; other site
293826002318	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
293826002319	dimerization interface [polypeptide binding]; other site
293826002320	ligand binding site [chemical binding]; other site
293826002321	Coat F domain; Region: Coat_F; pfam07875
293826002322	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
293826002323	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
293826002324	active site
293826002325	catalytic tetrad [active]
293826002326	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
293826002327	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
293826002328	PHB binding site; other site
293826002329	subunit interaction site [polypeptide binding]; other site
293826002330	CoenzymeA binding site [chemical binding]; other site
293826002331	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
293826002332	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
293826002333	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
293826002334	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
293826002335	active site
293826002336	GMP synthase; Reviewed; Region: guaA; PRK00074
293826002337	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
293826002338	AMP/PPi binding site [chemical binding]; other site
293826002339	candidate oxyanion hole; other site
293826002340	catalytic triad [active]
293826002341	potential glutamine specificity residues [chemical binding]; other site
293826002342	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
293826002343	ATP Binding subdomain [chemical binding]; other site
293826002344	Ligand Binding sites [chemical binding]; other site
293826002345	Dimerization subdomain; other site
293826002346	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
293826002347	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
293826002348	Ion transport protein; Region: Ion_trans; pfam00520
293826002349	Ion channel; Region: Ion_trans_2; pfam07885
293826002350	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
293826002351	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
293826002352	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
293826002353	ATP-grasp domain; Region: ATP-grasp; pfam02222
293826002354	AIR carboxylase; Region: AIRC; pfam00731
293826002355	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
293826002356	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
293826002357	ATP binding site [chemical binding]; other site
293826002358	active site
293826002359	substrate binding site [chemical binding]; other site
293826002360	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
293826002361	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
293826002362	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
293826002363	putative active site [active]
293826002364	catalytic triad [active]
293826002365	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
293826002366	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
293826002367	dimerization interface [polypeptide binding]; other site
293826002368	ATP binding site [chemical binding]; other site
293826002369	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
293826002370	dimerization interface [polypeptide binding]; other site
293826002371	ATP binding site [chemical binding]; other site
293826002372	amidophosphoribosyltransferase; Provisional; Region: PRK05793
293826002373	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
293826002374	active site
293826002375	tetramer interface [polypeptide binding]; other site
293826002376	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
293826002377	active site
293826002378	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
293826002379	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
293826002380	dimerization interface [polypeptide binding]; other site
293826002381	putative ATP binding site [chemical binding]; other site
293826002382	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
293826002383	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
293826002384	active site
293826002385	substrate binding site [chemical binding]; other site
293826002386	cosubstrate binding site; other site
293826002387	catalytic site [active]
293826002388	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
293826002389	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
293826002390	purine monophosphate binding site [chemical binding]; other site
293826002391	dimer interface [polypeptide binding]; other site
293826002392	putative catalytic residues [active]
293826002393	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
293826002394	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
293826002395	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
293826002396	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
293826002397	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
293826002398	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
293826002399	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
293826002400	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
293826002401	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
293826002402	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
293826002403	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826002404	dimer interface [polypeptide binding]; other site
293826002405	putative CheW interface [polypeptide binding]; other site
293826002406	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
293826002407	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
293826002408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826002409	dimer interface [polypeptide binding]; other site
293826002410	conserved gate region; other site
293826002411	ABC-ATPase subunit interface; other site
293826002412	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
293826002413	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
293826002414	Walker A/P-loop; other site
293826002415	ATP binding site [chemical binding]; other site
293826002416	Q-loop/lid; other site
293826002417	ABC transporter signature motif; other site
293826002418	Walker B; other site
293826002419	D-loop; other site
293826002420	H-loop/switch region; other site
293826002421	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
293826002422	Trp repressor protein; Region: Trp_repressor; cl17266
293826002423	aspartate kinase I; Reviewed; Region: PRK08210
293826002424	AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of  the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260
293826002425	putative catalytic residues [active]
293826002426	putative nucleotide binding site [chemical binding]; other site
293826002427	putative aspartate binding site [chemical binding]; other site
293826002428	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
293826002429	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937
293826002430	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
293826002431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826002432	active site
293826002433	phosphorylation site [posttranslational modification]
293826002434	intermolecular recognition site; other site
293826002435	dimerization interface [polypeptide binding]; other site
293826002436	PAS domain S-box; Region: sensory_box; TIGR00229
293826002437	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826002438	PAS fold; Region: PAS_3; pfam08447
293826002439	putative active site [active]
293826002440	heme pocket [chemical binding]; other site
293826002441	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
293826002442	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
293826002443	metal binding site [ion binding]; metal-binding site
293826002444	active site
293826002445	I-site; other site
293826002446	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826002447	Zn2+ binding site [ion binding]; other site
293826002448	Mg2+ binding site [ion binding]; other site
293826002449	HAMP domain; Region: HAMP; pfam00672
293826002450	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
293826002451	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826002452	dimer interface [polypeptide binding]; other site
293826002453	putative CheW interface [polypeptide binding]; other site
293826002454	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
293826002455	Part of AAA domain; Region: AAA_19; pfam13245
293826002456	Family description; Region: UvrD_C_2; pfam13538
293826002457	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
293826002458	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
293826002459	nucleotide binding pocket [chemical binding]; other site
293826002460	K-X-D-G motif; other site
293826002461	catalytic site [active]
293826002462	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
293826002463	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
293826002464	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
293826002465	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
293826002466	Dimer interface [polypeptide binding]; other site
293826002467	BRCT sequence motif; other site
293826002468	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
293826002469	Rubrerythrin [Energy production and conversion]; Region: COG1592
293826002470	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
293826002471	binuclear metal center [ion binding]; other site
293826002472	FeoA domain; Region: FeoA; pfam04023
293826002473	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
293826002474	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
293826002475	G1 box; other site
293826002476	GTP/Mg2+ binding site [chemical binding]; other site
293826002477	Switch I region; other site
293826002478	G2 box; other site
293826002479	G3 box; other site
293826002480	Switch II region; other site
293826002481	G4 box; other site
293826002482	G5 box; other site
293826002483	Nucleoside recognition; Region: Gate; pfam07670
293826002484	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
293826002485	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
293826002486	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
293826002487	AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061
293826002488	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309
293826002489	dimerization interface [polypeptide binding]; other site
293826002490	putative ATP binding site [chemical binding]; other site
293826002491	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
293826002492	AMIN domain; Region: AMIN; pfam11741
293826002493	AMIN domain; Region: AMIN; pfam11741
293826002494	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
293826002495	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
293826002496	active site
293826002497	metal binding site [ion binding]; metal-binding site
293826002498	hypothetical protein; Provisional; Region: PRK04164
293826002499	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
293826002500	Sporulation and spore germination; Region: Germane; pfam10646
293826002501	Sporulation and spore germination; Region: Germane; pfam10646
293826002502	ribonuclease PH; Reviewed; Region: rph; PRK00173
293826002503	Ribonuclease PH; Region: RNase_PH_bact; cd11362
293826002504	hexamer interface [polypeptide binding]; other site
293826002505	active site
293826002506	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
293826002507	active site
293826002508	dimerization interface [polypeptide binding]; other site
293826002509	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
293826002510	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
293826002511	active site
293826002512	metal binding site [ion binding]; metal-binding site
293826002513	homotetramer interface [polypeptide binding]; other site
293826002514	S-layer homology domain; Region: SLH; pfam00395
293826002515	S-layer homology domain; Region: SLH; pfam00395
293826002516	S-layer homology domain; Region: SLH; pfam00395
293826002517	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
293826002518	Transposase IS200 like; Region: Y1_Tnp; pfam01797
293826002519	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
293826002520	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
293826002521	Probable transposase; Region: OrfB_IS605; pfam01385
293826002522	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
293826002523	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826002524	dimerization interface [polypeptide binding]; other site
293826002525	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826002526	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
293826002527	putative active site [active]
293826002528	heme pocket [chemical binding]; other site
293826002529	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826002530	putative active site [active]
293826002531	heme pocket [chemical binding]; other site
293826002532	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
293826002533	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
293826002534	metal binding site [ion binding]; metal-binding site
293826002535	active site
293826002536	I-site; other site
293826002537	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
293826002538	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826002539	Zn2+ binding site [ion binding]; other site
293826002540	Mg2+ binding site [ion binding]; other site
293826002541	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
293826002542	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
293826002543	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
293826002544	DctM-like transporters; Region: DctM; pfam06808
293826002545	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
293826002546	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
293826002547	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
293826002548	active site
293826002549	motif I; other site
293826002550	motif II; other site
293826002551	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
293826002552	Predicted dehydrogenase [General function prediction only]; Region: COG0579
293826002553	hydroxyglutarate oxidase; Provisional; Region: PRK11728
293826002554	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
293826002555	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
293826002556	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
293826002557	Protein of unknown function (DUF1667); Region: DUF1667; pfam07892
293826002558	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
293826002559	MgtC family; Region: MgtC; pfam02308
293826002560	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
293826002561	Transcriptional regulator [Transcription]; Region: LysR; COG0583
293826002562	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
293826002563	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
293826002564	putative dimerization interface [polypeptide binding]; other site
293826002565	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
293826002566	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
293826002567	dimerization interface [polypeptide binding]; other site
293826002568	putative DNA binding site [nucleotide binding]; other site
293826002569	putative Zn2+ binding site [ion binding]; other site
293826002570	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
293826002571	Low molecular weight phosphatase family; Region: LMWPc; cd00115
293826002572	active site
293826002573	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
293826002574	Sodium Bile acid symporter family; Region: SBF; cl17470
293826002575	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
293826002576	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
293826002577	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
293826002578	P loop; other site
293826002579	Nucleotide binding site [chemical binding]; other site
293826002580	DTAP/Switch II; other site
293826002581	Switch I; other site
293826002582	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
293826002583	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
293826002584	P loop; other site
293826002585	Nucleotide binding site [chemical binding]; other site
293826002586	DTAP/Switch II; other site
293826002587	Switch I; other site
293826002588	tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317
293826002589	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826002590	FeS/SAM binding site; other site
293826002591	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
293826002592	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
293826002593	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
293826002594	GTP binding site; other site
293826002595	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
293826002596	This CD includes the respiratory arsenate reductase, As(V), catalytic subunit (ArrA) and other related proteins. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_Arsenate-R; cd02757
293826002597	putative [Fe4-S4] binding site [ion binding]; other site
293826002598	putative molybdopterin cofactor binding site [chemical binding]; other site
293826002599	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
293826002600	putative molybdopterin cofactor binding site; other site
293826002601	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
293826002602	4Fe-4S binding domain; Region: Fer4; pfam00037
293826002603	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
293826002604	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
293826002605	4Fe-4S binding domain; Region: Fer4; pfam00037
293826002606	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
293826002607	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
293826002608	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
293826002609	putative MPT binding site; other site
293826002610	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
293826002611	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
293826002612	dimer interface [polypeptide binding]; other site
293826002613	putative functional site; other site
293826002614	putative MPT binding site; other site
293826002615	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
293826002616	Walker A motif; other site
293826002617	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
293826002618	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
293826002619	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
293826002620	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
293826002621	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
293826002622	RNase E interface [polypeptide binding]; other site
293826002623	trimer interface [polypeptide binding]; other site
293826002624	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
293826002625	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
293826002626	RNase E interface [polypeptide binding]; other site
293826002627	trimer interface [polypeptide binding]; other site
293826002628	active site
293826002629	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
293826002630	putative nucleic acid binding region [nucleotide binding]; other site
293826002631	G-X-X-G motif; other site
293826002632	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
293826002633	RNA binding site [nucleotide binding]; other site
293826002634	domain interface; other site
293826002635	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826002636	S-adenosylmethionine binding site [chemical binding]; other site
293826002637	Helix-turn-helix domain; Region: HTH_17; pfam12728
293826002638	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
293826002639	Part of AAA domain; Region: AAA_19; pfam13245
293826002640	Pyruvate formate lyase; Region: PFL; pfam02901
293826002641	Family description; Region: UvrD_C_2; pfam13538
293826002642	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
293826002643	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
293826002644	RNase E interface [polypeptide binding]; other site
293826002645	trimer interface [polypeptide binding]; other site
293826002646	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
293826002647	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
293826002648	RNase E interface [polypeptide binding]; other site
293826002649	trimer interface [polypeptide binding]; other site
293826002650	active site
293826002651	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
293826002652	putative nucleic acid binding region [nucleotide binding]; other site
293826002653	G-X-X-G motif; other site
293826002654	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
293826002655	RNA binding site [nucleotide binding]; other site
293826002656	domain interface; other site
293826002657	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686
293826002658	nudix motif; other site
293826002659	Helix-turn-helix domain; Region: HTH_17; pfam12728
293826002660	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
293826002661	Major Facilitator Superfamily; Region: MFS_1; pfam07690
293826002662	putative substrate translocation pore; other site
293826002663	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
293826002664	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
293826002665	Sulfate transporter family; Region: Sulfate_transp; pfam00916
293826002666	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
293826002667	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
293826002668	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
293826002669	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826002670	PAS fold; Region: PAS_3; pfam08447
293826002671	putative active site [active]
293826002672	heme pocket [chemical binding]; other site
293826002673	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826002674	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826002675	dimer interface [polypeptide binding]; other site
293826002676	phosphorylation site [posttranslational modification]
293826002677	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826002678	ATP binding site [chemical binding]; other site
293826002679	Mg2+ binding site [ion binding]; other site
293826002680	G-X-G motif; other site
293826002681	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826002682	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826002683	dimer interface [polypeptide binding]; other site
293826002684	phosphorylation site [posttranslational modification]
293826002685	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826002686	ATP binding site [chemical binding]; other site
293826002687	Mg2+ binding site [ion binding]; other site
293826002688	G-X-G motif; other site
293826002689	Response regulator receiver domain; Region: Response_reg; pfam00072
293826002690	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826002691	active site
293826002692	phosphorylation site [posttranslational modification]
293826002693	intermolecular recognition site; other site
293826002694	dimerization interface [polypeptide binding]; other site
293826002695	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
293826002696	putative binding surface; other site
293826002697	active site
293826002698	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826002699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826002700	active site
293826002701	phosphorylation site [posttranslational modification]
293826002702	intermolecular recognition site; other site
293826002703	dimerization interface [polypeptide binding]; other site
293826002704	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826002705	DNA binding site [nucleotide binding]
293826002706	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
293826002707	Nucleoside recognition; Region: Gate; pfam07670
293826002708	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
293826002709	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
293826002710	catalytic motif [active]
293826002711	Zn binding site [ion binding]; other site
293826002712	RibD C-terminal domain; Region: RibD_C; cl17279
293826002713	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
293826002714	Lumazine binding domain; Region: Lum_binding; pfam00677
293826002715	Lumazine binding domain; Region: Lum_binding; pfam00677
293826002716	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
293826002717	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
293826002718	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
293826002719	dimerization interface [polypeptide binding]; other site
293826002720	active site
293826002721	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
293826002722	homopentamer interface [polypeptide binding]; other site
293826002723	active site
293826002724	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
293826002725	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
293826002726	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826002727	dimer interface [polypeptide binding]; other site
293826002728	conserved gate region; other site
293826002729	putative PBP binding loops; other site
293826002730	ABC-ATPase subunit interface; other site
293826002731	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
293826002732	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826002733	Walker A/P-loop; other site
293826002734	ATP binding site [chemical binding]; other site
293826002735	Q-loop/lid; other site
293826002736	ABC transporter signature motif; other site
293826002737	Walker B; other site
293826002738	D-loop; other site
293826002739	H-loop/switch region; other site
293826002740	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
293826002741	Transcriptional regulator [Transcription]; Region: LytR; COG1316
293826002742	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
293826002743	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
293826002744	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
293826002745	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
293826002746	putative active site [active]
293826002747	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
293826002748	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826002749	Walker A/P-loop; other site
293826002750	ATP binding site [chemical binding]; other site
293826002751	Q-loop/lid; other site
293826002752	ABC transporter signature motif; other site
293826002753	Walker B; other site
293826002754	D-loop; other site
293826002755	H-loop/switch region; other site
293826002756	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
293826002757	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
293826002758	HlyD family secretion protein; Region: HlyD_3; pfam13437
293826002759	CAAX protease self-immunity; Region: Abi; pfam02517
293826002760	CAAX protease self-immunity; Region: Abi; pfam02517
293826002761	COMC family; Region: ComC; pfam03047
293826002762	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
293826002763	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826002764	FeS/SAM binding site; other site
293826002765	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
293826002766	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826002767	binding surface
293826002768	TPR motif; other site
293826002769	TPR repeat; Region: TPR_11; pfam13414
293826002770	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826002771	binding surface
293826002772	TPR motif; other site
293826002773	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
293826002774	DNA binding residues [nucleotide binding]
293826002775	class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949
293826002776	CAAX protease self-immunity; Region: Abi; pfam02517
293826002777	transposase/IS protein; Provisional; Region: PRK09183
293826002778	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826002779	Walker A motif; other site
293826002780	ATP binding site [chemical binding]; other site
293826002781	Walker B motif; other site
293826002782	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
293826002783	Integrase core domain; Region: rve; pfam00665
293826002784	Transposase domain (DUF772); Region: DUF772; pfam05598
293826002785	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
293826002786	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
293826002787	class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949
293826002788	CAAX protease self-immunity; Region: Abi; pfam02517
293826002789	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
293826002790	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
293826002791	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
293826002792	catalytic residues [active]
293826002793	catalytic nucleophile [active]
293826002794	Recombinase; Region: Recombinase; pfam07508
293826002795	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
293826002796	Recombinase; Region: Recombinase; pfam07508
293826002797	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
293826002798	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
293826002799	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
293826002800	Peptidase M16C associated; Region: M16C_assoc; pfam08367
293826002801	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
293826002802	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
293826002803	DNA binding residues [nucleotide binding]
293826002804	dimerization interface [polypeptide binding]; other site
293826002805	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
293826002806	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
293826002807	active site
293826002808	Zn binding site [ion binding]; other site
293826002809	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826002810	Coenzyme A binding pocket [chemical binding]; other site
293826002811	Predicted amidohydrolase [General function prediction only]; Region: COG0388
293826002812	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
293826002813	putative active site [active]
293826002814	catalytic triad [active]
293826002815	putative dimer interface [polypeptide binding]; other site
293826002816	Transcriptional regulators [Transcription]; Region: PurR; COG1609
293826002817	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
293826002818	DNA binding site [nucleotide binding]
293826002819	domain linker motif; other site
293826002820	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
293826002821	trigger factor; Provisional; Region: tig; PRK01490
293826002822	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
293826002823	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
293826002824	Clp protease; Region: CLP_protease; pfam00574
293826002825	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
293826002826	oligomer interface [polypeptide binding]; other site
293826002827	active site residues [active]
293826002828	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
293826002829	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
293826002830	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826002831	Walker A motif; other site
293826002832	ATP binding site [chemical binding]; other site
293826002833	Walker B motif; other site
293826002834	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
293826002835	Chromate transporter; Region: Chromate_transp; pfam02417
293826002836	Chromate transporter; Region: Chromate_transp; pfam02417
293826002837	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
293826002838	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826002839	Walker A motif; other site
293826002840	ATP binding site [chemical binding]; other site
293826002841	Walker B motif; other site
293826002842	arginine finger; other site
293826002843	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
293826002844	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
293826002845	Found in ATP-dependent protease La (LON); Region: LON; smart00464
293826002846	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826002847	Walker A motif; other site
293826002848	ATP binding site [chemical binding]; other site
293826002849	Walker B motif; other site
293826002850	arginine finger; other site
293826002851	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
293826002852	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
293826002853	G1 box; other site
293826002854	GTP/Mg2+ binding site [chemical binding]; other site
293826002855	Switch I region; other site
293826002856	G2 box; other site
293826002857	G3 box; other site
293826002858	Switch II region; other site
293826002859	G4 box; other site
293826002860	G5 box; other site
293826002861	Dehydroquinase class II; Region: DHquinase_II; pfam01220
293826002862	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
293826002863	trimer interface [polypeptide binding]; other site
293826002864	active site
293826002865	dimer interface [polypeptide binding]; other site
293826002866	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
293826002867	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
293826002868	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
293826002869	shikimate binding site; other site
293826002870	NAD(P) binding site [chemical binding]; other site
293826002871	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
293826002872	EamA-like transporter family; Region: EamA; pfam00892
293826002873	EamA-like transporter family; Region: EamA; pfam00892
293826002874	anthranilate synthase component I; Provisional; Region: PRK13570
293826002875	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
293826002876	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
293826002877	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
293826002878	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
293826002879	glutamine binding [chemical binding]; other site
293826002880	catalytic triad [active]
293826002881	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
293826002882	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
293826002883	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
293826002884	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
293826002885	active site
293826002886	ribulose/triose binding site [chemical binding]; other site
293826002887	phosphate binding site [ion binding]; other site
293826002888	substrate (anthranilate) binding pocket [chemical binding]; other site
293826002889	product (indole) binding pocket [chemical binding]; other site
293826002890	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
293826002891	active site
293826002892	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
293826002893	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
293826002894	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826002895	catalytic residue [active]
293826002896	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
293826002897	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
293826002898	substrate binding site [chemical binding]; other site
293826002899	active site
293826002900	catalytic residues [active]
293826002901	heterodimer interface [polypeptide binding]; other site
293826002902	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
293826002903	Rubredoxin; Region: Rubredoxin; pfam00301
293826002904	iron binding site [ion binding]; other site
293826002905	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
293826002906	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
293826002907	Uncharacterized conserved protein [Function unknown]; Region: COG2968
293826002908	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
293826002909	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
293826002910	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
293826002911	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
293826002912	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
293826002913	active site
293826002914	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
293826002915	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826002916	TPR repeat; Region: TPR_11; pfam13414
293826002917	TPR motif; other site
293826002918	binding surface
293826002919	TPR repeat; Region: TPR_11; pfam13414
293826002920	Major Facilitator Superfamily; Region: MFS_1; pfam07690
293826002921	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
293826002922	putative substrate translocation pore; other site
293826002923	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
293826002924	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
293826002925	metal-binding site [ion binding]
293826002926	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
293826002927	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
293826002928	metal-binding site [ion binding]
293826002929	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
293826002930	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
293826002931	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
293826002932	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826002933	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826002934	active site
293826002935	phosphorylation site [posttranslational modification]
293826002936	intermolecular recognition site; other site
293826002937	dimerization interface [polypeptide binding]; other site
293826002938	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826002939	DNA binding site [nucleotide binding]
293826002940	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826002941	HAMP domain; Region: HAMP; pfam00672
293826002942	dimerization interface [polypeptide binding]; other site
293826002943	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826002944	dimer interface [polypeptide binding]; other site
293826002945	phosphorylation site [posttranslational modification]
293826002946	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826002947	ATP binding site [chemical binding]; other site
293826002948	Mg2+ binding site [ion binding]; other site
293826002949	G-X-G motif; other site
293826002950	YibE/F-like protein; Region: YibE_F; pfam07907
293826002951	exopolyphosphatase; Region: exo_poly_only; TIGR03706
293826002952	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
293826002953	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
293826002954	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
293826002955	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
293826002956	Transposase [DNA replication, recombination, and repair]; Region: COG5421
293826002957	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
293826002958	MarR family; Region: MarR; pfam01047
293826002959	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
293826002960	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
293826002961	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
293826002962	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
293826002963	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
293826002964	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
293826002965	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826002966	dimer interface [polypeptide binding]; other site
293826002967	conserved gate region; other site
293826002968	ABC-ATPase subunit interface; other site
293826002969	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
293826002970	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
293826002971	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826002972	dimer interface [polypeptide binding]; other site
293826002973	conserved gate region; other site
293826002974	putative PBP binding loops; other site
293826002975	ABC-ATPase subunit interface; other site
293826002976	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
293826002977	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
293826002978	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
293826002979	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826002980	Walker A/P-loop; other site
293826002981	ATP binding site [chemical binding]; other site
293826002982	Q-loop/lid; other site
293826002983	ABC transporter signature motif; other site
293826002984	Walker B; other site
293826002985	D-loop; other site
293826002986	H-loop/switch region; other site
293826002987	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
293826002988	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
293826002989	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826002990	Walker A/P-loop; other site
293826002991	ATP binding site [chemical binding]; other site
293826002992	Q-loop/lid; other site
293826002993	ABC transporter signature motif; other site
293826002994	Walker B; other site
293826002995	D-loop; other site
293826002996	H-loop/switch region; other site
293826002997	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
293826002998	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
293826002999	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
293826003000	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_4; cd06254
293826003001	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
293826003002	putative active site [active]
293826003003	Zn binding site [ion binding]; other site
293826003004	This putative domain contains a quite highly conserved sequence of CGGC in its central region; Region: CGGC; smart01078
293826003005	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
293826003006	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
293826003007	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
293826003008	ligand binding site [chemical binding]; other site
293826003009	flexible hinge region; other site
293826003010	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
293826003011	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
293826003012	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
293826003013	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
293826003014	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
293826003015	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
293826003016	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
293826003017	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
293826003018	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
293826003019	Walker A/P-loop; other site
293826003020	ATP binding site [chemical binding]; other site
293826003021	Q-loop/lid; other site
293826003022	ABC transporter signature motif; other site
293826003023	Walker B; other site
293826003024	D-loop; other site
293826003025	H-loop/switch region; other site
293826003026	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
293826003027	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
293826003028	The Phox Homology domain, a phosphoinositide binding module; Region: PX_domain; cl02563
293826003029	phosphoinositide binding site [chemical binding]; other site
293826003030	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
293826003031	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
293826003032	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
293826003033	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
293826003034	substrate binding site [chemical binding]; other site
293826003035	nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789
293826003036	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826003037	dimer interface [polypeptide binding]; other site
293826003038	conserved gate region; other site
293826003039	putative PBP binding loops; other site
293826003040	ABC-ATPase subunit interface; other site
293826003041	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
293826003042	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826003043	dimer interface [polypeptide binding]; other site
293826003044	conserved gate region; other site
293826003045	putative PBP binding loops; other site
293826003046	ABC-ATPase subunit interface; other site
293826003047	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826003048	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
293826003049	Walker A/P-loop; other site
293826003050	ATP binding site [chemical binding]; other site
293826003051	Q-loop/lid; other site
293826003052	ABC transporter signature motif; other site
293826003053	Walker B; other site
293826003054	D-loop; other site
293826003055	H-loop/switch region; other site
293826003056	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
293826003057	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826003058	Walker A/P-loop; other site
293826003059	ATP binding site [chemical binding]; other site
293826003060	Q-loop/lid; other site
293826003061	ABC transporter signature motif; other site
293826003062	Walker B; other site
293826003063	D-loop; other site
293826003064	H-loop/switch region; other site
293826003065	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
293826003066	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
293826003067	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826003068	dimerization interface [polypeptide binding]; other site
293826003069	Histidine kinase; Region: His_kinase; pfam06580
293826003070	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
293826003071	ATP binding site [chemical binding]; other site
293826003072	Mg2+ binding site [ion binding]; other site
293826003073	G-X-G motif; other site
293826003074	Response regulator receiver domain; Region: Response_reg; pfam00072
293826003075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826003076	active site
293826003077	phosphorylation site [posttranslational modification]
293826003078	intermolecular recognition site; other site
293826003079	dimerization interface [polypeptide binding]; other site
293826003080	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
293826003081	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826003082	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
293826003083	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
293826003084	Soluble P-type ATPase [General function prediction only]; Region: COG4087
293826003085	Uncharacterized family 3; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_3; cd10160
293826003086	putative homodimer interface [polypeptide binding]; other site
293826003087	putative homotetramer interface [polypeptide binding]; other site
293826003088	putative metal binding site [ion binding]; other site
293826003089	putative homodimer-homodimer interface [polypeptide binding]; other site
293826003090	DNA topoisomerase III; Provisional; Region: PRK07726
293826003091	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
293826003092	active site
293826003093	putative interdomain interaction site [polypeptide binding]; other site
293826003094	putative metal-binding site [ion binding]; other site
293826003095	putative nucleotide binding site [chemical binding]; other site
293826003096	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
293826003097	domain I; other site
293826003098	DNA binding groove [nucleotide binding]
293826003099	phosphate binding site [ion binding]; other site
293826003100	domain II; other site
293826003101	domain III; other site
293826003102	nucleotide binding site [chemical binding]; other site
293826003103	catalytic site [active]
293826003104	domain IV; other site
293826003105	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
293826003106	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
293826003107	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
293826003108	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
293826003109	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
293826003110	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
293826003111	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
293826003112	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
293826003113	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
293826003114	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
293826003115	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826003116	DNA-binding site [nucleotide binding]; DNA binding site
293826003117	UTRA domain; Region: UTRA; pfam07702
293826003118	Uncharacterized conserved protein [Function unknown]; Region: COG5663
293826003119	phosphonate C-P lyase system protein PhnG; Region: PhnG_redo; TIGR03293
293826003120	phosphonate C-P lyase system protein PhnH; Region: PhnH_redo; TIGR03292
293826003121	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
293826003122	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
293826003123	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
293826003124	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826003125	Walker A/P-loop; other site
293826003126	ATP binding site [chemical binding]; other site
293826003127	Q-loop/lid; other site
293826003128	ABC transporter signature motif; other site
293826003129	Walker B; other site
293826003130	D-loop; other site
293826003131	H-loop/switch region; other site
293826003132	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
293826003133	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
293826003134	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
293826003135	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
293826003136	active site
293826003137	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
293826003138	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826003139	Walker A/P-loop; other site
293826003140	ATP binding site [chemical binding]; other site
293826003141	Q-loop/lid; other site
293826003142	ABC transporter signature motif; other site
293826003143	Walker B; other site
293826003144	D-loop; other site
293826003145	H-loop/switch region; other site
293826003146	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
293826003147	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826003148	dimer interface [polypeptide binding]; other site
293826003149	conserved gate region; other site
293826003150	ABC-ATPase subunit interface; other site
293826003151	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
293826003152	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826003153	dimer interface [polypeptide binding]; other site
293826003154	conserved gate region; other site
293826003155	ABC-ATPase subunit interface; other site
293826003156	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
293826003157	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
293826003158	Walker A/P-loop; other site
293826003159	ATP binding site [chemical binding]; other site
293826003160	Q-loop/lid; other site
293826003161	ABC transporter signature motif; other site
293826003162	Walker B; other site
293826003163	D-loop; other site
293826003164	H-loop/switch region; other site
293826003165	Transposase domain (DUF772); Region: DUF772; pfam05598
293826003166	phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098
293826003167	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
293826003168	GAF domain; Region: GAF_2; pfam13185
293826003169	GAF domain; Region: GAF; cl17456
293826003170	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
293826003171	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826003172	Zn2+ binding site [ion binding]; other site
293826003173	Mg2+ binding site [ion binding]; other site
293826003174	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
293826003175	GAF domain; Region: GAF; pfam01590
293826003176	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
293826003177	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
293826003178	metal binding site [ion binding]; metal-binding site
293826003179	active site
293826003180	I-site; other site
293826003181	cardiolipin synthetase; Reviewed; Region: PRK12452
293826003182	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
293826003183	putative active site [active]
293826003184	catalytic site [active]
293826003185	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
293826003186	putative active site [active]
293826003187	catalytic site [active]
293826003188	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
293826003189	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
293826003190	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
293826003191	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
293826003192	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
293826003193	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
293826003194	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
293826003195	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
293826003196	ABC-ATPase subunit  interface; other site
293826003197	dimer interface [polypeptide binding]; other site
293826003198	putative PBP binding regions; other site
293826003199	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
293826003200	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
293826003201	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
293826003202	ACS interaction site; other site
293826003203	CODH interaction site; other site
293826003204	cubane metal cluster (B-cluster) [ion binding]; other site
293826003205	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
293826003206	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
293826003207	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826003208	S-adenosylmethionine binding site [chemical binding]; other site
293826003209	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
293826003210	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
293826003211	ligand binding site [chemical binding]; other site
293826003212	flexible hinge region; other site
293826003213	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
293826003214	non-specific DNA interactions [nucleotide binding]; other site
293826003215	DNA binding site [nucleotide binding]
293826003216	sequence specific DNA binding site [nucleotide binding]; other site
293826003217	putative cAMP binding site [chemical binding]; other site
293826003218	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
293826003219	putative homodimer interface [polypeptide binding]; other site
293826003220	putative homotetramer interface [polypeptide binding]; other site
293826003221	putative allosteric switch controlling residues; other site
293826003222	putative metal binding site [ion binding]; other site
293826003223	putative homodimer-homodimer interface [polypeptide binding]; other site
293826003224	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
293826003225	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
293826003226	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
293826003227	active site
293826003228	motif I; other site
293826003229	motif II; other site
293826003230	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
293826003231	catalytic residues [active]
293826003232	Bacterial SH3 domain; Region: SH3_3; cl17532
293826003233	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
293826003234	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
293826003235	Heme NO binding; Region: HNOB; pfam07700
293826003236	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
293826003237	HAMP domain; Region: HAMP; pfam00672
293826003238	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826003239	dimer interface [polypeptide binding]; other site
293826003240	putative CheW interface [polypeptide binding]; other site
293826003241	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
293826003242	oligomerization interface [polypeptide binding]; other site
293826003243	active site
293826003244	metal binding site [ion binding]; metal-binding site
293826003245	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
293826003246	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
293826003247	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
293826003248	NAD(P) binding site [chemical binding]; other site
293826003249	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
293826003250	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
293826003251	metal binding site [ion binding]; metal-binding site
293826003252	dimer interface [polypeptide binding]; other site
293826003253	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
293826003254	Transcriptional regulator [Transcription]; Region: IclR; COG1414
293826003255	Bacterial transcriptional regulator; Region: IclR; pfam01614
293826003256	ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993
293826003257	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
293826003258	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
293826003259	active site
293826003260	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
293826003261	EamA-like transporter family; Region: EamA; pfam00892
293826003262	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
293826003263	EamA-like transporter family; Region: EamA; pfam00892
293826003264	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
293826003265	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826003266	Coenzyme A binding pocket [chemical binding]; other site
293826003267	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
293826003268	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
293826003269	TPP-binding site [chemical binding]; other site
293826003270	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
293826003271	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
293826003272	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
293826003273	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
293826003274	dimer interface [polypeptide binding]; other site
293826003275	PYR/PP interface [polypeptide binding]; other site
293826003276	TPP binding site [chemical binding]; other site
293826003277	substrate binding site [chemical binding]; other site
293826003278	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
293826003279	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
293826003280	active site
293826003281	HIGH motif; other site
293826003282	dimer interface [polypeptide binding]; other site
293826003283	KMSKS motif; other site
293826003284	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
293826003285	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
293826003286	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
293826003287	MgtC family; Region: MgtC; pfam02308
293826003288	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
293826003289	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
293826003290	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
293826003291	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
293826003292	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
293826003293	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
293826003294	TPP-binding site [chemical binding]; other site
293826003295	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
293826003296	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
293826003297	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
293826003298	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
293826003299	dimer interface [polypeptide binding]; other site
293826003300	PYR/PP interface [polypeptide binding]; other site
293826003301	TPP binding site [chemical binding]; other site
293826003302	substrate binding site [chemical binding]; other site
293826003303	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
293826003304	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
293826003305	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
293826003306	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
293826003307	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
293826003308	motif II; other site
293826003309	Domain of unknown function (DUF1893); Region: TM1506; pfam08973
293826003310	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
293826003311	S1 domain; Region: S1_2; pfam13509
293826003312	S1 domain; Region: S1_2; pfam13509
293826003313	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
293826003314	Asp23 family; Region: Asp23; pfam03780
293826003315	acyl carrier protein; Provisional; Region: acpP; PRK00982
293826003316	Rubredoxin; Region: Rubredoxin; pfam00301
293826003317	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350
293826003318	iron binding site [ion binding]; other site
293826003319	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
293826003320	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
293826003321	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
293826003322	PhoU domain; Region: PhoU; pfam01895
293826003323	PhoU domain; Region: PhoU; pfam01895
293826003324	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
293826003325	proposed catalytic triad [active]
293826003326	active site nucleophile [active]
293826003327	cyanophycin synthetase; Provisional; Region: PRK14016
293826003328	ATP-grasp domain; Region: ATP-grasp_4; cl17255
293826003329	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
293826003330	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
293826003331	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
293826003332	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
293826003333	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
293826003334	dimerization interface [polypeptide binding]; other site
293826003335	putative DNA binding site [nucleotide binding]; other site
293826003336	putative Zn2+ binding site [ion binding]; other site
293826003337	Predicted permeases [General function prediction only]; Region: COG0701
293826003338	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
293826003339	Transposase [DNA replication, recombination, and repair]; Region: COG5421
293826003340	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
293826003341	ApbE family; Region: ApbE; pfam02424
293826003342	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
293826003343	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
293826003344	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
293826003345	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
293826003346	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
293826003347	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
293826003348	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
293826003349	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
293826003350	catalytic residue [active]
293826003351	putative FPP diphosphate  binding site; other site
293826003352	putative FPP binding hydrophobic cleft; other site
293826003353	dimer interface [polypeptide binding]; other site
293826003354	putative IPP diphosphate binding site; other site
293826003355	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
293826003356	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
293826003357	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
293826003358	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
293826003359	Walker A/P-loop; other site
293826003360	ATP binding site [chemical binding]; other site
293826003361	Q-loop/lid; other site
293826003362	ABC transporter signature motif; other site
293826003363	Walker B; other site
293826003364	D-loop; other site
293826003365	H-loop/switch region; other site
293826003366	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
293826003367	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826003368	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
293826003369	dimer interface [polypeptide binding]; other site
293826003370	conserved gate region; other site
293826003371	putative PBP binding loops; other site
293826003372	ABC-ATPase subunit interface; other site
293826003373	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
293826003374	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
293826003375	substrate binding pocket [chemical binding]; other site
293826003376	membrane-bound complex binding site; other site
293826003377	hinge residues; other site
293826003378	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
293826003379	MgtC family; Region: MgtC; pfam02308
293826003380	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
293826003381	Transposase [DNA replication, recombination, and repair]; Region: COG5421
293826003382	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
293826003383	thiamine phosphate binding site [chemical binding]; other site
293826003384	active site
293826003385	pyrophosphate binding site [ion binding]; other site
293826003386	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
293826003387	substrate binding site [chemical binding]; other site
293826003388	multimerization interface [polypeptide binding]; other site
293826003389	ATP binding site [chemical binding]; other site
293826003390	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
293826003391	dimer interface [polypeptide binding]; other site
293826003392	substrate binding site [chemical binding]; other site
293826003393	ATP binding site [chemical binding]; other site
293826003394	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
293826003395	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
293826003396	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
293826003397	tetramer interface [polypeptide binding]; other site
293826003398	TPP-binding site [chemical binding]; other site
293826003399	heterodimer interface [polypeptide binding]; other site
293826003400	phosphorylation loop region [posttranslational modification]
293826003401	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
293826003402	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
293826003403	alpha subunit interface [polypeptide binding]; other site
293826003404	TPP binding site [chemical binding]; other site
293826003405	heterodimer interface [polypeptide binding]; other site
293826003406	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
293826003407	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
293826003408	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
293826003409	E3 interaction surface; other site
293826003410	lipoyl attachment site [posttranslational modification]; other site
293826003411	e3 binding domain; Region: E3_binding; pfam02817
293826003412	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
293826003413	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
293826003414	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
293826003415	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
293826003416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
293826003417	active site
293826003418	phosphorylation site [posttranslational modification]
293826003419	intermolecular recognition site; other site
293826003420	dimerization interface [polypeptide binding]; other site
293826003421	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
293826003422	Cache domain; Region: Cache_1; pfam02743
293826003423	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826003424	dimerization interface [polypeptide binding]; other site
293826003425	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
293826003426	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
293826003427	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
293826003428	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826003429	Zn2+ binding site [ion binding]; other site
293826003430	Mg2+ binding site [ion binding]; other site
293826003431	CAT RNA binding domain; Region: CAT_RBD; smart01061
293826003432	PRD domain; Region: PRD; pfam00874
293826003433	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
293826003434	dimerization domain swap beta strand [polypeptide binding]; other site
293826003435	regulatory protein interface [polypeptide binding]; other site
293826003436	active site
293826003437	regulatory phosphorylation site [posttranslational modification]; other site
293826003438	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
293826003439	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
293826003440	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
293826003441	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
293826003442	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
293826003443	Transcriptional regulator [Transcription]; Region: IclR; COG1414
293826003444	Bacterial transcriptional regulator; Region: IclR; pfam01614
293826003445	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
293826003446	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
293826003447	active site
293826003448	intersubunit interface [polypeptide binding]; other site
293826003449	catalytic residue [active]
293826003450	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
293826003451	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
293826003452	substrate binding site [chemical binding]; other site
293826003453	ATP binding site [chemical binding]; other site
293826003454	Transcriptional regulators [Transcription]; Region: FadR; COG2186
293826003455	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826003456	DNA-binding site [nucleotide binding]; DNA binding site
293826003457	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
293826003458	Transcriptional regulators [Transcription]; Region: FadR; COG2186
293826003459	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826003460	DNA-binding site [nucleotide binding]; DNA binding site
293826003461	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
293826003462	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
293826003463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
293826003464	Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970
293826003465	Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129
293826003466	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
293826003467	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
293826003468	YtxH-like protein; Region: YtxH; pfam12732
293826003469	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
293826003470	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
293826003471	Uncharacterized conserved protein [Function unknown]; Region: COG0398
293826003472	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
293826003473	GAF domain; Region: GAF; pfam01590
293826003474	GAF domain; Region: GAF_2; pfam13185
293826003475	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826003476	Zn2+ binding site [ion binding]; other site
293826003477	Mg2+ binding site [ion binding]; other site
293826003478	PAS domain S-box; Region: sensory_box; TIGR00229
293826003479	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826003480	putative active site [active]
293826003481	heme pocket [chemical binding]; other site
293826003482	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826003483	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826003484	dimer interface [polypeptide binding]; other site
293826003485	phosphorylation site [posttranslational modification]
293826003486	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826003487	ATP binding site [chemical binding]; other site
293826003488	Mg2+ binding site [ion binding]; other site
293826003489	G-X-G motif; other site
293826003490	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
293826003491	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826003492	dimer interface [polypeptide binding]; other site
293826003493	conserved gate region; other site
293826003494	putative PBP binding loops; other site
293826003495	ABC-ATPase subunit interface; other site
293826003496	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
293826003497	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826003498	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826003499	dimer interface [polypeptide binding]; other site
293826003500	phosphorylation site [posttranslational modification]
293826003501	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826003502	ATP binding site [chemical binding]; other site
293826003503	Mg2+ binding site [ion binding]; other site
293826003504	G-X-G motif; other site
293826003505	Flavin Reductases; Region: FlaRed; cl00801
293826003506	Accessory gene regulator B; Region: AgrB; pfam04647
293826003507	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
293826003508	active site
293826003509	Spore germination protein; Region: Spore_permease; cl17796
293826003510	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
293826003511	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
293826003512	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
293826003513	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
293826003514	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
293826003515	catalytic residues [active]
293826003516	catalytic nucleophile [active]
293826003517	Recombinase; Region: Recombinase; pfam07508
293826003518	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
293826003519	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
293826003520	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
293826003521	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
293826003522	DctM-like transporters; Region: DctM; pfam06808
293826003523	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
293826003524	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
293826003525	glucuronate isomerase; Reviewed; Region: PRK02925
293826003526	mannonate dehydratase; Provisional; Region: PRK03906
293826003527	mannonate dehydratase; Region: uxuA; TIGR00695
293826003528	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
293826003529	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
293826003530	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
293826003531	Transcriptional regulators [Transcription]; Region: GntR; COG1802
293826003532	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826003533	DNA-binding site [nucleotide binding]; DNA binding site
293826003534	FCD domain; Region: FCD; pfam07729
293826003535	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
293826003536	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
293826003537	Walker A/P-loop; other site
293826003538	ATP binding site [chemical binding]; other site
293826003539	Q-loop/lid; other site
293826003540	ABC transporter signature motif; other site
293826003541	Walker B; other site
293826003542	D-loop; other site
293826003543	H-loop/switch region; other site
293826003544	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
293826003545	DNA-binding site [nucleotide binding]; DNA binding site
293826003546	RNA-binding motif; other site
293826003547	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
293826003548	putative active site [active]
293826003549	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
293826003550	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
293826003551	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
293826003552	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
293826003553	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
293826003554	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
293826003555	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
293826003556	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
293826003557	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
293826003558	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826003559	active site
293826003560	phosphorylation site [posttranslational modification]
293826003561	intermolecular recognition site; other site
293826003562	dimerization interface [polypeptide binding]; other site
293826003563	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
293826003564	Malic enzyme, N-terminal domain; Region: malic; pfam00390
293826003565	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
293826003566	putative NAD(P) binding site [chemical binding]; other site
293826003567	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
293826003568	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826003569	FeS/SAM binding site; other site
293826003570	Transposase [DNA replication, recombination, and repair]; Region: COG5421
293826003571	Transposase [DNA replication, recombination, and repair]; Region: COG5421
293826003572	HTH-like domain; Region: HTH_21; pfam13276
293826003573	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
293826003574	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
293826003575	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533
293826003576	homodimer interface [polypeptide binding]; other site
293826003577	metal binding site [ion binding]; metal-binding site
293826003578	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
293826003579	isocitrate dehydrogenase; Validated; Region: PRK06451
293826003580	aconitate hydratase; Validated; Region: PRK07229
293826003581	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
293826003582	substrate binding site [chemical binding]; other site
293826003583	ligand binding site [chemical binding]; other site
293826003584	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
293826003585	substrate binding site [chemical binding]; other site
293826003586	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
293826003587	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
293826003588	active site
293826003589	catalytic residues [active]
293826003590	metal binding site [ion binding]; metal-binding site
293826003591	Predicted transcriptional regulators [Transcription]; Region: COG1725
293826003592	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826003593	DNA-binding site [nucleotide binding]; DNA binding site
293826003594	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
293826003595	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
293826003596	Walker A/P-loop; other site
293826003597	ATP binding site [chemical binding]; other site
293826003598	Q-loop/lid; other site
293826003599	ABC transporter signature motif; other site
293826003600	Walker B; other site
293826003601	D-loop; other site
293826003602	H-loop/switch region; other site
293826003603	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
293826003604	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
293826003605	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
293826003606	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
293826003607	Walker A/P-loop; other site
293826003608	ATP binding site [chemical binding]; other site
293826003609	Q-loop/lid; other site
293826003610	ABC transporter signature motif; other site
293826003611	Walker B; other site
293826003612	D-loop; other site
293826003613	H-loop/switch region; other site
293826003614	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
293826003615	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826003616	dimer interface [polypeptide binding]; other site
293826003617	conserved gate region; other site
293826003618	ABC-ATPase subunit interface; other site
293826003619	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
293826003620	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
293826003621	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
293826003622	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
293826003623	molybdopterin cofactor binding site; other site
293826003624	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
293826003625	molybdopterin cofactor binding site; other site
293826003626	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
293826003627	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
293826003628	4Fe-4S binding domain; Region: Fer4; cl02805
293826003629	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
293826003630	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
293826003631	flavoprotein, HI0933 family; Region: TIGR00275
293826003632	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
293826003633	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
293826003634	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
293826003635	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
293826003636	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
293826003637	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
293826003638	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
293826003639	HlyD family secretion protein; Region: HlyD_3; pfam13437
293826003640	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
293826003641	Protein export membrane protein; Region: SecD_SecF; cl14618
293826003642	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
293826003643	Domain of unknown function DUF21; Region: DUF21; pfam01595
293826003644	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
293826003645	Transporter associated domain; Region: CorC_HlyC; smart01091
293826003646	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
293826003647	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
293826003648	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
293826003649	catalytic residue [active]
293826003650	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
293826003651	Ferritin-like domain; Region: Ferritin; pfam00210
293826003652	ferroxidase diiron center [ion binding]; other site
293826003653	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
293826003654	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
293826003655	active site
293826003656	motif I; other site
293826003657	motif II; other site
293826003658	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
293826003659	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
293826003660	L-aspartate oxidase; Provisional; Region: PRK06175
293826003661	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
293826003662	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
293826003663	substrate binding site [chemical binding]; other site
293826003664	ATP binding site [chemical binding]; other site
293826003665	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
293826003666	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
293826003667	putative active site [active]
293826003668	putative metal binding site [ion binding]; other site
293826003669	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
293826003670	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
293826003671	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
293826003672	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
293826003673	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
293826003674	lipoyl attachment site [posttranslational modification]; other site
293826003675	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
293826003676	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
293826003677	tetramer interface [polypeptide binding]; other site
293826003678	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826003679	catalytic residue [active]
293826003680	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
293826003681	tetramer interface [polypeptide binding]; other site
293826003682	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826003683	catalytic residue [active]
293826003684	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
293826003685	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
293826003686	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
293826003687	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
293826003688	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
293826003689	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
293826003690	Hemerythrin-like domain; Region: Hr-like; cd12108
293826003691	Fe binding site [ion binding]; other site
293826003692	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
293826003693	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
293826003694	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
293826003695	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
293826003696	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
293826003697	MgtE intracellular N domain; Region: MgtE_N; smart00924
293826003698	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
293826003699	Divalent cation transporter; Region: MgtE; pfam01769
293826003700	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
293826003701	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
293826003702	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
293826003703	germination protein YpeB; Region: spore_YpeB; TIGR02889
293826003704	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
293826003705	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
293826003706	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
293826003707	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
293826003708	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
293826003709	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
293826003710	4Fe-4S binding domain; Region: Fer4; cl02805
293826003711	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
293826003712	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
293826003713	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
293826003714	active site
293826003715	dimer interface [polypeptide binding]; other site
293826003716	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
293826003717	dimer interface [polypeptide binding]; other site
293826003718	active site
293826003719	glutamate racemase; Provisional; Region: PRK00865
293826003720	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
293826003721	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
293826003722	GAF domain; Region: GAF; cl17456
293826003723	Histidine kinase; Region: His_kinase; pfam06580
293826003724	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826003725	ATP binding site [chemical binding]; other site
293826003726	Mg2+ binding site [ion binding]; other site
293826003727	G-X-G motif; other site
293826003728	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
293826003729	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826003730	active site
293826003731	phosphorylation site [posttranslational modification]
293826003732	intermolecular recognition site; other site
293826003733	dimerization interface [polypeptide binding]; other site
293826003734	LytTr DNA-binding domain; Region: LytTR; smart00850
293826003735	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
293826003736	Carbon starvation protein CstA; Region: CstA; pfam02554
293826003737	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
293826003738	Domain of unknown function DUF77; Region: DUF77; cl00307
293826003739	hypothetical protein; Provisional; Region: PRK07205
293826003740	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
293826003741	active site
293826003742	metal binding site [ion binding]; metal-binding site
293826003743	stage V sporulation protein B; Region: spore_V_B; TIGR02900
293826003744	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
293826003745	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
293826003746	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
293826003747	ATP cone domain; Region: ATP-cone; pfam03477
293826003748	Class III ribonucleotide reductase; Region: RNR_III; cd01675
293826003749	effector binding site; other site
293826003750	active site
293826003751	Zn binding site [ion binding]; other site
293826003752	glycine loop; other site
293826003753	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
293826003754	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826003755	FeS/SAM binding site; other site
293826003756	Protein of unknown function, DUF606; Region: DUF606; pfam04657
293826003757	Protein of unknown function, DUF606; Region: DUF606; pfam04657
293826003758	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
293826003759	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
293826003760	ligand binding site [chemical binding]; other site
293826003761	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
293826003762	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
293826003763	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
293826003764	FMN-binding domain; Region: FMN_bind; cl01081
293826003765	hypothetical protein; Validated; Region: PRK07121
293826003766	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
293826003767	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
293826003768	DNA binding residues [nucleotide binding]
293826003769	dimer interface [polypeptide binding]; other site
293826003770	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
293826003771	NMT1-like family; Region: NMT1_2; pfam13379
293826003772	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
293826003773	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
293826003774	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
293826003775	active site
293826003776	HIGH motif; other site
293826003777	nucleotide binding site [chemical binding]; other site
293826003778	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
293826003779	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
293826003780	active site
293826003781	KMSKS motif; other site
293826003782	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
293826003783	tRNA binding surface [nucleotide binding]; other site
293826003784	anticodon binding site; other site
293826003785	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
293826003786	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
293826003787	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
293826003788	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
293826003789	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
293826003790	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
293826003791	integron integrase; Region: integrase_gron; TIGR02249
293826003792	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
293826003793	active site
293826003794	DNA binding site [nucleotide binding]
293826003795	Int/Topo IB signature motif; other site
293826003796	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
293826003797	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
293826003798	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
293826003799	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
293826003800	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
293826003801	catalytic residues [active]
293826003802	catalytic nucleophile [active]
293826003803	Recombinase; Region: Recombinase; pfam07508
293826003804	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
293826003805	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
293826003806	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
293826003807	putative active site [active]
293826003808	putative NTP binding site [chemical binding]; other site
293826003809	putative nucleic acid binding site [nucleotide binding]; other site
293826003810	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
293826003811	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826003812	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
293826003813	Coenzyme A binding pocket [chemical binding]; other site
293826003814	Methyltransferase domain; Region: Methyltransf_31; pfam13847
293826003815	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826003816	S-adenosylmethionine binding site [chemical binding]; other site
293826003817	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
293826003818	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
293826003819	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
293826003820	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826003821	Coenzyme A binding pocket [chemical binding]; other site
293826003822	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826003823	Coenzyme A binding pocket [chemical binding]; other site
293826003824	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
293826003825	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
293826003826	conserved cys residue [active]
293826003827	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
293826003828	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
293826003829	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
293826003830	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
293826003831	VanW like protein; Region: VanW; pfam04294
293826003832	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
293826003833	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826003834	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
293826003835	Beta-lactamase; Region: Beta-lactamase; pfam00144
293826003836	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
293826003837	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
293826003838	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
293826003839	putative deacylase active site [active]
293826003840	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
293826003841	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
293826003842	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
293826003843	putative metal binding site [ion binding]; other site
293826003844	putative acetyltransferase YhhY; Provisional; Region: PRK10140
293826003845	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826003846	Coenzyme A binding pocket [chemical binding]; other site
293826003847	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
293826003848	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
293826003849	Methyltransferase domain; Region: Methyltransf_23; pfam13489
293826003850	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826003851	S-adenosylmethionine binding site [chemical binding]; other site
293826003852	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
293826003853	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
293826003854	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
293826003855	putative acyl-acceptor binding pocket; other site
293826003856	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
293826003857	Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719
293826003858	Uncharacterized conserved protein [Function unknown]; Region: COG2461
293826003859	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
293826003860	hybrid cluster protein; Provisional; Region: PRK05290
293826003861	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
293826003862	ACS interaction site; other site
293826003863	CODH interaction site; other site
293826003864	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
293826003865	ACS interaction site; other site
293826003866	CODH interaction site; other site
293826003867	metal cluster binding site [ion binding]; other site
293826003868	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
293826003869	Ligand Binding Site [chemical binding]; other site
293826003870	PAS domain; Region: PAS_9; pfam13426
293826003871	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
293826003872	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826003873	putative active site [active]
293826003874	heme pocket [chemical binding]; other site
293826003875	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826003876	putative active site [active]
293826003877	heme pocket [chemical binding]; other site
293826003878	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826003879	PAS domain; Region: PAS_9; pfam13426
293826003880	putative active site [active]
293826003881	heme pocket [chemical binding]; other site
293826003882	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
293826003883	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
293826003884	metal binding site [ion binding]; metal-binding site
293826003885	active site
293826003886	I-site; other site
293826003887	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
293826003888	Cache domain; Region: Cache_1; pfam02743
293826003889	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
293826003890	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826003891	dimer interface [polypeptide binding]; other site
293826003892	putative CheW interface [polypeptide binding]; other site
293826003893	Pirin; Region: Pirin; pfam02678
293826003894	Pirin-related protein [General function prediction only]; Region: COG1741
293826003895	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
293826003896	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
293826003897	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826003898	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826003899	ABC transporter; Region: ABC_tran_2; pfam12848
293826003900	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826003901	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826003902	Coenzyme A binding pocket [chemical binding]; other site
293826003903	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
293826003904	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
293826003905	conserved cys residue [active]
293826003906	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
293826003907	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826003908	Coenzyme A binding pocket [chemical binding]; other site
293826003909	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
293826003910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826003911	active site
293826003912	phosphorylation site [posttranslational modification]
293826003913	intermolecular recognition site; other site
293826003914	dimerization interface [polypeptide binding]; other site
293826003915	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826003916	DNA binding site [nucleotide binding]
293826003917	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826003918	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826003919	ATP binding site [chemical binding]; other site
293826003920	Mg2+ binding site [ion binding]; other site
293826003921	G-X-G motif; other site
293826003922	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
293826003923	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
293826003924	Walker A/P-loop; other site
293826003925	ATP binding site [chemical binding]; other site
293826003926	Q-loop/lid; other site
293826003927	ABC transporter signature motif; other site
293826003928	Walker B; other site
293826003929	D-loop; other site
293826003930	H-loop/switch region; other site
293826003931	FtsX-like permease family; Region: FtsX; pfam02687
293826003932	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
293826003933	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
293826003934	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
293826003935	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
293826003936	DNA binding residues [nucleotide binding]
293826003937	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
293826003938	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
293826003939	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
293826003940	P loop nucleotide binding; other site
293826003941	switch II; other site
293826003942	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
293826003943	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
293826003944	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
293826003945	switch II; other site
293826003946	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
293826003947	Soluble P-type ATPase [General function prediction only]; Region: COG4087
293826003948	NAD-dependent deacetylase; Provisional; Region: PRK00481
293826003949	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
293826003950	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
293826003951	Integrase core domain; Region: rve; pfam00665
293826003952	transposase/IS protein; Provisional; Region: PRK09183
293826003953	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826003954	Walker A motif; other site
293826003955	ATP binding site [chemical binding]; other site
293826003956	Walker B motif; other site
293826003957	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
293826003958	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
293826003959	conserved cys residue [active]
293826003960	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
293826003961	MarR family; Region: MarR_2; pfam12802
293826003962	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
293826003963	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
293826003964	P loop; other site
293826003965	Nucleotide binding site [chemical binding]; other site
293826003966	DTAP/Switch II; other site
293826003967	Switch I; other site
293826003968	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
293826003969	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
293826003970	Walker A/P-loop; other site
293826003971	ATP binding site [chemical binding]; other site
293826003972	Q-loop/lid; other site
293826003973	ABC transporter signature motif; other site
293826003974	Walker B; other site
293826003975	D-loop; other site
293826003976	H-loop/switch region; other site
293826003977	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
293826003978	Amidinotransferase; Region: Amidinotransf; pfam02274
293826003979	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
293826003980	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
293826003981	active site
293826003982	metal binding site [ion binding]; metal-binding site
293826003983	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
293826003984	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
293826003985	PrcB C-terminal; Region: PrcB_C; pfam14343
293826003986	Predicted membrane protein [Function unknown]; Region: COG2311
293826003987	Protein of unknown function (DUF418); Region: DUF418; cl12135
293826003988	Protein of unknown function (DUF418); Region: DUF418; pfam04235
293826003989	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
293826003990	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
293826003991	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
293826003992	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
293826003993	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
293826003994	PrcB C-terminal; Region: PrcB_C; pfam14343
293826003995	Transposase domain (DUF772); Region: DUF772; pfam05598
293826003996	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
293826003997	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
293826003998	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
293826003999	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
293826004000	Walker A/P-loop; other site
293826004001	ATP binding site [chemical binding]; other site
293826004002	Q-loop/lid; other site
293826004003	ABC transporter signature motif; other site
293826004004	Walker B; other site
293826004005	D-loop; other site
293826004006	H-loop/switch region; other site
293826004007	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
293826004008	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
293826004009	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
293826004010	EcsC protein family; Region: EcsC; pfam12787
293826004011	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
293826004012	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826004013	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
293826004014	Domain of unknown function (DUF4342); Region: DUF4342; pfam14242
293826004015	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826004016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826004017	active site
293826004018	phosphorylation site [posttranslational modification]
293826004019	intermolecular recognition site; other site
293826004020	dimerization interface [polypeptide binding]; other site
293826004021	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826004022	DNA binding site [nucleotide binding]
293826004023	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826004024	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826004025	dimerization interface [polypeptide binding]; other site
293826004026	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826004027	dimer interface [polypeptide binding]; other site
293826004028	phosphorylation site [posttranslational modification]
293826004029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826004030	ATP binding site [chemical binding]; other site
293826004031	Mg2+ binding site [ion binding]; other site
293826004032	G-X-G motif; other site
293826004033	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
293826004034	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
293826004035	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258
293826004036	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
293826004037	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
293826004038	CoA binding domain; Region: CoA_binding; pfam02629
293826004039	Methyltransferase domain; Region: Methyltransf_31; pfam13847
293826004040	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826004041	S-adenosylmethionine binding site [chemical binding]; other site
293826004042	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
293826004043	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_21; cd08520
293826004044	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
293826004045	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826004046	dimer interface [polypeptide binding]; other site
293826004047	conserved gate region; other site
293826004048	putative PBP binding loops; other site
293826004049	ABC-ATPase subunit interface; other site
293826004050	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
293826004051	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826004052	dimer interface [polypeptide binding]; other site
293826004053	conserved gate region; other site
293826004054	putative PBP binding loops; other site
293826004055	ABC-ATPase subunit interface; other site
293826004056	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
293826004057	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826004058	Walker A/P-loop; other site
293826004059	ATP binding site [chemical binding]; other site
293826004060	Q-loop/lid; other site
293826004061	ABC transporter signature motif; other site
293826004062	Walker B; other site
293826004063	D-loop; other site
293826004064	H-loop/switch region; other site
293826004065	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
293826004066	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826004067	Walker A/P-loop; other site
293826004068	ATP binding site [chemical binding]; other site
293826004069	Q-loop/lid; other site
293826004070	ABC transporter signature motif; other site
293826004071	Walker B; other site
293826004072	D-loop; other site
293826004073	H-loop/switch region; other site
293826004074	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826004075	Coenzyme A binding pocket [chemical binding]; other site
293826004076	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
293826004077	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826004078	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826004079	active site
293826004080	phosphorylation site [posttranslational modification]
293826004081	intermolecular recognition site; other site
293826004082	dimerization interface [polypeptide binding]; other site
293826004083	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826004084	DNA binding site [nucleotide binding]
293826004085	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826004086	dimer interface [polypeptide binding]; other site
293826004087	phosphorylation site [posttranslational modification]
293826004088	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826004089	ATP binding site [chemical binding]; other site
293826004090	Mg2+ binding site [ion binding]; other site
293826004091	G-X-G motif; other site
293826004092	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
293826004093	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
293826004094	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
293826004095	HlyD family secretion protein; Region: HlyD_3; pfam13437
293826004096	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
293826004097	Protein export membrane protein; Region: SecD_SecF; cl14618
293826004098	Transposase; Region: DEDD_Tnp_IS110; pfam01548
293826004099	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
293826004100	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
293826004101	phosphoenolpyruvate synthase; Validated; Region: PRK06241
293826004102	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
293826004103	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
293826004104	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
293826004105	DDE superfamily endonuclease; Region: DDE_5; cl17874
293826004106	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
293826004107	Transposase; Region: DDE_Tnp_ISL3; pfam01610
293826004108	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
293826004109	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
293826004110	active site
293826004111	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
293826004112	DDE superfamily endonuclease; Region: DDE_5; cl17874
293826004113	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
293826004114	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
293826004115	Ca2+ binding site [ion binding]; other site
293826004116	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
293826004117	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
293826004118	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
293826004119	S-layer homology domain; Region: SLH; pfam00395
293826004120	S-layer homology domain; Region: SLH; pfam00395
293826004121	DDE superfamily endonuclease; Region: DDE_5; cl17874
293826004122	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826004123	DDE superfamily endonuclease; Region: DDE_5; cl17874
293826004124	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
293826004125	putative deacylase active site [active]
293826004126	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
293826004127	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826004128	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
293826004129	Walker A/P-loop; other site
293826004130	ATP binding site [chemical binding]; other site
293826004131	Q-loop/lid; other site
293826004132	ABC transporter signature motif; other site
293826004133	Walker B; other site
293826004134	D-loop; other site
293826004135	H-loop/switch region; other site
293826004136	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
293826004137	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826004138	DNA-binding site [nucleotide binding]; DNA binding site
293826004139	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
293826004140	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
293826004141	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826004142	homodimer interface [polypeptide binding]; other site
293826004143	catalytic residue [active]
293826004144	Protein of unknown function (DUF2000); Region: DUF2000; pfam09391
293826004145	FMN-binding domain; Region: FMN_bind; cl01081
293826004146	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
293826004147	L-aspartate oxidase; Provisional; Region: PRK06175
293826004148	Predicted oxidoreductase [General function prediction only]; Region: COG3573
293826004149	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
293826004150	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
293826004151	DNA binding residues [nucleotide binding]
293826004152	dimer interface [polypeptide binding]; other site
293826004153	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
293826004154	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826004155	Walker A/P-loop; other site
293826004156	ATP binding site [chemical binding]; other site
293826004157	Q-loop/lid; other site
293826004158	ABC transporter signature motif; other site
293826004159	Walker B; other site
293826004160	D-loop; other site
293826004161	H-loop/switch region; other site
293826004162	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826004163	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
293826004164	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
293826004165	FtsX-like permease family; Region: FtsX; pfam02687
293826004166	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
293826004167	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
293826004168	Walker A/P-loop; other site
293826004169	ATP binding site [chemical binding]; other site
293826004170	Q-loop/lid; other site
293826004171	ABC transporter signature motif; other site
293826004172	Walker B; other site
293826004173	D-loop; other site
293826004174	H-loop/switch region; other site
293826004175	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
293826004176	HlyD family secretion protein; Region: HlyD_3; pfam13437
293826004177	Histidine kinase; Region: HisKA_3; pfam07730
293826004178	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
293826004179	ATP binding site [chemical binding]; other site
293826004180	Mg2+ binding site [ion binding]; other site
293826004181	G-X-G motif; other site
293826004182	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
293826004183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826004184	active site
293826004185	phosphorylation site [posttranslational modification]
293826004186	intermolecular recognition site; other site
293826004187	dimerization interface [polypeptide binding]; other site
293826004188	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
293826004189	DNA binding residues [nucleotide binding]
293826004190	dimerization interface [polypeptide binding]; other site
293826004191	Predicted membrane protein [Function unknown]; Region: COG2311
293826004192	Protein of unknown function (DUF418); Region: DUF418; cl12135
293826004193	Protein of unknown function (DUF418); Region: DUF418; pfam04235
293826004194	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
293826004195	Beta-lactamase; Region: Beta-lactamase; pfam00144
293826004196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
293826004197	Nucleoside recognition; Region: Gate; pfam07670
293826004198	Predicted transcriptional regulators [Transcription]; Region: COG1695
293826004199	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
293826004200	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
293826004201	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
293826004202	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
293826004203	dimer interface [polypeptide binding]; other site
293826004204	active site
293826004205	heme binding site [chemical binding]; other site
293826004206	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
293826004207	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
293826004208	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
293826004209	metal binding site [ion binding]; metal-binding site
293826004210	active site
293826004211	I-site; other site
293826004212	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
293826004213	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826004214	non-specific DNA binding site [nucleotide binding]; other site
293826004215	salt bridge; other site
293826004216	sequence-specific DNA binding site [nucleotide binding]; other site
293826004217	Cache domain; Region: Cache_1; pfam02743
293826004218	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
293826004219	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826004220	dimer interface [polypeptide binding]; other site
293826004221	putative CheW interface [polypeptide binding]; other site
293826004222	Protein of unknown function (DUF4243); Region: DUF4243; pfam14027
293826004223	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
293826004224	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
293826004225	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
293826004226	Zn binding site [ion binding]; other site
293826004227	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
293826004228	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
293826004229	Zn binding site [ion binding]; other site
293826004230	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
293826004231	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826004232	non-specific DNA binding site [nucleotide binding]; other site
293826004233	salt bridge; other site
293826004234	sequence-specific DNA binding site [nucleotide binding]; other site
293826004235	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
293826004236	Catalytic site [active]
293826004237	DDE superfamily endonuclease; Region: DDE_5; cl17874
293826004238	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
293826004239	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
293826004240	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
293826004241	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
293826004242	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826004243	active site
293826004244	phosphorylation site [posttranslational modification]
293826004245	intermolecular recognition site; other site
293826004246	dimerization interface [polypeptide binding]; other site
293826004247	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
293826004248	DNA binding residues [nucleotide binding]
293826004249	dimerization interface [polypeptide binding]; other site
293826004250	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
293826004251	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
293826004252	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
293826004253	Walker A/P-loop; other site
293826004254	ATP binding site [chemical binding]; other site
293826004255	Q-loop/lid; other site
293826004256	ABC transporter signature motif; other site
293826004257	Walker B; other site
293826004258	D-loop; other site
293826004259	H-loop/switch region; other site
293826004260	Predicted transcriptional regulators [Transcription]; Region: COG1695
293826004261	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
293826004262	Chromate transporter; Region: Chromate_transp; pfam02417
293826004263	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
293826004264	Chromate transporter; Region: Chromate_transp; pfam02417
293826004265	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
293826004266	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
293826004267	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
293826004268	Domain of unknown function (DUF4364); Region: DUF4364; pfam14277
293826004269	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
293826004270	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
293826004271	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
293826004272	active site
293826004273	DNA binding site [nucleotide binding]
293826004274	Int/Topo IB signature motif; other site
293826004275	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
293826004276	active site
293826004277	DNA binding site [nucleotide binding]
293826004278	Int/Topo IB signature motif; other site
293826004279	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
293826004280	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
293826004281	active site
293826004282	catalytic residues [active]
293826004283	DNA binding site [nucleotide binding]
293826004284	Int/Topo IB signature motif; other site
293826004285	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
293826004286	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826004287	non-specific DNA binding site [nucleotide binding]; other site
293826004288	salt bridge; other site
293826004289	sequence-specific DNA binding site [nucleotide binding]; other site
293826004290	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
293826004291	ATP binding site [chemical binding]; other site
293826004292	Mg2+ binding site [ion binding]; other site
293826004293	G-X-G motif; other site
293826004294	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
293826004295	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
293826004296	putative active site [active]
293826004297	putative NTP binding site [chemical binding]; other site
293826004298	putative nucleic acid binding site [nucleotide binding]; other site
293826004299	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
293826004300	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
293826004301	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
293826004302	catalytic residues [active]
293826004303	catalytic nucleophile [active]
293826004304	Recombinase; Region: Recombinase; pfam07508
293826004305	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
293826004306	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
293826004307	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
293826004308	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
293826004309	HTH-like domain; Region: HTH_21; pfam13276
293826004310	Integrase core domain; Region: rve; pfam00665
293826004311	HsdM N-terminal domain; Region: HsdM_N; pfam12161
293826004312	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
293826004313	Methyltransferase domain; Region: Methyltransf_26; pfam13659
293826004314	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
293826004315	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
293826004316	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
293826004317	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
293826004318	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
293826004319	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
293826004320	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
293826004321	ATP binding site [chemical binding]; other site
293826004322	putative Mg++ binding site [ion binding]; other site
293826004323	Divergent AAA domain; Region: AAA_4; pfam04326
293826004324	Caspase domain; Region: Peptidase_C14; pfam00656
293826004325	Transposase, Mutator family; Region: Transposase_mut; pfam00872
293826004326	MULE transposase domain; Region: MULE; pfam10551
293826004327	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
293826004328	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
293826004329	Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u3_5s; cd10972
293826004330	putative active site [active]
293826004331	putative metal binding site [ion binding]; other site
293826004332	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
293826004333	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
293826004334	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
293826004335	aspartate aminotransferase; Provisional; Region: PRK06290
293826004336	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
293826004337	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826004338	homodimer interface [polypeptide binding]; other site
293826004339	catalytic residue [active]
293826004340	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
293826004341	NodB motif; other site
293826004342	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
293826004343	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
293826004344	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
293826004345	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
293826004346	single-stranded DNA-binding protein; Provisional; Region: PRK05813
293826004347	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
293826004348	dimer interface [polypeptide binding]; other site
293826004349	ssDNA binding site [nucleotide binding]; other site
293826004350	tetramer (dimer of dimers) interface [polypeptide binding]; other site
293826004351	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
293826004352	GAF domain; Region: GAF_2; pfam13185
293826004353	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
293826004354	active site
293826004355	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
293826004356	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
293826004357	metal binding site [ion binding]; metal-binding site
293826004358	dimer interface [polypeptide binding]; other site
293826004359	CAAX protease self-immunity; Region: Abi; pfam02517
293826004360	Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129
293826004361	putative active site [active]
293826004362	putative catalytic site [active]
293826004363	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130
293826004364	PLD-like domain; Region: PLDc_2; pfam13091
293826004365	putative active site [active]
293826004366	putative catalytic site [active]
293826004367	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
293826004368	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826004369	S-adenosylmethionine binding site [chemical binding]; other site
293826004370	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
293826004371	DNA-binding site [nucleotide binding]; DNA binding site
293826004372	RNA-binding motif; other site
293826004373	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
293826004374	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
293826004375	dimerization interface [polypeptide binding]; other site
293826004376	domain crossover interface; other site
293826004377	redox-dependent activation switch; other site
293826004378	YtxC-like family; Region: YtxC; pfam08812
293826004379	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
293826004380	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
293826004381	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
293826004382	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
293826004383	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
293826004384	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
293826004385	active site
293826004386	dimer interface [polypeptide binding]; other site
293826004387	motif 1; other site
293826004388	motif 2; other site
293826004389	motif 3; other site
293826004390	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
293826004391	anticodon binding site; other site
293826004392	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826004393	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
293826004394	Walker A motif; other site
293826004395	ATP binding site [chemical binding]; other site
293826004396	Walker B motif; other site
293826004397	arginine finger; other site
293826004398	Peptidase family M41; Region: Peptidase_M41; pfam01434
293826004399	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
293826004400	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
293826004401	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
293826004402	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
293826004403	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
293826004404	23S rRNA binding site [nucleotide binding]; other site
293826004405	L21 binding site [polypeptide binding]; other site
293826004406	L13 binding site [polypeptide binding]; other site
293826004407	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
293826004408	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
293826004409	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
293826004410	TrkA-N domain; Region: TrkA_N; pfam02254
293826004411	TrkA-C domain; Region: TrkA_C; pfam02080
293826004412	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
293826004413	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
293826004414	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
293826004415	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
293826004416	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
293826004417	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
293826004418	dimer interface [polypeptide binding]; other site
293826004419	motif 1; other site
293826004420	active site
293826004421	motif 2; other site
293826004422	motif 3; other site
293826004423	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
293826004424	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
293826004425	putative tRNA-binding site [nucleotide binding]; other site
293826004426	B3/4 domain; Region: B3_4; pfam03483
293826004427	tRNA synthetase B5 domain; Region: B5; smart00874
293826004428	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
293826004429	dimer interface [polypeptide binding]; other site
293826004430	motif 1; other site
293826004431	motif 3; other site
293826004432	motif 2; other site
293826004433	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
293826004434	Cell division protein ZapA; Region: ZapA; pfam05164
293826004435	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
293826004436	Peptidase family U32; Region: Peptidase_U32; pfam01136
293826004437	Collagenase; Region: DUF3656; pfam12392
293826004438	Peptidase family U32; Region: Peptidase_U32; pfam01136
293826004439	manganese transport transcriptional regulator; Provisional; Region: PRK03902
293826004440	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
293826004441	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
293826004442	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
293826004443	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
293826004444	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
293826004445	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
293826004446	ABC-ATPase subunit  interface; other site
293826004447	dimer interface [polypeptide binding]; other site
293826004448	putative PBP binding regions; other site
293826004449	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
293826004450	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
293826004451	intersubunit interface [polypeptide binding]; other site
293826004452	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
293826004453	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
293826004454	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842
293826004455	dimer interface [polypeptide binding]; other site
293826004456	active site
293826004457	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
293826004458	catalytic residues [active]
293826004459	substrate binding site [chemical binding]; other site
293826004460	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
293826004461	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
293826004462	dimer interface [polypeptide binding]; other site
293826004463	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826004464	catalytic residue [active]
293826004465	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
293826004466	active site residue [active]
293826004467	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
293826004468	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
293826004469	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
293826004470	catalytic residue [active]
293826004471	cobalt transport protein CbiM; Validated; Region: PRK06265
293826004472	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
293826004473	Cobalt transport protein; Region: CbiQ; cl00463
293826004474	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13652
293826004475	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
293826004476	Walker A/P-loop; other site
293826004477	ATP binding site [chemical binding]; other site
293826004478	Q-loop/lid; other site
293826004479	ABC transporter signature motif; other site
293826004480	Walker B; other site
293826004481	D-loop; other site
293826004482	H-loop/switch region; other site
293826004483	Uncharacterized conserved protein [Function unknown]; Region: COG0398
293826004484	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
293826004485	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
293826004486	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
293826004487	GIY-YIG motif/motif A; other site
293826004488	putative active site [active]
293826004489	putative metal binding site [ion binding]; other site
293826004490	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
293826004491	putative alcohol dehydrogenase; Provisional; Region: PRK09860
293826004492	dimer interface [polypeptide binding]; other site
293826004493	active site
293826004494	metal binding site [ion binding]; metal-binding site
293826004495	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
293826004496	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
293826004497	putative FMN binding site [chemical binding]; other site
293826004498	NADPH bind site [chemical binding]; other site
293826004499	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
293826004500	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
293826004501	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
293826004502	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
293826004503	dimer interface [polypeptide binding]; other site
293826004504	PYR/PP interface [polypeptide binding]; other site
293826004505	TPP binding site [chemical binding]; other site
293826004506	substrate binding site [chemical binding]; other site
293826004507	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
293826004508	TPP-binding site; other site
293826004509	4Fe-4S binding domain; Region: Fer4; pfam00037
293826004510	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
293826004511	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
293826004512	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
293826004513	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
293826004514	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
293826004515	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
293826004516	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
293826004517	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
293826004518	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
293826004519	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
293826004520	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
293826004521	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
293826004522	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
293826004523	NAD(P) binding site [chemical binding]; other site
293826004524	substrate binding site [chemical binding]; other site
293826004525	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
293826004526	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
293826004527	active site
293826004528	nucleotide binding site [chemical binding]; other site
293826004529	HIGH motif; other site
293826004530	KMSKS motif; other site
293826004531	RDD family; Region: RDD; pfam06271
293826004532	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
293826004533	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
293826004534	substrate binding pocket [chemical binding]; other site
293826004535	membrane-bound complex binding site; other site
293826004536	hinge residues; other site
293826004537	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826004538	dimer interface [polypeptide binding]; other site
293826004539	conserved gate region; other site
293826004540	putative PBP binding loops; other site
293826004541	ABC-ATPase subunit interface; other site
293826004542	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
293826004543	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
293826004544	Walker A/P-loop; other site
293826004545	ATP binding site [chemical binding]; other site
293826004546	Q-loop/lid; other site
293826004547	ABC transporter signature motif; other site
293826004548	Walker B; other site
293826004549	D-loop; other site
293826004550	H-loop/switch region; other site
293826004551	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
293826004552	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
293826004553	dimer interface [polypeptide binding]; other site
293826004554	PYR/PP interface [polypeptide binding]; other site
293826004555	TPP binding site [chemical binding]; other site
293826004556	substrate binding site [chemical binding]; other site
293826004557	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
293826004558	Domain of unknown function; Region: EKR; smart00890
293826004559	4Fe-4S binding domain; Region: Fer4_6; pfam12837
293826004560	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
293826004561	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
293826004562	TPP-binding site [chemical binding]; other site
293826004563	dimer interface [polypeptide binding]; other site
293826004564	4-alpha-glucanotransferase; Provisional; Region: PRK14508
293826004565	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
293826004566	homodimer interface [polypeptide binding]; other site
293826004567	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
293826004568	active site pocket [active]
293826004569	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
293826004570	putative active site [active]
293826004571	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
293826004572	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
293826004573	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826004574	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826004575	DNA binding residues [nucleotide binding]
293826004576	Domain of unknown function (DUF3787); Region: DUF3787; pfam12655
293826004577	Permease family; Region: Xan_ur_permease; pfam00860
293826004578	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
293826004579	Transposase IS200 like; Region: Y1_Tnp; cl00848
293826004580	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
293826004581	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
293826004582	Walker A/P-loop; other site
293826004583	ATP binding site [chemical binding]; other site
293826004584	Q-loop/lid; other site
293826004585	ABC transporter signature motif; other site
293826004586	Walker B; other site
293826004587	D-loop; other site
293826004588	H-loop/switch region; other site
293826004589	FtsX-like permease family; Region: FtsX; pfam02687
293826004590	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
293826004591	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826004592	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826004593	active site
293826004594	phosphorylation site [posttranslational modification]
293826004595	intermolecular recognition site; other site
293826004596	dimerization interface [polypeptide binding]; other site
293826004597	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826004598	DNA binding site [nucleotide binding]
293826004599	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826004600	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826004601	dimer interface [polypeptide binding]; other site
293826004602	phosphorylation site [posttranslational modification]
293826004603	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826004604	ATP binding site [chemical binding]; other site
293826004605	Mg2+ binding site [ion binding]; other site
293826004606	G-X-G motif; other site
293826004607	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
293826004608	Uncharacterized conserved protein [Function unknown]; Region: COG2006
293826004609	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
293826004610	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
293826004611	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
293826004612	putative active site [active]
293826004613	putative metal binding site [ion binding]; other site
293826004614	Domain of unknown function (DUF1874); Region: DUF1874; pfam08960
293826004615	metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921
293826004616	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
293826004617	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
293826004618	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
293826004619	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
293826004620	Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916
293826004621	Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289
293826004622	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
293826004623	putative NADP binding site [chemical binding]; other site
293826004624	putative dimer interface [polypeptide binding]; other site
293826004625	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
293826004626	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
293826004627	Peptidase M16C associated; Region: M16C_assoc; pfam08367
293826004628	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
293826004629	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
293826004630	DRTGG domain; Region: DRTGG; pfam07085
293826004631	CBS domain; Region: CBS; pfam00571
293826004632	DHHA2 domain; Region: DHHA2; pfam02833
293826004633	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532
293826004634	metal binding site [ion binding]; metal-binding site
293826004635	competence damage-inducible protein A; Provisional; Region: PRK00549
293826004636	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
293826004637	putative MPT binding site; other site
293826004638	Competence-damaged protein; Region: CinA; pfam02464
293826004639	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
293826004640	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826004641	Zn2+ binding site [ion binding]; other site
293826004642	Mg2+ binding site [ion binding]; other site
293826004643	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
293826004644	L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272
293826004645	NAD binding site [chemical binding]; other site
293826004646	homodimer interface [polypeptide binding]; other site
293826004647	active site
293826004648	putative substrate binding site [chemical binding]; other site
293826004649	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
293826004650	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
293826004651	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
293826004652	RNA binding surface [nucleotide binding]; other site
293826004653	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
293826004654	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
293826004655	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
293826004656	catalytic residue [active]
293826004657	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
293826004658	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
293826004659	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
293826004660	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
293826004661	G1 box; other site
293826004662	putative GEF interaction site [polypeptide binding]; other site
293826004663	GTP/Mg2+ binding site [chemical binding]; other site
293826004664	Switch I region; other site
293826004665	G2 box; other site
293826004666	G3 box; other site
293826004667	Switch II region; other site
293826004668	G4 box; other site
293826004669	G5 box; other site
293826004670	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
293826004671	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
293826004672	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
293826004673	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
293826004674	NodB motif; other site
293826004675	active site
293826004676	catalytic site [active]
293826004677	Zn binding site [ion binding]; other site
293826004678	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
293826004679	MutS domain III; Region: MutS_III; pfam05192
293826004680	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
293826004681	Walker A/P-loop; other site
293826004682	ATP binding site [chemical binding]; other site
293826004683	Q-loop/lid; other site
293826004684	ABC transporter signature motif; other site
293826004685	Walker B; other site
293826004686	D-loop; other site
293826004687	H-loop/switch region; other site
293826004688	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
293826004689	Smr domain; Region: Smr; pfam01713
293826004690	Uncharacterized conserved protein [Function unknown]; Region: COG1683
293826004691	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
293826004692	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
293826004693	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
293826004694	active site
293826004695	HIGH motif; other site
293826004696	KMSK motif region; other site
293826004697	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
293826004698	tRNA binding surface [nucleotide binding]; other site
293826004699	anticodon binding site; other site
293826004700	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826004701	dimer interface [polypeptide binding]; other site
293826004702	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
293826004703	putative CheW interface [polypeptide binding]; other site
293826004704	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
293826004705	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
293826004706	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
293826004707	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
293826004708	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
293826004709	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
293826004710	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
293826004711	Radical SAM superfamily; Region: Radical_SAM; pfam04055
293826004712	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826004713	FeS/SAM binding site; other site
293826004714	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
293826004715	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
293826004716	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826004717	Coenzyme A binding pocket [chemical binding]; other site
293826004718	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826004719	binding surface
293826004720	TPR motif; other site
293826004721	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826004722	binding surface
293826004723	TPR repeat; Region: TPR_11; pfam13414
293826004724	TPR motif; other site
293826004725	TPR repeat; Region: TPR_11; pfam13414
293826004726	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
293826004727	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826004728	S-adenosylmethionine binding site [chemical binding]; other site
293826004729	Helix-turn-helix domain; Region: HTH_17; pfam12728
293826004730	Protein of unknown function (DUF523); Region: DUF523; cl00733
293826004731	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
293826004732	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
293826004733	active site
293826004734	metal binding site [ion binding]; metal-binding site
293826004735	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
293826004736	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
293826004737	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826004738	Walker A/P-loop; other site
293826004739	ATP binding site [chemical binding]; other site
293826004740	Q-loop/lid; other site
293826004741	ABC transporter signature motif; other site
293826004742	Walker B; other site
293826004743	D-loop; other site
293826004744	H-loop/switch region; other site
293826004745	TOBE domain; Region: TOBE_2; pfam08402
293826004746	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
293826004747	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826004748	dimer interface [polypeptide binding]; other site
293826004749	conserved gate region; other site
293826004750	putative PBP binding loops; other site
293826004751	ABC-ATPase subunit interface; other site
293826004752	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
293826004753	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826004754	dimer interface [polypeptide binding]; other site
293826004755	conserved gate region; other site
293826004756	putative PBP binding loops; other site
293826004757	ABC-ATPase subunit interface; other site
293826004758	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
293826004759	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
293826004760	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
293826004761	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
293826004762	RNase E interface [polypeptide binding]; other site
293826004763	trimer interface [polypeptide binding]; other site
293826004764	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
293826004765	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
293826004766	RNase E interface [polypeptide binding]; other site
293826004767	trimer interface [polypeptide binding]; other site
293826004768	active site
293826004769	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
293826004770	putative nucleic acid binding region [nucleotide binding]; other site
293826004771	G-X-X-G motif; other site
293826004772	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
293826004773	RNA binding site [nucleotide binding]; other site
293826004774	domain interface; other site
293826004775	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
293826004776	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
293826004777	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
293826004778	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
293826004779	Transposase domain (DUF772); Region: DUF772; pfam05598
293826004780	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
293826004781	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
293826004782	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
293826004783	metal ion-dependent adhesion site (MIDAS); other site
293826004784	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
293826004785	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
293826004786	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
293826004787	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826004788	Walker A motif; other site
293826004789	ATP binding site [chemical binding]; other site
293826004790	Walker B motif; other site
293826004791	Helix-turn-helix domain; Region: HTH_38; pfam13936
293826004792	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
293826004793	Integrase core domain; Region: rve; pfam00665
293826004794	Methyltransferase domain; Region: Methyltransf_31; pfam13847
293826004795	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826004796	S-adenosylmethionine binding site [chemical binding]; other site
293826004797	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
293826004798	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
293826004799	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
293826004800	Integrase core domain; Region: rve; pfam00665
293826004801	transposase/IS protein; Provisional; Region: PRK09183
293826004802	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826004803	Walker A motif; other site
293826004804	ATP binding site [chemical binding]; other site
293826004805	Walker B motif; other site
293826004806	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
293826004807	DNA binding site [nucleotide binding]
293826004808	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826004809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826004810	active site
293826004811	phosphorylation site [posttranslational modification]
293826004812	intermolecular recognition site; other site
293826004813	dimerization interface [polypeptide binding]; other site
293826004814	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826004815	DNA binding site [nucleotide binding]
293826004816	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
293826004817	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826004818	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826004819	dimer interface [polypeptide binding]; other site
293826004820	phosphorylation site [posttranslational modification]
293826004821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826004822	ATP binding site [chemical binding]; other site
293826004823	Mg2+ binding site [ion binding]; other site
293826004824	G-X-G motif; other site
293826004825	FlaG protein; Region: FlaG; pfam03646
293826004826	legume lectins; Region: lectin_L-type; cd01951
293826004827	homotetramer interaction site [polypeptide binding]; other site
293826004828	carbohydrate binding site [chemical binding]; other site
293826004829	metal binding site [ion binding]; metal-binding site
293826004830	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
293826004831	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
293826004832	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
293826004833	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
293826004834	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
293826004835	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
293826004836	S-layer homology domain; Region: SLH; pfam00395
293826004837	S-layer homology domain; Region: SLH; pfam00395
293826004838	EamA-like transporter family; Region: EamA; pfam00892
293826004839	EamA-like transporter family; Region: EamA; pfam00892
293826004840	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
293826004841	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
293826004842	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
293826004843	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
293826004844	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
293826004845	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
293826004846	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
293826004847	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
293826004848	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
293826004849	putative active site [active]
293826004850	putative metal binding site [ion binding]; other site
293826004851	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
293826004852	S-adenosylmethionine binding site [chemical binding]; other site
293826004853	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
293826004854	DEAD-like helicases superfamily; Region: DEXDc; smart00487
293826004855	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
293826004856	ATP binding site [chemical binding]; other site
293826004857	putative Mg++ binding site [ion binding]; other site
293826004858	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
293826004859	nucleotide binding region [chemical binding]; other site
293826004860	ATP-binding site [chemical binding]; other site
293826004861	C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126
293826004862	DDE superfamily endonuclease; Region: DDE_3; pfam13358
293826004863	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
293826004864	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
293826004865	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
293826004866	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826004867	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826004868	DNA binding residues [nucleotide binding]
293826004869	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
293826004870	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
293826004871	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826004872	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826004873	DNA binding residues [nucleotide binding]
293826004874	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
293826004875	Peptidase family M48; Region: Peptidase_M48; cl12018
293826004876	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
293826004877	Peptidase family M23; Region: Peptidase_M23; pfam01551
293826004878	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
293826004879	cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104
293826004880	Domain of unknown function (DUF4181); Region: DUF4181; pfam13789
293826004881	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
293826004882	dimerization interface [polypeptide binding]; other site
293826004883	putative DNA binding site [nucleotide binding]; other site
293826004884	putative Zn2+ binding site [ion binding]; other site
293826004885	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
293826004886	Sodium Bile acid symporter family; Region: SBF; cl17470
293826004887	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
293826004888	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
293826004889	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
293826004890	P loop; other site
293826004891	Nucleotide binding site [chemical binding]; other site
293826004892	DTAP/Switch II; other site
293826004893	Switch I; other site
293826004894	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
293826004895	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
293826004896	P loop; other site
293826004897	Nucleotide binding site [chemical binding]; other site
293826004898	DTAP/Switch II; other site
293826004899	Switch I; other site
293826004900	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
293826004901	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
293826004902	catalytic triad [active]
293826004903	Predicted permeases [General function prediction only]; Region: COG0701
293826004904	Rdx family; Region: Rdx; cl01407
293826004905	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
293826004906	dimerization interface [polypeptide binding]; other site
293826004907	putative DNA binding site [nucleotide binding]; other site
293826004908	putative Zn2+ binding site [ion binding]; other site
293826004909	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
293826004910	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
293826004911	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
293826004912	catalytic residue [active]
293826004913	Putative Fe-S cluster; Region: FeS; cl17515
293826004914	Predicted permease; Region: DUF318; cl17795
293826004915	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
293826004916	dimerization interface [polypeptide binding]; other site
293826004917	putative DNA binding site [nucleotide binding]; other site
293826004918	putative Zn2+ binding site [ion binding]; other site
293826004919	Predicted transcriptional regulators [Transcription]; Region: COG1725
293826004920	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826004921	DNA-binding site [nucleotide binding]; DNA binding site
293826004922	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
293826004923	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
293826004924	Walker A/P-loop; other site
293826004925	ATP binding site [chemical binding]; other site
293826004926	Q-loop/lid; other site
293826004927	ABC transporter signature motif; other site
293826004928	Walker B; other site
293826004929	D-loop; other site
293826004930	H-loop/switch region; other site
293826004931	RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950
293826004932	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826004933	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826004934	DNA binding residues [nucleotide binding]
293826004935	KWG Leptospira; Region: KWG; pfam07656
293826004936	KWG Leptospira; Region: KWG; pfam07656
293826004937	cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104
293826004938	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
293826004939	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
293826004940	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
293826004941	putative FMN binding site [chemical binding]; other site
293826004942	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
293826004943	GIY-YIG motif/motif A; other site
293826004944	putative active site [active]
293826004945	putative metal binding site [ion binding]; other site
293826004946	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
293826004947	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
293826004948	putative DNA binding site [nucleotide binding]; other site
293826004949	putative Zn2+ binding site [ion binding]; other site
293826004950	hypothetical protein; Provisional; Region: PRK09272
293826004951	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
293826004952	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
293826004953	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
293826004954	putative active site [active]
293826004955	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
293826004956	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826004957	dimer interface [polypeptide binding]; other site
293826004958	conserved gate region; other site
293826004959	putative PBP binding loops; other site
293826004960	ABC-ATPase subunit interface; other site
293826004961	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
293826004962	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
293826004963	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826004964	dimer interface [polypeptide binding]; other site
293826004965	conserved gate region; other site
293826004966	putative PBP binding loops; other site
293826004967	ABC-ATPase subunit interface; other site
293826004968	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
293826004969	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826004970	Walker A/P-loop; other site
293826004971	ATP binding site [chemical binding]; other site
293826004972	Q-loop/lid; other site
293826004973	ABC transporter signature motif; other site
293826004974	Walker B; other site
293826004975	D-loop; other site
293826004976	H-loop/switch region; other site
293826004977	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
293826004978	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
293826004979	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826004980	Walker A/P-loop; other site
293826004981	ATP binding site [chemical binding]; other site
293826004982	Q-loop/lid; other site
293826004983	ABC transporter signature motif; other site
293826004984	Walker B; other site
293826004985	D-loop; other site
293826004986	H-loop/switch region; other site
293826004987	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
293826004988	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
293826004989	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
293826004990	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
293826004991	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
293826004992	active site
293826004993	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
293826004994	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
293826004995	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
293826004996	active site
293826004997	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
293826004998	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
293826004999	homodimer interface [polypeptide binding]; other site
293826005000	homotetramer interface [polypeptide binding]; other site
293826005001	active site pocket [active]
293826005002	cleavage site
293826005003	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
293826005004	Sodium Bile acid symporter family; Region: SBF; cl17470
293826005005	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
293826005006	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
293826005007	AMIN domain; Region: AMIN; pfam11741
293826005008	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
293826005009	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
293826005010	active site
293826005011	metal binding site [ion binding]; metal-binding site
293826005012	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
293826005013	Active site serine [active]
293826005014	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
293826005015	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
293826005016	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
293826005017	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
293826005018	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826005019	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
293826005020	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
293826005021	DNA binding residues [nucleotide binding]
293826005022	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
293826005023	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
293826005024	GIY-YIG motif/motif A; other site
293826005025	DinB superfamily; Region: DinB_2; pfam12867
293826005026	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
293826005027	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
293826005028	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
293826005029	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
293826005030	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826005031	Walker A motif; other site
293826005032	ATP binding site [chemical binding]; other site
293826005033	Walker B motif; other site
293826005034	arginine finger; other site
293826005035	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
293826005036	metal ion-dependent adhesion site (MIDAS); other site
293826005037	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
293826005038	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826005039	non-specific DNA binding site [nucleotide binding]; other site
293826005040	salt bridge; other site
293826005041	sequence-specific DNA binding site [nucleotide binding]; other site
293826005042	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
293826005043	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cd00524
293826005044	non-heme iron binding site [ion binding]; other site
293826005045	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
293826005046	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
293826005047	trimer interface [polypeptide binding]; other site
293826005048	active site
293826005049	substrate binding site [chemical binding]; other site
293826005050	CoA binding site [chemical binding]; other site
293826005051	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
293826005052	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826005053	ABC transporter; Region: ABC_tran_2; pfam12848
293826005054	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826005055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
293826005056	H+ Antiporter protein; Region: 2A0121; TIGR00900
293826005057	putative substrate translocation pore; other site
293826005058	Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152
293826005059	Phosphotransferase enzyme family; Region: APH; pfam01636
293826005060	putative active site [active]
293826005061	putative substrate binding site [chemical binding]; other site
293826005062	ATP binding site [chemical binding]; other site
293826005063	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
293826005064	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
293826005065	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
293826005066	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
293826005067	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
293826005068	Transposase domain (DUF772); Region: DUF772; pfam05598
293826005069	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826005070	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
293826005071	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826005072	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
293826005073	dimer interface [polypeptide binding]; other site
293826005074	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
293826005075	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
293826005076	dimer interface [polypeptide binding]; other site
293826005077	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
293826005078	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
293826005079	phosphoenolpyruvate synthase; Validated; Region: PRK06241
293826005080	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
293826005081	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
293826005082	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826005083	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826005084	active site
293826005085	phosphorylation site [posttranslational modification]
293826005086	intermolecular recognition site; other site
293826005087	dimerization interface [polypeptide binding]; other site
293826005088	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826005089	DNA binding site [nucleotide binding]
293826005090	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826005091	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826005092	dimerization interface [polypeptide binding]; other site
293826005093	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826005094	dimer interface [polypeptide binding]; other site
293826005095	phosphorylation site [posttranslational modification]
293826005096	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826005097	ATP binding site [chemical binding]; other site
293826005098	Mg2+ binding site [ion binding]; other site
293826005099	G-X-G motif; other site
293826005100	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826005101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826005102	active site
293826005103	phosphorylation site [posttranslational modification]
293826005104	intermolecular recognition site; other site
293826005105	dimerization interface [polypeptide binding]; other site
293826005106	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826005107	DNA binding site [nucleotide binding]
293826005108	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826005109	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826005110	dimerization interface [polypeptide binding]; other site
293826005111	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826005112	dimer interface [polypeptide binding]; other site
293826005113	phosphorylation site [posttranslational modification]
293826005114	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826005115	ATP binding site [chemical binding]; other site
293826005116	Mg2+ binding site [ion binding]; other site
293826005117	G-X-G motif; other site
293826005118	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
293826005119	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826005120	Walker A/P-loop; other site
293826005121	ATP binding site [chemical binding]; other site
293826005122	Q-loop/lid; other site
293826005123	ABC transporter signature motif; other site
293826005124	Walker B; other site
293826005125	D-loop; other site
293826005126	H-loop/switch region; other site
293826005127	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
293826005128	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
293826005129	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826005130	non-specific DNA binding site [nucleotide binding]; other site
293826005131	salt bridge; other site
293826005132	sequence-specific DNA binding site [nucleotide binding]; other site
293826005133	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
293826005134	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826005135	non-specific DNA binding site [nucleotide binding]; other site
293826005136	salt bridge; other site
293826005137	sequence-specific DNA binding site [nucleotide binding]; other site
293826005138	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
293826005139	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
293826005140	AAA domain; Region: AAA_22; pfam13401
293826005141	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
293826005142	Protein of unknown function (DUF1018); Region: DUF1018; cl01815
293826005143	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
293826005144	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826005145	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826005146	DNA binding residues [nucleotide binding]
293826005147	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
293826005148	3D domain; Region: 3D; cl01439
293826005149	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
293826005150	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
293826005151	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
293826005152	active site
293826005153	Bacterial SH3 domain; Region: SH3_3; cl17532
293826005154	Mor transcription activator family; Region: Mor; cl02360
293826005155	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
293826005156	transcription termination/antitermination factor NusG; Region: nusG; TIGR00922
293826005157	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000
293826005158	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
293826005159	heterodimer interface [polypeptide binding]; other site
293826005160	homodimer interface [polypeptide binding]; other site
293826005161	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
293826005162	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
293826005163	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
293826005164	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
293826005165	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
293826005166	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566
293826005167	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
293826005168	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834
293826005169	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
293826005170	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
293826005171	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
293826005172	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
293826005173	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
293826005174	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
293826005175	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900
293826005176	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
293826005177	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
293826005178	active site
293826005179	DNA binding site [nucleotide binding]
293826005180	Int/Topo IB signature motif; other site
293826005181	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
293826005182	active site
293826005183	catalytic triad [active]
293826005184	oxyanion hole [active]
293826005185	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
293826005186	DHHW protein; Region: DHHW; pfam14286
293826005187	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
293826005188	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
293826005189	active site
293826005190	metal binding site [ion binding]; metal-binding site
293826005191	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
293826005192	Predicted flavoprotein [General function prediction only]; Region: COG0431
293826005193	Cupin domain; Region: Cupin_2; pfam07883
293826005194	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
293826005195	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
293826005196	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
293826005197	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
293826005198	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826005199	FeS/SAM binding site; other site
293826005200	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
293826005201	putative metal binding site [ion binding]; other site
293826005202	Uncharacterized conserved protein [Function unknown]; Region: COG1432
293826005203	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
293826005204	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826005205	dimer interface [polypeptide binding]; other site
293826005206	phosphorylation site [posttranslational modification]
293826005207	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826005208	ATP binding site [chemical binding]; other site
293826005209	Mg2+ binding site [ion binding]; other site
293826005210	G-X-G motif; other site
293826005211	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826005212	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826005213	active site
293826005214	phosphorylation site [posttranslational modification]
293826005215	intermolecular recognition site; other site
293826005216	dimerization interface [polypeptide binding]; other site
293826005217	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826005218	DNA binding site [nucleotide binding]
293826005219	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
293826005220	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
293826005221	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
293826005222	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
293826005223	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
293826005224	CotH protein; Region: CotH; pfam08757
293826005225	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
293826005226	putative metal binding residues [ion binding]; other site
293826005227	signature motif; other site
293826005228	dimer interface [polypeptide binding]; other site
293826005229	active site
293826005230	polyP binding site; other site
293826005231	substrate binding site [chemical binding]; other site
293826005232	acceptor-phosphate pocket; other site
293826005233	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
293826005234	Leucine-rich repeats; other site
293826005235	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
293826005236	Substrate binding site [chemical binding]; other site
293826005237	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
293826005238	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
293826005239	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
293826005240	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826005241	Coenzyme A binding pocket [chemical binding]; other site
293826005242	RNA polymerase factor sigma-70; Validated; Region: PRK09047
293826005243	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826005244	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826005245	DNA binding residues [nucleotide binding]
293826005246	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
293826005247	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
293826005248	Walker A/P-loop; other site
293826005249	ATP binding site [chemical binding]; other site
293826005250	Q-loop/lid; other site
293826005251	ABC transporter signature motif; other site
293826005252	Walker B; other site
293826005253	D-loop; other site
293826005254	H-loop/switch region; other site
293826005255	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
293826005256	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
293826005257	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
293826005258	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
293826005259	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
293826005260	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826005261	dimer interface [polypeptide binding]; other site
293826005262	conserved gate region; other site
293826005263	putative PBP binding loops; other site
293826005264	ABC-ATPase subunit interface; other site
293826005265	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
293826005266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826005267	dimer interface [polypeptide binding]; other site
293826005268	conserved gate region; other site
293826005269	putative PBP binding loops; other site
293826005270	ABC-ATPase subunit interface; other site
293826005271	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
293826005272	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
293826005273	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826005274	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
293826005275	Walker A/P-loop; other site
293826005276	ATP binding site [chemical binding]; other site
293826005277	Q-loop/lid; other site
293826005278	ABC transporter signature motif; other site
293826005279	Walker B; other site
293826005280	D-loop; other site
293826005281	H-loop/switch region; other site
293826005282	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
293826005283	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
293826005284	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826005285	Walker A/P-loop; other site
293826005286	ATP binding site [chemical binding]; other site
293826005287	Q-loop/lid; other site
293826005288	ABC transporter signature motif; other site
293826005289	Walker B; other site
293826005290	D-loop; other site
293826005291	H-loop/switch region; other site
293826005292	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
293826005293	Methyltransferase domain; Region: Methyltransf_31; pfam13847
293826005294	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826005295	S-adenosylmethionine binding site [chemical binding]; other site
293826005296	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
293826005297	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
293826005298	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
293826005299	catalytic residue [active]
293826005300	Putative Fe-S cluster; Region: FeS; cl17515
293826005301	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
293826005302	dimerization interface [polypeptide binding]; other site
293826005303	putative DNA binding site [nucleotide binding]; other site
293826005304	putative Zn2+ binding site [ion binding]; other site
293826005305	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
293826005306	ACS interaction site; other site
293826005307	CODH interaction site; other site
293826005308	Prismane/CO dehydrogenase family; Region: Prismane; pfam03063
293826005309	cubane metal cluster (B-cluster) [ion binding]; other site
293826005310	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
293826005311	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
293826005312	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
293826005313	P-loop; other site
293826005314	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
293826005315	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
293826005316	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
293826005317	Potassium binding sites [ion binding]; other site
293826005318	Cesium cation binding sites [ion binding]; other site
293826005319	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
293826005320	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
293826005321	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
293826005322	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
293826005323	homodimer interface [polypeptide binding]; other site
293826005324	NADP binding site [chemical binding]; other site
293826005325	substrate binding site [chemical binding]; other site
293826005326	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
293826005327	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
293826005328	FAD binding site [chemical binding]; other site
293826005329	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
293826005330	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
293826005331	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
293826005332	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
293826005333	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
293826005334	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
293826005335	acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452
293826005336	acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165
293826005337	Putative Fe-S cluster; Region: FeS; pfam04060
293826005338	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
293826005339	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
293826005340	substrate binding pocket [chemical binding]; other site
293826005341	dimer interface [polypeptide binding]; other site
293826005342	inhibitor binding site; inhibition site
293826005343	bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529
293826005344	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
293826005345	ACS interaction site; other site
293826005346	CODH interaction site; other site
293826005347	metal cluster binding site [ion binding]; other site
293826005348	CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598
293826005349	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
293826005350	lipoyl attachment site [posttranslational modification]; other site
293826005351	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
293826005352	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
293826005353	catalytic loop [active]
293826005354	iron binding site [ion binding]; other site
293826005355	Domain of unknown function (DUF3786); Region: DUF3786; pfam12654
293826005356	Domain of unknown function (DUF3842); Region: DUF3842; pfam12953
293826005357	Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133
293826005358	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
293826005359	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
293826005360	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
293826005361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826005362	dimer interface [polypeptide binding]; other site
293826005363	conserved gate region; other site
293826005364	putative PBP binding loops; other site
293826005365	ABC-ATPase subunit interface; other site
293826005366	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
293826005367	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826005368	dimer interface [polypeptide binding]; other site
293826005369	conserved gate region; other site
293826005370	putative PBP binding loops; other site
293826005371	ABC-ATPase subunit interface; other site
293826005372	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
293826005373	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826005374	Walker A/P-loop; other site
293826005375	ATP binding site [chemical binding]; other site
293826005376	Q-loop/lid; other site
293826005377	ABC transporter signature motif; other site
293826005378	Walker B; other site
293826005379	D-loop; other site
293826005380	H-loop/switch region; other site
293826005381	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
293826005382	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
293826005383	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826005384	Walker A/P-loop; other site
293826005385	ATP binding site [chemical binding]; other site
293826005386	Q-loop/lid; other site
293826005387	ABC transporter signature motif; other site
293826005388	Walker B; other site
293826005389	D-loop; other site
293826005390	H-loop/switch region; other site
293826005391	Transcriptional regulators [Transcription]; Region: MarR; COG1846
293826005392	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
293826005393	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
293826005394	NmrA-like family; Region: NmrA; pfam05368
293826005395	NAD(P) binding site [chemical binding]; other site
293826005396	active site
293826005397	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
293826005398	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
293826005399	N-acetyl-D-glucosamine binding site [chemical binding]; other site
293826005400	catalytic residue [active]
293826005401	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
293826005402	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
293826005403	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
293826005404	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826005405	dimer interface [polypeptide binding]; other site
293826005406	conserved gate region; other site
293826005407	putative PBP binding loops; other site
293826005408	ABC-ATPase subunit interface; other site
293826005409	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
293826005410	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826005411	dimer interface [polypeptide binding]; other site
293826005412	conserved gate region; other site
293826005413	putative PBP binding loops; other site
293826005414	ABC-ATPase subunit interface; other site
293826005415	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826005416	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
293826005417	Walker A/P-loop; other site
293826005418	ATP binding site [chemical binding]; other site
293826005419	Q-loop/lid; other site
293826005420	ABC transporter signature motif; other site
293826005421	Walker B; other site
293826005422	D-loop; other site
293826005423	H-loop/switch region; other site
293826005424	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
293826005425	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
293826005426	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826005427	Walker A/P-loop; other site
293826005428	ATP binding site [chemical binding]; other site
293826005429	Q-loop/lid; other site
293826005430	ABC transporter signature motif; other site
293826005431	Walker B; other site
293826005432	D-loop; other site
293826005433	H-loop/switch region; other site
293826005434	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
293826005435	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
293826005436	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
293826005437	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
293826005438	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
293826005439	catalytic residue [active]
293826005440	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
293826005441	motif 2; other site
293826005442	active site
293826005443	motif 3; other site
293826005444	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
293826005445	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
293826005446	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
293826005447	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
293826005448	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
293826005449	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
293826005450	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
293826005451	N-acetyl-D-glucosamine binding site [chemical binding]; other site
293826005452	catalytic residue [active]
293826005453	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
293826005454	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
293826005455	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826005456	Walker A motif; other site
293826005457	ATP binding site [chemical binding]; other site
293826005458	Walker B motif; other site
293826005459	arginine finger; other site
293826005460	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
293826005461	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
293826005462	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
293826005463	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
293826005464	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826005465	dimer interface [polypeptide binding]; other site
293826005466	conserved gate region; other site
293826005467	putative PBP binding loops; other site
293826005468	ABC-ATPase subunit interface; other site
293826005469	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
293826005470	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826005471	dimer interface [polypeptide binding]; other site
293826005472	conserved gate region; other site
293826005473	putative PBP binding loops; other site
293826005474	ABC-ATPase subunit interface; other site
293826005475	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
293826005476	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826005477	Walker A/P-loop; other site
293826005478	ATP binding site [chemical binding]; other site
293826005479	Q-loop/lid; other site
293826005480	ABC transporter signature motif; other site
293826005481	Walker B; other site
293826005482	D-loop; other site
293826005483	H-loop/switch region; other site
293826005484	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
293826005485	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
293826005486	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826005487	Walker A/P-loop; other site
293826005488	ATP binding site [chemical binding]; other site
293826005489	Q-loop/lid; other site
293826005490	ABC transporter signature motif; other site
293826005491	Walker B; other site
293826005492	D-loop; other site
293826005493	H-loop/switch region; other site
293826005494	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
293826005495	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
293826005496	Bacterial SH3 domain; Region: SH3_4; pfam06347
293826005497	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
293826005498	NlpC/P60 family; Region: NLPC_P60; pfam00877
293826005499	D-glutamate deacylase; Validated; Region: PRK09061
293826005500	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
293826005501	active site
293826005502	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
293826005503	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769
293826005504	SxDxEG motif; other site
293826005505	putative active site [active]
293826005506	putative metal binding site [ion binding]; other site
293826005507	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826005508	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
293826005509	putative active site [active]
293826005510	heme pocket [chemical binding]; other site
293826005511	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826005512	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
293826005513	putative active site [active]
293826005514	heme pocket [chemical binding]; other site
293826005515	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826005516	putative active site [active]
293826005517	heme pocket [chemical binding]; other site
293826005518	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826005519	dimer interface [polypeptide binding]; other site
293826005520	phosphorylation site [posttranslational modification]
293826005521	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826005522	ATP binding site [chemical binding]; other site
293826005523	Mg2+ binding site [ion binding]; other site
293826005524	G-X-G motif; other site
293826005525	Response regulator receiver domain; Region: Response_reg; pfam00072
293826005526	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826005527	active site
293826005528	phosphorylation site [posttranslational modification]
293826005529	intermolecular recognition site; other site
293826005530	dimerization interface [polypeptide binding]; other site
293826005531	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
293826005532	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
293826005533	Transcriptional regulators [Transcription]; Region: MarR; COG1846
293826005534	MarR family; Region: MarR; pfam01047
293826005535	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
293826005536	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
293826005537	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
293826005538	putative ligand binding site [chemical binding]; other site
293826005539	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
293826005540	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
293826005541	TM-ABC transporter signature motif; other site
293826005542	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
293826005543	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
293826005544	TM-ABC transporter signature motif; other site
293826005545	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
293826005546	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
293826005547	Walker A/P-loop; other site
293826005548	ATP binding site [chemical binding]; other site
293826005549	Q-loop/lid; other site
293826005550	ABC transporter signature motif; other site
293826005551	Walker B; other site
293826005552	D-loop; other site
293826005553	H-loop/switch region; other site
293826005554	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
293826005555	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
293826005556	Walker A/P-loop; other site
293826005557	ATP binding site [chemical binding]; other site
293826005558	Q-loop/lid; other site
293826005559	ABC transporter signature motif; other site
293826005560	Walker B; other site
293826005561	D-loop; other site
293826005562	H-loop/switch region; other site
293826005563	Uncharacterized conserved protein [Function unknown]; Region: COG0397
293826005564	hypothetical protein; Validated; Region: PRK00029
293826005565	Predicted amidohydrolase [General function prediction only]; Region: COG0388
293826005566	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
293826005567	active site
293826005568	catalytic triad [active]
293826005569	dimer interface [polypeptide binding]; other site
293826005570	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
293826005571	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826005572	non-specific DNA binding site [nucleotide binding]; other site
293826005573	salt bridge; other site
293826005574	sequence-specific DNA binding site [nucleotide binding]; other site
293826005575	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
293826005576	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
293826005577	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535
293826005578	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
293826005579	substrate binding pocket [chemical binding]; other site
293826005580	dimer interface [polypeptide binding]; other site
293826005581	inhibitor binding site; inhibition site
293826005582	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
293826005583	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
293826005584	B12 binding site [chemical binding]; other site
293826005585	CmuA_CmuC_like: uncharacterized protein family similar to uroporphyrinogen decarboxylase (URO-D) and the methyltransferases CmuA and CmuC; Region: CmuA_CmuC_like; cd03308
293826005586	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
293826005587	MFS/sugar transport protein; Region: MFS_2; pfam13347
293826005588	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
293826005589	Nucleoside recognition; Region: Gate; pfam07670
293826005590	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535
293826005591	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
293826005592	substrate binding pocket [chemical binding]; other site
293826005593	dimer interface [polypeptide binding]; other site
293826005594	inhibitor binding site; inhibition site
293826005595	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
293826005596	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
293826005597	B12 binding site [chemical binding]; other site
293826005598	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
293826005599	MFS/sugar transport protein; Region: MFS_2; pfam13347
293826005600	CmuA_CmuC_like: uncharacterized protein family similar to uroporphyrinogen decarboxylase (URO-D) and the methyltransferases CmuA and CmuC; Region: CmuA_CmuC_like; cd03308
293826005601	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
293826005602	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
293826005603	B12 binding site [chemical binding]; other site
293826005604	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
293826005605	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826005606	DNA-binding site [nucleotide binding]; DNA binding site
293826005607	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
293826005608	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
293826005609	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
293826005610	catalytic loop [active]
293826005611	iron binding site [ion binding]; other site
293826005612	Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050
293826005613	Protein of unknown function (DUF1638); Region: DUF1638; pfam07796
293826005614	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
293826005615	Predicted transcriptional regulator [Transcription]; Region: COG3655
293826005616	salt bridge; other site
293826005617	non-specific DNA binding site [nucleotide binding]; other site
293826005618	sequence-specific DNA binding site [nucleotide binding]; other site
293826005619	Predicted transcriptional regulator [Transcription]; Region: COG3655
293826005620	salt bridge; other site
293826005621	non-specific DNA binding site [nucleotide binding]; other site
293826005622	sequence-specific DNA binding site [nucleotide binding]; other site
293826005623	transposase/IS protein; Provisional; Region: PRK09183
293826005624	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826005625	Walker A motif; other site
293826005626	ATP binding site [chemical binding]; other site
293826005627	Walker B motif; other site
293826005628	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
293826005629	Integrase core domain; Region: rve; pfam00665
293826005630	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826005631	non-specific DNA binding site [nucleotide binding]; other site
293826005632	salt bridge; other site
293826005633	sequence-specific DNA binding site [nucleotide binding]; other site
293826005634	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
293826005635	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
293826005636	hypothetical protein; Validated; Region: PRK08116
293826005637	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826005638	Walker A motif; other site
293826005639	ATP binding site [chemical binding]; other site
293826005640	Walker B motif; other site
293826005641	arginine finger; other site
293826005642	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
293826005643	FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244
293826005644	dimer interface [polypeptide binding]; other site
293826005645	Mn binding site [ion binding]; other site
293826005646	K binding site [ion binding]; other site
293826005647	CAAX protease self-immunity; Region: Abi; pfam02517
293826005648	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
293826005649	active site
293826005650	catalytic residues [active]
293826005651	PemK-like protein; Region: PemK; cl00995
293826005652	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
293826005653	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
293826005654	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826005655	Coenzyme A binding pocket [chemical binding]; other site
293826005656	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826005657	Coenzyme A binding pocket [chemical binding]; other site
293826005658	Transposase; Region: DEDD_Tnp_IS110; pfam01548
293826005659	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
293826005660	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
293826005661	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
293826005662	catalytic motif [active]
293826005663	Catalytic residue [active]
293826005664	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
293826005665	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
293826005666	Peptidase M15; Region: Peptidase_M15_3; cl01194
293826005667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
293826005668	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
293826005669	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
293826005670	HNH endonuclease; Region: HNH_2; pfam13391
293826005671	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
293826005672	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
293826005673	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826005674	DNA binding residues [nucleotide binding]
293826005675	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179
293826005676	PLD-like domain; Region: PLDc_2; pfam13091
293826005677	putative active site [active]
293826005678	catalytic site [active]
293826005679	DEAD-like helicases superfamily; Region: DEXDc; smart00487
293826005680	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
293826005681	ATP binding site [chemical binding]; other site
293826005682	putative Mg++ binding site [ion binding]; other site
293826005683	nucleotide binding region [chemical binding]; other site
293826005684	helicase superfamily c-terminal domain; Region: HELICc; smart00490
293826005685	ATP-binding site [chemical binding]; other site
293826005686	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
293826005687	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826005688	TPR motif; other site
293826005689	TPR repeat; Region: TPR_11; pfam13414
293826005690	binding surface
293826005691	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
293826005692	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826005693	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826005694	DNA binding residues [nucleotide binding]
293826005695	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
293826005696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
293826005697	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
293826005698	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
293826005699	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
293826005700	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
293826005701	Mechanosensitive ion channel; Region: MS_channel; pfam00924
293826005702	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826005703	Zn2+ binding site [ion binding]; other site
293826005704	Mg2+ binding site [ion binding]; other site
293826005705	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
293826005706	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
293826005707	glutamine binding [chemical binding]; other site
293826005708	catalytic triad [active]
293826005709	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
293826005710	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
293826005711	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
293826005712	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
293826005713	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
293826005714	homodimer interface [polypeptide binding]; other site
293826005715	substrate-cofactor binding pocket; other site
293826005716	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826005717	catalytic residue [active]
293826005718	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
293826005719	homodecamer interface [polypeptide binding]; other site
293826005720	GTP cyclohydrolase I; Provisional; Region: PLN03044
293826005721	active site
293826005722	putative catalytic site residues [active]
293826005723	zinc binding site [ion binding]; other site
293826005724	GTP-CH-I/GFRP interaction surface; other site
293826005725	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
293826005726	dihydropteroate synthase; Region: DHPS; TIGR01496
293826005727	substrate binding pocket [chemical binding]; other site
293826005728	dimer interface [polypeptide binding]; other site
293826005729	inhibitor binding site; inhibition site
293826005730	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
293826005731	homooctamer interface [polypeptide binding]; other site
293826005732	active site
293826005733	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
293826005734	catalytic center binding site [active]
293826005735	ATP binding site [chemical binding]; other site
293826005736	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
293826005737	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
293826005738	Serpin (serine protease inhibitor); Region: Serpin; pfam00079
293826005739	serpin-like protein; Provisional; Region: PHA02660
293826005740	reactive center loop; other site
293826005741	Small acid-soluble spore protein H family; Region: SspH; pfam08141
293826005742	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
293826005743	histidyl-tRNA synthetase; Provisional; Region: PRK12420
293826005744	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
293826005745	dimer interface [polypeptide binding]; other site
293826005746	motif 1; other site
293826005747	active site
293826005748	motif 2; other site
293826005749	motif 3; other site
293826005750	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
293826005751	anticodon binding site; other site
293826005752	PAS domain S-box; Region: sensory_box; TIGR00229
293826005753	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826005754	putative active site [active]
293826005755	heme pocket [chemical binding]; other site
293826005756	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
293826005757	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
293826005758	metal binding site [ion binding]; metal-binding site
293826005759	active site
293826005760	I-site; other site
293826005761	hypothetical protein; Provisional; Region: PRK03881
293826005762	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
293826005763	AMMECR1; Region: AMMECR1; pfam01871
293826005764	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
293826005765	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826005766	FeS/SAM binding site; other site
293826005767	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
293826005768	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
293826005769	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
293826005770	Walker A/P-loop; other site
293826005771	ATP binding site [chemical binding]; other site
293826005772	Q-loop/lid; other site
293826005773	ABC transporter signature motif; other site
293826005774	Walker B; other site
293826005775	D-loop; other site
293826005776	H-loop/switch region; other site
293826005777	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
293826005778	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
293826005779	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826005780	Walker A/P-loop; other site
293826005781	ATP binding site [chemical binding]; other site
293826005782	Q-loop/lid; other site
293826005783	ABC transporter signature motif; other site
293826005784	Walker B; other site
293826005785	D-loop; other site
293826005786	H-loop/switch region; other site
293826005787	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
293826005788	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
293826005789	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
293826005790	Domain of unknown function DUF20; Region: UPF0118; pfam01594
293826005791	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
293826005792	synthetase active site [active]
293826005793	NTP binding site [chemical binding]; other site
293826005794	metal binding site [ion binding]; metal-binding site
293826005795	Ion transport protein; Region: Ion_trans; pfam00520
293826005796	Ion channel; Region: Ion_trans_2; pfam07885
293826005797	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
293826005798	Transglycosylase; Region: Transgly; pfam00912
293826005799	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
293826005800	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
293826005801	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
293826005802	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
293826005803	catalytic residues [active]
293826005804	Recombinase; Region: Recombinase; pfam07508
293826005805	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
293826005806	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826005807	non-specific DNA binding site [nucleotide binding]; other site
293826005808	salt bridge; other site
293826005809	sequence-specific DNA binding site [nucleotide binding]; other site
293826005810	Predicted transcriptional regulator [Transcription]; Region: COG2378
293826005811	HTH domain; Region: HTH_11; pfam08279
293826005812	WYL domain; Region: WYL; pfam13280
293826005813	Transposase domain (DUF772); Region: DUF772; pfam05598
293826005814	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
293826005815	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09754
293826005816	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909
293826005817	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
293826005818	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
293826005819	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
293826005820	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
293826005821	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
293826005822	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
293826005823	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
293826005824	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
293826005825	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
293826005826	Protein of unknown function DUF45; Region: DUF45; pfam01863
293826005827	RNase_H superfamily; Region: RNase_H_2; pfam13482
293826005828	active site
293826005829	catalytic site [active]
293826005830	substrate binding site [chemical binding]; other site
293826005831	S-layer homology domain; Region: SLH; pfam00395
293826005832	S-layer homology domain; Region: SLH; pfam00395
293826005833	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
293826005834	Part of AAA domain; Region: AAA_19; pfam13245
293826005835	Family description; Region: UvrD_C_2; pfam13538
293826005836	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
293826005837	active site
293826005838	homotetramer interface [polypeptide binding]; other site
293826005839	homodimer interface [polypeptide binding]; other site
293826005840	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
293826005841	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
293826005842	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
293826005843	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
293826005844	catalytic residue [active]
293826005845	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
293826005846	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
293826005847	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
293826005848	Ligand Binding Site [chemical binding]; other site
293826005849	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
293826005850	trimer interface [polypeptide binding]; other site
293826005851	dimer interface [polypeptide binding]; other site
293826005852	putative active site [active]
293826005853	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
293826005854	MPT binding site; other site
293826005855	trimer interface [polypeptide binding]; other site
293826005856	Membrane protein of unknown function; Region: DUF360; pfam04020
293826005857	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
293826005858	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826005859	FeS/SAM binding site; other site
293826005860	Pyruvate formate lyase 1; Region: PFL1; cd01678
293826005861	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
293826005862	coenzyme A binding site [chemical binding]; other site
293826005863	active site
293826005864	catalytic residues [active]
293826005865	glycine loop; other site
293826005866	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
293826005867	anti sigma factor interaction site; other site
293826005868	regulatory phosphorylation site [posttranslational modification]; other site
293826005869	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
293826005870	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826005871	ATP binding site [chemical binding]; other site
293826005872	Mg2+ binding site [ion binding]; other site
293826005873	G-X-G motif; other site
293826005874	sporulation sigma factor SigF; Validated; Region: PRK05572
293826005875	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826005876	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
293826005877	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826005878	DNA binding residues [nucleotide binding]
293826005879	Stage V sporulation protein AA; Region: SporV_AA; pfam12164
293826005880	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
293826005881	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
293826005882	stage V sporulation protein AD; Validated; Region: PRK08304
293826005883	stage V sporulation protein AD; Provisional; Region: PRK12404
293826005884	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
293826005885	Stage V sporulation protein AE1; Region: SpoVAE; pfam14097
293826005886	Transglycosylase; Region: Transgly; pfam00912
293826005887	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
293826005888	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
293826005889	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783
293826005890	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
293826005891	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
293826005892	HflX GTPase family; Region: HflX; cd01878
293826005893	G1 box; other site
293826005894	GTP/Mg2+ binding site [chemical binding]; other site
293826005895	Switch I region; other site
293826005896	G2 box; other site
293826005897	G3 box; other site
293826005898	Switch II region; other site
293826005899	G4 box; other site
293826005900	G5 box; other site
293826005901	HEAT-like repeat; Region: HEAT_EZ; pfam13513
293826005902	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
293826005903	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
293826005904	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
293826005905	active site
293826005906	Ap6A binding site [chemical binding]; other site
293826005907	nudix motif; other site
293826005908	metal binding site [ion binding]; metal-binding site
293826005909	Uncharacterized conserved protein [Function unknown]; Region: COG1739
293826005910	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
293826005911	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
293826005912	CoA binding domain; Region: CoA_binding_2; pfam13380
293826005913	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
293826005914	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
293826005915	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
293826005916	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
293826005917	dimer interface [polypeptide binding]; other site
293826005918	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826005919	catalytic residue [active]
293826005920	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
293826005921	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
293826005922	homodimer interface [polypeptide binding]; other site
293826005923	NAD binding pocket [chemical binding]; other site
293826005924	ATP binding pocket [chemical binding]; other site
293826005925	Mg binding site [ion binding]; other site
293826005926	active-site loop [active]
293826005927	hypothetical protein; Validated; Region: PRK00110
293826005928	integron integrase; Region: integrase_gron; TIGR02249
293826005929	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
293826005930	active site
293826005931	DNA binding site [nucleotide binding]
293826005932	Int/Topo IB signature motif; other site
293826005933	Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706
293826005934	Predicted acetyltransferase [General function prediction only]; Region: COG3981
293826005935	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
293826005936	Coenzyme A binding pocket [chemical binding]; other site
293826005937	Phosphotransferase enzyme family; Region: APH; pfam01636
293826005938	serine/threonine protein kinase; Provisional; Region: PRK14879
293826005939	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
293826005940	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826005941	Coenzyme A binding pocket [chemical binding]; other site
293826005942	DDE superfamily endonuclease; Region: DDE_5; cl17874
293826005943	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
293826005944	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
293826005945	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826005946	Coenzyme A binding pocket [chemical binding]; other site
293826005947	Transposase domain (DUF772); Region: DUF772; pfam05598
293826005948	GrpE; Region: GrpE; pfam01025
293826005949	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826005950	non-specific DNA binding site [nucleotide binding]; other site
293826005951	salt bridge; other site
293826005952	sequence-specific DNA binding site [nucleotide binding]; other site
293826005953	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
293826005954	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826005955	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
293826005956	Coenzyme A binding pocket [chemical binding]; other site
293826005957	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
293826005958	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
293826005959	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
293826005960	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
293826005961	motif II; other site
293826005962	DDE superfamily endonuclease; Region: DDE_5; cl17874
293826005963	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869
293826005964	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
293826005965	putative metal binding site [ion binding]; other site
293826005966	DRTGG domain; Region: DRTGG; pfam07085
293826005967	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
293826005968	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
293826005969	ATP binding site [chemical binding]; other site
293826005970	Mg2+ binding site [ion binding]; other site
293826005971	G-X-G motif; other site
293826005972	DRTGG domain; Region: DRTGG; pfam07085
293826005973	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
293826005974	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
293826005975	active site
293826005976	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
293826005977	active site
293826005978	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826005979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826005980	ATP binding site [chemical binding]; other site
293826005981	G-X-G motif; other site
293826005982	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
293826005983	SLBB domain; Region: SLBB; pfam10531
293826005984	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
293826005985	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
293826005986	FMN-binding domain; Region: FMN_bind; cl01081
293826005987	electron transport complex RsxE subunit; Provisional; Region: PRK12405
293826005988	electron transport complex protein RsxA; Provisional; Region: PRK05151
293826005989	ferredoxin; Validated; Region: PRK07118
293826005990	Putative Fe-S cluster; Region: FeS; cl17515
293826005991	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
293826005992	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
293826005993	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
293826005994	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
293826005995	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
293826005996	Domain of unknown function (DUF4321); Region: DUF4321; pfam14209
293826005997	Maf-like protein; Reviewed; Region: PRK00078
293826005998	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
293826005999	active site
293826006000	dimer interface [polypeptide binding]; other site
293826006001	hypothetical protein; Reviewed; Region: PRK00024
293826006002	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
293826006003	MPN+ (JAMM) motif; other site
293826006004	Zinc-binding site [ion binding]; other site
293826006005	rod shape-determining protein MreB; Provisional; Region: PRK13927
293826006006	MreB and similar proteins; Region: MreB_like; cd10225
293826006007	nucleotide binding site [chemical binding]; other site
293826006008	Mg binding site [ion binding]; other site
293826006009	putative protofilament interaction site [polypeptide binding]; other site
293826006010	RodZ interaction site [polypeptide binding]; other site
293826006011	rod shape-determining protein MreC; Provisional; Region: PRK13922
293826006012	rod shape-determining protein MreC; Region: MreC; pfam04085
293826006013	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
293826006014	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
293826006015	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
293826006016	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
293826006017	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
293826006018	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
293826006019	septum formation inhibitor; Reviewed; Region: minC; PRK00513
293826006020	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
293826006021	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
293826006022	Switch I; other site
293826006023	Switch II; other site
293826006024	cell division topological specificity factor MinE; Provisional; Region: PRK13987
293826006025	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
293826006026	active site
293826006027	dimer interfaces [polypeptide binding]; other site
293826006028	catalytic residues [active]
293826006029	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
293826006030	Peptidase family M23; Region: Peptidase_M23; pfam01551
293826006031	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
293826006032	Peptidase family M50; Region: Peptidase_M50; pfam02163
293826006033	active site
293826006034	putative substrate binding region [chemical binding]; other site
293826006035	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
293826006036	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826006037	FeS/SAM binding site; other site
293826006038	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
293826006039	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
293826006040	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
293826006041	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
293826006042	homodimer interface [polypeptide binding]; other site
293826006043	oligonucleotide binding site [chemical binding]; other site
293826006044	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
293826006045	Protein of unknown function (DUF464); Region: DUF464; pfam04327
293826006046	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
293826006047	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
293826006048	GTPase CgtA; Reviewed; Region: obgE; PRK12297
293826006049	GTP1/OBG; Region: GTP1_OBG; pfam01018
293826006050	Obg GTPase; Region: Obg; cd01898
293826006051	G1 box; other site
293826006052	GTP/Mg2+ binding site [chemical binding]; other site
293826006053	Switch I region; other site
293826006054	G2 box; other site
293826006055	G3 box; other site
293826006056	Switch II region; other site
293826006057	G4 box; other site
293826006058	G5 box; other site
293826006059	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
293826006060	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
293826006061	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
293826006062	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
293826006063	active site
293826006064	(T/H)XGH motif; other site
293826006065	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826006066	Zn2+ binding site [ion binding]; other site
293826006067	Mg2+ binding site [ion binding]; other site
293826006068	Transcriptional regulator [Transcription]; Region: LytR; COG1316
293826006069	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
293826006070	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
293826006071	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
293826006072	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
293826006073	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
293826006074	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
293826006075	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
293826006076	HIGH motif; other site
293826006077	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
293826006078	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
293826006079	active site
293826006080	KMSKS motif; other site
293826006081	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
293826006082	tRNA binding surface [nucleotide binding]; other site
293826006083	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
293826006084	YheO-like PAS domain; Region: PAS_6; pfam08348
293826006085	HTH domain; Region: HTH_22; pfam13309
293826006086	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
293826006087	homotrimer interaction site [polypeptide binding]; other site
293826006088	putative active site [active]
293826006089	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
293826006090	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
293826006091	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
293826006092	putative L-serine binding site [chemical binding]; other site
293826006093	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
293826006094	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
293826006095	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
293826006096	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
293826006097	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
293826006098	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
293826006099	SLBB domain; Region: SLBB; pfam10531
293826006100	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
293826006101	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
293826006102	dimerization interface [polypeptide binding]; other site
293826006103	putative ATP binding site [chemical binding]; other site
293826006104	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
293826006105	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
293826006106	selenocysteine synthase; Provisional; Region: PRK04311
293826006107	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
293826006108	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
293826006109	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
293826006110	catalytic residue [active]
293826006111	Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276
293826006112	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
293826006113	G1 box; other site
293826006114	putative GEF interaction site [polypeptide binding]; other site
293826006115	GTP/Mg2+ binding site [chemical binding]; other site
293826006116	Switch I region; other site
293826006117	G2 box; other site
293826006118	G3 box; other site
293826006119	Switch II region; other site
293826006120	G4 box; other site
293826006121	G5 box; other site
293826006122	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
293826006123	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
293826006124	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
293826006125	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
293826006126	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826006127	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826006128	active site
293826006129	phosphorylation site [posttranslational modification]
293826006130	intermolecular recognition site; other site
293826006131	dimerization interface [polypeptide binding]; other site
293826006132	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826006133	DNA binding site [nucleotide binding]
293826006134	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
293826006135	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826006136	dimerization interface [polypeptide binding]; other site
293826006137	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826006138	dimer interface [polypeptide binding]; other site
293826006139	phosphorylation site [posttranslational modification]
293826006140	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826006141	ATP binding site [chemical binding]; other site
293826006142	Mg2+ binding site [ion binding]; other site
293826006143	G-X-G motif; other site
293826006144	Sporulation and spore germination; Region: Germane; pfam10646
293826006145	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
293826006146	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
293826006147	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
293826006148	tRNA pseudouridine synthase A; Reviewed; Region: PRK12434
293826006149	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
293826006150	dimerization interface 3.5A [polypeptide binding]; other site
293826006151	active site
293826006152	ferric uptake regulator; Provisional; Region: fur; PRK09462
293826006153	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
293826006154	metal binding site 2 [ion binding]; metal-binding site
293826006155	putative DNA binding helix; other site
293826006156	metal binding site 1 [ion binding]; metal-binding site
293826006157	dimer interface [polypeptide binding]; other site
293826006158	structural Zn2+ binding site [ion binding]; other site
293826006159	Domain of unknown function (DUF378); Region: DUF378; pfam04070
293826006160	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
293826006161	active site
293826006162	putative DNA-binding cleft [nucleotide binding]; other site
293826006163	dimer interface [polypeptide binding]; other site
293826006164	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
293826006165	RuvA N terminal domain; Region: RuvA_N; pfam01330
293826006166	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
293826006167	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
293826006168	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826006169	Walker A motif; other site
293826006170	ATP binding site [chemical binding]; other site
293826006171	Walker B motif; other site
293826006172	arginine finger; other site
293826006173	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
293826006174	Stage II sporulation protein; Region: SpoIID; pfam08486
293826006175	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
293826006176	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
293826006177	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
293826006178	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
293826006179	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
293826006180	Preprotein translocase subunit; Region: YajC; pfam02699
293826006181	Protein of unknown function (DUF3792); Region: DUF3792; pfam12670
293826006182	Protein of unknown function (DUF4001); Region: DUF4001; pfam13165
293826006183	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
293826006184	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826006185	FeS/SAM binding site; other site
293826006186	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
293826006187	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
293826006188	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
293826006189	trimer interface [polypeptide binding]; other site
293826006190	putative metal binding site [ion binding]; other site
293826006191	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
293826006192	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
293826006193	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
293826006194	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
293826006195	Protein export membrane protein; Region: SecD_SecF; pfam02355
293826006196	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
293826006197	ABC1 family; Region: ABC1; pfam03109
293826006198	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
293826006199	active site
293826006200	ATP binding site [chemical binding]; other site
293826006201	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
293826006202	DHH family; Region: DHH; pfam01368
293826006203	DHHA1 domain; Region: DHHA1; pfam02272
293826006204	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538
293826006205	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
293826006206	active site
293826006207	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
293826006208	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826006209	Zn2+ binding site [ion binding]; other site
293826006210	Mg2+ binding site [ion binding]; other site
293826006211	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
293826006212	synthetase active site [active]
293826006213	NTP binding site [chemical binding]; other site
293826006214	metal binding site [ion binding]; metal-binding site
293826006215	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
293826006216	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
293826006217	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
293826006218	putative active site [active]
293826006219	dimerization interface [polypeptide binding]; other site
293826006220	putative tRNAtyr binding site [nucleotide binding]; other site
293826006221	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
293826006222	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
293826006223	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
293826006224	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826006225	FeS/SAM binding site; other site
293826006226	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
293826006227	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
293826006228	dimer interface [polypeptide binding]; other site
293826006229	motif 1; other site
293826006230	active site
293826006231	motif 2; other site
293826006232	motif 3; other site
293826006233	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
293826006234	anticodon binding site; other site
293826006235	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
293826006236	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
293826006237	dimer interface [polypeptide binding]; other site
293826006238	anticodon binding site; other site
293826006239	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
293826006240	homodimer interface [polypeptide binding]; other site
293826006241	motif 1; other site
293826006242	active site
293826006243	motif 2; other site
293826006244	GAD domain; Region: GAD; pfam02938
293826006245	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
293826006246	motif 3; other site
293826006247	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
293826006248	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
293826006249	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
293826006250	putative ATP binding site [chemical binding]; other site
293826006251	putative substrate interface [chemical binding]; other site
293826006252	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
293826006253	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
293826006254	Uncharacterized conserved protein [Function unknown]; Region: COG2966
293826006255	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
293826006256	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
293826006257	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
293826006258	dimer interface [polypeptide binding]; other site
293826006259	active site
293826006260	glycine-pyridoxal phosphate binding site [chemical binding]; other site
293826006261	folate binding site [chemical binding]; other site
293826006262	PAS fold; Region: PAS_4; pfam08448
293826006263	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826006264	putative active site [active]
293826006265	heme pocket [chemical binding]; other site
293826006266	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
293826006267	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826006268	Walker A motif; other site
293826006269	ATP binding site [chemical binding]; other site
293826006270	Walker B motif; other site
293826006271	arginine finger; other site
293826006272	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
293826006273	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
293826006274	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
293826006275	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
293826006276	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
293826006277	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
293826006278	catalytic residue [active]
293826006279	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
293826006280	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
293826006281	B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067
293826006282	B12 binding site [chemical binding]; other site
293826006283	cobalt ligand [ion binding]; other site
293826006284	MutL protein; Region: MutL; pfam13941
293826006285	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
293826006286	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
293826006287	dimer interface [polypeptide binding]; other site
293826006288	active site
293826006289	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
293826006290	substrate binding site [chemical binding]; other site
293826006291	catalytic residue [active]
293826006292	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
293826006293	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
293826006294	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
293826006295	catalytic residues [active]
293826006296	catalytic nucleophile [active]
293826006297	Presynaptic Site I dimer interface [polypeptide binding]; other site
293826006298	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
293826006299	Synaptic Flat tetramer interface [polypeptide binding]; other site
293826006300	Synaptic Site I dimer interface [polypeptide binding]; other site
293826006301	DNA binding site [nucleotide binding]
293826006302	Recombinase; Region: Recombinase; pfam07508
293826006303	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
293826006304	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826006305	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
293826006306	Walker A motif; other site
293826006307	ATP binding site [chemical binding]; other site
293826006308	Walker B motif; other site
293826006309	arginine finger; other site
293826006310	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
293826006311	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
293826006312	active site
293826006313	catalytic triad [active]
293826006314	Domain of unknown function (DUF955); Region: DUF955; pfam06114
293826006315	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826006316	non-specific DNA binding site [nucleotide binding]; other site
293826006317	salt bridge; other site
293826006318	sequence-specific DNA binding site [nucleotide binding]; other site
293826006319	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826006320	sequence-specific DNA binding site [nucleotide binding]; other site
293826006321	salt bridge; other site
293826006322	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
293826006323	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826006324	non-specific DNA binding site [nucleotide binding]; other site
293826006325	salt bridge; other site
293826006326	sequence-specific DNA binding site [nucleotide binding]; other site
293826006327	YopX protein; Region: YopX; pfam09643
293826006328	Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338
293826006329	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533
293826006330	homodimer interface [polypeptide binding]; other site
293826006331	metal binding site [ion binding]; metal-binding site
293826006332	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
293826006333	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
293826006334	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
293826006335	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
293826006336	active site
293826006337	DNA binding site [nucleotide binding]
293826006338	Int/Topo IB signature motif; other site
293826006339	Uncharacterized conserved protein [Function unknown]; Region: COG5484
293826006340	Phage terminase small subunit; Region: Phage_terminase; pfam10668
293826006341	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
293826006342	AAA domain; Region: AAA_17; pfam13207
293826006343	AAA domain; Region: AAA_33; pfam13671
293826006344	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
293826006345	Phage portal protein; Region: Phage_portal; pfam04860
293826006346	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
293826006347	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
293826006348	Phage capsid family; Region: Phage_capsid; pfam05065
293826006349	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
293826006350	oligomerization interface [polypeptide binding]; other site
293826006351	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
293826006352	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
293826006353	Protein of unknown function (DUF2001); Region: DUF2001; pfam09393
293826006354	Phage XkdN-like protein; Region: XkdN; pfam08890
293826006355	HNH endonuclease; Region: HNH_2; pfam13391
293826006356	Phage-related protein [Function unknown]; Region: COG5412
293826006357	Protein of unknown function (DUF2577); Region: DUF2577; pfam10844
293826006358	Protein of unknown function (DUF2634); Region: DUF2634; pfam10934
293826006359	Baseplate J-like protein; Region: Baseplate_J; pfam04865
293826006360	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
293826006361	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260
293826006362	Holin family; Region: Phage_holin_4; pfam05105
293826006363	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
293826006364	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
293826006365	active site
293826006366	metal binding site [ion binding]; metal-binding site
293826006367	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
293826006368	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
293826006369	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
293826006370	tetramer interface [polypeptide binding]; other site
293826006371	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826006372	catalytic residue [active]
293826006373	recombination factor protein RarA; Reviewed; Region: PRK13342
293826006374	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826006375	Walker A motif; other site
293826006376	ATP binding site [chemical binding]; other site
293826006377	Walker B motif; other site
293826006378	arginine finger; other site
293826006379	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
293826006380	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
293826006381	chromosome segregation protein; Provisional; Region: PRK03918
293826006382	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
293826006383	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
293826006384	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
293826006385	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
293826006386	NADP binding site [chemical binding]; other site
293826006387	active site
293826006388	putative substrate binding site [chemical binding]; other site
293826006389	Predicted transcriptional regulator [Transcription]; Region: COG1959
293826006390	Transcriptional regulator; Region: Rrf2; cl17282
293826006391	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
293826006392	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
293826006393	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
293826006394	catalytic residue [active]
293826006395	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
293826006396	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
293826006397	trimerization site [polypeptide binding]; other site
293826006398	active site
293826006399	PRC-barrel domain; Region: PRC; pfam05239
293826006400	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
293826006401	Domain of unknown function DUF20; Region: UPF0118; pfam01594
293826006402	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
293826006403	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
293826006404	motif 1; other site
293826006405	active site
293826006406	motif 2; other site
293826006407	motif 3; other site
293826006408	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
293826006409	hypothetical protein; Provisional; Region: PRK05473
293826006410	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
293826006411	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
293826006412	active site
293826006413	catalytic tetrad [active]
293826006414	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
293826006415	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
293826006416	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
293826006417	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
293826006418	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
293826006419	ferric uptake regulator; Provisional; Region: fur; PRK09462
293826006420	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
293826006421	metal binding site 2 [ion binding]; metal-binding site
293826006422	putative DNA binding helix; other site
293826006423	metal binding site 1 [ion binding]; metal-binding site
293826006424	dimer interface [polypeptide binding]; other site
293826006425	structural Zn2+ binding site [ion binding]; other site
293826006426	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
293826006427	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
293826006428	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
293826006429	Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956
293826006430	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
293826006431	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826006432	S-adenosylmethionine binding site [chemical binding]; other site
293826006433	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
293826006434	Peptidase family U32; Region: Peptidase_U32; pfam01136
293826006435	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
293826006436	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
293826006437	Sugar specificity; other site
293826006438	Pyrimidine base specificity; other site
293826006439	ATP-binding site [chemical binding]; other site
293826006440	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
293826006441	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
293826006442	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
293826006443	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826006444	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
293826006445	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
293826006446	catalytic residues [active]
293826006447	catalytic nucleophile [active]
293826006448	Presynaptic Site I dimer interface [polypeptide binding]; other site
293826006449	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
293826006450	Synaptic Flat tetramer interface [polypeptide binding]; other site
293826006451	Synaptic Site I dimer interface [polypeptide binding]; other site
293826006452	DNA binding site [nucleotide binding]
293826006453	Recombinase; Region: Recombinase; pfam07508
293826006454	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
293826006455	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
293826006456	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826006457	DNA binding residues [nucleotide binding]
293826006458	flagellar operon protein TIGR03826; Region: YvyF
293826006459	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
293826006460	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
293826006461	active site
293826006462	motif I; other site
293826006463	motif II; other site
293826006464	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
293826006465	Late competence development protein ComFB; Region: ComFB; pfam10719
293826006466	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cl00505
293826006467	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cl00505
293826006468	dimer interface [polypeptide binding]; other site
293826006469	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
293826006470	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
293826006471	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
293826006472	active site
293826006473	elongation factor P; Validated; Region: PRK00529
293826006474	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
293826006475	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
293826006476	RNA binding site [nucleotide binding]; other site
293826006477	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
293826006478	RNA binding site [nucleotide binding]; other site
293826006479	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
293826006480	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
293826006481	Walker A motif; other site
293826006482	ATP binding site [chemical binding]; other site
293826006483	Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; pfam09548
293826006484	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
293826006485	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
293826006486	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546
293826006487	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
293826006488	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
293826006489	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
293826006490	Asp23 family; Region: Asp23; pfam03780
293826006491	transcription antitermination factor NusB; Region: nusB; TIGR01951
293826006492	Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533
293826006493	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
293826006494	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
293826006495	generic binding surface II; other site
293826006496	generic binding surface I; other site
293826006497	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
293826006498	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
293826006499	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
293826006500	substrate binding pocket [chemical binding]; other site
293826006501	chain length determination region; other site
293826006502	substrate-Mg2+ binding site; other site
293826006503	catalytic residues [active]
293826006504	aspartate-rich region 1; other site
293826006505	active site lid residues [active]
293826006506	aspartate-rich region 2; other site
293826006507	Divergent PAP2 family; Region: DUF212; pfam02681
293826006508	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
293826006509	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
293826006510	TPP-binding site; other site
293826006511	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
293826006512	PYR/PP interface [polypeptide binding]; other site
293826006513	dimer interface [polypeptide binding]; other site
293826006514	TPP binding site [chemical binding]; other site
293826006515	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
293826006516	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
293826006517	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
293826006518	RNA binding surface [nucleotide binding]; other site
293826006519	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
293826006520	arginine repressor; Provisional; Region: argR; PRK00441
293826006521	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
293826006522	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
293826006523	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
293826006524	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
293826006525	Walker A/P-loop; other site
293826006526	ATP binding site [chemical binding]; other site
293826006527	Q-loop/lid; other site
293826006528	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
293826006529	ABC transporter signature motif; other site
293826006530	Walker B; other site
293826006531	D-loop; other site
293826006532	H-loop/switch region; other site
293826006533	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
293826006534	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
293826006535	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
293826006536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826006537	active site
293826006538	phosphorylation site [posttranslational modification]
293826006539	intermolecular recognition site; other site
293826006540	dimerization interface [polypeptide binding]; other site
293826006541	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
293826006542	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
293826006543	active site
293826006544	catalytic site [active]
293826006545	substrate binding site [chemical binding]; other site
293826006546	RecX family; Region: RecX; cl00936
293826006547	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
293826006548	Thiamine pyrophosphokinase; Region: TPK; cl08415
293826006549	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
293826006550	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
293826006551	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
293826006552	Ligand binding site; other site
293826006553	Putative Catalytic site; other site
293826006554	DXD motif; other site
293826006555	Protein of unknown function (DUF3866); Region: DUF3866; pfam12982
293826006556	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
293826006557	dimer interface [polypeptide binding]; other site
293826006558	ADP-ribose binding site [chemical binding]; other site
293826006559	active site
293826006560	nudix motif; other site
293826006561	metal binding site [ion binding]; metal-binding site
293826006562	Integral membrane protein DUF95; Region: DUF95; cl00572
293826006563	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
293826006564	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
293826006565	active site
293826006566	Int/Topo IB signature motif; other site
293826006567	phosphopentomutase; Provisional; Region: PRK05362
293826006568	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
293826006569	purine nucleoside phosphorylase; Provisional; Region: PRK08202
293826006570	purine nucleoside phosphorylase; Provisional; Region: PRK08202
293826006571	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
293826006572	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
293826006573	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
293826006574	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
293826006575	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
293826006576	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
293826006577	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
293826006578	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
293826006579	DHH family; Region: DHH; pfam01368
293826006580	FOG: CBS domain [General function prediction only]; Region: COG0517
293826006581	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
293826006582	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
293826006583	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
293826006584	active site
293826006585	NTP binding site [chemical binding]; other site
293826006586	metal binding triad [ion binding]; metal-binding site
293826006587	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
293826006588	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
293826006589	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
293826006590	Peptidase family M50; Region: Peptidase_M50; pfam02163
293826006591	active site
293826006592	putative substrate binding region [chemical binding]; other site
293826006593	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
293826006594	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
293826006595	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
293826006596	pyrroline-5-carboxylate reductase; Region: PLN02688
293826006597	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
293826006598	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
293826006599	active site
293826006600	DNA binding site [nucleotide binding]
293826006601	Int/Topo IB signature motif; other site
293826006602	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
293826006603	LexA repressor; Validated; Region: PRK00215
293826006604	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
293826006605	Catalytic site [active]
293826006606	Transposase domain (DUF772); Region: DUF772; pfam05598
293826006607	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
293826006608	Aluminium resistance protein; Region: Alum_res; pfam06838
293826006609	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
293826006610	G1 box; other site
293826006611	GTP/Mg2+ binding site [chemical binding]; other site
293826006612	G2 box; other site
293826006613	G3 box; other site
293826006614	Switch II region; other site
293826006615	G4 box; other site
293826006616	G5 box; other site
293826006617	stage V sporulation protein K; Region: spore_V_K; TIGR02881
293826006618	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826006619	Walker A motif; other site
293826006620	ATP binding site [chemical binding]; other site
293826006621	Walker B motif; other site
293826006622	arginine finger; other site
293826006623	bacterial Hfq-like; Region: Hfq; cd01716
293826006624	hexamer interface [polypeptide binding]; other site
293826006625	Sm1 motif; other site
293826006626	RNA binding site [nucleotide binding]; other site
293826006627	Sm2 motif; other site
293826006628	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
293826006629	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
293826006630	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
293826006631	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826006632	ATP binding site [chemical binding]; other site
293826006633	Mg2+ binding site [ion binding]; other site
293826006634	G-X-G motif; other site
293826006635	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
293826006636	ATP binding site [chemical binding]; other site
293826006637	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
293826006638	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
293826006639	MutS domain I; Region: MutS_I; pfam01624
293826006640	MutS domain II; Region: MutS_II; pfam05188
293826006641	MutS domain III; Region: MutS_III; pfam05192
293826006642	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
293826006643	Walker A/P-loop; other site
293826006644	ATP binding site [chemical binding]; other site
293826006645	Q-loop/lid; other site
293826006646	ABC transporter signature motif; other site
293826006647	Walker B; other site
293826006648	D-loop; other site
293826006649	H-loop/switch region; other site
293826006650	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
293826006651	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
293826006652	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826006653	FeS/SAM binding site; other site
293826006654	TRAM domain; Region: TRAM; pfam01938
293826006655	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
293826006656	amidase catalytic site [active]
293826006657	Zn binding residues [ion binding]; other site
293826006658	substrate binding site [chemical binding]; other site
293826006659	Sporulation related domain; Region: SPOR; pfam05036
293826006660	Haemolysin XhlA; Region: XhlA; pfam10779
293826006661	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
293826006662	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
293826006663	putative active site [active]
293826006664	putative NTP binding site [chemical binding]; other site
293826006665	putative nucleic acid binding site [nucleotide binding]; other site
293826006666	four helix bundle protein; Region: TIGR02436
293826006667	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
293826006668	Uncharacterized conserved protein [Function unknown]; Region: COG1262
293826006669	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
293826006670	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
293826006671	Protein of unknown function (DUF2634); Region: DUF2634; pfam10934
293826006672	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826006673	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
293826006674	Phage XkdN-like protein; Region: XkdN; pfam08890
293826006675	Protein of unknown function (DUF2001); Region: DUF2001; pfam09393
293826006676	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
293826006677	Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289
293826006678	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
293826006679	DEAD-like helicases superfamily; Region: DEXDc; smart00487
293826006680	Uncharacterized conserved protein [Function unknown]; Region: COG5484
293826006681	ParB-like nuclease domain; Region: ParBc; pfam02195
293826006682	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
293826006683	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
293826006684	DNA methylase; Region: N6_N4_Mtase; pfam01555
293826006685	Protein of unknown function (DUF968); Region: DUF968; pfam06147
293826006686	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
293826006687	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
293826006688	dimer interface [polypeptide binding]; other site
293826006689	ssDNA binding site [nucleotide binding]; other site
293826006690	tetramer (dimer of dimers) interface [polypeptide binding]; other site
293826006691	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u2; cd11539
293826006692	metal binding site [ion binding]; metal-binding site
293826006693	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
293826006694	HNH endonuclease; Region: HNH_3; pfam13392
293826006695	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826006696	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
293826006697	Walker A motif; other site
293826006698	ATP binding site [chemical binding]; other site
293826006699	Walker B motif; other site
293826006700	arginine finger; other site
293826006701	Helix-turn-helix domain; Region: HTH_36; pfam13730
293826006702	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
293826006703	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
293826006704	RecT family; Region: RecT; cl04285
293826006705	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826006706	AAA domain; Region: AAA_23; pfam13476
293826006707	Walker A/P-loop; other site
293826006708	ATP binding site [chemical binding]; other site
293826006709	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826006710	non-specific DNA binding site [nucleotide binding]; other site
293826006711	salt bridge; other site
293826006712	sequence-specific DNA binding site [nucleotide binding]; other site
293826006713	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826006714	non-specific DNA binding site [nucleotide binding]; other site
293826006715	salt bridge; other site
293826006716	sequence-specific DNA binding site [nucleotide binding]; other site
293826006717	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
293826006718	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
293826006719	catalytic residues [active]
293826006720	catalytic nucleophile [active]
293826006721	Presynaptic Site I dimer interface [polypeptide binding]; other site
293826006722	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
293826006723	Synaptic Flat tetramer interface [polypeptide binding]; other site
293826006724	Synaptic Site I dimer interface [polypeptide binding]; other site
293826006725	DNA binding site [nucleotide binding]
293826006726	Recombinase; Region: Recombinase; pfam07508
293826006727	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
293826006728	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
293826006729	aspartate aminotransferase; Provisional; Region: PRK07568
293826006730	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
293826006731	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826006732	homodimer interface [polypeptide binding]; other site
293826006733	catalytic residue [active]
293826006734	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764
293826006735	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
293826006736	DNA binding residues [nucleotide binding]
293826006737	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
293826006738	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
293826006739	oligomer interface [polypeptide binding]; other site
293826006740	active site
293826006741	metal binding site [ion binding]; metal-binding site
293826006742	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
293826006743	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
293826006744	oligomer interface [polypeptide binding]; other site
293826006745	active site
293826006746	metal binding site [ion binding]; metal-binding site
293826006747	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
293826006748	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
293826006749	oligomer interface [polypeptide binding]; other site
293826006750	active site
293826006751	metal binding site [ion binding]; metal-binding site
293826006752	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
293826006753	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
293826006754	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826006755	S-adenosylmethionine binding site [chemical binding]; other site
293826006756	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
293826006757	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
293826006758	RNA binding site [nucleotide binding]; other site
293826006759	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
293826006760	RNA binding site [nucleotide binding]; other site
293826006761	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
293826006762	RNA binding site [nucleotide binding]; other site
293826006763	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
293826006764	RNA binding site [nucleotide binding]; other site
293826006765	domain interface; other site
293826006766	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK12360
293826006767	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
293826006768	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
293826006769	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
293826006770	putative acyl-acceptor binding pocket; other site
293826006771	cytidylate kinase; Provisional; Region: cmk; PRK00023
293826006772	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
293826006773	CMP-binding site; other site
293826006774	The sites determining sugar specificity; other site
293826006775	HI0933-like protein; Region: HI0933_like; pfam03486
293826006776	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
293826006777	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
293826006778	catalytic core [active]
293826006779	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
293826006780	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
293826006781	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
293826006782	putative active site [active]
293826006783	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
293826006784	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
293826006785	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
293826006786	TPP-binding site [chemical binding]; other site
293826006787	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
293826006788	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
293826006789	dimer interface [polypeptide binding]; other site
293826006790	PYR/PP interface [polypeptide binding]; other site
293826006791	TPP binding site [chemical binding]; other site
293826006792	substrate binding site [chemical binding]; other site
293826006793	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
293826006794	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
293826006795	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
293826006796	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
293826006797	oxaloacetate decarboxylase; Provisional; Region: PRK12331
293826006798	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
293826006799	active site
293826006800	catalytic residues [active]
293826006801	metal binding site [ion binding]; metal-binding site
293826006802	homodimer binding site [polypeptide binding]; other site
293826006803	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
293826006804	Coenzyme A binding pocket [chemical binding]; other site
293826006805	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
293826006806	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
293826006807	RNA binding surface [nucleotide binding]; other site
293826006808	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
293826006809	active site
293826006810	Glucose inhibited division protein A; Region: GIDA; pfam01134
293826006811	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
293826006812	hypothetical protein; Provisional; Region: PRK05802
293826006813	FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192
293826006814	FAD binding pocket [chemical binding]; other site
293826006815	FAD binding motif [chemical binding]; other site
293826006816	phosphate binding motif [ion binding]; other site
293826006817	beta-alpha-beta structure motif; other site
293826006818	NAD binding pocket [chemical binding]; other site
293826006819	Iron coordination center [ion binding]; other site
293826006820	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
293826006821	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
293826006822	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
293826006823	sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874
293826006824	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
293826006825	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
293826006826	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826006827	non-specific DNA binding site [nucleotide binding]; other site
293826006828	salt bridge; other site
293826006829	sequence-specific DNA binding site [nucleotide binding]; other site
293826006830	Cupin domain; Region: Cupin_2; pfam07883
293826006831	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
293826006832	spermidine synthase; Provisional; Region: PRK00811
293826006833	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826006834	S-adenosylmethionine binding site [chemical binding]; other site
293826006835	agmatinase; Region: agmatinase; TIGR01230
293826006836	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
293826006837	putative active site [active]
293826006838	Mn binding site [ion binding]; other site
293826006839	Transposase [DNA replication, recombination, and repair]; Region: COG5421
293826006840	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
293826006841	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
293826006842	tetramer interface [polypeptide binding]; other site
293826006843	active site
293826006844	aspartate aminotransferase; Provisional; Region: PRK05764
293826006845	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
293826006846	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826006847	homodimer interface [polypeptide binding]; other site
293826006848	catalytic residue [active]
293826006849	Predicted transcriptional regulators [Transcription]; Region: COG1695
293826006850	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
293826006851	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
293826006852	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
293826006853	active site
293826006854	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
293826006855	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
293826006856	ribonuclease Y; Region: RNase_Y; TIGR03319
293826006857	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826006858	Zn2+ binding site [ion binding]; other site
293826006859	Mg2+ binding site [ion binding]; other site
293826006860	recombinase A; Provisional; Region: recA; PRK09354
293826006861	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
293826006862	hexamer interface [polypeptide binding]; other site
293826006863	Walker A motif; other site
293826006864	ATP binding site [chemical binding]; other site
293826006865	Walker B motif; other site
293826006866	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
293826006867	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
293826006868	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
293826006869	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826006870	FeS/SAM binding site; other site
293826006871	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
293826006872	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
293826006873	active site residue [active]
293826006874	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
293826006875	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
293826006876	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
293826006877	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
293826006878	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
293826006879	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
293826006880	active site
293826006881	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
293826006882	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
293826006883	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
293826006884	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
293826006885	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
293826006886	NodB motif; other site
293826006887	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
293826006888	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
293826006889	RNase E interface [polypeptide binding]; other site
293826006890	trimer interface [polypeptide binding]; other site
293826006891	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
293826006892	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
293826006893	RNase E interface [polypeptide binding]; other site
293826006894	trimer interface [polypeptide binding]; other site
293826006895	active site
293826006896	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
293826006897	putative nucleic acid binding region [nucleotide binding]; other site
293826006898	G-X-X-G motif; other site
293826006899	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
293826006900	RNA binding site [nucleotide binding]; other site
293826006901	domain interface; other site
293826006902	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
293826006903	16S/18S rRNA binding site [nucleotide binding]; other site
293826006904	S13e-L30e interaction site [polypeptide binding]; other site
293826006905	25S rRNA binding site [nucleotide binding]; other site
293826006906	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
293826006907	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
293826006908	active site
293826006909	Riboflavin kinase; Region: Flavokinase; smart00904
293826006910	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
293826006911	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
293826006912	RNA binding site [nucleotide binding]; other site
293826006913	active site
293826006914	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
293826006915	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
293826006916	DHH family; Region: DHH; pfam01368
293826006917	DHHA1 domain; Region: DHHA1; pfam02272
293826006918	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
293826006919	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
293826006920	translation initiation factor IF-2; Region: IF-2; TIGR00487
293826006921	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
293826006922	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
293826006923	G1 box; other site
293826006924	putative GEF interaction site [polypeptide binding]; other site
293826006925	GTP/Mg2+ binding site [chemical binding]; other site
293826006926	Switch I region; other site
293826006927	G2 box; other site
293826006928	G3 box; other site
293826006929	Switch II region; other site
293826006930	G4 box; other site
293826006931	G5 box; other site
293826006932	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
293826006933	Translation-initiation factor 2; Region: IF-2; pfam11987
293826006934	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
293826006935	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
293826006936	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
293826006937	putative RNA binding cleft [nucleotide binding]; other site
293826006938	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
293826006939	NusA N-terminal domain; Region: NusA_N; pfam08529
293826006940	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
293826006941	RNA binding site [nucleotide binding]; other site
293826006942	homodimer interface [polypeptide binding]; other site
293826006943	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
293826006944	G-X-X-G motif; other site
293826006945	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
293826006946	G-X-X-G motif; other site
293826006947	ribosome maturation protein RimP; Reviewed; Region: PRK00092
293826006948	Sm and related proteins; Region: Sm_like; cl00259
293826006949	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
293826006950	putative oligomer interface [polypeptide binding]; other site
293826006951	putative RNA binding site [nucleotide binding]; other site
293826006952	DNA polymerase III PolC; Validated; Region: polC; PRK00448
293826006953	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
293826006954	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
293826006955	generic binding surface II; other site
293826006956	generic binding surface I; other site
293826006957	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
293826006958	active site
293826006959	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
293826006960	active site
293826006961	catalytic site [active]
293826006962	substrate binding site [chemical binding]; other site
293826006963	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
293826006964	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
293826006965	Ligand binding site; other site
293826006966	Putative Catalytic site; other site
293826006967	DXD motif; other site
293826006968	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
293826006969	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
293826006970	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
293826006971	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
293826006972	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
293826006973	active site
293826006974	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
293826006975	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
293826006976	putative substrate binding region [chemical binding]; other site
293826006977	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
293826006978	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
293826006979	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
293826006980	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
293826006981	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
293826006982	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
293826006983	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
293826006984	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
293826006985	catalytic residue [active]
293826006986	putative FPP diphosphate  binding site; other site
293826006987	putative FPP binding hydrophobic cleft; other site
293826006988	dimer interface [polypeptide binding]; other site
293826006989	putative IPP diphosphate binding site; other site
293826006990	ribosome recycling factor; Reviewed; Region: frr; PRK00083
293826006991	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
293826006992	hinge region; other site
293826006993	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
293826006994	putative nucleotide binding site [chemical binding]; other site
293826006995	uridine monophosphate binding site [chemical binding]; other site
293826006996	homohexameric interface [polypeptide binding]; other site
293826006997	elongation factor Ts; Reviewed; Region: tsf; PRK12332
293826006998	UBA/TS-N domain; Region: UBA; pfam00627
293826006999	Elongation factor TS; Region: EF_TS; pfam00889
293826007000	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
293826007001	rRNA interaction site [nucleotide binding]; other site
293826007002	S8 interaction site; other site
293826007003	putative laminin-1 binding site; other site
293826007004	YceG-like family; Region: YceG; pfam02618
293826007005	Domain of unknown function (DUF4290); Region: DUF4290; pfam14123
293826007006	Protein of unknown function (DUF342); Region: DUF342; pfam03961
293826007007	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
293826007008	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
293826007009	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826007010	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
293826007011	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826007012	DNA binding residues [nucleotide binding]
293826007013	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488
293826007014	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
293826007015	CheC-like family; Region: CheC; pfam04509
293826007016	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
293826007017	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
293826007018	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
293826007019	putative binding surface; other site
293826007020	active site
293826007021	P2 response regulator binding domain; Region: P2; pfam07194
293826007022	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
293826007023	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826007024	ATP binding site [chemical binding]; other site
293826007025	Mg2+ binding site [ion binding]; other site
293826007026	G-X-G motif; other site
293826007027	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
293826007028	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
293826007029	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826007030	active site
293826007031	phosphorylation site [posttranslational modification]
293826007032	intermolecular recognition site; other site
293826007033	dimerization interface [polypeptide binding]; other site
293826007034	CheB methylesterase; Region: CheB_methylest; pfam01339
293826007035	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
293826007036	Flagellar protein YcgR; Region: YcgR_2; pfam12945
293826007037	PilZ domain; Region: PilZ; pfam07238
293826007038	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
293826007039	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
293826007040	P-loop; other site
293826007041	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
293826007042	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
293826007043	GTP/Mg2+ binding site [chemical binding]; other site
293826007044	G4 box; other site
293826007045	G5 box; other site
293826007046	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
293826007047	G1 box; other site
293826007048	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
293826007049	FHIPEP family; Region: FHIPEP; pfam00771
293826007050	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
293826007051	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
293826007052	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
293826007053	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
293826007054	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
293826007055	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
293826007056	Response regulator receiver domain; Region: Response_reg; pfam00072
293826007057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826007058	active site
293826007059	phosphorylation site [posttranslational modification]
293826007060	intermolecular recognition site; other site
293826007061	dimerization interface [polypeptide binding]; other site
293826007062	flagellar motor switch protein; Validated; Region: PRK08119
293826007063	Chemotaxis phosphatase CheX; Region: CheX; cl15816
293826007064	CheC-like family; Region: CheC; pfam04509
293826007065	flagellar motor switch protein FliN; Region: fliN; TIGR02480
293826007066	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
293826007067	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
293826007068	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718
293826007069	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
293826007070	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
293826007071	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
293826007072	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
293826007073	ligand binding site [chemical binding]; other site
293826007074	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
293826007075	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
293826007076	Flagellar protein (FlbD); Region: FlbD; pfam06289
293826007077	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
293826007078	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
293826007079	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
293826007080	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
293826007081	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
293826007082	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
293826007083	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
293826007084	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
293826007085	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
293826007086	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
293826007087	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
293826007088	Walker A motif/ATP binding site; other site
293826007089	Walker B motif; other site
293826007090	flagellar assembly protein H; Validated; Region: fliH; PRK06669
293826007091	Flagellar assembly protein FliH; Region: FliH; pfam02108
293826007092	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
293826007093	FliG C-terminal domain; Region: FliG_C; pfam01706
293826007094	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
293826007095	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
293826007096	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
293826007097	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
293826007098	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
293826007099	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
293826007100	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
293826007101	Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815
293826007102	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
293826007103	GAF domain; Region: GAF; cl17456
293826007104	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826007105	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826007106	ATP binding site [chemical binding]; other site
293826007107	Mg2+ binding site [ion binding]; other site
293826007108	G-X-G motif; other site
293826007109	Transposase domain (DUF772); Region: DUF772; pfam05598
293826007110	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
293826007111	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
293826007112	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826007113	active site
293826007114	phosphorylation site [posttranslational modification]
293826007115	intermolecular recognition site; other site
293826007116	dimerization interface [polypeptide binding]; other site
293826007117	Response regulator receiver domain; Region: Response_reg; pfam00072
293826007118	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826007119	active site
293826007120	phosphorylation site [posttranslational modification]
293826007121	intermolecular recognition site; other site
293826007122	dimerization interface [polypeptide binding]; other site
293826007123	transcriptional repressor CodY; Validated; Region: PRK04158
293826007124	CodY GAF-like domain; Region: CodY; pfam06018
293826007125	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
293826007126	DNA topoisomerase I; Validated; Region: PRK05582
293826007127	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
293826007128	active site
293826007129	interdomain interaction site; other site
293826007130	putative metal-binding site [ion binding]; other site
293826007131	nucleotide binding site [chemical binding]; other site
293826007132	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
293826007133	domain I; other site
293826007134	DNA binding groove [nucleotide binding]
293826007135	phosphate binding site [ion binding]; other site
293826007136	domain II; other site
293826007137	domain III; other site
293826007138	nucleotide binding site [chemical binding]; other site
293826007139	catalytic site [active]
293826007140	domain IV; other site
293826007141	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
293826007142	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
293826007143	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
293826007144	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
293826007145	DNA protecting protein DprA; Region: dprA; TIGR00732
293826007146	RNA polymerase Rpc34 subunit; Region: RNA_pol_Rpc34; cl02127
293826007147	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
293826007148	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
293826007149	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826007150	Walker A motif; other site
293826007151	ATP binding site [chemical binding]; other site
293826007152	Walker B motif; other site
293826007153	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
293826007154	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
293826007155	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826007156	FeS/SAM binding site; other site
293826007157	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
293826007158	hypothetical protein; Reviewed; Region: PRK12497
293826007159	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
293826007160	RNA/DNA hybrid binding site [nucleotide binding]; other site
293826007161	active site
293826007162	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
293826007163	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
293826007164	GTP/Mg2+ binding site [chemical binding]; other site
293826007165	G4 box; other site
293826007166	G5 box; other site
293826007167	G1 box; other site
293826007168	Switch I region; other site
293826007169	G2 box; other site
293826007170	G3 box; other site
293826007171	Switch II region; other site
293826007172	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
293826007173	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
293826007174	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
293826007175	RimM N-terminal domain; Region: RimM; pfam01782
293826007176	PRC-barrel domain; Region: PRC; pfam05239
293826007177	hypothetical protein; Provisional; Region: PRK00468
293826007178	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
293826007179	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
293826007180	signal recognition particle protein; Provisional; Region: PRK10867
293826007181	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
293826007182	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
293826007183	P loop; other site
293826007184	GTP binding site [chemical binding]; other site
293826007185	Signal peptide binding domain; Region: SRP_SPB; pfam02978
293826007186	putative DNA-binding protein; Validated; Region: PRK00118
293826007187	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
293826007188	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
293826007189	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
293826007190	P loop; other site
293826007191	GTP binding site [chemical binding]; other site
293826007192	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
293826007193	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
293826007194	Walker A/P-loop; other site
293826007195	ATP binding site [chemical binding]; other site
293826007196	Q-loop/lid; other site
293826007197	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
293826007198	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
293826007199	ABC transporter signature motif; other site
293826007200	Walker B; other site
293826007201	D-loop; other site
293826007202	H-loop/switch region; other site
293826007203	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
293826007204	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826007205	FeS/SAM binding site; other site
293826007206	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
293826007207	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
293826007208	dimerization interface [polypeptide binding]; other site
293826007209	active site
293826007210	metal binding site [ion binding]; metal-binding site
293826007211	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
293826007212	dsRNA binding site [nucleotide binding]; other site
293826007213	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
293826007214	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
293826007215	dimer interface [polypeptide binding]; other site
293826007216	active site
293826007217	acyl carrier protein; Provisional; Region: acpP; PRK00982
293826007218	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
293826007219	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
293826007220	NAD(P) binding site [chemical binding]; other site
293826007221	homotetramer interface [polypeptide binding]; other site
293826007222	homodimer interface [polypeptide binding]; other site
293826007223	active site
293826007224	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
293826007225	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
293826007226	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
293826007227	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
293826007228	FMN binding site [chemical binding]; other site
293826007229	substrate binding site [chemical binding]; other site
293826007230	putative catalytic residue [active]
293826007231	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
293826007232	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
293826007233	dimer interface [polypeptide binding]; other site
293826007234	active site
293826007235	CoA binding pocket [chemical binding]; other site
293826007236	putative phosphate acyltransferase; Provisional; Region: PRK05331
293826007237	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
293826007238	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
293826007239	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
293826007240	active site 2 [active]
293826007241	active site 1 [active]
293826007242	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
293826007243	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
293826007244	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
293826007245	propionate/acetate kinase; Provisional; Region: PRK12379
293826007246	hypothetical protein; Provisional; Region: PRK13670
293826007247	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
293826007248	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
293826007249	Nucleoside recognition; Region: Gate; pfam07670
293826007250	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
293826007251	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
293826007252	active site
293826007253	(T/H)XGH motif; other site
293826007254	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
293826007255	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826007256	S-adenosylmethionine binding site [chemical binding]; other site
293826007257	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
293826007258	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
293826007259	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
293826007260	generic binding surface II; other site
293826007261	ssDNA binding site; other site
293826007262	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
293826007263	ATP binding site [chemical binding]; other site
293826007264	putative Mg++ binding site [ion binding]; other site
293826007265	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
293826007266	nucleotide binding region [chemical binding]; other site
293826007267	ATP-binding site [chemical binding]; other site
293826007268	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
293826007269	DAK2 domain; Region: Dak2; pfam02734
293826007270	Asp23 family; Region: Asp23; pfam03780
293826007271	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
293826007272	Transposase [DNA replication, recombination, and repair]; Region: COG5421
293826007273	Thiamine pyrophosphokinase; Region: TPK; cd07995
293826007274	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
293826007275	active site
293826007276	dimerization interface [polypeptide binding]; other site
293826007277	thiamine binding site [chemical binding]; other site
293826007278	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
293826007279	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
293826007280	substrate binding site [chemical binding]; other site
293826007281	hexamer interface [polypeptide binding]; other site
293826007282	metal binding site [ion binding]; metal-binding site
293826007283	GTPase RsgA; Reviewed; Region: PRK00098
293826007284	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
293826007285	RNA binding site [nucleotide binding]; other site
293826007286	homodimer interface [polypeptide binding]; other site
293826007287	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
293826007288	GTPase/Zn-binding domain interface [polypeptide binding]; other site
293826007289	GTP/Mg2+ binding site [chemical binding]; other site
293826007290	G4 box; other site
293826007291	G5 box; other site
293826007292	G1 box; other site
293826007293	Switch I region; other site
293826007294	G2 box; other site
293826007295	G3 box; other site
293826007296	Switch II region; other site
293826007297	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
293826007298	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
293826007299	active site
293826007300	ATP binding site [chemical binding]; other site
293826007301	substrate binding site [chemical binding]; other site
293826007302	activation loop (A-loop); other site
293826007303	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
293826007304	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
293826007305	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
293826007306	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
293826007307	Protein phosphatase 2C; Region: PP2C; pfam00481
293826007308	active site
293826007309	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
293826007310	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826007311	FeS/SAM binding site; other site
293826007312	16S rRNA methyltransferase B; Provisional; Region: PRK14902
293826007313	NusB family; Region: NusB; pfam01029
293826007314	putative RNA binding site [nucleotide binding]; other site
293826007315	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826007316	S-adenosylmethionine binding site [chemical binding]; other site
293826007317	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
293826007318	Protein of unknown function DUF116; Region: DUF116; pfam01976
293826007319	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
293826007320	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
293826007321	putative active site [active]
293826007322	substrate binding site [chemical binding]; other site
293826007323	putative cosubstrate binding site; other site
293826007324	catalytic site [active]
293826007325	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
293826007326	substrate binding site [chemical binding]; other site
293826007327	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
293826007328	active site
293826007329	catalytic residues [active]
293826007330	metal binding site [ion binding]; metal-binding site
293826007331	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
293826007332	primosomal protein N' Region: priA; TIGR00595
293826007333	ATP binding site [chemical binding]; other site
293826007334	putative Mg++ binding site [ion binding]; other site
293826007335	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
293826007336	nucleotide binding region [chemical binding]; other site
293826007337	ATP-binding site [chemical binding]; other site
293826007338	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
293826007339	Flavoprotein; Region: Flavoprotein; pfam02441
293826007340	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
293826007341	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
293826007342	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
293826007343	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
293826007344	catalytic site [active]
293826007345	G-X2-G-X-G-K; other site
293826007346	hypothetical protein; Provisional; Region: PRK04323
293826007347	hypothetical protein; Provisional; Region: PRK11820
293826007348	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
293826007349	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
293826007350	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
293826007351	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
293826007352	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
293826007353	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
293826007354	Domain of unknown function (DUF814); Region: DUF814; pfam05670
293826007355	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
293826007356	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
293826007357	active site
293826007358	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
293826007359	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
293826007360	RNA binding surface [nucleotide binding]; other site
293826007361	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
293826007362	active site
293826007363	lipoprotein signal peptidase; Provisional; Region: PRK14787
293826007364	lipoprotein signal peptidase; Provisional; Region: PRK14791
293826007365	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
293826007366	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
293826007367	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
293826007368	DivIVA protein; Region: DivIVA; pfam05103
293826007369	DivIVA domain; Region: DivI1A_domain; TIGR03544
293826007370	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
293826007371	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
293826007372	RNA binding surface [nucleotide binding]; other site
293826007373	YGGT family; Region: YGGT; pfam02325
293826007374	Protein of unknown function (DUF552); Region: DUF552; pfam04472
293826007375	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
293826007376	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
293826007377	catalytic residue [active]
293826007378	HlyD family secretion protein; Region: HlyD_2; pfam12700
293826007379	putative membrane fusion protein; Region: TIGR02828
293826007380	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
293826007381	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
293826007382	Walker A/P-loop; other site
293826007383	ATP binding site [chemical binding]; other site
293826007384	Q-loop/lid; other site
293826007385	ABC transporter signature motif; other site
293826007386	Walker B; other site
293826007387	D-loop; other site
293826007388	H-loop/switch region; other site
293826007389	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
293826007390	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826007391	dimer interface [polypeptide binding]; other site
293826007392	conserved gate region; other site
293826007393	putative PBP binding loops; other site
293826007394	ABC-ATPase subunit interface; other site
293826007395	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
293826007396	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
293826007397	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
293826007398	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
293826007399	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
293826007400	TM-ABC transporter signature motif; other site
293826007401	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
293826007402	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826007403	Walker A/P-loop; other site
293826007404	ATP binding site [chemical binding]; other site
293826007405	Q-loop/lid; other site
293826007406	ABC transporter signature motif; other site
293826007407	Walker B; other site
293826007408	D-loop; other site
293826007409	H-loop/switch region; other site
293826007410	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
293826007411	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
293826007412	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
293826007413	putative ligand binding site [chemical binding]; other site
293826007414	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
293826007415	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
293826007416	putative ligand binding site [chemical binding]; other site
293826007417	Response regulator receiver domain; Region: Response_reg; pfam00072
293826007418	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826007419	active site
293826007420	phosphorylation site [posttranslational modification]
293826007421	intermolecular recognition site; other site
293826007422	dimerization interface [polypeptide binding]; other site
293826007423	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
293826007424	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826007425	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826007426	dimerization interface [polypeptide binding]; other site
293826007427	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
293826007428	Histidine kinase; Region: His_kinase; pfam06580
293826007429	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826007430	ATP binding site [chemical binding]; other site
293826007431	Mg2+ binding site [ion binding]; other site
293826007432	G-X-G motif; other site
293826007433	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
293826007434	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
293826007435	ligand binding site [chemical binding]; other site
293826007436	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826007437	binding surface
293826007438	TPR motif; other site
293826007439	TPR repeat; Region: TPR_11; pfam13414
293826007440	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826007441	binding surface
293826007442	TPR motif; other site
293826007443	TPR repeat; Region: TPR_11; pfam13414
293826007444	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826007445	binding surface
293826007446	TPR motif; other site
293826007447	TPR repeat; Region: TPR_11; pfam13414
293826007448	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
293826007449	binding surface
293826007450	TPR motif; other site
293826007451	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
293826007452	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
293826007453	putative active site [active]
293826007454	catalytic site [active]
293826007455	putative metal binding site [ion binding]; other site
293826007456	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
293826007457	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826007458	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
293826007459	Walker A motif; other site
293826007460	ATP binding site [chemical binding]; other site
293826007461	Walker B motif; other site
293826007462	arginine finger; other site
293826007463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826007464	Walker A motif; other site
293826007465	ATP binding site [chemical binding]; other site
293826007466	Walker B motif; other site
293826007467	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
293826007468	Repair protein; Region: Repair_PSII; pfam04536
293826007469	LemA family; Region: LemA; cl00742
293826007470	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
293826007471	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826007472	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826007473	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826007474	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826007475	Nitroreductase family; Region: Nitroreductase; pfam00881
293826007476	FMN binding site [chemical binding]; other site
293826007477	dimer interface [polypeptide binding]; other site
293826007478	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
293826007479	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
293826007480	dimer interface [polypeptide binding]; other site
293826007481	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
293826007482	putative substrate translocation pore; other site
293826007483	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
293826007484	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
293826007485	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
293826007486	large terminase protein; Provisional; Region: 17; PHA02533
293826007487	Terminase-like family; Region: Terminase_6; pfam03237
293826007488	transposase/IS protein; Provisional; Region: PRK09183
293826007489	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826007490	Walker A motif; other site
293826007491	ATP binding site [chemical binding]; other site
293826007492	Walker B motif; other site
293826007493	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
293826007494	Integrase core domain; Region: rve; pfam00665
293826007495	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
293826007496	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826007497	non-specific DNA binding site [nucleotide binding]; other site
293826007498	salt bridge; other site
293826007499	sequence-specific DNA binding site [nucleotide binding]; other site
293826007500	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
293826007501	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
293826007502	active site
293826007503	catalytic residues [active]
293826007504	DNA binding site [nucleotide binding]
293826007505	Int/Topo IB signature motif; other site
293826007506	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
293826007507	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
293826007508	G1 box; other site
293826007509	GTP/Mg2+ binding site [chemical binding]; other site
293826007510	G2 box; other site
293826007511	Switch I region; other site
293826007512	G3 box; other site
293826007513	Switch II region; other site
293826007514	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
293826007515	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
293826007516	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
293826007517	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
293826007518	GTP-binding protein Der; Reviewed; Region: PRK00093
293826007519	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
293826007520	G1 box; other site
293826007521	GTP/Mg2+ binding site [chemical binding]; other site
293826007522	Switch I region; other site
293826007523	G2 box; other site
293826007524	Switch II region; other site
293826007525	G3 box; other site
293826007526	G4 box; other site
293826007527	G5 box; other site
293826007528	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
293826007529	G1 box; other site
293826007530	GTP/Mg2+ binding site [chemical binding]; other site
293826007531	Switch I region; other site
293826007532	G2 box; other site
293826007533	G3 box; other site
293826007534	Switch II region; other site
293826007535	G4 box; other site
293826007536	G5 box; other site
293826007537	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
293826007538	Protein of unknown function (DUF512); Region: DUF512; pfam04459
293826007539	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
293826007540	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
293826007541	YIEGIA protein; Region: YIEGIA; pfam14045
293826007542	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
293826007543	stage II sporulation protein P; Region: spore_II_P; TIGR02867
293826007544	Protein of unknown function (DUF1614); Region: DUF1614; pfam07758
293826007545	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826007546	dimerization interface [polypeptide binding]; other site
293826007547	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
293826007548	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826007549	putative active site [active]
293826007550	heme pocket [chemical binding]; other site
293826007551	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826007552	dimer interface [polypeptide binding]; other site
293826007553	phosphorylation site [posttranslational modification]
293826007554	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826007555	ATP binding site [chemical binding]; other site
293826007556	Mg2+ binding site [ion binding]; other site
293826007557	G-X-G motif; other site
293826007558	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826007559	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826007560	active site
293826007561	phosphorylation site [posttranslational modification]
293826007562	intermolecular recognition site; other site
293826007563	dimerization interface [polypeptide binding]; other site
293826007564	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826007565	DNA binding site [nucleotide binding]
293826007566	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
293826007567	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
293826007568	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
293826007569	ATP cone domain; Region: ATP-cone; pfam03477
293826007570	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
293826007571	sporulation sigma factor SigG; Reviewed; Region: PRK08215
293826007572	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826007573	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
293826007574	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826007575	DNA binding residues [nucleotide binding]
293826007576	sporulation sigma factor SigE; Reviewed; Region: PRK08301
293826007577	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826007578	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826007579	DNA binding residues [nucleotide binding]
293826007580	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
293826007581	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
293826007582	cell division protein FtsZ; Validated; Region: PRK09330
293826007583	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
293826007584	nucleotide binding site [chemical binding]; other site
293826007585	SulA interaction site; other site
293826007586	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
293826007587	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
293826007588	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
293826007589	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
293826007590	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
293826007591	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
293826007592	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
293826007593	hinge; other site
293826007594	active site
293826007595	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
293826007596	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
293826007597	active site
293826007598	homodimer interface [polypeptide binding]; other site
293826007599	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
293826007600	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
293826007601	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
293826007602	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
293826007603	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
293826007604	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
293826007605	Mg++ binding site [ion binding]; other site
293826007606	putative catalytic motif [active]
293826007607	putative substrate binding site [chemical binding]; other site
293826007608	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
293826007609	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
293826007610	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
293826007611	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
293826007612	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
293826007613	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
293826007614	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
293826007615	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
293826007616	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
293826007617	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
293826007618	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
293826007619	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
293826007620	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
293826007621	MraW methylase family; Region: Methyltransf_5; pfam01795
293826007622	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
293826007623	cell division protein MraZ; Reviewed; Region: PRK00326
293826007624	MraZ protein; Region: MraZ; pfam02381
293826007625	MraZ protein; Region: MraZ; pfam02381
293826007626	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
293826007627	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
293826007628	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
293826007629	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
293826007630	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
293826007631	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
293826007632	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
293826007633	active site
293826007634	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
293826007635	GTP-binding protein YchF; Reviewed; Region: PRK09601
293826007636	YchF GTPase; Region: YchF; cd01900
293826007637	G1 box; other site
293826007638	GTP/Mg2+ binding site [chemical binding]; other site
293826007639	Switch I region; other site
293826007640	G2 box; other site
293826007641	Switch II region; other site
293826007642	G3 box; other site
293826007643	G4 box; other site
293826007644	G5 box; other site
293826007645	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
293826007646	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
293826007647	intersubunit interface [polypeptide binding]; other site
293826007648	active site
293826007649	catalytic residue [active]
293826007650	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
293826007651	Propanediol utilisation protein PduL; Region: PduL; pfam06130
293826007652	Propanediol utilisation protein PduL; Region: PduL; pfam06130
293826007653	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
293826007654	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
293826007655	GAF domain; Region: GAF; cl17456
293826007656	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
293826007657	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
293826007658	Restriction endonuclease; Region: Mrr_cat; pfam04471
293826007659	Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214
293826007660	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
293826007661	active site
293826007662	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
293826007663	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
293826007664	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826007665	Walker A/P-loop; other site
293826007666	ATP binding site [chemical binding]; other site
293826007667	Q-loop/lid; other site
293826007668	ABC transporter signature motif; other site
293826007669	Walker B; other site
293826007670	D-loop; other site
293826007671	H-loop/switch region; other site
293826007672	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
293826007673	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
293826007674	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826007675	Walker A/P-loop; other site
293826007676	ATP binding site [chemical binding]; other site
293826007677	Q-loop/lid; other site
293826007678	ABC transporter signature motif; other site
293826007679	Walker B; other site
293826007680	D-loop; other site
293826007681	H-loop/switch region; other site
293826007682	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
293826007683	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
293826007684	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
293826007685	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826007686	dimer interface [polypeptide binding]; other site
293826007687	conserved gate region; other site
293826007688	putative PBP binding loops; other site
293826007689	ABC-ATPase subunit interface; other site
293826007690	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
293826007691	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826007692	dimer interface [polypeptide binding]; other site
293826007693	conserved gate region; other site
293826007694	putative PBP binding loops; other site
293826007695	ABC-ATPase subunit interface; other site
293826007696	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
293826007697	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
293826007698	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
293826007699	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826007700	Walker A/P-loop; other site
293826007701	ATP binding site [chemical binding]; other site
293826007702	Q-loop/lid; other site
293826007703	ABC transporter signature motif; other site
293826007704	Walker B; other site
293826007705	D-loop; other site
293826007706	H-loop/switch region; other site
293826007707	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
293826007708	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
293826007709	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826007710	Walker A/P-loop; other site
293826007711	ATP binding site [chemical binding]; other site
293826007712	Q-loop/lid; other site
293826007713	ABC transporter signature motif; other site
293826007714	Walker B; other site
293826007715	D-loop; other site
293826007716	H-loop/switch region; other site
293826007717	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
293826007718	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
293826007719	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
293826007720	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826007721	dimer interface [polypeptide binding]; other site
293826007722	conserved gate region; other site
293826007723	putative PBP binding loops; other site
293826007724	ABC-ATPase subunit interface; other site
293826007725	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
293826007726	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826007727	dimer interface [polypeptide binding]; other site
293826007728	conserved gate region; other site
293826007729	putative PBP binding loops; other site
293826007730	ABC-ATPase subunit interface; other site
293826007731	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
293826007732	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
293826007733	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
293826007734	putative active site [active]
293826007735	putative CoA binding site [chemical binding]; other site
293826007736	nudix motif; other site
293826007737	metal binding site [ion binding]; metal-binding site
293826007738	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
293826007739	ResB-like family; Region: ResB; pfam05140
293826007740	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
293826007741	Cytochrome c552; Region: Cytochrom_C552; pfam02335
293826007742	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
293826007743	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
293826007744	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
293826007745	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
293826007746	Predicted transporter (DUF2162); Region: DUF2162; cl01990
293826007747	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826007748	PAS domain; Region: PAS_9; pfam13426
293826007749	putative active site [active]
293826007750	heme pocket [chemical binding]; other site
293826007751	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
293826007752	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
293826007753	metal binding site [ion binding]; metal-binding site
293826007754	active site
293826007755	I-site; other site
293826007756	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
293826007757	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
293826007758	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
293826007759	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
293826007760	metal binding site [ion binding]; metal-binding site
293826007761	active site
293826007762	I-site; other site
293826007763	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
293826007764	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
293826007765	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826007766	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826007767	DNA binding residues [nucleotide binding]
293826007768	Putative zinc-finger; Region: zf-HC2; pfam13490
293826007769	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
293826007770	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; pfam09579
293826007771	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
293826007772	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
293826007773	DNA binding residues [nucleotide binding]
293826007774	dimer interface [polypeptide binding]; other site
293826007775	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
293826007776	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
293826007777	PBP superfamily domain; Region: PBP_like_2; cl17296
293826007778	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
293826007779	active site
293826007780	8-oxo-dGMP binding site [chemical binding]; other site
293826007781	nudix motif; other site
293826007782	metal binding site [ion binding]; metal-binding site
293826007783	Cache domain; Region: Cache_1; pfam02743
293826007784	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826007785	dimerization interface [polypeptide binding]; other site
293826007786	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826007787	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
293826007788	dimer interface [polypeptide binding]; other site
293826007789	putative CheW interface [polypeptide binding]; other site
293826007790	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
293826007791	Active site serine [active]
293826007792	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
293826007793	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
293826007794	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
293826007795	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
293826007796	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
293826007797	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
293826007798	motif II; other site
293826007799	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
293826007800	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
293826007801	metal binding site [ion binding]; metal-binding site
293826007802	putative dimer interface [polypeptide binding]; other site
293826007803	Cache domain; Region: Cache_1; pfam02743
293826007804	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
293826007805	dimerization interface [polypeptide binding]; other site
293826007806	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826007807	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
293826007808	dimer interface [polypeptide binding]; other site
293826007809	putative CheW interface [polypeptide binding]; other site
293826007810	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
293826007811	homodimer interface [polypeptide binding]; other site
293826007812	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
293826007813	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
293826007814	active site
293826007815	homodimer interface [polypeptide binding]; other site
293826007816	catalytic site [active]
293826007817	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
293826007818	homodimer interface [polypeptide binding]; other site
293826007819	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
293826007820	active site pocket [active]
293826007821	glycogen synthase; Provisional; Region: glgA; PRK00654
293826007822	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
293826007823	ADP-binding pocket [chemical binding]; other site
293826007824	homodimer interface [polypeptide binding]; other site
293826007825	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
293826007826	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
293826007827	ligand binding site; other site
293826007828	oligomer interface; other site
293826007829	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
293826007830	dimer interface [polypeptide binding]; other site
293826007831	N-terminal domain interface [polypeptide binding]; other site
293826007832	sulfate 1 binding site; other site
293826007833	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
293826007834	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
293826007835	ligand binding site; other site
293826007836	oligomer interface; other site
293826007837	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
293826007838	dimer interface [polypeptide binding]; other site
293826007839	N-terminal domain interface [polypeptide binding]; other site
293826007840	glycogen branching enzyme; Provisional; Region: PRK12313
293826007841	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
293826007842	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
293826007843	active site
293826007844	catalytic site [active]
293826007845	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
293826007846	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826007847	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
293826007848	Coenzyme A binding pocket [chemical binding]; other site
293826007849	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
293826007850	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
293826007851	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
293826007852	ATP binding site [chemical binding]; other site
293826007853	Mg++ binding site [ion binding]; other site
293826007854	motif III; other site
293826007855	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
293826007856	nucleotide binding region [chemical binding]; other site
293826007857	ATP-binding site [chemical binding]; other site
293826007858	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
293826007859	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
293826007860	putative ligand binding site [chemical binding]; other site
293826007861	putative NAD binding site [chemical binding]; other site
293826007862	catalytic site [active]
293826007863	D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205
293826007864	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
293826007865	ATP-grasp domain; Region: ATP-grasp_4; cl17255
293826007866	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
293826007867	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
293826007868	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
293826007869	Initiator Replication protein; Region: Rep_3; pfam01051
293826007870	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
293826007871	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
293826007872	active site
293826007873	nucleotide binding site [chemical binding]; other site
293826007874	HIGH motif; other site
293826007875	KMSKS motif; other site
293826007876	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
293826007877	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
293826007878	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
293826007879	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826007880	dimer interface [polypeptide binding]; other site
293826007881	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
293826007882	putative CheW interface [polypeptide binding]; other site
293826007883	Predicted permeases [General function prediction only]; Region: COG0679
293826007884	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
293826007885	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
293826007886	substrate binding site [chemical binding]; other site
293826007887	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
293826007888	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
293826007889	substrate binding site [chemical binding]; other site
293826007890	ligand binding site [chemical binding]; other site
293826007891	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
293826007892	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
293826007893	Malic enzyme, N-terminal domain; Region: malic; pfam00390
293826007894	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
293826007895	putative NAD(P) binding site [chemical binding]; other site
293826007896	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
293826007897	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826007898	active site
293826007899	phosphorylation site [posttranslational modification]
293826007900	intermolecular recognition site; other site
293826007901	dimerization interface [polypeptide binding]; other site
293826007902	sensory histidine kinase DcuS; Provisional; Region: PRK11086
293826007903	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826007904	putative active site [active]
293826007905	heme pocket [chemical binding]; other site
293826007906	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826007907	ATP binding site [chemical binding]; other site
293826007908	Mg2+ binding site [ion binding]; other site
293826007909	G-X-G motif; other site
293826007910	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
293826007911	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
293826007912	catalytic triad [active]
293826007913	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
293826007914	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
293826007915	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
293826007916	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
293826007917	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
293826007918	hypothetical protein; Provisional; Region: PRK05463
293826007919	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
293826007920	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
293826007921	putative active site [active]
293826007922	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
293826007923	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826007924	active site
293826007925	phosphorylation site [posttranslational modification]
293826007926	intermolecular recognition site; other site
293826007927	dimerization interface [polypeptide binding]; other site
293826007928	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826007929	Walker A motif; other site
293826007930	ATP binding site [chemical binding]; other site
293826007931	Walker B motif; other site
293826007932	arginine finger; other site
293826007933	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
293826007934	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
293826007935	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826007936	dimerization interface [polypeptide binding]; other site
293826007937	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826007938	putative active site [active]
293826007939	heme pocket [chemical binding]; other site
293826007940	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826007941	dimer interface [polypeptide binding]; other site
293826007942	phosphorylation site [posttranslational modification]
293826007943	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826007944	ATP binding site [chemical binding]; other site
293826007945	Mg2+ binding site [ion binding]; other site
293826007946	G-X-G motif; other site
293826007947	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
293826007948	Na binding site [ion binding]; other site
293826007949	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
293826007950	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
293826007951	Uncharacterized conserved protein [Function unknown]; Region: COG3410
293826007952	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
293826007953	RNA/DNA hybrid binding site [nucleotide binding]; other site
293826007954	active site
293826007955	Uncharacterized conserved protein [Function unknown]; Region: COG0327
293826007956	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
293826007957	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
293826007958	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
293826007959	Uncharacterized conserved protein [Function unknown]; Region: COG0327
293826007960	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
293826007961	Family of unknown function (DUF633); Region: DUF633; pfam04816
293826007962	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
293826007963	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
293826007964	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
293826007965	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826007966	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
293826007967	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826007968	DNA binding residues [nucleotide binding]
293826007969	DNA primase; Validated; Region: dnaG; PRK05667
293826007970	CHC2 zinc finger; Region: zf-CHC2; pfam01807
293826007971	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
293826007972	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
293826007973	active site
293826007974	metal binding site [ion binding]; metal-binding site
293826007975	interdomain interaction site; other site
293826007976	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
293826007977	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
293826007978	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
293826007979	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826007980	Zn2+ binding site [ion binding]; other site
293826007981	Mg2+ binding site [ion binding]; other site
293826007982	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
293826007983	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
293826007984	AzlC protein; Region: AzlC; cl00570
293826007985	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
293826007986	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826007987	DNA-binding site [nucleotide binding]; DNA binding site
293826007988	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
293826007989	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826007990	homodimer interface [polypeptide binding]; other site
293826007991	catalytic residue [active]
293826007992	FMN-binding domain; Region: FMN_bind; pfam04205
293826007993	hypothetical protein; Provisional; Region: PRK12839
293826007994	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
293826007995	L-aspartate oxidase; Provisional; Region: PRK06175
293826007996	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
293826007997	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826007998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826007999	active site
293826008000	phosphorylation site [posttranslational modification]
293826008001	intermolecular recognition site; other site
293826008002	dimerization interface [polypeptide binding]; other site
293826008003	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826008004	DNA binding site [nucleotide binding]
293826008005	Archaebacterial flagellin; Region: Arch_flagellin; cl00732
293826008006	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
293826008007	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826008008	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826008009	ATP binding site [chemical binding]; other site
293826008010	Mg2+ binding site [ion binding]; other site
293826008011	G-X-G motif; other site
293826008012	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
293826008013	Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617
293826008014	substrate binding site [chemical binding]; other site
293826008015	tetramer interface [polypeptide binding]; other site
293826008016	catalytic residue [active]
293826008017	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
293826008018	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
293826008019	FMN-binding domain; Region: FMN_bind; cl01081
293826008020	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
293826008021	L-aspartate oxidase; Provisional; Region: PRK06175
293826008022	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
293826008023	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
293826008024	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
293826008025	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
293826008026	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
293826008027	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
293826008028	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
293826008029	RNA binding surface [nucleotide binding]; other site
293826008030	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
293826008031	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
293826008032	putative homotetramer interface [polypeptide binding]; other site
293826008033	putative homodimer interface [polypeptide binding]; other site
293826008034	putative metal binding site [ion binding]; other site
293826008035	putative homodimer-homodimer interface [polypeptide binding]; other site
293826008036	putative allosteric switch controlling residues; other site
293826008037	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
293826008038	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
293826008039	Protein of unknown function (DUF1048); Region: DUF1048; cl01986
293826008040	Predicted transcriptional regulators [Transcription]; Region: COG1695
293826008041	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
293826008042	pyruvate phosphate dikinase; Provisional; Region: PRK09279
293826008043	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
293826008044	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
293826008045	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
293826008046	PEP synthetase regulatory protein; Provisional; Region: PRK05339
293826008047	HTH domain; Region: HTH_11; pfam08279
293826008048	FOG: CBS domain [General function prediction only]; Region: COG0517
293826008049	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
293826008050	glycyl-tRNA synthetase; Provisional; Region: PRK04173
293826008051	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
293826008052	motif 1; other site
293826008053	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
293826008054	active site
293826008055	motif 2; other site
293826008056	motif 3; other site
293826008057	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
293826008058	anticodon binding site; other site
293826008059	Domain of unknown function (DUF4342); Region: DUF4342; pfam14242
293826008060	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
293826008061	Recombination protein O N terminal; Region: RecO_N; pfam11967
293826008062	Recombination protein O C terminal; Region: RecO_C; pfam02565
293826008063	GTPase Era; Reviewed; Region: era; PRK00089
293826008064	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
293826008065	G1 box; other site
293826008066	GTP/Mg2+ binding site [chemical binding]; other site
293826008067	Switch I region; other site
293826008068	G2 box; other site
293826008069	Switch II region; other site
293826008070	G3 box; other site
293826008071	G4 box; other site
293826008072	G5 box; other site
293826008073	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
293826008074	active site
293826008075	catalytic motif [active]
293826008076	Zn binding site [ion binding]; other site
293826008077	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
293826008078	Uncharacterized conserved protein [Function unknown]; Region: COG2928
293826008079	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
293826008080	PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383
293826008081	active site
293826008082	metal-binding heat shock protein; Provisional; Region: PRK00016
293826008083	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
293826008084	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
293826008085	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826008086	Zn2+ binding site [ion binding]; other site
293826008087	Mg2+ binding site [ion binding]; other site
293826008088	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
293826008089	PhoH-like protein; Region: PhoH; pfam02562
293826008090	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
293826008091	YabP family; Region: YabP; cl06766
293826008092	hypothetical protein; Provisional; Region: PRK13665
293826008093	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
293826008094	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
293826008095	dimer interface [polypeptide binding]; other site
293826008096	active site residues [active]
293826008097	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
293826008098	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
293826008099	putative catalytic site [active]
293826008100	putative metal binding site [ion binding]; other site
293826008101	putative phosphate binding site [ion binding]; other site
293826008102	Transposase [DNA replication, recombination, and repair]; Region: COG5421
293826008103	Yqey-like protein; Region: YqeY; pfam09424
293826008104	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
293826008105	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
293826008106	nucleotide binding site/active site [active]
293826008107	HIT family signature motif; other site
293826008108	catalytic residue [active]
293826008109	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
293826008110	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
293826008111	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826008112	FeS/SAM binding site; other site
293826008113	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
293826008114	RNA methyltransferase, RsmE family; Region: TIGR00046
293826008115	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
293826008116	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826008117	S-adenosylmethionine binding site [chemical binding]; other site
293826008118	chaperone protein DnaJ; Provisional; Region: PRK10767
293826008119	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
293826008120	HSP70 interaction site [polypeptide binding]; other site
293826008121	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
293826008122	substrate binding site [polypeptide binding]; other site
293826008123	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
293826008124	Zn binding sites [ion binding]; other site
293826008125	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
293826008126	dimer interface [polypeptide binding]; other site
293826008127	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
293826008128	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
293826008129	nucleotide binding site [chemical binding]; other site
293826008130	NEF interaction site [polypeptide binding]; other site
293826008131	SBD interface [polypeptide binding]; other site
293826008132	GrpE; Region: GrpE; pfam01025
293826008133	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
293826008134	dimer interface [polypeptide binding]; other site
293826008135	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
293826008136	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
293826008137	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
293826008138	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826008139	FeS/SAM binding site; other site
293826008140	HemN C-terminal domain; Region: HemN_C; pfam06969
293826008141	GTP-binding protein LepA; Provisional; Region: PRK05433
293826008142	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
293826008143	G1 box; other site
293826008144	putative GEF interaction site [polypeptide binding]; other site
293826008145	GTP/Mg2+ binding site [chemical binding]; other site
293826008146	Switch I region; other site
293826008147	G2 box; other site
293826008148	G3 box; other site
293826008149	Switch II region; other site
293826008150	G4 box; other site
293826008151	G5 box; other site
293826008152	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
293826008153	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
293826008154	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
293826008155	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
293826008156	stage II sporulation protein P; Region: spore_II_P; TIGR02867
293826008157	germination protease; Provisional; Region: PRK12362
293826008158	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
293826008159	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
293826008160	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
293826008161	Competence protein; Region: Competence; pfam03772
293826008162	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
293826008163	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
293826008164	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826008165	binding surface
293826008166	TPR motif; other site
293826008167	TPR repeat; Region: TPR_11; pfam13414
293826008168	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826008169	binding surface
293826008170	Tetratricopeptide repeat; Region: TPR_12; pfam13424
293826008171	TPR motif; other site
293826008172	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
293826008173	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
293826008174	Methyltransferase domain; Region: Methyltransf_26; pfam13659
293826008175	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
293826008176	ABC-2 type transporter; Region: ABC2_membrane; cl17235
293826008177	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
293826008178	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
293826008179	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
293826008180	Walker A/P-loop; other site
293826008181	ATP binding site [chemical binding]; other site
293826008182	Q-loop/lid; other site
293826008183	ABC transporter signature motif; other site
293826008184	Walker B; other site
293826008185	D-loop; other site
293826008186	H-loop/switch region; other site
293826008187	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
293826008188	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
293826008189	active site
293826008190	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
293826008191	tetramer interfaces [polypeptide binding]; other site
293826008192	binuclear metal-binding site [ion binding]; other site
293826008193	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
293826008194	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
293826008195	ATP binding site [chemical binding]; other site
293826008196	Mg++ binding site [ion binding]; other site
293826008197	motif III; other site
293826008198	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
293826008199	nucleotide binding region [chemical binding]; other site
293826008200	ATP-binding site [chemical binding]; other site
293826008201	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
293826008202	RNA binding site [nucleotide binding]; other site
293826008203	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
293826008204	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
293826008205	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
293826008206	Spore germination protein; Region: Spore_permease; cl17796
293826008207	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
293826008208	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
293826008209	active site
293826008210	dimer interface [polypeptide binding]; other site
293826008211	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
293826008212	FtsX-like permease family; Region: FtsX; pfam02687
293826008213	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
293826008214	FtsX-like permease family; Region: FtsX; pfam02687
293826008215	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
293826008216	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
293826008217	Walker A/P-loop; other site
293826008218	ATP binding site [chemical binding]; other site
293826008219	Q-loop/lid; other site
293826008220	ABC transporter signature motif; other site
293826008221	Walker B; other site
293826008222	D-loop; other site
293826008223	H-loop/switch region; other site
293826008224	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
293826008225	HlyD family secretion protein; Region: HlyD_3; pfam13437
293826008226	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
293826008227	MgtC family; Region: MgtC; pfam02308
293826008228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
293826008229	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
293826008230	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
293826008231	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
293826008232	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
293826008233	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
293826008234	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826008235	dimerization interface [polypeptide binding]; other site
293826008236	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
293826008237	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826008238	putative active site [active]
293826008239	heme pocket [chemical binding]; other site
293826008240	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826008241	dimer interface [polypeptide binding]; other site
293826008242	phosphorylation site [posttranslational modification]
293826008243	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826008244	ATP binding site [chemical binding]; other site
293826008245	Mg2+ binding site [ion binding]; other site
293826008246	G-X-G motif; other site
293826008247	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826008248	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826008249	active site
293826008250	phosphorylation site [posttranslational modification]
293826008251	intermolecular recognition site; other site
293826008252	dimerization interface [polypeptide binding]; other site
293826008253	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826008254	DNA binding site [nucleotide binding]
293826008255	Late competence development protein ComFB; Region: ComFB; pfam10719
293826008256	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
293826008257	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
293826008258	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
293826008259	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
293826008260	Ligand binding site [chemical binding]; other site
293826008261	Electron transfer flavoprotein domain; Region: ETF; pfam01012
293826008262	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
293826008263	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
293826008264	FAD binding site [chemical binding]; other site
293826008265	homotetramer interface [polypeptide binding]; other site
293826008266	substrate binding pocket [chemical binding]; other site
293826008267	catalytic base [active]
293826008268	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
293826008269	dimer interaction site [polypeptide binding]; other site
293826008270	substrate-binding tunnel; other site
293826008271	active site
293826008272	catalytic site [active]
293826008273	substrate binding site [chemical binding]; other site
293826008274	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
293826008275	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
293826008276	putative dimer interface [polypeptide binding]; other site
293826008277	[2Fe-2S] cluster binding site [ion binding]; other site
293826008278	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
293826008279	dimer interface [polypeptide binding]; other site
293826008280	[2Fe-2S] cluster binding site [ion binding]; other site
293826008281	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
293826008282	SLBB domain; Region: SLBB; pfam10531
293826008283	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
293826008284	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
293826008285	4Fe-4S binding domain; Region: Fer4; pfam00037
293826008286	putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814
293826008287	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
293826008288	catalytic loop [active]
293826008289	iron binding site [ion binding]; other site
293826008290	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929
293826008291	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
293826008292	4Fe-4S binding domain; Region: Fer4; pfam00037
293826008293	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
293826008294	molybdopterin cofactor binding site; other site
293826008295	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
293826008296	catalytic residues [active]
293826008297	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
293826008298	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
293826008299	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
293826008300	DXD motif; other site
293826008301	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
293826008302	HflC protein; Region: hflC; TIGR01932
293826008303	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
293826008304	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
293826008305	HflK protein; Region: hflK; TIGR01933
293826008306	hypothetical protein; Provisional; Region: PRK06851
293826008307	NTPase; Region: NTPase_1; cl17478
293826008308	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
293826008309	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
293826008310	CAP-like domain; other site
293826008311	active site
293826008312	primary dimer interface [polypeptide binding]; other site
293826008313	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
293826008314	DNA gyrase B; Region: DNA_gyraseB; pfam00204
293826008315	ATP binding site [chemical binding]; other site
293826008316	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
293826008317	active site
293826008318	putative metal-binding site [ion binding]; other site
293826008319	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
293826008320	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
293826008321	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
293826008322	homotrimer interaction site [polypeptide binding]; other site
293826008323	putative active site [active]
293826008324	Protein of unknown function, DUF606; Region: DUF606; pfam04657
293826008325	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
293826008326	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
293826008327	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
293826008328	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
293826008329	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
293826008330	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
293826008331	active site
293826008332	HIGH motif; other site
293826008333	nucleotide binding site [chemical binding]; other site
293826008334	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
293826008335	active site
293826008336	KMSKS motif; other site
293826008337	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
293826008338	tRNA binding surface [nucleotide binding]; other site
293826008339	anticodon binding site; other site
293826008340	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110
293826008341	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
293826008342	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
293826008343	putative active site [active]
293826008344	catalytic site [active]
293826008345	putative metal binding site [ion binding]; other site
293826008346	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
293826008347	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
293826008348	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
293826008349	catalytic residue [active]
293826008350	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
293826008351	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
293826008352	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
293826008353	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
293826008354	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
293826008355	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
293826008356	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
293826008357	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
293826008358	peptide binding site [polypeptide binding]; other site
293826008359	dimer interface [polypeptide binding]; other site
293826008360	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
293826008361	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
293826008362	N-acetyl-D-glucosamine binding site [chemical binding]; other site
293826008363	catalytic residue [active]
293826008364	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
293826008365	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
293826008366	CoA-binding site [chemical binding]; other site
293826008367	ATP-binding [chemical binding]; other site
293826008368	DNA polymerase I; Provisional; Region: PRK05755
293826008369	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
293826008370	active site
293826008371	metal binding site 1 [ion binding]; metal-binding site
293826008372	putative 5' ssDNA interaction site; other site
293826008373	metal binding site 3; metal-binding site
293826008374	metal binding site 2 [ion binding]; metal-binding site
293826008375	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
293826008376	putative DNA binding site [nucleotide binding]; other site
293826008377	putative metal binding site [ion binding]; other site
293826008378	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
293826008379	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
293826008380	active site
293826008381	DNA binding site [nucleotide binding]
293826008382	catalytic site [active]
293826008383	Putative zinc-finger; Region: zf-HC2; pfam13490
293826008384	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
293826008385	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
293826008386	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826008387	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826008388	DNA binding residues [nucleotide binding]
293826008389	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
293826008390	Transposase [DNA replication, recombination, and repair]; Region: COG5421
293826008391	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826008392	non-specific DNA binding site [nucleotide binding]; other site
293826008393	salt bridge; other site
293826008394	sequence-specific DNA binding site [nucleotide binding]; other site
293826008395	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
293826008396	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
293826008397	Transcriptional regulator [Transcription]; Region: LysR; COG0583
293826008398	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
293826008399	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
293826008400	putative dimerization interface [polypeptide binding]; other site
293826008401	EDD domain protein, DegV family; Region: DegV; TIGR00762
293826008402	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
293826008403	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
293826008404	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
293826008405	oligomer interface [polypeptide binding]; other site
293826008406	putative active site [active]
293826008407	metal binding site [ion binding]; metal-binding site
293826008408	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
293826008409	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826008410	active site
293826008411	phosphorylation site [posttranslational modification]
293826008412	intermolecular recognition site; other site
293826008413	dimerization interface [polypeptide binding]; other site
293826008414	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
293826008415	DNA binding residues [nucleotide binding]
293826008416	dimerization interface [polypeptide binding]; other site
293826008417	Sensor protein DegS; Region: DegS; pfam05384
293826008418	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
293826008419	Histidine kinase; Region: HisKA_3; pfam07730
293826008420	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826008421	ATP binding site [chemical binding]; other site
293826008422	Mg2+ binding site [ion binding]; other site
293826008423	G-X-G motif; other site
293826008424	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
293826008425	putative CheA interaction surface; other site
293826008426	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
293826008427	imidazolonepropionase; Validated; Region: PRK09356
293826008428	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
293826008429	active site
293826008430	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
293826008431	active sites [active]
293826008432	tetramer interface [polypeptide binding]; other site
293826008433	Uncharacterized protein family (UPF0180); Region: UPF0180; pfam03698
293826008434	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
293826008435	MarR family; Region: MarR; pfam01047
293826008436	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
293826008437	Peptidase family M23; Region: Peptidase_M23; pfam01551
293826008438	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
293826008439	putative lipid kinase; Reviewed; Region: PRK13337
293826008440	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
293826008441	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
293826008442	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826008443	DNA-binding site [nucleotide binding]; DNA binding site
293826008444	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
293826008445	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826008446	homodimer interface [polypeptide binding]; other site
293826008447	catalytic residue [active]
293826008448	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
293826008449	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
293826008450	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
293826008451	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
293826008452	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
293826008453	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
293826008454	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
293826008455	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826008456	Walker A/P-loop; other site
293826008457	ATP binding site [chemical binding]; other site
293826008458	Q-loop/lid; other site
293826008459	ABC transporter signature motif; other site
293826008460	Walker B; other site
293826008461	D-loop; other site
293826008462	H-loop/switch region; other site
293826008463	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
293826008464	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
293826008465	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
293826008466	Walker A/P-loop; other site
293826008467	ATP binding site [chemical binding]; other site
293826008468	Q-loop/lid; other site
293826008469	ABC transporter signature motif; other site
293826008470	Walker B; other site
293826008471	D-loop; other site
293826008472	H-loop/switch region; other site
293826008473	arginine deiminase; Provisional; Region: PRK01388
293826008474	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
293826008475	histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856
293826008476	active site
293826008477	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
293826008478	metal binding site [ion binding]; metal-binding site
293826008479	active site
293826008480	I-site; other site
293826008481	stage V sporulation protein B; Region: spore_V_B; TIGR02900
293826008482	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
293826008483	hypothetical protein; Provisional; Region: PRK08609
293826008484	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
293826008485	active site
293826008486	primer binding site [nucleotide binding]; other site
293826008487	NTP  binding site [chemical binding]; other site
293826008488	metal binding triad [ion binding]; metal-binding site
293826008489	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
293826008490	active site
293826008491	MOSC domain; Region: MOSC; pfam03473
293826008492	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
293826008493	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
293826008494	dimer interface [polypeptide binding]; other site
293826008495	putative functional site; other site
293826008496	putative MPT binding site; other site
293826008497	PBP superfamily domain; Region: PBP_like; pfam12727
293826008498	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
293826008499	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
293826008500	dimer interface [polypeptide binding]; other site
293826008501	putative functional site; other site
293826008502	putative MPT binding site; other site
293826008503	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
293826008504	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
293826008505	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826008506	Walker A motif; other site
293826008507	ATP binding site [chemical binding]; other site
293826008508	Walker B motif; other site
293826008509	arginine finger; other site
293826008510	Peptidase family M41; Region: Peptidase_M41; pfam01434
293826008511	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
293826008512	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
293826008513	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
293826008514	active site
293826008515	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
293826008516	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
293826008517	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
293826008518	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826008519	active site
293826008520	phosphorylation site [posttranslational modification]
293826008521	intermolecular recognition site; other site
293826008522	YcbB domain; Region: YcbB; pfam08664
293826008523	Transposase domain (DUF772); Region: DUF772; pfam05598
293826008524	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
293826008525	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
293826008526	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
293826008527	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
293826008528	Putative Fe-S cluster; Region: FeS; cl17515
293826008529	Nitrogen regulatory protein P-II; Region: P-II; smart00938
293826008530	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
293826008531	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
293826008532	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
293826008533	FMN-binding domain; Region: FMN_bind; cl01081
293826008534	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
293826008535	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
293826008536	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
293826008537	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
293826008538	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
293826008539	catalytic loop [active]
293826008540	iron binding site [ion binding]; other site
293826008541	Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211
293826008542	FAD binding pocket [chemical binding]; other site
293826008543	FAD binding motif [chemical binding]; other site
293826008544	phosphate binding motif [ion binding]; other site
293826008545	beta-alpha-beta structure motif; other site
293826008546	NAD binding pocket [chemical binding]; other site
293826008547	Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729
293826008548	acetylornithine aminotransferase; Provisional; Region: PRK02627
293826008549	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
293826008550	inhibitor-cofactor binding pocket; inhibition site
293826008551	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826008552	catalytic residue [active]
293826008553	aspartate kinase; Reviewed; Region: PRK06635
293826008554	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
293826008555	putative nucleotide binding site [chemical binding]; other site
293826008556	putative catalytic residues [active]
293826008557	putative Mg ion binding site [ion binding]; other site
293826008558	putative aspartate binding site [chemical binding]; other site
293826008559	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
293826008560	putative allosteric regulatory site; other site
293826008561	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
293826008562	putative allosteric regulatory residue; other site
293826008563	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
293826008564	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
293826008565	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
293826008566	active site
293826008567	trimer interface [polypeptide binding]; other site
293826008568	substrate binding site [chemical binding]; other site
293826008569	CoA binding site [chemical binding]; other site
293826008570	dihydrodipicolinate reductase; Provisional; Region: PRK00048
293826008571	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
293826008572	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
293826008573	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
293826008574	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
293826008575	dimer interface [polypeptide binding]; other site
293826008576	active site
293826008577	catalytic residue [active]
293826008578	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
293826008579	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
293826008580	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
293826008581	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826008582	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
293826008583	Predicted amidohydrolase [General function prediction only]; Region: COG0388
293826008584	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
293826008585	putative active site [active]
293826008586	catalytic triad [active]
293826008587	dimer interface [polypeptide binding]; other site
293826008588	Spore germination protein; Region: Spore_permease; cl17796
293826008589	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
293826008590	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
293826008591	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
293826008592	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
293826008593	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
293826008594	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
293826008595	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
293826008596	active site
293826008597	substrate binding site [chemical binding]; other site
293826008598	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
293826008599	FMN binding site [chemical binding]; other site
293826008600	putative catalytic residues [active]
293826008601	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
293826008602	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826008603	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826008604	dimerization interface [polypeptide binding]; other site
293826008605	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826008606	dimer interface [polypeptide binding]; other site
293826008607	phosphorylation site [posttranslational modification]
293826008608	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826008609	ATP binding site [chemical binding]; other site
293826008610	Mg2+ binding site [ion binding]; other site
293826008611	G-X-G motif; other site
293826008612	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826008613	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826008614	active site
293826008615	phosphorylation site [posttranslational modification]
293826008616	intermolecular recognition site; other site
293826008617	dimerization interface [polypeptide binding]; other site
293826008618	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826008619	DNA binding site [nucleotide binding]
293826008620	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
293826008621	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
293826008622	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
293826008623	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
293826008624	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
293826008625	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
293826008626	Citrate transporter; Region: CitMHS; pfam03600
293826008627	putative hydratase; Provisional; Region: PRK11413
293826008628	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
293826008629	substrate binding site [chemical binding]; other site
293826008630	ligand binding site [chemical binding]; other site
293826008631	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
293826008632	substrate binding site [chemical binding]; other site
293826008633	Transcriptional regulator [Transcription]; Region: LysR; COG0583
293826008634	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
293826008635	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
293826008636	dimerization interface [polypeptide binding]; other site
293826008637	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
293826008638	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
293826008639	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
293826008640	carboxyltransferase (CT) interaction site; other site
293826008641	biotinylation site [posttranslational modification]; other site
293826008642	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458
293826008643	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
293826008644	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
293826008645	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
293826008646	oxaloacetate decarboxylase; Provisional; Region: PRK12331
293826008647	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
293826008648	active site
293826008649	catalytic residues [active]
293826008650	metal binding site [ion binding]; metal-binding site
293826008651	homodimer binding site [polypeptide binding]; other site
293826008652	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
293826008653	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826008654	dimer interface [polypeptide binding]; other site
293826008655	putative CheW interface [polypeptide binding]; other site
293826008656	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498
293826008657	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
293826008658	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
293826008659	citrate lyase subunit gamma; Provisional; Region: PRK13253
293826008660	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
293826008661	Response regulator receiver domain; Region: Response_reg; pfam00072
293826008662	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826008663	active site
293826008664	phosphorylation site [posttranslational modification]
293826008665	intermolecular recognition site; other site
293826008666	dimerization interface [polypeptide binding]; other site
293826008667	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
293826008668	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826008669	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826008670	dimer interface [polypeptide binding]; other site
293826008671	phosphorylation site [posttranslational modification]
293826008672	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826008673	ATP binding site [chemical binding]; other site
293826008674	Mg2+ binding site [ion binding]; other site
293826008675	G-X-G motif; other site
293826008676	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
293826008677	Malic enzyme, N-terminal domain; Region: malic; pfam00390
293826008678	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
293826008679	putative NAD(P) binding site [chemical binding]; other site
293826008680	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
293826008681	DNA binding residues [nucleotide binding]
293826008682	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
293826008683	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
293826008684	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
293826008685	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
293826008686	Histidine kinase; Region: HisKA_3; pfam07730
293826008687	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826008688	ATP binding site [chemical binding]; other site
293826008689	Mg2+ binding site [ion binding]; other site
293826008690	G-X-G motif; other site
293826008691	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
293826008692	active site residue [active]
293826008693	Predicted permease; Region: DUF318; cl17795
293826008694	4Fe-4S binding domain; Region: Fer4_5; pfam12801
293826008695	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
293826008696	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
293826008697	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
293826008698	BioY family; Region: BioY; pfam02632
293826008699	biotin synthase; Region: bioB; TIGR00433
293826008700	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826008701	FeS/SAM binding site; other site
293826008702	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
293826008703	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
293826008704	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826008705	dimer interface [polypeptide binding]; other site
293826008706	putative CheW interface [polypeptide binding]; other site
293826008707	PAS domain; Region: PAS_9; pfam13426
293826008708	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
293826008709	Dynamin family; Region: Dynamin_N; pfam00350
293826008710	G1 box; other site
293826008711	GTP/Mg2+ binding site [chemical binding]; other site
293826008712	G2 box; other site
293826008713	Switch I region; other site
293826008714	G3 box; other site
293826008715	Switch II region; other site
293826008716	G4 box; other site
293826008717	G5 box; other site
293826008718	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
293826008719	MgtE intracellular N domain; Region: MgtE_N; smart00924
293826008720	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
293826008721	Divalent cation transporter; Region: MgtE; pfam01769
293826008722	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
293826008723	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
293826008724	PAS domain; Region: PAS_9; pfam13426
293826008725	putative active site [active]
293826008726	heme pocket [chemical binding]; other site
293826008727	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826008728	PAS fold; Region: PAS_3; pfam08447
293826008729	putative active site [active]
293826008730	heme pocket [chemical binding]; other site
293826008731	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826008732	PAS fold; Region: PAS_3; pfam08447
293826008733	putative active site [active]
293826008734	heme pocket [chemical binding]; other site
293826008735	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
293826008736	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826008737	putative active site [active]
293826008738	heme pocket [chemical binding]; other site
293826008739	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826008740	putative active site [active]
293826008741	heme pocket [chemical binding]; other site
293826008742	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
293826008743	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
293826008744	metal binding site [ion binding]; metal-binding site
293826008745	active site
293826008746	I-site; other site
293826008747	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
293826008748	PilZ domain; Region: PilZ; pfam07238
293826008749	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
293826008750	YibE/F-like protein; Region: YibE_F; pfam07907
293826008751	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
293826008752	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
293826008753	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826008754	active site
293826008755	phosphorylation site [posttranslational modification]
293826008756	intermolecular recognition site; other site
293826008757	dimerization interface [polypeptide binding]; other site
293826008758	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826008759	Walker A motif; other site
293826008760	ATP binding site [chemical binding]; other site
293826008761	Walker B motif; other site
293826008762	arginine finger; other site
293826008763	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
293826008764	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
293826008765	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
293826008766	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826008767	dimer interface [polypeptide binding]; other site
293826008768	phosphorylation site [posttranslational modification]
293826008769	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826008770	ATP binding site [chemical binding]; other site
293826008771	Mg2+ binding site [ion binding]; other site
293826008772	G-X-G motif; other site
293826008773	Double zinc ribbon; Region: DZR; pfam12773
293826008774	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826008775	dimerization interface [polypeptide binding]; other site
293826008776	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826008777	dimer interface [polypeptide binding]; other site
293826008778	phosphorylation site [posttranslational modification]
293826008779	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826008780	ATP binding site [chemical binding]; other site
293826008781	Mg2+ binding site [ion binding]; other site
293826008782	G-X-G motif; other site
293826008783	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826008784	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826008785	active site
293826008786	phosphorylation site [posttranslational modification]
293826008787	intermolecular recognition site; other site
293826008788	dimerization interface [polypeptide binding]; other site
293826008789	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826008790	DNA binding site [nucleotide binding]
293826008791	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
293826008792	S-layer homology domain; Region: SLH; pfam00395
293826008793	S-layer homology domain; Region: SLH; pfam00395
293826008794	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
293826008795	NlpC/P60 family; Region: NLPC_P60; pfam00877
293826008796	Methyltransferase domain; Region: Methyltransf_31; pfam13847
293826008797	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826008798	S-adenosylmethionine binding site [chemical binding]; other site
293826008799	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
293826008800	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
293826008801	Predicted membrane protein [Function unknown]; Region: COG3462
293826008802	Short C-terminal domain; Region: SHOCT; pfam09851
293826008803	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
293826008804	metal-binding site [ion binding]
293826008805	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
293826008806	metal-binding site [ion binding]
293826008807	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
293826008808	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
293826008809	metal-binding site [ion binding]
293826008810	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
293826008811	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
293826008812	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
293826008813	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
293826008814	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
293826008815	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
293826008816	structural tetrad; other site
293826008817	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
293826008818	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
293826008819	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826008820	S-adenosylmethionine binding site [chemical binding]; other site
293826008821	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
293826008822	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
293826008823	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826008824	FeS/SAM binding site; other site
293826008825	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
293826008826	dimanganese center [ion binding]; other site
293826008827	Calcium binding; Region: Calci_bind_CcbP; pfam11535
293826008828	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826008829	Zn2+ binding site [ion binding]; other site
293826008830	Mg2+ binding site [ion binding]; other site
293826008831	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826008832	Zn2+ binding site [ion binding]; other site
293826008833	Mg2+ binding site [ion binding]; other site
293826008834	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
293826008835	active site residue [active]
293826008836	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
293826008837	Rhodanese Homology Domain; Region: RHOD; smart00450
293826008838	active site residue [active]
293826008839	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
293826008840	active site residue [active]
293826008841	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
293826008842	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826008843	Walker A/P-loop; other site
293826008844	ATP binding site [chemical binding]; other site
293826008845	Q-loop/lid; other site
293826008846	ABC transporter signature motif; other site
293826008847	Walker B; other site
293826008848	D-loop; other site
293826008849	H-loop/switch region; other site
293826008850	TOBE domain; Region: TOBE_2; pfam08402
293826008851	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
293826008852	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826008853	putative PBP binding loops; other site
293826008854	dimer interface [polypeptide binding]; other site
293826008855	ABC-ATPase subunit interface; other site
293826008856	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
293826008857	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826008858	conserved gate region; other site
293826008859	putative PBP binding loops; other site
293826008860	ABC-ATPase subunit interface; other site
293826008861	hypothetical protein; Provisional; Region: PRK11622
293826008862	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
293826008863	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
293826008864	Uncharacterized conserved protein [Function unknown]; Region: COG0398
293826008865	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
293826008866	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
293826008867	Cysteine-rich domain; Region: CCG; pfam02754
293826008868	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
293826008869	active site residue [active]
293826008870	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
293826008871	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
293826008872	Virulence protein [General function prediction only]; Region: COG3943
293826008873	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
293826008874	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
293826008875	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826008876	S-adenosylmethionine binding site [chemical binding]; other site
293826008877	TrkA-C domain; Region: TrkA_C; pfam02080
293826008878	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826008879	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826008880	active site
293826008881	phosphorylation site [posttranslational modification]
293826008882	intermolecular recognition site; other site
293826008883	dimerization interface [polypeptide binding]; other site
293826008884	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826008885	DNA binding site [nucleotide binding]
293826008886	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
293826008887	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826008888	dimer interface [polypeptide binding]; other site
293826008889	phosphorylation site [posttranslational modification]
293826008890	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826008891	ATP binding site [chemical binding]; other site
293826008892	Mg2+ binding site [ion binding]; other site
293826008893	G-X-G motif; other site
293826008894	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
293826008895	TrkA-N domain; Region: TrkA_N; pfam02254
293826008896	TrkA-C domain; Region: TrkA_C; pfam02080
293826008897	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
293826008898	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
293826008899	TrkA-N domain; Region: TrkA_N; pfam02254
293826008900	Predicted permease [General function prediction only]; Region: COG2056
293826008901	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
293826008902	PspC domain; Region: PspC; pfam04024
293826008903	Predicted integral membrane protein [Function unknown]; Region: COG5578
293826008904	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
293826008905	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
293826008906	inhibitor binding site; inhibition site
293826008907	active site
293826008908	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
293826008909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826008910	dimer interface [polypeptide binding]; other site
293826008911	conserved gate region; other site
293826008912	putative PBP binding loops; other site
293826008913	ABC-ATPase subunit interface; other site
293826008914	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
293826008915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
293826008916	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826008917	putative PBP binding loops; other site
293826008918	dimer interface [polypeptide binding]; other site
293826008919	ABC-ATPase subunit interface; other site
293826008920	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
293826008921	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
293826008922	Response regulator receiver domain; Region: Response_reg; pfam00072
293826008923	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826008924	active site
293826008925	phosphorylation site [posttranslational modification]
293826008926	intermolecular recognition site; other site
293826008927	dimerization interface [polypeptide binding]; other site
293826008928	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826008929	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
293826008930	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826008931	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
293826008932	Histidine kinase; Region: His_kinase; pfam06580
293826008933	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826008934	ATP binding site [chemical binding]; other site
293826008935	Mg2+ binding site [ion binding]; other site
293826008936	G-X-G motif; other site
293826008937	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
293826008938	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
293826008939	Walker A/P-loop; other site
293826008940	ATP binding site [chemical binding]; other site
293826008941	Q-loop/lid; other site
293826008942	ABC transporter signature motif; other site
293826008943	Walker B; other site
293826008944	D-loop; other site
293826008945	H-loop/switch region; other site
293826008946	TOBE domain; Region: TOBE; pfam03459
293826008947	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
293826008948	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
293826008949	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
293826008950	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
293826008951	active site
293826008952	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
293826008953	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826008954	Walker A/P-loop; other site
293826008955	ATP binding site [chemical binding]; other site
293826008956	Q-loop/lid; other site
293826008957	ABC transporter signature motif; other site
293826008958	Walker B; other site
293826008959	D-loop; other site
293826008960	H-loop/switch region; other site
293826008961	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
293826008962	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
293826008963	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826008964	Walker A/P-loop; other site
293826008965	ATP binding site [chemical binding]; other site
293826008966	Q-loop/lid; other site
293826008967	ABC transporter signature motif; other site
293826008968	Walker B; other site
293826008969	D-loop; other site
293826008970	H-loop/switch region; other site
293826008971	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
293826008972	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
293826008973	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
293826008974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826008975	dimer interface [polypeptide binding]; other site
293826008976	conserved gate region; other site
293826008977	putative PBP binding loops; other site
293826008978	ABC-ATPase subunit interface; other site
293826008979	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
293826008980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826008981	dimer interface [polypeptide binding]; other site
293826008982	conserved gate region; other site
293826008983	putative PBP binding loops; other site
293826008984	ABC-ATPase subunit interface; other site
293826008985	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
293826008986	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
293826008987	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
293826008988	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
293826008989	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
293826008990	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
293826008991	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
293826008992	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
293826008993	dimer interface [polypeptide binding]; other site
293826008994	PYR/PP interface [polypeptide binding]; other site
293826008995	TPP binding site [chemical binding]; other site
293826008996	substrate binding site [chemical binding]; other site
293826008997	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
293826008998	TPP-binding site; other site
293826008999	4Fe-4S binding domain; Region: Fer4; pfam00037
293826009000	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
293826009001	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
293826009002	homodimer interface [polypeptide binding]; other site
293826009003	substrate-cofactor binding pocket; other site
293826009004	catalytic residue [active]
293826009005	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
293826009006	Ligand Binding Site [chemical binding]; other site
293826009007	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
293826009008	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826009009	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826009010	ABC transporter; Region: ABC_tran_2; pfam12848
293826009011	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826009012	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
293826009013	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
293826009014	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
293826009015	active site
293826009016	Coat F domain; Region: Coat_F; pfam07875
293826009017	YIEGIA protein; Region: YIEGIA; pfam14045
293826009018	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
293826009019	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
293826009020	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
293826009021	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
293826009022	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
293826009023	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
293826009024	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
293826009025	catalytic loop [active]
293826009026	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
293826009027	iron binding site [ion binding]; other site
293826009028	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
293826009029	DNA topoisomerase III; Provisional; Region: PRK07726
293826009030	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
293826009031	active site
293826009032	putative interdomain interaction site [polypeptide binding]; other site
293826009033	putative metal-binding site [ion binding]; other site
293826009034	putative nucleotide binding site [chemical binding]; other site
293826009035	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
293826009036	domain I; other site
293826009037	DNA binding groove [nucleotide binding]
293826009038	phosphate binding site [ion binding]; other site
293826009039	domain II; other site
293826009040	domain III; other site
293826009041	nucleotide binding site [chemical binding]; other site
293826009042	catalytic site [active]
293826009043	domain IV; other site
293826009044	CAAX protease self-immunity; Region: Abi; pfam02517
293826009045	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
293826009046	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
293826009047	ATP binding site [chemical binding]; other site
293826009048	Mg++ binding site [ion binding]; other site
293826009049	motif III; other site
293826009050	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
293826009051	nucleotide binding region [chemical binding]; other site
293826009052	ATP-binding site [chemical binding]; other site
293826009053	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
293826009054	trimer interface [polypeptide binding]; other site
293826009055	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
293826009056	YcfA-like protein; Region: YcfA; pfam07927
293826009057	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
293826009058	Cache domain; Region: Cache_1; pfam02743
293826009059	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
293826009060	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
293826009061	putative active site [active]
293826009062	putative NTP binding site [chemical binding]; other site
293826009063	putative nucleic acid binding site [nucleotide binding]; other site
293826009064	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
293826009065	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
293826009066	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
293826009067	catalytic residues [active]
293826009068	catalytic nucleophile [active]
293826009069	Recombinase; Region: Recombinase; pfam07508
293826009070	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
293826009071	Recombinase; Region: Recombinase; pfam07508
293826009072	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
293826009073	Calcium binding; Region: Calci_bind_CcbP; pfam11535
293826009074	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
293826009075	Putative transposase; Region: Y2_Tnp; pfam04986
293826009076	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
293826009077	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
293826009078	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
293826009079	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
293826009080	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
293826009081	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826009082	Coenzyme A binding pocket [chemical binding]; other site
293826009083	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
293826009084	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826009085	non-specific DNA binding site [nucleotide binding]; other site
293826009086	salt bridge; other site
293826009087	sequence-specific DNA binding site [nucleotide binding]; other site
293826009088	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
293826009089	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826009090	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826009091	ABC transporter; Region: ABC_tran_2; pfam12848
293826009092	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826009093	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
293826009094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826009095	Walker A/P-loop; other site
293826009096	ATP binding site [chemical binding]; other site
293826009097	Q-loop/lid; other site
293826009098	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826009099	ABC transporter signature motif; other site
293826009100	Walker B; other site
293826009101	D-loop; other site
293826009102	ABC transporter; Region: ABC_tran_2; pfam12848
293826009103	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
293826009104	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
293826009105	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
293826009106	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
293826009107	substrate binding pocket [chemical binding]; other site
293826009108	dihydropteroate synthase; Region: DHPS; TIGR01496
293826009109	dimer interface [polypeptide binding]; other site
293826009110	inhibitor binding site; inhibition site
293826009111	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
293826009112	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
293826009113	B12 binding site [chemical binding]; other site
293826009114	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
293826009115	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
293826009116	FAD binding site [chemical binding]; other site
293826009117	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
293826009118	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
293826009119	homodimer interface [polypeptide binding]; other site
293826009120	substrate-cofactor binding pocket; other site
293826009121	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826009122	catalytic residue [active]
293826009123	Bacterial SH3 domain homologues; Region: SH3b; smart00287
293826009124	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
293826009125	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
293826009126	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
293826009127	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
293826009128	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
293826009129	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
293826009130	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
293826009131	ATP-grasp domain; Region: ATP-grasp_4; cl17255
293826009132	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
293826009133	IMP binding site; other site
293826009134	dimer interface [polypeptide binding]; other site
293826009135	interdomain contacts; other site
293826009136	partial ornithine binding site; other site
293826009137	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
293826009138	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
293826009139	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
293826009140	catalytic site [active]
293826009141	subunit interface [polypeptide binding]; other site
293826009142	acetylornithine aminotransferase; Provisional; Region: PRK02627
293826009143	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
293826009144	inhibitor-cofactor binding pocket; inhibition site
293826009145	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826009146	catalytic residue [active]
293826009147	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
293826009148	feedback inhibition sensing region; other site
293826009149	homohexameric interface [polypeptide binding]; other site
293826009150	nucleotide binding site [chemical binding]; other site
293826009151	N-acetyl-L-glutamate binding site [chemical binding]; other site
293826009152	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
293826009153	heterotetramer interface [polypeptide binding]; other site
293826009154	active site pocket [active]
293826009155	cleavage site
293826009156	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
293826009157	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
293826009158	methionine sulfoxide reductase B; Provisional; Region: PRK00222
293826009159	SelR domain; Region: SelR; pfam01641
293826009160	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
293826009161	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826009162	active site
293826009163	phosphorylation site [posttranslational modification]
293826009164	intermolecular recognition site; other site
293826009165	dimerization interface [polypeptide binding]; other site
293826009166	ANTAR domain; Region: ANTAR; pfam03861
293826009167	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
293826009168	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
293826009169	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
293826009170	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
293826009171	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
293826009172	GatB domain; Region: GatB_Yqey; smart00845
293826009173	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
293826009174	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
293826009175	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
293826009176	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
293826009177	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
293826009178	Dimer interface [polypeptide binding]; other site
293826009179	anticodon binding site; other site
293826009180	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
293826009181	homodimer interface [polypeptide binding]; other site
293826009182	motif 1; other site
293826009183	motif 2; other site
293826009184	active site
293826009185	motif 3; other site
293826009186	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
293826009187	Nitrogen regulatory protein P-II; Region: P-II; smart00938
293826009188	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
293826009189	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
293826009190	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
293826009191	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
293826009192	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
293826009193	Probable transposase; Region: OrfB_IS605; pfam01385
293826009194	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
293826009195	Transposase IS200 like; Region: Y1_Tnp; pfam01797
293826009196	Predicted permeases [General function prediction only]; Region: COG0679
293826009197	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
293826009198	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
293826009199	active site
293826009200	dimer interface [polypeptide binding]; other site
293826009201	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
293826009202	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
293826009203	active site
293826009204	FMN binding site [chemical binding]; other site
293826009205	substrate binding site [chemical binding]; other site
293826009206	3Fe-4S cluster binding site [ion binding]; other site
293826009207	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
293826009208	domain interface; other site
293826009209	hypothetical protein; Validated; Region: PRK00194
293826009210	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
293826009211	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048
293826009212	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
293826009213	PYR/PP interface [polypeptide binding]; other site
293826009214	dimer interface [polypeptide binding]; other site
293826009215	TPP binding site [chemical binding]; other site
293826009216	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
293826009217	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
293826009218	TPP-binding site [chemical binding]; other site
293826009219	dimer interface [polypeptide binding]; other site
293826009220	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
293826009221	ketol-acid reductoisomerase; Provisional; Region: PRK05479
293826009222	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
293826009223	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
293826009224	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
293826009225	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
293826009226	putative valine binding site [chemical binding]; other site
293826009227	dimer interface [polypeptide binding]; other site
293826009228	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
293826009229	threonine dehydratase; Provisional; Region: PRK08198
293826009230	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
293826009231	tetramer interface [polypeptide binding]; other site
293826009232	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826009233	catalytic residue [active]
293826009234	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
293826009235	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
293826009236	active site
293826009237	aspartate kinase; Reviewed; Region: PRK09034
293826009238	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
293826009239	nucleotide binding site [chemical binding]; other site
293826009240	substrate binding site [chemical binding]; other site
293826009241	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
293826009242	allosteric regulatory residue; other site
293826009243	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
293826009244	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
293826009245	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
293826009246	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
293826009247	citrate lyase subunit gamma; Provisional; Region: PRK13253
293826009248	fumarate hydratase; Provisional; Region: PRK06842
293826009249	fumarate hydratase; Provisional; Region: PRK06246
293826009250	methylaspartate ammonia-lyase; Region: B_methylAsp_ase; TIGR01502
293826009251	Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314
293826009252	dimer interface [polypeptide binding]; other site
293826009253	active site
293826009254	Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245
293826009255	substrate binding site [chemical binding]; other site
293826009256	B12 cofactor binding site [chemical binding]; other site
293826009257	heterodimer (sigma-epsilon) interface [polypeptide binding]; other site
293826009258	homodimer (epsilon-epsilon) interface [polypeptide binding]; other site
293826009259	B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072
293826009260	B12 binding site [chemical binding]; other site
293826009261	heterodimer interface [polypeptide binding]; other site
293826009262	cobalt ligand [ion binding]; other site
293826009263	Predicted transcriptional regulators [Transcription]; Region: COG1725
293826009264	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826009265	DNA-binding site [nucleotide binding]; DNA binding site
293826009266	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
293826009267	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
293826009268	PYR/PP interface [polypeptide binding]; other site
293826009269	dimer interface [polypeptide binding]; other site
293826009270	TPP binding site [chemical binding]; other site
293826009271	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
293826009272	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
293826009273	TPP-binding site [chemical binding]; other site
293826009274	dimer interface [polypeptide binding]; other site
293826009275	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
293826009276	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
293826009277	putative valine binding site [chemical binding]; other site
293826009278	dimer interface [polypeptide binding]; other site
293826009279	hypothetical protein; Provisional; Region: PRK13663
293826009280	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
293826009281	chromosome segregation protein; Provisional; Region: PRK03918
293826009282	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
293826009283	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
293826009284	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
293826009285	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
293826009286	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
293826009287	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
293826009288	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
293826009289	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
293826009290	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
293826009291	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
293826009292	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
293826009293	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
293826009294	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
293826009295	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
293826009296	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
293826009297	putative metal binding site; other site
293826009298	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826009299	binding surface
293826009300	TPR motif; other site
293826009301	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
293826009302	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
293826009303	inhibitor-cofactor binding pocket; inhibition site
293826009304	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826009305	catalytic residue [active]
293826009306	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
293826009307	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
293826009308	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
293826009309	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
293826009310	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
293826009311	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
293826009312	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
293826009313	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
293826009314	NAD(P) binding site [chemical binding]; other site
293826009315	active site
293826009316	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
293826009317	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
293826009318	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
293826009319	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
293826009320	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
293826009321	putative trimer interface [polypeptide binding]; other site
293826009322	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
293826009323	putative CoA binding site [chemical binding]; other site
293826009324	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
293826009325	putative trimer interface [polypeptide binding]; other site
293826009326	putative active site [active]
293826009327	putative substrate binding site [chemical binding]; other site
293826009328	putative CoA binding site [chemical binding]; other site
293826009329	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
293826009330	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
293826009331	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
293826009332	active site
293826009333	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
293826009334	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
293826009335	EDD domain protein, DegV family; Region: DegV; TIGR00762
293826009336	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
293826009337	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
293826009338	tartrate dehydrogenase; Region: TTC; TIGR02089
293826009339	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
293826009340	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
293826009341	substrate binding site [chemical binding]; other site
293826009342	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
293826009343	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
293826009344	substrate binding site [chemical binding]; other site
293826009345	ligand binding site [chemical binding]; other site
293826009346	2-isopropylmalate synthase; Validated; Region: PRK00915
293826009347	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
293826009348	active site
293826009349	catalytic residues [active]
293826009350	metal binding site [ion binding]; metal-binding site
293826009351	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
293826009352	Tocopherol cyclase; Region: Tocopherol_cycl; cl14571
293826009353	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
293826009354	FMN-binding domain; Region: FMN_bind; cl01081
293826009355	L-aspartate oxidase; Provisional; Region: PRK06175
293826009356	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
293826009357	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
293826009358	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
293826009359	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
293826009360	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
293826009361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
293826009362	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
293826009363	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
293826009364	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
293826009365	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
293826009366	dimerization interface [polypeptide binding]; other site
293826009367	DPS ferroxidase diiron center [ion binding]; other site
293826009368	ion pore; other site
293826009369	BCCT family transporter; Region: BCCT; pfam02028
293826009370	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
293826009371	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
293826009372	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
293826009373	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
293826009374	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
293826009375	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
293826009376	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
293826009377	putative active site [active]
293826009378	S-layer homology domain; Region: SLH; pfam00395
293826009379	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
293826009380	Competence protein A; Region: Competence_A; pfam11104
293826009381	Cell division protein FtsA; Region: FtsA; cl17206
293826009382	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
293826009383	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
293826009384	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
293826009385	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
293826009386	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
293826009387	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
293826009388	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
293826009389	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
293826009390	Walker A motif; other site
293826009391	ATP binding site [chemical binding]; other site
293826009392	Walker B motif; other site
293826009393	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
293826009394	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
293826009395	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
293826009396	Walker A motif; other site
293826009397	ATP binding site [chemical binding]; other site
293826009398	Walker B motif; other site
293826009399	PAS domain; Region: PAS_9; pfam13426
293826009400	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
293826009401	putative active site [active]
293826009402	heme pocket [chemical binding]; other site
293826009403	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
293826009404	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826009405	putative active site [active]
293826009406	heme pocket [chemical binding]; other site
293826009407	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826009408	putative active site [active]
293826009409	heme pocket [chemical binding]; other site
293826009410	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
293826009411	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
293826009412	metal binding site [ion binding]; metal-binding site
293826009413	active site
293826009414	I-site; other site
293826009415	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
293826009416	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826009417	Zn2+ binding site [ion binding]; other site
293826009418	Mg2+ binding site [ion binding]; other site
293826009419	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
293826009420	B12 binding site [chemical binding]; other site
293826009421	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
293826009422	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826009423	FeS/SAM binding site; other site
293826009424	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
293826009425	B12 binding site [chemical binding]; other site
293826009426	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
293826009427	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826009428	FeS/SAM binding site; other site
293826009429	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826009430	S-adenosylmethionine binding site [chemical binding]; other site
293826009431	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
293826009432	B12 binding site [chemical binding]; other site
293826009433	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
293826009434	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826009435	FeS/SAM binding site; other site
293826009436	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
293826009437	aspartate aminotransferase; Provisional; Region: PRK05764
293826009438	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
293826009439	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826009440	homodimer interface [polypeptide binding]; other site
293826009441	catalytic residue [active]
293826009442	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
293826009443	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
293826009444	putative RNA binding site [nucleotide binding]; other site
293826009445	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826009446	S-adenosylmethionine binding site [chemical binding]; other site
293826009447	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
293826009448	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
293826009449	CysD dimerization site [polypeptide binding]; other site
293826009450	G1 box; other site
293826009451	putative GEF interaction site [polypeptide binding]; other site
293826009452	GTP/Mg2+ binding site [chemical binding]; other site
293826009453	Switch I region; other site
293826009454	G2 box; other site
293826009455	G3 box; other site
293826009456	Switch II region; other site
293826009457	G4 box; other site
293826009458	G5 box; other site
293826009459	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
293826009460	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
293826009461	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
293826009462	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
293826009463	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
293826009464	Active Sites [active]
293826009465	Ferredoxin [Energy production and conversion]; Region: COG1146
293826009466	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
293826009467	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
293826009468	L-aspartate oxidase; Provisional; Region: PRK06175
293826009469	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
293826009470	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
293826009471	ligand-binding site [chemical binding]; other site
293826009472	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
293826009473	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
293826009474	transmembrane helices; other site
293826009475	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
293826009476	precorrin-3B synthase; Region: CobG; TIGR02435
293826009477	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
293826009478	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
293826009479	CPxP  motif; other site
293826009480	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
293826009481	MPN+ (JAMM) motif; other site
293826009482	Zinc-binding site [ion binding]; other site
293826009483	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
293826009484	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
293826009485	ATP binding site [chemical binding]; other site
293826009486	substrate interface [chemical binding]; other site
293826009487	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
293826009488	thiS-thiF/thiG interaction site; other site
293826009489	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
293826009490	putative deacylase active site [active]
293826009491	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
293826009492	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
293826009493	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
293826009494	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
293826009495	WYL domain; Region: WYL; pfam13280
293826009496	OsmC-like protein; Region: OsmC; pfam02566
293826009497	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
293826009498	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
293826009499	tetramer interface [polypeptide binding]; other site
293826009500	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826009501	catalytic residue [active]
293826009502	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
293826009503	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
293826009504	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
293826009505	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
293826009506	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
293826009507	DNA binding site [nucleotide binding]
293826009508	active site
293826009509	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
293826009510	endonuclease III; Region: ENDO3c; smart00478
293826009511	minor groove reading motif; other site
293826009512	helix-hairpin-helix signature motif; other site
293826009513	substrate binding pocket [chemical binding]; other site
293826009514	active site
293826009515	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
293826009516	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
293826009517	active site
293826009518	catalytic residues [active]
293826009519	metal binding site [ion binding]; metal-binding site
293826009520	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
293826009521	dimer interface [polypeptide binding]; other site
293826009522	[2Fe-2S] cluster binding site [ion binding]; other site
293826009523	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
293826009524	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826009525	FeS/SAM binding site; other site
293826009526	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
293826009527	Nitrogenase_nifN_2: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_2; cd03466
293826009528	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
293826009529	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
293826009530	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
293826009531	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
293826009532	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
293826009533	MoFe protein beta/alpha subunit interactions; other site
293826009534	Beta subunit P cluster binding residues; other site
293826009535	MoFe protein beta subunit/Fe protein contacts; other site
293826009536	MoFe protein dimer/ dimer interactions; other site
293826009537	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
293826009538	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
293826009539	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
293826009540	Nitrogen regulatory protein P-II; Region: P-II; smart00938
293826009541	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
293826009542	Nitrogen regulatory protein P-II; Region: P-II; smart00938
293826009543	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
293826009544	nitrogenase iron protein; Region: nifH; TIGR01287
293826009545	Nucleotide-binding sites [chemical binding]; other site
293826009546	Walker A motif; other site
293826009547	Switch I region of nucleotide binding site; other site
293826009548	Fe4S4 binding sites [ion binding]; other site
293826009549	Switch II region of nucleotide binding site; other site
293826009550	AAA domain; Region: AAA_31; pfam13614
293826009551	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
293826009552	Mg binding site [ion binding]; other site
293826009553	nucleotide binding site [chemical binding]; other site
293826009554	putative protofilament interface [polypeptide binding]; other site
293826009555	DctM-like transporters; Region: DctM; pfam06808
293826009556	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
293826009557	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
293826009558	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
293826009559	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
293826009560	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
293826009561	Response regulator receiver domain; Region: Response_reg; pfam00072
293826009562	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826009563	active site
293826009564	phosphorylation site [posttranslational modification]
293826009565	intermolecular recognition site; other site
293826009566	dimerization interface [polypeptide binding]; other site
293826009567	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
293826009568	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826009569	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826009570	Cupin domain; Region: Cupin_2; pfam07883
293826009571	Sensory domain found in PocR; Region: PocR; pfam10114
293826009572	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
293826009573	Histidine kinase; Region: His_kinase; pfam06580
293826009574	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826009575	ATP binding site [chemical binding]; other site
293826009576	Mg2+ binding site [ion binding]; other site
293826009577	G-X-G motif; other site
293826009578	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
293826009579	Putative glucoamylase; Region: Glycoamylase; pfam10091
293826009580	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
293826009581	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
293826009582	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
293826009583	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
293826009584	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
293826009585	active site
293826009586	Substrate binding site; other site
293826009587	Mg++ binding site; other site
293826009588	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
293826009589	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
293826009590	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
293826009591	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
293826009592	Peptidase family M28; Region: Peptidase_M28; pfam04389
293826009593	metal binding site [ion binding]; metal-binding site
293826009594	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_7; cd06244
293826009595	putative active site [active]
293826009596	Zn binding site [ion binding]; other site
293826009597	S-layer homology domain; Region: SLH; pfam00395
293826009598	S-layer homology domain; Region: SLH; pfam00395
293826009599	S-layer homology domain; Region: SLH; pfam00395
293826009600	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
293826009601	metal ion-dependent adhesion site (MIDAS); other site
293826009602	MoxR-like ATPases [General function prediction only]; Region: COG0714
293826009603	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
293826009604	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
293826009605	intersubunit interface [polypeptide binding]; other site
293826009606	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
293826009607	histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856
293826009608	active site
293826009609	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
293826009610	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
293826009611	CPxP  motif; other site
293826009612	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
293826009613	FtsX-like permease family; Region: FtsX; pfam02687
293826009614	FtsX-like permease family; Region: FtsX; pfam02687
293826009615	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
293826009616	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
293826009617	Walker A/P-loop; other site
293826009618	ATP binding site [chemical binding]; other site
293826009619	Q-loop/lid; other site
293826009620	ABC transporter signature motif; other site
293826009621	Walker B; other site
293826009622	D-loop; other site
293826009623	H-loop/switch region; other site
293826009624	FtsX-like permease family; Region: FtsX; pfam02687
293826009625	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
293826009626	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
293826009627	Walker A/P-loop; other site
293826009628	ATP binding site [chemical binding]; other site
293826009629	Q-loop/lid; other site
293826009630	ABC transporter signature motif; other site
293826009631	Walker B; other site
293826009632	D-loop; other site
293826009633	H-loop/switch region; other site
293826009634	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826009635	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826009636	ATP binding site [chemical binding]; other site
293826009637	Mg2+ binding site [ion binding]; other site
293826009638	G-X-G motif; other site
293826009639	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826009640	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826009641	active site
293826009642	phosphorylation site [posttranslational modification]
293826009643	intermolecular recognition site; other site
293826009644	dimerization interface [polypeptide binding]; other site
293826009645	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826009646	DNA binding site [nucleotide binding]
293826009647	transposase/IS protein; Provisional; Region: PRK09183
293826009648	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826009649	Walker A motif; other site
293826009650	ATP binding site [chemical binding]; other site
293826009651	Walker B motif; other site
293826009652	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
293826009653	Integrase core domain; Region: rve; pfam00665
293826009654	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
293826009655	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826009656	active site
293826009657	phosphorylation site [posttranslational modification]
293826009658	intermolecular recognition site; other site
293826009659	dimerization interface [polypeptide binding]; other site
293826009660	LytTr DNA-binding domain; Region: LytTR; smart00850
293826009661	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
293826009662	NPCBM/NEW2 domain; Region: NPCBM; cl07060
293826009663	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826009664	ATP binding site [chemical binding]; other site
293826009665	Mg2+ binding site [ion binding]; other site
293826009666	G-X-G motif; other site
293826009667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826009668	ATP binding site [chemical binding]; other site
293826009669	Mg2+ binding site [ion binding]; other site
293826009670	G-X-G motif; other site
293826009671	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
293826009672	SmpB-tmRNA interface; other site
293826009673	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
293826009674	TrkA-C domain; Region: TrkA_C; pfam02080
293826009675	ribonuclease R; Region: RNase_R; TIGR02063
293826009676	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
293826009677	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
293826009678	RNB domain; Region: RNB; pfam00773
293826009679	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
293826009680	RNA binding site [nucleotide binding]; other site
293826009681	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
293826009682	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
293826009683	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
293826009684	Preprotein translocase SecG subunit; Region: SecG; cl09123
293826009685	enolase; Provisional; Region: eno; PRK00077
293826009686	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
293826009687	dimer interface [polypeptide binding]; other site
293826009688	metal binding site [ion binding]; metal-binding site
293826009689	substrate binding pocket [chemical binding]; other site
293826009690	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
293826009691	phosphoglyceromutase; Provisional; Region: PRK05434
293826009692	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
293826009693	triosephosphate isomerase; Provisional; Region: PRK14565
293826009694	substrate binding site [chemical binding]; other site
293826009695	dimer interface [polypeptide binding]; other site
293826009696	catalytic triad [active]
293826009697	Phosphoglycerate kinase; Region: PGK; pfam00162
293826009698	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
293826009699	substrate binding site [chemical binding]; other site
293826009700	hinge regions; other site
293826009701	ADP binding site [chemical binding]; other site
293826009702	catalytic site [active]
293826009703	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
293826009704	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
293826009705	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
293826009706	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
293826009707	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
293826009708	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
293826009709	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
293826009710	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
293826009711	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
293826009712	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
293826009713	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
293826009714	TM-ABC transporter signature motif; other site
293826009715	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
293826009716	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
293826009717	TM-ABC transporter signature motif; other site
293826009718	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
293826009719	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826009720	Walker A/P-loop; other site
293826009721	ATP binding site [chemical binding]; other site
293826009722	Q-loop/lid; other site
293826009723	ABC transporter signature motif; other site
293826009724	Walker B; other site
293826009725	D-loop; other site
293826009726	H-loop/switch region; other site
293826009727	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
293826009728	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
293826009729	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826009730	FeS/SAM binding site; other site
293826009731	glycine radical enzyme, YjjI family; Region: glycyl_YjjI; TIGR04040
293826009732	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
293826009733	ligand binding site [chemical binding]; other site
293826009734	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
293826009735	Fatty acid synthesis protein; Region: FA_synthesis; cl17261
293826009736	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
293826009737	active site
293826009738	glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917
293826009739	selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918
293826009740	glycine/sarcosine/betaine reductase complex protein A; Reviewed; Region: PRK13265
293826009741	Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338
293826009742	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
293826009743	catalytic residues [active]
293826009744	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
293826009745	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
293826009746	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
293826009747	ATP-sulfurylase; Region: ATP-sulfurylase; pfam01747
293826009748	EDD domain protein, DegV family; Region: DegV; TIGR00762
293826009749	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
293826009750	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
293826009751	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
293826009752	Domain of unknown function (DUF2382); Region: DUF2382; cl01590
293826009753	putative oxidoreductase; Provisional; Region: PRK11579
293826009754	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
293826009755	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
293826009756	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
293826009757	Uncharacterized conserved protein [Function unknown]; Region: COG4198
293826009758	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
293826009759	Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303
293826009760	putative ligand binding site [chemical binding]; other site
293826009761	NAD binding site [chemical binding]; other site
293826009762	dimerization interface [polypeptide binding]; other site
293826009763	catalytic site [active]
293826009764	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
293826009765	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
293826009766	catalytic residue [active]
293826009767	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
293826009768	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
293826009769	active site
293826009770	HIGH motif; other site
293826009771	dimer interface [polypeptide binding]; other site
293826009772	KMSKS motif; other site
293826009773	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
293826009774	RNA binding surface [nucleotide binding]; other site
293826009775	EDD domain protein, DegV family; Region: DegV; TIGR00762
293826009776	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
293826009777	Uncharacterized conserved protein [Function unknown]; Region: COG2006
293826009778	Domain of unknown function (DUF362); Region: DUF362; pfam04015
293826009779	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
293826009780	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
293826009781	active site
293826009782	metal binding site [ion binding]; metal-binding site
293826009783	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
293826009784	S-layer homology domain; Region: SLH; pfam00395
293826009785	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
293826009786	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
293826009787	active site
293826009788	metal binding site [ion binding]; metal-binding site
293826009789	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
293826009790	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826009791	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
293826009792	Uncharacterized conserved protein [Function unknown]; Region: COG2006
293826009793	Domain of unknown function (DUF362); Region: DUF362; pfam04015
293826009794	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
293826009795	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
293826009796	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
293826009797	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
293826009798	active site
293826009799	motif I; other site
293826009800	motif II; other site
293826009801	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
293826009802	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
293826009803	metal binding site 2 [ion binding]; metal-binding site
293826009804	putative DNA binding helix; other site
293826009805	metal binding site 1 [ion binding]; metal-binding site
293826009806	dimer interface [polypeptide binding]; other site
293826009807	structural Zn2+ binding site [ion binding]; other site
293826009808	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
293826009809	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
293826009810	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826009811	homodimer interface [polypeptide binding]; other site
293826009812	catalytic residue [active]
293826009813	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
293826009814	cobyric acid synthase; Provisional; Region: PRK00784
293826009815	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
293826009816	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
293826009817	catalytic triad [active]
293826009818	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
293826009819	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
293826009820	Walker A/P-loop; other site
293826009821	ATP binding site [chemical binding]; other site
293826009822	Q-loop/lid; other site
293826009823	ABC transporter signature motif; other site
293826009824	Walker B; other site
293826009825	D-loop; other site
293826009826	H-loop/switch region; other site
293826009827	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
293826009828	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
293826009829	ABC-ATPase subunit  interface; other site
293826009830	dimer interface [polypeptide binding]; other site
293826009831	putative PBP binding regions; other site
293826009832	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
293826009833	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
293826009834	cobalamin binding residues [chemical binding]; other site
293826009835	putative BtuC binding residues; other site
293826009836	dimer interface [polypeptide binding]; other site
293826009837	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
293826009838	catalytic core [active]
293826009839	cobalamin synthase; Reviewed; Region: cobS; PRK00235
293826009840	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
293826009841	homodimer interface [polypeptide binding]; other site
293826009842	Walker A motif; other site
293826009843	ATP binding site [chemical binding]; other site
293826009844	hydroxycobalamin binding site [chemical binding]; other site
293826009845	Walker B motif; other site
293826009846	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
293826009847	homotrimer interface [polypeptide binding]; other site
293826009848	Walker A motif; other site
293826009849	GTP binding site [chemical binding]; other site
293826009850	Walker B motif; other site
293826009851	PGAP1-like protein; Region: PGAP1; pfam07819
293826009852	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
293826009853	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
293826009854	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
293826009855	VanW like protein; Region: VanW; pfam04294
293826009856	G5 domain; Region: G5; pfam07501
293826009857	Cell division protein FtsA; Region: FtsA; smart00842
293826009858	Cell division protein FtsA; Region: FtsA; pfam14450
293826009859	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
293826009860	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
293826009861	minor groove reading motif; other site
293826009862	helix-hairpin-helix signature motif; other site
293826009863	substrate binding pocket [chemical binding]; other site
293826009864	active site
293826009865	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
293826009866	Protein of unknown function (DUF503); Region: DUF503; pfam04456
293826009867	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
293826009868	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
293826009869	HlyD family secretion protein; Region: HlyD_3; pfam13437
293826009870	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
293826009871	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
293826009872	Catalytic site [active]
293826009873	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
293826009874	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
293826009875	substrate-cofactor binding pocket; other site
293826009876	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826009877	catalytic residue [active]
293826009878	AAA domain; Region: AAA_32; pfam13654
293826009879	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
293826009880	epoxyqueuosine reductase; Region: TIGR00276
293826009881	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
293826009882	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
293826009883	protein binding surface [polypeptide binding]; other site
293826009884	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
293826009885	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
293826009886	Catalytic site [active]
293826009887	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
293826009888	Protein of unknown function (DUF456); Region: DUF456; pfam04306
293826009889	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
293826009890	dimerization interface [polypeptide binding]; other site
293826009891	putative DNA binding site [nucleotide binding]; other site
293826009892	putative Zn2+ binding site [ion binding]; other site
293826009893	Nitroreductase family; Region: Nitroreductase; pfam00881
293826009894	FMN binding site [chemical binding]; other site
293826009895	dimer interface [polypeptide binding]; other site
293826009896	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
293826009897	dimer interface [polypeptide binding]; other site
293826009898	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
293826009899	glutaminase A; Region: Gln_ase; TIGR03814
293826009900	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
293826009901	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
293826009902	active site
293826009903	FOG: CBS domain [General function prediction only]; Region: COG0517
293826009904	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
293826009905	gamma-glutamyl kinase; Provisional; Region: PRK05429
293826009906	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
293826009907	nucleotide binding site [chemical binding]; other site
293826009908	homotetrameric interface [polypeptide binding]; other site
293826009909	putative phosphate binding site [ion binding]; other site
293826009910	putative allosteric binding site; other site
293826009911	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
293826009912	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
293826009913	putative catalytic cysteine [active]
293826009914	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
293826009915	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
293826009916	Catalytic site [active]
293826009917	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
293826009918	YceG-like family; Region: YceG; pfam02618
293826009919	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
293826009920	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
293826009921	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
293826009922	motif II; other site
293826009923	Protease prsW family; Region: PrsW-protease; pfam13367
293826009924	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
293826009925	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
293826009926	dimanganese center [ion binding]; other site
293826009927	CotJB protein; Region: CotJB; pfam12652
293826009928	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
293826009929	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
293826009930	active site
293826009931	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
293826009932	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826009933	Coenzyme A binding pocket [chemical binding]; other site
293826009934	Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region; Region: Gly_acyl_tr_C; pfam08444
293826009935	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
293826009936	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
293826009937	Ligand Binding Site [chemical binding]; other site
293826009938	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
293826009939	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
293826009940	Walker A/P-loop; other site
293826009941	ATP binding site [chemical binding]; other site
293826009942	Q-loop/lid; other site
293826009943	ABC transporter signature motif; other site
293826009944	Walker B; other site
293826009945	D-loop; other site
293826009946	H-loop/switch region; other site
293826009947	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
293826009948	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826009949	dimer interface [polypeptide binding]; other site
293826009950	conserved gate region; other site
293826009951	putative PBP binding loops; other site
293826009952	ABC-ATPase subunit interface; other site
293826009953	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
293826009954	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
293826009955	substrate binding pocket [chemical binding]; other site
293826009956	membrane-bound complex binding site; other site
293826009957	hinge residues; other site
293826009958	Bacterial SH3 domain; Region: SH3_3; cl17532
293826009959	Bacterial SH3 domain; Region: SH3_3; pfam08239
293826009960	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
293826009961	NlpC/P60 family; Region: NLPC_P60; pfam00877
293826009962	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
293826009963	catalytic triad [active]
293826009964	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
293826009965	putative metal binding site [ion binding]; other site
293826009966	putative dimer interface [polypeptide binding]; other site
293826009967	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
293826009968	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
293826009969	S-layer homology domain; Region: SLH; pfam00395
293826009970	S-layer homology domain; Region: SLH; pfam00395
293826009971	S-layer homology domain; Region: SLH; pfam00395
293826009972	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
293826009973	TRAM domain; Region: TRAM; cl01282
293826009974	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826009975	S-adenosylmethionine binding site [chemical binding]; other site
293826009976	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
293826009977	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
293826009978	RNA binding surface [nucleotide binding]; other site
293826009979	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
293826009980	active site
293826009981	uracil binding [chemical binding]; other site
293826009982	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
293826009983	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
293826009984	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
293826009985	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
293826009986	intersubunit interface [polypeptide binding]; other site
293826009987	active site
293826009988	zinc binding site [ion binding]; other site
293826009989	Na+ binding site [ion binding]; other site
293826009990	Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393
293826009991	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
293826009992	putative active site [active]
293826009993	putative metal binding site [ion binding]; other site
293826009994	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
293826009995	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
293826009996	synthetase active site [active]
293826009997	NTP binding site [chemical binding]; other site
293826009998	metal binding site [ion binding]; metal-binding site
293826009999	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
293826010000	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
293826010001	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
293826010002	Rdx family; Region: Rdx; pfam10262
293826010003	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
293826010004	Major Facilitator Superfamily; Region: MFS_1; pfam07690
293826010005	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
293826010006	putative substrate translocation pore; other site
293826010007	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
293826010008	Ligand Binding Site [chemical binding]; other site
293826010009	S-layer homology domain; Region: SLH; pfam00395
293826010010	S-layer homology domain; Region: SLH; pfam00395
293826010011	S-layer homology domain; Region: SLH; pfam00395
293826010012	Glyco_18 domain; Region: Glyco_18; smart00636
293826010013	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
293826010014	active site
293826010015	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826010016	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
293826010017	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826010018	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
293826010019	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
293826010020	Domain of unknown function (DUF378); Region: DUF378; pfam04070
293826010021	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
293826010022	Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155
293826010023	putative ligand binding site [chemical binding]; other site
293826010024	NAD binding site [chemical binding]; other site
293826010025	catalytic site [active]
293826010026	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826010027	Zn2+ binding site [ion binding]; other site
293826010028	Mg2+ binding site [ion binding]; other site
293826010029	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
293826010030	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
293826010031	G1 box; other site
293826010032	putative GEF interaction site [polypeptide binding]; other site
293826010033	GTP/Mg2+ binding site [chemical binding]; other site
293826010034	Switch I region; other site
293826010035	G2 box; other site
293826010036	G3 box; other site
293826010037	Switch II region; other site
293826010038	G4 box; other site
293826010039	G5 box; other site
293826010040	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
293826010041	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
293826010042	EamA-like transporter family; Region: EamA; pfam00892
293826010043	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
293826010044	EamA-like transporter family; Region: EamA; pfam00892
293826010045	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
293826010046	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
293826010047	FMN binding site [chemical binding]; other site
293826010048	dimer interface [polypeptide binding]; other site
293826010049	methionine sulfoxide reductase A; Provisional; Region: PRK14054
293826010050	Tetratricopeptide repeat; Region: TPR_12; pfam13424
293826010051	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826010052	binding surface
293826010053	TPR motif; other site
293826010054	TPR repeat; Region: TPR_11; pfam13414
293826010055	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826010056	binding surface
293826010057	TPR motif; other site
293826010058	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
293826010059	binding surface
293826010060	TPR motif; other site
293826010061	Tetratricopeptide repeat; Region: TPR_12; pfam13424
293826010062	GAF domain; Region: GAF_2; pfam13185
293826010063	GAF domain; Region: GAF_3; pfam13492
293826010064	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
293826010065	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
293826010066	metal binding site [ion binding]; metal-binding site
293826010067	active site
293826010068	I-site; other site
293826010069	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
293826010070	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826010071	Zn2+ binding site [ion binding]; other site
293826010072	Mg2+ binding site [ion binding]; other site
293826010073	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
293826010074	catalytic residue [active]
293826010075	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826010076	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
293826010077	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
293826010078	Coenzyme A binding pocket [chemical binding]; other site
293826010079	Putative amidase domain; Region: Amidase_6; pfam12671
293826010080	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
293826010081	cystathionine beta-lyase; Provisional; Region: PRK08064
293826010082	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
293826010083	homodimer interface [polypeptide binding]; other site
293826010084	substrate-cofactor binding pocket; other site
293826010085	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826010086	catalytic residue [active]
293826010087	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
293826010088	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
293826010089	homodimer interface [polypeptide binding]; other site
293826010090	substrate-cofactor binding pocket; other site
293826010091	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826010092	catalytic residue [active]
293826010093	Homoserine O-succinyltransferase; Region: HTS; pfam04204
293826010094	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
293826010095	proposed active site lysine [active]
293826010096	conserved cys residue [active]
293826010097	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
293826010098	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
293826010099	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
293826010100	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
293826010101	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
293826010102	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
293826010103	ATP-grasp domain; Region: ATP-grasp_4; cl17255
293826010104	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826010105	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826010106	dimer interface [polypeptide binding]; other site
293826010107	phosphorylation site [posttranslational modification]
293826010108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826010109	ATP binding site [chemical binding]; other site
293826010110	Mg2+ binding site [ion binding]; other site
293826010111	G-X-G motif; other site
293826010112	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826010113	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826010114	active site
293826010115	phosphorylation site [posttranslational modification]
293826010116	intermolecular recognition site; other site
293826010117	dimerization interface [polypeptide binding]; other site
293826010118	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826010119	DNA binding site [nucleotide binding]
293826010120	NRDE protein; Region: NRDE; pfam05742
293826010121	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
293826010122	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
293826010123	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
293826010124	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
293826010125	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826010126	active site
293826010127	phosphorylation site [posttranslational modification]
293826010128	intermolecular recognition site; other site
293826010129	dimerization interface [polypeptide binding]; other site
293826010130	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
293826010131	DNA binding residues [nucleotide binding]
293826010132	dimerization interface [polypeptide binding]; other site
293826010133	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
293826010134	Histidine kinase; Region: HisKA_3; pfam07730
293826010135	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826010136	ATP binding site [chemical binding]; other site
293826010137	Mg2+ binding site [ion binding]; other site
293826010138	G-X-G motif; other site
293826010139	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
293826010140	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
293826010141	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826010142	Walker A/P-loop; other site
293826010143	ATP binding site [chemical binding]; other site
293826010144	Q-loop/lid; other site
293826010145	ABC transporter signature motif; other site
293826010146	Walker B; other site
293826010147	D-loop; other site
293826010148	H-loop/switch region; other site
293826010149	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
293826010150	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
293826010151	gating phenylalanine in ion channel; other site
293826010152	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
293826010153	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
293826010154	ligand binding site [chemical binding]; other site
293826010155	flexible hinge region; other site
293826010156	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
293826010157	putative switch regulator; other site
293826010158	non-specific DNA interactions [nucleotide binding]; other site
293826010159	DNA binding site [nucleotide binding]
293826010160	sequence specific DNA binding site [nucleotide binding]; other site
293826010161	putative cAMP binding site [chemical binding]; other site
293826010162	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
293826010163	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
293826010164	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
293826010165	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
293826010166	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
293826010167	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
293826010168	putative Cl- selectivity filter; other site
293826010169	putative pore gating glutamate residue; other site
293826010170	Predicted membrane protein [Function unknown]; Region: COG2323
293826010171	DctM-like transporters; Region: DctM; pfam06808
293826010172	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
293826010173	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
293826010174	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
293826010175	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
293826010176	putative hydrolase; Validated; Region: PRK09248
293826010177	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
293826010178	active site
293826010179	Nitroreductase family; Region: Nitroreductase; pfam00881
293826010180	FMN binding site [chemical binding]; other site
293826010181	dimer interface [polypeptide binding]; other site
293826010182	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
293826010183	dimer interface [polypeptide binding]; other site
293826010184	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
293826010185	dimer interface [polypeptide binding]; other site
293826010186	catalytic triad [active]
293826010187	peroxidatic and resolving cysteines [active]
293826010188	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
293826010189	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
293826010190	metal binding site [ion binding]; metal-binding site
293826010191	dimer interface [polypeptide binding]; other site
293826010192	Predicted membrane protein [Function unknown]; Region: COG2855
293826010193	conserved hypothetical protein; Region: TIGR03833
293826010194	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
293826010195	EamA-like transporter family; Region: EamA; pfam00892
293826010196	EamA-like transporter family; Region: EamA; pfam00892
293826010197	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
293826010198	hypothetical protein; Provisional; Region: PRK04164
293826010199	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
293826010200	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
293826010201	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
293826010202	ATP-grasp domain; Region: ATP-grasp_4; cl17255
293826010203	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
293826010204	metal binding site [ion binding]; metal-binding site
293826010205	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
293826010206	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
293826010207	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
293826010208	FAD binding domain; Region: FAD_binding_4; pfam01565
293826010209	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
293826010210	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
293826010211	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
293826010212	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
293826010213	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
293826010214	Ligand binding site [chemical binding]; other site
293826010215	Electron transfer flavoprotein domain; Region: ETF; pfam01012
293826010216	Transcriptional regulators [Transcription]; Region: FadR; COG2186
293826010217	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826010218	DNA-binding site [nucleotide binding]; DNA binding site
293826010219	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
293826010220	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
293826010221	L-lactate permease; Region: Lactate_perm; cl00701
293826010222	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
293826010223	Protein of unknown function (DUF1271); Region: DUF1271; pfam06902
293826010224	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
293826010225	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
293826010226	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
293826010227	substrate binding pocket [chemical binding]; other site
293826010228	membrane-bound complex binding site; other site
293826010229	hinge residues; other site
293826010230	PAS domain S-box; Region: sensory_box; TIGR00229
293826010231	PAS domain; Region: PAS; smart00091
293826010232	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
293826010233	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
293826010234	metal binding site [ion binding]; metal-binding site
293826010235	active site
293826010236	I-site; other site
293826010237	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
293826010238	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826010239	Zn2+ binding site [ion binding]; other site
293826010240	Mg2+ binding site [ion binding]; other site
293826010241	Cache domain; Region: Cache_1; pfam02743
293826010242	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
293826010243	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826010244	dimer interface [polypeptide binding]; other site
293826010245	putative CheW interface [polypeptide binding]; other site
293826010246	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
293826010247	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
293826010248	ATP binding site [chemical binding]; other site
293826010249	Mg++ binding site [ion binding]; other site
293826010250	motif III; other site
293826010251	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
293826010252	nucleotide binding region [chemical binding]; other site
293826010253	ATP-binding site [chemical binding]; other site
293826010254	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
293826010255	RNA binding site [nucleotide binding]; other site
293826010256	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
293826010257	Phosphotransferase enzyme family; Region: APH; pfam01636
293826010258	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
293826010259	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
293826010260	L-fuculose phosphate aldolase; Provisional; Region: PRK06833
293826010261	intersubunit interface [polypeptide binding]; other site
293826010262	active site
293826010263	Zn2+ binding site [ion binding]; other site
293826010264	Sensory domain found in PocR; Region: PocR; pfam10114
293826010265	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
293826010266	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
293826010267	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826010268	dimer interface [polypeptide binding]; other site
293826010269	putative CheW interface [polypeptide binding]; other site
293826010270	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
293826010271	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
293826010272	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
293826010273	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
293826010274	Walker A/P-loop; other site
293826010275	ATP binding site [chemical binding]; other site
293826010276	Q-loop/lid; other site
293826010277	ABC transporter signature motif; other site
293826010278	Walker B; other site
293826010279	D-loop; other site
293826010280	H-loop/switch region; other site
293826010281	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
293826010282	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
293826010283	P-loop; other site
293826010284	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
293826010285	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
293826010286	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
293826010287	ACS interaction site; other site
293826010288	CODH interaction site; other site
293826010289	cubane metal cluster (B-cluster) [ion binding]; other site
293826010290	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
293826010291	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
293826010292	4Fe-4S binding domain; Region: Fer4; cl02805
293826010293	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
293826010294	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
293826010295	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
293826010296	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826010297	Walker A motif; other site
293826010298	ATP binding site [chemical binding]; other site
293826010299	Walker B motif; other site
293826010300	arginine finger; other site
293826010301	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
293826010302	oligoendopeptidase F; Region: pepF; TIGR00181
293826010303	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
293826010304	active site
293826010305	Zn binding site [ion binding]; other site
293826010306	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
293826010307	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
293826010308	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
293826010309	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
293826010310	H+ Antiporter protein; Region: 2A0121; TIGR00900
293826010311	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
293826010312	putative substrate translocation pore; other site
293826010313	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
293826010314	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
293826010315	Walker A/P-loop; other site
293826010316	ATP binding site [chemical binding]; other site
293826010317	Q-loop/lid; other site
293826010318	ABC transporter signature motif; other site
293826010319	Walker B; other site
293826010320	D-loop; other site
293826010321	H-loop/switch region; other site
293826010322	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
293826010323	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
293826010324	ABC-ATPase subunit  interface; other site
293826010325	dimer interface [polypeptide binding]; other site
293826010326	putative PBP binding regions; other site
293826010327	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
293826010328	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
293826010329	ABC-ATPase subunit  interface; other site
293826010330	dimer interface [polypeptide binding]; other site
293826010331	putative PBP binding regions; other site
293826010332	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
293826010333	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
293826010334	intersubunit interface [polypeptide binding]; other site
293826010335	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
293826010336	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826010337	MraW methylase family; Region: Methyltransf_5; cl17771
293826010338	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
293826010339	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
293826010340	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
293826010341	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826010342	dimer interface [polypeptide binding]; other site
293826010343	putative CheW interface [polypeptide binding]; other site
293826010344	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
293826010345	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
293826010346	DEAD/DEAH box helicase; Region: DEAD; pfam00270
293826010347	ATP binding site [chemical binding]; other site
293826010348	putative Mg++ binding site [ion binding]; other site
293826010349	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
293826010350	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
293826010351	nucleotide binding region [chemical binding]; other site
293826010352	ATP-binding site [chemical binding]; other site
293826010353	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
293826010354	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
293826010355	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
293826010356	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
293826010357	putative substrate translocation pore; other site
293826010358	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
293826010359	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
293826010360	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
293826010361	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
293826010362	mannonate dehydratase; Provisional; Region: PRK03906
293826010363	mannonate dehydratase; Region: uxuA; TIGR00695
293826010364	YcxB-like protein; Region: YcxB; pfam14317
293826010365	DctM-like transporters; Region: DctM; pfam06808
293826010366	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
293826010367	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
293826010368	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
293826010369	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
293826010370	Transcriptional regulators [Transcription]; Region: GntR; COG1802
293826010371	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826010372	DNA-binding site [nucleotide binding]; DNA binding site
293826010373	FCD domain; Region: FCD; pfam07729
293826010374	Uncharacterized conserved protein [Function unknown]; Region: COG4279
293826010375	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236
293826010376	SWIM zinc finger; Region: SWIM; pfam04434
293826010377	SNF2 Helicase protein; Region: DUF3670; pfam12419
293826010378	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
293826010379	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
293826010380	ATP binding site [chemical binding]; other site
293826010381	putative Mg++ binding site [ion binding]; other site
293826010382	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
293826010383	nucleotide binding region [chemical binding]; other site
293826010384	ATP-binding site [chemical binding]; other site
293826010385	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
293826010386	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
293826010387	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
293826010388	N- and C-terminal domain interface [polypeptide binding]; other site
293826010389	D-xylulose kinase; Region: XylB; TIGR01312
293826010390	active site
293826010391	MgATP binding site [chemical binding]; other site
293826010392	catalytic site [active]
293826010393	metal binding site [ion binding]; metal-binding site
293826010394	xylulose binding site [chemical binding]; other site
293826010395	homodimer interface [polypeptide binding]; other site
293826010396	putative DNA binding site [nucleotide binding]; other site
293826010397	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
293826010398	putative Zn2+ binding site [ion binding]; other site
293826010399	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
293826010400	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
293826010401	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
293826010402	xylose isomerase; Provisional; Region: PRK05474
293826010403	xylose isomerase; Region: xylose_isom_A; TIGR02630
293826010404	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
293826010405	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
293826010406	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
293826010407	TM-ABC transporter signature motif; other site
293826010408	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
293826010409	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
293826010410	Walker A/P-loop; other site
293826010411	ATP binding site [chemical binding]; other site
293826010412	Q-loop/lid; other site
293826010413	ABC transporter signature motif; other site
293826010414	Walker B; other site
293826010415	D-loop; other site
293826010416	H-loop/switch region; other site
293826010417	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
293826010418	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
293826010419	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
293826010420	putative ligand binding site [chemical binding]; other site
293826010421	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
293826010422	active site
293826010423	catalytic residues [active]
293826010424	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
293826010425	Carbohydrate binding domain X2; Region: CBM_X2; pfam03442
293826010426	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
293826010427	Putative Ig domain; Region: He_PIG; pfam05345
293826010428	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
293826010429	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
293826010430	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826010431	active site
293826010432	phosphorylation site [posttranslational modification]
293826010433	intermolecular recognition site; other site
293826010434	dimerization interface [polypeptide binding]; other site
293826010435	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
293826010436	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
293826010437	Histidine kinase; Region: His_kinase; pfam06580
293826010438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826010439	ATP binding site [chemical binding]; other site
293826010440	Mg2+ binding site [ion binding]; other site
293826010441	G-X-G motif; other site
293826010442	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
293826010443	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
293826010444	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
293826010445	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
293826010446	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826010447	Walker A/P-loop; other site
293826010448	ATP binding site [chemical binding]; other site
293826010449	Q-loop/lid; other site
293826010450	ABC transporter signature motif; other site
293826010451	Walker B; other site
293826010452	D-loop; other site
293826010453	H-loop/switch region; other site
293826010454	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
293826010455	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
293826010456	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826010457	Walker A/P-loop; other site
293826010458	ATP binding site [chemical binding]; other site
293826010459	Q-loop/lid; other site
293826010460	ABC transporter signature motif; other site
293826010461	Walker B; other site
293826010462	D-loop; other site
293826010463	H-loop/switch region; other site
293826010464	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
293826010465	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826010466	Putative zinc-finger; Region: zf-HC2; pfam13490
293826010467	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
293826010468	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826010469	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826010470	DNA binding residues [nucleotide binding]
293826010471	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
293826010472	YoaP-like; Region: YoaP; pfam14268
293826010473	Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674
293826010474	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
293826010475	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
293826010476	Probable transposase; Region: OrfB_IS605; pfam01385
293826010477	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
293826010478	Transposase IS200 like; Region: Y1_Tnp; pfam01797
293826010479	HTH domain; Region: HTH_11; pfam08279
293826010480	Transposase [DNA replication, recombination, and repair]; Region: COG5421
293826010481	Transposase IS200 like; Region: Y1_Tnp; cl00848
293826010482	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
293826010483	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
293826010484	Hexamer interface [polypeptide binding]; other site
293826010485	Putative hexagonal pore residue; other site
293826010486	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
293826010487	Propanediol utilisation protein PduL; Region: PduL; pfam06130
293826010488	Propanediol utilisation protein PduL; Region: PduL; pfam06130
293826010489	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
293826010490	putative catalytic cysteine [active]
293826010491	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
293826010492	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
293826010493	Hexamer interface [polypeptide binding]; other site
293826010494	Hexagonal pore residue; other site
293826010495	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
293826010496	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
293826010497	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
293826010498	putative hexamer interface [polypeptide binding]; other site
293826010499	putative hexagonal pore; other site
293826010500	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
293826010501	putative hexamer interface [polypeptide binding]; other site
293826010502	putative hexagonal pore; other site
293826010503	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
293826010504	SLBB domain; Region: SLBB; pfam10531
293826010505	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
293826010506	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
293826010507	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
293826010508	Hexamer/Pentamer interface [polypeptide binding]; other site
293826010509	central pore; other site
293826010510	Bacterial Micro-Compartment (BMC)-like domain 2; Region: BMC_like_2; cd07055
293826010511	putative hexamer interface [polypeptide binding]; other site
293826010512	putative hexagonal pore; other site
293826010513	ethanolamine utilization protein EutJ; Provisional; Region: PRK15080
293826010514	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
293826010515	nucleotide binding site [chemical binding]; other site
293826010516	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
293826010517	nucleotide binding site [chemical binding]; other site
293826010518	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
293826010519	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
293826010520	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
293826010521	putative hexamer interface [polypeptide binding]; other site
293826010522	putative hexagonal pore; other site
293826010523	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
293826010524	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
293826010525	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
293826010526	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
293826010527	dimer interface [polypeptide binding]; other site
293826010528	active site
293826010529	glycine loop; other site
293826010530	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
293826010531	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
293826010532	Hexamer interface [polypeptide binding]; other site
293826010533	Hexagonal pore residue; other site
293826010534	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
293826010535	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
293826010536	Hexamer interface [polypeptide binding]; other site
293826010537	Hexagonal pore residue; other site
293826010538	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
293826010539	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
293826010540	Phosphotransferase enzyme family; Region: APH; pfam01636
293826010541	active site
293826010542	ATP binding site [chemical binding]; other site
293826010543	substrate binding site [chemical binding]; other site
293826010544	dimer interface [polypeptide binding]; other site
293826010545	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
293826010546	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
293826010547	putative active site [active]
293826010548	metal binding site [ion binding]; metal-binding site
293826010549	Histidine kinase; Region: His_kinase; pfam06580
293826010550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826010551	ATP binding site [chemical binding]; other site
293826010552	Mg2+ binding site [ion binding]; other site
293826010553	G-X-G motif; other site
293826010554	Response regulator receiver domain; Region: Response_reg; pfam00072
293826010555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826010556	active site
293826010557	phosphorylation site [posttranslational modification]
293826010558	intermolecular recognition site; other site
293826010559	dimerization interface [polypeptide binding]; other site
293826010560	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826010561	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
293826010562	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826010563	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
293826010564	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826010565	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
293826010566	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826010567	Walker A/P-loop; other site
293826010568	ATP binding site [chemical binding]; other site
293826010569	Q-loop/lid; other site
293826010570	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826010571	ABC transporter signature motif; other site
293826010572	Walker B; other site
293826010573	D-loop; other site
293826010574	H-loop/switch region; other site
293826010575	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826010576	AAA domain; Region: AAA_21; pfam13304
293826010577	Walker A/P-loop; other site
293826010578	ATP binding site [chemical binding]; other site
293826010579	Q-loop/lid; other site
293826010580	ABC transporter signature motif; other site
293826010581	Walker B; other site
293826010582	D-loop; other site
293826010583	H-loop/switch region; other site
293826010584	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
293826010585	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
293826010586	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
293826010587	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
293826010588	transposase/IS protein; Provisional; Region: PRK09183
293826010589	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826010590	Walker A motif; other site
293826010591	ATP binding site [chemical binding]; other site
293826010592	Walker B motif; other site
293826010593	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
293826010594	Integrase core domain; Region: rve; pfam00665
293826010595	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
293826010596	Predicted membrane protein [Function unknown]; Region: COG2119
293826010597	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
293826010598	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
293826010599	FMN-binding domain; Region: FMN_bind; pfam04205
293826010600	FMN-binding domain; Region: FMN_bind; pfam04205
293826010601	hypothetical protein; Validated; Region: PRK07121
293826010602	Predicted oxidoreductase [General function prediction only]; Region: COG3573
293826010603	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
293826010604	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
293826010605	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
293826010606	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
293826010607	Predicted oxidoreductase [General function prediction only]; Region: COG3573
293826010608	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
293826010609	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826010610	ABC transporter; Region: ABC_tran; pfam00005
293826010611	Q-loop/lid; other site
293826010612	ABC transporter signature motif; other site
293826010613	Walker B; other site
293826010614	D-loop; other site
293826010615	H-loop/switch region; other site
293826010616	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826010617	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826010618	dimer interface [polypeptide binding]; other site
293826010619	phosphorylation site [posttranslational modification]
293826010620	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826010621	ATP binding site [chemical binding]; other site
293826010622	Mg2+ binding site [ion binding]; other site
293826010623	G-X-G motif; other site
293826010624	Transcriptional regulator [Transcription]; Region: LysR; COG0583
293826010625	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
293826010626	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
293826010627	dimerization interface [polypeptide binding]; other site
293826010628	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
293826010629	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
293826010630	Cache domain; Region: Cache_1; pfam02743
293826010631	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826010632	dimerization interface [polypeptide binding]; other site
293826010633	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
293826010634	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826010635	dimer interface [polypeptide binding]; other site
293826010636	putative CheW interface [polypeptide binding]; other site
293826010637	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
293826010638	Transposase IS200 like; Region: Y1_Tnp; cl00848
293826010639	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
293826010640	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
293826010641	putative substrate translocation pore; other site
293826010642	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
293826010643	active site
293826010644	Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
293826010645	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
293826010646	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
293826010647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826010648	dimer interface [polypeptide binding]; other site
293826010649	conserved gate region; other site
293826010650	putative PBP binding loops; other site
293826010651	ABC-ATPase subunit interface; other site
293826010652	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
293826010653	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
293826010654	Walker A/P-loop; other site
293826010655	ATP binding site [chemical binding]; other site
293826010656	Q-loop/lid; other site
293826010657	ABC transporter signature motif; other site
293826010658	Walker B; other site
293826010659	D-loop; other site
293826010660	H-loop/switch region; other site
293826010661	NIL domain; Region: NIL; pfam09383
293826010662	Transposase IS200 like; Region: Y1_Tnp; cl00848
293826010663	Winged helix-turn helix; Region: HTH_29; pfam13551
293826010664	Homeodomain-like domain; Region: HTH_32; pfam13565
293826010665	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
293826010666	Penicillinase repressor; Region: Pencillinase_R; cl17580
293826010667	ABC-2 type transporter; Region: ABC2_membrane; cl17235
293826010668	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826010669	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
293826010670	Walker A/P-loop; other site
293826010671	ATP binding site [chemical binding]; other site
293826010672	Q-loop/lid; other site
293826010673	ABC transporter signature motif; other site
293826010674	Walker B; other site
293826010675	D-loop; other site
293826010676	H-loop/switch region; other site
293826010677	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826010678	Walker A/P-loop; other site
293826010679	ATP binding site [chemical binding]; other site
293826010680	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
293826010681	MarR family; Region: MarR_2; cl17246
293826010682	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826010683	Walker A motif; other site
293826010684	ATP binding site [chemical binding]; other site
293826010685	Predicted transcriptional regulators [Transcription]; Region: COG1695
293826010686	Transcriptional regulator PadR-like family; Region: PadR; cl17335
293826010687	Domain of unknown function (DUF303); Region: DUF303; pfam03629
293826010688	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
293826010689	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
293826010690	Helix-turn-helix domain; Region: HTH_18; pfam12833
293826010691	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826010692	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
293826010693	Predicted transcriptional regulators [Transcription]; Region: COG1695
293826010694	Transcriptional regulator PadR-like family; Region: PadR; cl17335
293826010695	Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775
293826010696	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
293826010697	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
293826010698	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
293826010699	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
293826010700	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
293826010701	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
293826010702	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
293826010703	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
293826010704	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
293826010705	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
293826010706	trimer interface [polypeptide binding]; other site
293826010707	active site
293826010708	substrate binding site [chemical binding]; other site
293826010709	CoA binding site [chemical binding]; other site
293826010710	zinc transporter ZupT; Provisional; Region: PRK04201
293826010711	ZIP Zinc transporter; Region: Zip; pfam02535
293826010712	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
293826010713	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
293826010714	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
293826010715	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
293826010716	DNA binding residues [nucleotide binding]
293826010717	dimer interface [polypeptide binding]; other site
293826010718	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
293826010719	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
293826010720	ABC-2 type transporter; Region: ABC2_membrane; cl17235
293826010721	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826010722	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
293826010723	Walker A/P-loop; other site
293826010724	ATP binding site [chemical binding]; other site
293826010725	Q-loop/lid; other site
293826010726	ABC transporter signature motif; other site
293826010727	Walker B; other site
293826010728	D-loop; other site
293826010729	H-loop/switch region; other site
293826010730	DinB superfamily; Region: DinB_2; pfam12867
293826010731	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
293826010732	DNA binding residues [nucleotide binding]
293826010733	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
293826010734	Predicted transcriptional regulators [Transcription]; Region: COG1725
293826010735	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826010736	DNA-binding site [nucleotide binding]; DNA binding site
293826010737	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
293826010738	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
293826010739	Walker A/P-loop; other site
293826010740	ATP binding site [chemical binding]; other site
293826010741	Q-loop/lid; other site
293826010742	ABC transporter signature motif; other site
293826010743	Walker B; other site
293826010744	D-loop; other site
293826010745	H-loop/switch region; other site
293826010746	Membrane protein of unknown function; Region: DUF360; pfam04020
293826010747	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
293826010748	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
293826010749	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
293826010750	active site
293826010751	catalytic triad [active]
293826010752	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
293826010753	FtsX-like permease family; Region: FtsX; pfam02687
293826010754	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
293826010755	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
293826010756	Walker A/P-loop; other site
293826010757	ATP binding site [chemical binding]; other site
293826010758	Q-loop/lid; other site
293826010759	ABC transporter signature motif; other site
293826010760	Walker B; other site
293826010761	D-loop; other site
293826010762	H-loop/switch region; other site
293826010763	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826010764	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
293826010765	dimer interface [polypeptide binding]; other site
293826010766	phosphorylation site [posttranslational modification]
293826010767	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826010768	ATP binding site [chemical binding]; other site
293826010769	Mg2+ binding site [ion binding]; other site
293826010770	G-X-G motif; other site
293826010771	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826010772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826010773	active site
293826010774	phosphorylation site [posttranslational modification]
293826010775	intermolecular recognition site; other site
293826010776	dimerization interface [polypeptide binding]; other site
293826010777	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826010778	DNA binding site [nucleotide binding]
293826010779	Uncharacterized conserved protein [Function unknown]; Region: COG3339
293826010780	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
293826010781	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
293826010782	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
293826010783	Catalytic domain of Protein Kinases; Region: PKc; cd00180
293826010784	active site
293826010785	ATP binding site [chemical binding]; other site
293826010786	substrate binding site [chemical binding]; other site
293826010787	activation loop (A-loop); other site
293826010788	Protein of unknown function DUF262; Region: DUF262; pfam03235
293826010789	Uncharacterized conserved protein [Function unknown]; Region: COG1479
293826010790	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
293826010791	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
293826010792	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
293826010793	Integrase core domain; Region: rve; pfam00665
293826010794	transposase/IS protein; Provisional; Region: PRK09183
293826010795	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826010796	Walker A motif; other site
293826010797	ATP binding site [chemical binding]; other site
293826010798	Walker B motif; other site
293826010799	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
293826010800	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826010801	Walker A/P-loop; other site
293826010802	ATP binding site [chemical binding]; other site
293826010803	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
293826010804	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
293826010805	Peptidase family M23; Region: Peptidase_M23; pfam01551
293826010806	PrgI family protein; Region: PrgI; pfam12666
293826010807	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
293826010808	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
293826010809	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
293826010810	ParB-like nuclease domain; Region: ParBc; pfam02195
293826010811	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
293826010812	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
293826010813	P-loop; other site
293826010814	Magnesium ion binding site [ion binding]; other site
293826010815	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
293826010816	Magnesium ion binding site [ion binding]; other site
293826010817	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
293826010818	Sodium Bile acid symporter family; Region: SBF; cl17470
293826010819	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
293826010820	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
293826010821	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
293826010822	motif II; other site
293826010823	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
293826010824	dimerization interface [polypeptide binding]; other site
293826010825	putative DNA binding site [nucleotide binding]; other site
293826010826	putative Zn2+ binding site [ion binding]; other site
293826010827	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
293826010828	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826010829	non-specific DNA binding site [nucleotide binding]; other site
293826010830	salt bridge; other site
293826010831	sequence-specific DNA binding site [nucleotide binding]; other site
293826010832	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
293826010833	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
293826010834	catalytic residues [active]
293826010835	catalytic nucleophile [active]
293826010836	Recombinase; Region: Recombinase; pfam07508
293826010837	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
293826010838	Recombinase; Region: Recombinase; pfam07508
293826010839	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
293826010840	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
293826010841	catalytic residues [active]
293826010842	catalytic nucleophile [active]
293826010843	Recombinase; Region: Recombinase; pfam07508
293826010844	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
293826010845	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642
293826010846	active site
293826010847	DNA binding site [nucleotide binding]
293826010848	catalytic site [active]
293826010849	NUMOD4 motif; Region: NUMOD4; pfam07463
293826010850	HNH endonuclease; Region: HNH_3; pfam13392
293826010851	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
293826010852	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
293826010853	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
293826010854	amidase catalytic site [active]
293826010855	Zn binding residues [ion binding]; other site
293826010856	substrate binding site [chemical binding]; other site
293826010857	Sporulation related domain; Region: SPOR; pfam05036
293826010858	Holin family; Region: Phage_holin_4; pfam05105
293826010859	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
293826010860	Myosin tail; Region: Myosin_tail_1; pfam01576
293826010861	Cytochrome c552; Region: Cytochrom_C552; pfam02335
293826010862	Phage-related protein [Function unknown]; Region: COG5412
293826010863	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
293826010864	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
293826010865	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
293826010866	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
293826010867	oligomerization interface [polypeptide binding]; other site
293826010868	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
293826010869	Phage capsid family; Region: Phage_capsid; pfam05065
293826010870	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
293826010871	oligomer interface [polypeptide binding]; other site
293826010872	active site residues [active]
293826010873	Phage portal protein; Region: Phage_portal; pfam04860
293826010874	Phage-related protein [Function unknown]; Region: COG4695
293826010875	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
293826010876	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
293826010877	ParB-like nuclease domain; Region: ParBc; pfam02195
293826010878	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
293826010879	DNA methylase; Region: N6_N4_Mtase; pfam01555
293826010880	S-adenosylmethionine synthetase; Provisional; Region: PRK12459
293826010881	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
293826010882	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
293826010883	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
293826010884	Phage terminase, small subunit; Region: Terminase_4; cl01525
293826010885	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
293826010886	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
293826010887	active site
293826010888	putative active site [active]
293826010889	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
293826010890	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
293826010891	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
293826010892	putative Mg++ binding site [ion binding]; other site
293826010893	MYM-type Zinc finger with FCS sequence motif; Region: zf-FCS; pfam06467
293826010894	HNH endonuclease; Region: HNH_3; pfam13392
293826010895	VRR-NUC domain; Region: VRR_NUC; pfam08774
293826010896	Virulence-associated protein E; Region: VirE; pfam05272
293826010897	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646
293826010898	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
293826010899	Protein of unknown function DUF45; Region: DUF45; pfam01863
293826010900	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
293826010901	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
293826010902	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
293826010903	ATP binding site [chemical binding]; other site
293826010904	putative Mg++ binding site [ion binding]; other site
293826010905	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
293826010906	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
293826010907	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
293826010908	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
293826010909	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
293826010910	HsdM N-terminal domain; Region: HsdM_N; pfam12161
293826010911	Methyltransferase domain; Region: Methyltransf_26; pfam13659
293826010912	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
293826010913	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
293826010914	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
293826010915	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826010916	S-adenosylmethionine binding site [chemical binding]; other site
293826010917	Sporulation and spore germination; Region: Germane; pfam10646
293826010918	Sporulation and spore germination; Region: Germane; smart00909
293826010919	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
293826010920	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
293826010921	active site
293826010922	catalytic tetrad [active]
293826010923	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
293826010924	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
293826010925	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
293826010926	active site
293826010927	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
293826010928	dimer interface [polypeptide binding]; other site
293826010929	[2Fe-2S] cluster binding site [ion binding]; other site
293826010930	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
293826010931	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
293826010932	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
293826010933	Putative Fe-S cluster; Region: FeS; cl17515
293826010934	PAS domain; Region: PAS; smart00091
293826010935	pyruvate kinase; Provisional; Region: PRK06354
293826010936	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
293826010937	domain interfaces; other site
293826010938	active site
293826010939	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
293826010940	6-phosphofructokinase; Provisional; Region: PRK03202
293826010941	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
293826010942	active site
293826010943	ADP/pyrophosphate binding site [chemical binding]; other site
293826010944	dimerization interface [polypeptide binding]; other site
293826010945	allosteric effector site; other site
293826010946	fructose-1,6-bisphosphate binding site; other site
293826010947	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
293826010948	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
293826010949	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
293826010950	active site
293826010951	PHP Thumb interface [polypeptide binding]; other site
293826010952	metal binding site [ion binding]; metal-binding site
293826010953	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
293826010954	generic binding surface II; other site
293826010955	generic binding surface I; other site
293826010956	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
293826010957	AAA ATPase domain; Region: AAA_16; pfam13191
293826010958	Predicted ATPase [General function prediction only]; Region: COG3899
293826010959	Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643
293826010960	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
293826010961	Formiminotransferase domain; Region: FTCD; pfam02971
293826010962	urocanate hydratase; Provisional; Region: PRK05414
293826010963	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
293826010964	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
293826010965	Substrate-binding site [chemical binding]; other site
293826010966	Substrate specificity [chemical binding]; other site
293826010967	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
293826010968	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
293826010969	Substrate-binding site [chemical binding]; other site
293826010970	Substrate specificity [chemical binding]; other site
293826010971	transposase/IS protein; Provisional; Region: PRK09183
293826010972	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826010973	Walker A motif; other site
293826010974	ATP binding site [chemical binding]; other site
293826010975	Walker B motif; other site
293826010976	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
293826010977	Integrase core domain; Region: rve; pfam00665
293826010978	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
293826010979	Accessory gene regulator B; Region: AgrB; pfam04647
293826010980	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826010981	ATP binding site [chemical binding]; other site
293826010982	Mg2+ binding site [ion binding]; other site
293826010983	G-X-G motif; other site
293826010984	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
293826010985	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826010986	active site
293826010987	phosphorylation site [posttranslational modification]
293826010988	intermolecular recognition site; other site
293826010989	dimerization interface [polypeptide binding]; other site
293826010990	LytTr DNA-binding domain; Region: LytTR; smart00850
293826010991	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
293826010992	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
293826010993	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
293826010994	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
293826010995	active site
293826010996	Ap6A binding site [chemical binding]; other site
293826010997	nudix motif; other site
293826010998	metal binding site [ion binding]; metal-binding site
293826010999	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
293826011000	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
293826011001	phosphate binding site [ion binding]; other site
293826011002	putative substrate binding pocket [chemical binding]; other site
293826011003	dimer interface [polypeptide binding]; other site
293826011004	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
293826011005	shikimate kinase; Provisional; Region: PRK13947
293826011006	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
293826011007	FAD binding domain; Region: FAD_binding_4; pfam01565
293826011008	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
293826011009	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
293826011010	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
293826011011	MOSC domain; Region: MOSC; pfam03473
293826011012	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
293826011013	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826011014	FeS/SAM binding site; other site
293826011015	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
293826011016	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
293826011017	Uncharacterized conserved protein [Function unknown]; Region: COG1633
293826011018	diiron binding motif [ion binding]; other site
293826011019	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
293826011020	molybdopterin cofactor binding site; other site
293826011021	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
293826011022	molybdopterin cofactor binding site; other site
293826011023	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
293826011024	catalytic loop [active]
293826011025	iron binding site [ion binding]; other site
293826011026	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
293826011027	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
293826011028	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
293826011029	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
293826011030	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
293826011031	dimer interface [polypeptide binding]; other site
293826011032	[2Fe-2S] cluster binding site [ion binding]; other site
293826011033	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
293826011034	SLBB domain; Region: SLBB; pfam10531
293826011035	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
293826011036	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
293826011037	4Fe-4S binding domain; Region: Fer4; pfam00037
293826011038	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
293826011039	dimer interface [polypeptide binding]; other site
293826011040	[2Fe-2S] cluster binding site [ion binding]; other site
293826011041	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
293826011042	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
293826011043	putative dimer interface [polypeptide binding]; other site
293826011044	[2Fe-2S] cluster binding site [ion binding]; other site
293826011045	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
293826011046	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
293826011047	G1 box; other site
293826011048	GTP/Mg2+ binding site [chemical binding]; other site
293826011049	Switch I region; other site
293826011050	G2 box; other site
293826011051	Switch II region; other site
293826011052	G3 box; other site
293826011053	G4 box; other site
293826011054	G5 box; other site
293826011055	Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666
293826011056	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
293826011057	biotin synthase; Provisional; Region: PRK07094
293826011058	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826011059	FeS/SAM binding site; other site
293826011060	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
293826011061	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
293826011062	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826011063	FeS/SAM binding site; other site
293826011064	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
293826011065	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
293826011066	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
293826011067	catalytic loop [active]
293826011068	iron binding site [ion binding]; other site
293826011069	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
293826011070	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
293826011071	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
293826011072	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
293826011073	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
293826011074	dimer interface [polypeptide binding]; other site
293826011075	[2Fe-2S] cluster binding site [ion binding]; other site
293826011076	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
293826011077	SLBB domain; Region: SLBB; pfam10531
293826011078	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
293826011079	4Fe-4S binding domain; Region: Fer4; pfam00037
293826011080	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
293826011081	4Fe-4S binding domain; Region: Fer4; pfam00037
293826011082	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
293826011083	dimer interface [polypeptide binding]; other site
293826011084	[2Fe-2S] cluster binding site [ion binding]; other site
293826011085	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
293826011086	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
293826011087	putative dimer interface [polypeptide binding]; other site
293826011088	[2Fe-2S] cluster binding site [ion binding]; other site
293826011089	GAF domain; Region: GAF; pfam01590
293826011090	GAF domain; Region: GAF_2; pfam13185
293826011091	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
293826011092	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826011093	Walker A motif; other site
293826011094	ATP binding site [chemical binding]; other site
293826011095	Walker B motif; other site
293826011096	arginine finger; other site
293826011097	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
293826011098	DNA-binding interface [nucleotide binding]; DNA binding site
293826011099	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
293826011100	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
293826011101	dimer interface [polypeptide binding]; other site
293826011102	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826011103	catalytic residue [active]
293826011104	DAK2 domain; Region: Dak2; pfam02734
293826011105	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
293826011106	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
293826011107	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
293826011108	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
293826011109	Walker A/P-loop; other site
293826011110	ATP binding site [chemical binding]; other site
293826011111	Q-loop/lid; other site
293826011112	ABC transporter signature motif; other site
293826011113	Walker B; other site
293826011114	D-loop; other site
293826011115	H-loop/switch region; other site
293826011116	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
293826011117	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
293826011118	Walker A/P-loop; other site
293826011119	ATP binding site [chemical binding]; other site
293826011120	Q-loop/lid; other site
293826011121	ABC transporter signature motif; other site
293826011122	Walker B; other site
293826011123	D-loop; other site
293826011124	H-loop/switch region; other site
293826011125	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
293826011126	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
293826011127	TM-ABC transporter signature motif; other site
293826011128	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
293826011129	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
293826011130	TM-ABC transporter signature motif; other site
293826011131	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
293826011132	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems; Region: PBP1_ABC_ligand_binding_like_14; cd06349
293826011133	putative ligand binding site [chemical binding]; other site
293826011134	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
293826011135	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
293826011136	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
293826011137	nucleotide binding site [chemical binding]; other site
293826011138	Anticodon-binding domain; Region: AD; cl10767
293826011139	HPr kinase/phosphorylase; Provisional; Region: PRK05428
293826011140	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
293826011141	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
293826011142	Hpr binding site; other site
293826011143	active site
293826011144	homohexamer subunit interaction site [polypeptide binding]; other site
293826011145	PspC domain; Region: PspC; pfam04024
293826011146	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
293826011147	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
293826011148	GIY-YIG motif/motif A; other site
293826011149	active site
293826011150	catalytic site [active]
293826011151	putative DNA binding site [nucleotide binding]; other site
293826011152	metal binding site [ion binding]; metal-binding site
293826011153	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
293826011154	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
293826011155	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
293826011156	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
293826011157	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826011158	ABC transporter signature motif; other site
293826011159	Walker B; other site
293826011160	D-loop; other site
293826011161	H-loop/switch region; other site
293826011162	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
293826011163	excinuclease ABC subunit B; Provisional; Region: PRK05298
293826011164	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
293826011165	ATP binding site [chemical binding]; other site
293826011166	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
293826011167	nucleotide binding region [chemical binding]; other site
293826011168	ATP-binding site [chemical binding]; other site
293826011169	Ultra-violet resistance protein B; Region: UvrB; pfam12344
293826011170	UvrB/uvrC motif; Region: UVR; pfam02151
293826011171	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
293826011172	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
293826011173	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
293826011174	protein binding site [polypeptide binding]; other site
293826011175	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
293826011176	Catalytic dyad [active]
293826011177	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
293826011178	Peptidase family M23; Region: Peptidase_M23; pfam01551
293826011179	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
293826011180	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
293826011181	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
293826011182	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826011183	Walker A/P-loop; other site
293826011184	ATP binding site [chemical binding]; other site
293826011185	Q-loop/lid; other site
293826011186	ABC transporter signature motif; other site
293826011187	Walker B; other site
293826011188	D-loop; other site
293826011189	H-loop/switch region; other site
293826011190	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
293826011191	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
293826011192	AAA domain; Region: AAA_32; pfam13654
293826011193	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
293826011194	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826011195	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
293826011196	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826011197	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
293826011198	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826011199	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
293826011200	PrcB C-terminal; Region: PrcB_C; pfam14343
293826011201	Uncharacterized conserved protein [Function unknown]; Region: COG1284
293826011202	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
293826011203	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
293826011204	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
293826011205	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
293826011206	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
293826011207	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
293826011208	PemK-like protein; Region: PemK; pfam02452
293826011209	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
293826011210	alanine racemase; Reviewed; Region: alr; PRK00053
293826011211	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
293826011212	active site
293826011213	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
293826011214	dimer interface [polypeptide binding]; other site
293826011215	substrate binding site [chemical binding]; other site
293826011216	catalytic residues [active]
293826011217	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
293826011218	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
293826011219	Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651
293826011220	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
293826011221	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
293826011222	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
293826011223	NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00200
293826011224	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
293826011225	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
293826011226	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
293826011227	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
293826011228	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
293826011229	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
293826011230	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
293826011231	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
293826011232	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
293826011233	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826011234	Walker A/P-loop; other site
293826011235	ATP binding site [chemical binding]; other site
293826011236	Q-loop/lid; other site
293826011237	ABC transporter signature motif; other site
293826011238	Walker B; other site
293826011239	D-loop; other site
293826011240	H-loop/switch region; other site
293826011241	FOG: CBS domain [General function prediction only]; Region: COG0517
293826011242	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636
293826011243	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
293826011244	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826011245	Walker A/P-loop; other site
293826011246	ATP binding site [chemical binding]; other site
293826011247	Q-loop/lid; other site
293826011248	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
293826011249	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826011250	ABC transporter signature motif; other site
293826011251	Walker B; other site
293826011252	D-loop; other site
293826011253	H-loop/switch region; other site
293826011254	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
293826011255	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
293826011256	active site
293826011257	metal binding site [ion binding]; metal-binding site
293826011258	DNA binding site [nucleotide binding]
293826011259	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
293826011260	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
293826011261	Part of AAA domain; Region: AAA_19; pfam13245
293826011262	Family description; Region: UvrD_C_2; pfam13538
293826011263	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
293826011264	S-layer homology domain; Region: SLH; pfam00395
293826011265	S-layer homology domain; Region: SLH; pfam00395
293826011266	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
293826011267	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
293826011268	Walker A/P-loop; other site
293826011269	ATP binding site [chemical binding]; other site
293826011270	Q-loop/lid; other site
293826011271	ABC transporter signature motif; other site
293826011272	Walker B; other site
293826011273	D-loop; other site
293826011274	H-loop/switch region; other site
293826011275	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
293826011276	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
293826011277	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
293826011278	HD domain; Region: HD_5; pfam13487
293826011279	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
293826011280	generic binding surface I; other site
293826011281	generic binding surface II; other site
293826011282	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826011283	Zn2+ binding site [ion binding]; other site
293826011284	Mg2+ binding site [ion binding]; other site
293826011285	Rubrerythrin [Energy production and conversion]; Region: COG1592
293826011286	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
293826011287	binuclear metal center [ion binding]; other site
293826011288	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350
293826011289	iron binding site [ion binding]; other site
293826011290	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
293826011291	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
293826011292	active site
293826011293	dimer interface [polypeptide binding]; other site
293826011294	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
293826011295	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
293826011296	active site
293826011297	trimer interface [polypeptide binding]; other site
293826011298	allosteric site; other site
293826011299	active site lid [active]
293826011300	hexamer (dimer of trimers) interface [polypeptide binding]; other site
293826011301	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
293826011302	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
293826011303	putative active site [active]
293826011304	YdjC motif; other site
293826011305	Mg binding site [ion binding]; other site
293826011306	putative homodimer interface [polypeptide binding]; other site
293826011307	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
293826011308	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
293826011309	NAD binding site [chemical binding]; other site
293826011310	sugar binding site [chemical binding]; other site
293826011311	divalent metal binding site [ion binding]; other site
293826011312	tetramer (dimer of dimers) interface [polypeptide binding]; other site
293826011313	dimer interface [polypeptide binding]; other site
293826011314	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
293826011315	active site
293826011316	methionine cluster; other site
293826011317	phosphorylation site [posttranslational modification]
293826011318	metal binding site [ion binding]; metal-binding site
293826011319	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
293826011320	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
293826011321	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
293826011322	active site
293826011323	P-loop; other site
293826011324	phosphorylation site [posttranslational modification]
293826011325	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
293826011326	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
293826011327	putative active site [active]
293826011328	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
293826011329	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
293826011330	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
293826011331	putative active site [active]
293826011332	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
293826011333	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
293826011334	methionine cluster; other site
293826011335	active site
293826011336	phosphorylation site [posttranslational modification]
293826011337	metal binding site [ion binding]; metal-binding site
293826011338	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
293826011339	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
293826011340	NAD binding site [chemical binding]; other site
293826011341	sugar binding site [chemical binding]; other site
293826011342	divalent metal binding site [ion binding]; other site
293826011343	tetramer (dimer of dimers) interface [polypeptide binding]; other site
293826011344	dimer interface [polypeptide binding]; other site
293826011345	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
293826011346	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
293826011347	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
293826011348	active site
293826011349	P-loop; other site
293826011350	phosphorylation site [posttranslational modification]
293826011351	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
293826011352	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826011353	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
293826011354	Walker A motif; other site
293826011355	ATP binding site [chemical binding]; other site
293826011356	Walker B motif; other site
293826011357	arginine finger; other site
293826011358	Transcriptional antiterminator [Transcription]; Region: COG3933
293826011359	PRD domain; Region: PRD; pfam00874
293826011360	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
293826011361	active pocket/dimerization site; other site
293826011362	active site
293826011363	phosphorylation site [posttranslational modification]
293826011364	PRD domain; Region: PRD; pfam00874
293826011365	phosphatidylserine decarboxylase; Provisional; Region: PRK00723
293826011366	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
293826011367	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
293826011368	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
293826011369	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
293826011370	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
293826011371	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
293826011372	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
293826011373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826011374	active site
293826011375	phosphorylation site [posttranslational modification]
293826011376	intermolecular recognition site; other site
293826011377	dimerization interface [polypeptide binding]; other site
293826011378	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
293826011379	DNA binding residues [nucleotide binding]
293826011380	dimerization interface [polypeptide binding]; other site
293826011381	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
293826011382	Histidine kinase; Region: HisKA_3; pfam07730
293826011383	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
293826011384	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
293826011385	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
293826011386	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
293826011387	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
293826011388	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
293826011389	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826011390	Walker A/P-loop; other site
293826011391	ATP binding site [chemical binding]; other site
293826011392	Q-loop/lid; other site
293826011393	ABC transporter signature motif; other site
293826011394	Walker B; other site
293826011395	D-loop; other site
293826011396	H-loop/switch region; other site
293826011397	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
293826011398	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
293826011399	active site
293826011400	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
293826011401	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
293826011402	heterodimer interface [polypeptide binding]; other site
293826011403	active site
293826011404	FMN binding site [chemical binding]; other site
293826011405	homodimer interface [polypeptide binding]; other site
293826011406	substrate binding site [chemical binding]; other site
293826011407	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
293826011408	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
293826011409	FAD binding pocket [chemical binding]; other site
293826011410	FAD binding motif [chemical binding]; other site
293826011411	phosphate binding motif [ion binding]; other site
293826011412	beta-alpha-beta structure motif; other site
293826011413	NAD binding pocket [chemical binding]; other site
293826011414	Iron coordination center [ion binding]; other site
293826011415	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
293826011416	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
293826011417	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
293826011418	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
293826011419	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
293826011420	ATP-grasp domain; Region: ATP-grasp_4; cl17255
293826011421	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
293826011422	IMP binding site; other site
293826011423	dimer interface [polypeptide binding]; other site
293826011424	interdomain contacts; other site
293826011425	partial ornithine binding site; other site
293826011426	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
293826011427	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
293826011428	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
293826011429	catalytic site [active]
293826011430	subunit interface [polypeptide binding]; other site
293826011431	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
293826011432	active site
293826011433	dimer interface [polypeptide binding]; other site
293826011434	dihydroorotase; Validated; Region: pyrC; PRK09357
293826011435	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
293826011436	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
293826011437	active site
293826011438	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769
293826011439	SxDxEG motif; other site
293826011440	putative active site [active]
293826011441	putative metal binding site [ion binding]; other site
293826011442	DNA polymerase IV; Provisional; Region: PRK14133
293826011443	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
293826011444	active site
293826011445	DNA binding site [nucleotide binding]
293826011446	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
293826011447	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
293826011448	putative dimer interface [polypeptide binding]; other site
293826011449	putative anticodon binding site; other site
293826011450	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
293826011451	homodimer interface [polypeptide binding]; other site
293826011452	motif 1; other site
293826011453	motif 2; other site
293826011454	active site
293826011455	motif 3; other site
293826011456	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
293826011457	H+ Antiporter protein; Region: 2A0121; TIGR00900
293826011458	putative substrate translocation pore; other site
293826011459	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
293826011460	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777
293826011461	DNA binding residues [nucleotide binding]
293826011462	putative dimer interface [polypeptide binding]; other site
293826011463	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826011464	S-adenosylmethionine binding site [chemical binding]; other site
293826011465	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
293826011466	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
293826011467	DEAD_2; Region: DEAD_2; pfam06733
293826011468	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
293826011469	SpoVA protein; Region: SpoVA; cl04298
293826011470	stage V sporulation protein AD; Provisional; Region: PRK12404
293826011471	Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451
293826011472	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
293826011473	Predicted membrane protein [Function unknown]; Region: COG2323
293826011474	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
293826011475	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
293826011476	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
293826011477	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
293826011478	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
293826011479	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
293826011480	NAD binding site [chemical binding]; other site
293826011481	ligand binding site [chemical binding]; other site
293826011482	catalytic site [active]
293826011483	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
293826011484	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
293826011485	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
293826011486	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
293826011487	thiamine phosphate binding site [chemical binding]; other site
293826011488	active site
293826011489	pyrophosphate binding site [ion binding]; other site
293826011490	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
293826011491	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
293826011492	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
293826011493	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826011494	FeS/SAM binding site; other site
293826011495	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
293826011496	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
293826011497	ThiS interaction site; other site
293826011498	putative active site [active]
293826011499	tetramer interface [polypeptide binding]; other site
293826011500	ThiS-like ubiquitin; Region: ThiS-like; pfam14453
293826011501	thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644
293826011502	E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487
293826011503	putative ATP binding site [chemical binding]; other site
293826011504	putative substrate interface [chemical binding]; other site
293826011505	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
293826011506	thiS-thiF/thiG interaction site; other site
293826011507	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
293826011508	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
293826011509	Citrate transporter; Region: CitMHS; pfam03600
293826011510	PAS domain S-box; Region: sensory_box; TIGR00229
293826011511	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826011512	putative active site [active]
293826011513	heme pocket [chemical binding]; other site
293826011514	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
293826011515	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826011516	Walker A motif; other site
293826011517	ATP binding site [chemical binding]; other site
293826011518	Walker B motif; other site
293826011519	arginine finger; other site
293826011520	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
293826011521	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
293826011522	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
293826011523	PAS domain; Region: PAS; smart00091
293826011524	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
293826011525	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826011526	Walker A motif; other site
293826011527	ATP binding site [chemical binding]; other site
293826011528	Walker B motif; other site
293826011529	arginine finger; other site
293826011530	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
293826011531	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
293826011532	RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3
293826011533	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826011534	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826011535	DNA binding residues [nucleotide binding]
293826011536	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826011537	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
293826011538	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826011539	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
293826011540	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
293826011541	NodB motif; other site
293826011542	active site
293826011543	catalytic site [active]
293826011544	metal binding site [ion binding]; metal-binding site
293826011545	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
293826011546	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
293826011547	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
293826011548	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
293826011549	active site
293826011550	HIGH motif; other site
293826011551	nucleotide binding site [chemical binding]; other site
293826011552	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
293826011553	KMSKS motif; other site
293826011554	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
293826011555	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
293826011556	ligand binding site [chemical binding]; other site
293826011557	active site
293826011558	UGI interface [polypeptide binding]; other site
293826011559	catalytic site [active]
293826011560	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
293826011561	putative efflux protein, MATE family; Region: matE; TIGR00797
293826011562	Protein of unknown function DUF45; Region: DUF45; pfam01863
293826011563	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
293826011564	aspartate racemase; Region: asp_race; TIGR00035
293826011565	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
293826011566	diiron binding motif [ion binding]; other site
293826011567	Haemolysin-III related; Region: HlyIII; cl03831
293826011568	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
293826011569	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
293826011570	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
293826011571	active site
293826011572	YCII-related domain; Region: YCII; cl00999
293826011573	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
293826011574	ZIP Zinc transporter; Region: Zip; pfam02535
293826011575	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
293826011576	aromatic arch; other site
293826011577	DCoH dimer interaction site [polypeptide binding]; other site
293826011578	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
293826011579	DCoH tetramer interaction site [polypeptide binding]; other site
293826011580	substrate binding site [chemical binding]; other site
293826011581	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
293826011582	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
293826011583	putative NAD(P) binding site [chemical binding]; other site
293826011584	catalytic Zn binding site [ion binding]; other site
293826011585	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
293826011586	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
293826011587	putative substrate binding site [chemical binding]; other site
293826011588	putative ATP binding site [chemical binding]; other site
293826011589	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
293826011590	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
293826011591	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
293826011592	active site
293826011593	P-loop; other site
293826011594	phosphorylation site [posttranslational modification]
293826011595	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
293826011596	active site
293826011597	phosphorylation site [posttranslational modification]
293826011598	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
293826011599	HTH domain; Region: HTH_11; pfam08279
293826011600	PRD domain; Region: PRD; pfam00874
293826011601	PRD domain; Region: PRD; pfam00874
293826011602	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
293826011603	active site
293826011604	P-loop; other site
293826011605	phosphorylation site [posttranslational modification]
293826011606	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
293826011607	active site
293826011608	phosphorylation site [posttranslational modification]
293826011609	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
293826011610	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
293826011611	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
293826011612	active site
293826011613	P-loop; other site
293826011614	phosphorylation site [posttranslational modification]
293826011615	Coat F domain; Region: Coat_F; pfam07875
293826011616	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
293826011617	tartrate dehydrogenase; Provisional; Region: PRK08194
293826011618	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
293826011619	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
293826011620	ligand binding site [chemical binding]; other site
293826011621	NAD binding site [chemical binding]; other site
293826011622	dimerization interface [polypeptide binding]; other site
293826011623	catalytic site [active]
293826011624	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
293826011625	putative L-serine binding site [chemical binding]; other site
293826011626	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
293826011627	nudix motif; other site
293826011628	CAAX protease self-immunity; Region: Abi; pfam02517
293826011629	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
293826011630	catalytic site [active]
293826011631	metal binding site [ion binding]; metal-binding site
293826011632	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826011633	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
293826011634	Coenzyme A binding pocket [chemical binding]; other site
293826011635	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
293826011636	active site
293826011637	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
293826011638	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
293826011639	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
293826011640	Zn2+ binding site [ion binding]; other site
293826011641	Mg2+ binding site [ion binding]; other site
293826011642	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
293826011643	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
293826011644	putative active site [active]
293826011645	putative NTP binding site [chemical binding]; other site
293826011646	putative nucleic acid binding site [nucleotide binding]; other site
293826011647	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
293826011648	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
293826011649	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
293826011650	catalytic residues [active]
293826011651	catalytic nucleophile [active]
293826011652	Recombinase; Region: Recombinase; pfam07508
293826011653	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
293826011654	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
293826011655	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
293826011656	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
293826011657	Methyltransferase domain; Region: Methyltransf_31; pfam13847
293826011658	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826011659	S-adenosylmethionine binding site [chemical binding]; other site
293826011660	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
293826011661	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
293826011662	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
293826011663	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
293826011664	glutaminase active site [active]
293826011665	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
293826011666	dimer interface [polypeptide binding]; other site
293826011667	active site
293826011668	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
293826011669	dimer interface [polypeptide binding]; other site
293826011670	active site
293826011671	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
293826011672	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
293826011673	active site
293826011674	substrate binding site [chemical binding]; other site
293826011675	metal binding site [ion binding]; metal-binding site
293826011676	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
293826011677	Carbon starvation protein CstA; Region: CstA; pfam02554
293826011678	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
293826011679	MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar...; Region: MIT; cl00299
293826011680	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
293826011681	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
293826011682	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
293826011683	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
293826011684	TPP-binding site [chemical binding]; other site
293826011685	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
293826011686	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
293826011687	dimer interface [polypeptide binding]; other site
293826011688	PYR/PP interface [polypeptide binding]; other site
293826011689	TPP binding site [chemical binding]; other site
293826011690	substrate binding site [chemical binding]; other site
293826011691	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
293826011692	Ferredoxin [Energy production and conversion]; Region: COG1146
293826011693	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
293826011694	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
293826011695	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
293826011696	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
293826011697	nucleotide binding site [chemical binding]; other site
293826011698	Acetokinase family; Region: Acetate_kinase; cl17229
293826011699	phosphate butyryltransferase; Validated; Region: PRK05805
293826011700	butyrate kinase; Provisional; Region: PRK03011
293826011701	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
293826011702	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826011703	putative active site [active]
293826011704	heme pocket [chemical binding]; other site
293826011705	PAS domain; Region: PAS; smart00091
293826011706	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826011707	Walker A motif; other site
293826011708	ATP binding site [chemical binding]; other site
293826011709	Walker B motif; other site
293826011710	arginine finger; other site
293826011711	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
293826011712	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
293826011713	YbbR-like protein; Region: YbbR; pfam07949
293826011714	YbbR-like protein; Region: YbbR; pfam07949
293826011715	Uncharacterized conserved protein [Function unknown]; Region: COG1624
293826011716	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
293826011717	BON domain; Region: BON; pfam04972
293826011718	BON domain; Region: BON; pfam04972
293826011719	BON domain; Region: BON; pfam04972
293826011720	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
293826011721	NAD(P) binding pocket [chemical binding]; other site
293826011722	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
293826011723	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
293826011724	inhibitor-cofactor binding pocket; inhibition site
293826011725	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826011726	catalytic residue [active]
293826011727	Ion channel; Region: Ion_trans_2; pfam07885
293826011728	Protein of unknown function (DUF1576); Region: DUF1576; pfam07613
293826011729	Protein of unknown function (DUF1576); Region: DUF1576; pfam07613
293826011730	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
293826011731	Domain of unknown function DUF; Region: DUF204; pfam02659
293826011732	Protein of unknown function (DUF1622); Region: DUF1622; cl01991
293826011733	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826011734	dimer interface [polypeptide binding]; other site
293826011735	phosphorylation site [posttranslational modification]
293826011736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826011737	ATP binding site [chemical binding]; other site
293826011738	Mg2+ binding site [ion binding]; other site
293826011739	G-X-G motif; other site
293826011740	hypothetical protein; Provisional; Region: PRK09609
293826011741	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
293826011742	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
293826011743	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
293826011744	catalytic residues [active]
293826011745	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
293826011746	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
293826011747	minor groove reading motif; other site
293826011748	helix-hairpin-helix signature motif; other site
293826011749	substrate binding pocket [chemical binding]; other site
293826011750	active site
293826011751	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
293826011752	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
293826011753	DNA binding and oxoG recognition site [nucleotide binding]
293826011754	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
293826011755	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
293826011756	dimer interface [polypeptide binding]; other site
293826011757	decamer (pentamer of dimers) interface [polypeptide binding]; other site
293826011758	catalytic triad [active]
293826011759	peroxidatic and resolving cysteines [active]
293826011760	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
293826011761	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
293826011762	GSH binding site [chemical binding]; other site
293826011763	catalytic residues [active]
293826011764	N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846
293826011765	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
293826011766	Domain of unknown function (DUF4363); Region: DUF4363; pfam14276
293826011767	Predicted membrane protein [Function unknown]; Region: COG2323
293826011768	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
293826011769	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
293826011770	active site
293826011771	FMN binding site [chemical binding]; other site
293826011772	substrate binding site [chemical binding]; other site
293826011773	homotetramer interface [polypeptide binding]; other site
293826011774	catalytic residue [active]
293826011775	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
293826011776	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
293826011777	metal binding site [ion binding]; metal-binding site
293826011778	dimer interface [polypeptide binding]; other site
293826011779	diaminopimelate decarboxylase; Region: lysA; TIGR01048
293826011780	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
293826011781	active site
293826011782	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
293826011783	substrate binding site [chemical binding]; other site
293826011784	catalytic residues [active]
293826011785	dimer interface [polypeptide binding]; other site
293826011786	succinic semialdehyde dehydrogenase; Region: PLN02278
293826011787	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
293826011788	tetramerization interface [polypeptide binding]; other site
293826011789	NAD(P) binding site [chemical binding]; other site
293826011790	catalytic residues [active]
293826011791	Bacitracin resistance protein BacA; Region: BacA; pfam02673
293826011792	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
293826011793	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
293826011794	active site
293826011795	DNA binding site [nucleotide binding]
293826011796	Int/Topo IB signature motif; other site
293826011797	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900
293826011798	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
293826011799	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
293826011800	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
293826011801	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
293826011802	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
293826011803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834
293826011804	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
293826011805	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566
293826011806	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
293826011807	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
293826011808	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
293826011809	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
293826011810	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
293826011811	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
293826011812	transcription termination/antitermination factor NusG; Region: nusG; TIGR00922
293826011813	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000
293826011814	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
293826011815	heterodimer interface [polypeptide binding]; other site
293826011816	homodimer interface [polypeptide binding]; other site
293826011817	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
293826011818	Mor transcription activator family; Region: Mor; cl02360
293826011819	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
293826011820	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
293826011821	active site
293826011822	Bacterial SH3 domain; Region: SH3_3; cl17532
293826011823	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
293826011824	3D domain; Region: 3D; cl01439
293826011825	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
293826011826	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
293826011827	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826011828	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826011829	DNA binding residues [nucleotide binding]
293826011830	Protein of unknown function (DUF1018); Region: DUF1018; cl01815
293826011831	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
293826011832	AAA domain; Region: AAA_22; pfam13401
293826011833	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
293826011834	non-specific DNA binding site [nucleotide binding]; other site
293826011835	salt bridge; other site
293826011836	sequence-specific DNA binding site [nucleotide binding]; other site
293826011837	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
293826011838	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826011839	non-specific DNA binding site [nucleotide binding]; other site
293826011840	salt bridge; other site
293826011841	sequence-specific DNA binding site [nucleotide binding]; other site
293826011842	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
293826011843	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
293826011844	non-specific DNA binding site [nucleotide binding]; other site
293826011845	salt bridge; other site
293826011846	sequence-specific DNA binding site [nucleotide binding]; other site
293826011847	Transposase [DNA replication, recombination, and repair]; Region: COG5421
293826011848	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
293826011849	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
293826011850	Hemerythrin-like domain; Region: Hr-like; cd12108
293826011851	Fe binding site [ion binding]; other site
293826011852	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
293826011853	homodimer interface [polypeptide binding]; other site
293826011854	metal binding site [ion binding]; metal-binding site
293826011855	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
293826011856	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
293826011857	active site
293826011858	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
293826011859	dimer interface [polypeptide binding]; other site
293826011860	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
293826011861	Ligand Binding Site [chemical binding]; other site
293826011862	Molecular Tunnel; other site
293826011863	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
293826011864	Domain of unknown function DUF21; Region: DUF21; pfam01595
293826011865	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
293826011866	Transporter associated domain; Region: CorC_HlyC; smart01091
293826011867	PAS domain S-box; Region: sensory_box; TIGR00229
293826011868	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826011869	putative active site [active]
293826011870	heme pocket [chemical binding]; other site
293826011871	PAS domain S-box; Region: sensory_box; TIGR00229
293826011872	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826011873	putative active site [active]
293826011874	heme pocket [chemical binding]; other site
293826011875	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
293826011876	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826011877	putative active site [active]
293826011878	heme pocket [chemical binding]; other site
293826011879	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826011880	dimer interface [polypeptide binding]; other site
293826011881	phosphorylation site [posttranslational modification]
293826011882	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826011883	ATP binding site [chemical binding]; other site
293826011884	Mg2+ binding site [ion binding]; other site
293826011885	G-X-G motif; other site
293826011886	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
293826011887	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
293826011888	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
293826011889	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826011890	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826011891	dimer interface [polypeptide binding]; other site
293826011892	phosphorylation site [posttranslational modification]
293826011893	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826011894	ATP binding site [chemical binding]; other site
293826011895	Mg2+ binding site [ion binding]; other site
293826011896	G-X-G motif; other site
293826011897	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
293826011898	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
293826011899	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
293826011900	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
293826011901	TrkA-N domain; Region: TrkA_N; pfam02254
293826011902	TrkA-C domain; Region: TrkA_C; pfam02080
293826011903	TrkA-N domain; Region: TrkA_N; pfam02254
293826011904	TrkA-C domain; Region: TrkA_C; pfam02080
293826011905	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
293826011906	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
293826011907	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
293826011908	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
293826011909	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
293826011910	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
293826011911	metal binding site [ion binding]; metal-binding site
293826011912	active site
293826011913	I-site; other site
293826011914	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
293826011915	Uncharacterized conserved protein [Function unknown]; Region: COG3461
293826011916	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
293826011917	Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782
293826011918	DNA binding residues [nucleotide binding]
293826011919	dimer interface [polypeptide binding]; other site
293826011920	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
293826011921	Arginase family; Region: Arginase; cd09989
293826011922	active site
293826011923	Mn binding site [ion binding]; other site
293826011924	oligomer interface [polypeptide binding]; other site
293826011925	lipoyl synthase; Provisional; Region: PRK05481
293826011926	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
293826011927	FeS/SAM binding site; other site
293826011928	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
293826011929	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
293826011930	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
293826011931	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
293826011932	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
293826011933	TPP-binding site [chemical binding]; other site
293826011934	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
293826011935	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
293826011936	dimer interface [polypeptide binding]; other site
293826011937	PYR/PP interface [polypeptide binding]; other site
293826011938	TPP binding site [chemical binding]; other site
293826011939	substrate binding site [chemical binding]; other site
293826011940	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
293826011941	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
293826011942	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
293826011943	butyrate kinase; Provisional; Region: PRK03011
293826011944	Transcriptional regulator [Transcription]; Region: LysR; COG0583
293826011945	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
293826011946	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
293826011947	dimerization interface [polypeptide binding]; other site
293826011948	substrate binding pocket [chemical binding]; other site
293826011949	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826011950	PAS domain; Region: PAS_9; pfam13426
293826011951	putative active site [active]
293826011952	heme pocket [chemical binding]; other site
293826011953	PAS domain S-box; Region: sensory_box; TIGR00229
293826011954	PAS domain; Region: PAS; smart00091
293826011955	putative active site [active]
293826011956	PAS domain S-box; Region: sensory_box; TIGR00229
293826011957	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826011958	putative active site [active]
293826011959	heme pocket [chemical binding]; other site
293826011960	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
293826011961	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826011962	putative active site [active]
293826011963	heme pocket [chemical binding]; other site
293826011964	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826011965	dimer interface [polypeptide binding]; other site
293826011966	phosphorylation site [posttranslational modification]
293826011967	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826011968	ATP binding site [chemical binding]; other site
293826011969	Mg2+ binding site [ion binding]; other site
293826011970	G-X-G motif; other site
293826011971	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
293826011972	QueT transporter; Region: QueT; pfam06177
293826011973	Rubrerythrin [Energy production and conversion]; Region: COG1592
293826011974	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
293826011975	binuclear metal center [ion binding]; other site
293826011976	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
293826011977	iron binding site [ion binding]; other site
293826011978	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
293826011979	NodB motif; other site
293826011980	putative active site [active]
293826011981	putative catalytic site [active]
293826011982	Zn binding site [ion binding]; other site
293826011983	Membrane protein of unknown function; Region: DUF360; pfam04020
293826011984	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
293826011985	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
293826011986	active site
293826011987	metal binding site [ion binding]; metal-binding site
293826011988	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
293826011989	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
293826011990	23S rRNA interface [nucleotide binding]; other site
293826011991	L3 interface [polypeptide binding]; other site
293826011992	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
293826011993	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
293826011994	dimerization interface 3.5A [polypeptide binding]; other site
293826011995	active site
293826011996	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
293826011997	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
293826011998	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
293826011999	Walker A/P-loop; other site
293826012000	ATP binding site [chemical binding]; other site
293826012001	Q-loop/lid; other site
293826012002	ABC transporter signature motif; other site
293826012003	Walker B; other site
293826012004	D-loop; other site
293826012005	H-loop/switch region; other site
293826012006	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
293826012007	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
293826012008	Walker A/P-loop; other site
293826012009	ATP binding site [chemical binding]; other site
293826012010	Q-loop/lid; other site
293826012011	ABC transporter signature motif; other site
293826012012	Walker B; other site
293826012013	D-loop; other site
293826012014	H-loop/switch region; other site
293826012015	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
293826012016	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
293826012017	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
293826012018	alphaNTD homodimer interface [polypeptide binding]; other site
293826012019	alphaNTD - beta interaction site [polypeptide binding]; other site
293826012020	alphaNTD - beta' interaction site [polypeptide binding]; other site
293826012021	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
293826012022	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
293826012023	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
293826012024	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
293826012025	RNA binding surface [nucleotide binding]; other site
293826012026	30S ribosomal protein S11; Validated; Region: PRK05309
293826012027	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
293826012028	30S ribosomal protein S13; Region: bact_S13; TIGR03631
293826012029	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
293826012030	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
293826012031	rRNA binding site [nucleotide binding]; other site
293826012032	predicted 30S ribosome binding site; other site
293826012033	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
293826012034	RNA binding site [nucleotide binding]; other site
293826012035	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
293826012036	active site
293826012037	adenylate kinase; Reviewed; Region: adk; PRK00279
293826012038	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
293826012039	AMP-binding site [chemical binding]; other site
293826012040	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
293826012041	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
293826012042	SecY translocase; Region: SecY; pfam00344
293826012043	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
293826012044	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
293826012045	23S rRNA binding site [nucleotide binding]; other site
293826012046	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
293826012047	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
293826012048	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
293826012049	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
293826012050	5S rRNA interface [nucleotide binding]; other site
293826012051	L27 interface [polypeptide binding]; other site
293826012052	23S rRNA interface [nucleotide binding]; other site
293826012053	L5 interface [polypeptide binding]; other site
293826012054	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
293826012055	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
293826012056	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
293826012057	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
293826012058	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
293826012059	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
293826012060	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
293826012061	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
293826012062	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
293826012063	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
293826012064	RNA binding site [nucleotide binding]; other site
293826012065	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
293826012066	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
293826012067	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
293826012068	23S rRNA interface [nucleotide binding]; other site
293826012069	putative translocon interaction site; other site
293826012070	signal recognition particle (SRP54) interaction site; other site
293826012071	L23 interface [polypeptide binding]; other site
293826012072	trigger factor interaction site; other site
293826012073	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
293826012074	23S rRNA interface [nucleotide binding]; other site
293826012075	5S rRNA interface [nucleotide binding]; other site
293826012076	putative antibiotic binding site [chemical binding]; other site
293826012077	L25 interface [polypeptide binding]; other site
293826012078	L27 interface [polypeptide binding]; other site
293826012079	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
293826012080	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
293826012081	G-X-X-G motif; other site
293826012082	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
293826012083	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
293826012084	putative translocon binding site; other site
293826012085	protein-rRNA interface [nucleotide binding]; other site
293826012086	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
293826012087	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
293826012088	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
293826012089	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
293826012090	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
293826012091	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
293826012092	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
293826012093	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
293826012094	elongation factor Tu; Reviewed; Region: PRK00049
293826012095	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
293826012096	G1 box; other site
293826012097	GEF interaction site [polypeptide binding]; other site
293826012098	GTP/Mg2+ binding site [chemical binding]; other site
293826012099	Switch I region; other site
293826012100	G2 box; other site
293826012101	G3 box; other site
293826012102	Switch II region; other site
293826012103	G4 box; other site
293826012104	G5 box; other site
293826012105	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
293826012106	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
293826012107	Antibiotic Binding Site [chemical binding]; other site
293826012108	elongation factor G; Reviewed; Region: PRK00007
293826012109	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
293826012110	G1 box; other site
293826012111	putative GEF interaction site [polypeptide binding]; other site
293826012112	GTP/Mg2+ binding site [chemical binding]; other site
293826012113	Switch I region; other site
293826012114	G2 box; other site
293826012115	G3 box; other site
293826012116	Switch II region; other site
293826012117	G4 box; other site
293826012118	G5 box; other site
293826012119	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
293826012120	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
293826012121	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
293826012122	30S ribosomal protein S7; Validated; Region: PRK05302
293826012123	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
293826012124	S17 interaction site [polypeptide binding]; other site
293826012125	S8 interaction site; other site
293826012126	16S rRNA interaction site [nucleotide binding]; other site
293826012127	streptomycin interaction site [chemical binding]; other site
293826012128	23S rRNA interaction site [nucleotide binding]; other site
293826012129	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
293826012130	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602
293826012131	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
293826012132	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
293826012133	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
293826012134	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
293826012135	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
293826012136	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
293826012137	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
293826012138	G-loop; other site
293826012139	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
293826012140	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
293826012141	DNA binding site [nucleotide binding]
293826012142	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
293826012143	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
293826012144	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
293826012145	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
293826012146	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
293826012147	RPB1 interaction site [polypeptide binding]; other site
293826012148	RPB10 interaction site [polypeptide binding]; other site
293826012149	RPB11 interaction site [polypeptide binding]; other site
293826012150	RPB3 interaction site [polypeptide binding]; other site
293826012151	RPB12 interaction site [polypeptide binding]; other site
293826012152	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
293826012153	core dimer interface [polypeptide binding]; other site
293826012154	peripheral dimer interface [polypeptide binding]; other site
293826012155	L10 interface [polypeptide binding]; other site
293826012156	L11 interface [polypeptide binding]; other site
293826012157	putative EF-Tu interaction site [polypeptide binding]; other site
293826012158	putative EF-G interaction site [polypeptide binding]; other site
293826012159	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
293826012160	23S rRNA interface [nucleotide binding]; other site
293826012161	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
293826012162	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
293826012163	mRNA/rRNA interface [nucleotide binding]; other site
293826012164	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
293826012165	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
293826012166	23S rRNA interface [nucleotide binding]; other site
293826012167	L7/L12 interface [polypeptide binding]; other site
293826012168	putative thiostrepton binding site; other site
293826012169	L25 interface [polypeptide binding]; other site
293826012170	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
293826012171	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
293826012172	putative homodimer interface [polypeptide binding]; other site
293826012173	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
293826012174	heterodimer interface [polypeptide binding]; other site
293826012175	homodimer interface [polypeptide binding]; other site
293826012176	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
293826012177	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
293826012178	elongation factor Tu; Reviewed; Region: PRK00049
293826012179	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
293826012180	G1 box; other site
293826012181	GEF interaction site [polypeptide binding]; other site
293826012182	GTP/Mg2+ binding site [chemical binding]; other site
293826012183	Switch I region; other site
293826012184	G2 box; other site
293826012185	G3 box; other site
293826012186	Switch II region; other site
293826012187	G4 box; other site
293826012188	G5 box; other site
293826012189	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
293826012190	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
293826012191	Antibiotic Binding Site [chemical binding]; other site
293826012192	RNA polymerase factor sigma-70; Validated; Region: PRK08295
293826012193	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826012194	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
293826012195	YacP-like NYN domain; Region: NYN_YacP; pfam05991
293826012196	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
293826012197	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
293826012198	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
293826012199	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
293826012200	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
293826012201	active site
293826012202	metal binding site [ion binding]; metal-binding site
293826012203	dimerization interface [polypeptide binding]; other site
293826012204	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
293826012205	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
293826012206	active site
293826012207	HIGH motif; other site
293826012208	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
293826012209	KMSKS motif; other site
293826012210	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
293826012211	tRNA binding surface [nucleotide binding]; other site
293826012212	anticodon binding site; other site
293826012213	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
293826012214	serine O-acetyltransferase; Region: cysE; TIGR01172
293826012215	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
293826012216	trimer interface [polypeptide binding]; other site
293826012217	active site
293826012218	substrate binding site [chemical binding]; other site
293826012219	CoA binding site [chemical binding]; other site
293826012220	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
293826012221	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
293826012222	HIGH motif; other site
293826012223	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
293826012224	active site
293826012225	KMSKS motif; other site
293826012226	Predicted secreted protein [Function unknown]; Region: COG4086
293826012227	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
293826012228	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
293826012229	homotrimer interaction site [polypeptide binding]; other site
293826012230	zinc binding site [ion binding]; other site
293826012231	CDP-binding sites; other site
293826012232	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
293826012233	substrate binding site; other site
293826012234	dimer interface; other site
293826012235	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
293826012236	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
293826012237	putative active site [active]
293826012238	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
293826012239	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
293826012240	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
293826012241	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
293826012242	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
293826012243	DNA repair protein RadA; Provisional; Region: PRK11823
293826012244	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
293826012245	Walker A motif/ATP binding site; other site
293826012246	ATP binding site [chemical binding]; other site
293826012247	Walker B motif; other site
293826012248	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
293826012249	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
293826012250	Clp amino terminal domain; Region: Clp_N; pfam02861
293826012251	Clp amino terminal domain; Region: Clp_N; pfam02861
293826012252	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826012253	Walker A motif; other site
293826012254	ATP binding site [chemical binding]; other site
293826012255	Walker B motif; other site
293826012256	arginine finger; other site
293826012257	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826012258	Walker A motif; other site
293826012259	ATP binding site [chemical binding]; other site
293826012260	Walker B motif; other site
293826012261	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
293826012262	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
293826012263	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
293826012264	ADP binding site [chemical binding]; other site
293826012265	phosphagen binding site; other site
293826012266	substrate specificity loop; other site
293826012267	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
293826012268	UvrB/uvrC motif; Region: UVR; pfam02151
293826012269	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
293826012270	elongation factor G; Reviewed; Region: PRK12740
293826012271	G1 box; other site
293826012272	putative GEF interaction site [polypeptide binding]; other site
293826012273	GTP/Mg2+ binding site [chemical binding]; other site
293826012274	Switch I region; other site
293826012275	G2 box; other site
293826012276	G3 box; other site
293826012277	Switch II region; other site
293826012278	G4 box; other site
293826012279	G5 box; other site
293826012280	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
293826012281	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
293826012282	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
293826012283	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
293826012284	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
293826012285	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826012286	homodimer interface [polypeptide binding]; other site
293826012287	catalytic residue [active]
293826012288	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
293826012289	E-class dimer interface [polypeptide binding]; other site
293826012290	P-class dimer interface [polypeptide binding]; other site
293826012291	active site
293826012292	Cu2+ binding site [ion binding]; other site
293826012293	Zn2+ binding site [ion binding]; other site
293826012294	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
293826012295	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
293826012296	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
293826012297	Cl- selectivity filter; other site
293826012298	Cl- binding residues [ion binding]; other site
293826012299	pore gating glutamate residue; other site
293826012300	dimer interface [polypeptide binding]; other site
293826012301	ATP cone domain; Region: ATP-cone; pfam03477
293826012302	ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505
293826012303	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
293826012304	Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200
293826012305	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
293826012306	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
293826012307	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
293826012308	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
293826012309	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
293826012310	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
293826012311	dimer interface [polypeptide binding]; other site
293826012312	putative anticodon binding site; other site
293826012313	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
293826012314	motif 1; other site
293826012315	active site
293826012316	motif 2; other site
293826012317	motif 3; other site
293826012318	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
293826012319	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
293826012320	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
293826012321	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
293826012322	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
293826012323	FMN binding site [chemical binding]; other site
293826012324	active site
293826012325	catalytic residues [active]
293826012326	substrate binding site [chemical binding]; other site
293826012327	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
293826012328	nucleotide binding site [chemical binding]; other site
293826012329	Predicted membrane protein [Function unknown]; Region: COG4684
293826012330	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826012331	dimer interface [polypeptide binding]; other site
293826012332	putative CheW interface [polypeptide binding]; other site
293826012333	Citrate transporter; Region: CitMHS; pfam03600
293826012334	fructuronate transporter; Provisional; Region: PRK10034; cl15264
293826012335	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
293826012336	Coenzyme A transferase; Region: CoA_trans; smart00882
293826012337	Coenzyme A transferase; Region: CoA_trans; cl17247
293826012338	PAS domain; Region: PAS_9; pfam13426
293826012339	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826012340	putative active site [active]
293826012341	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
293826012342	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826012343	Walker A motif; other site
293826012344	ATP binding site [chemical binding]; other site
293826012345	Walker B motif; other site
293826012346	arginine finger; other site
293826012347	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
293826012348	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
293826012349	Biotin operon repressor [Transcription]; Region: BirA; COG1654
293826012350	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
293826012351	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
293826012352	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
293826012353	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
293826012354	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
293826012355	carboxyltransferase (CT) interaction site; other site
293826012356	biotinylation site [posttranslational modification]; other site
293826012357	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458
293826012358	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
293826012359	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
293826012360	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
293826012361	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
293826012362	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
293826012363	dimer interface [polypeptide binding]; other site
293826012364	substrate binding site [chemical binding]; other site
293826012365	metal binding site [ion binding]; metal-binding site
293826012366	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
293826012367	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
293826012368	Walker A; other site
293826012369	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
293826012370	B12 binding site [chemical binding]; other site
293826012371	cobalt ligand [ion binding]; other site
293826012372	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
293826012373	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
293826012374	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826012375	Walker A motif; other site
293826012376	ATP binding site [chemical binding]; other site
293826012377	Walker B motif; other site
293826012378	arginine finger; other site
293826012379	Peptidase family M41; Region: Peptidase_M41; pfam01434
293826012380	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
293826012381	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
293826012382	Ligand Binding Site [chemical binding]; other site
293826012383	TilS substrate C-terminal domain; Region: TilS_C; smart00977
293826012384	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
293826012385	Catalytic domain of Protein Kinases; Region: PKc; cd00180
293826012386	active site
293826012387	ATP binding site [chemical binding]; other site
293826012388	substrate binding site [chemical binding]; other site
293826012389	activation loop (A-loop); other site
293826012390	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
293826012391	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
293826012392	metal ion-dependent adhesion site (MIDAS); other site
293826012393	B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067
293826012394	B12 binding site [chemical binding]; other site
293826012395	cobalt ligand [ion binding]; other site
293826012396	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
293826012397	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
293826012398	MutS domain III; Region: MutS_III; pfam05192
293826012399	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826012400	Walker A/P-loop; other site
293826012401	ATP binding site [chemical binding]; other site
293826012402	Q-loop/lid; other site
293826012403	ABC transporter signature motif; other site
293826012404	Walker B; other site
293826012405	D-loop; other site
293826012406	H-loop/switch region; other site
293826012407	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
293826012408	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
293826012409	FeS/SAM binding site; other site
293826012410	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
293826012411	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
293826012412	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
293826012413	NAD(P) binding site [chemical binding]; other site
293826012414	PAS fold; Region: PAS_4; pfam08448
293826012415	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826012416	putative active site [active]
293826012417	heme pocket [chemical binding]; other site
293826012418	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
293826012419	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826012420	Walker A motif; other site
293826012421	ATP binding site [chemical binding]; other site
293826012422	Walker B motif; other site
293826012423	arginine finger; other site
293826012424	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
293826012425	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
293826012426	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
293826012427	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
293826012428	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
293826012429	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
293826012430	putative active site [active]
293826012431	putative metal binding site [ion binding]; other site
293826012432	hydroxylamine reductase; Provisional; Region: PRK12310
293826012433	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
293826012434	ACS interaction site; other site
293826012435	CODH interaction site; other site
293826012436	metal cluster binding site [ion binding]; other site
293826012437	aspartate aminotransferase; Provisional; Region: PRK06348
293826012438	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
293826012439	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826012440	homodimer interface [polypeptide binding]; other site
293826012441	catalytic residue [active]
293826012442	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
293826012443	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
293826012444	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
293826012445	XdhC Rossmann domain; Region: XdhC_C; pfam13478
293826012446	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
293826012447	Ligand binding site; other site
293826012448	metal-binding site
293826012449	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
293826012450	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
293826012451	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
293826012452	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
293826012453	active site
293826012454	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
293826012455	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
293826012456	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
293826012457	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
293826012458	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
293826012459	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
293826012460	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
293826012461	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
293826012462	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
293826012463	N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228
293826012464	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
293826012465	active site
293826012466	putative substrate binding pocket [chemical binding]; other site
293826012467	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
293826012468	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
293826012469	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
293826012470	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
293826012471	active site
293826012472	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
293826012473	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
293826012474	Hexamer/Pentamer interface [polypeptide binding]; other site
293826012475	central pore; other site
293826012476	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
293826012477	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
293826012478	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
293826012479	Hexamer interface [polypeptide binding]; other site
293826012480	Hexagonal pore residue; other site
293826012481	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
293826012482	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
293826012483	Hexamer interface [polypeptide binding]; other site
293826012484	Hexagonal pore residue; other site
293826012485	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
293826012486	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
293826012487	Hexamer interface [polypeptide binding]; other site
293826012488	Hexagonal pore residue; other site
293826012489	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
293826012490	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
293826012491	Flavoprotein; Region: Flavoprotein; pfam02441
293826012492	Isochorismatase family; Region: Isochorismatase; pfam00857
293826012493	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
293826012494	catalytic triad [active]
293826012495	conserved cis-peptide bond; other site
293826012496	Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044
293826012497	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
293826012498	active site
293826012499	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
293826012500	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
293826012501	Potassium binding sites [ion binding]; other site
293826012502	Cesium cation binding sites [ion binding]; other site
293826012503	glutamate formiminotransferase; Region: FtcD; TIGR02024
293826012504	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
293826012505	Formiminotransferase domain; Region: FTCD; pfam02971
293826012506	Putative cyclase; Region: Cyclase; pfam04199
293826012507	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
293826012508	DRTGG domain; Region: DRTGG; pfam07085
293826012509	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
293826012510	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
293826012511	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
293826012512	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
293826012513	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
293826012514	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
293826012515	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
293826012516	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
293826012517	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
293826012518	Spore germination protein; Region: Spore_permease; cl17796
293826012519	Spore germination protein; Region: Spore_permease; cl17796
293826012520	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
293826012521	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
293826012522	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
293826012523	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
293826012524	active site
293826012525	Transcriptional regulators [Transcription]; Region: GntR; COG1802
293826012526	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826012527	DNA-binding site [nucleotide binding]; DNA binding site
293826012528	FCD domain; Region: FCD; pfam07729
293826012529	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
293826012530	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
293826012531	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
293826012532	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
293826012533	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
293826012534	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
293826012535	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826012536	carbamate kinase; Reviewed; Region: PRK12686
293826012537	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
293826012538	putative substrate binding site [chemical binding]; other site
293826012539	nucleotide binding site [chemical binding]; other site
293826012540	nucleotide binding site [chemical binding]; other site
293826012541	homodimer interface [polypeptide binding]; other site
293826012542	ornithine carbamoyltransferase; Validated; Region: PRK02102
293826012543	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
293826012544	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
293826012545	arginine deiminase; Provisional; Region: PRK01388
293826012546	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
293826012547	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
293826012548	Stage II sporulation protein; Region: SpoIID; pfam08486
293826012549	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
293826012550	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
293826012551	active site
293826012552	metal binding site [ion binding]; metal-binding site
293826012553	Transcriptional regulators [Transcription]; Region: MarR; COG1846
293826012554	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
293826012555	dimerization interface [polypeptide binding]; other site
293826012556	putative DNA binding site [nucleotide binding]; other site
293826012557	putative Zn2+ binding site [ion binding]; other site
293826012558	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
293826012559	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
293826012560	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
293826012561	dimer interface [polypeptide binding]; other site
293826012562	decamer (pentamer of dimers) interface [polypeptide binding]; other site
293826012563	catalytic triad [active]
293826012564	peroxidatic and resolving cysteines [active]
293826012565	multifunctional aminopeptidase A; Provisional; Region: PRK00913
293826012566	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
293826012567	interface (dimer of trimers) [polypeptide binding]; other site
293826012568	Substrate-binding/catalytic site; other site
293826012569	Zn-binding sites [ion binding]; other site
293826012570	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
293826012571	FMN-binding domain; Region: FMN_bind; pfam04205
293826012572	FMN-binding domain; Region: FMN_bind; pfam04205
293826012573	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
293826012574	PhoU domain; Region: PhoU; pfam01895
293826012575	PhoU domain; Region: PhoU; pfam01895
293826012576	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
293826012577	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
293826012578	Walker A/P-loop; other site
293826012579	ATP binding site [chemical binding]; other site
293826012580	Q-loop/lid; other site
293826012581	ABC transporter signature motif; other site
293826012582	Walker B; other site
293826012583	D-loop; other site
293826012584	H-loop/switch region; other site
293826012585	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
293826012586	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826012587	dimer interface [polypeptide binding]; other site
293826012588	conserved gate region; other site
293826012589	putative PBP binding loops; other site
293826012590	ABC-ATPase subunit interface; other site
293826012591	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
293826012592	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826012593	dimer interface [polypeptide binding]; other site
293826012594	conserved gate region; other site
293826012595	putative PBP binding loops; other site
293826012596	ABC-ATPase subunit interface; other site
293826012597	PBP superfamily domain; Region: PBP_like_2; cl17296
293826012598	metal-dependent hydrolase; Provisional; Region: PRK00685
293826012599	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
293826012600	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
293826012601	EamA-like transporter family; Region: EamA; pfam00892
293826012602	EamA-like transporter family; Region: EamA; pfam00892
293826012603	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
293826012604	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
293826012605	Walker A/P-loop; other site
293826012606	ATP binding site [chemical binding]; other site
293826012607	Q-loop/lid; other site
293826012608	ABC transporter signature motif; other site
293826012609	Walker B; other site
293826012610	D-loop; other site
293826012611	H-loop/switch region; other site
293826012612	TOBE domain; Region: TOBE_2; pfam08402
293826012613	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
293826012614	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826012615	dimer interface [polypeptide binding]; other site
293826012616	conserved gate region; other site
293826012617	putative PBP binding loops; other site
293826012618	ABC-ATPase subunit interface; other site
293826012619	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826012620	dimer interface [polypeptide binding]; other site
293826012621	conserved gate region; other site
293826012622	putative PBP binding loops; other site
293826012623	ABC-ATPase subunit interface; other site
293826012624	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
293826012625	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
293826012626	putative acyltransferase; Provisional; Region: PRK05790
293826012627	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
293826012628	dimer interface [polypeptide binding]; other site
293826012629	active site
293826012630	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
293826012631	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
293826012632	NAD(P) binding site [chemical binding]; other site
293826012633	active site
293826012634	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
293826012635	Domain of unknown function DUF20; Region: UPF0118; pfam01594
293826012636	Predicted membrane protein [Function unknown]; Region: COG2323
293826012637	tRNA pseudouridine synthase A; Reviewed; Region: PRK12434
293826012638	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
293826012639	dimerization interface 3.5A [polypeptide binding]; other site
293826012640	active site
293826012641	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
293826012642	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
293826012643	Cache domain; Region: Cache_1; pfam02743
293826012644	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
293826012645	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826012646	dimerization interface [polypeptide binding]; other site
293826012647	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826012648	dimer interface [polypeptide binding]; other site
293826012649	putative CheW interface [polypeptide binding]; other site
293826012650	Nitroreductase family; Region: Nitroreductase; pfam00881
293826012651	FMN binding site [chemical binding]; other site
293826012652	dimer interface [polypeptide binding]; other site
293826012653	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
293826012654	FMN binding site [chemical binding]; other site
293826012655	dimer interface [polypeptide binding]; other site
293826012656	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
293826012657	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
293826012658	active site
293826012659	metal binding site [ion binding]; metal-binding site
293826012660	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
293826012661	MoaE interaction surface [polypeptide binding]; other site
293826012662	MoeB interaction surface [polypeptide binding]; other site
293826012663	thiocarboxylated glycine; other site
293826012664	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
293826012665	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
293826012666	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
293826012667	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
293826012668	GAF domain; Region: GAF; pfam01590
293826012669	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826012670	putative active site [active]
293826012671	heme pocket [chemical binding]; other site
293826012672	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826012673	Walker A motif; other site
293826012674	ATP binding site [chemical binding]; other site
293826012675	Walker B motif; other site
293826012676	arginine finger; other site
293826012677	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
293826012678	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
293826012679	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
293826012680	Peptidase family M28; Region: Peptidase_M28; pfam04389
293826012681	metal binding site [ion binding]; metal-binding site
293826012682	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
293826012683	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
293826012684	putative [4Fe-4S] binding site [ion binding]; other site
293826012685	putative molybdopterin cofactor binding site [chemical binding]; other site
293826012686	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
293826012687	molybdopterin cofactor binding site; other site
293826012688	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
293826012689	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
293826012690	TPP-binding site [chemical binding]; other site
293826012691	dimer interface [polypeptide binding]; other site
293826012692	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
293826012693	PYR/PP interface [polypeptide binding]; other site
293826012694	dimer interface [polypeptide binding]; other site
293826012695	TPP binding site [chemical binding]; other site
293826012696	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
293826012697	dUTPase; Region: dUTPase_2; pfam08761
293826012698	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
293826012699	active site
293826012700	homodimer interface [polypeptide binding]; other site
293826012701	metal binding site [ion binding]; metal-binding site
293826012702	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
293826012703	hypothetical protein; Provisional; Region: PRK05590
293826012704	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
293826012705	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
293826012706	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
293826012707	Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172
293826012708	non-heme iron binding site [ion binding]; other site
293826012709	tetramer interface [polypeptide binding]; other site
293826012710	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
293826012711	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
293826012712	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
293826012713	putative active site [active]
293826012714	catalytic site [active]
293826012715	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
293826012716	putative active site [active]
293826012717	catalytic site [active]
293826012718	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
293826012719	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
293826012720	active site
293826012721	nucleophile elbow; other site
293826012722	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
293826012723	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
293826012724	dimer interface [polypeptide binding]; other site
293826012725	PYR/PP interface [polypeptide binding]; other site
293826012726	TPP binding site [chemical binding]; other site
293826012727	substrate binding site [chemical binding]; other site
293826012728	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
293826012729	Domain of unknown function; Region: EKR; smart00890
293826012730	4Fe-4S binding domain; Region: Fer4_6; pfam12837
293826012731	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
293826012732	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
293826012733	TPP-binding site [chemical binding]; other site
293826012734	dimer interface [polypeptide binding]; other site
293826012735	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
293826012736	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
293826012737	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
293826012738	Walker A/P-loop; other site
293826012739	ATP binding site [chemical binding]; other site
293826012740	Q-loop/lid; other site
293826012741	ABC transporter signature motif; other site
293826012742	Walker B; other site
293826012743	D-loop; other site
293826012744	H-loop/switch region; other site
293826012745	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
293826012746	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
293826012747	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
293826012748	dimer interface [polypeptide binding]; other site
293826012749	active site
293826012750	Hemerythrin; Region: Hemerythrin; cd12107
293826012751	Fe binding site [ion binding]; other site
293826012752	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
293826012753	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
293826012754	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
293826012755	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
293826012756	[2Fe-2S] cluster binding site [ion binding]; other site
293826012757	Protein of unknown function (DUF458); Region: DUF458; pfam04308
293826012758	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
293826012759	GAF domain; Region: GAF; cl17456
293826012760	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
293826012761	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826012762	putative active site [active]
293826012763	heme pocket [chemical binding]; other site
293826012764	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826012765	Walker A motif; other site
293826012766	ATP binding site [chemical binding]; other site
293826012767	Walker B motif; other site
293826012768	arginine finger; other site
293826012769	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
293826012770	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
293826012771	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
293826012772	FMN binding site [chemical binding]; other site
293826012773	substrate binding site [chemical binding]; other site
293826012774	putative catalytic residue [active]
293826012775	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
293826012776	ABC-2 type transporter; Region: ABC2_membrane; cl17235
293826012777	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
293826012778	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
293826012779	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
293826012780	Walker A/P-loop; other site
293826012781	ATP binding site [chemical binding]; other site
293826012782	Q-loop/lid; other site
293826012783	ABC transporter signature motif; other site
293826012784	Walker B; other site
293826012785	D-loop; other site
293826012786	H-loop/switch region; other site
293826012787	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
293826012788	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
293826012789	MutS domain III; Region: MutS_III; pfam05192
293826012790	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
293826012791	Walker A/P-loop; other site
293826012792	ATP binding site [chemical binding]; other site
293826012793	Q-loop/lid; other site
293826012794	ABC transporter signature motif; other site
293826012795	Walker B; other site
293826012796	D-loop; other site
293826012797	H-loop/switch region; other site
293826012798	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826012799	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
293826012800	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
293826012801	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
293826012802	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826012803	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826012804	DNA binding residues [nucleotide binding]
293826012805	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
293826012806	Integrase core domain; Region: rve; pfam00665
293826012807	transposase/IS protein; Provisional; Region: PRK09183
293826012808	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826012809	Walker A motif; other site
293826012810	ATP binding site [chemical binding]; other site
293826012811	Walker B motif; other site
293826012812	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
293826012813	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
293826012814	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
293826012815	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
293826012816	DNA binding residues [nucleotide binding]
293826012817	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
293826012818	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
293826012819	ATP binding site [chemical binding]; other site
293826012820	putative Mg++ binding site [ion binding]; other site
293826012821	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
293826012822	nucleotide binding region [chemical binding]; other site
293826012823	ATP-binding site [chemical binding]; other site
293826012824	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
293826012825	HRDC domain; Region: HRDC; pfam00570
293826012826	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
293826012827	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
293826012828	dimer interface [polypeptide binding]; other site
293826012829	active site
293826012830	metal binding site [ion binding]; metal-binding site
293826012831	glutathione binding site [chemical binding]; other site
293826012832	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
293826012833	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
293826012834	RNA binding surface [nucleotide binding]; other site
293826012835	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
293826012836	probable active site [active]
293826012837	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
293826012838	DEAD-like helicases superfamily; Region: DEXDc; smart00487
293826012839	ATP binding site [chemical binding]; other site
293826012840	putative Mg++ binding site [ion binding]; other site
293826012841	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
293826012842	nucleotide binding region [chemical binding]; other site
293826012843	ATP-binding site [chemical binding]; other site
293826012844	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
293826012845	Domain of unknown function (DUF4392); Region: DUF4392; pfam14336
293826012846	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
293826012847	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
293826012848	Domain of unknown function (DUF1850); Region: DUF1850; pfam08905
293826012849	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
293826012850	DctM-like transporters; Region: DctM; pfam06808
293826012851	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
293826012852	active site residue [active]
293826012853	Transcriptional regulator [Transcription]; Region: LysR; COG0583
293826012854	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
293826012855	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
293826012856	putative dimerization interface [polypeptide binding]; other site
293826012857	Sulphur transport; Region: Sulf_transp; pfam04143
293826012858	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
293826012859	CPxP  motif; other site
293826012860	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
293826012861	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
293826012862	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
293826012863	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
293826012864	EamA-like transporter family; Region: EamA; pfam00892
293826012865	EamA-like transporter family; Region: EamA; pfam00892
293826012866	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826012867	dimerization interface [polypeptide binding]; other site
293826012868	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
293826012869	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
293826012870	dimer interface [polypeptide binding]; other site
293826012871	putative CheW interface [polypeptide binding]; other site
293826012872	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
293826012873	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826012874	Walker A/P-loop; other site
293826012875	ATP binding site [chemical binding]; other site
293826012876	Q-loop/lid; other site
293826012877	ABC transporter signature motif; other site
293826012878	Walker B; other site
293826012879	D-loop; other site
293826012880	H-loop/switch region; other site
293826012881	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
293826012882	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
293826012883	Walker A/P-loop; other site
293826012884	ATP binding site [chemical binding]; other site
293826012885	Q-loop/lid; other site
293826012886	ABC transporter signature motif; other site
293826012887	Walker B; other site
293826012888	D-loop; other site
293826012889	H-loop/switch region; other site
293826012890	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
293826012891	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
293826012892	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826012893	dimer interface [polypeptide binding]; other site
293826012894	conserved gate region; other site
293826012895	putative PBP binding loops; other site
293826012896	ABC-ATPase subunit interface; other site
293826012897	nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789
293826012898	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826012899	dimer interface [polypeptide binding]; other site
293826012900	conserved gate region; other site
293826012901	putative PBP binding loops; other site
293826012902	ABC-ATPase subunit interface; other site
293826012903	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
293826012904	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
293826012905	substrate binding site [chemical binding]; other site
293826012906	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
293826012907	Major Facilitator Superfamily; Region: MFS_1; pfam07690
293826012908	putative substrate translocation pore; other site
293826012909	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
293826012910	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
293826012911	active site
293826012912	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
293826012913	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
293826012914	putative metal binding site [ion binding]; other site
293826012915	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
293826012916	active site
293826012917	metal binding site [ion binding]; metal-binding site
293826012918	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
293826012919	Coenzyme A binding pocket [chemical binding]; other site
293826012920	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
293826012921	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
293826012922	DNA-binding site [nucleotide binding]; DNA binding site
293826012923	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
293826012924	pyridoxal 5'-phosphate binding site [chemical binding]; other site
293826012925	homodimer interface [polypeptide binding]; other site
293826012926	catalytic residue [active]
293826012927	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
293826012928	EamA-like transporter family; Region: EamA; pfam00892
293826012929	EamA-like transporter family; Region: EamA; pfam00892
293826012930	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826012931	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826012932	active site
293826012933	phosphorylation site [posttranslational modification]
293826012934	intermolecular recognition site; other site
293826012935	dimerization interface [polypeptide binding]; other site
293826012936	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826012937	DNA binding site [nucleotide binding]
293826012938	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
293826012939	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826012940	dimerization interface [polypeptide binding]; other site
293826012941	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826012942	dimer interface [polypeptide binding]; other site
293826012943	phosphorylation site [posttranslational modification]
293826012944	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826012945	ATP binding site [chemical binding]; other site
293826012946	Mg2+ binding site [ion binding]; other site
293826012947	G-X-G motif; other site
293826012948	Transposase; Region: HTH_Tnp_1; cl17663
293826012949	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
293826012950	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
293826012951	Penicillinase repressor; Region: Pencillinase_R; cl17580
293826012952	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
293826012953	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
293826012954	Walker A/P-loop; other site
293826012955	ATP binding site [chemical binding]; other site
293826012956	Q-loop/lid; other site
293826012957	ABC transporter signature motif; other site
293826012958	Walker B; other site
293826012959	D-loop; other site
293826012960	H-loop/switch region; other site
293826012961	TOBE domain; Region: TOBE; pfam03459
293826012962	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
293826012963	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
293826012964	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
293826012965	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
293826012966	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
293826012967	HlyD family secretion protein; Region: HlyD_3; pfam13437
293826012968	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
293826012969	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826012970	dimer interface [polypeptide binding]; other site
293826012971	conserved gate region; other site
293826012972	putative PBP binding loops; other site
293826012973	ABC-ATPase subunit interface; other site
293826012974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
293826012975	dimer interface [polypeptide binding]; other site
293826012976	conserved gate region; other site
293826012977	putative PBP binding loops; other site
293826012978	ABC-ATPase subunit interface; other site
293826012979	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
293826012980	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
293826012981	Walker A/P-loop; other site
293826012982	ATP binding site [chemical binding]; other site
293826012983	Q-loop/lid; other site
293826012984	ABC transporter signature motif; other site
293826012985	Walker B; other site
293826012986	D-loop; other site
293826012987	H-loop/switch region; other site
293826012988	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
293826012989	FtsX-like permease family; Region: FtsX; pfam02687
293826012990	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826012991	dimerization interface [polypeptide binding]; other site
293826012992	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826012993	dimer interface [polypeptide binding]; other site
293826012994	phosphorylation site [posttranslational modification]
293826012995	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826012996	ATP binding site [chemical binding]; other site
293826012997	Mg2+ binding site [ion binding]; other site
293826012998	G-X-G motif; other site
293826012999	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826013000	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826013001	active site
293826013002	phosphorylation site [posttranslational modification]
293826013003	intermolecular recognition site; other site
293826013004	dimerization interface [polypeptide binding]; other site
293826013005	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826013006	DNA binding site [nucleotide binding]
293826013007	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
293826013008	YyzF-like protein; Region: YyzF; pfam14116
293826013009	serine endoprotease; Provisional; Region: PRK10898
293826013010	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
293826013011	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
293826013012	protein binding site [polypeptide binding]; other site
293826013013	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
293826013014	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
293826013015	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
293826013016	hinge; other site
293826013017	active site
293826013018	YycH protein; Region: YycI; cl02015
293826013019	YycH protein; Region: YycH; pfam07435
293826013020	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
293826013021	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
293826013022	dimerization interface [polypeptide binding]; other site
293826013023	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
293826013024	putative active site [active]
293826013025	heme pocket [chemical binding]; other site
293826013026	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
293826013027	dimer interface [polypeptide binding]; other site
293826013028	phosphorylation site [posttranslational modification]
293826013029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
293826013030	ATP binding site [chemical binding]; other site
293826013031	Mg2+ binding site [ion binding]; other site
293826013032	G-X-G motif; other site
293826013033	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
293826013034	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
293826013035	active site
293826013036	phosphorylation site [posttranslational modification]
293826013037	intermolecular recognition site; other site
293826013038	dimerization interface [polypeptide binding]; other site
293826013039	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
293826013040	DNA binding site [nucleotide binding]
293826013041	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
293826013042	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
293826013043	active site
293826013044	catalytic triad [active]
293826013045	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
293826013046	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
293826013047	G5 domain; Region: G5; pfam07501
293826013048	Peptidase family M23; Region: Peptidase_M23; pfam01551
293826013049	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
293826013050	Zn binding site [ion binding]; other site
293826013051	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
293826013052	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
293826013053	DNA replication protein DnaC; Validated; Region: PRK06835
293826013054	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826013055	Walker A motif; other site
293826013056	ATP binding site [chemical binding]; other site
293826013057	Walker B motif; other site
293826013058	arginine finger; other site
293826013059	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
293826013060	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
293826013061	GDP-binding site [chemical binding]; other site
293826013062	ACT binding site; other site
293826013063	IMP binding site; other site
293826013064	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
293826013065	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
293826013066	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
293826013067	Coenzyme A binding pocket [chemical binding]; other site
293826013068	replicative DNA helicase; Region: DnaB; TIGR00665
293826013069	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
293826013070	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
293826013071	Walker A motif; other site
293826013072	ATP binding site [chemical binding]; other site
293826013073	Walker B motif; other site
293826013074	DNA binding loops [nucleotide binding]
293826013075	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
293826013076	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
293826013077	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
293826013078	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
293826013079	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
293826013080	DHH family; Region: DHH; pfam01368
293826013081	DHHA1 domain; Region: DHHA1; pfam02272
293826013082	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
293826013083	MazG-like family; Region: MazG-like; pfam12643
293826013084	Predicted membrane protein [Function unknown]; Region: COG4129
293826013085	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
293826013086	SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441
293826013087	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
293826013088	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
293826013089	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
293826013090	putative active site [active]
293826013091	PhoH-like protein; Region: PhoH; pfam02562
293826013092	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
293826013093	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
293826013094	recombination protein RecR; Reviewed; Region: recR; PRK00076
293826013095	RecR protein; Region: RecR; pfam02132
293826013096	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
293826013097	putative active site [active]
293826013098	putative metal-binding site [ion binding]; other site
293826013099	tetramer interface [polypeptide binding]; other site
293826013100	hypothetical protein; Validated; Region: PRK00153
293826013101	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
293826013102	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
293826013103	Walker A motif; other site
293826013104	ATP binding site [chemical binding]; other site
293826013105	Walker B motif; other site
293826013106	arginine finger; other site
293826013107	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
293826013108	Colicin V production protein; Region: Colicin_V; pfam02674
293826013109	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
293826013110	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
293826013111	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
293826013112	Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214
293826013113	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
293826013114	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
293826013115	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
293826013116	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
293826013117	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
293826013118	catalytic residue [active]
293826013119	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
293826013120	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
293826013121	ParB-like nuclease domain; Region: ParB; smart00470
293826013122	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
293826013123	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
293826013124	P-loop; other site
293826013125	Magnesium ion binding site [ion binding]; other site
293826013126	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
293826013127	Magnesium ion binding site [ion binding]; other site
293826013128	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
293826013129	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
293826013130	ParB-like nuclease domain; Region: ParBc; pfam02195
293826013131	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
293826013132	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
293826013133	S-adenosylmethionine binding site [chemical binding]; other site
293826013134	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
293826013135	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
293826013136	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
293826013137	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
293826013138	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
293826013139	trmE is a tRNA modification GTPase; Region: trmE; cd04164
293826013140	G1 box; other site
293826013141	GTP/Mg2+ binding site [chemical binding]; other site
293826013142	Switch I region; other site
293826013143	G2 box; other site
293826013144	Switch II region; other site
293826013145	G3 box; other site
293826013146	G4 box; other site
293826013147	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
293826013148	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
293826013149	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
293826013150	G-X-X-G motif; other site
293826013151	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
293826013152	RxxxH motif; other site
293826013153	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
293826013154	Haemolytic domain; Region: Haemolytic; pfam01809
293826013155	ribonuclease P; Reviewed; Region: rnpA; PRK00499