-- dump date 20140618_194413 -- class Genbank::misc_feature -- table misc_feature_note -- id note 572477000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 572477000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 572477000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477000004 Walker A motif; other site 572477000005 ATP binding site [chemical binding]; other site 572477000006 Walker B motif; other site 572477000007 arginine finger; other site 572477000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 572477000009 DnaA box-binding interface [nucleotide binding]; other site 572477000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 572477000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 572477000012 putative DNA binding surface [nucleotide binding]; other site 572477000013 dimer interface [polypeptide binding]; other site 572477000014 beta-clamp/clamp loader binding surface; other site 572477000015 beta-clamp/translesion DNA polymerase binding surface; other site 572477000016 recombination protein F; Reviewed; Region: recF; PRK00064 572477000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477000018 Walker A/P-loop; other site 572477000019 ATP binding site [chemical binding]; other site 572477000020 Q-loop/lid; other site 572477000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477000022 ABC transporter signature motif; other site 572477000023 Walker B; other site 572477000024 D-loop; other site 572477000025 H-loop/switch region; other site 572477000026 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 572477000027 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572477000028 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572477000029 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572477000030 Walker A/P-loop; other site 572477000031 ATP binding site [chemical binding]; other site 572477000032 Q-loop/lid; other site 572477000033 ABC transporter signature motif; other site 572477000034 Walker B; other site 572477000035 D-loop; other site 572477000036 H-loop/switch region; other site 572477000037 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 572477000038 Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742 572477000039 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 572477000040 putative dimer interface [polypeptide binding]; other site 572477000041 Predicted membrane protein [Function unknown]; Region: COG3212 572477000042 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 572477000043 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572477000044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477000045 active site 572477000046 phosphorylation site [posttranslational modification] 572477000047 intermolecular recognition site; other site 572477000048 dimerization interface [polypeptide binding]; other site 572477000049 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572477000050 DNA binding site [nucleotide binding] 572477000051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477000052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477000053 ATP binding site [chemical binding]; other site 572477000054 Mg2+ binding site [ion binding]; other site 572477000055 G-X-G motif; other site 572477000056 Outer membrane efflux protein; Region: OEP; pfam02321 572477000057 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 572477000058 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 572477000059 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 572477000060 HlyD family secretion protein; Region: HlyD_3; pfam13437 572477000061 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 572477000062 Protein of unknown function (DUF3240); Region: DUF3240; pfam11582 572477000063 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 572477000064 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 572477000065 Cation efflux family; Region: Cation_efflux; cl00316 572477000066 Dihaem cytochrome c; Region: DHC; pfam09626 572477000067 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 572477000068 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 572477000069 Dihaem cytochrome c; Region: DHC; pfam09626 572477000070 Predicted membrane protein [Function unknown]; Region: COG3212 572477000071 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 572477000072 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572477000073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477000074 active site 572477000075 phosphorylation site [posttranslational modification] 572477000076 intermolecular recognition site; other site 572477000077 dimerization interface [polypeptide binding]; other site 572477000078 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572477000079 DNA binding site [nucleotide binding] 572477000080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477000081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477000082 ATP binding site [chemical binding]; other site 572477000083 G-X-G motif; other site 572477000084 Cation transport protein; Region: TrkH; cl17365 572477000085 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 572477000086 DsrC like protein; Region: DsrC; pfam04358 572477000087 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 572477000088 Predicted membrane protein [Function unknown]; Region: COG2860 572477000089 UPF0126 domain; Region: UPF0126; pfam03458 572477000090 UPF0126 domain; Region: UPF0126; pfam03458 572477000091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477000092 ATP binding site [chemical binding]; other site 572477000093 Mg2+ binding site [ion binding]; other site 572477000094 G-X-G motif; other site 572477000095 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 572477000096 anchoring element; other site 572477000097 dimer interface [polypeptide binding]; other site 572477000098 ATP binding site [chemical binding]; other site 572477000099 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 572477000100 active site 572477000101 metal binding site [ion binding]; metal-binding site 572477000102 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 572477000103 protein-splicing catalytic site; other site 572477000104 thioester formation/cholesterol transfer; other site 572477000105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572477000106 non-specific DNA binding site [nucleotide binding]; other site 572477000107 salt bridge; other site 572477000108 sequence-specific DNA binding site [nucleotide binding]; other site 572477000109 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 572477000110 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 572477000111 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 572477000112 active site 572477000113 metal binding site [ion binding]; metal-binding site 572477000114 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 572477000115 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 572477000116 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572477000117 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 572477000118 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 572477000119 active site 572477000120 dimer interface [polypeptide binding]; other site 572477000121 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 572477000122 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 572477000123 active site 572477000124 FMN binding site [chemical binding]; other site 572477000125 substrate binding site [chemical binding]; other site 572477000126 3Fe-4S cluster binding site [ion binding]; other site 572477000127 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 572477000128 domain interface; other site 572477000129 WYL domain; Region: WYL; pfam13280 572477000130 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 572477000131 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 572477000132 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 572477000133 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572477000134 P-loop; other site 572477000135 Magnesium ion binding site [ion binding]; other site 572477000136 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572477000137 Magnesium ion binding site [ion binding]; other site 572477000138 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 572477000139 ParB-like nuclease domain; Region: ParB; smart00470 572477000140 ATP synthase I chain; Region: ATP_synt_I; cl09170 572477000141 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 572477000142 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 572477000143 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 572477000144 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 572477000145 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 572477000146 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 572477000147 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 572477000148 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 572477000149 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 572477000150 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 572477000151 beta subunit interaction interface [polypeptide binding]; other site 572477000152 Walker A motif; other site 572477000153 ATP binding site [chemical binding]; other site 572477000154 Walker B motif; other site 572477000155 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 572477000156 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 572477000157 core domain interface [polypeptide binding]; other site 572477000158 delta subunit interface [polypeptide binding]; other site 572477000159 epsilon subunit interface [polypeptide binding]; other site 572477000160 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 572477000161 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 572477000162 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 572477000163 alpha subunit interaction interface [polypeptide binding]; other site 572477000164 Walker A motif; other site 572477000165 ATP binding site [chemical binding]; other site 572477000166 Walker B motif; other site 572477000167 inhibitor binding site; inhibition site 572477000168 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 572477000169 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 572477000170 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 572477000171 gamma subunit interface [polypeptide binding]; other site 572477000172 epsilon subunit interface [polypeptide binding]; other site 572477000173 LBP interface [polypeptide binding]; other site 572477000174 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 572477000175 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 572477000176 Substrate binding site; other site 572477000177 Mg++ binding site; other site 572477000178 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 572477000179 active site 572477000180 substrate binding site [chemical binding]; other site 572477000181 CoA binding site [chemical binding]; other site 572477000182 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 572477000183 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 572477000184 glutaminase active site [active] 572477000185 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 572477000186 dimer interface [polypeptide binding]; other site 572477000187 active site 572477000188 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 572477000189 dimer interface [polypeptide binding]; other site 572477000190 active site 572477000191 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 572477000192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572477000193 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 572477000194 NAD(P) binding site [chemical binding]; other site 572477000195 active site 572477000196 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 572477000197 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572477000198 active site 572477000199 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572477000200 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572477000201 SOUL heme-binding protein; Region: SOUL; pfam04832 572477000202 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 572477000203 putative active site [active] 572477000204 dimerization interface [polypeptide binding]; other site 572477000205 putative tRNAtyr binding site [nucleotide binding]; other site 572477000206 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 572477000207 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 572477000208 TAP-like protein; Region: Abhydrolase_4; pfam08386 572477000209 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 572477000210 ThiC-associated domain; Region: ThiC-associated; pfam13667 572477000211 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 572477000212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 572477000213 phosphorylation site [posttranslational modification] 572477000214 intermolecular recognition site; other site 572477000215 Response regulator receiver domain; Region: Response_reg; pfam00072 572477000216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477000217 active site 572477000218 phosphorylation site [posttranslational modification] 572477000219 intermolecular recognition site; other site 572477000220 dimerization interface [polypeptide binding]; other site 572477000221 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477000222 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477000223 metal binding site [ion binding]; metal-binding site 572477000224 I-site; other site 572477000225 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477000226 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 572477000227 poly(R)-hydroxyalkanoic acid synthase, class III, PhaE subunit; Region: PHA_synth_III_E; TIGR01834 572477000228 putative acyltransferase; Provisional; Region: PRK05790 572477000229 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 572477000230 dimer interface [polypeptide binding]; other site 572477000231 active site 572477000232 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 572477000233 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 572477000234 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 572477000235 Phasin protein; Region: Phasin_2; cl11491 572477000236 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 572477000237 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 572477000238 NAD(P) binding site [chemical binding]; other site 572477000239 homotetramer interface [polypeptide binding]; other site 572477000240 homodimer interface [polypeptide binding]; other site 572477000241 active site 572477000242 Uncharacterized conserved protein [Function unknown]; Region: COG0327 572477000243 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 572477000244 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 572477000245 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 572477000246 [2Fe-2S] cluster binding site [ion binding]; other site 572477000247 cytochrome b; Provisional; Region: CYTB; MTH00145 572477000248 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 572477000249 Qi binding site; other site 572477000250 intrachain domain interface; other site 572477000251 interchain domain interface [polypeptide binding]; other site 572477000252 heme bH binding site [chemical binding]; other site 572477000253 heme bL binding site [chemical binding]; other site 572477000254 Qo binding site; other site 572477000255 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 572477000256 interchain domain interface [polypeptide binding]; other site 572477000257 intrachain domain interface; other site 572477000258 Qi binding site; other site 572477000259 Qo binding site; other site 572477000260 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 572477000261 stringent starvation protein A; Provisional; Region: sspA; PRK09481 572477000262 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 572477000263 C-terminal domain interface [polypeptide binding]; other site 572477000264 putative GSH binding site (G-site) [chemical binding]; other site 572477000265 dimer interface [polypeptide binding]; other site 572477000266 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 572477000267 dimer interface [polypeptide binding]; other site 572477000268 N-terminal domain interface [polypeptide binding]; other site 572477000269 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 572477000270 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 572477000271 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 572477000272 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 572477000273 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 572477000274 substrate binding site [chemical binding]; other site 572477000275 ligand binding site [chemical binding]; other site 572477000276 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 572477000277 substrate binding site [chemical binding]; other site 572477000278 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 572477000279 Predicted membrane protein [Function unknown]; Region: COG1238 572477000280 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 572477000281 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572477000282 catalytic residues [active] 572477000283 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 572477000284 SelR domain; Region: SelR; pfam01641 572477000285 Putative motility protein; Region: YjfB_motility; pfam14070 572477000286 recombination factor protein RarA; Reviewed; Region: PRK13342 572477000287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477000288 Walker A motif; other site 572477000289 ATP binding site [chemical binding]; other site 572477000290 Walker B motif; other site 572477000291 arginine finger; other site 572477000292 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 572477000293 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 572477000294 hypothetical protein; Provisional; Region: PRK04233 572477000295 SEC-C motif; Region: SEC-C; pfam02810 572477000296 CHAP domain; Region: CHAP; cl17642 572477000297 Cytochrome c [Energy production and conversion]; Region: COG3258 572477000298 Cytochrome c; Region: Cytochrom_C; pfam00034 572477000299 Cupin domain; Region: Cupin_2; pfam07883 572477000300 methylcitrate synthase; Provisional; Region: PRK12351 572477000301 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 572477000302 oxalacetate binding site [chemical binding]; other site 572477000303 citrylCoA binding site [chemical binding]; other site 572477000304 coenzyme A binding site [chemical binding]; other site 572477000305 catalytic triad [active] 572477000306 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 572477000307 tetramer interface [polypeptide binding]; other site 572477000308 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 572477000309 active site 572477000310 Mg2+/Mn2+ binding site [ion binding]; other site 572477000311 Transcriptional regulators [Transcription]; Region: GntR; COG1802 572477000312 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572477000313 DNA-binding site [nucleotide binding]; DNA binding site 572477000314 FCD domain; Region: FCD; pfam07729 572477000315 Initiator Replication protein; Region: Rep_3; pfam01051 572477000316 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 572477000317 GIY-YIG motif/motif A; other site 572477000318 putative active site [active] 572477000319 putative metal binding site [ion binding]; other site 572477000320 LabA_like proteins; Region: LabA_like; cd06167 572477000321 putative metal binding site [ion binding]; other site 572477000322 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 572477000323 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572477000324 inhibitor-cofactor binding pocket; inhibition site 572477000325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477000326 catalytic residue [active] 572477000327 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 572477000328 thiamine phosphate binding site [chemical binding]; other site 572477000329 active site 572477000330 pyrophosphate binding site [ion binding]; other site 572477000331 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 572477000332 substrate binding site [chemical binding]; other site 572477000333 dimer interface [polypeptide binding]; other site 572477000334 ATP binding site [chemical binding]; other site 572477000335 Rubredoxin [Energy production and conversion]; Region: COG1773 572477000336 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 572477000337 iron binding site [ion binding]; other site 572477000338 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 572477000339 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 572477000340 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 572477000341 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 572477000342 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 572477000343 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 572477000344 active site 572477000345 HIGH motif; other site 572477000346 dimer interface [polypeptide binding]; other site 572477000347 KMSKS motif; other site 572477000348 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572477000349 RNA binding surface [nucleotide binding]; other site 572477000350 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 572477000351 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 572477000352 active site 572477000353 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572477000354 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 572477000355 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 572477000356 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 572477000357 putative acyl-acceptor binding pocket; other site 572477000358 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 572477000359 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 572477000360 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 572477000361 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 572477000362 putative active site [active] 572477000363 Ap4A binding site [chemical binding]; other site 572477000364 nudix motif; other site 572477000365 putative metal binding site [ion binding]; other site 572477000366 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 572477000367 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 572477000368 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 572477000369 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 572477000370 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 572477000371 FAD binding domain; Region: FAD_binding_4; pfam01565 572477000372 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 572477000373 BON domain; Region: BON; pfam04972 572477000374 BON domain; Region: BON; pfam04972 572477000375 hypothetical protein; Reviewed; Region: PRK12497 572477000376 LppC putative lipoprotein; Region: LppC; pfam04348 572477000377 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 572477000378 putative ligand binding site [chemical binding]; other site 572477000379 Predicted methyltransferases [General function prediction only]; Region: COG0313 572477000380 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 572477000381 putative SAM binding site [chemical binding]; other site 572477000382 putative homodimer interface [polypeptide binding]; other site 572477000383 cell division protein MraZ; Reviewed; Region: PRK00326 572477000384 MraZ protein; Region: MraZ; pfam02381 572477000385 MraZ protein; Region: MraZ; pfam02381 572477000386 MraW methylase family; Region: Methyltransf_5; cl17771 572477000387 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 572477000388 Cell division protein FtsL; Region: FtsL; pfam04999 572477000389 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 572477000390 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572477000391 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572477000392 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 572477000393 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 572477000394 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572477000395 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572477000396 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 572477000397 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 572477000398 Mg++ binding site [ion binding]; other site 572477000399 putative catalytic motif [active] 572477000400 putative substrate binding site [chemical binding]; other site 572477000401 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 572477000402 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 572477000403 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572477000404 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572477000405 cell division protein FtsW; Region: ftsW; TIGR02614 572477000406 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 572477000407 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 572477000408 active site 572477000409 homodimer interface [polypeptide binding]; other site 572477000410 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 572477000411 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 572477000412 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572477000413 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572477000414 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 572477000415 FAD binding domain; Region: FAD_binding_4; pfam01565 572477000416 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 572477000417 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 572477000418 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 572477000419 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572477000420 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 572477000421 Cell division protein FtsQ; Region: FtsQ; pfam03799 572477000422 cell division protein FtsA; Region: ftsA; TIGR01174 572477000423 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 572477000424 nucleotide binding site [chemical binding]; other site 572477000425 Cell division protein FtsA; Region: FtsA; pfam14450 572477000426 cell division protein FtsZ; Validated; Region: PRK09330 572477000427 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 572477000428 nucleotide binding site [chemical binding]; other site 572477000429 SulA interaction site; other site 572477000430 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 572477000431 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 572477000432 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 572477000433 Protein of unknown function (DUF721); Region: DUF721; pfam05258 572477000434 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572477000435 Peptidase family M23; Region: Peptidase_M23; pfam01551 572477000436 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 572477000437 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 572477000438 SEC-C motif; Region: SEC-C; pfam02810 572477000439 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 572477000440 heterotetramer interface [polypeptide binding]; other site 572477000441 active site pocket [active] 572477000442 cleavage site 572477000443 hypothetical protein; Provisional; Region: PRK08999 572477000444 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 572477000445 active site 572477000446 8-oxo-dGMP binding site [chemical binding]; other site 572477000447 nudix motif; other site 572477000448 metal binding site [ion binding]; metal-binding site 572477000449 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 572477000450 thiamine phosphate binding site [chemical binding]; other site 572477000451 active site 572477000452 pyrophosphate binding site [ion binding]; other site 572477000453 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 572477000454 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 572477000455 catalytic residues [active] 572477000456 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 572477000457 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 572477000458 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 572477000459 ApbE family; Region: ApbE; pfam02424 572477000460 Domain of unknown function (DUF329); Region: DUF329; pfam03884 572477000461 hypothetical protein; Provisional; Region: PRK05287 572477000462 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 572477000463 hypothetical protein; Validated; Region: PRK00110 572477000464 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 572477000465 active site 572477000466 putative DNA-binding cleft [nucleotide binding]; other site 572477000467 dimer interface [polypeptide binding]; other site 572477000468 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 572477000469 RuvA N terminal domain; Region: RuvA_N; pfam01330 572477000470 PAS fold; Region: PAS_4; pfam08448 572477000471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477000472 putative active site [active] 572477000473 heme pocket [chemical binding]; other site 572477000474 PAS fold; Region: PAS_4; pfam08448 572477000475 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477000476 putative active site [active] 572477000477 heme pocket [chemical binding]; other site 572477000478 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477000479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477000480 metal binding site [ion binding]; metal-binding site 572477000481 active site 572477000482 I-site; other site 572477000483 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 572477000484 FAD binding domain; Region: FAD_binding_4; pfam01565 572477000485 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 572477000486 Cysteine-rich domain; Region: CCG; pfam02754 572477000487 Cysteine-rich domain; Region: CCG; pfam02754 572477000488 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 572477000489 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 572477000490 CoA-binding site [chemical binding]; other site 572477000491 ATP-binding [chemical binding]; other site 572477000492 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 572477000493 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 572477000494 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 572477000495 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 572477000496 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 572477000497 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 572477000498 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 572477000499 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 572477000500 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 572477000501 Walker A motif; other site 572477000502 ATP binding site [chemical binding]; other site 572477000503 Walker B motif; other site 572477000504 LabA_like proteins; Region: LabA; cd10911 572477000505 Uncharacterized conserved protein [Function unknown]; Region: COG1432 572477000506 putative metal binding site [ion binding]; other site 572477000507 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 572477000508 RNA binding site [nucleotide binding]; other site 572477000509 acetyl-CoA synthetase; Provisional; Region: PRK00174 572477000510 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 572477000511 active site 572477000512 CoA binding site [chemical binding]; other site 572477000513 acyl-activating enzyme (AAE) consensus motif; other site 572477000514 AMP binding site [chemical binding]; other site 572477000515 acetate binding site [chemical binding]; other site 572477000516 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 572477000517 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 572477000518 active site 572477000519 catalytic site [active] 572477000520 substrate binding site [chemical binding]; other site 572477000521 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 572477000522 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572477000523 ligand binding site [chemical binding]; other site 572477000524 flexible hinge region; other site 572477000525 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 572477000526 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 572477000527 metal binding triad; other site 572477000528 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 572477000529 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 572477000530 glutamine binding [chemical binding]; other site 572477000531 catalytic triad [active] 572477000532 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 572477000533 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 572477000534 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 572477000535 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 572477000536 active site 572477000537 ribulose/triose binding site [chemical binding]; other site 572477000538 phosphate binding site [ion binding]; other site 572477000539 substrate (anthranilate) binding pocket [chemical binding]; other site 572477000540 product (indole) binding pocket [chemical binding]; other site 572477000541 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 572477000542 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572477000543 ligand binding site [chemical binding]; other site 572477000544 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 572477000545 putative switch regulator; other site 572477000546 non-specific DNA interactions [nucleotide binding]; other site 572477000547 DNA binding site [nucleotide binding] 572477000548 sequence specific DNA binding site [nucleotide binding]; other site 572477000549 putative cAMP binding site [chemical binding]; other site 572477000550 OsmC-like protein; Region: OsmC; cl00767 572477000551 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 572477000552 diiron binding motif [ion binding]; other site 572477000553 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572477000554 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 572477000555 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 572477000556 Cysteine-rich domain; Region: CCG; pfam02754 572477000557 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 572477000558 dimer interface [polypeptide binding]; other site 572477000559 [2Fe-2S] cluster binding site [ion binding]; other site 572477000560 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 572477000561 23S rRNA interface [nucleotide binding]; other site 572477000562 L3 interface [polypeptide binding]; other site 572477000563 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 572477000564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 572477000565 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 572477000566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572477000567 ATP binding site [chemical binding]; other site 572477000568 putative Mg++ binding site [ion binding]; other site 572477000569 T5orf172 domain; Region: T5orf172; pfam10544 572477000570 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477000571 PAS domain; Region: PAS_9; pfam13426 572477000572 putative active site [active] 572477000573 heme pocket [chemical binding]; other site 572477000574 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477000575 dimerization interface [polypeptide binding]; other site 572477000576 PAS domain; Region: PAS_9; pfam13426 572477000577 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 572477000578 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477000579 dimer interface [polypeptide binding]; other site 572477000580 putative CheW interface [polypeptide binding]; other site 572477000581 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 572477000582 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 572477000583 active site 572477000584 metal binding site [ion binding]; metal-binding site 572477000585 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 572477000586 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 572477000587 oxaloacetate decarboxylase; Provisional; Region: PRK14040 572477000588 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 572477000589 active site 572477000590 catalytic residues [active] 572477000591 metal binding site [ion binding]; metal-binding site 572477000592 homodimer binding site [polypeptide binding]; other site 572477000593 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 572477000594 carboxyltransferase (CT) interaction site; other site 572477000595 biotinylation site [posttranslational modification]; other site 572477000596 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 572477000597 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 572477000598 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 572477000599 Protein of unknown function (DUF423); Region: DUF423; pfam04241 572477000600 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 572477000601 RNA methyltransferase, RsmE family; Region: TIGR00046 572477000602 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477000603 putative binding surface; other site 572477000604 active site 572477000605 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477000606 putative binding surface; other site 572477000607 active site 572477000608 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477000609 putative binding surface; other site 572477000610 active site 572477000611 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 572477000612 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 572477000613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477000614 ATP binding site [chemical binding]; other site 572477000615 Mg2+ binding site [ion binding]; other site 572477000616 G-X-G motif; other site 572477000617 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 572477000618 Response regulator receiver domain; Region: Response_reg; pfam00072 572477000619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477000620 active site 572477000621 phosphorylation site [posttranslational modification] 572477000622 intermolecular recognition site; other site 572477000623 dimerization interface [polypeptide binding]; other site 572477000624 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572477000625 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477000626 dimer interface [polypeptide binding]; other site 572477000627 putative CheW interface [polypeptide binding]; other site 572477000628 CheW-like domain; Region: CheW; pfam01584 572477000629 Response regulator receiver domain; Region: Response_reg; pfam00072 572477000630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477000631 active site 572477000632 phosphorylation site [posttranslational modification] 572477000633 intermolecular recognition site; other site 572477000634 dimerization interface [polypeptide binding]; other site 572477000635 Response regulator receiver domain; Region: Response_reg; pfam00072 572477000636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477000637 active site 572477000638 phosphorylation site [posttranslational modification] 572477000639 intermolecular recognition site; other site 572477000640 dimerization interface [polypeptide binding]; other site 572477000641 glutathione synthetase; Provisional; Region: PRK05246 572477000642 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 572477000643 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 572477000644 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 572477000645 ApbE family; Region: ApbE; pfam02424 572477000646 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 572477000647 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 572477000648 hypothetical protein; Validated; Region: PRK00228 572477000649 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 572477000650 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572477000651 active site 572477000652 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 572477000653 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 572477000654 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 572477000655 dihydroorotase; Provisional; Region: PRK07627 572477000656 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572477000657 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 572477000658 active site 572477000659 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 572477000660 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 572477000661 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 572477000662 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 572477000663 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 572477000664 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 572477000665 ABC-2 type transporter; Region: ABC2_membrane; cl17235 572477000666 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 572477000667 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 572477000668 Walker A/P-loop; other site 572477000669 ATP binding site [chemical binding]; other site 572477000670 Q-loop/lid; other site 572477000671 ABC transporter signature motif; other site 572477000672 Walker B; other site 572477000673 D-loop; other site 572477000674 H-loop/switch region; other site 572477000675 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 572477000676 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 572477000677 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 572477000678 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572477000679 active site 572477000680 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 572477000681 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 572477000682 Probable Catalytic site; other site 572477000683 metal-binding site 572477000684 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 572477000685 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 572477000686 active site 572477000687 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 572477000688 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 572477000689 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572477000690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572477000691 NAD(P) binding site [chemical binding]; other site 572477000692 active site 572477000693 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572477000694 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 572477000695 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 572477000696 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 572477000697 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 572477000698 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 572477000699 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572477000700 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572477000701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572477000702 NAD(P) binding site [chemical binding]; other site 572477000703 active site 572477000704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 572477000705 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 572477000706 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 572477000707 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 572477000708 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 572477000709 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572477000710 active site 572477000711 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 572477000712 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 572477000713 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 572477000714 Cadherin repeat-like domain; Region: CA_like; cl15786 572477000715 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 572477000716 Cadherin repeat-like domain; Region: CA_like; cl15786 572477000717 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 572477000718 Ca2+ binding site [ion binding]; other site 572477000719 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 572477000720 VCBS repeat; Region: VCBS_repeat; TIGR01965 572477000721 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 572477000722 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 572477000723 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 572477000724 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572477000725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477000726 active site 572477000727 phosphorylation site [posttranslational modification] 572477000728 intermolecular recognition site; other site 572477000729 dimerization interface [polypeptide binding]; other site 572477000730 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572477000731 DNA binding site [nucleotide binding] 572477000732 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 572477000733 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 572477000734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 572477000735 dimer interface [polypeptide binding]; other site 572477000736 phosphorylation site [posttranslational modification] 572477000737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477000738 ATP binding site [chemical binding]; other site 572477000739 Mg2+ binding site [ion binding]; other site 572477000740 G-X-G motif; other site 572477000741 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 572477000742 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572477000743 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 572477000744 Walker A/P-loop; other site 572477000745 ATP binding site [chemical binding]; other site 572477000746 Q-loop/lid; other site 572477000747 ABC transporter signature motif; other site 572477000748 Walker B; other site 572477000749 D-loop; other site 572477000750 H-loop/switch region; other site 572477000751 HlyD family secretion protein; Region: HlyD; pfam00529 572477000752 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 572477000753 HlyD family secretion protein; Region: HlyD_3; pfam13437 572477000754 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 572477000755 active site 572477000756 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 572477000757 homodimer interface [polypeptide binding]; other site 572477000758 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 572477000759 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 572477000760 glutaminase active site [active] 572477000761 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 572477000762 dimer interface [polypeptide binding]; other site 572477000763 active site 572477000764 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 572477000765 dimer interface [polypeptide binding]; other site 572477000766 active site 572477000767 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 572477000768 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 572477000769 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 572477000770 TrkA-N domain; Region: TrkA_N; pfam02254 572477000771 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 572477000772 ABC1 family; Region: ABC1; cl17513 572477000773 PAS fold; Region: PAS_4; pfam08448 572477000774 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477000775 putative active site [active] 572477000776 heme pocket [chemical binding]; other site 572477000777 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477000778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477000779 dimer interface [polypeptide binding]; other site 572477000780 phosphorylation site [posttranslational modification] 572477000781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477000782 ATP binding site [chemical binding]; other site 572477000783 Mg2+ binding site [ion binding]; other site 572477000784 G-X-G motif; other site 572477000785 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477000786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477000787 active site 572477000788 phosphorylation site [posttranslational modification] 572477000789 intermolecular recognition site; other site 572477000790 dimerization interface [polypeptide binding]; other site 572477000791 Response regulator receiver domain; Region: Response_reg; pfam00072 572477000792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477000793 active site 572477000794 phosphorylation site [posttranslational modification] 572477000795 intermolecular recognition site; other site 572477000796 dimerization interface [polypeptide binding]; other site 572477000797 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477000798 putative binding surface; other site 572477000799 active site 572477000800 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 572477000801 active site clefts [active] 572477000802 zinc binding site [ion binding]; other site 572477000803 dimer interface [polypeptide binding]; other site 572477000804 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 572477000805 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 572477000806 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 572477000807 trehalose synthase; Region: treS_nterm; TIGR02456 572477000808 active site 572477000809 catalytic site [active] 572477000810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477000811 Walker A/P-loop; other site 572477000812 ATP binding site [chemical binding]; other site 572477000813 AAA domain; Region: AAA_21; pfam13304 572477000814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 572477000815 ABC transporter signature motif; other site 572477000816 Walker B; other site 572477000817 D-loop; other site 572477000818 H-loop/switch region; other site 572477000819 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 572477000820 putative active site [active] 572477000821 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 572477000822 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 572477000823 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 572477000824 putative substrate binding site [chemical binding]; other site 572477000825 putative ATP binding site [chemical binding]; other site 572477000826 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 572477000827 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 572477000828 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 572477000829 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 572477000830 putative ADP-binding pocket [chemical binding]; other site 572477000831 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 572477000832 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 572477000833 CoenzymeA binding site [chemical binding]; other site 572477000834 subunit interaction site [polypeptide binding]; other site 572477000835 PHB binding site; other site 572477000836 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 572477000837 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 572477000838 putative MPT binding site; other site 572477000839 Flagellar protein FliT; Region: FliT; pfam05400 572477000840 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 572477000841 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 572477000842 HlyD family secretion protein; Region: HlyD_3; pfam13437 572477000843 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 572477000844 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572477000845 active site residue [active] 572477000846 cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which...; Region: cyclophilin_ABH_like; cd01926 572477000847 active site 572477000848 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477000849 putative binding surface; other site 572477000850 active site 572477000851 Response regulator receiver domain; Region: Response_reg; pfam00072 572477000852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477000853 active site 572477000854 phosphorylation site [posttranslational modification] 572477000855 intermolecular recognition site; other site 572477000856 dimerization interface [polypeptide binding]; other site 572477000857 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 572477000858 DNA binding site [nucleotide binding] 572477000859 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 572477000860 active site 572477000861 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 572477000862 DNA binding site [nucleotide binding] 572477000863 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 572477000864 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 572477000865 putative active site [active] 572477000866 putative FMN binding site [chemical binding]; other site 572477000867 putative substrate binding site [chemical binding]; other site 572477000868 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 572477000869 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 572477000870 dimer interface [polypeptide binding]; other site 572477000871 PYR/PP interface [polypeptide binding]; other site 572477000872 TPP binding site [chemical binding]; other site 572477000873 substrate binding site [chemical binding]; other site 572477000874 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 572477000875 Domain of unknown function; Region: EKR; pfam10371 572477000876 4Fe-4S binding domain; Region: Fer4_6; pfam12837 572477000877 4Fe-4S binding domain; Region: Fer4; pfam00037 572477000878 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 572477000879 TPP-binding site [chemical binding]; other site 572477000880 dimer interface [polypeptide binding]; other site 572477000881 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 572477000882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572477000883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572477000884 Coenzyme A binding pocket [chemical binding]; other site 572477000885 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 572477000886 Uncharacterized conserved protein [Function unknown]; Region: COG4715 572477000887 SWIM zinc finger; Region: SWIM; pfam04434 572477000888 anthranilate synthase component I; Provisional; Region: PRK13565 572477000889 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 572477000890 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 572477000891 phosphoglycolate phosphatase; Provisional; Region: PRK13222 572477000892 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572477000893 motif II; other site 572477000894 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 572477000895 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 572477000896 substrate binding site [chemical binding]; other site 572477000897 hexamer interface [polypeptide binding]; other site 572477000898 metal binding site [ion binding]; metal-binding site 572477000899 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 572477000900 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 572477000901 active site 572477000902 catalytic tetrad [active] 572477000903 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 572477000904 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 572477000905 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 572477000906 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 572477000907 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572477000908 active site 572477000909 Pectinacetylesterase; Region: PAE; pfam03283 572477000910 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572477000911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477000912 active site 572477000913 phosphorylation site [posttranslational modification] 572477000914 intermolecular recognition site; other site 572477000915 dimerization interface [polypeptide binding]; other site 572477000916 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572477000917 DNA binding site [nucleotide binding] 572477000918 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477000919 dimerization interface [polypeptide binding]; other site 572477000920 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477000921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477000922 ATP binding site [chemical binding]; other site 572477000923 Mg2+ binding site [ion binding]; other site 572477000924 G-X-G motif; other site 572477000925 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 572477000926 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 572477000927 nucleophile elbow; other site 572477000928 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 572477000929 Surface antigen; Region: Bac_surface_Ag; pfam01103 572477000930 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 572477000931 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 572477000932 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 572477000933 H-NS histone family; Region: Histone_HNS; pfam00816 572477000934 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 572477000935 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 572477000936 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 572477000937 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 572477000938 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 572477000939 protein binding site [polypeptide binding]; other site 572477000940 Biotin operon repressor [Transcription]; Region: BirA; COG1654 572477000941 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 572477000942 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 572477000943 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 572477000944 Type III pantothenate kinase; Region: Pan_kinase; cl17198 572477000945 Uncharacterized conserved protein [Function unknown]; Region: COG1262 572477000946 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 572477000947 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 572477000948 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 572477000949 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 572477000950 catalytic motif [active] 572477000951 Catalytic residue [active] 572477000952 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 572477000953 catalytic motif [active] 572477000954 Catalytic residue [active] 572477000955 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 572477000956 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 572477000957 E3 interaction surface; other site 572477000958 lipoyl attachment site [posttranslational modification]; other site 572477000959 e3 binding domain; Region: E3_binding; pfam02817 572477000960 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 572477000961 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 572477000962 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 572477000963 TPP-binding site [chemical binding]; other site 572477000964 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 572477000965 dimer interface [polypeptide binding]; other site 572477000966 PYR/PP interface [polypeptide binding]; other site 572477000967 TPP binding site [chemical binding]; other site 572477000968 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 572477000969 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 572477000970 domain interfaces; other site 572477000971 active site 572477000972 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 572477000973 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 572477000974 active site 572477000975 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 572477000976 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 572477000977 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572477000978 catalytic loop [active] 572477000979 iron binding site [ion binding]; other site 572477000980 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572477000981 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 572477000982 putative NAD(P) binding site [chemical binding]; other site 572477000983 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 572477000984 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 572477000985 oligopeptidase A; Provisional; Region: PRK10911 572477000986 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 572477000987 active site 572477000988 Zn binding site [ion binding]; other site 572477000989 CNP1-like family; Region: CNP1; pfam08750 572477000990 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 572477000991 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 572477000992 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 572477000993 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 572477000994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 572477000995 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477000996 PAS domain; Region: PAS_9; pfam13426 572477000997 putative active site [active] 572477000998 heme pocket [chemical binding]; other site 572477000999 PAS domain; Region: PAS_9; pfam13426 572477001000 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477001001 putative active site [active] 572477001002 heme pocket [chemical binding]; other site 572477001003 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477001004 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477001005 metal binding site [ion binding]; metal-binding site 572477001006 active site 572477001007 I-site; other site 572477001008 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477001009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477001010 active site 572477001011 phosphorylation site [posttranslational modification] 572477001012 intermolecular recognition site; other site 572477001013 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477001014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477001015 active site 572477001016 phosphorylation site [posttranslational modification] 572477001017 intermolecular recognition site; other site 572477001018 dimerization interface [polypeptide binding]; other site 572477001019 PAS domain; Region: PAS_9; pfam13426 572477001020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477001021 putative active site [active] 572477001022 heme pocket [chemical binding]; other site 572477001023 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477001024 PAS domain; Region: PAS_9; pfam13426 572477001025 putative active site [active] 572477001026 heme pocket [chemical binding]; other site 572477001027 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477001028 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477001029 metal binding site [ion binding]; metal-binding site 572477001030 active site 572477001031 I-site; other site 572477001032 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477001033 Response regulator receiver domain; Region: Response_reg; pfam00072 572477001034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477001035 active site 572477001036 phosphorylation site [posttranslational modification] 572477001037 intermolecular recognition site; other site 572477001038 dimerization interface [polypeptide binding]; other site 572477001039 CHASE domain; Region: CHASE; cl01369 572477001040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477001041 dimer interface [polypeptide binding]; other site 572477001042 phosphorylation site [posttranslational modification] 572477001043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477001044 ATP binding site [chemical binding]; other site 572477001045 G-X-G motif; other site 572477001046 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 572477001047 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 572477001048 intersubunit interface [polypeptide binding]; other site 572477001049 active site 572477001050 zinc binding site [ion binding]; other site 572477001051 Na+ binding site [ion binding]; other site 572477001052 pyruvate kinase; Provisional; Region: PRK05826 572477001053 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 572477001054 domain interfaces; other site 572477001055 active site 572477001056 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 572477001057 Phosphoglycerate kinase; Region: PGK; pfam00162 572477001058 substrate binding site [chemical binding]; other site 572477001059 hinge regions; other site 572477001060 ADP binding site [chemical binding]; other site 572477001061 catalytic site [active] 572477001062 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 572477001063 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 572477001064 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 572477001065 transketolase; Reviewed; Region: PRK12753 572477001066 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 572477001067 TPP-binding site [chemical binding]; other site 572477001068 dimer interface [polypeptide binding]; other site 572477001069 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 572477001070 PYR/PP interface [polypeptide binding]; other site 572477001071 dimer interface [polypeptide binding]; other site 572477001072 TPP binding site [chemical binding]; other site 572477001073 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572477001074 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 572477001075 putative catalytic residue [active] 572477001076 S-adenosylmethionine synthetase; Validated; Region: PRK05250 572477001077 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 572477001078 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 572477001079 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 572477001080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477001081 S-adenosylmethionine binding site [chemical binding]; other site 572477001082 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 572477001083 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 572477001084 homotetramer interface [polypeptide binding]; other site 572477001085 ligand binding site [chemical binding]; other site 572477001086 catalytic site [active] 572477001087 NAD binding site [chemical binding]; other site 572477001088 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 572477001089 FAD binding site [chemical binding]; other site 572477001090 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572477001091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572477001092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572477001093 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 572477001094 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 572477001095 oligomeric interface; other site 572477001096 putative active site [active] 572477001097 homodimer interface [polypeptide binding]; other site 572477001098 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 572477001099 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 572477001100 V-type ATP synthase subunit I; Validated; Region: PRK05771 572477001101 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 572477001102 ApbE family; Region: ApbE; pfam02424 572477001103 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 572477001104 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 572477001105 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 572477001106 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 572477001107 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 572477001108 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 572477001109 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 572477001110 NADH dehydrogenase; Region: NADHdh; cl00469 572477001111 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 572477001112 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572477001113 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 572477001114 transmembrane helices; other site 572477001115 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 572477001116 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 572477001117 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572477001118 PGAP1-like protein; Region: PGAP1; pfam07819 572477001119 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572477001120 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 572477001121 Paraquat-inducible protein A; Region: PqiA; pfam04403 572477001122 Paraquat-inducible protein A; Region: PqiA; pfam04403 572477001123 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 572477001124 mce related protein; Region: MCE; pfam02470 572477001125 mce related protein; Region: MCE; pfam02470 572477001126 mce related protein; Region: MCE; pfam02470 572477001127 Protein of unknown function (DUF330); Region: DUF330; pfam03886 572477001128 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 572477001129 DsrC like protein; Region: DsrC; pfam04358 572477001130 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 572477001131 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 572477001132 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 572477001133 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 572477001134 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 572477001135 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 572477001136 amidase catalytic site [active] 572477001137 Zn binding residues [ion binding]; other site 572477001138 substrate binding site [chemical binding]; other site 572477001139 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 572477001140 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 572477001141 dimerization interface [polypeptide binding]; other site 572477001142 active site 572477001143 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 572477001144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477001145 dimerization interface [polypeptide binding]; other site 572477001146 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477001147 dimer interface [polypeptide binding]; other site 572477001148 putative CheW interface [polypeptide binding]; other site 572477001149 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 572477001150 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 572477001151 HSP70 interaction site [polypeptide binding]; other site 572477001152 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 572477001153 substrate binding site [polypeptide binding]; other site 572477001154 dimer interface [polypeptide binding]; other site 572477001155 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 572477001156 non-specific DNA binding site [nucleotide binding]; other site 572477001157 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 572477001158 salt bridge; other site 572477001159 sequence-specific DNA binding site [nucleotide binding]; other site 572477001160 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 572477001161 2-isopropylmalate synthase; Validated; Region: PRK00915 572477001162 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 572477001163 active site 572477001164 catalytic residues [active] 572477001165 metal binding site [ion binding]; metal-binding site 572477001166 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 572477001167 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 572477001168 Fe-S cluster binding site [ion binding]; other site 572477001169 active site 572477001170 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 572477001171 excinuclease ABC subunit B; Provisional; Region: PRK05298 572477001172 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572477001173 ATP binding site [chemical binding]; other site 572477001174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572477001175 nucleotide binding region [chemical binding]; other site 572477001176 ATP-binding site [chemical binding]; other site 572477001177 Ultra-violet resistance protein B; Region: UvrB; pfam12344 572477001178 UvrB/uvrC motif; Region: UVR; pfam02151 572477001179 aspartate aminotransferase; Provisional; Region: PRK05764 572477001180 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572477001181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477001182 homodimer interface [polypeptide binding]; other site 572477001183 catalytic residue [active] 572477001184 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 572477001185 HAMP domain; Region: HAMP; pfam00672 572477001186 dimerization interface [polypeptide binding]; other site 572477001187 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477001188 dimer interface [polypeptide binding]; other site 572477001189 putative CheW interface [polypeptide binding]; other site 572477001190 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 572477001191 Sensory domain found in PocR; Region: PocR; pfam10114 572477001192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477001193 dimer interface [polypeptide binding]; other site 572477001194 phosphorylation site [posttranslational modification] 572477001195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477001196 ATP binding site [chemical binding]; other site 572477001197 Mg2+ binding site [ion binding]; other site 572477001198 G-X-G motif; other site 572477001199 putative protease; Provisional; Region: PRK15452 572477001200 Peptidase family U32; Region: Peptidase_U32; pfam01136 572477001201 hypothetical protein; Provisional; Region: PRK05170 572477001202 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 572477001203 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 572477001204 DNA binding site [nucleotide binding] 572477001205 active site 572477001206 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 572477001207 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 572477001208 active site 572477001209 Int/Topo IB signature motif; other site 572477001210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 572477001211 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 572477001212 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 572477001213 dimerization domain [polypeptide binding]; other site 572477001214 dimer interface [polypeptide binding]; other site 572477001215 catalytic residues [active] 572477001216 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 572477001217 active site 572477001218 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 572477001219 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572477001220 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 572477001221 putative ADP-binding pocket [chemical binding]; other site 572477001222 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 572477001223 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 572477001224 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 572477001225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572477001226 dimer interface [polypeptide binding]; other site 572477001227 conserved gate region; other site 572477001228 putative PBP binding loops; other site 572477001229 ABC-ATPase subunit interface; other site 572477001230 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 572477001231 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 572477001232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572477001233 dimer interface [polypeptide binding]; other site 572477001234 conserved gate region; other site 572477001235 putative PBP binding loops; other site 572477001236 ABC-ATPase subunit interface; other site 572477001237 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 572477001238 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 572477001239 Walker A/P-loop; other site 572477001240 ATP binding site [chemical binding]; other site 572477001241 Q-loop/lid; other site 572477001242 ABC transporter signature motif; other site 572477001243 Walker B; other site 572477001244 D-loop; other site 572477001245 H-loop/switch region; other site 572477001246 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 572477001247 PhoU domain; Region: PhoU; pfam01895 572477001248 PhoU domain; Region: PhoU; pfam01895 572477001249 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 572477001250 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 572477001251 N-acetyl-D-glucosamine binding site [chemical binding]; other site 572477001252 catalytic residue [active] 572477001253 Methyltransferase domain; Region: Methyltransf_11; pfam08241 572477001254 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 572477001255 RNA/DNA hybrid binding site [nucleotide binding]; other site 572477001256 active site 572477001257 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 572477001258 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 572477001259 active site 572477001260 catalytic site [active] 572477001261 substrate binding site [chemical binding]; other site 572477001262 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 572477001263 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572477001264 ligand binding site [chemical binding]; other site 572477001265 flexible hinge region; other site 572477001266 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 572477001267 putative switch regulator; other site 572477001268 non-specific DNA interactions [nucleotide binding]; other site 572477001269 DNA binding site [nucleotide binding] 572477001270 sequence specific DNA binding site [nucleotide binding]; other site 572477001271 putative cAMP binding site [chemical binding]; other site 572477001272 CTP synthetase; Validated; Region: pyrG; PRK05380 572477001273 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 572477001274 Catalytic site [active] 572477001275 active site 572477001276 UTP binding site [chemical binding]; other site 572477001277 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 572477001278 active site 572477001279 putative oxyanion hole; other site 572477001280 catalytic triad [active] 572477001281 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 572477001282 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 572477001283 enolase; Provisional; Region: eno; PRK00077 572477001284 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 572477001285 dimer interface [polypeptide binding]; other site 572477001286 metal binding site [ion binding]; metal-binding site 572477001287 substrate binding pocket [chemical binding]; other site 572477001288 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 572477001289 Septum formation initiator; Region: DivIC; cl17659 572477001290 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 572477001291 substrate binding site; other site 572477001292 dimer interface; other site 572477001293 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 572477001294 homotrimer interaction site [polypeptide binding]; other site 572477001295 zinc binding site [ion binding]; other site 572477001296 CDP-binding sites; other site 572477001297 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 572477001298 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 572477001299 Permutation of conserved domain; other site 572477001300 active site 572477001301 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 572477001302 Response regulator receiver domain; Region: Response_reg; pfam00072 572477001303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477001304 active site 572477001305 phosphorylation site [posttranslational modification] 572477001306 intermolecular recognition site; other site 572477001307 dimerization interface [polypeptide binding]; other site 572477001308 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 572477001309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 572477001310 ATP binding site [chemical binding]; other site 572477001311 Mg2+ binding site [ion binding]; other site 572477001312 G-X-G motif; other site 572477001313 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 572477001314 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 572477001315 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 572477001316 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 572477001317 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477001318 PAS domain; Region: PAS_9; pfam13426 572477001319 putative active site [active] 572477001320 heme pocket [chemical binding]; other site 572477001321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 572477001322 dimerization interface [polypeptide binding]; other site 572477001323 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572477001324 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477001325 dimer interface [polypeptide binding]; other site 572477001326 putative CheW interface [polypeptide binding]; other site 572477001327 Ion channel; Region: Ion_trans_2; pfam07885 572477001328 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 572477001329 TrkA-N domain; Region: TrkA_N; pfam02254 572477001330 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 572477001331 TrkA-N domain; Region: TrkA_N; pfam02254 572477001332 Hemerythrin family; Region: Hemerythrin-like; cl15774 572477001333 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 572477001334 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 572477001335 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 572477001336 catalytic triad [active] 572477001337 ferrochelatase; Reviewed; Region: hemH; PRK00035 572477001338 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 572477001339 C-terminal domain interface [polypeptide binding]; other site 572477001340 active site 572477001341 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 572477001342 active site 572477001343 N-terminal domain interface [polypeptide binding]; other site 572477001344 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 572477001345 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572477001346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477001347 homodimer interface [polypeptide binding]; other site 572477001348 catalytic residue [active] 572477001349 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 572477001350 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 572477001351 trimer interface [polypeptide binding]; other site 572477001352 active site 572477001353 substrate binding site [chemical binding]; other site 572477001354 CoA binding site [chemical binding]; other site 572477001355 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 572477001356 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 572477001357 metal binding site [ion binding]; metal-binding site 572477001358 dimer interface [polypeptide binding]; other site 572477001359 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 572477001360 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 572477001361 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 572477001362 Switch I; other site 572477001363 Switch II; other site 572477001364 septum formation inhibitor; Reviewed; Region: minC; PRK00339 572477001365 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 572477001366 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 572477001367 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 572477001368 nucleotide binding site/active site [active] 572477001369 HIT family signature motif; other site 572477001370 catalytic residue [active] 572477001371 recombination protein RecR; Reviewed; Region: recR; PRK00076 572477001372 RecR protein; Region: RecR; pfam02132 572477001373 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 572477001374 putative active site [active] 572477001375 putative metal-binding site [ion binding]; other site 572477001376 tetramer interface [polypeptide binding]; other site 572477001377 hypothetical protein; Validated; Region: PRK00153 572477001378 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969 572477001379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477001380 Walker A motif; other site 572477001381 ATP binding site [chemical binding]; other site 572477001382 Walker B motif; other site 572477001383 arginine finger; other site 572477001384 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 572477001385 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 572477001386 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 572477001387 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477001388 dimerization interface [polypeptide binding]; other site 572477001389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477001390 dimer interface [polypeptide binding]; other site 572477001391 phosphorylation site [posttranslational modification] 572477001392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477001393 ATP binding site [chemical binding]; other site 572477001394 Mg2+ binding site [ion binding]; other site 572477001395 G-X-G motif; other site 572477001396 Response regulator receiver domain; Region: Response_reg; pfam00072 572477001397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477001398 active site 572477001399 phosphorylation site [posttranslational modification] 572477001400 intermolecular recognition site; other site 572477001401 dimerization interface [polypeptide binding]; other site 572477001402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477001403 dimer interface [polypeptide binding]; other site 572477001404 phosphorylation site [posttranslational modification] 572477001405 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 572477001406 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477001407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477001408 active site 572477001409 phosphorylation site [posttranslational modification] 572477001410 intermolecular recognition site; other site 572477001411 dimerization interface [polypeptide binding]; other site 572477001412 Response regulator receiver domain; Region: Response_reg; pfam00072 572477001413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477001414 active site 572477001415 phosphorylation site [posttranslational modification] 572477001416 intermolecular recognition site; other site 572477001417 dimerization interface [polypeptide binding]; other site 572477001418 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477001419 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477001420 metal binding site [ion binding]; metal-binding site 572477001421 active site 572477001422 I-site; other site 572477001423 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477001424 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 572477001425 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 572477001426 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 572477001427 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572477001428 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572477001429 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 572477001430 putative dimer interface [polypeptide binding]; other site 572477001431 SnoaL-like domain; Region: SnoaL_3; pfam13474 572477001432 SnoaL-like domain; Region: SnoaL_2; pfam12680 572477001433 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 572477001434 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 572477001435 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477001436 FeS/SAM binding site; other site 572477001437 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 572477001438 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572477001439 putative DNA binding site [nucleotide binding]; other site 572477001440 putative Zn2+ binding site [ion binding]; other site 572477001441 HipA-like N-terminal domain; Region: HipA_N; pfam07805 572477001442 HipA-like C-terminal domain; Region: HipA_C; pfam07804 572477001443 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 572477001444 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 572477001445 GAF domain; Region: GAF; pfam01590 572477001446 Phytochrome region; Region: PHY; pfam00360 572477001447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477001448 dimer interface [polypeptide binding]; other site 572477001449 phosphorylation site [posttranslational modification] 572477001450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477001451 ATP binding site [chemical binding]; other site 572477001452 Mg2+ binding site [ion binding]; other site 572477001453 G-X-G motif; other site 572477001454 Response regulator receiver domain; Region: Response_reg; pfam00072 572477001455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477001456 active site 572477001457 phosphorylation site [posttranslational modification] 572477001458 intermolecular recognition site; other site 572477001459 dimerization interface [polypeptide binding]; other site 572477001460 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 572477001461 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 572477001462 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 572477001463 TPP-binding site; other site 572477001464 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 572477001465 PYR/PP interface [polypeptide binding]; other site 572477001466 dimer interface [polypeptide binding]; other site 572477001467 TPP binding site [chemical binding]; other site 572477001468 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572477001469 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 572477001470 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 572477001471 active site 572477001472 HIGH motif; other site 572477001473 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 572477001474 KMSKS motif; other site 572477001475 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 572477001476 tRNA binding surface [nucleotide binding]; other site 572477001477 anticodon binding site; other site 572477001478 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 572477001479 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 572477001480 oligomerisation interface [polypeptide binding]; other site 572477001481 mobile loop; other site 572477001482 roof hairpin; other site 572477001483 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 572477001484 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 572477001485 ring oligomerisation interface [polypeptide binding]; other site 572477001486 ATP/Mg binding site [chemical binding]; other site 572477001487 stacking interactions; other site 572477001488 hinge regions; other site 572477001489 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 572477001490 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 572477001491 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 572477001492 HIGH motif; other site 572477001493 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 572477001494 active site 572477001495 KMSKS motif; other site 572477001496 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 572477001497 putative active site [active] 572477001498 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 572477001499 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 572477001500 putative metal binding site [ion binding]; other site 572477001501 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 572477001502 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 572477001503 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572477001504 active site 572477001505 HIGH motif; other site 572477001506 nucleotide binding site [chemical binding]; other site 572477001507 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 572477001508 KMSKS motif; other site 572477001509 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 572477001510 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 572477001511 NMT1/THI5 like; Region: NMT1; pfam09084 572477001512 PAS domain S-box; Region: sensory_box; TIGR00229 572477001513 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477001514 putative active site [active] 572477001515 heme pocket [chemical binding]; other site 572477001516 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477001517 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477001518 metal binding site [ion binding]; metal-binding site 572477001519 active site 572477001520 I-site; other site 572477001521 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593 572477001522 ligand binding site [chemical binding]; other site 572477001523 active site 572477001524 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 572477001525 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 572477001526 putative active site [active] 572477001527 Response regulator receiver domain; Region: Response_reg; pfam00072 572477001528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477001529 active site 572477001530 phosphorylation site [posttranslational modification] 572477001531 intermolecular recognition site; other site 572477001532 dimerization interface [polypeptide binding]; other site 572477001533 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 572477001534 Uncharacterized conserved protein [Function unknown]; Region: COG2308 572477001535 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 572477001536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 572477001537 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 572477001538 Predicted transcriptional regulator [Transcription]; Region: COG1959 572477001539 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 572477001540 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 572477001541 putative active site [active] 572477001542 putative PHP Thumb interface [polypeptide binding]; other site 572477001543 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 572477001544 protein-splicing catalytic site; other site 572477001545 thioester formation/cholesterol transfer; other site 572477001546 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 572477001547 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 572477001548 protein-splicing catalytic site; other site 572477001549 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 572477001550 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 572477001551 protein-splicing catalytic site; other site 572477001552 thioester formation/cholesterol transfer; other site 572477001553 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 572477001554 protein-splicing catalytic site; other site 572477001555 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 572477001556 generic binding surface II; other site 572477001557 generic binding surface I; other site 572477001558 hypothetical protein; Provisional; Region: PRK09256 572477001559 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 572477001560 30S subunit binding site; other site 572477001561 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 572477001562 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 572477001563 putative NAD(P) binding site [chemical binding]; other site 572477001564 active site 572477001565 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 572477001566 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 572477001567 MOFRL family; Region: MOFRL; pfam05161 572477001568 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 572477001569 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 572477001570 Glycoprotease family; Region: Peptidase_M22; pfam00814 572477001571 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 572477001572 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 572477001573 substrate binding site [chemical binding]; other site 572477001574 ATP binding site [chemical binding]; other site 572477001575 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 572477001576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477001577 Walker A/P-loop; other site 572477001578 ATP binding site [chemical binding]; other site 572477001579 Q-loop/lid; other site 572477001580 ABC transporter signature motif; other site 572477001581 Walker B; other site 572477001582 D-loop; other site 572477001583 H-loop/switch region; other site 572477001584 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 572477001585 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572477001586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477001587 Walker A/P-loop; other site 572477001588 ATP binding site [chemical binding]; other site 572477001589 Q-loop/lid; other site 572477001590 ABC transporter signature motif; other site 572477001591 Walker B; other site 572477001592 D-loop; other site 572477001593 H-loop/switch region; other site 572477001594 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 572477001595 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 572477001596 dimer interface [polypeptide binding]; other site 572477001597 active site 572477001598 heme binding site [chemical binding]; other site 572477001599 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 572477001600 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 572477001601 PAS domain; Region: PAS; smart00091 572477001602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477001603 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477001604 dimer interface [polypeptide binding]; other site 572477001605 phosphorylation site [posttranslational modification] 572477001606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477001607 ATP binding site [chemical binding]; other site 572477001608 Mg2+ binding site [ion binding]; other site 572477001609 G-X-G motif; other site 572477001610 Response regulator receiver domain; Region: Response_reg; pfam00072 572477001611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477001612 active site 572477001613 phosphorylation site [posttranslational modification] 572477001614 intermolecular recognition site; other site 572477001615 dimerization interface [polypeptide binding]; other site 572477001616 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477001617 putative binding surface; other site 572477001618 active site 572477001619 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 572477001620 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 572477001621 B12 binding site [chemical binding]; other site 572477001622 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 572477001623 UbiA prenyltransferase family; Region: UbiA; pfam01040 572477001624 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572477001625 active site 572477001626 beta-hexosaminidase; Provisional; Region: PRK05337 572477001627 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 572477001628 FtsH Extracellular; Region: FtsH_ext; pfam06480 572477001629 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 572477001630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477001631 Walker A motif; other site 572477001632 ATP binding site [chemical binding]; other site 572477001633 Walker B motif; other site 572477001634 arginine finger; other site 572477001635 Peptidase family M41; Region: Peptidase_M41; pfam01434 572477001636 BolA-like protein; Region: BolA; cl00386 572477001637 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 572477001638 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 572477001639 G1 box; other site 572477001640 putative GEF interaction site [polypeptide binding]; other site 572477001641 GTP/Mg2+ binding site [chemical binding]; other site 572477001642 Switch I region; other site 572477001643 G2 box; other site 572477001644 G3 box; other site 572477001645 Switch II region; other site 572477001646 G4 box; other site 572477001647 G5 box; other site 572477001648 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 572477001649 argininosuccinate lyase; Provisional; Region: PRK00855 572477001650 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 572477001651 active sites [active] 572477001652 tetramer interface [polypeptide binding]; other site 572477001653 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 572477001654 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 572477001655 ATP binding site [chemical binding]; other site 572477001656 substrate interface [chemical binding]; other site 572477001657 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 572477001658 ribosome maturation protein RimP; Reviewed; Region: PRK00092 572477001659 Sm and related proteins; Region: Sm_like; cl00259 572477001660 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 572477001661 putative oligomer interface [polypeptide binding]; other site 572477001662 putative RNA binding site [nucleotide binding]; other site 572477001663 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 572477001664 NusA N-terminal domain; Region: NusA_N; pfam08529 572477001665 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 572477001666 RNA binding site [nucleotide binding]; other site 572477001667 homodimer interface [polypeptide binding]; other site 572477001668 NusA-like KH domain; Region: KH_5; pfam13184 572477001669 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 572477001670 G-X-X-G motif; other site 572477001671 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 572477001672 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 572477001673 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 572477001674 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 572477001675 translation initiation factor IF-2; Region: IF-2; TIGR00487 572477001676 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 572477001677 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 572477001678 G1 box; other site 572477001679 putative GEF interaction site [polypeptide binding]; other site 572477001680 GTP/Mg2+ binding site [chemical binding]; other site 572477001681 Switch I region; other site 572477001682 G2 box; other site 572477001683 G3 box; other site 572477001684 Switch II region; other site 572477001685 G4 box; other site 572477001686 G5 box; other site 572477001687 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 572477001688 Translation-initiation factor 2; Region: IF-2; pfam11987 572477001689 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 572477001690 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 572477001691 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 572477001692 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 572477001693 RNA binding site [nucleotide binding]; other site 572477001694 active site 572477001695 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 572477001696 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 572477001697 16S/18S rRNA binding site [nucleotide binding]; other site 572477001698 S13e-L30e interaction site [polypeptide binding]; other site 572477001699 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 572477001700 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 572477001701 RNase E interface [polypeptide binding]; other site 572477001702 trimer interface [polypeptide binding]; other site 572477001703 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 572477001704 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 572477001705 RNase E interface [polypeptide binding]; other site 572477001706 trimer interface [polypeptide binding]; other site 572477001707 active site 572477001708 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 572477001709 putative nucleic acid binding region [nucleotide binding]; other site 572477001710 G-X-X-G motif; other site 572477001711 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 572477001712 RNA binding site [nucleotide binding]; other site 572477001713 domain interface; other site 572477001714 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 572477001715 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 572477001716 Uncharacterized conserved protein [Function unknown]; Region: COG2308 572477001717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 572477001718 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 572477001719 nickel responsive regulator; Provisional; Region: PRK00630 572477001720 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 572477001721 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 572477001722 Domain of unknown function DUF87; Region: DUF87; pfam01935 572477001723 AAA-like domain; Region: AAA_10; pfam12846 572477001724 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 572477001725 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 572477001726 Walker A/P-loop; other site 572477001727 ATP binding site [chemical binding]; other site 572477001728 Q-loop/lid; other site 572477001729 ABC transporter signature motif; other site 572477001730 Walker B; other site 572477001731 D-loop; other site 572477001732 H-loop/switch region; other site 572477001733 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 572477001734 cobalt transport protein CbiM; Validated; Region: PRK06265 572477001735 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 572477001736 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 572477001737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 572477001738 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 572477001739 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 572477001740 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 572477001741 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 572477001742 AAA domain; Region: AAA_26; pfam13500 572477001743 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 572477001744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477001745 S-adenosylmethionine binding site [chemical binding]; other site 572477001746 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 572477001747 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 572477001748 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 572477001749 substrate-cofactor binding pocket; other site 572477001750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477001751 catalytic residue [active] 572477001752 biotin synthase; Provisional; Region: PRK15108 572477001753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477001754 FeS/SAM binding site; other site 572477001755 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 572477001756 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 572477001757 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572477001758 active site 572477001759 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; pfam10043 572477001760 RHS Repeat; Region: RHS_repeat; pfam05593 572477001761 HEAT repeats; Region: HEAT_2; pfam13646 572477001762 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 572477001763 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 572477001764 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 572477001765 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 572477001766 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 572477001767 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 572477001768 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 572477001769 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 572477001770 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 572477001771 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 572477001772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 572477001773 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 572477001774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477001775 Walker A motif; other site 572477001776 ATP binding site [chemical binding]; other site 572477001777 Walker B motif; other site 572477001778 arginine finger; other site 572477001779 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 572477001780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477001781 Walker A/P-loop; other site 572477001782 ATP binding site [chemical binding]; other site 572477001783 Q-loop/lid; other site 572477001784 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 572477001785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477001786 Walker A/P-loop; other site 572477001787 ATP binding site [chemical binding]; other site 572477001788 Q-loop/lid; other site 572477001789 ABC transporter signature motif; other site 572477001790 Walker B; other site 572477001791 D-loop; other site 572477001792 H-loop/switch region; other site 572477001793 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 572477001794 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 572477001795 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 572477001796 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 572477001797 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 572477001798 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 572477001799 homodimer interface [polypeptide binding]; other site 572477001800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477001801 catalytic residue [active] 572477001802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477001803 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 572477001804 Walker A/P-loop; other site 572477001805 ATP binding site [chemical binding]; other site 572477001806 Q-loop/lid; other site 572477001807 ABC transporter signature motif; other site 572477001808 Walker B; other site 572477001809 D-loop; other site 572477001810 H-loop/switch region; other site 572477001811 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 572477001812 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 572477001813 intersubunit interface [polypeptide binding]; other site 572477001814 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 572477001815 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 572477001816 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 572477001817 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 572477001818 HlyD family secretion protein; Region: HlyD_3; pfam13437 572477001819 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572477001820 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572477001821 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 572477001822 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572477001823 ATP binding site [chemical binding]; other site 572477001824 putative Mg++ binding site [ion binding]; other site 572477001825 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572477001826 nucleotide binding region [chemical binding]; other site 572477001827 ATP-binding site [chemical binding]; other site 572477001828 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 572477001829 HRDC domain; Region: HRDC; pfam00570 572477001830 phosphoribulokinase; Provisional; Region: PRK15453 572477001831 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477001832 dimerization interface [polypeptide binding]; other site 572477001833 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477001834 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477001835 metal binding site [ion binding]; metal-binding site 572477001836 active site 572477001837 I-site; other site 572477001838 electron transport complex RsxE subunit; Provisional; Region: PRK12405 572477001839 FMN-binding domain; Region: FMN_bind; cl01081 572477001840 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 572477001841 putative transporter; Provisional; Region: PRK11660 572477001842 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 572477001843 Sulfate transporter family; Region: Sulfate_transp; pfam00916 572477001844 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 572477001845 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 572477001846 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 572477001847 SLBB domain; Region: SLBB; pfam10531 572477001848 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572477001849 electron transport complex, RnfABCDGE type, B subunit; Region: rnfB; TIGR01944 572477001850 Putative Fe-S cluster; Region: FeS; pfam04060 572477001851 4Fe-4S binding domain; Region: Fer4; pfam00037 572477001852 electron transport complex protein RsxA; Provisional; Region: PRK05151 572477001853 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 572477001854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572477001855 putative substrate translocation pore; other site 572477001856 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 572477001857 Sodium Bile acid symporter family; Region: SBF; cl17470 572477001858 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572477001859 Ligand Binding Site [chemical binding]; other site 572477001860 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572477001861 Ligand Binding Site [chemical binding]; other site 572477001862 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 572477001863 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 572477001864 Sulfate transporter family; Region: Sulfate_transp; pfam00916 572477001865 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 572477001866 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 572477001867 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477001868 FeS/SAM binding site; other site 572477001869 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 572477001870 potassium/proton antiporter; Reviewed; Region: PRK05326 572477001871 TrkA-C domain; Region: TrkA_C; pfam02080 572477001872 Transporter associated domain; Region: CorC_HlyC; smart01091 572477001873 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 572477001874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572477001875 NAD(P) binding site [chemical binding]; other site 572477001876 active site 572477001877 phosphoglycolate phosphatase; Provisional; Region: PRK13222 572477001878 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572477001879 motif II; other site 572477001880 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 572477001881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477001882 S-adenosylmethionine binding site [chemical binding]; other site 572477001883 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 572477001884 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 572477001885 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 572477001886 Na binding site [ion binding]; other site 572477001887 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 572477001888 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 572477001889 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 572477001890 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 572477001891 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 572477001892 HlyD family secretion protein; Region: HlyD_3; pfam13437 572477001893 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 572477001894 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477001895 putative binding surface; other site 572477001896 active site 572477001897 Response regulator receiver domain; Region: Response_reg; pfam00072 572477001898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477001899 active site 572477001900 phosphorylation site [posttranslational modification] 572477001901 intermolecular recognition site; other site 572477001902 dimerization interface [polypeptide binding]; other site 572477001903 Response regulator receiver domain; Region: Response_reg; pfam00072 572477001904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477001905 active site 572477001906 phosphorylation site [posttranslational modification] 572477001907 intermolecular recognition site; other site 572477001908 dimerization interface [polypeptide binding]; other site 572477001909 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477001910 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477001911 metal binding site [ion binding]; metal-binding site 572477001912 active site 572477001913 I-site; other site 572477001914 Response regulator receiver domain; Region: Response_reg; pfam00072 572477001915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477001916 active site 572477001917 phosphorylation site [posttranslational modification] 572477001918 intermolecular recognition site; other site 572477001919 dimerization interface [polypeptide binding]; other site 572477001920 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477001921 putative binding surface; other site 572477001922 active site 572477001923 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 572477001924 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 572477001925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477001926 ATP binding site [chemical binding]; other site 572477001927 Mg2+ binding site [ion binding]; other site 572477001928 G-X-G motif; other site 572477001929 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 572477001930 Response regulator receiver domain; Region: Response_reg; pfam00072 572477001931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477001932 active site 572477001933 phosphorylation site [posttranslational modification] 572477001934 intermolecular recognition site; other site 572477001935 dimerization interface [polypeptide binding]; other site 572477001936 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 572477001937 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 572477001938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477001939 binding surface 572477001940 TPR motif; other site 572477001941 TPR repeat; Region: TPR_11; pfam13414 572477001942 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 572477001943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477001944 active site 572477001945 phosphorylation site [posttranslational modification] 572477001946 intermolecular recognition site; other site 572477001947 dimerization interface [polypeptide binding]; other site 572477001948 CheB methylesterase; Region: CheB_methylest; pfam01339 572477001949 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477001950 dimerization interface [polypeptide binding]; other site 572477001951 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572477001952 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477001953 dimer interface [polypeptide binding]; other site 572477001954 putative CheW interface [polypeptide binding]; other site 572477001955 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 572477001956 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 572477001957 active site 572477001958 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 572477001959 putative binding site; other site 572477001960 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 572477001961 MG2 domain; Region: A2M_N; pfam01835 572477001962 Alpha-2-macroglobulin family; Region: A2M; pfam00207 572477001963 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 572477001964 surface patch; other site 572477001965 thioester region; other site 572477001966 specificity defining residues; other site 572477001967 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 572477001968 Transglycosylase; Region: Transgly; pfam00912 572477001969 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 572477001970 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 572477001971 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 572477001972 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 572477001973 N-terminal plug; other site 572477001974 ligand-binding site [chemical binding]; other site 572477001975 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477001976 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477001977 metal binding site [ion binding]; metal-binding site 572477001978 active site 572477001979 I-site; other site 572477001980 transcription termination factor Rho; Provisional; Region: rho; PRK09376 572477001981 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 572477001982 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 572477001983 RNA binding site [nucleotide binding]; other site 572477001984 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 572477001985 multimer interface [polypeptide binding]; other site 572477001986 Walker A motif; other site 572477001987 ATP binding site [chemical binding]; other site 572477001988 Walker B motif; other site 572477001989 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572477001990 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 572477001991 catalytic residues [active] 572477001992 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 572477001993 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 572477001994 ATP binding site [chemical binding]; other site 572477001995 Mg++ binding site [ion binding]; other site 572477001996 motif III; other site 572477001997 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572477001998 nucleotide binding region [chemical binding]; other site 572477001999 ATP-binding site [chemical binding]; other site 572477002000 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 572477002001 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572477002002 motif II; other site 572477002003 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 572477002004 catalytic residues [active] 572477002005 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 572477002006 phosphate acetyltransferase; Reviewed; Region: PRK05632 572477002007 DRTGG domain; Region: DRTGG; pfam07085 572477002008 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 572477002009 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 572477002010 propionate/acetate kinase; Provisional; Region: PRK12379 572477002011 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 572477002012 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 572477002013 ligand binding site [chemical binding]; other site 572477002014 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 572477002015 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 572477002016 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 572477002017 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 572477002018 Ligand binding site; other site 572477002019 DXD motif; other site 572477002020 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 572477002021 beta-galactosidase; Region: BGL; TIGR03356 572477002022 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 572477002023 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 572477002024 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 572477002025 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 572477002026 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 572477002027 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 572477002028 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 572477002029 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 572477002030 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572477002031 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 572477002032 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 572477002033 metal binding site [ion binding]; metal-binding site 572477002034 substrate binding pocket [chemical binding]; other site 572477002035 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 572477002036 UbiA prenyltransferase family; Region: UbiA; pfam01040 572477002037 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572477002038 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 572477002039 substrate binding site [chemical binding]; other site 572477002040 oxyanion hole (OAH) forming residues; other site 572477002041 trimer interface [polypeptide binding]; other site 572477002042 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 572477002043 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 572477002044 oligomeric interface; other site 572477002045 putative active site [active] 572477002046 homodimer interface [polypeptide binding]; other site 572477002047 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 572477002048 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 572477002049 dimer interface [polypeptide binding]; other site 572477002050 tetramer interface [polypeptide binding]; other site 572477002051 PYR/PP interface [polypeptide binding]; other site 572477002052 TPP binding site [chemical binding]; other site 572477002053 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 572477002054 TPP-binding site [chemical binding]; other site 572477002055 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 572477002056 chorismate binding enzyme; Region: Chorismate_bind; cl10555 572477002057 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572477002058 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 572477002059 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 572477002060 EF-hand domain pair; Region: EF_hand_5; pfam13499 572477002061 Ca2+ binding site [ion binding]; other site 572477002062 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 572477002063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477002064 Walker A/P-loop; other site 572477002065 ATP binding site [chemical binding]; other site 572477002066 Q-loop/lid; other site 572477002067 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572477002068 ABC transporter signature motif; other site 572477002069 Walker B; other site 572477002070 D-loop; other site 572477002071 ABC transporter; Region: ABC_tran_2; pfam12848 572477002072 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572477002073 HDOD domain; Region: HDOD; pfam08668 572477002074 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 572477002075 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572477002076 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 572477002077 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 572477002078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477002079 catalytic residue [active] 572477002080 multifunctional aminopeptidase A; Provisional; Region: PRK00913 572477002081 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 572477002082 interface (dimer of trimers) [polypeptide binding]; other site 572477002083 Substrate-binding/catalytic site; other site 572477002084 Zn-binding sites [ion binding]; other site 572477002085 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 572477002086 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 572477002087 RDD family; Region: RDD; pfam06271 572477002088 PAS domain S-box; Region: sensory_box; TIGR00229 572477002089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477002090 putative active site [active] 572477002091 heme pocket [chemical binding]; other site 572477002092 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 572477002093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477002094 dimer interface [polypeptide binding]; other site 572477002095 phosphorylation site [posttranslational modification] 572477002096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477002097 ATP binding site [chemical binding]; other site 572477002098 Mg2+ binding site [ion binding]; other site 572477002099 G-X-G motif; other site 572477002100 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 572477002101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477002102 active site 572477002103 phosphorylation site [posttranslational modification] 572477002104 intermolecular recognition site; other site 572477002105 dimerization interface [polypeptide binding]; other site 572477002106 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572477002107 DNA binding residues [nucleotide binding] 572477002108 dimerization interface [polypeptide binding]; other site 572477002109 DDE superfamily endonuclease; Region: DDE_5; cl17874 572477002110 RRXRR protein; Region: RRXRR; pfam14239 572477002111 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572477002112 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 572477002113 active site 572477002114 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 572477002115 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 572477002116 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 572477002117 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 572477002118 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 572477002119 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 572477002120 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 572477002121 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 572477002122 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 572477002123 Cascade antiviral complex protein; Validated; Region: PRK09693 572477002124 helicase Cas3; Provisional; Region: PRK09694 572477002125 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 572477002126 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 572477002127 glutamate racemase; Provisional; Region: PRK00865 572477002128 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 572477002129 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 572477002130 FlgN protein; Region: FlgN; pfam05130 572477002131 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 572477002132 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 572477002133 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 572477002134 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 572477002135 Response regulator receiver domain; Region: Response_reg; pfam00072 572477002136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477002137 active site 572477002138 phosphorylation site [posttranslational modification] 572477002139 intermolecular recognition site; other site 572477002140 dimerization interface [polypeptide binding]; other site 572477002141 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 572477002142 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 572477002143 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 572477002144 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 572477002145 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 572477002146 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 572477002147 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 572477002148 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 572477002149 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 572477002150 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 572477002151 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 572477002152 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 572477002153 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 572477002154 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 572477002155 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 572477002156 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 572477002157 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 572477002158 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 572477002159 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 572477002160 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 572477002161 Flagellar L-ring protein; Region: FlgH; pfam02107 572477002162 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 572477002163 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 572477002164 Rod binding protein; Region: Rod-binding; cl01626 572477002165 flagellar rod assembly protein/muramidase FlgJ; Region: flagell_FlgJ; TIGR02541 572477002166 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 572477002167 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 572477002168 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 572477002169 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 572477002170 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 572477002171 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 572477002172 PAS domain; Region: PAS_9; pfam13426 572477002173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477002174 PAS domain; Region: PAS_9; pfam13426 572477002175 putative active site [active] 572477002176 heme pocket [chemical binding]; other site 572477002177 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477002178 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477002179 metal binding site [ion binding]; metal-binding site 572477002180 active site 572477002181 I-site; other site 572477002182 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477002183 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 572477002184 AMP binding site [chemical binding]; other site 572477002185 metal binding site [ion binding]; metal-binding site 572477002186 active site 572477002187 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572477002188 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572477002189 ligand binding site [chemical binding]; other site 572477002190 flexible hinge region; other site 572477002191 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 572477002192 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 572477002193 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 572477002194 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 572477002195 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 572477002196 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 572477002197 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 572477002198 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 572477002199 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 572477002200 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 572477002201 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 572477002202 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 572477002203 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 572477002204 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 572477002205 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 572477002206 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 572477002207 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 572477002208 N-terminal plug; other site 572477002209 ligand-binding site [chemical binding]; other site 572477002210 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 572477002211 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 572477002212 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 572477002213 [2Fe-2S] cluster binding site [ion binding]; other site 572477002214 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 572477002215 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 572477002216 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 572477002217 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 572477002218 putative active site; other site 572477002219 catalytic triad [active] 572477002220 putative dimer interface [polypeptide binding]; other site 572477002221 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 572477002222 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 572477002223 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 572477002224 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 572477002225 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 572477002226 Ligand Binding Site [chemical binding]; other site 572477002227 TilS substrate binding domain; Region: TilS; pfam09179 572477002228 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 572477002229 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 572477002230 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477002231 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477002232 putative active site [active] 572477002233 heme pocket [chemical binding]; other site 572477002234 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477002235 dimer interface [polypeptide binding]; other site 572477002236 phosphorylation site [posttranslational modification] 572477002237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477002238 ATP binding site [chemical binding]; other site 572477002239 Mg2+ binding site [ion binding]; other site 572477002240 G-X-G motif; other site 572477002241 Response regulator receiver domain; Region: Response_reg; pfam00072 572477002242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477002243 active site 572477002244 phosphorylation site [posttranslational modification] 572477002245 intermolecular recognition site; other site 572477002246 dimerization interface [polypeptide binding]; other site 572477002247 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 572477002248 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 572477002249 thioredoxin 2; Provisional; Region: PRK10996 572477002250 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572477002251 catalytic residues [active] 572477002252 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 572477002253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477002254 active site 572477002255 phosphorylation site [posttranslational modification] 572477002256 intermolecular recognition site; other site 572477002257 dimerization interface [polypeptide binding]; other site 572477002258 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572477002259 DNA binding residues [nucleotide binding] 572477002260 dimerization interface [polypeptide binding]; other site 572477002261 PAS fold; Region: PAS; pfam00989 572477002262 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477002263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477002264 dimer interface [polypeptide binding]; other site 572477002265 phosphorylation site [posttranslational modification] 572477002266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477002267 ATP binding site [chemical binding]; other site 572477002268 Mg2+ binding site [ion binding]; other site 572477002269 G-X-G motif; other site 572477002270 Response regulator receiver domain; Region: Response_reg; pfam00072 572477002271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477002272 active site 572477002273 phosphorylation site [posttranslational modification] 572477002274 intermolecular recognition site; other site 572477002275 dimerization interface [polypeptide binding]; other site 572477002276 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 572477002277 tetramer interface [polypeptide binding]; other site 572477002278 dimer interface [polypeptide binding]; other site 572477002279 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 572477002280 tetramer interface [polypeptide binding]; other site 572477002281 dimer interface [polypeptide binding]; other site 572477002282 circadian clock protein KaiC; Reviewed; Region: PRK09302 572477002283 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572477002284 Walker A motif; other site 572477002285 ATP binding site [chemical binding]; other site 572477002286 Walker B motif; other site 572477002287 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572477002288 Walker A motif; other site 572477002289 ATP binding site [chemical binding]; other site 572477002290 Walker B motif; other site 572477002291 Helix-turn-helix domain; Region: HTH_28; pfam13518 572477002292 Winged helix-turn helix; Region: HTH_29; pfam13551 572477002293 PAS fold; Region: PAS_2; pfam08446 572477002294 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 572477002295 GAF domain; Region: GAF; pfam01590 572477002296 Phytochrome region; Region: PHY; pfam00360 572477002297 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477002298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477002299 dimer interface [polypeptide binding]; other site 572477002300 phosphorylation site [posttranslational modification] 572477002301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477002302 ATP binding site [chemical binding]; other site 572477002303 Mg2+ binding site [ion binding]; other site 572477002304 G-X-G motif; other site 572477002305 Response regulator receiver domain; Region: Response_reg; pfam00072 572477002306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477002307 active site 572477002308 phosphorylation site [posttranslational modification] 572477002309 intermolecular recognition site; other site 572477002310 dimerization interface [polypeptide binding]; other site 572477002311 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 572477002312 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 572477002313 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 572477002314 catalytic site [active] 572477002315 subunit interface [polypeptide binding]; other site 572477002316 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 572477002317 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 572477002318 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 572477002319 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 572477002320 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 572477002321 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572477002322 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 572477002323 IMP binding site; other site 572477002324 dimer interface [polypeptide binding]; other site 572477002325 interdomain contacts; other site 572477002326 partial ornithine binding site; other site 572477002327 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 572477002328 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 572477002329 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 572477002330 septum site-determining protein MinD; Region: minD_bact; TIGR01968 572477002331 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 572477002332 Sporulation related domain; Region: SPOR; pfam05036 572477002333 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 572477002334 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572477002335 P-loop; other site 572477002336 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 572477002337 Nucleotide binding site [chemical binding]; other site 572477002338 P loop; other site 572477002339 Magnesium ion binding site [ion binding]; other site 572477002340 DTAP/Switch II; other site 572477002341 Switch I; other site 572477002342 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572477002343 Magnesium ion binding site [ion binding]; other site 572477002344 short chain dehydrogenase; Provisional; Region: PRK05993 572477002345 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 572477002346 NADP binding site [chemical binding]; other site 572477002347 active site 572477002348 steroid binding site; other site 572477002349 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 572477002350 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 572477002351 Protein of unknown function DUF72; Region: DUF72; pfam01904 572477002352 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 572477002353 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 572477002354 dimer interface [polypeptide binding]; other site 572477002355 anticodon binding site; other site 572477002356 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 572477002357 homodimer interface [polypeptide binding]; other site 572477002358 motif 1; other site 572477002359 active site 572477002360 motif 2; other site 572477002361 GAD domain; Region: GAD; pfam02938 572477002362 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 572477002363 motif 3; other site 572477002364 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 572477002365 nudix motif; other site 572477002366 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 572477002367 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572477002368 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 572477002369 Walker A/P-loop; other site 572477002370 ATP binding site [chemical binding]; other site 572477002371 Q-loop/lid; other site 572477002372 ABC transporter signature motif; other site 572477002373 Walker B; other site 572477002374 D-loop; other site 572477002375 H-loop/switch region; other site 572477002376 CHASE domain; Region: CHASE; cl01369 572477002377 PAS fold; Region: PAS_7; pfam12860 572477002378 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477002379 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477002380 putative active site [active] 572477002381 heme pocket [chemical binding]; other site 572477002382 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477002383 dimer interface [polypeptide binding]; other site 572477002384 phosphorylation site [posttranslational modification] 572477002385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477002386 ATP binding site [chemical binding]; other site 572477002387 Mg2+ binding site [ion binding]; other site 572477002388 G-X-G motif; other site 572477002389 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477002390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477002391 active site 572477002392 phosphorylation site [posttranslational modification] 572477002393 intermolecular recognition site; other site 572477002394 dimerization interface [polypeptide binding]; other site 572477002395 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477002396 PAS domain; Region: PAS_9; pfam13426 572477002397 putative active site [active] 572477002398 heme pocket [chemical binding]; other site 572477002399 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 572477002400 GAF domain; Region: GAF_2; pfam13185 572477002401 Response regulator receiver domain; Region: Response_reg; pfam00072 572477002402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477002403 active site 572477002404 phosphorylation site [posttranslational modification] 572477002405 intermolecular recognition site; other site 572477002406 dimerization interface [polypeptide binding]; other site 572477002407 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477002408 putative binding surface; other site 572477002409 active site 572477002410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477002411 Response regulator receiver domain; Region: Response_reg; pfam00072 572477002412 active site 572477002413 phosphorylation site [posttranslational modification] 572477002414 intermolecular recognition site; other site 572477002415 dimerization interface [polypeptide binding]; other site 572477002416 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477002417 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 572477002418 Low molecular weight phosphatase family; Region: LMWPc; cd00115 572477002419 active site 572477002420 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 572477002421 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 572477002422 homodimer interface [polypeptide binding]; other site 572477002423 oligonucleotide binding site [chemical binding]; other site 572477002424 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 572477002425 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572477002426 RNA binding surface [nucleotide binding]; other site 572477002427 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 572477002428 active site 572477002429 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 572477002430 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572477002431 motif II; other site 572477002432 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 572477002433 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 572477002434 tandem repeat interface [polypeptide binding]; other site 572477002435 oligomer interface [polypeptide binding]; other site 572477002436 active site residues [active] 572477002437 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 572477002438 DsrC like protein; Region: DsrC; pfam04358 572477002439 Staphylococcal nuclease homologues; Region: SNc; smart00318 572477002440 Catalytic site; other site 572477002441 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 572477002442 polyphosphate kinase; Provisional; Region: PRK05443 572477002443 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 572477002444 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 572477002445 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 572477002446 putative domain interface [polypeptide binding]; other site 572477002447 putative active site [active] 572477002448 catalytic site [active] 572477002449 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 572477002450 putative domain interface [polypeptide binding]; other site 572477002451 putative active site [active] 572477002452 catalytic site [active] 572477002453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477002454 S-adenosylmethionine binding site [chemical binding]; other site 572477002455 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572477002456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477002457 S-adenosylmethionine binding site [chemical binding]; other site 572477002458 chromosome condensation membrane protein; Provisional; Region: PRK14196 572477002459 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 572477002460 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 572477002461 putative ABC transporter; Region: ycf24; CHL00085 572477002462 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 572477002463 FeS assembly ATPase SufC; Region: sufC; TIGR01978 572477002464 Walker A/P-loop; other site 572477002465 ATP binding site [chemical binding]; other site 572477002466 Q-loop/lid; other site 572477002467 ABC transporter signature motif; other site 572477002468 Walker B; other site 572477002469 D-loop; other site 572477002470 H-loop/switch region; other site 572477002471 FeS assembly protein SufD; Region: sufD; TIGR01981 572477002472 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 572477002473 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 572477002474 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 572477002475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477002476 Walker A motif; other site 572477002477 ATP binding site [chemical binding]; other site 572477002478 Walker B motif; other site 572477002479 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 572477002480 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 572477002481 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 572477002482 putative active site [active] 572477002483 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 572477002484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477002485 active site 572477002486 phosphorylation site [posttranslational modification] 572477002487 intermolecular recognition site; other site 572477002488 dimerization interface [polypeptide binding]; other site 572477002489 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572477002490 DNA binding residues [nucleotide binding] 572477002491 dimerization interface [polypeptide binding]; other site 572477002492 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477002493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477002494 putative active site [active] 572477002495 heme pocket [chemical binding]; other site 572477002496 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477002497 dimer interface [polypeptide binding]; other site 572477002498 phosphorylation site [posttranslational modification] 572477002499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477002500 ATP binding site [chemical binding]; other site 572477002501 Mg2+ binding site [ion binding]; other site 572477002502 G-X-G motif; other site 572477002503 Response regulator receiver domain; Region: Response_reg; pfam00072 572477002504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477002505 active site 572477002506 phosphorylation site [posttranslational modification] 572477002507 intermolecular recognition site; other site 572477002508 dimerization interface [polypeptide binding]; other site 572477002509 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 572477002510 CheB methylesterase; Region: CheB_methylest; pfam01339 572477002511 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 572477002512 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 572477002513 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 572477002514 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 572477002515 PAS domain; Region: PAS_10; pfam13596 572477002516 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 572477002517 Uncharacterized conserved protein [Function unknown]; Region: COG3379 572477002518 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 572477002519 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 572477002520 putative [Fe4-S4] binding site [ion binding]; other site 572477002521 putative molybdopterin cofactor binding site [chemical binding]; other site 572477002522 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 572477002523 putative molybdopterin cofactor binding site; other site 572477002524 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572477002525 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 572477002526 AMMECR1; Region: AMMECR1; pfam01871 572477002527 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 572477002528 putative ligand binding pocket/active site [active] 572477002529 putative metal binding site [ion binding]; other site 572477002530 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 572477002531 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 572477002532 N-acetyl-D-glucosamine binding site [chemical binding]; other site 572477002533 catalytic residue [active] 572477002534 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 572477002535 Phosphate-starvation-inducible E; Region: PsiE; cl01264 572477002536 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572477002537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477002538 S-adenosylmethionine binding site [chemical binding]; other site 572477002539 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 572477002540 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 572477002541 HSP70 interaction site [polypeptide binding]; other site 572477002542 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 572477002543 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1810 572477002544 putative GTP cyclohydrolase; Provisional; Region: PRK13674 572477002545 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 572477002546 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 572477002547 substrate binding pocket [chemical binding]; other site 572477002548 chain length determination region; other site 572477002549 substrate-Mg2+ binding site; other site 572477002550 catalytic residues [active] 572477002551 aspartate-rich region 1; other site 572477002552 active site lid residues [active] 572477002553 aspartate-rich region 2; other site 572477002554 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 572477002555 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 572477002556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477002557 Mg2+ binding site [ion binding]; other site 572477002558 G-X-G motif; other site 572477002559 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 572477002560 anchoring element; other site 572477002561 dimer interface [polypeptide binding]; other site 572477002562 ATP binding site [chemical binding]; other site 572477002563 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 572477002564 active site 572477002565 metal binding site [ion binding]; metal-binding site 572477002566 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 572477002567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572477002568 non-specific DNA binding site [nucleotide binding]; other site 572477002569 salt bridge; other site 572477002570 sequence-specific DNA binding site [nucleotide binding]; other site 572477002571 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 572477002572 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 572477002573 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 572477002574 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 572477002575 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 572477002576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 572477002577 Smr domain; Region: Smr; pfam01713 572477002578 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 572477002579 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 572477002580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477002581 S-adenosylmethionine binding site [chemical binding]; other site 572477002582 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572477002583 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572477002584 Peptidase family M23; Region: Peptidase_M23; pfam01551 572477002585 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 572477002586 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 572477002587 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572477002588 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 572477002589 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572477002590 DNA binding residues [nucleotide binding] 572477002591 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 572477002592 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 572477002593 Low-spin heme binding site [chemical binding]; other site 572477002594 Putative water exit pathway; other site 572477002595 Binuclear center (active site) [active] 572477002596 Putative proton exit pathway; other site 572477002597 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 572477002598 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 572477002599 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 572477002600 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 572477002601 Cytochrome c; Region: Cytochrom_C; pfam00034 572477002602 Cytochrome c; Region: Cytochrom_C; pfam00034 572477002603 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 572477002604 4Fe-4S binding domain; Region: Fer4_5; pfam12801 572477002605 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572477002606 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 572477002607 FixH; Region: FixH; pfam05751 572477002608 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 572477002609 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 572477002610 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 572477002611 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 572477002612 metal-binding site [ion binding] 572477002613 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572477002614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572477002615 motif II; other site 572477002616 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 572477002617 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 572477002618 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477002619 dimerization interface [polypeptide binding]; other site 572477002620 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477002621 dimer interface [polypeptide binding]; other site 572477002622 putative CheW interface [polypeptide binding]; other site 572477002623 PilZ domain; Region: PilZ; pfam07238 572477002624 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 572477002625 NAD synthetase; Provisional; Region: PRK13981 572477002626 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 572477002627 multimer interface [polypeptide binding]; other site 572477002628 active site 572477002629 catalytic triad [active] 572477002630 protein interface 1 [polypeptide binding]; other site 572477002631 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 572477002632 homodimer interface [polypeptide binding]; other site 572477002633 NAD binding pocket [chemical binding]; other site 572477002634 ATP binding pocket [chemical binding]; other site 572477002635 Mg binding site [ion binding]; other site 572477002636 active-site loop [active] 572477002637 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 572477002638 Nitrogen regulatory protein P-II; Region: P-II; smart00938 572477002639 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 572477002640 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 572477002641 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572477002642 RNA binding surface [nucleotide binding]; other site 572477002643 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 572477002644 active site 572477002645 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 572477002646 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 572477002647 ACT domain; Region: ACT_6; pfam13740 572477002648 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 572477002649 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 572477002650 active site 572477002651 catalytic residues [active] 572477002652 metal binding site [ion binding]; metal-binding site 572477002653 C-terminal peptidase (prc); Region: prc; TIGR00225 572477002654 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 572477002655 protein binding site [polypeptide binding]; other site 572477002656 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 572477002657 Catalytic dyad [active] 572477002658 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 572477002659 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 572477002660 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 572477002661 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 572477002662 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 572477002663 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 572477002664 catalytic residues [active] 572477002665 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 572477002666 E3 interaction surface; other site 572477002667 lipoyl attachment site [posttranslational modification]; other site 572477002668 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 572477002669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572477002670 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572477002671 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572477002672 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 572477002673 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 572477002674 E3 interaction surface; other site 572477002675 lipoyl attachment site [posttranslational modification]; other site 572477002676 e3 binding domain; Region: E3_binding; pfam02817 572477002677 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 572477002678 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 572477002679 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 572477002680 dimer interface [polypeptide binding]; other site 572477002681 TPP-binding site [chemical binding]; other site 572477002682 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 572477002683 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 572477002684 hydrogenase maturation protease; Region: hydrog_prot; TIGR00072 572477002685 nickel binding site [ion binding]; other site 572477002686 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 572477002687 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 572477002688 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 572477002689 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 572477002690 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 572477002691 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 572477002692 FAD binding pocket [chemical binding]; other site 572477002693 FAD binding motif [chemical binding]; other site 572477002694 phosphate binding motif [ion binding]; other site 572477002695 beta-alpha-beta structure motif; other site 572477002696 NAD binding pocket [chemical binding]; other site 572477002697 Iron coordination center [ion binding]; other site 572477002698 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 572477002699 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 572477002700 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 572477002701 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 572477002702 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 572477002703 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 572477002704 SurA N-terminal domain; Region: SurA_N; pfam09312 572477002705 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 572477002706 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 572477002707 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 572477002708 OstA-like protein; Region: OstA; cl00844 572477002709 Organic solvent tolerance protein; Region: OstA_C; pfam04453 572477002710 Phosphotransferase enzyme family; Region: APH; pfam01636 572477002711 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 572477002712 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 572477002713 metal ion-dependent adhesion site (MIDAS); other site 572477002714 TIGR03503 family protein; Region: TIGR03503 572477002715 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477002716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477002717 ATP binding site [chemical binding]; other site 572477002718 Mg2+ binding site [ion binding]; other site 572477002719 G-X-G motif; other site 572477002720 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 572477002721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477002722 active site 572477002723 phosphorylation site [posttranslational modification] 572477002724 intermolecular recognition site; other site 572477002725 dimerization interface [polypeptide binding]; other site 572477002726 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477002727 binding surface 572477002728 TPR motif; other site 572477002729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 572477002730 binding surface 572477002731 TPR motif; other site 572477002732 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 572477002733 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 572477002734 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 572477002735 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 572477002736 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 572477002737 acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Region: lipid_A_lpxA; TIGR01852 572477002738 active site 572477002739 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 572477002740 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 572477002741 purine monophosphate binding site [chemical binding]; other site 572477002742 dimer interface [polypeptide binding]; other site 572477002743 putative catalytic residues [active] 572477002744 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 572477002745 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 572477002746 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 572477002747 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 572477002748 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 572477002749 FMN binding site [chemical binding]; other site 572477002750 active site 572477002751 catalytic residues [active] 572477002752 substrate binding site [chemical binding]; other site 572477002753 hypothetical protein; Provisional; Region: PRK10316 572477002754 YfdX protein; Region: YfdX; pfam10938 572477002755 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 572477002756 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 572477002757 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 572477002758 CHAT domain; Region: CHAT; cl17868 572477002759 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 572477002760 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 572477002761 putative active site [active] 572477002762 putative NTP binding site [chemical binding]; other site 572477002763 putative nucleic acid binding site [nucleotide binding]; other site 572477002764 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 572477002765 AAA ATPase domain; Region: AAA_16; pfam13191 572477002766 AAA domain; Region: AAA_22; pfam13401 572477002767 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 572477002768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 572477002769 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 572477002770 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 572477002771 ligand binding site [chemical binding]; other site 572477002772 homodimer interface [polypeptide binding]; other site 572477002773 NAD(P) binding site [chemical binding]; other site 572477002774 trimer interface B [polypeptide binding]; other site 572477002775 trimer interface A [polypeptide binding]; other site 572477002776 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 572477002777 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 572477002778 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 572477002779 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 572477002780 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 572477002781 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 572477002782 Domain of unknown function DUF20; Region: UPF0118; pfam01594 572477002783 phosphoenolpyruvate synthase; Validated; Region: PRK06464 572477002784 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 572477002785 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 572477002786 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 572477002787 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 572477002788 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 572477002789 ligand binding site [chemical binding]; other site 572477002790 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 572477002791 Mechanosensitive ion channel; Region: MS_channel; pfam00924 572477002792 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572477002793 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572477002794 ligand binding site [chemical binding]; other site 572477002795 flexible hinge region; other site 572477002796 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 572477002797 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 572477002798 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 572477002799 trimer interface [polypeptide binding]; other site 572477002800 active site 572477002801 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 572477002802 catalytic site [active] 572477002803 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 572477002804 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572477002805 FtsX-like permease family; Region: FtsX; pfam02687 572477002806 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 572477002807 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572477002808 Walker A/P-loop; other site 572477002809 ATP binding site [chemical binding]; other site 572477002810 Q-loop/lid; other site 572477002811 ABC transporter signature motif; other site 572477002812 Walker B; other site 572477002813 D-loop; other site 572477002814 H-loop/switch region; other site 572477002815 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 572477002816 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 572477002817 ComEC family competence protein; Provisional; Region: PRK11539 572477002818 Competence protein; Region: Competence; pfam03772 572477002819 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 572477002820 cobalamin synthase; Reviewed; Region: cobS; PRK00235 572477002821 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572477002822 catalytic core [active] 572477002823 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 572477002824 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 572477002825 putative dimer interface [polypeptide binding]; other site 572477002826 active site pocket [active] 572477002827 putative cataytic base [active] 572477002828 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 572477002829 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 572477002830 N-terminal plug; other site 572477002831 ligand-binding site [chemical binding]; other site 572477002832 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 572477002833 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 572477002834 ring oligomerisation interface [polypeptide binding]; other site 572477002835 ATP/Mg binding site [chemical binding]; other site 572477002836 stacking interactions; other site 572477002837 hinge regions; other site 572477002838 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 572477002839 oligomerisation interface [polypeptide binding]; other site 572477002840 mobile loop; other site 572477002841 roof hairpin; other site 572477002842 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 572477002843 DHH family; Region: DHH; pfam01368 572477002844 DHHA1 domain; Region: DHHA1; pfam02272 572477002845 Protein of unknown function (DUF615); Region: DUF615; pfam04751 572477002846 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 572477002847 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 572477002848 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477002849 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477002850 I-site; other site 572477002851 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 572477002852 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 572477002853 putative metal binding site [ion binding]; other site 572477002854 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 572477002855 metal ion-dependent adhesion site (MIDAS); other site 572477002856 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 572477002857 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 572477002858 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 572477002859 active site 572477002860 FMN binding site [chemical binding]; other site 572477002861 substrate binding site [chemical binding]; other site 572477002862 homotetramer interface [polypeptide binding]; other site 572477002863 catalytic residue [active] 572477002864 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 572477002865 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 572477002866 active site 572477002867 dimerization interface [polypeptide binding]; other site 572477002868 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 572477002869 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 572477002870 serine O-acetyltransferase; Region: cysE; TIGR01172 572477002871 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 572477002872 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 572477002873 trimer interface [polypeptide binding]; other site 572477002874 active site 572477002875 substrate binding site [chemical binding]; other site 572477002876 CoA binding site [chemical binding]; other site 572477002877 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 572477002878 Rrf2 family protein; Region: rrf2_super; TIGR00738 572477002879 co-chaperone HscB; Provisional; Region: hscB; PRK05014 572477002880 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 572477002881 active site residue [active] 572477002882 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 572477002883 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 572477002884 putative acyl-acceptor binding pocket; other site 572477002885 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572477002886 active site residue [active] 572477002887 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 572477002888 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 572477002889 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477002890 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 572477002891 Walker A/P-loop; other site 572477002892 ATP binding site [chemical binding]; other site 572477002893 Q-loop/lid; other site 572477002894 ABC transporter signature motif; other site 572477002895 Walker B; other site 572477002896 D-loop; other site 572477002897 H-loop/switch region; other site 572477002898 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 572477002899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572477002900 dimer interface [polypeptide binding]; other site 572477002901 conserved gate region; other site 572477002902 putative PBP binding loops; other site 572477002903 ABC-ATPase subunit interface; other site 572477002904 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 572477002905 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 572477002906 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 572477002907 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 572477002908 N-terminal plug; other site 572477002909 ligand-binding site [chemical binding]; other site 572477002910 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 572477002911 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 572477002912 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 572477002913 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 572477002914 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 572477002915 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 572477002916 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 572477002917 Moco binding site; other site 572477002918 metal coordination site [ion binding]; other site 572477002919 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 572477002920 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 572477002921 N-terminal plug; other site 572477002922 ligand-binding site [chemical binding]; other site 572477002923 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 572477002924 active site 572477002925 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477002926 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 572477002927 HAMP domain; Region: HAMP; pfam00672 572477002928 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572477002929 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477002930 dimer interface [polypeptide binding]; other site 572477002931 putative CheW interface [polypeptide binding]; other site 572477002932 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 572477002933 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477002934 Walker A/P-loop; other site 572477002935 ATP binding site [chemical binding]; other site 572477002936 Q-loop/lid; other site 572477002937 ABC transporter signature motif; other site 572477002938 Walker B; other site 572477002939 D-loop; other site 572477002940 H-loop/switch region; other site 572477002941 TOBE domain; Region: TOBE; cl01440 572477002942 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 572477002943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572477002944 dimer interface [polypeptide binding]; other site 572477002945 conserved gate region; other site 572477002946 putative PBP binding loops; other site 572477002947 ABC-ATPase subunit interface; other site 572477002948 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 572477002949 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 572477002950 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 572477002951 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 572477002952 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 572477002953 molybdenum-pterin binding domain; Region: Mop; TIGR00638 572477002954 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 572477002955 catalytic site [active] 572477002956 putative active site [active] 572477002957 putative substrate binding site [chemical binding]; other site 572477002958 dimer interface [polypeptide binding]; other site 572477002959 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 572477002960 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 572477002961 putative active site [active] 572477002962 catalytic triad [active] 572477002963 putative dimer interface [polypeptide binding]; other site 572477002964 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572477002965 active site 572477002966 DNA binding site [nucleotide binding] 572477002967 Int/Topo IB signature motif; other site 572477002968 Helix-turn-helix domain; Region: HTH_17; cl17695 572477002969 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 572477002970 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 572477002971 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 572477002972 ssDNA binding site [nucleotide binding]; other site 572477002973 dimer interface [polypeptide binding]; other site 572477002974 tetramer (dimer of dimers) interface [polypeptide binding]; other site 572477002975 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 572477002976 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 572477002977 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 572477002978 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 572477002979 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 572477002980 probable nitrogen fixation protein; Region: TIGR02935 572477002981 Rop-like; Region: Rop-like; cl02247 572477002982 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 572477002983 heat shock protein HtpX; Provisional; Region: PRK05457 572477002984 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 572477002985 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 572477002986 tetramer interface [polypeptide binding]; other site 572477002987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477002988 catalytic residue [active] 572477002989 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 572477002990 dimer interface [polypeptide binding]; other site 572477002991 catalytic triad [active] 572477002992 peroxidatic and resolving cysteines [active] 572477002993 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 572477002994 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 572477002995 tetramer interface [polypeptide binding]; other site 572477002996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477002997 catalytic residue [active] 572477002998 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 572477002999 lipoyl attachment site [posttranslational modification]; other site 572477003000 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 572477003001 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 572477003002 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 572477003003 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 572477003004 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 572477003005 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 572477003006 HIGH motif; other site 572477003007 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 572477003008 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572477003009 active site 572477003010 KMSKS motif; other site 572477003011 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 572477003012 tRNA binding surface [nucleotide binding]; other site 572477003013 Lipopolysaccharide-assembly; Region: LptE; cl01125 572477003014 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 572477003015 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 572477003016 active site 572477003017 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 572477003018 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 572477003019 Substrate binding site; other site 572477003020 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 572477003021 GTP-binding protein YchF; Reviewed; Region: PRK09601 572477003022 YchF GTPase; Region: YchF; cd01900 572477003023 G1 box; other site 572477003024 GTP/Mg2+ binding site [chemical binding]; other site 572477003025 Switch I region; other site 572477003026 G2 box; other site 572477003027 Switch II region; other site 572477003028 G3 box; other site 572477003029 G4 box; other site 572477003030 G5 box; other site 572477003031 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 572477003032 Fatty acid desaturase; Region: FA_desaturase; pfam00487 572477003033 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 572477003034 putative di-iron ligands [ion binding]; other site 572477003035 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 572477003036 BON domain; Region: BON; pfam04972 572477003037 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 572477003038 Mechanosensitive ion channel; Region: MS_channel; pfam00924 572477003039 PRC-barrel domain; Region: PRC; pfam05239 572477003040 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 572477003041 FOG: CBS domain [General function prediction only]; Region: COG0517 572477003042 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 572477003043 HPP family; Region: HPP; pfam04982 572477003044 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 572477003045 NnrS protein; Region: NnrS; pfam05940 572477003046 CheB methylesterase; Region: CheB_methylest; pfam01339 572477003047 PAS domain S-box; Region: sensory_box; TIGR00229 572477003048 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477003049 putative active site [active] 572477003050 heme pocket [chemical binding]; other site 572477003051 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 572477003052 GAF domain; Region: GAF; pfam01590 572477003053 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 572477003054 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572477003055 Zn2+ binding site [ion binding]; other site 572477003056 Mg2+ binding site [ion binding]; other site 572477003057 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 572477003058 nucleotide binding site [chemical binding]; other site 572477003059 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 572477003060 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 572477003061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477003062 S-adenosylmethionine binding site [chemical binding]; other site 572477003063 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 572477003064 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477003065 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477003066 dimerization interface [polypeptide binding]; other site 572477003067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477003068 dimer interface [polypeptide binding]; other site 572477003069 phosphorylation site [posttranslational modification] 572477003070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477003071 ATP binding site [chemical binding]; other site 572477003072 Mg2+ binding site [ion binding]; other site 572477003073 G-X-G motif; other site 572477003074 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572477003075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477003076 active site 572477003077 phosphorylation site [posttranslational modification] 572477003078 intermolecular recognition site; other site 572477003079 dimerization interface [polypeptide binding]; other site 572477003080 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572477003081 DNA binding site [nucleotide binding] 572477003082 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 572477003083 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 572477003084 HlyD family secretion protein; Region: HlyD_3; pfam13437 572477003085 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 572477003086 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 572477003087 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 572477003088 PYR/PP interface [polypeptide binding]; other site 572477003089 dimer interface [polypeptide binding]; other site 572477003090 TPP binding site [chemical binding]; other site 572477003091 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 572477003092 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 572477003093 TPP-binding site [chemical binding]; other site 572477003094 dimer interface [polypeptide binding]; other site 572477003095 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 572477003096 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 572477003097 putative valine binding site [chemical binding]; other site 572477003098 dimer interface [polypeptide binding]; other site 572477003099 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 572477003100 ketol-acid reductoisomerase; Provisional; Region: PRK05479 572477003101 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 572477003102 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 572477003103 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 572477003104 active site 572477003105 TolQ protein; Region: tolQ; TIGR02796 572477003106 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 572477003107 TolR protein; Region: tolR; TIGR02801 572477003108 TolA protein; Region: tolA_full; TIGR02794 572477003109 TonB C terminal; Region: TonB_2; pfam13103 572477003110 translocation protein TolB; Provisional; Region: tolB; PRK04922 572477003111 TolB amino-terminal domain; Region: TolB_N; pfam04052 572477003112 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 572477003113 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 572477003114 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 572477003115 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 572477003116 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 572477003117 ligand binding site [chemical binding]; other site 572477003118 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 572477003119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477003120 binding surface 572477003121 TPR motif; other site 572477003122 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 572477003123 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572477003124 Zn2+ binding site [ion binding]; other site 572477003125 Mg2+ binding site [ion binding]; other site 572477003126 PAS domain; Region: PAS; smart00091 572477003127 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 572477003128 PAS domain; Region: PAS; smart00091 572477003129 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477003130 PAS domain; Region: PAS_9; pfam13426 572477003131 putative active site [active] 572477003132 heme pocket [chemical binding]; other site 572477003133 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477003134 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477003135 metal binding site [ion binding]; metal-binding site 572477003136 active site 572477003137 I-site; other site 572477003138 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477003139 BolA-like protein; Region: BolA; cl00386 572477003140 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 572477003141 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 572477003142 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 572477003143 Transcriptional regulator [Transcription]; Region: IclR; COG1414 572477003144 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 572477003145 Bacterial transcriptional regulator; Region: IclR; pfam01614 572477003146 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 572477003147 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 572477003148 TPP-binding site [chemical binding]; other site 572477003149 XFP C-terminal domain; Region: XFP_C; pfam09363 572477003150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 572477003151 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572477003152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477003153 Walker A/P-loop; other site 572477003154 ATP binding site [chemical binding]; other site 572477003155 Q-loop/lid; other site 572477003156 ABC transporter signature motif; other site 572477003157 Walker B; other site 572477003158 D-loop; other site 572477003159 H-loop/switch region; other site 572477003160 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 572477003161 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 572477003162 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 572477003163 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 572477003164 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572477003165 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 572477003166 Soluble P-type ATPase [General function prediction only]; Region: COG4087 572477003167 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 572477003168 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 572477003169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477003170 Walker A motif; other site 572477003171 ATP binding site [chemical binding]; other site 572477003172 Walker B motif; other site 572477003173 arginine finger; other site 572477003174 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 572477003175 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477003176 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477003177 metal binding site [ion binding]; metal-binding site 572477003178 active site 572477003179 I-site; other site 572477003180 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 572477003181 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572477003182 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477003183 dimer interface [polypeptide binding]; other site 572477003184 putative CheW interface [polypeptide binding]; other site 572477003185 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 572477003186 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 572477003187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477003188 Response regulator receiver domain; Region: Response_reg; pfam00072 572477003189 active site 572477003190 phosphorylation site [posttranslational modification] 572477003191 intermolecular recognition site; other site 572477003192 dimerization interface [polypeptide binding]; other site 572477003193 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477003194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477003195 active site 572477003196 phosphorylation site [posttranslational modification] 572477003197 intermolecular recognition site; other site 572477003198 dimerization interface [polypeptide binding]; other site 572477003199 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 572477003200 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 572477003201 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 572477003202 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 572477003203 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 572477003204 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 572477003205 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572477003206 Walker A/P-loop; other site 572477003207 ATP binding site [chemical binding]; other site 572477003208 Q-loop/lid; other site 572477003209 ABC transporter signature motif; other site 572477003210 Walker B; other site 572477003211 D-loop; other site 572477003212 H-loop/switch region; other site 572477003213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477003214 dimerization interface [polypeptide binding]; other site 572477003215 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477003216 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477003217 metal binding site [ion binding]; metal-binding site 572477003218 active site 572477003219 I-site; other site 572477003220 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 572477003221 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 572477003222 NADP binding site [chemical binding]; other site 572477003223 dimer interface [polypeptide binding]; other site 572477003224 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 572477003225 Fumarase C-terminus; Region: Fumerase_C; pfam05683 572477003226 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 572477003227 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 572477003228 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 572477003229 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 572477003230 active site 572477003231 dimer interface [polypeptide binding]; other site 572477003232 motif 1; other site 572477003233 motif 2; other site 572477003234 motif 3; other site 572477003235 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 572477003236 anticodon binding site; other site 572477003237 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 572477003238 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 572477003239 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 572477003240 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 572477003241 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 572477003242 23S rRNA binding site [nucleotide binding]; other site 572477003243 L21 binding site [polypeptide binding]; other site 572477003244 L13 binding site [polypeptide binding]; other site 572477003245 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 572477003246 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 572477003247 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 572477003248 dimer interface [polypeptide binding]; other site 572477003249 motif 1; other site 572477003250 active site 572477003251 motif 2; other site 572477003252 motif 3; other site 572477003253 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 572477003254 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 572477003255 putative tRNA-binding site [nucleotide binding]; other site 572477003256 B3/4 domain; Region: B3_4; pfam03483 572477003257 tRNA synthetase B5 domain; Region: B5; smart00874 572477003258 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 572477003259 dimer interface [polypeptide binding]; other site 572477003260 motif 1; other site 572477003261 motif 3; other site 572477003262 motif 2; other site 572477003263 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 572477003264 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 572477003265 IHF dimer interface [polypeptide binding]; other site 572477003266 IHF - DNA interface [nucleotide binding]; other site 572477003267 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 572477003268 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 572477003269 DNA binding residues [nucleotide binding] 572477003270 putative hydrolase; Provisional; Region: PRK10985 572477003271 YebG protein; Region: YebG; cl01217 572477003272 Predicted membrane protein [Function unknown]; Region: COG4682 572477003273 yiaA/B two helix domain; Region: YiaAB; pfam05360 572477003274 yiaA/B two helix domain; Region: YiaAB; pfam05360 572477003275 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 572477003276 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 572477003277 Cupin domain; Region: Cupin_2; pfam07883 572477003278 Predicted periplasmic protein [Function unknown]; Region: COG3904 572477003279 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 572477003280 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 572477003281 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 572477003282 Protein of unknown function (DUF938); Region: DUF938; pfam06080 572477003283 Sodium Bile acid symporter family; Region: SBF; cl17470 572477003284 Domain of unknown function (DUF427); Region: DUF427; pfam04248 572477003285 Transposase; Region: HTH_Tnp_1; cl17663 572477003286 YebG protein; Region: YebG; cl01217 572477003287 peroxiredoxin; Provisional; Region: PRK13189 572477003288 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 572477003289 dimer interface [polypeptide binding]; other site 572477003290 decamer (pentamer of dimers) interface [polypeptide binding]; other site 572477003291 catalytic triad [active] 572477003292 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 572477003293 NADH(P)-binding; Region: NAD_binding_10; pfam13460 572477003294 NAD binding site [chemical binding]; other site 572477003295 substrate binding site [chemical binding]; other site 572477003296 putative active site [active] 572477003297 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572477003298 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 572477003299 dimer interface [polypeptide binding]; other site 572477003300 active site 572477003301 metal binding site [ion binding]; metal-binding site 572477003302 glutathione binding site [chemical binding]; other site 572477003303 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 572477003304 ATP binding site [chemical binding]; other site 572477003305 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 572477003306 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 572477003307 PhnA protein; Region: PhnA; pfam03831 572477003308 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 572477003309 putative deacylase active site [active] 572477003310 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 572477003311 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 572477003312 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 572477003313 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 572477003314 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572477003315 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 572477003316 Walker A/P-loop; other site 572477003317 ATP binding site [chemical binding]; other site 572477003318 Q-loop/lid; other site 572477003319 ABC transporter signature motif; other site 572477003320 Walker B; other site 572477003321 D-loop; other site 572477003322 H-loop/switch region; other site 572477003323 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 572477003324 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 572477003325 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 572477003326 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 572477003327 Ligand binding site; other site 572477003328 oligomer interface; other site 572477003329 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 572477003330 EF-hand domain pair; Region: EF_hand_5; pfam13499 572477003331 Ca2+ binding site [ion binding]; other site 572477003332 short chain dehydrogenase; Provisional; Region: PRK06197 572477003333 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 572477003334 putative NAD(P) binding site [chemical binding]; other site 572477003335 active site 572477003336 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572477003337 RNA binding surface [nucleotide binding]; other site 572477003338 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 572477003339 GSH binding site [chemical binding]; other site 572477003340 catalytic residues [active] 572477003341 aminopeptidase N; Provisional; Region: pepN; PRK14015 572477003342 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 572477003343 active site 572477003344 Zn binding site [ion binding]; other site 572477003345 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 572477003346 Predicted permeases [General function prediction only]; Region: COG0795 572477003347 amidophosphoribosyltransferase; Provisional; Region: PRK09246 572477003348 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 572477003349 active site 572477003350 tetramer interface [polypeptide binding]; other site 572477003351 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572477003352 active site 572477003353 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 572477003354 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 572477003355 homodimer interface [polypeptide binding]; other site 572477003356 substrate-cofactor binding pocket; other site 572477003357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477003358 catalytic residue [active] 572477003359 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 572477003360 metal ion-dependent adhesion site (MIDAS); other site 572477003361 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 572477003362 metal ion-dependent adhesion site (MIDAS); other site 572477003363 Protein phosphatase 2C; Region: PP2C_2; pfam13672 572477003364 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 572477003365 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 572477003366 substrate binding site [chemical binding]; other site 572477003367 activation loop (A-loop); other site 572477003368 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 572477003369 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572477003370 non-specific DNA binding site [nucleotide binding]; other site 572477003371 salt bridge; other site 572477003372 sequence-specific DNA binding site [nucleotide binding]; other site 572477003373 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 572477003374 putative phosphoketolase; Provisional; Region: PRK05261 572477003375 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 572477003376 TPP-binding site; other site 572477003377 Src Homology 3 domain superfamily; Region: SH3; cl17036 572477003378 peptide ligand binding site [polypeptide binding]; other site 572477003379 XFP C-terminal domain; Region: XFP_C; pfam09363 572477003380 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 572477003381 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 572477003382 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 572477003383 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477003384 FeS/SAM binding site; other site 572477003385 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 572477003386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 572477003387 AAA domain; Region: AAA_33; pfam13671 572477003388 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 572477003389 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477003390 EamA-like transporter family; Region: EamA; pfam00892 572477003391 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 572477003392 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 572477003393 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 572477003394 FMN binding site [chemical binding]; other site 572477003395 active site 572477003396 catalytic residues [active] 572477003397 substrate binding site [chemical binding]; other site 572477003398 Sulfatase; Region: Sulfatase; cl17466 572477003399 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 572477003400 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 572477003401 putative ligand binding site [chemical binding]; other site 572477003402 PAS domain S-box; Region: sensory_box; TIGR00229 572477003403 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477003404 putative active site [active] 572477003405 heme pocket [chemical binding]; other site 572477003406 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477003407 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477003408 metal binding site [ion binding]; metal-binding site 572477003409 active site 572477003410 I-site; other site 572477003411 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477003412 Sensors of blue-light using FAD; Region: BLUF; pfam04940 572477003413 Protein of unknown function (DUF3334); Region: DUF3334; pfam11813 572477003414 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 572477003415 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 572477003416 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 572477003417 active site 572477003418 catalytic site [active] 572477003419 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 572477003420 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572477003421 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572477003422 Walker A/P-loop; other site 572477003423 ATP binding site [chemical binding]; other site 572477003424 Q-loop/lid; other site 572477003425 ABC transporter signature motif; other site 572477003426 Walker B; other site 572477003427 D-loop; other site 572477003428 H-loop/switch region; other site 572477003429 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572477003430 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 572477003431 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 572477003432 HlyD family secretion protein; Region: HlyD_3; pfam13437 572477003433 HDOD domain; Region: HDOD; pfam08668 572477003434 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 572477003435 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477003436 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477003437 dimer interface [polypeptide binding]; other site 572477003438 phosphorylation site [posttranslational modification] 572477003439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477003440 ATP binding site [chemical binding]; other site 572477003441 Mg2+ binding site [ion binding]; other site 572477003442 G-X-G motif; other site 572477003443 Response regulator receiver domain; Region: Response_reg; pfam00072 572477003444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477003445 active site 572477003446 phosphorylation site [posttranslational modification] 572477003447 intermolecular recognition site; other site 572477003448 dimerization interface [polypeptide binding]; other site 572477003449 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 572477003450 putative binding surface; other site 572477003451 active site 572477003452 RRXRR protein; Region: RRXRR; pfam14239 572477003453 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572477003454 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 572477003455 active site 572477003456 PAS domain; Region: PAS; smart00091 572477003457 PAS domain; Region: PAS_9; pfam13426 572477003458 PAS domain S-box; Region: sensory_box; TIGR00229 572477003459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477003460 putative active site [active] 572477003461 heme pocket [chemical binding]; other site 572477003462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477003463 PAS domain; Region: PAS_9; pfam13426 572477003464 putative active site [active] 572477003465 heme pocket [chemical binding]; other site 572477003466 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477003467 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477003468 putative active site [active] 572477003469 heme pocket [chemical binding]; other site 572477003470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477003471 dimer interface [polypeptide binding]; other site 572477003472 phosphorylation site [posttranslational modification] 572477003473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477003474 ATP binding site [chemical binding]; other site 572477003475 Mg2+ binding site [ion binding]; other site 572477003476 G-X-G motif; other site 572477003477 Response regulator receiver domain; Region: Response_reg; pfam00072 572477003478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477003479 active site 572477003480 phosphorylation site [posttranslational modification] 572477003481 intermolecular recognition site; other site 572477003482 dimerization interface [polypeptide binding]; other site 572477003483 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477003484 putative binding surface; other site 572477003485 active site 572477003486 GAF domain; Region: GAF_3; pfam13492 572477003487 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 572477003488 Histidine kinase; Region: HisKA_3; pfam07730 572477003489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477003490 ATP binding site [chemical binding]; other site 572477003491 Mg2+ binding site [ion binding]; other site 572477003492 G-X-G motif; other site 572477003493 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572477003494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477003495 active site 572477003496 phosphorylation site [posttranslational modification] 572477003497 intermolecular recognition site; other site 572477003498 dimerization interface [polypeptide binding]; other site 572477003499 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572477003500 DNA binding residues [nucleotide binding] 572477003501 dimerization interface [polypeptide binding]; other site 572477003502 epoxyqueuosine reductase; Region: TIGR00276 572477003503 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 572477003504 4Fe-4S binding domain; Region: Fer4; pfam00037 572477003505 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572477003506 Ligand Binding Site [chemical binding]; other site 572477003507 DctM-like transporters; Region: DctM; pfam06808 572477003508 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 572477003509 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 572477003510 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 572477003511 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 572477003512 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 572477003513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477003514 FeS/SAM binding site; other site 572477003515 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 572477003516 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 572477003517 Peptidase family U32; Region: Peptidase_U32; pfam01136 572477003518 putative protease; Provisional; Region: PRK15447 572477003519 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 572477003520 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 572477003521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477003522 dimer interface [polypeptide binding]; other site 572477003523 phosphorylation site [posttranslational modification] 572477003524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477003525 ATP binding site [chemical binding]; other site 572477003526 G-X-G motif; other site 572477003527 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 572477003528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477003529 active site 572477003530 phosphorylation site [posttranslational modification] 572477003531 intermolecular recognition site; other site 572477003532 dimerization interface [polypeptide binding]; other site 572477003533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477003534 Walker A motif; other site 572477003535 ATP binding site [chemical binding]; other site 572477003536 Walker B motif; other site 572477003537 arginine finger; other site 572477003538 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 572477003539 Cache domain; Region: Cache_1; pfam02743 572477003540 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 572477003541 HAMP domain; Region: HAMP; pfam00672 572477003542 dimerization interface [polypeptide binding]; other site 572477003543 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477003544 dimer interface [polypeptide binding]; other site 572477003545 putative CheW interface [polypeptide binding]; other site 572477003546 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 572477003547 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572477003548 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572477003549 substrate binding pocket [chemical binding]; other site 572477003550 membrane-bound complex binding site; other site 572477003551 hinge residues; other site 572477003552 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572477003553 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572477003554 substrate binding pocket [chemical binding]; other site 572477003555 membrane-bound complex binding site; other site 572477003556 hinge residues; other site 572477003557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477003558 dimer interface [polypeptide binding]; other site 572477003559 phosphorylation site [posttranslational modification] 572477003560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477003561 ATP binding site [chemical binding]; other site 572477003562 Mg2+ binding site [ion binding]; other site 572477003563 G-X-G motif; other site 572477003564 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477003565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477003566 active site 572477003567 phosphorylation site [posttranslational modification] 572477003568 intermolecular recognition site; other site 572477003569 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 572477003570 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477003571 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477003572 metal binding site [ion binding]; metal-binding site 572477003573 active site 572477003574 I-site; other site 572477003575 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477003576 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 572477003577 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 572477003578 FAD binding domain; Region: FAD_binding_4; pfam01565 572477003579 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 572477003580 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 572477003581 Cysteine-rich domain; Region: CCG; pfam02754 572477003582 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 572477003583 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 572477003584 sugar binding site [chemical binding]; other site 572477003585 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 572477003586 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 572477003587 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 572477003588 Precorrin-8X methylmutase; Region: CbiC; pfam02570 572477003589 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 572477003590 active site 572477003591 SAM binding site [chemical binding]; other site 572477003592 homodimer interface [polypeptide binding]; other site 572477003593 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 572477003594 active site 572477003595 SAM binding site [chemical binding]; other site 572477003596 homodimer interface [polypeptide binding]; other site 572477003597 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 572477003598 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 572477003599 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 572477003600 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 572477003601 PAS domain S-box; Region: sensory_box; TIGR00229 572477003602 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477003603 putative active site [active] 572477003604 heme pocket [chemical binding]; other site 572477003605 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 572477003606 GAF domain; Region: GAF; pfam01590 572477003607 PAS domain S-box; Region: sensory_box; TIGR00229 572477003608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477003609 putative active site [active] 572477003610 heme pocket [chemical binding]; other site 572477003611 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477003612 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477003613 metal binding site [ion binding]; metal-binding site 572477003614 active site 572477003615 I-site; other site 572477003616 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477003617 CitB domain protein; Region: CitB; TIGR02484 572477003618 tricarballylate dehydrogenase; Validated; Region: PRK08274 572477003619 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 572477003620 active site 572477003621 SAM binding site [chemical binding]; other site 572477003622 homodimer interface [polypeptide binding]; other site 572477003623 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 572477003624 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 572477003625 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 572477003626 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 572477003627 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572477003628 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572477003629 aromatic acid decarboxylase; Validated; Region: PRK05920 572477003630 Flavoprotein; Region: Flavoprotein; pfam02441 572477003631 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 572477003632 Helicase; Region: Helicase_RecD; pfam05127 572477003633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572477003634 Coenzyme A binding pocket [chemical binding]; other site 572477003635 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 572477003636 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 572477003637 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 572477003638 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 572477003639 Cytochrome c; Region: Cytochrom_C; cl11414 572477003640 Cytochrome c; Region: Cytochrom_C; cl11414 572477003641 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 572477003642 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 572477003643 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 572477003644 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 572477003645 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 572477003646 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 572477003647 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 572477003648 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 572477003649 quinolinate synthetase; Provisional; Region: PRK09375 572477003650 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 572477003651 Dynamin family; Region: Dynamin_N; pfam00350 572477003652 G1 box; other site 572477003653 GTP/Mg2+ binding site [chemical binding]; other site 572477003654 G2 box; other site 572477003655 Switch I region; other site 572477003656 G3 box; other site 572477003657 Switch II region; other site 572477003658 G4 box; other site 572477003659 recombinase A; Provisional; Region: recA; PRK09354 572477003660 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 572477003661 hexamer interface [polypeptide binding]; other site 572477003662 Walker A motif; other site 572477003663 ATP binding site [chemical binding]; other site 572477003664 Walker B motif; other site 572477003665 recombination regulator RecX; Reviewed; Region: recX; PRK00117 572477003666 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 572477003667 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 572477003668 motif 1; other site 572477003669 active site 572477003670 motif 2; other site 572477003671 motif 3; other site 572477003672 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 572477003673 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 572477003674 DHHA1 domain; Region: DHHA1; pfam02272 572477003675 aspartate kinase; Reviewed; Region: PRK06635 572477003676 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 572477003677 putative nucleotide binding site [chemical binding]; other site 572477003678 putative catalytic residues [active] 572477003679 putative Mg ion binding site [ion binding]; other site 572477003680 putative aspartate binding site [chemical binding]; other site 572477003681 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 572477003682 putative allosteric regulatory site; other site 572477003683 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 572477003684 carbon storage regulator; Provisional; Region: PRK01712 572477003685 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 572477003686 MutS domain I; Region: MutS_I; pfam01624 572477003687 MutS domain II; Region: MutS_II; pfam05188 572477003688 MutS domain III; Region: MutS_III; pfam05192 572477003689 MutS domain V; Region: MutS_V; pfam00488 572477003690 Walker A/P-loop; other site 572477003691 ATP binding site [chemical binding]; other site 572477003692 Q-loop/lid; other site 572477003693 ABC transporter signature motif; other site 572477003694 Walker B; other site 572477003695 D-loop; other site 572477003696 H-loop/switch region; other site 572477003697 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 572477003698 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 572477003699 ligand binding site [chemical binding]; other site 572477003700 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 572477003701 hypothetical protein; Provisional; Region: PRK10621 572477003702 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 572477003703 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572477003704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477003705 Walker A/P-loop; other site 572477003706 ATP binding site [chemical binding]; other site 572477003707 Q-loop/lid; other site 572477003708 ABC transporter signature motif; other site 572477003709 Walker B; other site 572477003710 D-loop; other site 572477003711 H-loop/switch region; other site 572477003712 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 572477003713 inner membrane transport permease; Provisional; Region: PRK15066 572477003714 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 572477003715 Transglycosylase; Region: Transgly; pfam00912 572477003716 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 572477003717 TPR repeat; Region: TPR_11; pfam13414 572477003718 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477003719 binding surface 572477003720 TPR motif; other site 572477003721 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 572477003722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477003723 S-adenosylmethionine binding site [chemical binding]; other site 572477003724 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 572477003725 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 572477003726 ATP sulphurylase; Region: sopT; TIGR00339 572477003727 ATP-sulfurylase; Region: ATPS; cd00517 572477003728 active site 572477003729 HXXH motif; other site 572477003730 flexible loop; other site 572477003731 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 572477003732 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 572477003733 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 572477003734 adenosine phosphosulphate reductase, alpha subunit; Region: aprA; TIGR02061 572477003735 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 572477003736 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 572477003737 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 572477003738 active site 572477003739 metal binding site [ion binding]; metal-binding site 572477003740 homotetramer interface [polypeptide binding]; other site 572477003741 shikimate kinase; Reviewed; Region: aroK; PRK00131 572477003742 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 572477003743 ligand-binding site [chemical binding]; other site 572477003744 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 572477003745 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 572477003746 DEAD_2; Region: DEAD_2; pfam06733 572477003747 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 572477003748 HDOD domain; Region: HDOD; pfam08668 572477003749 DnaJ chaperone protein; Provisional; Region: PTZ00100 572477003750 DNA repair protein RadA; Provisional; Region: PRK11823 572477003751 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572477003752 Walker A motif; other site 572477003753 ATP binding site [chemical binding]; other site 572477003754 Walker B motif; other site 572477003755 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 572477003756 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 572477003757 active site 572477003758 substrate binding pocket [chemical binding]; other site 572477003759 dimer interface [polypeptide binding]; other site 572477003760 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 572477003761 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 572477003762 active site 572477003763 substrate-binding site [chemical binding]; other site 572477003764 metal-binding site [ion binding] 572477003765 ATP binding site [chemical binding]; other site 572477003766 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 572477003767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572477003768 dimer interface [polypeptide binding]; other site 572477003769 conserved gate region; other site 572477003770 putative PBP binding loops; other site 572477003771 ABC-ATPase subunit interface; other site 572477003772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572477003773 dimer interface [polypeptide binding]; other site 572477003774 conserved gate region; other site 572477003775 putative PBP binding loops; other site 572477003776 ABC-ATPase subunit interface; other site 572477003777 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 572477003778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477003779 Walker A/P-loop; other site 572477003780 ATP binding site [chemical binding]; other site 572477003781 Q-loop/lid; other site 572477003782 ABC transporter signature motif; other site 572477003783 Walker B; other site 572477003784 D-loop; other site 572477003785 H-loop/switch region; other site 572477003786 TOBE domain; Region: TOBE_2; pfam08402 572477003787 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 572477003788 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 572477003789 imidazole glycerol phosphate synthase hisHF; Region: PLN02617 572477003790 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 572477003791 putative active site [active] 572477003792 oxyanion strand; other site 572477003793 catalytic triad [active] 572477003794 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 572477003795 substrate binding site [chemical binding]; other site 572477003796 glutamase interaction surface [polypeptide binding]; other site 572477003797 Predicted periplasmic protein [Function unknown]; Region: COG3904 572477003798 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 572477003799 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 572477003800 Probable transposase; Region: OrfB_IS605; pfam01385 572477003801 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 572477003802 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 572477003803 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 572477003804 Capsid triplex subunit 2; Provisional; Region: PHA03258 572477003805 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 572477003806 PAS domain S-box; Region: sensory_box; TIGR00229 572477003807 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477003808 putative active site [active] 572477003809 heme pocket [chemical binding]; other site 572477003810 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477003811 PAS fold; Region: PAS_3; pfam08447 572477003812 putative active site [active] 572477003813 heme pocket [chemical binding]; other site 572477003814 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477003815 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477003816 metal binding site [ion binding]; metal-binding site 572477003817 active site 572477003818 I-site; other site 572477003819 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572477003820 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 572477003821 ligand binding site [chemical binding]; other site 572477003822 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 572477003823 non-specific DNA interactions [nucleotide binding]; other site 572477003824 DNA binding site [nucleotide binding] 572477003825 sequence specific DNA binding site [nucleotide binding]; other site 572477003826 putative cAMP binding site [chemical binding]; other site 572477003827 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572477003828 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 572477003829 ligand binding site [chemical binding]; other site 572477003830 flexible hinge region; other site 572477003831 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 572477003832 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 572477003833 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572477003834 Putative glucoamylase; Region: Glycoamylase; pfam10091 572477003835 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 572477003836 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 572477003837 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 572477003838 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 572477003839 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 572477003840 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 572477003841 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572477003842 Soluble P-type ATPase [General function prediction only]; Region: COG4087 572477003843 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 572477003844 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 572477003845 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 572477003846 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 572477003847 Ligand Binding Site [chemical binding]; other site 572477003848 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 572477003849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477003850 dimer interface [polypeptide binding]; other site 572477003851 phosphorylation site [posttranslational modification] 572477003852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477003853 ATP binding site [chemical binding]; other site 572477003854 Mg2+ binding site [ion binding]; other site 572477003855 G-X-G motif; other site 572477003856 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 572477003857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477003858 active site 572477003859 phosphorylation site [posttranslational modification] 572477003860 intermolecular recognition site; other site 572477003861 dimerization interface [polypeptide binding]; other site 572477003862 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572477003863 DNA binding site [nucleotide binding] 572477003864 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 572477003865 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 572477003866 Predicted membrane protein [Function unknown]; Region: COG4325 572477003867 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 572477003868 CheB methylesterase; Region: CheB_methylest; pfam01339 572477003869 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 572477003870 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 572477003871 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 572477003872 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 572477003873 PAS domain; Region: PAS_10; pfam13596 572477003874 PAS fold; Region: PAS; pfam00989 572477003875 PAS domain S-box; Region: sensory_box; TIGR00229 572477003876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477003877 putative active site [active] 572477003878 heme pocket [chemical binding]; other site 572477003879 PAS fold; Region: PAS_3; pfam08447 572477003880 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 572477003881 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477003882 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477003883 metal binding site [ion binding]; metal-binding site 572477003884 active site 572477003885 I-site; other site 572477003886 ferredoxin; Validated; Region: PRK07118 572477003887 Putative Fe-S cluster; Region: FeS; cl17515 572477003888 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572477003889 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674 572477003890 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 572477003891 dimer interface [polypeptide binding]; other site 572477003892 PYR/PP interface [polypeptide binding]; other site 572477003893 TPP binding site [chemical binding]; other site 572477003894 substrate binding site [chemical binding]; other site 572477003895 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 572477003896 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 572477003897 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 572477003898 TPP-binding site [chemical binding]; other site 572477003899 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 572477003900 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 572477003901 SLBB domain; Region: SLBB; pfam10531 572477003902 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572477003903 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 572477003904 FMN-binding domain; Region: FMN_bind; cl01081 572477003905 electron transport complex RsxE subunit; Provisional; Region: PRK12405 572477003906 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 572477003907 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 572477003908 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 572477003909 FAD binding pocket [chemical binding]; other site 572477003910 conserved FAD binding motif [chemical binding]; other site 572477003911 phosphate binding motif [ion binding]; other site 572477003912 beta-alpha-beta structure motif; other site 572477003913 NAD binding pocket [chemical binding]; other site 572477003914 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 572477003915 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 572477003916 active site 572477003917 Riboflavin kinase; Region: Flavokinase; smart00904 572477003918 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 572477003919 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 572477003920 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 572477003921 magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407 572477003922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477003923 Walker A motif; other site 572477003924 ATP binding site [chemical binding]; other site 572477003925 Walker B motif; other site 572477003926 arginine finger; other site 572477003927 magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406 572477003928 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 572477003929 metal ion-dependent adhesion site (MIDAS); other site 572477003930 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 572477003931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477003932 active site 572477003933 phosphorylation site [posttranslational modification] 572477003934 intermolecular recognition site; other site 572477003935 dimerization interface [polypeptide binding]; other site 572477003936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477003937 Walker A motif; other site 572477003938 ATP binding site [chemical binding]; other site 572477003939 Walker B motif; other site 572477003940 arginine finger; other site 572477003941 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 572477003942 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 572477003943 oligomeric interface; other site 572477003944 putative active site [active] 572477003945 homodimer interface [polypeptide binding]; other site 572477003946 Helix-turn-helix domain; Region: HTH_17; pfam12728 572477003947 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 572477003948 Sel1-like repeats; Region: SEL1; smart00671 572477003949 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 572477003950 Pilin (bacterial filament); Region: Pilin; pfam00114 572477003951 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 572477003952 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 572477003953 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 572477003954 FtsX-like permease family; Region: FtsX; pfam02687 572477003955 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 572477003956 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572477003957 Walker A/P-loop; other site 572477003958 ATP binding site [chemical binding]; other site 572477003959 Q-loop/lid; other site 572477003960 ABC transporter signature motif; other site 572477003961 Walker B; other site 572477003962 D-loop; other site 572477003963 H-loop/switch region; other site 572477003964 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 572477003965 active site 572477003966 catalytic triad [active] 572477003967 oxyanion hole [active] 572477003968 switch loop; other site 572477003969 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 572477003970 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 572477003971 Protein export membrane protein; Region: SecD_SecF; pfam02355 572477003972 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 572477003973 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 572477003974 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 572477003975 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 572477003976 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 572477003977 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 572477003978 active site 572477003979 HIGH motif; other site 572477003980 KMSKS motif; other site 572477003981 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 572477003982 tRNA binding surface [nucleotide binding]; other site 572477003983 anticodon binding site; other site 572477003984 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 572477003985 dimer interface [polypeptide binding]; other site 572477003986 putative tRNA-binding site [nucleotide binding]; other site 572477003987 antiporter inner membrane protein; Provisional; Region: PRK11670 572477003988 Domain of unknown function DUF59; Region: DUF59; pfam01883 572477003989 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 572477003990 Walker A motif; other site 572477003991 molybdenum transport protein ModD; Provisional; Region: PRK06096 572477003992 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 572477003993 dimerization interface [polypeptide binding]; other site 572477003994 active site 572477003995 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 572477003996 Ferritin-like domain; Region: Ferritin; pfam00210 572477003997 ferroxidase diiron center [ion binding]; other site 572477003998 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 572477003999 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477004000 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477004001 metal binding site [ion binding]; metal-binding site 572477004002 active site 572477004003 I-site; other site 572477004004 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572477004005 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 572477004006 substrate binding pocket [chemical binding]; other site 572477004007 membrane-bound complex binding site; other site 572477004008 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 572477004009 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 572477004010 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 572477004011 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 572477004012 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 572477004013 active site 572477004014 NTP binding site [chemical binding]; other site 572477004015 metal binding triad [ion binding]; metal-binding site 572477004016 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 572477004017 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572477004018 Zn2+ binding site [ion binding]; other site 572477004019 Mg2+ binding site [ion binding]; other site 572477004020 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 572477004021 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 572477004022 CAP-like domain; other site 572477004023 active site 572477004024 primary dimer interface [polypeptide binding]; other site 572477004025 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 572477004026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477004027 active site 572477004028 phosphorylation site [posttranslational modification] 572477004029 intermolecular recognition site; other site 572477004030 dimerization interface [polypeptide binding]; other site 572477004031 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572477004032 Zn2+ binding site [ion binding]; other site 572477004033 Mg2+ binding site [ion binding]; other site 572477004034 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 572477004035 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 572477004036 active site 1 [active] 572477004037 dimer interface [polypeptide binding]; other site 572477004038 active site 2 [active] 572477004039 prolyl-tRNA synthetase; Provisional; Region: PRK09194 572477004040 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 572477004041 dimer interface [polypeptide binding]; other site 572477004042 motif 1; other site 572477004043 active site 572477004044 motif 2; other site 572477004045 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 572477004046 putative deacylase active site [active] 572477004047 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 572477004048 active site 572477004049 motif 3; other site 572477004050 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 572477004051 anticodon binding site; other site 572477004052 PilZ domain; Region: PilZ; pfam07238 572477004053 putative carbohydrate kinase; Provisional; Region: PRK10565 572477004054 Uncharacterized conserved protein [Function unknown]; Region: COG0062 572477004055 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 572477004056 putative substrate binding site [chemical binding]; other site 572477004057 putative ATP binding site [chemical binding]; other site 572477004058 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 572477004059 AMIN domain; Region: AMIN; pfam11741 572477004060 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 572477004061 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 572477004062 active site 572477004063 metal binding site [ion binding]; metal-binding site 572477004064 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572477004065 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 572477004066 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 572477004067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477004068 ATP binding site [chemical binding]; other site 572477004069 Mg2+ binding site [ion binding]; other site 572477004070 G-X-G motif; other site 572477004071 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 572477004072 ATP binding site [chemical binding]; other site 572477004073 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 572477004074 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 572477004075 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 572477004076 active site 572477004077 bacterial Hfq-like; Region: Hfq; cd01716 572477004078 hexamer interface [polypeptide binding]; other site 572477004079 Sm1 motif; other site 572477004080 RNA binding site [nucleotide binding]; other site 572477004081 Sm2 motif; other site 572477004082 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 572477004083 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 572477004084 HflX GTPase family; Region: HflX; cd01878 572477004085 G1 box; other site 572477004086 GTP/Mg2+ binding site [chemical binding]; other site 572477004087 Switch I region; other site 572477004088 G2 box; other site 572477004089 G3 box; other site 572477004090 Switch II region; other site 572477004091 G4 box; other site 572477004092 G5 box; other site 572477004093 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 572477004094 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 572477004095 HflK protein; Region: hflK; TIGR01933 572477004096 HflC protein; Region: hflC; TIGR01932 572477004097 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 572477004098 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 572477004099 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 572477004100 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 572477004101 dimer interface [polypeptide binding]; other site 572477004102 motif 1; other site 572477004103 active site 572477004104 motif 2; other site 572477004105 motif 3; other site 572477004106 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 572477004107 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 572477004108 GDP-binding site [chemical binding]; other site 572477004109 ACT binding site; other site 572477004110 IMP binding site; other site 572477004111 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 572477004112 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 572477004113 G1 box; other site 572477004114 GTP/Mg2+ binding site [chemical binding]; other site 572477004115 G2 box; other site 572477004116 Switch I region; other site 572477004117 G3 box; other site 572477004118 Switch II region; other site 572477004119 G4 box; other site 572477004120 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 572477004121 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 572477004122 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572477004123 inhibitor-cofactor binding pocket; inhibition site 572477004124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477004125 catalytic residue [active] 572477004126 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 572477004127 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 572477004128 YccA-like proteins; Region: YccA_like; cd10433 572477004129 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 572477004130 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 572477004131 putative active site [active] 572477004132 putative metal binding residues [ion binding]; other site 572477004133 signature motif; other site 572477004134 putative dimer interface [polypeptide binding]; other site 572477004135 putative phosphate binding site [ion binding]; other site 572477004136 HDOD domain; Region: HDOD; pfam08668 572477004137 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 572477004138 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 572477004139 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 572477004140 PhoU domain; Region: PhoU; pfam01895 572477004141 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 572477004142 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572477004143 active site 572477004144 metal binding site [ion binding]; metal-binding site 572477004145 AAA domain; Region: AAA_17; pfam13207 572477004146 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 572477004147 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 572477004148 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 572477004149 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09733 572477004150 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 572477004151 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 572477004152 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 572477004153 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 572477004154 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 572477004155 DsrE/DsrF-like family; Region: DrsE; cl00672 572477004156 DsrH like protein; Region: DsrH; pfam04077 572477004157 DsrC like protein; Region: DsrC; pfam04358 572477004158 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 572477004159 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 572477004160 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 572477004161 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 572477004162 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572477004163 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572477004164 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 572477004165 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 572477004166 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 572477004167 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797 572477004168 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572477004169 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 572477004170 catalytic triad [active] 572477004171 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 572477004172 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 572477004173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477004174 Walker A motif; other site 572477004175 ATP binding site [chemical binding]; other site 572477004176 Walker B motif; other site 572477004177 arginine finger; other site 572477004178 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 572477004179 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 572477004180 Predicted membrane protein [Function unknown]; Region: COG3766 572477004181 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 572477004182 Hemerythrin-like domain; Region: Hr-like; cd12108 572477004183 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 572477004184 GTP-binding protein Der; Reviewed; Region: PRK00093 572477004185 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 572477004186 G1 box; other site 572477004187 GTP/Mg2+ binding site [chemical binding]; other site 572477004188 Switch I region; other site 572477004189 G2 box; other site 572477004190 Switch II region; other site 572477004191 G3 box; other site 572477004192 G4 box; other site 572477004193 G5 box; other site 572477004194 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 572477004195 G1 box; other site 572477004196 GTP/Mg2+ binding site [chemical binding]; other site 572477004197 Switch I region; other site 572477004198 G2 box; other site 572477004199 G3 box; other site 572477004200 Switch II region; other site 572477004201 G4 box; other site 572477004202 G5 box; other site 572477004203 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 572477004204 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 572477004205 Trp docking motif [polypeptide binding]; other site 572477004206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 572477004207 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 572477004208 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 572477004209 dimer interface [polypeptide binding]; other site 572477004210 motif 1; other site 572477004211 active site 572477004212 motif 2; other site 572477004213 motif 3; other site 572477004214 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 572477004215 anticodon binding site; other site 572477004216 Helix-turn-helix domain; Region: HTH_25; pfam13413 572477004217 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 572477004218 TPR repeat; Region: TPR_11; pfam13414 572477004219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477004220 binding surface 572477004221 TPR motif; other site 572477004222 Tetratricopeptide repeat; Region: TPR_12; pfam13424 572477004223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 572477004224 binding surface 572477004225 TPR motif; other site 572477004226 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 572477004227 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477004228 FeS/SAM binding site; other site 572477004229 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 572477004230 active site 572477004231 multimer interface [polypeptide binding]; other site 572477004232 peptide chain release factor 2; Validated; Region: prfB; PRK00578 572477004233 This domain is found in peptide chain release factors; Region: PCRF; smart00937 572477004234 RF-1 domain; Region: RF-1; pfam00472 572477004235 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 572477004236 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 572477004237 dimer interface [polypeptide binding]; other site 572477004238 putative anticodon binding site; other site 572477004239 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 572477004240 motif 1; other site 572477004241 active site 572477004242 motif 2; other site 572477004243 motif 3; other site 572477004244 putative global regulator; Reviewed; Region: PRK09559 572477004245 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 572477004246 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 572477004247 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 572477004248 RNB domain; Region: RNB; pfam00773 572477004249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 572477004250 Peptidase M15; Region: Peptidase_M15_3; cl01194 572477004251 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 572477004252 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 572477004253 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 572477004254 N-acetyl-D-glucosamine binding site [chemical binding]; other site 572477004255 catalytic residue [active] 572477004256 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 572477004257 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 572477004258 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 572477004259 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 572477004260 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 572477004261 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 572477004262 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 572477004263 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 572477004264 GAF domain; Region: GAF; pfam01590 572477004265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477004266 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 572477004267 Walker A motif; other site 572477004268 ATP binding site [chemical binding]; other site 572477004269 Walker B motif; other site 572477004270 arginine finger; other site 572477004271 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 572477004272 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 572477004273 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 572477004274 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 572477004275 Sulfate transporter family; Region: Sulfate_transp; pfam00916 572477004276 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 572477004277 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 572477004278 Uncharacterized conserved protein [Function unknown]; Region: COG1359 572477004279 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 572477004280 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 572477004281 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 572477004282 Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865 572477004283 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 572477004284 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 572477004285 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 572477004286 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 572477004287 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477004288 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477004289 metal binding site [ion binding]; metal-binding site 572477004290 active site 572477004291 I-site; other site 572477004292 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 572477004293 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 572477004294 active site 572477004295 FMN binding site [chemical binding]; other site 572477004296 substrate binding site [chemical binding]; other site 572477004297 homotetramer interface [polypeptide binding]; other site 572477004298 catalytic residue [active] 572477004299 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 572477004300 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 572477004301 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 572477004302 protein binding site [polypeptide binding]; other site 572477004303 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 572477004304 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 572477004305 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 572477004306 GTP binding site; other site 572477004307 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 572477004308 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 572477004309 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 572477004310 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 572477004311 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 572477004312 molybdopterin cofactor binding site; other site 572477004313 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 572477004314 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 572477004315 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 572477004316 putative molybdopterin cofactor binding site; other site 572477004317 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 572477004318 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 572477004319 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 572477004320 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 572477004321 Protein of unknown function (DUF3457); Region: DUF3457; cl08122 572477004322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 572477004323 glutathione reductase; Validated; Region: PRK06116 572477004324 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572477004325 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572477004326 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572477004327 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 572477004328 catalytic triad [active] 572477004329 dimer interface [polypeptide binding]; other site 572477004330 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 572477004331 glucokinase, proteobacterial type; Region: glk; TIGR00749 572477004332 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 572477004333 nucleotide binding site [chemical binding]; other site 572477004334 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 572477004335 Surface antigen; Region: Bac_surface_Ag; pfam01103 572477004336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 572477004337 Family of unknown function (DUF490); Region: DUF490; pfam04357 572477004338 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 572477004339 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 572477004340 putative acyl-acceptor binding pocket; other site 572477004341 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 572477004342 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 572477004343 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 572477004344 Walker A/P-loop; other site 572477004345 ATP binding site [chemical binding]; other site 572477004346 Q-loop/lid; other site 572477004347 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 572477004348 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 572477004349 ABC transporter signature motif; other site 572477004350 Walker B; other site 572477004351 D-loop; other site 572477004352 H-loop/switch region; other site 572477004353 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 572477004354 FtsZ protein binding site [polypeptide binding]; other site 572477004355 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 572477004356 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 572477004357 nucleotide binding pocket [chemical binding]; other site 572477004358 K-X-D-G motif; other site 572477004359 catalytic site [active] 572477004360 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 572477004361 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 572477004362 Helix-hairpin-helix motif; Region: HHH; pfam00633 572477004363 helix-hairpin-helix signature motif; other site 572477004364 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 572477004365 Dimer interface [polypeptide binding]; other site 572477004366 BRCT sequence motif; other site 572477004367 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 572477004368 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 572477004369 YciI-like protein; Reviewed; Region: PRK11370 572477004370 intracellular septation protein A; Reviewed; Region: PRK00259 572477004371 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 572477004372 amino acid carrier protein; Region: agcS; TIGR00835 572477004373 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572477004374 Ligand Binding Site [chemical binding]; other site 572477004375 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 572477004376 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 572477004377 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572477004378 Soluble P-type ATPase [General function prediction only]; Region: COG4087 572477004379 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 572477004380 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 572477004381 heme binding pocket [chemical binding]; other site 572477004382 heme ligand [chemical binding]; other site 572477004383 GAF domain; Region: GAF; pfam01590 572477004384 Phytochrome region; Region: PHY; pfam00360 572477004385 ATP synthase subunit D; Region: ATP-synt_D; pfam01813 572477004386 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 572477004387 V-type ATP synthase subunit B; Provisional; Region: PRK04196 572477004388 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 572477004389 Walker A motif homologous position; other site 572477004390 Walker B motif; other site 572477004391 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 572477004392 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 572477004393 Transglycosylase; Region: Transgly; pfam00912 572477004394 V-type ATP synthase subunit A; Provisional; Region: PRK04192 572477004395 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 572477004396 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 572477004397 Walker A motif/ATP binding site; other site 572477004398 Walker B motif; other site 572477004399 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 572477004400 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 572477004401 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 572477004402 V-type ATP synthase subunit I; Validated; Region: PRK05771 572477004403 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 572477004404 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 572477004405 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 572477004406 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 572477004407 Ligand binding site; other site 572477004408 Putative Catalytic site; other site 572477004409 DXD motif; other site 572477004410 Predicted membrane protein [Function unknown]; Region: COG2246 572477004411 GtrA-like protein; Region: GtrA; pfam04138 572477004412 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 572477004413 Clp amino terminal domain; Region: Clp_N; pfam02861 572477004414 Clp amino terminal domain; Region: Clp_N; pfam02861 572477004415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477004416 Walker A motif; other site 572477004417 ATP binding site [chemical binding]; other site 572477004418 Walker B motif; other site 572477004419 arginine finger; other site 572477004420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477004421 Walker A motif; other site 572477004422 ATP binding site [chemical binding]; other site 572477004423 Walker B motif; other site 572477004424 arginine finger; other site 572477004425 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 572477004426 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 572477004427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477004428 Walker A motif; other site 572477004429 ATP binding site [chemical binding]; other site 572477004430 Walker B motif; other site 572477004431 arginine finger; other site 572477004432 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 572477004433 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 572477004434 MgtE intracellular N domain; Region: MgtE_N; smart00924 572477004435 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 572477004436 Divalent cation transporter; Region: MgtE; cl00786 572477004437 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 572477004438 substrate binding site [chemical binding]; other site 572477004439 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572477004440 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572477004441 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 572477004442 putative dimerization interface [polypeptide binding]; other site 572477004443 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 572477004444 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 572477004445 dimer interface [polypeptide binding]; other site 572477004446 catalytic residue [active] 572477004447 metal binding site [ion binding]; metal-binding site 572477004448 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 572477004449 multimerization interface [polypeptide binding]; other site 572477004450 MoxR-like ATPases [General function prediction only]; Region: COG0714 572477004451 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 572477004452 Walker A motif; other site 572477004453 ATP binding site [chemical binding]; other site 572477004454 Walker B motif; other site 572477004455 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 572477004456 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 572477004457 metal ion-dependent adhesion site (MIDAS); other site 572477004458 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572477004459 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477004460 dimer interface [polypeptide binding]; other site 572477004461 putative CheW interface [polypeptide binding]; other site 572477004462 Response regulator receiver domain; Region: Response_reg; pfam00072 572477004463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477004464 active site 572477004465 phosphorylation site [posttranslational modification] 572477004466 intermolecular recognition site; other site 572477004467 dimerization interface [polypeptide binding]; other site 572477004468 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 572477004469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477004470 active site 572477004471 phosphorylation site [posttranslational modification] 572477004472 intermolecular recognition site; other site 572477004473 dimerization interface [polypeptide binding]; other site 572477004474 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572477004475 Zn2+ binding site [ion binding]; other site 572477004476 Mg2+ binding site [ion binding]; other site 572477004477 CHASE domain; Region: CHASE; pfam03924 572477004478 PAS fold; Region: PAS_4; pfam08448 572477004479 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477004480 putative active site [active] 572477004481 heme pocket [chemical binding]; other site 572477004482 PAS fold; Region: PAS_4; pfam08448 572477004483 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477004484 putative active site [active] 572477004485 heme pocket [chemical binding]; other site 572477004486 PAS fold; Region: PAS_4; pfam08448 572477004487 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477004488 putative active site [active] 572477004489 heme pocket [chemical binding]; other site 572477004490 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477004491 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 572477004492 putative active site [active] 572477004493 heme pocket [chemical binding]; other site 572477004494 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477004495 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477004496 putative active site [active] 572477004497 heme pocket [chemical binding]; other site 572477004498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477004499 dimer interface [polypeptide binding]; other site 572477004500 phosphorylation site [posttranslational modification] 572477004501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477004502 ATP binding site [chemical binding]; other site 572477004503 Mg2+ binding site [ion binding]; other site 572477004504 G-X-G motif; other site 572477004505 Response regulator receiver domain; Region: Response_reg; pfam00072 572477004506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477004507 active site 572477004508 phosphorylation site [posttranslational modification] 572477004509 intermolecular recognition site; other site 572477004510 dimerization interface [polypeptide binding]; other site 572477004511 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 572477004512 putative binding surface; other site 572477004513 active site 572477004514 CheB methylesterase; Region: CheB_methylest; pfam01339 572477004515 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 572477004516 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 572477004517 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 572477004518 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 572477004519 PAS domain; Region: PAS_10; pfam13596 572477004520 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477004521 putative active site [active] 572477004522 heme pocket [chemical binding]; other site 572477004523 PAS domain S-box; Region: sensory_box; TIGR00229 572477004524 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477004525 putative active site [active] 572477004526 heme pocket [chemical binding]; other site 572477004527 PAS fold; Region: PAS_3; pfam08447 572477004528 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 572477004529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477004530 PAS fold; Region: PAS_3; pfam08447 572477004531 putative active site [active] 572477004532 heme pocket [chemical binding]; other site 572477004533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477004534 dimer interface [polypeptide binding]; other site 572477004535 phosphorylation site [posttranslational modification] 572477004536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477004537 ATP binding site [chemical binding]; other site 572477004538 Mg2+ binding site [ion binding]; other site 572477004539 G-X-G motif; other site 572477004540 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477004541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477004542 active site 572477004543 phosphorylation site [posttranslational modification] 572477004544 intermolecular recognition site; other site 572477004545 dimerization interface [polypeptide binding]; other site 572477004546 Response regulator receiver domain; Region: Response_reg; pfam00072 572477004547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477004548 active site 572477004549 phosphorylation site [posttranslational modification] 572477004550 intermolecular recognition site; other site 572477004551 dimerization interface [polypeptide binding]; other site 572477004552 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477004553 putative binding surface; other site 572477004554 active site 572477004555 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477004556 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477004557 putative active site [active] 572477004558 heme pocket [chemical binding]; other site 572477004559 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477004560 dimer interface [polypeptide binding]; other site 572477004561 phosphorylation site [posttranslational modification] 572477004562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477004563 ATP binding site [chemical binding]; other site 572477004564 Mg2+ binding site [ion binding]; other site 572477004565 G-X-G motif; other site 572477004566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477004567 Response regulator receiver domain; Region: Response_reg; pfam00072 572477004568 active site 572477004569 phosphorylation site [posttranslational modification] 572477004570 intermolecular recognition site; other site 572477004571 dimerization interface [polypeptide binding]; other site 572477004572 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572477004573 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572477004574 substrate binding pocket [chemical binding]; other site 572477004575 membrane-bound complex binding site; other site 572477004576 hinge residues; other site 572477004577 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 572477004578 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477004579 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477004580 putative active site [active] 572477004581 heme pocket [chemical binding]; other site 572477004582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477004583 dimer interface [polypeptide binding]; other site 572477004584 phosphorylation site [posttranslational modification] 572477004585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477004586 ATP binding site [chemical binding]; other site 572477004587 Mg2+ binding site [ion binding]; other site 572477004588 G-X-G motif; other site 572477004589 Response regulator receiver domain; Region: Response_reg; pfam00072 572477004590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477004591 active site 572477004592 phosphorylation site [posttranslational modification] 572477004593 intermolecular recognition site; other site 572477004594 dimerization interface [polypeptide binding]; other site 572477004595 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477004596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477004597 active site 572477004598 phosphorylation site [posttranslational modification] 572477004599 intermolecular recognition site; other site 572477004600 dimerization interface [polypeptide binding]; other site 572477004601 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477004602 putative binding surface; other site 572477004603 active site 572477004604 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 572477004605 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572477004606 putative DNA binding site [nucleotide binding]; other site 572477004607 putative Zn2+ binding site [ion binding]; other site 572477004608 AsnC family; Region: AsnC_trans_reg; pfam01037 572477004609 2-isopropylmalate synthase; Validated; Region: PRK03739 572477004610 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 572477004611 active site 572477004612 catalytic residues [active] 572477004613 metal binding site [ion binding]; metal-binding site 572477004614 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 572477004615 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 572477004616 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 572477004617 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572477004618 Zn2+ binding site [ion binding]; other site 572477004619 Mg2+ binding site [ion binding]; other site 572477004620 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 572477004621 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 572477004622 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 572477004623 Walker A/P-loop; other site 572477004624 ATP binding site [chemical binding]; other site 572477004625 Q-loop/lid; other site 572477004626 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 572477004627 Q-loop/lid; other site 572477004628 ABC transporter signature motif; other site 572477004629 Walker B; other site 572477004630 D-loop; other site 572477004631 H-loop/switch region; other site 572477004632 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 572477004633 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 572477004634 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 572477004635 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 572477004636 GrpE; Region: GrpE; pfam01025 572477004637 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 572477004638 dimer interface [polypeptide binding]; other site 572477004639 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 572477004640 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 572477004641 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 572477004642 nucleotide binding site [chemical binding]; other site 572477004643 chaperone protein DnaJ; Provisional; Region: PRK14300 572477004644 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 572477004645 HSP70 interaction site [polypeptide binding]; other site 572477004646 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 572477004647 substrate binding site [polypeptide binding]; other site 572477004648 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 572477004649 Zn binding sites [ion binding]; other site 572477004650 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 572477004651 dimer interface [polypeptide binding]; other site 572477004652 Thiamine monophosphate kinase [Coenzyme metabolism]; Region: ThiL; COG0611 572477004653 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 572477004654 dimerization interface [polypeptide binding]; other site 572477004655 putative ATP binding site [chemical binding]; other site 572477004656 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 572477004657 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 572477004658 G1 box; other site 572477004659 putative GEF interaction site [polypeptide binding]; other site 572477004660 GTP/Mg2+ binding site [chemical binding]; other site 572477004661 Switch I region; other site 572477004662 G2 box; other site 572477004663 G3 box; other site 572477004664 Switch II region; other site 572477004665 G4 box; other site 572477004666 G5 box; other site 572477004667 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 572477004668 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 572477004669 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 572477004670 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 572477004671 selenocysteine synthase; Provisional; Region: PRK04311 572477004672 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 572477004673 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572477004674 catalytic residue [active] 572477004675 Protein of unknown function (DUF808); Region: DUF808; pfam05661 572477004676 SCP-2 sterol transfer family; Region: SCP2; cl01225 572477004677 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 572477004678 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 572477004679 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 572477004680 hypothetical protein; Provisional; Region: PRK05208 572477004681 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477004682 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477004683 metal binding site [ion binding]; metal-binding site 572477004684 active site 572477004685 I-site; other site 572477004686 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 572477004687 BCCT family transporter; Region: BCCT; cl00569 572477004688 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 572477004689 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 572477004690 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572477004691 catalytic residue [active] 572477004692 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 572477004693 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 572477004694 trimerization site [polypeptide binding]; other site 572477004695 active site 572477004696 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 572477004697 NifU-like domain; Region: NifU; pfam01106 572477004698 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 572477004699 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572477004700 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572477004701 NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007 572477004702 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 572477004703 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572477004704 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572477004705 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 572477004706 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 572477004707 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 572477004708 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 572477004709 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 572477004710 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 572477004711 acyl-activating enzyme (AAE) consensus motif; other site 572477004712 putative AMP binding site [chemical binding]; other site 572477004713 putative active site [active] 572477004714 putative CoA binding site [chemical binding]; other site 572477004715 phosphoglucomutase; Region: PLN02307 572477004716 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 572477004717 substrate binding site [chemical binding]; other site 572477004718 dimer interface [polypeptide binding]; other site 572477004719 active site 572477004720 metal binding site [ion binding]; metal-binding site 572477004721 heat shock protein 90; Provisional; Region: PRK05218 572477004722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477004723 ATP binding site [chemical binding]; other site 572477004724 Mg2+ binding site [ion binding]; other site 572477004725 G-X-G motif; other site 572477004726 adenylate kinase; Reviewed; Region: adk; PRK00279 572477004727 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 572477004728 AMP-binding site [chemical binding]; other site 572477004729 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 572477004730 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572477004731 catalytic residues [active] 572477004732 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 572477004733 Transcriptional regulator; Region: Rrf2; cl17282 572477004734 Rrf2 family protein; Region: rrf2_super; TIGR00738 572477004735 HemK family putative methylases; Region: hemK_fam; TIGR00536 572477004736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477004737 S-adenosylmethionine binding site [chemical binding]; other site 572477004738 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 572477004739 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477004740 FeS/SAM binding site; other site 572477004741 HemN C-terminal domain; Region: HemN_C; pfam06969 572477004742 trigger factor; Provisional; Region: tig; PRK01490 572477004743 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 572477004744 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 572477004745 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 572477004746 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 572477004747 oligomer interface [polypeptide binding]; other site 572477004748 active site residues [active] 572477004749 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 572477004750 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 572477004751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477004752 Walker A motif; other site 572477004753 ATP binding site [chemical binding]; other site 572477004754 Walker B motif; other site 572477004755 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 572477004756 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 572477004757 Found in ATP-dependent protease La (LON); Region: LON; smart00464 572477004758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477004759 Walker A motif; other site 572477004760 ATP binding site [chemical binding]; other site 572477004761 Walker B motif; other site 572477004762 arginine finger; other site 572477004763 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 572477004764 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 572477004765 IHF dimer interface [polypeptide binding]; other site 572477004766 IHF - DNA interface [nucleotide binding]; other site 572477004767 periplasmic folding chaperone; Provisional; Region: PRK10788 572477004768 SurA N-terminal domain; Region: SurA_N_3; pfam13624 572477004769 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 572477004770 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 572477004771 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 572477004772 NAD binding site [chemical binding]; other site 572477004773 homotetramer interface [polypeptide binding]; other site 572477004774 homodimer interface [polypeptide binding]; other site 572477004775 substrate binding site [chemical binding]; other site 572477004776 active site 572477004777 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 572477004778 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 572477004779 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 572477004780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572477004781 dimer interface [polypeptide binding]; other site 572477004782 conserved gate region; other site 572477004783 putative PBP binding loops; other site 572477004784 ABC-ATPase subunit interface; other site 572477004785 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 572477004786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572477004787 dimer interface [polypeptide binding]; other site 572477004788 conserved gate region; other site 572477004789 putative PBP binding loops; other site 572477004790 ABC-ATPase subunit interface; other site 572477004791 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 572477004792 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572477004793 Walker A/P-loop; other site 572477004794 ATP binding site [chemical binding]; other site 572477004795 Q-loop/lid; other site 572477004796 ABC transporter signature motif; other site 572477004797 Walker B; other site 572477004798 D-loop; other site 572477004799 H-loop/switch region; other site 572477004800 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 572477004801 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 572477004802 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572477004803 Walker A/P-loop; other site 572477004804 ATP binding site [chemical binding]; other site 572477004805 Q-loop/lid; other site 572477004806 ABC transporter signature motif; other site 572477004807 Walker B; other site 572477004808 D-loop; other site 572477004809 H-loop/switch region; other site 572477004810 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 572477004811 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 572477004812 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 572477004813 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 572477004814 dimerization interface [polypeptide binding]; other site 572477004815 DPS ferroxidase diiron center [ion binding]; other site 572477004816 ion pore; other site 572477004817 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 572477004818 DNA-binding site [nucleotide binding]; DNA binding site 572477004819 RNA-binding motif; other site 572477004820 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 572477004821 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572477004822 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 572477004823 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 572477004824 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 572477004825 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 572477004826 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572477004827 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572477004828 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572477004829 active site residue [active] 572477004830 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 572477004831 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 572477004832 DXD motif; other site 572477004833 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 572477004834 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572477004835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477004836 homodimer interface [polypeptide binding]; other site 572477004837 catalytic residue [active] 572477004838 Protein of unknown function, DUF599; Region: DUF599; cl01575 572477004839 RRXRR protein; Region: RRXRR; pfam14239 572477004840 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572477004841 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 572477004842 active site 572477004843 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 572477004844 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572477004845 non-specific DNA binding site [nucleotide binding]; other site 572477004846 salt bridge; other site 572477004847 sequence-specific DNA binding site [nucleotide binding]; other site 572477004848 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 572477004849 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 572477004850 Ycf46; Provisional; Region: ycf46; CHL00195 572477004851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477004852 Walker A motif; other site 572477004853 ATP binding site [chemical binding]; other site 572477004854 Walker B motif; other site 572477004855 arginine finger; other site 572477004856 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 572477004857 nickel binding site [ion binding]; other site 572477004858 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 572477004859 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 572477004860 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 572477004861 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 572477004862 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 572477004863 HlyD family secretion protein; Region: HlyD_3; pfam13437 572477004864 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572477004865 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572477004866 Walker A/P-loop; other site 572477004867 ATP binding site [chemical binding]; other site 572477004868 Q-loop/lid; other site 572477004869 ABC transporter signature motif; other site 572477004870 Walker B; other site 572477004871 D-loop; other site 572477004872 H-loop/switch region; other site 572477004873 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 572477004874 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 572477004875 Protein of unknown function DUF262; Region: DUF262; pfam03235 572477004876 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 572477004877 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 572477004878 cofactor binding site; other site 572477004879 DNA binding site [nucleotide binding] 572477004880 substrate interaction site [chemical binding]; other site 572477004881 HlyD family secretion protein; Region: HlyD; pfam00529 572477004882 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 572477004883 HlyD family secretion protein; Region: HlyD_3; pfam13437 572477004884 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 572477004885 Fusaric acid resistance protein family; Region: FUSC; pfam04632 572477004886 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 572477004887 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572477004888 MarR family; Region: MarR_2; pfam12802 572477004889 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 572477004890 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 572477004891 putative NAD(P) binding site [chemical binding]; other site 572477004892 putative substrate binding site [chemical binding]; other site 572477004893 catalytic Zn binding site [ion binding]; other site 572477004894 structural Zn binding site [ion binding]; other site 572477004895 dimer interface [polypeptide binding]; other site 572477004896 YceI-like domain; Region: YceI; pfam04264 572477004897 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 572477004898 nucleoside/Zn binding site; other site 572477004899 dimer interface [polypeptide binding]; other site 572477004900 catalytic motif [active] 572477004901 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 572477004902 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 572477004903 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 572477004904 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 572477004905 putative active site [active] 572477004906 putative metal binding site [ion binding]; other site 572477004907 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 572477004908 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 572477004909 nucleotide binding site [chemical binding]; other site 572477004910 putative NEF/HSP70 interaction site [polypeptide binding]; other site 572477004911 SBD interface [polypeptide binding]; other site 572477004912 glycogen synthase; Provisional; Region: glgA; PRK00654 572477004913 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 572477004914 ADP-binding pocket [chemical binding]; other site 572477004915 homodimer interface [polypeptide binding]; other site 572477004916 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 572477004917 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 572477004918 active site 572477004919 catalytic site [active] 572477004920 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 572477004921 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 572477004922 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 572477004923 Protein of unknown function (DUF465); Region: DUF465; cl01070 572477004924 periplasmic chaperone; Provisional; Region: PRK10780 572477004925 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 572477004926 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 572477004927 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 572477004928 active site 572477004929 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 572477004930 Part of AAA domain; Region: AAA_19; pfam13245 572477004931 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 572477004932 DNA polymerase I; Provisional; Region: PRK05755 572477004933 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 572477004934 active site 572477004935 metal binding site 1 [ion binding]; metal-binding site 572477004936 putative 5' ssDNA interaction site; other site 572477004937 metal binding site 3; metal-binding site 572477004938 metal binding site 2 [ion binding]; metal-binding site 572477004939 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 572477004940 putative DNA binding site [nucleotide binding]; other site 572477004941 putative metal binding site [ion binding]; other site 572477004942 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 572477004943 active site 572477004944 catalytic site [active] 572477004945 substrate binding site [chemical binding]; other site 572477004946 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 572477004947 active site 572477004948 DNA binding site [nucleotide binding] 572477004949 catalytic site [active] 572477004950 CHASE domain; Region: CHASE; pfam03924 572477004951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477004952 PAS domain; Region: PAS_9; pfam13426 572477004953 putative active site [active] 572477004954 heme pocket [chemical binding]; other site 572477004955 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477004956 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477004957 dimer interface [polypeptide binding]; other site 572477004958 phosphorylation site [posttranslational modification] 572477004959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477004960 ATP binding site [chemical binding]; other site 572477004961 Mg2+ binding site [ion binding]; other site 572477004962 G-X-G motif; other site 572477004963 Response regulator receiver domain; Region: Response_reg; pfam00072 572477004964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477004965 active site 572477004966 phosphorylation site [posttranslational modification] 572477004967 intermolecular recognition site; other site 572477004968 dimerization interface [polypeptide binding]; other site 572477004969 Response regulator receiver domain; Region: Response_reg; pfam00072 572477004970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477004971 active site 572477004972 phosphorylation site [posttranslational modification] 572477004973 intermolecular recognition site; other site 572477004974 PAS domain S-box; Region: sensory_box; TIGR00229 572477004975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477004976 putative active site [active] 572477004977 heme pocket [chemical binding]; other site 572477004978 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477004979 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477004980 putative active site [active] 572477004981 heme pocket [chemical binding]; other site 572477004982 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477004983 dimer interface [polypeptide binding]; other site 572477004984 phosphorylation site [posttranslational modification] 572477004985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477004986 ATP binding site [chemical binding]; other site 572477004987 Mg2+ binding site [ion binding]; other site 572477004988 G-X-G motif; other site 572477004989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 572477004990 active site 572477004991 phosphorylation site [posttranslational modification] 572477004992 intermolecular recognition site; other site 572477004993 dimerization interface [polypeptide binding]; other site 572477004994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477004995 Response regulator receiver domain; Region: Response_reg; pfam00072 572477004996 active site 572477004997 phosphorylation site [posttranslational modification] 572477004998 intermolecular recognition site; other site 572477004999 dimerization interface [polypeptide binding]; other site 572477005000 Hpt domain; Region: Hpt; pfam01627 572477005001 putative binding surface; other site 572477005002 active site 572477005003 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 572477005004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477005005 putative active site [active] 572477005006 heme pocket [chemical binding]; other site 572477005007 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477005008 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477005009 putative active site [active] 572477005010 heme pocket [chemical binding]; other site 572477005011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477005012 dimer interface [polypeptide binding]; other site 572477005013 phosphorylation site [posttranslational modification] 572477005014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477005015 ATP binding site [chemical binding]; other site 572477005016 Mg2+ binding site [ion binding]; other site 572477005017 G-X-G motif; other site 572477005018 Response regulator receiver domain; Region: Response_reg; pfam00072 572477005019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477005020 active site 572477005021 phosphorylation site [posttranslational modification] 572477005022 intermolecular recognition site; other site 572477005023 dimerization interface [polypeptide binding]; other site 572477005024 ATP-dependent helicase HepA; Validated; Region: PRK04914 572477005025 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572477005026 ATP binding site [chemical binding]; other site 572477005027 putative Mg++ binding site [ion binding]; other site 572477005028 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572477005029 nucleotide binding region [chemical binding]; other site 572477005030 ATP-binding site [chemical binding]; other site 572477005031 Uncharacterized conserved protein [Function unknown]; Region: COG2835 572477005032 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 572477005033 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 572477005034 NifZ domain; Region: NifZ; pfam04319 572477005035 Nitrogen fixation protein NifW; Region: NifW; pfam03206 572477005036 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 572477005037 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 572477005038 active site 572477005039 catalytic residues [active] 572477005040 metal binding site [ion binding]; metal-binding site 572477005041 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 572477005042 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477005043 FeS/SAM binding site; other site 572477005044 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 572477005045 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 572477005046 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 572477005047 acyl-activating enzyme (AAE) consensus motif; other site 572477005048 active site 572477005049 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 572477005050 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 572477005051 putative acyl-acceptor binding pocket; other site 572477005052 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 572477005053 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 572477005054 homodimer interface [polypeptide binding]; other site 572477005055 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 572477005056 active site pocket [active] 572477005057 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477005058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477005059 dimer interface [polypeptide binding]; other site 572477005060 phosphorylation site [posttranslational modification] 572477005061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477005062 ATP binding site [chemical binding]; other site 572477005063 Mg2+ binding site [ion binding]; other site 572477005064 G-X-G motif; other site 572477005065 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 572477005066 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 572477005067 CoA-ligase; Region: Ligase_CoA; pfam00549 572477005068 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 572477005069 CoA binding domain; Region: CoA_binding; smart00881 572477005070 CoA-ligase; Region: Ligase_CoA; pfam00549 572477005071 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 572477005072 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 572477005073 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572477005074 catalytic residue [active] 572477005075 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 572477005076 DsrC like protein; Region: DsrC; pfam04358 572477005077 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 572477005078 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 572477005079 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 572477005080 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 572477005081 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 572477005082 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 572477005083 dimerization interface [polypeptide binding]; other site 572477005084 domain crossover interface; other site 572477005085 redox-dependent activation switch; other site 572477005086 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572477005087 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 572477005088 active site 572477005089 metal binding site [ion binding]; metal-binding site 572477005090 Domain of unknown function DUF77; Region: DUF77; pfam01910 572477005091 aconitate hydratase; Validated; Region: PRK09277 572477005092 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 572477005093 substrate binding site [chemical binding]; other site 572477005094 ligand binding site [chemical binding]; other site 572477005095 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 572477005096 substrate binding site [chemical binding]; other site 572477005097 putative lysogenization regulator; Reviewed; Region: PRK00218 572477005098 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 572477005099 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 572477005100 Ligand Binding Site [chemical binding]; other site 572477005101 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 572477005102 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 572477005103 putative active site [active] 572477005104 putative metal binding site [ion binding]; other site 572477005105 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 572477005106 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 572477005107 putative ribose interaction site [chemical binding]; other site 572477005108 putative ADP binding site [chemical binding]; other site 572477005109 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 572477005110 active site 572477005111 HIGH motif; other site 572477005112 nucleotide binding site [chemical binding]; other site 572477005113 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 572477005114 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 572477005115 ligand binding site; other site 572477005116 oligomer interface; other site 572477005117 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 572477005118 dimer interface [polypeptide binding]; other site 572477005119 N-terminal domain interface [polypeptide binding]; other site 572477005120 sulfate 1 binding site; other site 572477005121 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 572477005122 Predicted membrane protein [Function unknown]; Region: COG2119 572477005123 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 572477005124 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 572477005125 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 572477005126 HlyD family secretion protein; Region: HlyD_3; pfam13437 572477005127 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 572477005128 FeoC like transcriptional regulator; Region: FeoC; pfam09012 572477005129 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 572477005130 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 572477005131 G1 box; other site 572477005132 GTP/Mg2+ binding site [chemical binding]; other site 572477005133 Switch I region; other site 572477005134 G2 box; other site 572477005135 G3 box; other site 572477005136 Switch II region; other site 572477005137 G4 box; other site 572477005138 G5 box; other site 572477005139 Nucleoside recognition; Region: Gate; pfam07670 572477005140 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 572477005141 Nucleoside recognition; Region: Gate; pfam07670 572477005142 FeoA domain; Region: FeoA; pfam04023 572477005143 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 572477005144 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 572477005145 putative metal binding site [ion binding]; other site 572477005146 putative homodimer interface [polypeptide binding]; other site 572477005147 putative homotetramer interface [polypeptide binding]; other site 572477005148 putative homodimer-homodimer interface [polypeptide binding]; other site 572477005149 putative allosteric switch controlling residues; other site 572477005150 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 572477005151 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572477005152 dimerization interface [polypeptide binding]; other site 572477005153 putative DNA binding site [nucleotide binding]; other site 572477005154 putative Zn2+ binding site [ion binding]; other site 572477005155 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 572477005156 Low molecular weight phosphatase family; Region: LMWPc; cd00115 572477005157 active site 572477005158 Predicted permeases [General function prediction only]; Region: COG0701 572477005159 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 572477005160 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 572477005161 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572477005162 active site 572477005163 metal binding site [ion binding]; metal-binding site 572477005164 DNA binding site [nucleotide binding] 572477005165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477005166 AAA domain; Region: AAA_23; pfam13476 572477005167 Walker A/P-loop; other site 572477005168 ATP binding site [chemical binding]; other site 572477005169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477005170 ABC transporter signature motif; other site 572477005171 Walker B; other site 572477005172 D-loop; other site 572477005173 H-loop/switch region; other site 572477005174 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477005175 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 572477005176 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477005177 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477005178 metal binding site [ion binding]; metal-binding site 572477005179 active site 572477005180 I-site; other site 572477005181 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 572477005182 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 572477005183 Ligand binding site; other site 572477005184 Putative Catalytic site; other site 572477005185 DXD motif; other site 572477005186 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 572477005187 DNA methylase; Region: N6_N4_Mtase; cl17433 572477005188 DNA methylase; Region: N6_N4_Mtase; pfam01555 572477005189 Predicted ATPase [General function prediction only]; Region: COG4637 572477005190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477005191 Walker A/P-loop; other site 572477005192 ATP binding site [chemical binding]; other site 572477005193 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 572477005194 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 572477005195 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 572477005196 head completion protein; Provisional; Region: 4; PHA02552 572477005197 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 572477005198 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 572477005199 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 572477005200 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 572477005201 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 572477005202 homodimer interface [polypeptide binding]; other site 572477005203 substrate-cofactor binding pocket; other site 572477005204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477005205 catalytic residue [active] 572477005206 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 572477005207 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 572477005208 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 572477005209 GIY-YIG motif/motif A; other site 572477005210 active site 572477005211 catalytic site [active] 572477005212 putative DNA binding site [nucleotide binding]; other site 572477005213 metal binding site [ion binding]; metal-binding site 572477005214 UvrB/uvrC motif; Region: UVR; pfam02151 572477005215 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 572477005216 HDOD domain; Region: HDOD; pfam08668 572477005217 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 572477005218 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572477005219 putative inner membrane peptidase; Provisional; Region: PRK11778 572477005220 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 572477005221 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 572477005222 tandem repeat interface [polypeptide binding]; other site 572477005223 oligomer interface [polypeptide binding]; other site 572477005224 active site residues [active] 572477005225 thymidylate synthase; Reviewed; Region: thyA; PRK01827 572477005226 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 572477005227 dimerization interface [polypeptide binding]; other site 572477005228 active site 572477005229 phosphoglyceromutase; Provisional; Region: PRK05434 572477005230 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 572477005231 N-acetylglutamate synthase; Validated; Region: PRK05279 572477005232 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 572477005233 putative feedback inhibition sensing region; other site 572477005234 putative nucleotide binding site [chemical binding]; other site 572477005235 putative substrate binding site [chemical binding]; other site 572477005236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572477005237 Coenzyme A binding pocket [chemical binding]; other site 572477005238 hypothetical protein; Provisional; Region: PRK11281 572477005239 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 572477005240 Mechanosensitive ion channel; Region: MS_channel; pfam00924 572477005241 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572477005242 Ligand Binding Site [chemical binding]; other site 572477005243 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572477005244 Ligand Binding Site [chemical binding]; other site 572477005245 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 572477005246 TrkA-N domain; Region: TrkA_N; pfam02254 572477005247 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 572477005248 classical (c) SDRs; Region: SDR_c; cd05233 572477005249 NAD(P) binding site [chemical binding]; other site 572477005250 active site 572477005251 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 572477005252 classical (c) SDRs; Region: SDR_c; cd05233 572477005253 NAD(P) binding site [chemical binding]; other site 572477005254 active site 572477005255 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 572477005256 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 572477005257 metal binding site 2 [ion binding]; metal-binding site 572477005258 putative DNA binding helix; other site 572477005259 metal binding site 1 [ion binding]; metal-binding site 572477005260 dimer interface [polypeptide binding]; other site 572477005261 structural Zn2+ binding site [ion binding]; other site 572477005262 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 572477005263 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572477005264 ABC-ATPase subunit interface; other site 572477005265 dimer interface [polypeptide binding]; other site 572477005266 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 572477005267 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 572477005268 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 572477005269 HDOD domain; Region: HDOD; pfam08668 572477005270 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 572477005271 PilZ domain; Region: PilZ; pfam07238 572477005272 Putative motility protein; Region: YjfB_motility; pfam14070 572477005273 SprA-related family; Region: SprA-related; pfam12118 572477005274 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 572477005275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 572477005276 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477005277 dimerization interface [polypeptide binding]; other site 572477005278 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572477005279 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477005280 dimer interface [polypeptide binding]; other site 572477005281 putative CheW interface [polypeptide binding]; other site 572477005282 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 572477005283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477005284 active site 572477005285 phosphorylation site [posttranslational modification] 572477005286 intermolecular recognition site; other site 572477005287 dimerization interface [polypeptide binding]; other site 572477005288 CheB methylesterase; Region: CheB_methylest; pfam01339 572477005289 CheD chemotactic sensory transduction; Region: CheD; cl00810 572477005290 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 572477005291 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 572477005292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477005293 S-adenosylmethionine binding site [chemical binding]; other site 572477005294 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 572477005295 CHASE3 domain; Region: CHASE3; cl05000 572477005296 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572477005297 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477005298 dimer interface [polypeptide binding]; other site 572477005299 putative CheW interface [polypeptide binding]; other site 572477005300 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 572477005301 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477005302 putative binding surface; other site 572477005303 active site 572477005304 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 572477005305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477005306 ATP binding site [chemical binding]; other site 572477005307 Mg2+ binding site [ion binding]; other site 572477005308 G-X-G motif; other site 572477005309 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 572477005310 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 572477005311 anti sigma factor interaction site; other site 572477005312 regulatory phosphorylation site [posttranslational modification]; other site 572477005313 RRXRR protein; Region: RRXRR; pfam14239 572477005314 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572477005315 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 572477005316 active site 572477005317 Response regulator receiver domain; Region: Response_reg; pfam00072 572477005318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477005319 active site 572477005320 phosphorylation site [posttranslational modification] 572477005321 intermolecular recognition site; other site 572477005322 dimerization interface [polypeptide binding]; other site 572477005323 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572477005324 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477005325 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 572477005326 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 572477005327 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 572477005328 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572477005329 active site residue [active] 572477005330 FliW protein; Region: FliW; cl00740 572477005331 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 572477005332 AccI restriction endonuclease; Region: RE_AccI; pfam09545 572477005333 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 572477005334 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 572477005335 dimerization interface [polypeptide binding]; other site 572477005336 ATP binding site [chemical binding]; other site 572477005337 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 572477005338 dimerization interface [polypeptide binding]; other site 572477005339 ATP binding site [chemical binding]; other site 572477005340 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 572477005341 putative active site [active] 572477005342 catalytic triad [active] 572477005343 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 572477005344 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 572477005345 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 572477005346 ribonuclease R; Region: RNase_R; TIGR02063 572477005347 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 572477005348 RNB domain; Region: RNB; pfam00773 572477005349 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 572477005350 RNA binding site [nucleotide binding]; other site 572477005351 adenylosuccinate lyase; Provisional; Region: PRK09285 572477005352 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 572477005353 tetramer interface [polypeptide binding]; other site 572477005354 active site 572477005355 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 572477005356 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 572477005357 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 572477005358 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 572477005359 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 572477005360 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572477005361 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 572477005362 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 572477005363 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 572477005364 substrate binding site [chemical binding]; other site 572477005365 active site 572477005366 catalytic residues [active] 572477005367 heterodimer interface [polypeptide binding]; other site 572477005368 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 572477005369 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 572477005370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477005371 catalytic residue [active] 572477005372 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 572477005373 active site 572477005374 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 572477005375 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 572477005376 dimerization interface 3.5A [polypeptide binding]; other site 572477005377 active site 572477005378 FimV N-terminal domain; Region: FimV_core; TIGR03505 572477005379 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 572477005380 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 572477005381 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 572477005382 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 572477005383 tartrate dehydrogenase; Region: TTC; TIGR02089 572477005384 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 572477005385 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 572477005386 substrate binding site [chemical binding]; other site 572477005387 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 572477005388 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 572477005389 substrate binding site [chemical binding]; other site 572477005390 ligand binding site [chemical binding]; other site 572477005391 YcfA-like protein; Region: YcfA; pfam07927 572477005392 Bpu10I restriction endonuclease; Region: RE_Bpu10I; pfam09549 572477005393 Methyltransferase domain; Region: Methyltransf_26; pfam13659 572477005394 Type II/IV secretion system protein; Region: T2SE; pfam00437 572477005395 seryl-tRNA synthetase; Provisional; Region: PRK05431 572477005396 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 572477005397 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 572477005398 dimer interface [polypeptide binding]; other site 572477005399 active site 572477005400 motif 1; other site 572477005401 motif 2; other site 572477005402 motif 3; other site 572477005403 Methyltransferase domain; Region: Methyltransf_11; pfam08241 572477005404 S-adenosylmethionine binding site [chemical binding]; other site 572477005405 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 572477005406 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 572477005407 putative oligomer interface [polypeptide binding]; other site 572477005408 putative active site [active] 572477005409 metal binding site [ion binding]; metal-binding site 572477005410 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 572477005411 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572477005412 Coenzyme A binding pocket [chemical binding]; other site 572477005413 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572477005414 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 572477005415 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 572477005416 active site 572477005417 dimer interface [polypeptide binding]; other site 572477005418 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 572477005419 Ligand Binding Site [chemical binding]; other site 572477005420 Molecular Tunnel; other site 572477005421 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 572477005422 HicB family; Region: HicB; pfam05534 572477005423 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 572477005424 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 572477005425 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 572477005426 substrate binding pocket [chemical binding]; other site 572477005427 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 572477005428 B12 binding site [chemical binding]; other site 572477005429 cobalt ligand [ion binding]; other site 572477005430 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 572477005431 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572477005432 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572477005433 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 572477005434 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 572477005435 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572477005436 catalytic residue [active] 572477005437 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 572477005438 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 572477005439 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 572477005440 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 572477005441 active site 572477005442 catalytic site [active] 572477005443 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 572477005444 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 572477005445 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 572477005446 active site 572477005447 dimer interface [polypeptide binding]; other site 572477005448 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 572477005449 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 572477005450 N-acetyl-D-glucosamine binding site [chemical binding]; other site 572477005451 catalytic residue [active] 572477005452 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572477005453 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 572477005454 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 572477005455 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572477005456 active site 572477005457 metal binding site [ion binding]; metal-binding site 572477005458 hexamer interface [polypeptide binding]; other site 572477005459 Acylphosphatase; Region: Acylphosphatase; cl00551 572477005460 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 572477005461 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 572477005462 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 572477005463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477005464 Walker A motif; other site 572477005465 ATP binding site [chemical binding]; other site 572477005466 Walker B motif; other site 572477005467 arginine finger; other site 572477005468 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 572477005469 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 572477005470 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 572477005471 dimerization interface [polypeptide binding]; other site 572477005472 putative ATP binding site [chemical binding]; other site 572477005473 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 572477005474 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 572477005475 active site 572477005476 substrate binding site [chemical binding]; other site 572477005477 cosubstrate binding site; other site 572477005478 catalytic site [active] 572477005479 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 572477005480 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 572477005481 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 572477005482 dimer interface [polypeptide binding]; other site 572477005483 ADP-ribose binding site [chemical binding]; other site 572477005484 active site 572477005485 nudix motif; other site 572477005486 metal binding site [ion binding]; metal-binding site 572477005487 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 572477005488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477005489 active site 572477005490 phosphorylation site [posttranslational modification] 572477005491 intermolecular recognition site; other site 572477005492 dimerization interface [polypeptide binding]; other site 572477005493 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572477005494 DNA binding site [nucleotide binding] 572477005495 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477005496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 572477005497 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477005498 dimer interface [polypeptide binding]; other site 572477005499 phosphorylation site [posttranslational modification] 572477005500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477005501 ATP binding site [chemical binding]; other site 572477005502 Mg2+ binding site [ion binding]; other site 572477005503 G-X-G motif; other site 572477005504 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 572477005505 IHF dimer interface [polypeptide binding]; other site 572477005506 IHF - DNA interface [nucleotide binding]; other site 572477005507 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 572477005508 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 572477005509 RNA binding site [nucleotide binding]; other site 572477005510 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 572477005511 RNA binding site [nucleotide binding]; other site 572477005512 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 572477005513 RNA binding site [nucleotide binding]; other site 572477005514 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 572477005515 RNA binding site [nucleotide binding]; other site 572477005516 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 572477005517 RNA binding site [nucleotide binding]; other site 572477005518 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 572477005519 RNA binding site [nucleotide binding]; other site 572477005520 cytidylate kinase; Provisional; Region: cmk; PRK00023 572477005521 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 572477005522 CMP-binding site; other site 572477005523 The sites determining sugar specificity; other site 572477005524 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 572477005525 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 572477005526 hinge; other site 572477005527 active site 572477005528 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 572477005529 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 572477005530 trimer interface [polypeptide binding]; other site 572477005531 active site 572477005532 UDP-glucose 4-epimerase; Region: PLN02240 572477005533 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 572477005534 NAD binding site [chemical binding]; other site 572477005535 homodimer interface [polypeptide binding]; other site 572477005536 active site 572477005537 substrate binding site [chemical binding]; other site 572477005538 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 572477005539 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 572477005540 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 572477005541 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 572477005542 Predicted small secreted protein [Function unknown]; Region: COG5510 572477005543 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 572477005544 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 572477005545 amphipathic channel; other site 572477005546 Asn-Pro-Ala signature motifs; other site 572477005547 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 572477005548 dimer interface [polypeptide binding]; other site 572477005549 putative radical transfer pathway; other site 572477005550 diiron center [ion binding]; other site 572477005551 tyrosyl radical; other site 572477005552 serine/threonine protein kinase; Provisional; Region: PRK11768 572477005553 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 572477005554 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 572477005555 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 572477005556 Colicin V production protein; Region: Colicin_V; cl00567 572477005557 Sporulation related domain; Region: SPOR; pfam05036 572477005558 Competence-damaged protein; Region: CinA; cl00666 572477005559 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 572477005560 Domain of unknown function DUF302; Region: DUF302; pfam03625 572477005561 Cysteine-rich small domain; Region: zf-like; cl00946 572477005562 pyruvate carboxylase subunit B; Validated; Region: PRK09282 572477005563 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 572477005564 active site 572477005565 catalytic residues [active] 572477005566 metal binding site [ion binding]; metal-binding site 572477005567 homodimer binding site [polypeptide binding]; other site 572477005568 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 572477005569 carboxyltransferase (CT) interaction site; other site 572477005570 biotinylation site [posttranslational modification]; other site 572477005571 pyruvate carboxylase subunit A; Validated; Region: PRK07178 572477005572 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 572477005573 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 572477005574 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 572477005575 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 572477005576 Sel1 repeat; Region: Sel1; cl02723 572477005577 Sel1-like repeats; Region: SEL1; smart00671 572477005578 Sel1 repeat; Region: Sel1; cl02723 572477005579 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 572477005580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572477005581 ATP-grasp domain; Region: ATP-grasp; pfam02222 572477005582 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 572477005583 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 572477005584 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 572477005585 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 572477005586 putative metal binding site [ion binding]; other site 572477005587 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 572477005588 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572477005589 ABC-ATPase subunit interface; other site 572477005590 dimer interface [polypeptide binding]; other site 572477005591 putative PBP binding regions; other site 572477005592 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 572477005593 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 572477005594 Walker A/P-loop; other site 572477005595 ATP binding site [chemical binding]; other site 572477005596 Q-loop/lid; other site 572477005597 ABC transporter signature motif; other site 572477005598 Walker B; other site 572477005599 D-loop; other site 572477005600 H-loop/switch region; other site 572477005601 Uncharacterized conserved protein [Function unknown]; Region: COG2014 572477005602 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 572477005603 Domain of unknown function (DUF364); Region: DUF364; pfam04016 572477005604 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 572477005605 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572477005606 Soluble P-type ATPase [General function prediction only]; Region: COG4087 572477005607 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 572477005608 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572477005609 putative NAD(P) binding site [chemical binding]; other site 572477005610 putative heme utilization carrier protein HutX; Region: HutX; TIGR04108 572477005611 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 572477005612 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477005613 FeS/SAM binding site; other site 572477005614 HemN C-terminal domain; Region: HemN_C; pfam06969 572477005615 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 572477005616 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 572477005617 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 572477005618 putative hemin binding site; other site 572477005619 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 572477005620 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572477005621 ABC-ATPase subunit interface; other site 572477005622 dimer interface [polypeptide binding]; other site 572477005623 putative PBP binding regions; other site 572477005624 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 572477005625 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 572477005626 Walker A/P-loop; other site 572477005627 ATP binding site [chemical binding]; other site 572477005628 Q-loop/lid; other site 572477005629 ABC transporter signature motif; other site 572477005630 Walker B; other site 572477005631 D-loop; other site 572477005632 H-loop/switch region; other site 572477005633 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 572477005634 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 572477005635 N-terminal plug; other site 572477005636 ligand-binding site [chemical binding]; other site 572477005637 Cytochrome c; Region: Cytochrom_C; cl11414 572477005638 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572477005639 active site 572477005640 DNA binding site [nucleotide binding] 572477005641 Int/Topo IB signature motif; other site 572477005642 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 572477005643 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 572477005644 Helix-turn-helix domain; Region: HTH_17; cl17695 572477005645 Helix-turn-helix domain; Region: HTH_17; pfam12728 572477005646 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 572477005647 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 572477005648 ssDNA binding site [nucleotide binding]; other site 572477005649 dimer interface [polypeptide binding]; other site 572477005650 tetramer (dimer of dimers) interface [polypeptide binding]; other site 572477005651 response regulator; Provisional; Region: PRK13435 572477005652 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 572477005653 Isochorismatase family; Region: Isochorismatase; pfam00857 572477005654 catalytic triad [active] 572477005655 dimer interface [polypeptide binding]; other site 572477005656 conserved cis-peptide bond; other site 572477005657 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 572477005658 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 572477005659 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 572477005660 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 572477005661 active site 572477005662 hydrophilic channel; other site 572477005663 dimerization interface [polypeptide binding]; other site 572477005664 catalytic residues [active] 572477005665 active site lid [active] 572477005666 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 572477005667 Recombination protein O N terminal; Region: RecO_N; pfam11967 572477005668 Recombination protein O C terminal; Region: RecO_C; pfam02565 572477005669 GTPase Era; Reviewed; Region: era; PRK00089 572477005670 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 572477005671 G1 box; other site 572477005672 GTP/Mg2+ binding site [chemical binding]; other site 572477005673 Switch I region; other site 572477005674 G2 box; other site 572477005675 Switch II region; other site 572477005676 G3 box; other site 572477005677 G4 box; other site 572477005678 G5 box; other site 572477005679 KH domain; Region: KH_2; pfam07650 572477005680 ribonuclease III; Reviewed; Region: rnc; PRK00102 572477005681 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 572477005682 dimerization interface [polypeptide binding]; other site 572477005683 active site 572477005684 metal binding site [ion binding]; metal-binding site 572477005685 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 572477005686 signal peptidase I; Provisional; Region: PRK10861 572477005687 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 572477005688 Catalytic site [active] 572477005689 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 572477005690 GTP-binding protein LepA; Provisional; Region: PRK05433 572477005691 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 572477005692 G1 box; other site 572477005693 putative GEF interaction site [polypeptide binding]; other site 572477005694 GTP/Mg2+ binding site [chemical binding]; other site 572477005695 Switch I region; other site 572477005696 G2 box; other site 572477005697 G3 box; other site 572477005698 Switch II region; other site 572477005699 G4 box; other site 572477005700 G5 box; other site 572477005701 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 572477005702 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 572477005703 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 572477005704 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 572477005705 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 572477005706 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 572477005707 protein binding site [polypeptide binding]; other site 572477005708 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 572477005709 protein binding site [polypeptide binding]; other site 572477005710 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 572477005711 anti-sigma E factor; Provisional; Region: rseB; PRK09455 572477005712 MucB/RseB family; Region: MucB_RseB; pfam03888 572477005713 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 572477005714 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 572477005715 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572477005716 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572477005717 DNA binding residues [nucleotide binding] 572477005718 L-aspartate oxidase; Provisional; Region: PRK09077 572477005719 L-aspartate oxidase; Provisional; Region: PRK06175 572477005720 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 572477005721 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 572477005722 CoA binding domain; Region: CoA_binding_2; pfam13380 572477005723 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 572477005724 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 572477005725 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572477005726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572477005727 Coenzyme A binding pocket [chemical binding]; other site 572477005728 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 572477005729 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 572477005730 putative active site [active] 572477005731 Zn binding site [ion binding]; other site 572477005732 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 572477005733 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572477005734 putative Zn2+ binding site [ion binding]; other site 572477005735 Integrase core domain; Region: rve; pfam00665 572477005736 Transposase; Region: HTH_Tnp_1; cl17663 572477005737 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 572477005738 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 572477005739 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 572477005740 aromatic arch; other site 572477005741 DCoH dimer interaction site [polypeptide binding]; other site 572477005742 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 572477005743 DCoH tetramer interaction site [polypeptide binding]; other site 572477005744 substrate binding site [chemical binding]; other site 572477005745 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 572477005746 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 572477005747 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 572477005748 switch II; other site 572477005749 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572477005750 Ferredoxin [Energy production and conversion]; Region: COG1146 572477005751 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572477005752 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 572477005753 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 572477005754 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 572477005755 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 572477005756 G1 box; other site 572477005757 GTP/Mg2+ binding site [chemical binding]; other site 572477005758 G2 box; other site 572477005759 Switch I region; other site 572477005760 G3 box; other site 572477005761 Switch II region; other site 572477005762 G4 box; other site 572477005763 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 572477005764 G1 box; other site 572477005765 GTP/Mg2+ binding site [chemical binding]; other site 572477005766 G2 box; other site 572477005767 Switch I region; other site 572477005768 G3 box; other site 572477005769 Switch II region; other site 572477005770 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 572477005771 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 572477005772 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 572477005773 PhoU domain; Region: PhoU; pfam01895 572477005774 Cache domain; Region: Cache_1; pfam02743 572477005775 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477005776 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477005777 dimerization interface [polypeptide binding]; other site 572477005778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477005779 dimer interface [polypeptide binding]; other site 572477005780 phosphorylation site [posttranslational modification] 572477005781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477005782 ATP binding site [chemical binding]; other site 572477005783 Mg2+ binding site [ion binding]; other site 572477005784 G-X-G motif; other site 572477005785 Response regulator receiver domain; Region: Response_reg; pfam00072 572477005786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477005787 active site 572477005788 phosphorylation site [posttranslational modification] 572477005789 intermolecular recognition site; other site 572477005790 dimerization interface [polypeptide binding]; other site 572477005791 Response regulator receiver domain; Region: Response_reg; pfam00072 572477005792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477005793 active site 572477005794 phosphorylation site [posttranslational modification] 572477005795 intermolecular recognition site; other site 572477005796 dimerization interface [polypeptide binding]; other site 572477005797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477005798 dimer interface [polypeptide binding]; other site 572477005799 phosphorylation site [posttranslational modification] 572477005800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477005801 ATP binding site [chemical binding]; other site 572477005802 Mg2+ binding site [ion binding]; other site 572477005803 G-X-G motif; other site 572477005804 Response regulator receiver domain; Region: Response_reg; pfam00072 572477005805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477005806 active site 572477005807 phosphorylation site [posttranslational modification] 572477005808 intermolecular recognition site; other site 572477005809 dimerization interface [polypeptide binding]; other site 572477005810 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 572477005811 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 572477005812 active site 572477005813 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 572477005814 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 572477005815 motif 1; other site 572477005816 dimer interface [polypeptide binding]; other site 572477005817 active site 572477005818 motif 2; other site 572477005819 motif 3; other site 572477005820 elongation factor P; Validated; Region: PRK00529 572477005821 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 572477005822 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 572477005823 RNA binding site [nucleotide binding]; other site 572477005824 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 572477005825 RNA binding site [nucleotide binding]; other site 572477005826 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 572477005827 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 572477005828 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 572477005829 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477005830 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 572477005831 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 572477005832 N-acetyl-D-glucosamine binding site [chemical binding]; other site 572477005833 catalytic residue [active] 572477005834 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 572477005835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477005836 Walker A motif; other site 572477005837 ATP binding site [chemical binding]; other site 572477005838 Walker B motif; other site 572477005839 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 572477005840 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 572477005841 ligand binding site [chemical binding]; other site 572477005842 Uncharacterized conserved protein (DUF2365); Region: DUF2365; pfam10157 572477005843 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 572477005844 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572477005845 Magnesium ion binding site [ion binding]; other site 572477005846 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 572477005847 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 572477005848 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 572477005849 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 572477005850 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 572477005851 tetramer interfaces [polypeptide binding]; other site 572477005852 binuclear metal-binding site [ion binding]; other site 572477005853 thiamine monophosphate kinase; Provisional; Region: PRK05731 572477005854 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 572477005855 ATP binding site [chemical binding]; other site 572477005856 dimerization interface [polypeptide binding]; other site 572477005857 transcription antitermination factor NusB; Region: nusB; TIGR01951 572477005858 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 572477005859 homopentamer interface [polypeptide binding]; other site 572477005860 active site 572477005861 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 572477005862 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 572477005863 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 572477005864 dimerization interface [polypeptide binding]; other site 572477005865 active site 572477005866 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 572477005867 Lumazine binding domain; Region: Lum_binding; pfam00677 572477005868 Lumazine binding domain; Region: Lum_binding; pfam00677 572477005869 Response regulator receiver domain; Region: Response_reg; pfam00072 572477005870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477005871 active site 572477005872 phosphorylation site [posttranslational modification] 572477005873 intermolecular recognition site; other site 572477005874 dimerization interface [polypeptide binding]; other site 572477005875 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 572477005876 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 572477005877 catalytic motif [active] 572477005878 Zn binding site [ion binding]; other site 572477005879 RibD C-terminal domain; Region: RibD_C; cl17279 572477005880 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 572477005881 ATP cone domain; Region: ATP-cone; pfam03477 572477005882 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 572477005883 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 572477005884 dimer interface [polypeptide binding]; other site 572477005885 active site 572477005886 glycine-pyridoxal phosphate binding site [chemical binding]; other site 572477005887 folate binding site [chemical binding]; other site 572477005888 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572477005889 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 572477005890 catalytic site [active] 572477005891 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 572477005892 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 572477005893 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572477005894 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 572477005895 dimerization interface [polypeptide binding]; other site 572477005896 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 572477005897 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 572477005898 active site 572477005899 dimer interface [polypeptide binding]; other site 572477005900 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 572477005901 Ligand Binding Site [chemical binding]; other site 572477005902 Molecular Tunnel; other site 572477005903 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 572477005904 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 572477005905 putative ADP-binding pocket [chemical binding]; other site 572477005906 exosortase A; Region: exosortase_1; TIGR03109 572477005907 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 572477005908 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 572477005909 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 572477005910 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 572477005911 FemAB-related protein, PEP-CTERM system-associated; Region: pepcterm_femAB; TIGR03019 572477005912 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 572477005913 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 572477005914 putative active site [active] 572477005915 putative catalytic site [active] 572477005916 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 572477005917 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 572477005918 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572477005919 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 572477005920 Chain length determinant protein; Region: Wzz; cl15801 572477005921 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 572477005922 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 572477005923 SLBB domain; Region: SLBB; pfam10531 572477005924 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 572477005925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477005926 active site 572477005927 phosphorylation site [posttranslational modification] 572477005928 intermolecular recognition site; other site 572477005929 dimerization interface [polypeptide binding]; other site 572477005930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477005931 Walker A motif; other site 572477005932 ATP binding site [chemical binding]; other site 572477005933 Walker B motif; other site 572477005934 arginine finger; other site 572477005935 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 572477005936 GAF domain; Region: GAF_3; pfam13492 572477005937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477005938 dimer interface [polypeptide binding]; other site 572477005939 phosphorylation site [posttranslational modification] 572477005940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477005941 ATP binding site [chemical binding]; other site 572477005942 Mg2+ binding site [ion binding]; other site 572477005943 G-X-G motif; other site 572477005944 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572477005945 Methyltransferase domain; Region: Methyltransf_11; pfam08241 572477005946 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 572477005947 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 572477005948 Glycosyl hydrolase family 47; Region: Glyco_hydro_47; cl08327 572477005949 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 572477005950 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 572477005951 inhibitor-cofactor binding pocket; inhibition site 572477005952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477005953 catalytic residue [active] 572477005954 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572477005955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477005956 S-adenosylmethionine binding site [chemical binding]; other site 572477005957 GtrA-like protein; Region: GtrA; pfam04138 572477005958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572477005959 Coenzyme A binding pocket [chemical binding]; other site 572477005960 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 572477005961 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 572477005962 Ligand binding site; other site 572477005963 Putative Catalytic site; other site 572477005964 DXD motif; other site 572477005965 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 572477005966 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 572477005967 colanic acid exporter; Provisional; Region: PRK10459 572477005968 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 572477005969 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 572477005970 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572477005971 Winged helix-turn helix; Region: HTH_29; pfam13551 572477005972 Integrase core domain; Region: rve; pfam00665 572477005973 Integrase core domain; Region: rve_3; pfam13683 572477005974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477005975 TPR motif; other site 572477005976 binding surface 572477005977 TPR repeat; Region: TPR_11; pfam13414 572477005978 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 572477005979 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 572477005980 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 572477005981 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 572477005982 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 572477005983 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572477005984 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 572477005985 acyl-activating enzyme (AAE) consensus motif; other site 572477005986 acyl-activating enzyme (AAE) consensus motif; other site 572477005987 putative AMP binding site [chemical binding]; other site 572477005988 putative active site [active] 572477005989 putative CoA binding site [chemical binding]; other site 572477005990 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 572477005991 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 572477005992 dimer interface [polypeptide binding]; other site 572477005993 active site 572477005994 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572477005995 catalytic residues [active] 572477005996 substrate binding site [chemical binding]; other site 572477005997 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 572477005998 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 572477005999 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 572477006000 Ligand Binding Site [chemical binding]; other site 572477006001 Molecular Tunnel; other site 572477006002 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 572477006003 Sel1-like repeats; Region: SEL1; smart00671 572477006004 Sel1-like repeats; Region: SEL1; smart00671 572477006005 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 572477006006 active site 572477006007 putative homodimer interface [polypeptide binding]; other site 572477006008 SAM binding site [chemical binding]; other site 572477006009 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 572477006010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477006011 S-adenosylmethionine binding site [chemical binding]; other site 572477006012 Cache domain; Region: Cache_1; pfam02743 572477006013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 572477006014 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477006015 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477006016 metal binding site [ion binding]; metal-binding site 572477006017 active site 572477006018 I-site; other site 572477006019 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 572477006020 metal-binding site [ion binding] 572477006021 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 572477006022 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 572477006023 metal-binding site [ion binding] 572477006024 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572477006025 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572477006026 motif II; other site 572477006027 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 572477006028 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 572477006029 catalytic triad [active] 572477006030 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 572477006031 Domain of unknown function DUF21; Region: DUF21; pfam01595 572477006032 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 572477006033 Transporter associated domain; Region: CorC_HlyC; smart01091 572477006034 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 572477006035 Domain of unknown function DUF21; Region: DUF21; pfam01595 572477006036 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 572477006037 Transporter associated domain; Region: CorC_HlyC; pfam03471 572477006038 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 572477006039 Nuclease-related domain; Region: NERD; pfam08378 572477006040 Predicted periplasmic protein [Function unknown]; Region: COG3698 572477006041 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 572477006042 Fic family protein [Function unknown]; Region: COG3177 572477006043 Fic/DOC family; Region: Fic; pfam02661 572477006044 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 572477006045 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 572477006046 Walker A/P-loop; other site 572477006047 ATP binding site [chemical binding]; other site 572477006048 Q-loop/lid; other site 572477006049 ABC transporter signature motif; other site 572477006050 Walker B; other site 572477006051 D-loop; other site 572477006052 H-loop/switch region; other site 572477006053 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 572477006054 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572477006055 ABC-ATPase subunit interface; other site 572477006056 dimer interface [polypeptide binding]; other site 572477006057 putative PBP binding regions; other site 572477006058 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 572477006059 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 572477006060 intersubunit interface [polypeptide binding]; other site 572477006061 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 572477006062 homotrimer interface [polypeptide binding]; other site 572477006063 Walker A motif; other site 572477006064 GTP binding site [chemical binding]; other site 572477006065 Walker B motif; other site 572477006066 alanine racemase; Reviewed; Region: alr; PRK00053 572477006067 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 572477006068 active site 572477006069 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572477006070 substrate binding site [chemical binding]; other site 572477006071 catalytic residues [active] 572477006072 dimer interface [polypeptide binding]; other site 572477006073 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 572477006074 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 572477006075 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 572477006076 Uncharacterized conserved protein [Function unknown]; Region: COG1565 572477006077 Dihydroneopterin aldolase; Region: FolB; smart00905 572477006078 active site 572477006079 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 572477006080 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572477006081 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 572477006082 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 572477006083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477006084 dimer interface [polypeptide binding]; other site 572477006085 phosphorylation site [posttranslational modification] 572477006086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477006087 ATP binding site [chemical binding]; other site 572477006088 Mg2+ binding site [ion binding]; other site 572477006089 G-X-G motif; other site 572477006090 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 572477006091 UGMP family protein; Validated; Region: PRK09604 572477006092 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 572477006093 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 572477006094 Yqey-like protein; Region: YqeY; pfam09424 572477006095 DNA primase; Validated; Region: dnaG; PRK05667 572477006096 CHC2 zinc finger; Region: zf-CHC2; pfam01807 572477006097 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 572477006098 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 572477006099 active site 572477006100 metal binding site [ion binding]; metal-binding site 572477006101 interdomain interaction site; other site 572477006102 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 572477006103 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 572477006104 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 572477006105 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 572477006106 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 572477006107 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 572477006108 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572477006109 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 572477006110 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572477006111 DNA binding residues [nucleotide binding] 572477006112 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572477006113 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 572477006114 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 572477006115 Walker A/P-loop; other site 572477006116 ATP binding site [chemical binding]; other site 572477006117 Q-loop/lid; other site 572477006118 ABC transporter signature motif; other site 572477006119 Walker B; other site 572477006120 D-loop; other site 572477006121 H-loop/switch region; other site 572477006122 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 572477006123 Predicted transcriptional regulator [Transcription]; Region: COG2932 572477006124 Catalytic site [active] 572477006125 Cytochrome c; Region: Cytochrom_C; cl11414 572477006126 Cytochrome c; Region: Cytochrom_C; cl11414 572477006127 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 572477006128 ATP cone domain; Region: ATP-cone; pfam03477 572477006129 Class I ribonucleotide reductase; Region: RNR_I; cd01679 572477006130 active site 572477006131 dimer interface [polypeptide binding]; other site 572477006132 catalytic residues [active] 572477006133 effector binding site; other site 572477006134 R2 peptide binding site; other site 572477006135 isocitrate lyase; Provisional; Region: PRK15063 572477006136 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 572477006137 tetramer interface [polypeptide binding]; other site 572477006138 active site 572477006139 Mg2+/Mn2+ binding site [ion binding]; other site 572477006140 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 572477006141 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 572477006142 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 572477006143 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 572477006144 dihydrodipicolinate reductase; Provisional; Region: PRK00048 572477006145 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 572477006146 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 572477006147 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 572477006148 Protein export membrane protein; Region: SecD_SecF; cl14618 572477006149 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 572477006150 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 572477006151 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 572477006152 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 572477006153 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 572477006154 acyl-activating enzyme (AAE) consensus motif; other site 572477006155 putative AMP binding site [chemical binding]; other site 572477006156 putative active site [active] 572477006157 putative CoA binding site [chemical binding]; other site 572477006158 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 572477006159 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 572477006160 minor groove reading motif; other site 572477006161 helix-hairpin-helix signature motif; other site 572477006162 substrate binding pocket [chemical binding]; other site 572477006163 active site 572477006164 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 572477006165 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 572477006166 DNA binding and oxoG recognition site [nucleotide binding] 572477006167 oxidative damage protection protein; Provisional; Region: PRK05408 572477006168 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 572477006169 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 572477006170 ligand binding site; other site 572477006171 oligomer interface; other site 572477006172 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 572477006173 dimer interface [polypeptide binding]; other site 572477006174 N-terminal domain interface [polypeptide binding]; other site 572477006175 sulfate 1 binding site; other site 572477006176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 572477006177 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572477006178 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477006179 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477006180 metal binding site [ion binding]; metal-binding site 572477006181 active site 572477006182 I-site; other site 572477006183 Bacterial PH domain; Region: DUF304; pfam03703 572477006184 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 572477006185 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 572477006186 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 572477006187 bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571 572477006188 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 572477006189 putative dimer interface [polypeptide binding]; other site 572477006190 [2Fe-2S] cluster binding site [ion binding]; other site 572477006191 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 572477006192 dimer interface [polypeptide binding]; other site 572477006193 [2Fe-2S] cluster binding site [ion binding]; other site 572477006194 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 572477006195 SLBB domain; Region: SLBB; pfam10531 572477006196 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 572477006197 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 572477006198 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572477006199 catalytic loop [active] 572477006200 iron binding site [ion binding]; other site 572477006201 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 572477006202 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 572477006203 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 572477006204 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 572477006205 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 572477006206 nickel binding site [ion binding]; other site 572477006207 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 572477006208 Predicted ATPase [General function prediction only]; Region: COG4637 572477006209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 572477006210 Walker B; other site 572477006211 D-loop; other site 572477006212 H-loop/switch region; other site 572477006213 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 572477006214 putative active site [active] 572477006215 putative metal-binding site [ion binding]; other site 572477006216 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477006217 dimerization interface [polypeptide binding]; other site 572477006218 PAS domain; Region: PAS_9; pfam13426 572477006219 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477006220 dimer interface [polypeptide binding]; other site 572477006221 putative CheW interface [polypeptide binding]; other site 572477006222 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 572477006223 PAS domain S-box; Region: sensory_box; TIGR00229 572477006224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477006225 putative active site [active] 572477006226 heme pocket [chemical binding]; other site 572477006227 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477006228 dimer interface [polypeptide binding]; other site 572477006229 phosphorylation site [posttranslational modification] 572477006230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477006231 ATP binding site [chemical binding]; other site 572477006232 Mg2+ binding site [ion binding]; other site 572477006233 G-X-G motif; other site 572477006234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477006235 active site 572477006236 phosphorylation site [posttranslational modification] 572477006237 intermolecular recognition site; other site 572477006238 dimerization interface [polypeptide binding]; other site 572477006239 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 572477006240 archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700 572477006241 NifT/FixU protein; Region: NifT; pfam06988 572477006242 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 572477006243 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 572477006244 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 572477006245 MoFe protein beta/alpha subunit interactions; other site 572477006246 Beta subunit P cluster binding residues; other site 572477006247 MoFe protein beta subunit/Fe protein contacts; other site 572477006248 MoFe protein dimer/ dimer interactions; other site 572477006249 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 572477006250 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 572477006251 MoFe protein alpha/beta subunit interactions; other site 572477006252 Alpha subunit P cluster binding residues; other site 572477006253 FeMoco binding residues [chemical binding]; other site 572477006254 MoFe protein alpha subunit/Fe protein contacts; other site 572477006255 MoFe protein dimer/ dimer interactions; other site 572477006256 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 572477006257 nitrogenase iron protein; Region: nifH; TIGR01287 572477006258 Nucleotide-binding sites [chemical binding]; other site 572477006259 Walker A motif; other site 572477006260 Switch I region of nucleotide binding site; other site 572477006261 Fe4S4 binding sites [ion binding]; other site 572477006262 Switch II region of nucleotide binding site; other site 572477006263 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 572477006264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477006265 dimerization interface [polypeptide binding]; other site 572477006266 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572477006267 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477006268 dimer interface [polypeptide binding]; other site 572477006269 putative CheW interface [polypeptide binding]; other site 572477006270 PilZ domain; Region: PilZ; cl01260 572477006271 DNA polymerase III subunit delta'; Validated; Region: PRK05707 572477006272 DNA polymerase III subunit delta'; Validated; Region: PRK08485 572477006273 thymidylate kinase; Validated; Region: tmk; PRK00698 572477006274 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 572477006275 TMP-binding site; other site 572477006276 ATP-binding site [chemical binding]; other site 572477006277 YceG-like family; Region: YceG; pfam02618 572477006278 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 572477006279 dimerization interface [polypeptide binding]; other site 572477006280 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 572477006281 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 572477006282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477006283 catalytic residue [active] 572477006284 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 572477006285 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 572477006286 dimer interface [polypeptide binding]; other site 572477006287 active site 572477006288 acyl carrier protein; Provisional; Region: acpP; PRK00982 572477006289 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 572477006290 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 572477006291 NAD(P) binding site [chemical binding]; other site 572477006292 homotetramer interface [polypeptide binding]; other site 572477006293 homodimer interface [polypeptide binding]; other site 572477006294 active site 572477006295 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 572477006296 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 572477006297 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 572477006298 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 572477006299 dimer interface [polypeptide binding]; other site 572477006300 active site 572477006301 CoA binding pocket [chemical binding]; other site 572477006302 putative phosphate acyltransferase; Provisional; Region: PRK05331 572477006303 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 572477006304 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 572477006305 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 572477006306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477006307 active site 572477006308 phosphorylation site [posttranslational modification] 572477006309 intermolecular recognition site; other site 572477006310 dimerization interface [polypeptide binding]; other site 572477006311 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572477006312 DNA binding residues [nucleotide binding] 572477006313 dimerization interface [polypeptide binding]; other site 572477006314 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 572477006315 catalytic center binding site [active] 572477006316 ATP binding site [chemical binding]; other site 572477006317 Oxygen tolerance; Region: BatD; pfam13584 572477006318 von Willebrand factor type A domain; Region: VWA_2; pfam13519 572477006319 metal ion-dependent adhesion site (MIDAS); other site 572477006320 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 572477006321 metal ion-dependent adhesion site (MIDAS); other site 572477006322 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 572477006323 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 572477006324 Protein of unknown function DUF58; Region: DUF58; pfam01882 572477006325 MoxR-like ATPases [General function prediction only]; Region: COG0714 572477006326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477006327 Walker A motif; other site 572477006328 ATP binding site [chemical binding]; other site 572477006329 Walker B motif; other site 572477006330 arginine finger; other site 572477006331 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 572477006332 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 572477006333 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 572477006334 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 572477006335 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 572477006336 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 572477006337 carboxyltransferase (CT) interaction site; other site 572477006338 biotinylation site [posttranslational modification]; other site 572477006339 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 572477006340 Dehydroquinase class II; Region: DHquinase_II; pfam01220 572477006341 active site 572477006342 trimer interface [polypeptide binding]; other site 572477006343 dimer interface [polypeptide binding]; other site 572477006344 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 572477006345 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 572477006346 catalytic residues [active] 572477006347 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 572477006348 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 572477006349 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 572477006350 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 572477006351 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 572477006352 DsbD alpha interface [polypeptide binding]; other site 572477006353 catalytic residues [active] 572477006354 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 572477006355 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 572477006356 PilZ domain; Region: PilZ; pfam07238 572477006357 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 572477006358 HSP70 interaction site [polypeptide binding]; other site 572477006359 VacJ like lipoprotein; Region: VacJ; cl01073 572477006360 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 572477006361 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 572477006362 dimer interface [polypeptide binding]; other site 572477006363 catalytic site [active] 572477006364 putative active site [active] 572477006365 putative substrate binding site [chemical binding]; other site 572477006366 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 572477006367 putative GSH binding site [chemical binding]; other site 572477006368 catalytic residues [active] 572477006369 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 572477006370 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 572477006371 active site 572477006372 dimer interface [polypeptide binding]; other site 572477006373 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 572477006374 Ligand Binding Site [chemical binding]; other site 572477006375 Molecular Tunnel; other site 572477006376 superoxide dismutase; Provisional; Region: PRK10543 572477006377 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 572477006378 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 572477006379 acetylornithine aminotransferase; Provisional; Region: PRK02627 572477006380 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572477006381 inhibitor-cofactor binding pocket; inhibition site 572477006382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477006383 catalytic residue [active] 572477006384 ornithine carbamoyltransferase; Provisional; Region: PRK00779 572477006385 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 572477006386 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 572477006387 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 572477006388 nudix motif; other site 572477006389 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 572477006390 putative hexamer interface [polypeptide binding]; other site 572477006391 putative hexagonal pore; other site 572477006392 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 572477006393 putative hexamer interface [polypeptide binding]; other site 572477006394 putative hexagonal pore; other site 572477006395 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 572477006396 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 572477006397 MPT binding site; other site 572477006398 trimer interface [polypeptide binding]; other site 572477006399 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 572477006400 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 572477006401 dimer interface [polypeptide binding]; other site 572477006402 putative functional site; other site 572477006403 putative MPT binding site; other site 572477006404 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 572477006405 MoaE interaction surface [polypeptide binding]; other site 572477006406 MoeB interaction surface [polypeptide binding]; other site 572477006407 thiocarboxylated glycine; other site 572477006408 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 572477006409 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 572477006410 FAD binding domain; Region: FAD_binding_4; pfam01565 572477006411 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 572477006412 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 572477006413 substrate binding site; other site 572477006414 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 572477006415 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 572477006416 NAD binding site [chemical binding]; other site 572477006417 homotetramer interface [polypeptide binding]; other site 572477006418 homodimer interface [polypeptide binding]; other site 572477006419 substrate binding site [chemical binding]; other site 572477006420 active site 572477006421 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 572477006422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572477006423 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 572477006424 NAD(P) binding site [chemical binding]; other site 572477006425 active site 572477006426 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 572477006427 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477006428 FeS/SAM binding site; other site 572477006429 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 572477006430 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477006431 FeS/SAM binding site; other site 572477006432 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 572477006433 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572477006434 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477006435 Radical SAM superfamily; Region: Radical_SAM; pfam04055 572477006436 FeS/SAM binding site; other site 572477006437 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 572477006438 classical (c) SDRs; Region: SDR_c; cd05233 572477006439 NAD(P) binding site [chemical binding]; other site 572477006440 active site 572477006441 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 572477006442 B12 binding domain; Region: B12-binding; pfam02310 572477006443 B12 binding site [chemical binding]; other site 572477006444 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 572477006445 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572477006446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477006447 S-adenosylmethionine binding site [chemical binding]; other site 572477006448 Cephalosporin hydroxylase; Region: CmcI; pfam04989 572477006449 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477006450 TPR repeat; Region: TPR_11; pfam13414 572477006451 binding surface 572477006452 TPR motif; other site 572477006453 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 572477006454 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477006455 binding surface 572477006456 TPR motif; other site 572477006457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477006458 binding surface 572477006459 TPR motif; other site 572477006460 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 572477006461 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477006462 binding surface 572477006463 TPR motif; other site 572477006464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477006465 TPR motif; other site 572477006466 binding surface 572477006467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477006468 binding surface 572477006469 TPR motif; other site 572477006470 TPR repeat; Region: TPR_11; pfam13414 572477006471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477006472 binding surface 572477006473 TPR repeat; Region: TPR_11; pfam13414 572477006474 TPR motif; other site 572477006475 Tetratricopeptide repeat; Region: TPR_16; pfam13432 572477006476 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477006477 binding surface 572477006478 TPR motif; other site 572477006479 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572477006480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477006481 S-adenosylmethionine binding site [chemical binding]; other site 572477006482 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 572477006483 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 572477006484 FlaG protein; Region: FlaG; pfam03646 572477006485 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 572477006486 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 572477006487 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 572477006488 flagellar protein FliS; Validated; Region: fliS; PRK05685 572477006489 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 572477006490 phosphoserine aminotransferase; Provisional; Region: PRK12462 572477006491 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572477006492 catalytic residue [active] 572477006493 methionine sulfoxide reductase A; Provisional; Region: PRK14054 572477006494 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 572477006495 Acylphosphatase; Region: Acylphosphatase; pfam00708 572477006496 HypF finger; Region: zf-HYPF; pfam07503 572477006497 HypF finger; Region: zf-HYPF; pfam07503 572477006498 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 572477006499 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572477006500 sequence-specific DNA binding site [nucleotide binding]; other site 572477006501 salt bridge; other site 572477006502 Hemerythrin; Region: Hemerythrin; cd12107 572477006503 Fe binding site [ion binding]; other site 572477006504 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 572477006505 L-aspartate oxidase; Provisional; Region: PRK06175 572477006506 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 572477006507 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 572477006508 SdhC subunit interface [polypeptide binding]; other site 572477006509 proximal heme binding site [chemical binding]; other site 572477006510 cardiolipin binding site; other site 572477006511 Iron-sulfur protein interface; other site 572477006512 proximal quinone binding site [chemical binding]; other site 572477006513 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 572477006514 Iron-sulfur protein interface; other site 572477006515 proximal quinone binding site [chemical binding]; other site 572477006516 SdhD (CybS) interface [polypeptide binding]; other site 572477006517 proximal heme binding site [chemical binding]; other site 572477006518 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 572477006519 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 572477006520 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 572477006521 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 572477006522 NAD binding site [chemical binding]; other site 572477006523 homodimer interface [polypeptide binding]; other site 572477006524 active site 572477006525 substrate binding site [chemical binding]; other site 572477006526 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 572477006527 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572477006528 NAD binding site [chemical binding]; other site 572477006529 putative substrate binding site 2 [chemical binding]; other site 572477006530 putative substrate binding site 1 [chemical binding]; other site 572477006531 active site 572477006532 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 572477006533 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 572477006534 active site 572477006535 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 572477006536 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 572477006537 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 572477006538 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 572477006539 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477006540 FeS/SAM binding site; other site 572477006541 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 572477006542 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477006543 FeS/SAM binding site; other site 572477006544 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 572477006545 EamA-like transporter family; Region: EamA; pfam00892 572477006546 EamA-like transporter family; Region: EamA; pfam00892 572477006547 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572477006548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477006549 S-adenosylmethionine binding site [chemical binding]; other site 572477006550 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572477006551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477006552 S-adenosylmethionine binding site [chemical binding]; other site 572477006553 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 572477006554 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572477006555 Zn2+ binding site [ion binding]; other site 572477006556 Mg2+ binding site [ion binding]; other site 572477006557 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 572477006558 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572477006559 active site 572477006560 HIGH motif; other site 572477006561 nucleotide binding site [chemical binding]; other site 572477006562 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 572477006563 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 572477006564 active site 572477006565 KMSKS motif; other site 572477006566 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 572477006567 tRNA binding surface [nucleotide binding]; other site 572477006568 anticodon binding site; other site 572477006569 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 572477006570 lipoprotein signal peptidase; Provisional; Region: PRK14787 572477006571 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 572477006572 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 572477006573 RimK-like ATP-grasp domain; Region: RimK; pfam08443 572477006574 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 572477006575 catalytic motif [active] 572477006576 Catalytic residue [active] 572477006577 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 572477006578 transmembrane helices; other site 572477006579 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 572477006580 TrkA-C domain; Region: TrkA_C; pfam02080 572477006581 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 572477006582 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 572477006583 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572477006584 ATP binding site [chemical binding]; other site 572477006585 putative Mg++ binding site [ion binding]; other site 572477006586 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572477006587 nucleotide binding region [chemical binding]; other site 572477006588 ATP-binding site [chemical binding]; other site 572477006589 Helicase associated domain (HA2); Region: HA2; pfam04408 572477006590 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 572477006591 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 572477006592 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477006593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477006594 active site 572477006595 phosphorylation site [posttranslational modification] 572477006596 intermolecular recognition site; other site 572477006597 Response regulator receiver domain; Region: Response_reg; pfam00072 572477006598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477006599 active site 572477006600 phosphorylation site [posttranslational modification] 572477006601 intermolecular recognition site; other site 572477006602 dimerization interface [polypeptide binding]; other site 572477006603 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477006604 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477006605 metal binding site [ion binding]; metal-binding site 572477006606 active site 572477006607 I-site; other site 572477006608 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 572477006609 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 572477006610 inhibitor-cofactor binding pocket; inhibition site 572477006611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477006612 catalytic residue [active] 572477006613 META domain; Region: META; pfam03724 572477006614 META domain; Region: META; pfam03724 572477006615 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 572477006616 homodimer interface [polypeptide binding]; other site 572477006617 substrate-cofactor binding pocket; other site 572477006618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477006619 catalytic residue [active] 572477006620 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 572477006621 CAP-like domain; other site 572477006622 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 572477006623 protein-splicing catalytic site; other site 572477006624 thioester formation/cholesterol transfer; other site 572477006625 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 572477006626 DNA gyrase subunit A; Validated; Region: PRK05560 572477006627 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 572477006628 active site 572477006629 primary dimer interface [polypeptide binding]; other site 572477006630 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572477006631 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572477006632 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572477006633 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572477006634 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572477006635 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572477006636 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477006637 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 572477006638 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 572477006639 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 572477006640 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 572477006641 active site 572477006642 putative substrate binding pocket [chemical binding]; other site 572477006643 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572477006644 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 572477006645 catalytic loop [active] 572477006646 iron binding site [ion binding]; other site 572477006647 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 572477006648 FAD binding pocket [chemical binding]; other site 572477006649 conserved FAD binding motif [chemical binding]; other site 572477006650 phosphate binding motif [ion binding]; other site 572477006651 beta-alpha-beta structure motif; other site 572477006652 NAD binding pocket [chemical binding]; other site 572477006653 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 572477006654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477006655 S-adenosylmethionine binding site [chemical binding]; other site 572477006656 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 572477006657 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572477006658 Walker A motif; other site 572477006659 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 572477006660 protein-splicing catalytic site; other site 572477006661 thioester formation/cholesterol transfer; other site 572477006662 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 572477006663 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 572477006664 protein-splicing catalytic site; other site 572477006665 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 572477006666 Walker B motif; other site 572477006667 DNA binding loops [nucleotide binding] 572477006668 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 572477006669 protein-splicing catalytic site; other site 572477006670 thioester formation/cholesterol transfer; other site 572477006671 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 572477006672 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 572477006673 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572477006674 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 572477006675 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 572477006676 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 572477006677 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 572477006678 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 572477006679 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572477006680 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572477006681 ligand binding site [chemical binding]; other site 572477006682 flexible hinge region; other site 572477006683 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 572477006684 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 572477006685 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 572477006686 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 572477006687 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 572477006688 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 572477006689 putative active site [active] 572477006690 PhoH-like protein; Region: PhoH; pfam02562 572477006691 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572477006692 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 572477006693 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 572477006694 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 572477006695 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 572477006696 nudix motif; other site 572477006697 PEP synthetase regulatory protein; Provisional; Region: PRK05339 572477006698 Chain length determinant protein; Region: Wzz; cl15801 572477006699 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 572477006700 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 572477006701 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 572477006702 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 572477006703 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 572477006704 TRAM domain; Region: TRAM; cl01282 572477006705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477006706 S-adenosylmethionine binding site [chemical binding]; other site 572477006707 Cupin domain; Region: Cupin_2; cl17218 572477006708 Transposase IS200 like; Region: Y1_Tnp; pfam01797 572477006709 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572477006710 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 572477006711 ATP binding site [chemical binding]; other site 572477006712 putative Mg++ binding site [ion binding]; other site 572477006713 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572477006714 nucleotide binding region [chemical binding]; other site 572477006715 ATP-binding site [chemical binding]; other site 572477006716 Helicase associated domain (HA2); Region: HA2; pfam04408 572477006717 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 572477006718 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 572477006719 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 572477006720 active site 572477006721 zinc binding site [ion binding]; other site 572477006722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477006723 S-adenosylmethionine binding site [chemical binding]; other site 572477006724 4-alpha-glucanotransferase; Provisional; Region: PRK14508 572477006725 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 572477006726 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 572477006727 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572477006728 putative active site [active] 572477006729 putative metal binding site [ion binding]; other site 572477006730 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 572477006731 Protein phosphatase 2C; Region: PP2C_2; pfam13672 572477006732 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 572477006733 metal ion-dependent adhesion site (MIDAS); other site 572477006734 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 572477006735 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 572477006736 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 572477006737 homodimer interface [polypeptide binding]; other site 572477006738 NADP binding site [chemical binding]; other site 572477006739 substrate binding site [chemical binding]; other site 572477006740 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 572477006741 catalytic residues [active] 572477006742 dimer interface [polypeptide binding]; other site 572477006743 ferredoxin-NADP reductase; Provisional; Region: PRK10926 572477006744 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 572477006745 FAD binding pocket [chemical binding]; other site 572477006746 FAD binding motif [chemical binding]; other site 572477006747 phosphate binding motif [ion binding]; other site 572477006748 beta-alpha-beta structure motif; other site 572477006749 NAD binding pocket [chemical binding]; other site 572477006750 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 572477006751 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 572477006752 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 572477006753 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 572477006754 Cysteine-rich domain; Region: CCG; pfam02754 572477006755 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 572477006756 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 572477006757 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 572477006758 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 572477006759 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 572477006760 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 572477006761 metal binding triad; other site 572477006762 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 572477006763 HD domain; Region: HD; pfam01966 572477006764 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 572477006765 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 572477006766 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 572477006767 active site 572477006768 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 572477006769 rRNA interaction site [nucleotide binding]; other site 572477006770 S8 interaction site; other site 572477006771 putative laminin-1 binding site; other site 572477006772 elongation factor Ts; Provisional; Region: tsf; PRK09377 572477006773 UBA/TS-N domain; Region: UBA; pfam00627 572477006774 Elongation factor TS; Region: EF_TS; pfam00889 572477006775 Elongation factor TS; Region: EF_TS; pfam00889 572477006776 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 572477006777 putative nucleotide binding site [chemical binding]; other site 572477006778 uridine monophosphate binding site [chemical binding]; other site 572477006779 homohexameric interface [polypeptide binding]; other site 572477006780 ribosome recycling factor; Reviewed; Region: frr; PRK00083 572477006781 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 572477006782 hinge region; other site 572477006783 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 572477006784 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 572477006785 catalytic residue [active] 572477006786 putative FPP diphosphate binding site; other site 572477006787 putative FPP binding hydrophobic cleft; other site 572477006788 dimer interface [polypeptide binding]; other site 572477006789 putative IPP diphosphate binding site; other site 572477006790 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 572477006791 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 572477006792 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 572477006793 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 572477006794 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 572477006795 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 572477006796 zinc metallopeptidase RseP; Provisional; Region: PRK10779 572477006797 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 572477006798 active site 572477006799 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 572477006800 protein binding site [polypeptide binding]; other site 572477006801 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 572477006802 protein binding site [polypeptide binding]; other site 572477006803 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 572477006804 putative substrate binding region [chemical binding]; other site 572477006805 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 572477006806 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 572477006807 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 572477006808 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 572477006809 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 572477006810 Surface antigen; Region: Bac_surface_Ag; pfam01103 572477006811 periplasmic chaperone; Provisional; Region: PRK10780 572477006812 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 572477006813 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 572477006814 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 572477006815 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 572477006816 trimer interface [polypeptide binding]; other site 572477006817 active site 572477006818 UDP-GlcNAc binding site [chemical binding]; other site 572477006819 lipid binding site [chemical binding]; lipid-binding site 572477006820 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 572477006821 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 572477006822 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 572477006823 active site 572477006824 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 572477006825 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 572477006826 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 572477006827 RNA/DNA hybrid binding site [nucleotide binding]; other site 572477006828 active site 572477006829 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 572477006830 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 572477006831 dimer interface [polypeptide binding]; other site 572477006832 active site 572477006833 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572477006834 catalytic residues [active] 572477006835 substrate binding site [chemical binding]; other site 572477006836 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 572477006837 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 572477006838 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 572477006839 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 572477006840 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572477006841 catalytic residue [active] 572477006842 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 572477006843 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 572477006844 putative catalytic site [active] 572477006845 putative phosphate binding site [ion binding]; other site 572477006846 active site 572477006847 metal binding site A [ion binding]; metal-binding site 572477006848 DNA binding site [nucleotide binding] 572477006849 putative AP binding site [nucleotide binding]; other site 572477006850 putative metal binding site B [ion binding]; other site 572477006851 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 572477006852 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 572477006853 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 572477006854 catalytic residues [active] 572477006855 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 572477006856 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 572477006857 putative RNA binding site [nucleotide binding]; other site 572477006858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477006859 S-adenosylmethionine binding site [chemical binding]; other site 572477006860 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572477006861 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 572477006862 HDOD domain; Region: HDOD; pfam08668 572477006863 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 572477006864 DNA topoisomerase I; Validated; Region: PRK06599 572477006865 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 572477006866 active site 572477006867 interdomain interaction site; other site 572477006868 putative metal-binding site [ion binding]; other site 572477006869 nucleotide binding site [chemical binding]; other site 572477006870 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 572477006871 domain I; other site 572477006872 DNA binding groove [nucleotide binding] 572477006873 phosphate binding site [ion binding]; other site 572477006874 domain II; other site 572477006875 domain III; other site 572477006876 nucleotide binding site [chemical binding]; other site 572477006877 catalytic site [active] 572477006878 domain IV; other site 572477006879 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 572477006880 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 572477006881 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 572477006882 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 572477006883 Protein of unknown function (DUF494); Region: DUF494; pfam04361 572477006884 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 572477006885 DNA protecting protein DprA; Region: dprA; TIGR00732 572477006886 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572477006887 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 572477006888 active site 572477006889 catalytic residues [active] 572477006890 metal binding site [ion binding]; metal-binding site 572477006891 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 572477006892 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 572477006893 putative active site [active] 572477006894 substrate binding site [chemical binding]; other site 572477006895 putative cosubstrate binding site; other site 572477006896 catalytic site [active] 572477006897 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 572477006898 substrate binding site [chemical binding]; other site 572477006899 16S rRNA methyltransferase B; Provisional; Region: PRK10901 572477006900 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 572477006901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477006902 S-adenosylmethionine binding site [chemical binding]; other site 572477006903 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 572477006904 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 572477006905 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477006906 dimerization interface [polypeptide binding]; other site 572477006907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477006908 dimer interface [polypeptide binding]; other site 572477006909 phosphorylation site [posttranslational modification] 572477006910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477006911 ATP binding site [chemical binding]; other site 572477006912 Mg2+ binding site [ion binding]; other site 572477006913 G-X-G motif; other site 572477006914 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 572477006915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477006916 active site 572477006917 phosphorylation site [posttranslational modification] 572477006918 intermolecular recognition site; other site 572477006919 dimerization interface [polypeptide binding]; other site 572477006920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477006921 Walker A motif; other site 572477006922 ATP binding site [chemical binding]; other site 572477006923 Walker B motif; other site 572477006924 arginine finger; other site 572477006925 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 572477006926 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 572477006927 TrkA-N domain; Region: TrkA_N; pfam02254 572477006928 TrkA-C domain; Region: TrkA_C; pfam02080 572477006929 TrkA-N domain; Region: TrkA_N; pfam02254 572477006930 TrkA-C domain; Region: TrkA_C; pfam02080 572477006931 Cation transport protein; Region: TrkH; cl17365 572477006932 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 572477006933 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 572477006934 Walker A motif; other site 572477006935 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 572477006936 prephenate dehydrogenase; Validated; Region: PRK08507 572477006937 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 572477006938 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572477006939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477006940 homodimer interface [polypeptide binding]; other site 572477006941 catalytic residue [active] 572477006942 Chorismate mutase type II; Region: CM_2; cl00693 572477006943 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 572477006944 Prephenate dehydratase; Region: PDT; pfam00800 572477006945 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 572477006946 putative L-Phe binding site [chemical binding]; other site 572477006947 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 572477006948 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 572477006949 putative ligand binding site [chemical binding]; other site 572477006950 putative NAD binding site [chemical binding]; other site 572477006951 putative catalytic site [active] 572477006952 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 572477006953 L-serine binding site [chemical binding]; other site 572477006954 ACT domain interface; other site 572477006955 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 572477006956 diaminopimelate decarboxylase; Region: lysA; TIGR01048 572477006957 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 572477006958 active site 572477006959 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572477006960 substrate binding site [chemical binding]; other site 572477006961 catalytic residues [active] 572477006962 dimer interface [polypeptide binding]; other site 572477006963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477006964 S-adenosylmethionine binding site [chemical binding]; other site 572477006965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 572477006966 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 572477006967 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 572477006968 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 572477006969 Protein of unknown function, DUF484; Region: DUF484; cl17449 572477006970 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 572477006971 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572477006972 active site 572477006973 DNA binding site [nucleotide binding] 572477006974 Int/Topo IB signature motif; other site 572477006975 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 572477006976 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 572477006977 Cache domain; Region: Cache_1; pfam02743 572477006978 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477006979 dimerization interface [polypeptide binding]; other site 572477006980 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 572477006981 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 572477006982 NMT1/THI5 like; Region: NMT1; pfam09084 572477006983 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 572477006984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 572477006985 ATP binding site [chemical binding]; other site 572477006986 Mg2+ binding site [ion binding]; other site 572477006987 G-X-G motif; other site 572477006988 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 572477006989 anti sigma factor interaction site; other site 572477006990 regulatory phosphorylation site [posttranslational modification]; other site 572477006991 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572477006992 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 572477006993 Zinc-finger domain; Region: zf-CHCC; cl01821 572477006994 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 572477006995 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 572477006996 homodimer interface [polypeptide binding]; other site 572477006997 substrate-cofactor binding pocket; other site 572477006998 catalytic residue [active] 572477006999 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 572477007000 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 572477007001 metal binding triad; other site 572477007002 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 572477007003 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 572477007004 metal binding triad; other site 572477007005 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 572477007006 active site 572477007007 phosphate binding residues; other site 572477007008 catalytic residues [active] 572477007009 pyruvate phosphate dikinase; Provisional; Region: PRK09279 572477007010 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 572477007011 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 572477007012 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 572477007013 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 572477007014 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 572477007015 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572477007016 active site 572477007017 HIGH motif; other site 572477007018 nucleotide binding site [chemical binding]; other site 572477007019 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 572477007020 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 572477007021 active site 572477007022 KMSKS motif; other site 572477007023 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 572477007024 tRNA binding surface [nucleotide binding]; other site 572477007025 anticodon binding site; other site 572477007026 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 572477007027 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 572477007028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477007029 Walker A motif; other site 572477007030 ATP binding site [chemical binding]; other site 572477007031 Walker B motif; other site 572477007032 arginine finger; other site 572477007033 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 572477007034 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 572477007035 VWA-like domain (DUF2201); Region: DUF2201; pfam09967 572477007036 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 572477007037 Peptidase family M48; Region: Peptidase_M48; pfam01435 572477007038 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 572477007039 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 572477007040 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 572477007041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477007042 S-adenosylmethionine binding site [chemical binding]; other site 572477007043 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 572477007044 GTPase RsgA; Reviewed; Region: PRK00098 572477007045 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 572477007046 RNA binding site [nucleotide binding]; other site 572477007047 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 572477007048 GTPase/Zn-binding domain interface [polypeptide binding]; other site 572477007049 GTP/Mg2+ binding site [chemical binding]; other site 572477007050 G4 box; other site 572477007051 G5 box; other site 572477007052 G1 box; other site 572477007053 Switch I region; other site 572477007054 G2 box; other site 572477007055 G3 box; other site 572477007056 Switch II region; other site 572477007057 SET domain; Region: SET; pfam00856 572477007058 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 572477007059 DNA-binding site [nucleotide binding]; DNA binding site 572477007060 RNA-binding motif; other site 572477007061 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 572477007062 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 572477007063 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 572477007064 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 572477007065 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 572477007066 RNA binding site [nucleotide binding]; other site 572477007067 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 572477007068 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 572477007069 Bacitracin resistance protein BacA; Region: BacA; pfam02673 572477007070 homoserine dehydrogenase; Provisional; Region: PRK06349 572477007071 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 572477007072 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 572477007073 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 572477007074 aminotransferase; Validated; Region: PRK08175 572477007075 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572477007076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477007077 homodimer interface [polypeptide binding]; other site 572477007078 catalytic residue [active] 572477007079 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 572477007080 Transglycosylase; Region: Transgly; pfam00912 572477007081 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 572477007082 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 572477007083 dihydropteroate synthase; Region: DHPS; TIGR01496 572477007084 substrate binding pocket [chemical binding]; other site 572477007085 dimer interface [polypeptide binding]; other site 572477007086 inhibitor binding site; inhibition site 572477007087 PilZ domain; Region: PilZ; pfam07238 572477007088 glycogen synthase; Provisional; Region: glgA; PRK00654 572477007089 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 572477007090 ADP-binding pocket [chemical binding]; other site 572477007091 homodimer interface [polypeptide binding]; other site 572477007092 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 572477007093 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 572477007094 active site 572477007095 catalytic site [active] 572477007096 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 572477007097 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 572477007098 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 572477007099 active site 572477007100 catalytic site [active] 572477007101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572477007102 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572477007103 putative substrate translocation pore; other site 572477007104 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 572477007105 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 572477007106 Tetramer interface [polypeptide binding]; other site 572477007107 active site 572477007108 FMN-binding site [chemical binding]; other site 572477007109 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 572477007110 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 572477007111 cyclase homology domain; Region: CHD; cd07302 572477007112 nucleotidyl binding site; other site 572477007113 metal binding site [ion binding]; metal-binding site 572477007114 dimer interface [polypeptide binding]; other site 572477007115 PilZ domain; Region: PilZ; pfam07238 572477007116 Protein of unknown function (DUF454); Region: DUF454; cl01063 572477007117 active site 572477007118 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 572477007119 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 572477007120 putative active site [active] 572477007121 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 572477007122 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572477007123 putative homodimer interface [polypeptide binding]; other site 572477007124 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 572477007125 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 572477007126 active site 572477007127 homodimer interface [polypeptide binding]; other site 572477007128 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 572477007129 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572477007130 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572477007131 Methyltransferase domain; Region: Methyltransf_12; pfam08242 572477007132 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572477007133 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 572477007134 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 572477007135 putative catalytic cysteine [active] 572477007136 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 572477007137 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 572477007138 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 572477007139 active site 572477007140 (T/H)XGH motif; other site 572477007141 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 572477007142 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 572477007143 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 572477007144 folate binding site [chemical binding]; other site 572477007145 NADP+ binding site [chemical binding]; other site 572477007146 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 572477007147 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 572477007148 active site 572477007149 metal binding site [ion binding]; metal-binding site 572477007150 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 572477007151 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 572477007152 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 572477007153 putative hydrolase; Provisional; Region: PRK10985 572477007154 gamma-glutamyl kinase; Provisional; Region: PRK05429 572477007155 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 572477007156 nucleotide binding site [chemical binding]; other site 572477007157 homotetrameric interface [polypeptide binding]; other site 572477007158 putative phosphate binding site [ion binding]; other site 572477007159 putative allosteric binding site; other site 572477007160 PUA domain; Region: PUA; pfam01472 572477007161 GTPase CgtA; Reviewed; Region: obgE; PRK12298 572477007162 GTP1/OBG; Region: GTP1_OBG; pfam01018 572477007163 Obg GTPase; Region: Obg; cd01898 572477007164 G1 box; other site 572477007165 GTP/Mg2+ binding site [chemical binding]; other site 572477007166 Switch I region; other site 572477007167 G2 box; other site 572477007168 G3 box; other site 572477007169 Switch II region; other site 572477007170 G4 box; other site 572477007171 G5 box; other site 572477007172 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 572477007173 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 572477007174 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 572477007175 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 572477007176 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 572477007177 substrate binding pocket [chemical binding]; other site 572477007178 chain length determination region; other site 572477007179 substrate-Mg2+ binding site; other site 572477007180 catalytic residues [active] 572477007181 aspartate-rich region 1; other site 572477007182 active site lid residues [active] 572477007183 aspartate-rich region 2; other site 572477007184 PAS fold; Region: PAS_4; pfam08448 572477007185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477007186 putative active site [active] 572477007187 heme pocket [chemical binding]; other site 572477007188 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572477007189 Zn2+ binding site [ion binding]; other site 572477007190 Mg2+ binding site [ion binding]; other site 572477007191 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 572477007192 dimer interface [polypeptide binding]; other site 572477007193 Citrate synthase; Region: Citrate_synt; pfam00285 572477007194 active site 572477007195 citrylCoA binding site [chemical binding]; other site 572477007196 NADH binding [chemical binding]; other site 572477007197 cationic pore residues; other site 572477007198 oxalacetate/citrate binding site [chemical binding]; other site 572477007199 coenzyme A binding site [chemical binding]; other site 572477007200 catalytic triad [active] 572477007201 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 572477007202 active site 572477007203 catalytic residues [active] 572477007204 metal binding site [ion binding]; metal-binding site 572477007205 Protein of unknown function, DUF485; Region: DUF485; pfam04341 572477007206 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 572477007207 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 572477007208 Na binding site [ion binding]; other site 572477007209 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477007210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477007211 active site 572477007212 phosphorylation site [posttranslational modification] 572477007213 intermolecular recognition site; other site 572477007214 dimerization interface [polypeptide binding]; other site 572477007215 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477007216 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477007217 metal binding site [ion binding]; metal-binding site 572477007218 active site 572477007219 I-site; other site 572477007220 PAS domain S-box; Region: sensory_box; TIGR00229 572477007221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477007222 putative active site [active] 572477007223 heme pocket [chemical binding]; other site 572477007224 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 572477007225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477007226 putative active site [active] 572477007227 heme pocket [chemical binding]; other site 572477007228 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477007229 putative active site [active] 572477007230 heme pocket [chemical binding]; other site 572477007231 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477007232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477007233 dimer interface [polypeptide binding]; other site 572477007234 phosphorylation site [posttranslational modification] 572477007235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477007236 ATP binding site [chemical binding]; other site 572477007237 Mg2+ binding site [ion binding]; other site 572477007238 G-X-G motif; other site 572477007239 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477007240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477007241 active site 572477007242 phosphorylation site [posttranslational modification] 572477007243 intermolecular recognition site; other site 572477007244 dimerization interface [polypeptide binding]; other site 572477007245 Response regulator receiver domain; Region: Response_reg; pfam00072 572477007246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477007247 active site 572477007248 phosphorylation site [posttranslational modification] 572477007249 intermolecular recognition site; other site 572477007250 dimerization interface [polypeptide binding]; other site 572477007251 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 572477007252 putative binding surface; other site 572477007253 active site 572477007254 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 572477007255 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 572477007256 active site 572477007257 metal binding site [ion binding]; metal-binding site 572477007258 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 572477007259 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 572477007260 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572477007261 active site residue [active] 572477007262 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572477007263 active site 572477007264 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 572477007265 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 572477007266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 572477007267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477007268 S-adenosylmethionine binding site [chemical binding]; other site 572477007269 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 572477007270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477007271 Walker A/P-loop; other site 572477007272 ATP binding site [chemical binding]; other site 572477007273 Q-loop/lid; other site 572477007274 ABC transporter signature motif; other site 572477007275 Walker B; other site 572477007276 D-loop; other site 572477007277 H-loop/switch region; other site 572477007278 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 572477007279 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 572477007280 Heme exporter protein D (CcmD); Region: CcmD; cl11475 572477007281 CcmE; Region: CcmE; pfam03100 572477007282 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 572477007283 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 572477007284 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 572477007285 catalytic residues [active] 572477007286 central insert; other site 572477007287 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 572477007288 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 572477007289 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 572477007290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477007291 binding surface 572477007292 TPR motif; other site 572477007293 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 572477007294 substrate binding site [chemical binding]; other site 572477007295 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 572477007296 elongation factor G; Reviewed; Region: PRK12740 572477007297 G1 box; other site 572477007298 putative GEF interaction site [polypeptide binding]; other site 572477007299 GTP/Mg2+ binding site [chemical binding]; other site 572477007300 Switch I region; other site 572477007301 G2 box; other site 572477007302 G3 box; other site 572477007303 Switch II region; other site 572477007304 G4 box; other site 572477007305 G5 box; other site 572477007306 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 572477007307 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 572477007308 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 572477007309 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 572477007310 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 572477007311 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 572477007312 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 572477007313 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 572477007314 Na2 binding site [ion binding]; other site 572477007315 putative substrate binding site 1 [chemical binding]; other site 572477007316 Na binding site 1 [ion binding]; other site 572477007317 putative substrate binding site 2 [chemical binding]; other site 572477007318 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 572477007319 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 572477007320 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 572477007321 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572477007322 RNA binding surface [nucleotide binding]; other site 572477007323 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 572477007324 probable active site [active] 572477007325 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 572477007326 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 572477007327 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 572477007328 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 572477007329 active site 572477007330 HIGH motif; other site 572477007331 dimer interface [polypeptide binding]; other site 572477007332 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572477007333 active site 572477007334 KMSKS motif; other site 572477007335 Peptidase family M50; Region: Peptidase_M50; pfam02163 572477007336 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 572477007337 active site 572477007338 putative substrate binding region [chemical binding]; other site 572477007339 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 572477007340 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 572477007341 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 572477007342 active site 572477007343 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 572477007344 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 572477007345 HDOD domain; Region: HDOD; pfam08668 572477007346 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572477007347 Zn2+ binding site [ion binding]; other site 572477007348 Mg2+ binding site [ion binding]; other site 572477007349 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477007350 metal binding site [ion binding]; metal-binding site 572477007351 active site 572477007352 I-site; other site 572477007353 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477007354 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 572477007355 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 572477007356 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572477007357 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572477007358 hypothetical protein; Provisional; Region: PRK10756 572477007359 CreA protein; Region: CreA; pfam05981 572477007360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 572477007361 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 572477007362 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 572477007363 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572477007364 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572477007365 hypothetical protein; Provisional; Region: PRK05325 572477007366 PrkA family serine protein kinase; Provisional; Region: PRK15455 572477007367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 572477007368 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 572477007369 RRXRR protein; Region: RRXRR; pfam14239 572477007370 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572477007371 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 572477007372 active site 572477007373 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477007374 dimerization interface [polypeptide binding]; other site 572477007375 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572477007376 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477007377 dimer interface [polypeptide binding]; other site 572477007378 putative CheW interface [polypeptide binding]; other site 572477007379 threonine dehydratase; Reviewed; Region: PRK09224 572477007380 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 572477007381 tetramer interface [polypeptide binding]; other site 572477007382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477007383 catalytic residue [active] 572477007384 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 572477007385 putative Ile/Val binding site [chemical binding]; other site 572477007386 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 572477007387 putative Ile/Val binding site [chemical binding]; other site 572477007388 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 572477007389 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 572477007390 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 572477007391 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 572477007392 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572477007393 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 572477007394 putative NAD(P) binding site [chemical binding]; other site 572477007395 active site 572477007396 putative substrate binding site [chemical binding]; other site 572477007397 Putative exonuclease, RdgC; Region: RdgC; pfam04381 572477007398 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 572477007399 Domain of unknown function DUF21; Region: DUF21; pfam01595 572477007400 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 572477007401 Transporter associated domain; Region: CorC_HlyC; smart01091 572477007402 muropeptide transporter; Validated; Region: ampG; cl17669 572477007403 muropeptide transporter; Validated; Region: ampG; cl17669 572477007404 isocitrate dehydrogenase; Validated; Region: PRK07362 572477007405 isocitrate dehydrogenase; Reviewed; Region: PRK07006 572477007406 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 572477007407 DNA-binding site [nucleotide binding]; DNA binding site 572477007408 RNA-binding motif; other site 572477007409 Uncharacterized conserved protein [Function unknown]; Region: COG2127 572477007410 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 572477007411 Clp amino terminal domain; Region: Clp_N; pfam02861 572477007412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477007413 Walker A motif; other site 572477007414 ATP binding site [chemical binding]; other site 572477007415 Walker B motif; other site 572477007416 arginine finger; other site 572477007417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477007418 Walker A motif; other site 572477007419 ATP binding site [chemical binding]; other site 572477007420 Walker B motif; other site 572477007421 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 572477007422 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 572477007423 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477007424 dimerization interface [polypeptide binding]; other site 572477007425 PAS domain; Region: PAS; smart00091 572477007426 PAS domain; Region: PAS_9; pfam13426 572477007427 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477007428 dimer interface [polypeptide binding]; other site 572477007429 putative CheW interface [polypeptide binding]; other site 572477007430 cobyric acid synthase; Provisional; Region: PRK00784 572477007431 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572477007432 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572477007433 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 572477007434 catalytic triad [active] 572477007435 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 572477007436 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 572477007437 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477007438 FeS/SAM binding site; other site 572477007439 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 572477007440 active site 572477007441 SAM binding site [chemical binding]; other site 572477007442 homodimer interface [polypeptide binding]; other site 572477007443 PilZ domain; Region: PilZ; pfam07238 572477007444 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 572477007445 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 572477007446 active site 572477007447 cysteine synthase B; Region: cysM; TIGR01138 572477007448 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 572477007449 dimer interface [polypeptide binding]; other site 572477007450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477007451 catalytic residue [active] 572477007452 Nitrate and nitrite sensing; Region: NIT; pfam08376 572477007453 PAS domain; Region: PAS_9; pfam13426 572477007454 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572477007455 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477007456 dimer interface [polypeptide binding]; other site 572477007457 putative CheW interface [polypeptide binding]; other site 572477007458 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 572477007459 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 572477007460 anti sigma factor interaction site; other site 572477007461 regulatory phosphorylation site [posttranslational modification]; other site 572477007462 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 572477007463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477007464 active site 572477007465 phosphorylation site [posttranslational modification] 572477007466 intermolecular recognition site; other site 572477007467 dimerization interface [polypeptide binding]; other site 572477007468 CheB methylesterase; Region: CheB_methylest; pfam01339 572477007469 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 572477007470 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487 572477007471 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 572477007472 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 572477007473 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 572477007474 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 572477007475 putative CheA interaction surface; other site 572477007476 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477007477 putative binding surface; other site 572477007478 active site 572477007479 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 572477007480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477007481 ATP binding site [chemical binding]; other site 572477007482 Mg2+ binding site [ion binding]; other site 572477007483 G-X-G motif; other site 572477007484 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 572477007485 Response regulator receiver domain; Region: Response_reg; pfam00072 572477007486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477007487 active site 572477007488 phosphorylation site [posttranslational modification] 572477007489 intermolecular recognition site; other site 572477007490 dimerization interface [polypeptide binding]; other site 572477007491 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 572477007492 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 572477007493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572477007494 ATP binding site [chemical binding]; other site 572477007495 putative Mg++ binding site [ion binding]; other site 572477007496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572477007497 nucleotide binding region [chemical binding]; other site 572477007498 ATP-binding site [chemical binding]; other site 572477007499 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 572477007500 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 572477007501 metal binding site 2 [ion binding]; metal-binding site 572477007502 putative DNA binding helix; other site 572477007503 metal binding site 1 [ion binding]; metal-binding site 572477007504 dimer interface [polypeptide binding]; other site 572477007505 structural Zn2+ binding site [ion binding]; other site 572477007506 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 572477007507 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 572477007508 Hemin uptake protein hemP; Region: hemP; pfam10636 572477007509 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 572477007510 Cupin domain; Region: Cupin_2; cl17218 572477007511 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 572477007512 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 572477007513 N-terminal plug; other site 572477007514 ligand-binding site [chemical binding]; other site 572477007515 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 572477007516 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 572477007517 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 572477007518 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 572477007519 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 572477007520 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 572477007521 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 572477007522 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 572477007523 Cna protein B-type domain; Region: Cna_B; pfam05738 572477007524 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 572477007525 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 572477007526 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 572477007527 G1 box; other site 572477007528 GTP/Mg2+ binding site [chemical binding]; other site 572477007529 Switch I region; other site 572477007530 G2 box; other site 572477007531 G3 box; other site 572477007532 Switch II region; other site 572477007533 G4 box; other site 572477007534 G5 box; other site 572477007535 Nucleoside recognition; Region: Gate; pfam07670 572477007536 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 572477007537 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477007538 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477007539 metal binding site [ion binding]; metal-binding site 572477007540 active site 572477007541 I-site; other site 572477007542 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 572477007543 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572477007544 Zn2+ binding site [ion binding]; other site 572477007545 Mg2+ binding site [ion binding]; other site 572477007546 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 572477007547 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572477007548 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 572477007549 putative dimerization interface [polypeptide binding]; other site 572477007550 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 572477007551 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 572477007552 THF binding site; other site 572477007553 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 572477007554 substrate binding site [chemical binding]; other site 572477007555 THF binding site; other site 572477007556 zinc-binding site [ion binding]; other site 572477007557 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 572477007558 metal binding site 2 [ion binding]; metal-binding site 572477007559 putative DNA binding helix; other site 572477007560 metal binding site 1 [ion binding]; metal-binding site 572477007561 dimer interface [polypeptide binding]; other site 572477007562 structural Zn2+ binding site [ion binding]; other site 572477007563 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 572477007564 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572477007565 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 572477007566 FtsX-like permease family; Region: FtsX; pfam02687 572477007567 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572477007568 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 572477007569 Walker A/P-loop; other site 572477007570 ATP binding site [chemical binding]; other site 572477007571 Q-loop/lid; other site 572477007572 ABC transporter signature motif; other site 572477007573 Walker B; other site 572477007574 D-loop; other site 572477007575 H-loop/switch region; other site 572477007576 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 572477007577 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 572477007578 putative metal binding residues [ion binding]; other site 572477007579 hypothetical protein; Validated; Region: PRK01777 572477007580 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 572477007581 putative coenzyme Q binding site [chemical binding]; other site 572477007582 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 572477007583 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 572477007584 active site 572477007585 substrate binding site [chemical binding]; other site 572477007586 metal binding site [ion binding]; metal-binding site 572477007587 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 572477007588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477007589 Walker A motif; other site 572477007590 ATP binding site [chemical binding]; other site 572477007591 Walker B motif; other site 572477007592 arginine finger; other site 572477007593 Peptidase family M41; Region: Peptidase_M41; pfam01434 572477007594 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 572477007595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477007596 S-adenosylmethionine binding site [chemical binding]; other site 572477007597 High potential iron-sulfur protein; Region: HIPIP; pfam01355 572477007598 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 572477007599 NlpC/P60 family; Region: NLPC_P60; pfam00877 572477007600 thioredoxin reductase; Provisional; Region: PRK10262 572477007601 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572477007602 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572477007603 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 572477007604 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 572477007605 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 572477007606 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 572477007607 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477007608 dimer interface [polypeptide binding]; other site 572477007609 putative CheW interface [polypeptide binding]; other site 572477007610 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 572477007611 rRNA binding site [nucleotide binding]; other site 572477007612 predicted 30S ribosome binding site; other site 572477007613 Predicted ATPase [General function prediction only]; Region: COG1485 572477007614 hypothetical protein; Provisional; Region: PRK08960 572477007615 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572477007616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477007617 homodimer interface [polypeptide binding]; other site 572477007618 catalytic residue [active] 572477007619 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 572477007620 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572477007621 motif II; other site 572477007622 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 572477007623 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 572477007624 active site 572477007625 HIGH motif; other site 572477007626 nucleotide binding site [chemical binding]; other site 572477007627 KMSKS motif; other site 572477007628 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477007629 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477007630 metal binding site [ion binding]; metal-binding site 572477007631 active site 572477007632 I-site; other site 572477007633 B12 binding domain; Region: B12-binding_2; pfam02607 572477007634 B12 binding domain; Region: B12-binding; pfam02310 572477007635 B12 binding site [chemical binding]; other site 572477007636 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 572477007637 active site 572477007638 tetramer interface; other site 572477007639 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 572477007640 active site 572477007641 dimer interface [polypeptide binding]; other site 572477007642 tetratricopeptide repeat protein; Provisional; Region: PRK11788 572477007643 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477007644 binding surface 572477007645 TPR motif; other site 572477007646 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 572477007647 classical (c) SDRs; Region: SDR_c; cd05233 572477007648 NAD(P) binding site [chemical binding]; other site 572477007649 active site 572477007650 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 572477007651 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 572477007652 ATP cone domain; Region: ATP-cone; pfam03477 572477007653 Class III ribonucleotide reductase; Region: RNR_III; cd01675 572477007654 effector binding site; other site 572477007655 active site 572477007656 Zn binding site [ion binding]; other site 572477007657 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 572477007658 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 572477007659 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477007660 FeS/SAM binding site; other site 572477007661 MarR family; Region: MarR_2; cl17246 572477007662 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 572477007663 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 572477007664 active site 572477007665 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 572477007666 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 572477007667 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 572477007668 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 572477007669 Uncharacterized conserved protein [Function unknown]; Region: COG1479 572477007670 Protein of unknown function DUF262; Region: DUF262; pfam03235 572477007671 Protein of unknown function DUF262; Region: DUF262; pfam03235 572477007672 Uncharacterized conserved protein [Function unknown]; Region: COG1479 572477007673 Protein of unknown function DUF262; Region: DUF262; pfam03235 572477007674 Protein of unknown function DUF262; Region: DUF262; pfam03235 572477007675 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 572477007676 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 572477007677 putative substrate-binding site; other site 572477007678 nickel binding site [ion binding]; other site 572477007679 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 572477007680 hydrogenase 1 large subunit; Provisional; Region: PRK10170 572477007681 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 572477007682 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 572477007683 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 572477007684 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 572477007685 Predicted permeases [General function prediction only]; Region: COG0679 572477007686 transaldolase-like protein; Provisional; Region: PTZ00411 572477007687 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 572477007688 active site 572477007689 dimer interface [polypeptide binding]; other site 572477007690 catalytic residue [active] 572477007691 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 572477007692 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572477007693 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572477007694 ligand binding site [chemical binding]; other site 572477007695 flexible hinge region; other site 572477007696 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 572477007697 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 572477007698 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 572477007699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477007700 active site 572477007701 phosphorylation site [posttranslational modification] 572477007702 intermolecular recognition site; other site 572477007703 dimerization interface [polypeptide binding]; other site 572477007704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477007705 dimer interface [polypeptide binding]; other site 572477007706 phosphorylation site [posttranslational modification] 572477007707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477007708 ATP binding site [chemical binding]; other site 572477007709 Mg2+ binding site [ion binding]; other site 572477007710 G-X-G motif; other site 572477007711 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477007712 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477007713 putative active site [active] 572477007714 heme pocket [chemical binding]; other site 572477007715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477007716 dimer interface [polypeptide binding]; other site 572477007717 phosphorylation site [posttranslational modification] 572477007718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477007719 ATP binding site [chemical binding]; other site 572477007720 Mg2+ binding site [ion binding]; other site 572477007721 G-X-G motif; other site 572477007722 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 572477007723 CheB methylesterase; Region: CheB_methylest; pfam01339 572477007724 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 572477007725 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 572477007726 PAS domain; Region: PAS_10; pfam13596 572477007727 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477007728 putative active site [active] 572477007729 heme pocket [chemical binding]; other site 572477007730 PAS fold; Region: PAS_4; pfam08448 572477007731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477007732 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477007733 putative active site [active] 572477007734 heme pocket [chemical binding]; other site 572477007735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477007736 dimer interface [polypeptide binding]; other site 572477007737 phosphorylation site [posttranslational modification] 572477007738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477007739 ATP binding site [chemical binding]; other site 572477007740 Mg2+ binding site [ion binding]; other site 572477007741 G-X-G motif; other site 572477007742 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 572477007743 active site 572477007744 iron coordination sites [ion binding]; other site 572477007745 substrate binding pocket [chemical binding]; other site 572477007746 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 572477007747 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572477007748 Walker A motif; other site 572477007749 ATP binding site [chemical binding]; other site 572477007750 Walker B motif; other site 572477007751 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 572477007752 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572477007753 Walker A motif; other site 572477007754 ATP binding site [chemical binding]; other site 572477007755 Walker B motif; other site 572477007756 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 572477007757 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 572477007758 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 572477007759 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 572477007760 Membrane fusogenic activity; Region: BMFP; pfam04380 572477007761 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 572477007762 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 572477007763 Nitrogen regulatory protein P-II; Region: P-II; smart00938 572477007764 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 572477007765 Sensors of blue-light using FAD; Region: BLUF; pfam04940 572477007766 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 572477007767 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 572477007768 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 572477007769 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572477007770 putative active site [active] 572477007771 putative metal binding site [ion binding]; other site 572477007772 argininosuccinate synthase; Provisional; Region: PRK13820 572477007773 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 572477007774 ANP binding site [chemical binding]; other site 572477007775 Substrate Binding Site II [chemical binding]; other site 572477007776 Substrate Binding Site I [chemical binding]; other site 572477007777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 572477007778 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572477007779 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572477007780 substrate binding pocket [chemical binding]; other site 572477007781 membrane-bound complex binding site; other site 572477007782 hinge residues; other site 572477007783 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 572477007784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477007785 putative active site [active] 572477007786 heme pocket [chemical binding]; other site 572477007787 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477007788 putative active site [active] 572477007789 heme pocket [chemical binding]; other site 572477007790 PAS domain; Region: PAS_9; pfam13426 572477007791 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477007792 putative active site [active] 572477007793 heme pocket [chemical binding]; other site 572477007794 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477007795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477007796 dimer interface [polypeptide binding]; other site 572477007797 phosphorylation site [posttranslational modification] 572477007798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477007799 ATP binding site [chemical binding]; other site 572477007800 Mg2+ binding site [ion binding]; other site 572477007801 G-X-G motif; other site 572477007802 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477007803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477007804 active site 572477007805 phosphorylation site [posttranslational modification] 572477007806 intermolecular recognition site; other site 572477007807 dimerization interface [polypeptide binding]; other site 572477007808 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477007809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477007810 active site 572477007811 phosphorylation site [posttranslational modification] 572477007812 intermolecular recognition site; other site 572477007813 dimerization interface [polypeptide binding]; other site 572477007814 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 572477007815 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 572477007816 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 572477007817 ATP binding site [chemical binding]; other site 572477007818 Mg++ binding site [ion binding]; other site 572477007819 motif III; other site 572477007820 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572477007821 nucleotide binding region [chemical binding]; other site 572477007822 ATP-binding site [chemical binding]; other site 572477007823 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 572477007824 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 572477007825 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 572477007826 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 572477007827 alphaNTD homodimer interface [polypeptide binding]; other site 572477007828 alphaNTD - beta interaction site [polypeptide binding]; other site 572477007829 alphaNTD - beta' interaction site [polypeptide binding]; other site 572477007830 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 572477007831 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 572477007832 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 572477007833 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572477007834 RNA binding surface [nucleotide binding]; other site 572477007835 30S ribosomal protein S11; Validated; Region: PRK05309 572477007836 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 572477007837 30S ribosomal protein S13; Region: bact_S13; TIGR03631 572477007838 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 572477007839 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 572477007840 SecY translocase; Region: SecY; pfam00344 572477007841 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 572477007842 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 572477007843 23S rRNA binding site [nucleotide binding]; other site 572477007844 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 572477007845 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 572477007846 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 572477007847 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 572477007848 5S rRNA interface [nucleotide binding]; other site 572477007849 23S rRNA interface [nucleotide binding]; other site 572477007850 L5 interface [polypeptide binding]; other site 572477007851 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 572477007852 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 572477007853 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 572477007854 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 572477007855 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 572477007856 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 572477007857 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 572477007858 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 572477007859 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 572477007860 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 572477007861 RNA binding site [nucleotide binding]; other site 572477007862 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 572477007863 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 572477007864 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 572477007865 23S rRNA interface [nucleotide binding]; other site 572477007866 putative translocon interaction site; other site 572477007867 signal recognition particle (SRP54) interaction site; other site 572477007868 L23 interface [polypeptide binding]; other site 572477007869 trigger factor interaction site; other site 572477007870 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 572477007871 23S rRNA interface [nucleotide binding]; other site 572477007872 5S rRNA interface [nucleotide binding]; other site 572477007873 putative antibiotic binding site [chemical binding]; other site 572477007874 L25 interface [polypeptide binding]; other site 572477007875 L27 interface [polypeptide binding]; other site 572477007876 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 572477007877 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 572477007878 G-X-X-G motif; other site 572477007879 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 572477007880 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 572477007881 putative translocon binding site; other site 572477007882 protein-rRNA interface [nucleotide binding]; other site 572477007883 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 572477007884 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 572477007885 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 572477007886 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 572477007887 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 572477007888 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 572477007889 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 572477007890 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 572477007891 elongation factor Tu; Reviewed; Region: PRK00049 572477007892 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 572477007893 G1 box; other site 572477007894 GEF interaction site [polypeptide binding]; other site 572477007895 GTP/Mg2+ binding site [chemical binding]; other site 572477007896 Switch I region; other site 572477007897 G2 box; other site 572477007898 G3 box; other site 572477007899 Switch II region; other site 572477007900 G4 box; other site 572477007901 G5 box; other site 572477007902 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 572477007903 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 572477007904 Antibiotic Binding Site [chemical binding]; other site 572477007905 elongation factor G; Reviewed; Region: PRK00007 572477007906 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 572477007907 G1 box; other site 572477007908 putative GEF interaction site [polypeptide binding]; other site 572477007909 GTP/Mg2+ binding site [chemical binding]; other site 572477007910 Switch I region; other site 572477007911 G2 box; other site 572477007912 G3 box; other site 572477007913 Switch II region; other site 572477007914 G4 box; other site 572477007915 G5 box; other site 572477007916 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 572477007917 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 572477007918 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 572477007919 30S ribosomal protein S7; Validated; Region: PRK05302 572477007920 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 572477007921 S17 interaction site [polypeptide binding]; other site 572477007922 S8 interaction site; other site 572477007923 16S rRNA interaction site [nucleotide binding]; other site 572477007924 streptomycin interaction site [chemical binding]; other site 572477007925 23S rRNA interaction site [nucleotide binding]; other site 572477007926 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 572477007927 RNA polymerase beta' subunit; Region: rpoC1; CHL00018 572477007928 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 572477007929 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 572477007930 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 572477007931 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 572477007932 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 572477007933 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 572477007934 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 572477007935 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 572477007936 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 572477007937 DNA binding site [nucleotide binding] 572477007938 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 572477007939 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 572477007940 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 572477007941 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 572477007942 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 572477007943 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 572477007944 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 572477007945 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 572477007946 RPB3 interaction site [polypeptide binding]; other site 572477007947 RPB1 interaction site [polypeptide binding]; other site 572477007948 RPB11 interaction site [polypeptide binding]; other site 572477007949 RPB10 interaction site [polypeptide binding]; other site 572477007950 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 572477007951 peripheral dimer interface [polypeptide binding]; other site 572477007952 core dimer interface [polypeptide binding]; other site 572477007953 L10 interface [polypeptide binding]; other site 572477007954 L11 interface [polypeptide binding]; other site 572477007955 putative EF-Tu interaction site [polypeptide binding]; other site 572477007956 putative EF-G interaction site [polypeptide binding]; other site 572477007957 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 572477007958 23S rRNA interface [nucleotide binding]; other site 572477007959 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 572477007960 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 572477007961 mRNA/rRNA interface [nucleotide binding]; other site 572477007962 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 572477007963 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 572477007964 23S rRNA interface [nucleotide binding]; other site 572477007965 L7/L12 interface [polypeptide binding]; other site 572477007966 putative thiostrepton binding site; other site 572477007967 L25 interface [polypeptide binding]; other site 572477007968 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 572477007969 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 572477007970 putative homodimer interface [polypeptide binding]; other site 572477007971 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 572477007972 heterodimer interface [polypeptide binding]; other site 572477007973 homodimer interface [polypeptide binding]; other site 572477007974 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 572477007975 elongation factor Tu; Reviewed; Region: PRK00049 572477007976 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 572477007977 G1 box; other site 572477007978 GEF interaction site [polypeptide binding]; other site 572477007979 GTP/Mg2+ binding site [chemical binding]; other site 572477007980 Switch I region; other site 572477007981 G2 box; other site 572477007982 G3 box; other site 572477007983 Switch II region; other site 572477007984 G4 box; other site 572477007985 G5 box; other site 572477007986 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 572477007987 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 572477007988 Antibiotic Binding Site [chemical binding]; other site 572477007989 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 572477007990 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 572477007991 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 572477007992 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 572477007993 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 572477007994 putative active site [active] 572477007995 catalytic residue [active] 572477007996 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 572477007997 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 572477007998 5S rRNA interface [nucleotide binding]; other site 572477007999 CTC domain interface [polypeptide binding]; other site 572477008000 L16 interface [polypeptide binding]; other site 572477008001 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 572477008002 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 572477008003 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572477008004 active site 572477008005 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 572477008006 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 572477008007 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 572477008008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477008009 TPR motif; other site 572477008010 binding surface 572477008011 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477008012 TPR motif; other site 572477008013 binding surface 572477008014 TPR repeat; Region: TPR_11; pfam13414 572477008015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477008016 binding surface 572477008017 TPR repeat; Region: TPR_11; pfam13414 572477008018 TPR motif; other site 572477008019 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 572477008020 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 572477008021 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 572477008022 tRNA; other site 572477008023 putative tRNA binding site [nucleotide binding]; other site 572477008024 putative NADP binding site [chemical binding]; other site 572477008025 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 572477008026 peptide chain release factor 1; Validated; Region: prfA; PRK00591 572477008027 This domain is found in peptide chain release factors; Region: PCRF; smart00937 572477008028 RF-1 domain; Region: RF-1; pfam00472 572477008029 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 572477008030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477008031 S-adenosylmethionine binding site [chemical binding]; other site 572477008032 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 572477008033 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 572477008034 putative acyl-acceptor binding pocket; other site 572477008035 CAAX protease self-immunity; Region: Abi; pfam02517 572477008036 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 572477008037 DctM-like transporters; Region: DctM; pfam06808 572477008038 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 572477008039 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477008040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008041 active site 572477008042 phosphorylation site [posttranslational modification] 572477008043 intermolecular recognition site; other site 572477008044 dimerization interface [polypeptide binding]; other site 572477008045 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477008046 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477008047 metal binding site [ion binding]; metal-binding site 572477008048 active site 572477008049 I-site; other site 572477008050 PAS domain S-box; Region: sensory_box; TIGR00229 572477008051 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477008052 putative active site [active] 572477008053 heme pocket [chemical binding]; other site 572477008054 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477008055 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477008056 putative active site [active] 572477008057 heme pocket [chemical binding]; other site 572477008058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477008059 dimer interface [polypeptide binding]; other site 572477008060 phosphorylation site [posttranslational modification] 572477008061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477008062 ATP binding site [chemical binding]; other site 572477008063 Mg2+ binding site [ion binding]; other site 572477008064 G-X-G motif; other site 572477008065 Response regulator receiver domain; Region: Response_reg; pfam00072 572477008066 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477008067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008068 active site 572477008069 phosphorylation site [posttranslational modification] 572477008070 intermolecular recognition site; other site 572477008071 dimerization interface [polypeptide binding]; other site 572477008072 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 572477008073 signal recognition particle protein; Provisional; Region: PRK10867 572477008074 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 572477008075 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 572477008076 P loop; other site 572477008077 GTP binding site [chemical binding]; other site 572477008078 Signal peptide binding domain; Region: SRP_SPB; pfam02978 572477008079 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 572477008080 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 572477008081 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 572477008082 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 572477008083 ssDNA binding site [nucleotide binding]; other site 572477008084 dimer interface [polypeptide binding]; other site 572477008085 tetramer (dimer of dimers) interface [polypeptide binding]; other site 572477008086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 572477008087 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 572477008088 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 572477008089 active site 572477008090 metal binding site [ion binding]; metal-binding site 572477008091 interdomain interaction site; other site 572477008092 Domain of unknown function (DUF927); Region: DUF927; pfam06048 572477008093 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 572477008094 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 572477008095 active site 572477008096 Int/Topo IB signature motif; other site 572477008097 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 572477008098 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 572477008099 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 572477008100 dihydrodipicolinate synthase; Region: dapA; TIGR00674 572477008101 dimer interface [polypeptide binding]; other site 572477008102 active site 572477008103 catalytic residue [active] 572477008104 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 572477008105 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572477008106 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 572477008107 putative active site [active] 572477008108 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 572477008109 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572477008110 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 572477008111 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 572477008112 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572477008113 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 572477008114 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 572477008115 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 572477008116 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 572477008117 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572477008118 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 572477008119 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 572477008120 NADH dehydrogenase subunit G; Validated; Region: PRK09129 572477008121 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572477008122 catalytic loop [active] 572477008123 iron binding site [ion binding]; other site 572477008124 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 572477008125 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 572477008126 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 572477008127 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 572477008128 SLBB domain; Region: SLBB; pfam10531 572477008129 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 572477008130 NADH dehydrogenase subunit E; Validated; Region: PRK07539 572477008131 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 572477008132 putative dimer interface [polypeptide binding]; other site 572477008133 [2Fe-2S] cluster binding site [ion binding]; other site 572477008134 NADH dehydrogenase subunit D; Validated; Region: PRK06075 572477008135 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 572477008136 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 572477008137 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 572477008138 NADH dehydrogenase subunit B; Validated; Region: PRK06411 572477008139 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 572477008140 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 572477008141 triosephosphate isomerase; Provisional; Region: PRK14567 572477008142 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 572477008143 substrate binding site [chemical binding]; other site 572477008144 dimer interface [polypeptide binding]; other site 572477008145 catalytic triad [active] 572477008146 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 572477008147 SmpB-tmRNA interface; other site 572477008148 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 572477008149 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 572477008150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 572477008151 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 572477008152 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 572477008153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 572477008154 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 572477008155 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 572477008156 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 572477008157 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 572477008158 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572477008159 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 572477008160 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572477008161 motif II; other site 572477008162 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 572477008163 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 572477008164 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 572477008165 putative ATP binding site [chemical binding]; other site 572477008166 putative substrate interface [chemical binding]; other site 572477008167 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 572477008168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572477008169 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 572477008170 substrate binding site [chemical binding]; other site 572477008171 dimerization interface [polypeptide binding]; other site 572477008172 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 572477008173 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 572477008174 Walker A/P-loop; other site 572477008175 ATP binding site [chemical binding]; other site 572477008176 Q-loop/lid; other site 572477008177 ABC transporter signature motif; other site 572477008178 Walker B; other site 572477008179 D-loop; other site 572477008180 H-loop/switch region; other site 572477008181 TOBE-like domain; Region: TOBE_3; pfam12857 572477008182 sulfate transport protein; Provisional; Region: cysT; CHL00187 572477008183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572477008184 dimer interface [polypeptide binding]; other site 572477008185 conserved gate region; other site 572477008186 putative PBP binding loops; other site 572477008187 ABC-ATPase subunit interface; other site 572477008188 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 572477008189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572477008190 dimer interface [polypeptide binding]; other site 572477008191 conserved gate region; other site 572477008192 putative PBP binding loops; other site 572477008193 ABC-ATPase subunit interface; other site 572477008194 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 572477008195 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 572477008196 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 572477008197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572477008198 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 572477008199 substrate binding site [chemical binding]; other site 572477008200 dimerization interface [polypeptide binding]; other site 572477008201 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 572477008202 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 572477008203 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 572477008204 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 572477008205 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 572477008206 Active Sites [active] 572477008207 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 572477008208 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 572477008209 Active Sites [active] 572477008210 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 572477008211 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 572477008212 CysD dimerization site [polypeptide binding]; other site 572477008213 G1 box; other site 572477008214 putative GEF interaction site [polypeptide binding]; other site 572477008215 GTP/Mg2+ binding site [chemical binding]; other site 572477008216 Switch I region; other site 572477008217 G2 box; other site 572477008218 G3 box; other site 572477008219 Switch II region; other site 572477008220 G4 box; other site 572477008221 G5 box; other site 572477008222 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 572477008223 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 572477008224 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 572477008225 dimerization interface [polypeptide binding]; other site 572477008226 putative ATP binding site [chemical binding]; other site 572477008227 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 572477008228 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 572477008229 molybdopterin cofactor binding site; other site 572477008230 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 572477008231 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 572477008232 molybdopterin cofactor binding site; other site 572477008233 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 572477008234 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 572477008235 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 572477008236 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 572477008237 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 572477008238 HAMP domain; Region: HAMP; pfam00672 572477008239 dimerization interface [polypeptide binding]; other site 572477008240 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572477008241 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477008242 dimer interface [polypeptide binding]; other site 572477008243 putative CheW interface [polypeptide binding]; other site 572477008244 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 572477008245 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 572477008246 DHH family; Region: DHH; pfam01368 572477008247 FOG: CBS domain [General function prediction only]; Region: COG0517 572477008248 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 572477008249 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 572477008250 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 572477008251 Cytochrome c; Region: Cytochrom_C; pfam00034 572477008252 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 572477008253 homodimer interaction site [polypeptide binding]; other site 572477008254 cofactor binding site; other site 572477008255 Response regulator receiver domain; Region: Response_reg; pfam00072 572477008256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008257 active site 572477008258 phosphorylation site [posttranslational modification] 572477008259 intermolecular recognition site; other site 572477008260 dimerization interface [polypeptide binding]; other site 572477008261 Chemotaxis phosphatase CheX; Region: CheX; cl15816 572477008262 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 572477008263 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477008264 putative active site [active] 572477008265 heme pocket [chemical binding]; other site 572477008266 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477008267 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477008268 metal binding site [ion binding]; metal-binding site 572477008269 active site 572477008270 I-site; other site 572477008271 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477008272 dimer interface [polypeptide binding]; other site 572477008273 putative CheW interface [polypeptide binding]; other site 572477008274 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477008275 dimer interface [polypeptide binding]; other site 572477008276 putative CheW interface [polypeptide binding]; other site 572477008277 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 572477008278 CheW-like domain; Region: CheW; pfam01584 572477008279 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 572477008280 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 572477008281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008282 active site 572477008283 phosphorylation site [posttranslational modification] 572477008284 intermolecular recognition site; other site 572477008285 dimerization interface [polypeptide binding]; other site 572477008286 CheB methylesterase; Region: CheB_methylest; pfam01339 572477008287 HEAT repeats; Region: HEAT_2; pfam13646 572477008288 HEAT repeats; Region: HEAT_2; pfam13646 572477008289 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 572477008290 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 572477008291 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 572477008292 Response regulator receiver domain; Region: Response_reg; pfam00072 572477008293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008294 active site 572477008295 phosphorylation site [posttranslational modification] 572477008296 intermolecular recognition site; other site 572477008297 dimerization interface [polypeptide binding]; other site 572477008298 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477008299 putative binding surface; other site 572477008300 active site 572477008301 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 572477008302 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 572477008303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477008304 ATP binding site [chemical binding]; other site 572477008305 Mg2+ binding site [ion binding]; other site 572477008306 G-X-G motif; other site 572477008307 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 572477008308 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477008309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008310 active site 572477008311 phosphorylation site [posttranslational modification] 572477008312 intermolecular recognition site; other site 572477008313 dimerization interface [polypeptide binding]; other site 572477008314 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 572477008315 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 572477008316 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 572477008317 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 572477008318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477008319 ATP binding site [chemical binding]; other site 572477008320 Mg2+ binding site [ion binding]; other site 572477008321 G-X-G motif; other site 572477008322 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 572477008323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 572477008324 ATP binding site [chemical binding]; other site 572477008325 G-X-G motif; other site 572477008326 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 572477008327 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477008328 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 572477008329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477008330 dimer interface [polypeptide binding]; other site 572477008331 phosphorylation site [posttranslational modification] 572477008332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477008333 ATP binding site [chemical binding]; other site 572477008334 Mg2+ binding site [ion binding]; other site 572477008335 G-X-G motif; other site 572477008336 Response regulator receiver domain; Region: Response_reg; pfam00072 572477008337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008338 active site 572477008339 phosphorylation site [posttranslational modification] 572477008340 intermolecular recognition site; other site 572477008341 dimerization interface [polypeptide binding]; other site 572477008342 exonuclease I; Provisional; Region: sbcB; PRK11779 572477008343 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 572477008344 active site 572477008345 catalytic site [active] 572477008346 substrate binding site [chemical binding]; other site 572477008347 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 572477008348 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 572477008349 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 572477008350 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 572477008351 RimM N-terminal domain; Region: RimM; pfam01782 572477008352 PRC-barrel domain; Region: PRC; pfam05239 572477008353 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 572477008354 Protein of unknown function, DUF399; Region: DUF399; pfam04187 572477008355 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 572477008356 protein binding site [polypeptide binding]; other site 572477008357 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 572477008358 Zn binding site [ion binding]; other site 572477008359 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477008360 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477008361 putative active site [active] 572477008362 heme pocket [chemical binding]; other site 572477008363 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477008364 dimer interface [polypeptide binding]; other site 572477008365 phosphorylation site [posttranslational modification] 572477008366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477008367 ATP binding site [chemical binding]; other site 572477008368 Mg2+ binding site [ion binding]; other site 572477008369 G-X-G motif; other site 572477008370 Response regulator receiver domain; Region: Response_reg; pfam00072 572477008371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008372 active site 572477008373 phosphorylation site [posttranslational modification] 572477008374 intermolecular recognition site; other site 572477008375 dimerization interface [polypeptide binding]; other site 572477008376 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 572477008377 putative binding surface; other site 572477008378 active site 572477008379 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 572477008380 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 572477008381 4Fe-4S binding domain; Region: Fer4; pfam00037 572477008382 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 572477008383 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 572477008384 molybdopterin cofactor binding site; other site 572477008385 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 572477008386 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 572477008387 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 572477008388 putative molybdopterin cofactor binding site; other site 572477008389 homoserine O-succinyltransferase; Provisional; Region: PRK05368 572477008390 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 572477008391 conserved cys residue [active] 572477008392 ABC transporter ATPase component; Reviewed; Region: PRK11147 572477008393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477008394 Walker A/P-loop; other site 572477008395 ATP binding site [chemical binding]; other site 572477008396 ABC transporter signature motif; other site 572477008397 Walker B; other site 572477008398 D-loop; other site 572477008399 H-loop/switch region; other site 572477008400 ABC transporter; Region: ABC_tran_2; pfam12848 572477008401 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572477008402 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572477008403 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572477008404 ligand binding site [chemical binding]; other site 572477008405 flexible hinge region; other site 572477008406 non-specific DNA interactions [nucleotide binding]; other site 572477008407 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 572477008408 DNA binding site [nucleotide binding] 572477008409 sequence specific DNA binding site [nucleotide binding]; other site 572477008410 putative cAMP binding site [chemical binding]; other site 572477008411 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 572477008412 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 572477008413 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 572477008414 cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203 572477008415 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 572477008416 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 572477008417 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 572477008418 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 572477008419 ligand binding site [chemical binding]; other site 572477008420 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 572477008421 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 572477008422 N-acetyl-D-glucosamine binding site [chemical binding]; other site 572477008423 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 572477008424 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 572477008425 minor groove reading motif; other site 572477008426 helix-hairpin-helix signature motif; other site 572477008427 substrate binding pocket [chemical binding]; other site 572477008428 active site 572477008429 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 572477008430 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 572477008431 Protein required for attachment to host cells; Region: Host_attach; pfam10116 572477008432 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 572477008433 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572477008434 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572477008435 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572477008436 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 572477008437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008438 active site 572477008439 phosphorylation site [posttranslational modification] 572477008440 intermolecular recognition site; other site 572477008441 dimerization interface [polypeptide binding]; other site 572477008442 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572477008443 Zn2+ binding site [ion binding]; other site 572477008444 Mg2+ binding site [ion binding]; other site 572477008445 Helix-turn-helix domain; Region: HTH_17; pfam12728 572477008446 Response regulator receiver domain; Region: Response_reg; pfam00072 572477008447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008448 active site 572477008449 phosphorylation site [posttranslational modification] 572477008450 intermolecular recognition site; other site 572477008451 dimerization interface [polypeptide binding]; other site 572477008452 Response regulator receiver domain; Region: Response_reg; pfam00072 572477008453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008454 active site 572477008455 phosphorylation site [posttranslational modification] 572477008456 intermolecular recognition site; other site 572477008457 dimerization interface [polypeptide binding]; other site 572477008458 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 572477008459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477008460 putative active site [active] 572477008461 heme pocket [chemical binding]; other site 572477008462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477008463 dimer interface [polypeptide binding]; other site 572477008464 phosphorylation site [posttranslational modification] 572477008465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477008466 ATP binding site [chemical binding]; other site 572477008467 Mg2+ binding site [ion binding]; other site 572477008468 G-X-G motif; other site 572477008469 Response regulator receiver domain; Region: Response_reg; pfam00072 572477008470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008471 active site 572477008472 phosphorylation site [posttranslational modification] 572477008473 intermolecular recognition site; other site 572477008474 dimerization interface [polypeptide binding]; other site 572477008475 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477008476 putative binding surface; other site 572477008477 active site 572477008478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008479 Response regulator receiver domain; Region: Response_reg; pfam00072 572477008480 active site 572477008481 phosphorylation site [posttranslational modification] 572477008482 intermolecular recognition site; other site 572477008483 dimerization interface [polypeptide binding]; other site 572477008484 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 572477008485 HlyD family secretion protein; Region: HlyD_3; pfam13437 572477008486 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 572477008487 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 572477008488 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 572477008489 phosphoserine phosphatase SerB; Region: serB; TIGR00338 572477008490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572477008491 motif II; other site 572477008492 peptidase PmbA; Provisional; Region: PRK11040 572477008493 protease TldD; Provisional; Region: tldD; PRK10735 572477008494 nitrilase; Region: PLN02798 572477008495 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 572477008496 putative active site [active] 572477008497 catalytic triad [active] 572477008498 dimer interface [polypeptide binding]; other site 572477008499 TIGR02099 family protein; Region: TIGR02099 572477008500 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 572477008501 ribonuclease G; Provisional; Region: PRK11712 572477008502 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 572477008503 homodimer interface [polypeptide binding]; other site 572477008504 oligonucleotide binding site [chemical binding]; other site 572477008505 Maf-like protein; Region: Maf; pfam02545 572477008506 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 572477008507 active site 572477008508 dimer interface [polypeptide binding]; other site 572477008509 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 572477008510 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 572477008511 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 572477008512 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 572477008513 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 572477008514 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 572477008515 HlyD family secretion protein; Region: HlyD_3; pfam13437 572477008516 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 572477008517 Protein export membrane protein; Region: SecD_SecF; cl14618 572477008518 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 572477008519 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 572477008520 ssDNA binding site; other site 572477008521 generic binding surface II; other site 572477008522 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572477008523 ATP binding site [chemical binding]; other site 572477008524 putative Mg++ binding site [ion binding]; other site 572477008525 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572477008526 nucleotide binding region [chemical binding]; other site 572477008527 ATP-binding site [chemical binding]; other site 572477008528 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 572477008529 putative active site [active] 572477008530 Transglycosylase SLT domain; Region: SLT_2; pfam13406 572477008531 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 572477008532 N-acetyl-D-glucosamine binding site [chemical binding]; other site 572477008533 catalytic residue [active] 572477008534 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 572477008535 homotrimer interaction site [polypeptide binding]; other site 572477008536 putative active site [active] 572477008537 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 572477008538 ATP binding site [chemical binding]; other site 572477008539 active site 572477008540 substrate binding site [chemical binding]; other site 572477008541 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 572477008542 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 572477008543 Sulfate transporter family; Region: Sulfate_transp; pfam00916 572477008544 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 572477008545 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 572477008546 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 572477008547 Substrate binding site; other site 572477008548 metal-binding site 572477008549 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 572477008550 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 572477008551 active site 572477008552 Zn binding site [ion binding]; other site 572477008553 lipoyl synthase; Provisional; Region: PRK05481 572477008554 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477008555 FeS/SAM binding site; other site 572477008556 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 572477008557 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 572477008558 active site 572477008559 metal binding site [ion binding]; metal-binding site 572477008560 nudix motif; other site 572477008561 Ribulose bisphosphate carboxylase like proteins from phototrophic bacteria; Region: RLP_Photo; cd08208 572477008562 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 572477008563 dimer interface [polypeptide binding]; other site 572477008564 active site 572477008565 catalytic residue [active] 572477008566 metal binding site [ion binding]; metal-binding site 572477008567 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 572477008568 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 572477008569 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 572477008570 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cd09224 572477008571 subunit interface [polypeptide binding]; other site 572477008572 Heme binding sites [chemical binding]; other site 572477008573 Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291 572477008574 subunit H interface; other site 572477008575 subunit L interface; other site 572477008576 bacteriopheophytin binding site; other site 572477008577 carotenoid binding site; other site 572477008578 bacteriochlorophyll binding site; other site 572477008579 cytochrome C interface; other site 572477008580 quinone binding site; other site 572477008581 Fe binding site [ion binding]; other site 572477008582 Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290 572477008583 subunit M interface; other site 572477008584 subunit H interface; other site 572477008585 quinone binding site; other site 572477008586 bacteriopheophytin binding site; other site 572477008587 bacteriochlorophyll binding site; other site 572477008588 cytochrome C subunit interface; other site 572477008589 Fe binding site [ion binding]; other site 572477008590 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 572477008591 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 572477008592 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 572477008593 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 572477008594 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 572477008595 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 572477008596 Predicted acetyltransferase [General function prediction only]; Region: COG5628 572477008597 Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY). Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980 572477008598 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 572477008599 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572477008600 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 572477008601 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 572477008602 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 572477008603 O-methyltransferase; Region: Methyltransf_2; pfam00891 572477008604 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 572477008605 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 572477008606 substrate binding pocket [chemical binding]; other site 572477008607 chain length determination region; other site 572477008608 substrate-Mg2+ binding site; other site 572477008609 catalytic residues [active] 572477008610 aspartate-rich region 1; other site 572477008611 active site lid residues [active] 572477008612 aspartate-rich region 2; other site 572477008613 phytoene desaturase; Region: crtI_fam; TIGR02734 572477008614 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572477008615 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 572477008616 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 572477008617 active site lid residues [active] 572477008618 substrate binding pocket [chemical binding]; other site 572477008619 catalytic residues [active] 572477008620 substrate-Mg2+ binding site; other site 572477008621 aspartate-rich region 1; other site 572477008622 aspartate-rich region 2; other site 572477008623 phytoene desaturase; Region: crtI_fam; TIGR02734 572477008624 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572477008625 putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056 572477008626 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 572477008627 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572477008628 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572477008629 DNA binding residues [nucleotide binding] 572477008630 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 572477008631 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 572477008632 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 572477008633 catalytic residues [active] 572477008634 hinge region; other site 572477008635 alpha helical domain; other site 572477008636 PUCC protein; Region: PUCC; pfam03209 572477008637 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 572477008638 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477008639 dimerization interface [polypeptide binding]; other site 572477008640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477008641 dimer interface [polypeptide binding]; other site 572477008642 phosphorylation site [posttranslational modification] 572477008643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477008644 ATP binding site [chemical binding]; other site 572477008645 Mg2+ binding site [ion binding]; other site 572477008646 G-X-G motif; other site 572477008647 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 572477008648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008649 active site 572477008650 phosphorylation site [posttranslational modification] 572477008651 intermolecular recognition site; other site 572477008652 dimerization interface [polypeptide binding]; other site 572477008653 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572477008654 DNA binding site [nucleotide binding] 572477008655 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 572477008656 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 572477008657 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 572477008658 tellurite resistance protein terB; Region: terB; cd07176 572477008659 putative metal binding site [ion binding]; other site 572477008660 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 572477008661 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 572477008662 putative metal binding site [ion binding]; other site 572477008663 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 572477008664 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 572477008665 putative metal binding site [ion binding]; other site 572477008666 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 572477008667 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 572477008668 putative metal binding site [ion binding]; other site 572477008669 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572477008670 active site 572477008671 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 572477008672 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 572477008673 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 572477008674 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 572477008675 putative metal binding site [ion binding]; other site 572477008676 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 572477008677 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 572477008678 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 572477008679 putative metal binding site [ion binding]; other site 572477008680 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 572477008681 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 572477008682 Transposase IS200 like; Region: Y1_Tnp; pfam01797 572477008683 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 572477008684 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 572477008685 Probable transposase; Region: OrfB_IS605; pfam01385 572477008686 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 572477008687 siroheme synthase; Provisional; Region: cysG; PRK10637 572477008688 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 572477008689 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 572477008690 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 572477008691 active site 572477008692 SAM binding site [chemical binding]; other site 572477008693 homodimer interface [polypeptide binding]; other site 572477008694 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572477008695 active site residue [active] 572477008696 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 572477008697 CPxP motif; other site 572477008698 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 572477008699 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 572477008700 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 572477008701 PYR/PP interface [polypeptide binding]; other site 572477008702 dimer interface [polypeptide binding]; other site 572477008703 TPP binding site [chemical binding]; other site 572477008704 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 572477008705 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 572477008706 TPP-binding site [chemical binding]; other site 572477008707 dimer interface [polypeptide binding]; other site 572477008708 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477008709 dimerization interface [polypeptide binding]; other site 572477008710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477008711 dimer interface [polypeptide binding]; other site 572477008712 phosphorylation site [posttranslational modification] 572477008713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477008714 ATP binding site [chemical binding]; other site 572477008715 Mg2+ binding site [ion binding]; other site 572477008716 G-X-G motif; other site 572477008717 Response regulator receiver domain; Region: Response_reg; pfam00072 572477008718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008719 active site 572477008720 phosphorylation site [posttranslational modification] 572477008721 intermolecular recognition site; other site 572477008722 dimerization interface [polypeptide binding]; other site 572477008723 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477008724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008725 active site 572477008726 phosphorylation site [posttranslational modification] 572477008727 intermolecular recognition site; other site 572477008728 dimerization interface [polypeptide binding]; other site 572477008729 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 572477008730 GAF domain; Region: GAF_2; pfam13185 572477008731 PAS domain S-box; Region: sensory_box; TIGR00229 572477008732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477008733 PAS fold; Region: PAS_3; pfam08447 572477008734 putative active site [active] 572477008735 heme pocket [chemical binding]; other site 572477008736 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477008737 PAS domain; Region: PAS_9; pfam13426 572477008738 putative active site [active] 572477008739 heme pocket [chemical binding]; other site 572477008740 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477008741 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477008742 putative active site [active] 572477008743 heme pocket [chemical binding]; other site 572477008744 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477008745 dimer interface [polypeptide binding]; other site 572477008746 phosphorylation site [posttranslational modification] 572477008747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477008748 ATP binding site [chemical binding]; other site 572477008749 Mg2+ binding site [ion binding]; other site 572477008750 G-X-G motif; other site 572477008751 Response regulator receiver domain; Region: Response_reg; pfam00072 572477008752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008753 active site 572477008754 phosphorylation site [posttranslational modification] 572477008755 intermolecular recognition site; other site 572477008756 dimerization interface [polypeptide binding]; other site 572477008757 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 572477008758 malate synthase G; Provisional; Region: PRK02999 572477008759 active site 572477008760 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 572477008761 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 572477008762 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 572477008763 putative active site [active] 572477008764 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572477008765 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 572477008766 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 572477008767 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 572477008768 putative ADP-binding pocket [chemical binding]; other site 572477008769 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572477008770 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 572477008771 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 572477008772 CHASE4 domain; Region: CHASE4; pfam05228 572477008773 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477008774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477008775 dimer interface [polypeptide binding]; other site 572477008776 phosphorylation site [posttranslational modification] 572477008777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477008778 ATP binding site [chemical binding]; other site 572477008779 Mg2+ binding site [ion binding]; other site 572477008780 G-X-G motif; other site 572477008781 Response regulator receiver domain; Region: Response_reg; pfam00072 572477008782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008783 active site 572477008784 phosphorylation site [posttranslational modification] 572477008785 intermolecular recognition site; other site 572477008786 dimerization interface [polypeptide binding]; other site 572477008787 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477008788 putative binding surface; other site 572477008789 active site 572477008790 Response regulator receiver domain; Region: Response_reg; pfam00072 572477008791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008792 active site 572477008793 phosphorylation site [posttranslational modification] 572477008794 intermolecular recognition site; other site 572477008795 dimerization interface [polypeptide binding]; other site 572477008796 HDOD domain; Region: HDOD; pfam08668 572477008797 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 572477008798 ATP-grasp domain; Region: ATP-grasp; pfam02222 572477008799 AIR carboxylase; Region: AIRC; pfam00731 572477008800 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 572477008801 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 572477008802 Walker A motif; other site 572477008803 ATP binding site [chemical binding]; other site 572477008804 Walker B motif; other site 572477008805 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 572477008806 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572477008807 Walker A motif; other site 572477008808 ATP binding site [chemical binding]; other site 572477008809 Walker B motif; other site 572477008810 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 572477008811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008812 active site 572477008813 phosphorylation site [posttranslational modification] 572477008814 intermolecular recognition site; other site 572477008815 dimerization interface [polypeptide binding]; other site 572477008816 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572477008817 Zn2+ binding site [ion binding]; other site 572477008818 Mg2+ binding site [ion binding]; other site 572477008819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008820 Response regulator receiver domain; Region: Response_reg; pfam00072 572477008821 active site 572477008822 phosphorylation site [posttranslational modification] 572477008823 intermolecular recognition site; other site 572477008824 dimerization interface [polypeptide binding]; other site 572477008825 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 572477008826 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477008827 PAS domain; Region: PAS_9; pfam13426 572477008828 putative active site [active] 572477008829 heme pocket [chemical binding]; other site 572477008830 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477008831 PAS fold; Region: PAS_3; pfam08447 572477008832 putative active site [active] 572477008833 heme pocket [chemical binding]; other site 572477008834 GAF domain; Region: GAF_2; pfam13185 572477008835 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 572477008836 PAS domain; Region: PAS_9; pfam13426 572477008837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477008838 putative active site [active] 572477008839 heme pocket [chemical binding]; other site 572477008840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477008841 dimer interface [polypeptide binding]; other site 572477008842 phosphorylation site [posttranslational modification] 572477008843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477008844 ATP binding site [chemical binding]; other site 572477008845 Mg2+ binding site [ion binding]; other site 572477008846 G-X-G motif; other site 572477008847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008848 active site 572477008849 phosphorylation site [posttranslational modification] 572477008850 intermolecular recognition site; other site 572477008851 dimerization interface [polypeptide binding]; other site 572477008852 Response regulator receiver domain; Region: Response_reg; pfam00072 572477008853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477008854 active site 572477008855 phosphorylation site [posttranslational modification] 572477008856 intermolecular recognition site; other site 572477008857 dimerization interface [polypeptide binding]; other site 572477008858 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 572477008859 putative binding surface; other site 572477008860 active site 572477008861 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477008862 PAS domain; Region: PAS_9; pfam13426 572477008863 putative active site [active] 572477008864 heme pocket [chemical binding]; other site 572477008865 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477008866 PAS domain; Region: PAS_9; pfam13426 572477008867 putative active site [active] 572477008868 heme pocket [chemical binding]; other site 572477008869 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477008870 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477008871 metal binding site [ion binding]; metal-binding site 572477008872 active site 572477008873 I-site; other site 572477008874 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477008875 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 572477008876 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 572477008877 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 572477008878 dimer interface [polypeptide binding]; other site 572477008879 PYR/PP interface [polypeptide binding]; other site 572477008880 TPP binding site [chemical binding]; other site 572477008881 substrate binding site [chemical binding]; other site 572477008882 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 572477008883 TPP-binding site; other site 572477008884 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 572477008885 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572477008886 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 572477008887 acyl-activating enzyme (AAE) consensus motif; other site 572477008888 AMP binding site [chemical binding]; other site 572477008889 active site 572477008890 CoA binding site [chemical binding]; other site 572477008891 ACT domain-containing protein [General function prediction only]; Region: COG4747 572477008892 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 572477008893 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 572477008894 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 572477008895 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572477008896 acyl-activating enzyme (AAE) consensus motif; other site 572477008897 AMP binding site [chemical binding]; other site 572477008898 active site 572477008899 CoA binding site [chemical binding]; other site 572477008900 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 572477008901 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 572477008902 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 572477008903 putative metal binding site [ion binding]; other site 572477008904 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 572477008905 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572477008906 acyl-activating enzyme (AAE) consensus motif; other site 572477008907 AMP binding site [chemical binding]; other site 572477008908 active site 572477008909 CoA binding site [chemical binding]; other site 572477008910 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 572477008911 V4R domain; Region: V4R; cl15268 572477008912 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 572477008913 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477008914 FeS/SAM binding site; other site 572477008915 HemN C-terminal domain; Region: HemN_C; pfam06969 572477008916 Protein of unknown function (DUF3623); Region: DUF3623; pfam12291 572477008917 putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054 572477008918 Bacterial PH domain; Region: DUF304; pfam03703 572477008919 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581 572477008920 photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150 572477008921 subunit M interaction residues [polypeptide binding]; other site 572477008922 subunit L interaction residues [polypeptide binding]; other site 572477008923 putative proton transfer pathway, P1; other site 572477008924 putative proton transfer pathway, P2; other site 572477008925 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 572477008926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477008927 S-adenosylmethionine binding site [chemical binding]; other site 572477008928 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 572477008929 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 572477008930 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 572477008931 P-loop; other site 572477008932 magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405 572477008933 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 572477008934 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 572477008935 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 572477008936 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 572477008937 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 572477008938 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 572477008939 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 572477008940 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 572477008941 transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040 572477008942 PAS domain; Region: PAS_8; pfam13188 572477008943 PAS domain; Region: PAS; smart00091 572477008944 putative active site [active] 572477008945 heme pocket [chemical binding]; other site 572477008946 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 572477008947 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 572477008948 UbiA prenyltransferase family; Region: UbiA; pfam01040 572477008949 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 572477008950 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 572477008951 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 572477008952 metal ion-dependent adhesion site (MIDAS); other site 572477008953 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572477008954 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572477008955 Walker A/P-loop; other site 572477008956 ATP binding site [chemical binding]; other site 572477008957 Q-loop/lid; other site 572477008958 ABC transporter signature motif; other site 572477008959 Walker B; other site 572477008960 D-loop; other site 572477008961 H-loop/switch region; other site 572477008962 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572477008963 FtsX-like permease family; Region: FtsX; pfam02687 572477008964 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 572477008965 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 572477008966 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 572477008967 protein binding site [polypeptide binding]; other site 572477008968 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 572477008969 Active site serine [active] 572477008970 CHASE3 domain; Region: CHASE3; cl05000 572477008971 Tetratricopeptide repeat; Region: TPR_16; pfam13432 572477008972 Phosphotransferase enzyme family; Region: APH; pfam01636 572477008973 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 572477008974 active site 572477008975 substrate binding site [chemical binding]; other site 572477008976 ATP binding site [chemical binding]; other site 572477008977 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 572477008978 HD domain; Region: HD_4; pfam13328 572477008979 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 572477008980 synthetase active site [active] 572477008981 NTP binding site [chemical binding]; other site 572477008982 metal binding site [ion binding]; metal-binding site 572477008983 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 572477008984 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 572477008985 Uncharacterized conserved protein [Function unknown]; Region: COG4198 572477008986 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 572477008987 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 572477008988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477008989 S-adenosylmethionine binding site [chemical binding]; other site 572477008990 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 572477008991 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 572477008992 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 572477008993 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 572477008994 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 572477008995 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 572477008996 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 572477008997 catalytic triad [active] 572477008998 PAS domain S-box; Region: sensory_box; TIGR00229 572477008999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477009000 putative active site [active] 572477009001 heme pocket [chemical binding]; other site 572477009002 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477009003 putative active site [active] 572477009004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477009005 heme pocket [chemical binding]; other site 572477009006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477009007 dimer interface [polypeptide binding]; other site 572477009008 phosphorylation site [posttranslational modification] 572477009009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477009010 ATP binding site [chemical binding]; other site 572477009011 Mg2+ binding site [ion binding]; other site 572477009012 G-X-G motif; other site 572477009013 Response regulator receiver domain; Region: Response_reg; pfam00072 572477009014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477009015 active site 572477009016 phosphorylation site [posttranslational modification] 572477009017 intermolecular recognition site; other site 572477009018 dimerization interface [polypeptide binding]; other site 572477009019 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 572477009020 Fe-S metabolism associated domain; Region: SufE; cl00951 572477009021 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 572477009022 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 572477009023 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 572477009024 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 572477009025 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 572477009026 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 572477009027 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572477009028 catalytic loop [active] 572477009029 iron binding site [ion binding]; other site 572477009030 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 572477009031 Nif-specific regulatory protein; Region: nifA; TIGR01817 572477009032 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 572477009033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477009034 Walker A motif; other site 572477009035 ATP binding site [chemical binding]; other site 572477009036 Walker B motif; other site 572477009037 arginine finger; other site 572477009038 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 572477009039 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 572477009040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477009041 putative active site [active] 572477009042 heme pocket [chemical binding]; other site 572477009043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477009044 ATP binding site [chemical binding]; other site 572477009045 Mg2+ binding site [ion binding]; other site 572477009046 G-X-G motif; other site 572477009047 electron transport complex protein RsxA; Provisional; Region: PRK05151 572477009048 electron transport complex protein RnfB; Provisional; Region: PRK05113 572477009049 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 572477009050 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 572477009051 SLBB domain; Region: SLBB; pfam10531 572477009052 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572477009053 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 572477009054 electron transport complex, RnfABCDGE type, G subunit; Region: rnfG; TIGR01947 572477009055 electron transport complex RsxE subunit; Provisional; Region: PRK12405 572477009056 RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658 572477009057 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 572477009058 PhoU domain; Region: PhoU; pfam01895 572477009059 PhoU domain; Region: PhoU; pfam01895 572477009060 Domain of unknown function (DUF389); Region: DUF389; cl00781 572477009061 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 572477009062 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 572477009063 Transporter associated domain; Region: CorC_HlyC; smart01091 572477009064 metal-binding heat shock protein; Provisional; Region: PRK00016 572477009065 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 572477009066 PhoH-like protein; Region: PhoH; pfam02562 572477009067 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 572477009068 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 572477009069 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477009070 FeS/SAM binding site; other site 572477009071 TRAM domain; Region: TRAM; pfam01938 572477009072 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 572477009073 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; pfam01184 572477009074 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 572477009075 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 572477009076 G1 box; other site 572477009077 putative GEF interaction site [polypeptide binding]; other site 572477009078 GTP/Mg2+ binding site [chemical binding]; other site 572477009079 Switch I region; other site 572477009080 G2 box; other site 572477009081 G3 box; other site 572477009082 Switch II region; other site 572477009083 G4 box; other site 572477009084 G5 box; other site 572477009085 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 572477009086 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 572477009087 MoxR-like ATPases [General function prediction only]; Region: COG0714 572477009088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477009089 Walker A motif; other site 572477009090 ATP binding site [chemical binding]; other site 572477009091 Walker B motif; other site 572477009092 arginine finger; other site 572477009093 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 572477009094 active site 572477009095 homotetramer interface [polypeptide binding]; other site 572477009096 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 572477009097 Protein of unknown function DUF58; Region: DUF58; pfam01882 572477009098 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 572477009099 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 572477009100 metal ion-dependent adhesion site (MIDAS); other site 572477009101 von Willebrand factor type A domain; Region: VWA_2; pfam13519 572477009102 metal ion-dependent adhesion site (MIDAS); other site 572477009103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572477009104 binding surface 572477009105 Tetratricopeptide repeat; Region: TPR_16; pfam13432 572477009106 TPR motif; other site 572477009107 Oxygen tolerance; Region: BatD; pfam13584 572477009108 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 572477009109 Transglycosylase; Region: Transgly; cl17702 572477009110 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 572477009111 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 572477009112 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 572477009113 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572477009114 catalytic core [active] 572477009115 Hemerythrin; Region: Hemerythrin; cd12107 572477009116 Fe binding site [ion binding]; other site 572477009117 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 572477009118 nucleoside/Zn binding site; other site 572477009119 dimer interface [polypeptide binding]; other site 572477009120 catalytic motif [active] 572477009121 GMP synthase; Reviewed; Region: guaA; PRK00074 572477009122 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 572477009123 AMP/PPi binding site [chemical binding]; other site 572477009124 candidate oxyanion hole; other site 572477009125 catalytic triad [active] 572477009126 potential glutamine specificity residues [chemical binding]; other site 572477009127 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 572477009128 ATP Binding subdomain [chemical binding]; other site 572477009129 Ligand Binding sites [chemical binding]; other site 572477009130 Dimerization subdomain; other site 572477009131 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 572477009132 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 572477009133 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 572477009134 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 572477009135 active site 572477009136 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 572477009137 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 572477009138 generic binding surface II; other site 572477009139 generic binding surface I; other site 572477009140 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 572477009141 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572477009142 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572477009143 ABC transporter; Region: ABC_tran_2; pfam12848 572477009144 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572477009145 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 572477009146 homodimer interface [polypeptide binding]; other site 572477009147 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 572477009148 active site pocket [active] 572477009149 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 572477009150 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 572477009151 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 572477009152 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 572477009153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572477009154 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 572477009155 putative acyl-acceptor binding pocket; other site 572477009156 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572477009157 acyl-activating enzyme (AAE) consensus motif; other site 572477009158 active site 572477009159 AMP binding site [chemical binding]; other site 572477009160 CoA binding site [chemical binding]; other site 572477009161 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572477009162 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 572477009163 putative ADP-binding pocket [chemical binding]; other site 572477009164 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 572477009165 TPR repeat; Region: TPR_11; pfam13414 572477009166 OsmC-like protein; Region: OsmC; cl00767 572477009167 intracellular protease, PfpI family; Region: PfpI; TIGR01382 572477009168 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 572477009169 conserved cys residue [active] 572477009170 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 572477009171 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 572477009172 quinone interaction residues [chemical binding]; other site 572477009173 active site 572477009174 catalytic residues [active] 572477009175 FMN binding site [chemical binding]; other site 572477009176 substrate binding site [chemical binding]; other site 572477009177 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 572477009178 active site 572477009179 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 572477009180 dimer interface [polypeptide binding]; other site 572477009181 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 572477009182 Ligand Binding Site [chemical binding]; other site 572477009183 Molecular Tunnel; other site 572477009184 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 572477009185 glycogen branching enzyme; Provisional; Region: PRK05402 572477009186 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 572477009187 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 572477009188 active site 572477009189 catalytic site [active] 572477009190 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 572477009191 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 572477009192 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 572477009193 ligand binding site; other site 572477009194 oligomer interface; other site 572477009195 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 572477009196 dimer interface [polypeptide binding]; other site 572477009197 N-terminal domain interface [polypeptide binding]; other site 572477009198 sulfate 1 binding site; other site 572477009199 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 572477009200 thiS-thiF/thiG interaction site; other site 572477009201 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 572477009202 ThiS interaction site; other site 572477009203 putative active site [active] 572477009204 tetramer interface [polypeptide binding]; other site 572477009205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477009206 S-adenosylmethionine binding site [chemical binding]; other site 572477009207 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 572477009208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477009209 Walker A/P-loop; other site 572477009210 ATP binding site [chemical binding]; other site 572477009211 Q-loop/lid; other site 572477009212 ABC transporter signature motif; other site 572477009213 Walker B; other site 572477009214 D-loop; other site 572477009215 H-loop/switch region; other site 572477009216 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 572477009217 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 572477009218 Predicted dehydrogenase [General function prediction only]; Region: COG0579 572477009219 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 572477009220 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 572477009221 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 572477009222 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 572477009223 NAD binding site [chemical binding]; other site 572477009224 substrate binding site [chemical binding]; other site 572477009225 homodimer interface [polypeptide binding]; other site 572477009226 active site 572477009227 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 572477009228 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 572477009229 substrate binding site; other site 572477009230 tetramer interface; other site 572477009231 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 572477009232 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 572477009233 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 572477009234 NADP binding site [chemical binding]; other site 572477009235 active site 572477009236 putative substrate binding site [chemical binding]; other site 572477009237 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 572477009238 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 572477009239 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 572477009240 active site 572477009241 dimer interface [polypeptide binding]; other site 572477009242 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 572477009243 dimer interface [polypeptide binding]; other site 572477009244 active site 572477009245 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572477009246 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572477009247 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 572477009248 putative dimerization interface [polypeptide binding]; other site 572477009249 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 572477009250 aromatic arch; other site 572477009251 DCoH dimer interaction site [polypeptide binding]; other site 572477009252 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 572477009253 DCoH tetramer interaction site [polypeptide binding]; other site 572477009254 substrate binding site [chemical binding]; other site 572477009255 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 572477009256 Ferritin-like domain; Region: Ferritin; pfam00210 572477009257 dinuclear metal binding motif [ion binding]; other site 572477009258 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 572477009259 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 572477009260 Hexamer interface [polypeptide binding]; other site 572477009261 Hexagonal pore residue; other site 572477009262 Hexagonal pore; other site 572477009263 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 572477009264 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 572477009265 Hexamer interface [polypeptide binding]; other site 572477009266 Hexagonal pore residue; other site 572477009267 Hexagonal pore; other site 572477009268 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 572477009269 Hexamer/Pentamer interface [polypeptide binding]; other site 572477009270 central pore; other site 572477009271 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 572477009272 Hexamer/Pentamer interface [polypeptide binding]; other site 572477009273 central pore; other site 572477009274 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936 572477009275 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 572477009276 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 572477009277 multimerization interface [polypeptide binding]; other site 572477009278 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 572477009279 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 572477009280 dimer interface [polypeptide binding]; other site 572477009281 catalytic residue [active] 572477009282 metal binding site [ion binding]; metal-binding site 572477009283 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cl01843 572477009284 putative multimerization interface [polypeptide binding]; other site 572477009285 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 572477009286 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 572477009287 Sulfate transporter family; Region: Sulfate_transp; pfam00916 572477009288 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 572477009289 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 572477009290 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 572477009291 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 572477009292 glycogen synthase; Provisional; Region: glgA; PRK00654 572477009293 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 572477009294 ADP-binding pocket [chemical binding]; other site 572477009295 homodimer interface [polypeptide binding]; other site 572477009296 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 572477009297 tetramerization interface [polypeptide binding]; other site 572477009298 active site 572477009299 Pantoate-beta-alanine ligase; Region: PanC; cd00560 572477009300 pantoate--beta-alanine ligase; Region: panC; TIGR00018 572477009301 active site 572477009302 ATP-binding site [chemical binding]; other site 572477009303 pantoate-binding site; other site 572477009304 HXXH motif; other site 572477009305 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 572477009306 oligomerization interface [polypeptide binding]; other site 572477009307 active site 572477009308 metal binding site [ion binding]; metal-binding site 572477009309 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 572477009310 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 572477009311 active site 572477009312 NTP binding site [chemical binding]; other site 572477009313 metal binding triad [ion binding]; metal-binding site 572477009314 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 572477009315 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 572477009316 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 572477009317 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 572477009318 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 572477009319 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 572477009320 active site 572477009321 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 572477009322 active site 572477009323 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 572477009324 active site 572477009325 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 572477009326 Ligand Binding Site [chemical binding]; other site 572477009327 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 572477009328 Cytochrome C' Region: Cytochrom_C_2; pfam01322 572477009329 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 572477009330 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 572477009331 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 572477009332 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 572477009333 ATP binding site [chemical binding]; other site 572477009334 Mg++ binding site [ion binding]; other site 572477009335 motif III; other site 572477009336 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572477009337 nucleotide binding region [chemical binding]; other site 572477009338 ATP-binding site [chemical binding]; other site 572477009339 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 572477009340 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 572477009341 hybrid cluster protein; Provisional; Region: PRK05290 572477009342 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572477009343 ACS interaction site; other site 572477009344 CODH interaction site; other site 572477009345 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 572477009346 hybrid metal cluster; other site 572477009347 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 572477009348 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 572477009349 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 572477009350 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 572477009351 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 572477009352 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 572477009353 homodimer interface [polypeptide binding]; other site 572477009354 metal binding site [ion binding]; metal-binding site 572477009355 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 572477009356 homodimer interface [polypeptide binding]; other site 572477009357 active site 572477009358 putative chemical substrate binding site [chemical binding]; other site 572477009359 metal binding site [ion binding]; metal-binding site 572477009360 SWIM zinc finger; Region: SWIM; pfam04434 572477009361 MoxR-like ATPases [General function prediction only]; Region: COG0714 572477009362 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 572477009363 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 572477009364 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 572477009365 metal ion-dependent adhesion site (MIDAS); other site 572477009366 OpgC protein; Region: OpgC_C; cl17858 572477009367 CHAD domain; Region: CHAD; pfam05235 572477009368 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477009369 dimerization interface [polypeptide binding]; other site 572477009370 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572477009371 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477009372 dimer interface [polypeptide binding]; other site 572477009373 putative CheW interface [polypeptide binding]; other site 572477009374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572477009375 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572477009376 putative substrate translocation pore; other site 572477009377 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 572477009378 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 572477009379 dimer interface [polypeptide binding]; other site 572477009380 ssDNA binding site [nucleotide binding]; other site 572477009381 tetramer (dimer of dimers) interface [polypeptide binding]; other site 572477009382 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572477009383 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572477009384 non-specific DNA binding site [nucleotide binding]; other site 572477009385 salt bridge; other site 572477009386 sequence-specific DNA binding site [nucleotide binding]; other site 572477009387 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 572477009388 putative active site [active] 572477009389 putative NTP binding site [chemical binding]; other site 572477009390 putative nucleic acid binding site [nucleotide binding]; other site 572477009391 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 572477009392 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 572477009393 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 572477009394 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 572477009395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477009396 Walker A motif; other site 572477009397 ATP binding site [chemical binding]; other site 572477009398 Walker B motif; other site 572477009399 arginine finger; other site 572477009400 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 572477009401 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 572477009402 active site 572477009403 catalytic triad [active] 572477009404 Divergent AAA domain; Region: AAA_4; pfam04326 572477009405 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 572477009406 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 572477009407 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 572477009408 GatB domain; Region: GatB_Yqey; smart00845 572477009409 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 572477009410 putative active site pocket [active] 572477009411 4-fold oligomerization interface [polypeptide binding]; other site 572477009412 metal binding residues [ion binding]; metal-binding site 572477009413 3-fold/trimer interface [polypeptide binding]; other site 572477009414 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 572477009415 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 572477009416 catalytic residues [active] 572477009417 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 572477009418 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 572477009419 metal binding site [ion binding]; metal-binding site 572477009420 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 572477009421 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 572477009422 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572477009423 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572477009424 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 572477009425 dimerization interface [polypeptide binding]; other site 572477009426 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572477009427 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572477009428 non-specific DNA binding site [nucleotide binding]; other site 572477009429 salt bridge; other site 572477009430 sequence-specific DNA binding site [nucleotide binding]; other site 572477009431 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 572477009432 dimerization interface [polypeptide binding]; other site 572477009433 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 572477009434 ATP binding site [chemical binding]; other site 572477009435 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 572477009436 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 572477009437 HupF/HypC family; Region: HupF_HypC; pfam01455 572477009438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 572477009439 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 572477009440 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 572477009441 catalytic triad [active] 572477009442 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477009443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477009444 dimer interface [polypeptide binding]; other site 572477009445 phosphorylation site [posttranslational modification] 572477009446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477009447 ATP binding site [chemical binding]; other site 572477009448 Mg2+ binding site [ion binding]; other site 572477009449 G-X-G motif; other site 572477009450 Response regulator receiver domain; Region: Response_reg; pfam00072 572477009451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 572477009452 active site 572477009453 phosphorylation site [posttranslational modification] 572477009454 intermolecular recognition site; other site 572477009455 dimerization interface [polypeptide binding]; other site 572477009456 Response regulator receiver domain; Region: Response_reg; pfam00072 572477009457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477009458 active site 572477009459 phosphorylation site [posttranslational modification] 572477009460 intermolecular recognition site; other site 572477009461 dimerization interface [polypeptide binding]; other site 572477009462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477009463 PAS domain; Region: PAS_9; pfam13426 572477009464 putative active site [active] 572477009465 heme pocket [chemical binding]; other site 572477009466 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572477009467 dimerization interface [polypeptide binding]; other site 572477009468 putative DNA binding site [nucleotide binding]; other site 572477009469 putative Zn2+ binding site [ion binding]; other site 572477009470 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477009471 dimer interface [polypeptide binding]; other site 572477009472 putative CheW interface [polypeptide binding]; other site 572477009473 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 572477009474 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 572477009475 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 572477009476 chorismate binding enzyme; Region: Chorismate_bind; cl10555 572477009477 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 572477009478 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 572477009479 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 572477009480 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 572477009481 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 572477009482 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 572477009483 active site 572477009484 substrate binding site [chemical binding]; other site 572477009485 metal binding site [ion binding]; metal-binding site 572477009486 GH3 auxin-responsive promoter; Region: GH3; pfam03321 572477009487 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 572477009488 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 572477009489 active site 572477009490 nucleophile elbow; other site 572477009491 Transmembrane secretion effector; Region: MFS_3; pfam05977 572477009492 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572477009493 GH3 auxin-responsive promoter; Region: GH3; pfam03321 572477009494 hypothetical protein; Provisional; Region: PRK01254 572477009495 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 572477009496 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 572477009497 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 572477009498 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 572477009499 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 572477009500 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 572477009501 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 572477009502 ligand binding site [chemical binding]; other site 572477009503 PilZ domain; Region: PilZ; pfam07238 572477009504 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 572477009505 Protein export membrane protein; Region: SecD_SecF; cl14618 572477009506 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 572477009507 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 572477009508 HlyD family secretion protein; Region: HlyD_3; pfam13437 572477009509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572477009510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572477009511 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 572477009512 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 572477009513 HAMP domain; Region: HAMP; pfam00672 572477009514 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572477009515 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477009516 dimer interface [polypeptide binding]; other site 572477009517 putative CheW interface [polypeptide binding]; other site 572477009518 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 572477009519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477009520 S-adenosylmethionine binding site [chemical binding]; other site 572477009521 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 572477009522 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 572477009523 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 572477009524 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572477009525 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 572477009526 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572477009527 Coenzyme A binding pocket [chemical binding]; other site 572477009528 Peptidase_C39 like family; Region: DUF3335; pfam11814 572477009529 acetylornithine deacetylase; Provisional; Region: PRK05111 572477009530 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 572477009531 metal binding site [ion binding]; metal-binding site 572477009532 putative dimer interface [polypeptide binding]; other site 572477009533 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 572477009534 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572477009535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477009536 homodimer interface [polypeptide binding]; other site 572477009537 catalytic residue [active] 572477009538 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 572477009539 histidinol dehydrogenase; Region: hisD; TIGR00069 572477009540 NAD binding site [chemical binding]; other site 572477009541 dimerization interface [polypeptide binding]; other site 572477009542 product binding site; other site 572477009543 substrate binding site [chemical binding]; other site 572477009544 zinc binding site [ion binding]; other site 572477009545 catalytic residues [active] 572477009546 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 572477009547 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 572477009548 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 572477009549 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 572477009550 hinge; other site 572477009551 active site 572477009552 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 572477009553 anti sigma factor interaction site; other site 572477009554 regulatory phosphorylation site [posttranslational modification]; other site 572477009555 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 572477009556 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 572477009557 mce related protein; Region: MCE; pfam02470 572477009558 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 572477009559 Permease; Region: Permease; pfam02405 572477009560 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 572477009561 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 572477009562 Walker A/P-loop; other site 572477009563 ATP binding site [chemical binding]; other site 572477009564 Q-loop/lid; other site 572477009565 ABC transporter signature motif; other site 572477009566 Walker B; other site 572477009567 D-loop; other site 572477009568 H-loop/switch region; other site 572477009569 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 572477009570 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 572477009571 putative active site [active] 572477009572 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 572477009573 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 572477009574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572477009575 active site 572477009576 motif I; other site 572477009577 motif II; other site 572477009578 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 572477009579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 572477009580 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 572477009581 OstA-like protein; Region: OstA; pfam03968 572477009582 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 572477009583 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 572477009584 Walker A/P-loop; other site 572477009585 ATP binding site [chemical binding]; other site 572477009586 Q-loop/lid; other site 572477009587 ABC transporter signature motif; other site 572477009588 Walker B; other site 572477009589 D-loop; other site 572477009590 H-loop/switch region; other site 572477009591 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 572477009592 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 572477009593 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 572477009594 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 572477009595 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 572477009596 30S subunit binding site; other site 572477009597 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 572477009598 active site 572477009599 phosphorylation site [posttranslational modification] 572477009600 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 572477009601 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 572477009602 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 572477009603 Hpr binding site; other site 572477009604 active site 572477009605 homohexamer subunit interaction site [polypeptide binding]; other site 572477009606 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 572477009607 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 572477009608 active pocket/dimerization site; other site 572477009609 active site 572477009610 phosphorylation site [posttranslational modification] 572477009611 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 572477009612 dimerization domain swap beta strand [polypeptide binding]; other site 572477009613 regulatory protein interface [polypeptide binding]; other site 572477009614 active site 572477009615 regulatory phosphorylation site [posttranslational modification]; other site 572477009616 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 572477009617 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 572477009618 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 572477009619 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 572477009620 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 572477009621 MgtE intracellular N domain; Region: MgtE_N; smart00924 572477009622 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 572477009623 Divalent cation transporter; Region: MgtE; cl00786 572477009624 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 572477009625 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 572477009626 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 572477009627 rod shape-determining protein MreB; Provisional; Region: PRK13927 572477009628 MreB and similar proteins; Region: MreB_like; cd10225 572477009629 nucleotide binding site [chemical binding]; other site 572477009630 Mg binding site [ion binding]; other site 572477009631 putative protofilament interaction site [polypeptide binding]; other site 572477009632 RodZ interaction site [polypeptide binding]; other site 572477009633 rod shape-determining protein MreC; Provisional; Region: PRK13922 572477009634 Protein of unknown function (DUF972); Region: DUF972; pfam06156 572477009635 rod shape-determining protein MreC; Region: MreC; pfam04085 572477009636 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 572477009637 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 572477009638 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572477009639 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572477009640 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 572477009641 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 572477009642 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 572477009643 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 572477009644 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 572477009645 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 572477009646 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 572477009647 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 572477009648 homodimer interface [polypeptide binding]; other site 572477009649 substrate-cofactor binding pocket; other site 572477009650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477009651 catalytic residue [active] 572477009652 Protein of unknown function (DUF493); Region: DUF493; pfam04359 572477009653 lipoate-protein ligase B; Provisional; Region: PRK14342 572477009654 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572477009655 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572477009656 substrate binding pocket [chemical binding]; other site 572477009657 membrane-bound complex binding site; other site 572477009658 hinge residues; other site 572477009659 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572477009660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477009661 putative active site [active] 572477009662 heme pocket [chemical binding]; other site 572477009663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477009664 dimer interface [polypeptide binding]; other site 572477009665 phosphorylation site [posttranslational modification] 572477009666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477009667 ATP binding site [chemical binding]; other site 572477009668 Mg2+ binding site [ion binding]; other site 572477009669 G-X-G motif; other site 572477009670 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 572477009671 active site 572477009672 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 572477009673 putative active site [active] 572477009674 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572477009675 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572477009676 substrate binding pocket [chemical binding]; other site 572477009677 membrane-bound complex binding site; other site 572477009678 hinge residues; other site 572477009679 PAS domain; Region: PAS_9; pfam13426 572477009680 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477009681 putative active site [active] 572477009682 heme pocket [chemical binding]; other site 572477009683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477009684 PAS fold; Region: PAS_3; pfam08447 572477009685 putative active site [active] 572477009686 heme pocket [chemical binding]; other site 572477009687 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477009688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477009689 dimer interface [polypeptide binding]; other site 572477009690 phosphorylation site [posttranslational modification] 572477009691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477009692 ATP binding site [chemical binding]; other site 572477009693 Mg2+ binding site [ion binding]; other site 572477009694 G-X-G motif; other site 572477009695 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477009696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477009697 active site 572477009698 phosphorylation site [posttranslational modification] 572477009699 intermolecular recognition site; other site 572477009700 dimerization interface [polypeptide binding]; other site 572477009701 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572477009702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477009703 active site 572477009704 phosphorylation site [posttranslational modification] 572477009705 intermolecular recognition site; other site 572477009706 dimerization interface [polypeptide binding]; other site 572477009707 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 572477009708 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 572477009709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477009710 active site 572477009711 phosphorylation site [posttranslational modification] 572477009712 intermolecular recognition site; other site 572477009713 dimerization interface [polypeptide binding]; other site 572477009714 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572477009715 Zn2+ binding site [ion binding]; other site 572477009716 Mg2+ binding site [ion binding]; other site 572477009717 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 572477009718 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 572477009719 Cu(I) binding site [ion binding]; other site 572477009720 Protein of unknown function (DUF461); Region: DUF461; pfam04314 572477009721 Cytochrome c553 [Energy production and conversion]; Region: COG2863 572477009722 Cytochrome c; Region: Cytochrom_C; cl11414 572477009723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572477009724 putative substrate translocation pore; other site 572477009725 PAS fold; Region: PAS; pfam00989 572477009726 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477009727 putative active site [active] 572477009728 heme pocket [chemical binding]; other site 572477009729 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477009730 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477009731 metal binding site [ion binding]; metal-binding site 572477009732 active site 572477009733 I-site; other site 572477009734 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477009735 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 572477009736 CheB methylesterase; Region: CheB_methylest; pfam01339 572477009737 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 572477009738 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 572477009739 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 572477009740 PAS domain; Region: PAS_10; pfam13596 572477009741 PAS fold; Region: PAS_4; pfam08448 572477009742 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572477009743 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 572477009744 active site 572477009745 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 572477009746 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 572477009747 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 572477009748 active site 572477009749 (T/H)XGH motif; other site 572477009750 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 572477009751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477009752 S-adenosylmethionine binding site [chemical binding]; other site 572477009753 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 572477009754 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 572477009755 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 572477009756 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 572477009757 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 572477009758 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 572477009759 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 572477009760 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 572477009761 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 572477009762 P loop; other site 572477009763 GTP binding site [chemical binding]; other site 572477009764 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 572477009765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572477009766 Walker A/P-loop; other site 572477009767 ATP binding site [chemical binding]; other site 572477009768 Q-loop/lid; other site 572477009769 ABC transporter signature motif; other site 572477009770 Walker B; other site 572477009771 D-loop; other site 572477009772 H-loop/switch region; other site 572477009773 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 572477009774 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 572477009775 putative catalytic site [active] 572477009776 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 572477009777 putative metal binding site [ion binding]; other site 572477009778 putative phosphate binding site [ion binding]; other site 572477009779 putative catalytic site [active] 572477009780 putative phosphate binding site [ion binding]; other site 572477009781 putative metal binding site [ion binding]; other site 572477009782 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 572477009783 YGGT family; Region: YGGT; pfam02325 572477009784 YGGT family; Region: YGGT; pfam02325 572477009785 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 572477009786 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 572477009787 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 572477009788 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572477009789 catalytic residue [active] 572477009790 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 572477009791 active site 572477009792 dimerization interface [polypeptide binding]; other site 572477009793 ribonuclease PH; Reviewed; Region: rph; PRK00173 572477009794 Ribonuclease PH; Region: RNase_PH_bact; cd11362 572477009795 hexamer interface [polypeptide binding]; other site 572477009796 active site 572477009797 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 572477009798 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 572477009799 eyelet of channel; other site 572477009800 trimer interface [polypeptide binding]; other site 572477009801 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 572477009802 tetramer (dimer of dimers) interface [polypeptide binding]; other site 572477009803 active site 572477009804 dimer interface [polypeptide binding]; other site 572477009805 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 572477009806 Cell division protein ZapA; Region: ZapA; pfam05164 572477009807 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 572477009808 proline aminopeptidase P II; Provisional; Region: PRK10879 572477009809 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 572477009810 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 572477009811 active site 572477009812 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 572477009813 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 572477009814 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 572477009815 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 572477009816 6-phosphofructokinase; Provisional; Region: PRK14072 572477009817 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 572477009818 active site 572477009819 ADP/pyrophosphate binding site [chemical binding]; other site 572477009820 dimerization interface [polypeptide binding]; other site 572477009821 allosteric effector site; other site 572477009822 fructose-1,6-bisphosphate binding site; other site 572477009823 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 572477009824 dimer interface [polypeptide binding]; other site 572477009825 substrate binding site [chemical binding]; other site 572477009826 metal binding sites [ion binding]; metal-binding site 572477009827 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 572477009828 trimer interface [polypeptide binding]; other site 572477009829 dimer interface [polypeptide binding]; other site 572477009830 putative active site [active] 572477009831 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 572477009832 G1 box; other site 572477009833 GTP/Mg2+ binding site [chemical binding]; other site 572477009834 Switch I region; other site 572477009835 G2 box; other site 572477009836 G3 box; other site 572477009837 Switch II region; other site 572477009838 G4 box; other site 572477009839 G5 box; other site 572477009840 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477009841 PAS fold; Region: PAS_3; pfam08447 572477009842 putative active site [active] 572477009843 heme pocket [chemical binding]; other site 572477009844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477009845 PAS domain; Region: PAS_9; pfam13426 572477009846 putative active site [active] 572477009847 heme pocket [chemical binding]; other site 572477009848 PAS domain S-box; Region: sensory_box; TIGR00229 572477009849 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477009850 putative active site [active] 572477009851 heme pocket [chemical binding]; other site 572477009852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477009853 dimer interface [polypeptide binding]; other site 572477009854 phosphorylation site [posttranslational modification] 572477009855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477009856 ATP binding site [chemical binding]; other site 572477009857 Mg2+ binding site [ion binding]; other site 572477009858 G-X-G motif; other site 572477009859 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 572477009860 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 572477009861 putative CheA interaction surface; other site 572477009862 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 572477009863 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 572477009864 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 572477009865 ligand binding site [chemical binding]; other site 572477009866 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 572477009867 flagellar motor protein; Reviewed; Region: motC; PRK09109 572477009868 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 572477009869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477009870 active site 572477009871 phosphorylation site [posttranslational modification] 572477009872 intermolecular recognition site; other site 572477009873 dimerization interface [polypeptide binding]; other site 572477009874 CheB methylesterase; Region: CheB_methylest; pfam01339 572477009875 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572477009876 putative binding surface; other site 572477009877 active site 572477009878 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 572477009879 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 572477009880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477009881 ATP binding site [chemical binding]; other site 572477009882 Mg2+ binding site [ion binding]; other site 572477009883 G-X-G motif; other site 572477009884 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 572477009885 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 572477009886 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 572477009887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477009888 active site 572477009889 phosphorylation site [posttranslational modification] 572477009890 intermolecular recognition site; other site 572477009891 dimerization interface [polypeptide binding]; other site 572477009892 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 572477009893 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572477009894 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 572477009895 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572477009896 DNA binding residues [nucleotide binding] 572477009897 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 572477009898 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 572477009899 P-loop; other site 572477009900 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 572477009901 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572477009902 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 572477009903 FHIPEP family; Region: FHIPEP; pfam00771 572477009904 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 572477009905 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 572477009906 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 572477009907 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 572477009908 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 572477009909 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 572477009910 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 572477009911 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 572477009912 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 572477009913 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 572477009914 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 572477009915 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 572477009916 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 572477009917 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 572477009918 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 572477009919 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 572477009920 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 572477009921 Walker A motif/ATP binding site; other site 572477009922 Walker B motif; other site 572477009923 Flagellar assembly protein FliH; Region: FliH; pfam02108 572477009924 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 572477009925 MgtE intracellular N domain; Region: MgtE_N; smart00924 572477009926 FliG C-terminal domain; Region: FliG_C; pfam01706 572477009927 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 572477009928 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 572477009929 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 572477009930 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 572477009931 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 572477009932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477009933 Walker A motif; other site 572477009934 ATP binding site [chemical binding]; other site 572477009935 Walker B motif; other site 572477009936 arginine finger; other site 572477009937 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 572477009938 Late competence development protein ComFB; Region: ComFB; pfam10719 572477009939 HDOD domain; Region: HDOD; pfam08668 572477009940 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 572477009941 flagellar motor protein MotA; Validated; Region: PRK09110 572477009942 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 572477009943 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 572477009944 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 572477009945 ligand binding site [chemical binding]; other site 572477009946 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 572477009947 putative dimer interface [polypeptide binding]; other site 572477009948 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572477009949 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 572477009950 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 572477009951 ligand binding site [chemical binding]; other site 572477009952 PIN domain; Region: PIN_3; pfam13470 572477009953 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 572477009954 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 572477009955 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 572477009956 Domain of unknown function (DUF4201); Region: DUF4201; pfam13870 572477009957 AAA domain; Region: AAA_11; pfam13086 572477009958 Part of AAA domain; Region: AAA_19; pfam13245 572477009959 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 572477009960 AAA domain; Region: AAA_12; pfam13087 572477009961 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 572477009962 putative active site [active] 572477009963 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 572477009964 Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945 572477009965 active site 572477009966 catalytic residues [active] 572477009967 metal binding site [ion binding]; metal-binding site 572477009968 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 572477009969 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 572477009970 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 572477009971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572477009972 catalytic residue [active] 572477009973 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 572477009974 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 572477009975 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 572477009976 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 572477009977 Na binding site [ion binding]; other site 572477009978 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 572477009979 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 572477009980 putative active site [active] 572477009981 putative NTP binding site [chemical binding]; other site 572477009982 putative nucleic acid binding site [nucleotide binding]; other site 572477009983 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 572477009984 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477009985 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477009986 metal binding site [ion binding]; metal-binding site 572477009987 active site 572477009988 I-site; other site 572477009989 elongation factor G; Reviewed; Region: PRK12739 572477009990 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 572477009991 G1 box; other site 572477009992 GTP/Mg2+ binding site [chemical binding]; other site 572477009993 G2 box; other site 572477009994 Switch I region; other site 572477009995 G3 box; other site 572477009996 Switch II region; other site 572477009997 G4 box; other site 572477009998 G5 box; other site 572477009999 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 572477010000 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 572477010001 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 572477010002 L,D-transpeptidase; Provisional; Region: PRK10190 572477010003 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 572477010004 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572477010005 Chorismate lyase; Region: Chor_lyase; cl01230 572477010006 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 572477010007 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 572477010008 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 572477010009 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 572477010010 Walker A/P-loop; other site 572477010011 ATP binding site [chemical binding]; other site 572477010012 Q-loop/lid; other site 572477010013 ABC transporter signature motif; other site 572477010014 Walker B; other site 572477010015 D-loop; other site 572477010016 H-loop/switch region; other site 572477010017 FOG: CBS domain [General function prediction only]; Region: COG0517 572477010018 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 572477010019 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 572477010020 metal binding triad; other site 572477010021 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 572477010022 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 572477010023 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 572477010024 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 572477010025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 572477010026 SCP-2 sterol transfer family; Region: SCP2; pfam02036 572477010027 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 572477010028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477010029 S-adenosylmethionine binding site [chemical binding]; other site 572477010030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 572477010031 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 572477010032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477010033 Walker A motif; other site 572477010034 ATP binding site [chemical binding]; other site 572477010035 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 572477010036 Walker B motif; other site 572477010037 arginine finger; other site 572477010038 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 572477010039 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 572477010040 active site 572477010041 HslU subunit interaction site [polypeptide binding]; other site 572477010042 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 572477010043 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572477010044 Zn2+ binding site [ion binding]; other site 572477010045 Mg2+ binding site [ion binding]; other site 572477010046 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 572477010047 synthetase active site [active] 572477010048 NTP binding site [chemical binding]; other site 572477010049 metal binding site [ion binding]; metal-binding site 572477010050 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 572477010051 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 572477010052 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 572477010053 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 572477010054 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 572477010055 catalytic site [active] 572477010056 G-X2-G-X-G-K; other site 572477010057 hypothetical protein; Provisional; Region: PRK11820 572477010058 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 572477010059 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 572477010060 Protein kinase domain; Region: Pkinase; pfam00069 572477010061 Catalytic domain of Protein Kinases; Region: PKc; cd00180 572477010062 active site 572477010063 ATP binding site [chemical binding]; other site 572477010064 substrate binding site [chemical binding]; other site 572477010065 activation loop (A-loop); other site 572477010066 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 572477010067 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 572477010068 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572477010069 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572477010070 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 572477010071 dimerization interface [polypeptide binding]; other site 572477010072 azoreductase; Reviewed; Region: PRK00170 572477010073 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 572477010074 Pirin-related protein [General function prediction only]; Region: COG1741 572477010075 Pirin; Region: Pirin; pfam02678 572477010076 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 572477010077 hypothetical protein; Reviewed; Region: PRK00024 572477010078 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 572477010079 MPN+ (JAMM) motif; other site 572477010080 Zinc-binding site [ion binding]; other site 572477010081 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 572477010082 Flavoprotein; Region: Flavoprotein; pfam02441 572477010083 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 572477010084 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 572477010085 trimer interface [polypeptide binding]; other site 572477010086 active site 572477010087 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477010088 dimerization interface [polypeptide binding]; other site 572477010089 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572477010090 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477010091 dimer interface [polypeptide binding]; other site 572477010092 putative CheW interface [polypeptide binding]; other site 572477010093 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 572477010094 feedback inhibition sensing region; other site 572477010095 homohexameric interface [polypeptide binding]; other site 572477010096 nucleotide binding site [chemical binding]; other site 572477010097 N-acetyl-L-glutamate binding site [chemical binding]; other site 572477010098 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 572477010099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477010100 active site 572477010101 phosphorylation site [posttranslational modification] 572477010102 intermolecular recognition site; other site 572477010103 dimerization interface [polypeptide binding]; other site 572477010104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477010105 Walker A motif; other site 572477010106 ATP binding site [chemical binding]; other site 572477010107 Walker B motif; other site 572477010108 arginine finger; other site 572477010109 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 572477010110 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 572477010111 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477010112 putative active site [active] 572477010113 heme pocket [chemical binding]; other site 572477010114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477010115 dimer interface [polypeptide binding]; other site 572477010116 phosphorylation site [posttranslational modification] 572477010117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477010118 ATP binding site [chemical binding]; other site 572477010119 G-X-G motif; other site 572477010120 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 572477010121 glutamine synthetase; Provisional; Region: glnA; PRK09469 572477010122 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 572477010123 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 572477010124 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 572477010125 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 572477010126 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 572477010127 dimer interface [polypeptide binding]; other site 572477010128 motif 1; other site 572477010129 active site 572477010130 motif 2; other site 572477010131 motif 3; other site 572477010132 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 572477010133 DALR anticodon binding domain; Region: DALR_1; smart00836 572477010134 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 572477010135 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572477010136 active site 572477010137 motif I; other site 572477010138 motif II; other site 572477010139 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 572477010140 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 572477010141 putative acyl-acceptor binding pocket; other site 572477010142 type II secretion system protein D; Region: type_II_gspD; TIGR02517 572477010143 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 572477010144 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 572477010145 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 572477010146 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 572477010147 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 572477010148 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 572477010149 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 572477010150 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 572477010151 general secretion pathway protein J; Validated; Region: PRK08808 572477010152 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 572477010153 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 572477010154 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 572477010155 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 572477010156 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 572477010157 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 572477010158 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 572477010159 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 572477010160 Type II transport protein GspH; Region: GspH; pfam12019 572477010161 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 572477010162 PilX N-terminal; Region: PilX_N; pfam14341 572477010163 von Willebrand factor type A domain; Region: VWA_2; pfam13519 572477010164 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 572477010165 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 572477010166 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 572477010167 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 572477010168 type II secretion system protein E; Region: type_II_gspE; TIGR02533 572477010169 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 572477010170 Walker A motif; other site 572477010171 ATP binding site [chemical binding]; other site 572477010172 Walker B motif; other site 572477010173 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 572477010174 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 572477010175 Mg++ binding site [ion binding]; other site 572477010176 putative catalytic motif [active] 572477010177 putative substrate binding site [chemical binding]; other site 572477010178 DJ-1 family protein; Region: not_thiJ; TIGR01383 572477010179 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 572477010180 conserved cys residue [active] 572477010181 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 572477010182 C-terminal peptidase (prc); Region: prc; TIGR00225 572477010183 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 572477010184 protein binding site [polypeptide binding]; other site 572477010185 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 572477010186 Catalytic dyad [active] 572477010187 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 572477010188 Peptidase family M23; Region: Peptidase_M23; pfam01551 572477010189 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572477010190 dimerization interface [polypeptide binding]; other site 572477010191 putative DNA binding site [nucleotide binding]; other site 572477010192 putative Zn2+ binding site [ion binding]; other site 572477010193 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572477010194 active site residue [active] 572477010195 preprotein translocase subunit SecB; Validated; Region: PRK05751 572477010196 SecA binding site; other site 572477010197 Preprotein binding site; other site 572477010198 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 572477010199 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 572477010200 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 572477010201 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 572477010202 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 572477010203 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572477010204 active site 572477010205 Family description; Region: DsbD_2; pfam13386 572477010206 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 572477010207 active site 572477010208 dimer interface [polypeptide binding]; other site 572477010209 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 572477010210 AAA domain; Region: AAA_31; pfam13614 572477010211 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 572477010212 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 572477010213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477010214 FeS/SAM binding site; other site 572477010215 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 572477010216 methylamine methyltransferase corrinoid protein reductive activase; Region: Rama_corrin_act; TIGR04270 572477010217 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 572477010218 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572477010219 catalytic loop [active] 572477010220 iron binding site [ion binding]; other site 572477010221 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 572477010222 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572477010223 catalytic loop [active] 572477010224 iron binding site [ion binding]; other site 572477010225 NifQ; Region: NifQ; pfam04891 572477010226 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 572477010227 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 572477010228 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 572477010229 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 572477010230 ATP binding site [chemical binding]; other site 572477010231 Mg++ binding site [ion binding]; other site 572477010232 motif III; other site 572477010233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572477010234 nucleotide binding region [chemical binding]; other site 572477010235 ATP-binding site [chemical binding]; other site 572477010236 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 572477010237 putative RNA binding site [nucleotide binding]; other site 572477010238 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 572477010239 Part of AAA domain; Region: AAA_19; pfam13245 572477010240 Family description; Region: UvrD_C_2; pfam13538 572477010241 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 572477010242 RNA binding site [nucleotide binding]; other site 572477010243 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 572477010244 RNA binding site [nucleotide binding]; other site 572477010245 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 572477010246 RNA binding site [nucleotide binding]; other site 572477010247 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 572477010248 RNA binding site [nucleotide binding]; other site 572477010249 domain interface; other site 572477010250 HemN family oxidoreductase; Provisional; Region: PRK05660 572477010251 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477010252 FeS/SAM binding site; other site 572477010253 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 572477010254 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 572477010255 Malic enzyme, N-terminal domain; Region: malic; pfam00390 572477010256 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 572477010257 NAD(P) binding pocket [chemical binding]; other site 572477010258 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 572477010259 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 572477010260 dimer interface [polypeptide binding]; other site 572477010261 active site 572477010262 citrylCoA binding site [chemical binding]; other site 572477010263 NADH binding [chemical binding]; other site 572477010264 cationic pore residues; other site 572477010265 oxalacetate/citrate binding site [chemical binding]; other site 572477010266 coenzyme A binding site [chemical binding]; other site 572477010267 catalytic triad [active] 572477010268 Competence protein A; Region: Competence_A; pfam11104 572477010269 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 572477010270 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 572477010271 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 572477010272 Pilus assembly protein, PilO; Region: PilO; pfam04350 572477010273 Pilus assembly protein, PilP; Region: PilP; pfam04351 572477010274 AMIN domain; Region: AMIN; pfam11741 572477010275 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 572477010276 Secretin and TonB N terminus short domain; Region: STN; smart00965 572477010277 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 572477010278 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 572477010279 shikimate kinase; Reviewed; Region: aroK; PRK00131 572477010280 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 572477010281 ADP binding site [chemical binding]; other site 572477010282 magnesium binding site [ion binding]; other site 572477010283 putative shikimate binding site; other site 572477010284 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 572477010285 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 572477010286 active site 572477010287 dimer interface [polypeptide binding]; other site 572477010288 metal binding site [ion binding]; metal-binding site 572477010289 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572477010290 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 572477010291 putative ADP-binding pocket [chemical binding]; other site 572477010292 O-Antigen ligase; Region: Wzy_C; pfam04932 572477010293 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 572477010294 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572477010295 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 572477010296 putative ADP-binding pocket [chemical binding]; other site 572477010297 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 572477010298 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 572477010299 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 572477010300 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 572477010301 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 572477010302 shikimate binding site; other site 572477010303 NAD(P) binding site [chemical binding]; other site 572477010304 photoactive yellow protein; Region: photo_yellow; TIGR02373 572477010305 PAS fold; Region: PAS; pfam00989 572477010306 PAS fold; Region: PAS_2; pfam08446 572477010307 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 572477010308 GAF domain; Region: GAF; pfam01590 572477010309 Phytochrome region; Region: PHY; pfam00360 572477010310 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477010311 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477010312 metal binding site [ion binding]; metal-binding site 572477010313 active site 572477010314 I-site; other site 572477010315 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477010316 4-coumarate--CoA ligase, photoactive yellow protein activation family; Region: 4_coum_CoA_lig; TIGR02372 572477010317 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572477010318 acyl-activating enzyme (AAE) consensus motif; other site 572477010319 AMP binding site [chemical binding]; other site 572477010320 active site 572477010321 CoA binding site [chemical binding]; other site 572477010322 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 572477010323 dimer interface [polypeptide binding]; other site 572477010324 active site 572477010325 aspartate-rich active site metal binding site; other site 572477010326 allosteric magnesium binding site [ion binding]; other site 572477010327 Schiff base residues; other site 572477010328 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572477010329 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 572477010330 catalytic residues [active] 572477010331 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572477010332 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 572477010333 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 572477010334 putative switch regulator; other site 572477010335 non-specific DNA interactions [nucleotide binding]; other site 572477010336 DNA binding site [nucleotide binding] 572477010337 sequence specific DNA binding site [nucleotide binding]; other site 572477010338 putative cAMP binding site [chemical binding]; other site 572477010339 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 572477010340 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 572477010341 gating phenylalanine in ion channel; other site 572477010342 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 572477010343 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 572477010344 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 572477010345 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 572477010346 MoxR-like ATPases [General function prediction only]; Region: COG0714 572477010347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477010348 ATP binding site [chemical binding]; other site 572477010349 Walker A motif; other site 572477010350 Walker B motif; other site 572477010351 arginine finger; other site 572477010352 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 572477010353 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 572477010354 DNA binding site [nucleotide binding] 572477010355 catalytic residue [active] 572477010356 H2TH interface [polypeptide binding]; other site 572477010357 putative catalytic residues [active] 572477010358 turnover-facilitating residue; other site 572477010359 intercalation triad [nucleotide binding]; other site 572477010360 8OG recognition residue [nucleotide binding]; other site 572477010361 putative reading head residues; other site 572477010362 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 572477010363 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 572477010364 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 572477010365 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 572477010366 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 572477010367 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572477010368 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572477010369 Walker A/P-loop; other site 572477010370 ATP binding site [chemical binding]; other site 572477010371 Q-loop/lid; other site 572477010372 ABC transporter signature motif; other site 572477010373 Walker B; other site 572477010374 D-loop; other site 572477010375 H-loop/switch region; other site 572477010376 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 572477010377 Protein of unknown function DUF58; Region: DUF58; pfam01882 572477010378 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 572477010379 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 572477010380 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 572477010381 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 572477010382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572477010383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572477010384 dimer interface [polypeptide binding]; other site 572477010385 phosphorylation site [posttranslational modification] 572477010386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572477010387 ATP binding site [chemical binding]; other site 572477010388 Mg2+ binding site [ion binding]; other site 572477010389 G-X-G motif; other site 572477010390 Response regulator receiver domain; Region: Response_reg; pfam00072 572477010391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572477010392 active site 572477010393 phosphorylation site [posttranslational modification] 572477010394 intermolecular recognition site; other site 572477010395 dimerization interface [polypeptide binding]; other site 572477010396 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 572477010397 Ligand Binding Site [chemical binding]; other site 572477010398 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 572477010399 active site 572477010400 metal binding site [ion binding]; metal-binding site 572477010401 homotetramer interface [polypeptide binding]; other site 572477010402 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 572477010403 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 572477010404 putative NAD(P) binding site [chemical binding]; other site 572477010405 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 572477010406 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 572477010407 substrate binding site [chemical binding]; other site 572477010408 active site 572477010409 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 572477010410 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 572477010411 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 572477010412 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 572477010413 PemK-like protein; Region: PemK; pfam02452 572477010414 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 572477010415 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 572477010416 putative active site [active] 572477010417 putative NTP binding site [chemical binding]; other site 572477010418 putative nucleic acid binding site [nucleotide binding]; other site 572477010419 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 572477010420 Family description; Region: UvrD_C_2; pfam13538 572477010421 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 572477010422 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 572477010423 AAA domain; Region: AAA_30; pfam13604 572477010424 Family description; Region: UvrD_C_2; pfam13538 572477010425 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 572477010426 CoA binding domain; Region: CoA_binding; cl17356 572477010427 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 572477010428 NAD(P) binding site [chemical binding]; other site 572477010429 homodimer interface [polypeptide binding]; other site 572477010430 substrate binding site [chemical binding]; other site 572477010431 active site 572477010432 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 572477010433 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 572477010434 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572477010435 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 572477010436 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 572477010437 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 572477010438 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 572477010439 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572477010440 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 572477010441 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 572477010442 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 572477010443 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 572477010444 MoaE homodimer interface [polypeptide binding]; other site 572477010445 MoaD interaction [polypeptide binding]; other site 572477010446 active site residues [active] 572477010447 ammonium transporter; Region: amt; TIGR00836 572477010448 PAS domain S-box; Region: sensory_box; TIGR00229 572477010449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572477010450 putative active site [active] 572477010451 heme pocket [chemical binding]; other site 572477010452 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572477010453 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572477010454 metal binding site [ion binding]; metal-binding site 572477010455 active site 572477010456 I-site; other site 572477010457 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572477010458 NnrU protein; Region: NnrU; pfam07298 572477010459 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572477010460 catalytic core [active] 572477010461 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 572477010462 Phosphotransferase enzyme family; Region: APH; pfam01636 572477010463 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572477010464 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 572477010465 active site 572477010466 primosome assembly protein PriA; Validated; Region: PRK05580 572477010467 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572477010468 ATP binding site [chemical binding]; other site 572477010469 putative Mg++ binding site [ion binding]; other site 572477010470 helicase superfamily c-terminal domain; Region: HELICc; smart00490 572477010471 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 572477010472 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 572477010473 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572477010474 active site 572477010475 HIGH motif; other site 572477010476 nucleotide binding site [chemical binding]; other site 572477010477 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 572477010478 KMSK motif region; other site 572477010479 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 572477010480 tRNA binding surface [nucleotide binding]; other site 572477010481 anticodon binding site; other site 572477010482 Sporulation related domain; Region: SPOR; pfam05036 572477010483 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 572477010484 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 572477010485 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 572477010486 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 572477010487 G1 box; other site 572477010488 GTP/Mg2+ binding site [chemical binding]; other site 572477010489 Switch I region; other site 572477010490 G2 box; other site 572477010491 G3 box; other site 572477010492 Switch II region; other site 572477010493 G4 box; other site 572477010494 G5 box; other site 572477010495 Nucleoside recognition; Region: Gate; pfam07670 572477010496 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 572477010497 HDOD domain; Region: HDOD; pfam08668 572477010498 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 572477010499 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 572477010500 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 572477010501 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572477010502 Walker A motif; other site 572477010503 ATP binding site [chemical binding]; other site 572477010504 Walker B motif; other site 572477010505 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 572477010506 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 572477010507 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 572477010508 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 572477010509 trmE is a tRNA modification GTPase; Region: trmE; cd04164 572477010510 G1 box; other site 572477010511 GTP/Mg2+ binding site [chemical binding]; other site 572477010512 Switch I region; other site 572477010513 G2 box; other site 572477010514 Switch II region; other site 572477010515 G3 box; other site 572477010516 G4 box; other site 572477010517 G5 box; other site 572477010518 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 572477010519 membrane protein insertase; Provisional; Region: PRK01318 572477010520 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 572477010521 Haemolytic domain; Region: Haemolytic; pfam01809 572477010522 Ribonuclease P; Region: Ribonuclease_P; cl00457 572477010523 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 572477010524 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 572477010525 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 572477010526 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 572477010527 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 572477010528 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 572477010529 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 572477010530 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 572477010531 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 572477010532 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 572477010533 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477010534 Radical SAM superfamily; Region: Radical_SAM; pfam04055 572477010535 FeS/SAM binding site; other site 572477010536 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572477010537 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 572477010538 FeS/SAM binding site; other site 572477010539 EcsC protein family; Region: EcsC; pfam12787 572477010540 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09741 572477010541 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 572477010542 CRISPR/Cas system-associated protein Csx16; Region: Csx16_III-U; cd09743 572477010543 Short C-terminal domain; Region: SHOCT; pfam09851 572477010544 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 572477010545 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 572477010546 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 572477010547 H-NS histone family; Region: Histone_HNS; pfam00816 572477010548 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 572477010549 Predicted transcriptional regulator [Transcription]; Region: COG2944 572477010550 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572477010551 non-specific DNA binding site [nucleotide binding]; other site 572477010552 salt bridge; other site 572477010553 sequence-specific DNA binding site [nucleotide binding]; other site 572477010554 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 572477010555 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 572477010556 active site 572477010557 substrate binding site [chemical binding]; other site 572477010558 Mg2+ binding site [ion binding]; other site 572477010559 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 572477010560 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 572477010561 TrfA protein; Region: TrfA; pfam07042 572477010562 Replication initiator protein A; Region: RPA; cl17860 572477010563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 572477010564 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572477010565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477010566 S-adenosylmethionine binding site [chemical binding]; other site 572477010567 HNH endonuclease; Region: HNH_4; pfam13395 572477010568 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 572477010569 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572477010570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572477010571 S-adenosylmethionine binding site [chemical binding]; other site 572477010572 YebG protein; Region: YebG; cl01217 572477010573 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 572477010574 hypothetical protein; Reviewed; Region: PRK09588 572477010575 ProQ/FINO family; Region: ProQ; pfam04352 572477010576 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 572477010577 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 572477010578 putative deacylase active site [active] 572477010579 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 572477010580 HNH endonuclease; Region: HNH_2; pfam13391 572477010581 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 572477010582 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 572477010583 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572477010584 ATP binding site [chemical binding]; other site 572477010585 putative Mg++ binding site [ion binding]; other site 572477010586 HsdM N-terminal domain; Region: HsdM_N; pfam12161 572477010587 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 572477010588 Methyltransferase domain; Region: Methyltransf_26; pfam13659 572477010589 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 572477010590 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 572477010591 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 572477010592 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 572477010593 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 572477010594 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572477010595 ATP binding site [chemical binding]; other site 572477010596 putative Mg++ binding site [ion binding]; other site 572477010597 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572477010598 nucleotide binding region [chemical binding]; other site 572477010599 ATP-binding site [chemical binding]; other site 572477010600 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 572477010601 Part of AAA domain; Region: AAA_19; pfam13245 572477010602 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 572477010603 Family description; Region: UvrD_C_2; pfam13538 572477010604 Cupin domain; Region: Cupin_2; pfam07883 572477010605 Predicted periplasmic protein [Function unknown]; Region: COG3904 572477010606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 572477010607 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 572477010608 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 572477010609 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 572477010610 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 572477010611 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572477010612 active site 572477010613 DNA binding site [nucleotide binding] 572477010614 Int/Topo IB signature motif; other site 572477010615 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 572477010616 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572477010617 Magnesium ion binding site [ion binding]; other site 572477010618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572477010619 non-specific DNA binding site [nucleotide binding]; other site 572477010620 salt bridge; other site 572477010621 sequence-specific DNA binding site [nucleotide binding]; other site 572477010622 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572477010623 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572477010624 non-specific DNA binding site [nucleotide binding]; other site 572477010625 salt bridge; other site 572477010626 sequence-specific DNA binding site [nucleotide binding]; other site 572477010627 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 572477010628 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572477010629 Walker A motif; other site 572477010630 ATP binding site [chemical binding]; other site 572477010631 Walker B motif; other site 572477010632 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 572477010633 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 572477010634 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 572477010635 dimer interface [polypeptide binding]; other site 572477010636 ssDNA binding site [nucleotide binding]; other site 572477010637 tetramer (dimer of dimers) interface [polypeptide binding]; other site 572477010638 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572477010639 non-specific DNA binding site [nucleotide binding]; other site 572477010640 salt bridge; other site 572477010641 sequence-specific DNA binding site [nucleotide binding]; other site 572477010642 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 572477010643 AAA ATPase domain; Region: AAA_16; pfam13191 572477010644 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 572477010645 CHAP domain; Region: CHAP; cl17642 572477010646 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 572477010647 Domain of unknown function (DUF1817); Region: DUF1817; cl02292 572477010648 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 572477010649 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 572477010650 putative active site [active] 572477010651 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 572477010652 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572477010653 active site 572477010654 DNA binding site [nucleotide binding] 572477010655 Int/Topo IB signature motif; other site 572477010656 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 572477010657 Protein of unknown function, DUF393; Region: DUF393; pfam04134 572477010658 hypothetical protein; Provisional; Region: PRK01842 572477010659 SEC-C motif; Region: SEC-C; pfam02810 572477010660 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 572477010661 homodimer interaction site [polypeptide binding]; other site 572477010662 cofactor binding site; other site 572477010663 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 572477010664 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 572477010665 oligomer interface [polypeptide binding]; other site 572477010666 metal binding site [ion binding]; metal-binding site 572477010667 metal binding site [ion binding]; metal-binding site 572477010668 Cl binding site [ion binding]; other site 572477010669 aspartate ring; other site 572477010670 basic sphincter; other site 572477010671 putative hydrophobic gate; other site 572477010672 periplasmic entrance; other site 572477010673 Domain of unknown function (DUF1817); Region: DUF1817; cl02292 572477010674 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 572477010675 AAA domain; Region: AAA_30; pfam13604 572477010676 Family description; Region: UvrD_C_2; pfam13538 572477010677 Domain of unknown function DUF302; Region: DUF302; cl01364 572477010678 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572477010679 dimerization interface [polypeptide binding]; other site 572477010680 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572477010681 dimer interface [polypeptide binding]; other site 572477010682 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 572477010683 putative CheW interface [polypeptide binding]; other site 572477010684 SprT-like family; Region: SprT-like; pfam10263 572477010685 SprT homologues; Region: SprT; cl01182 572477010686 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 572477010687 DNA protecting protein DprA; Region: dprA; TIGR00732 572477010688 Initiator Replication protein; Region: Rep_3; pfam01051 572477010689 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 572477010690 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 572477010691 GIY-YIG motif/motif A; other site 572477010692 putative active site [active] 572477010693 putative metal binding site [ion binding]; other site 572477010694 LabA_like proteins; Region: LabA_like; cd06167 572477010695 putative metal binding site [ion binding]; other site 572477010696 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 572477010697 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 572477010698 ParA-like protein; Provisional; Region: PHA02518 572477010699 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572477010700 P-loop; other site 572477010701 Magnesium ion binding site [ion binding]; other site 572477010702 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 572477010703 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 572477010704 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 572477010705 putative active site [active] 572477010706 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 572477010707 HsdM N-terminal domain; Region: HsdM_N; pfam12161 572477010708 Methyltransferase domain; Region: Methyltransf_26; pfam13659 572477010709 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 572477010710 oligomeric interface; other site 572477010711 putative active site [active] 572477010712 homodimer interface [polypeptide binding]; other site 572477010713 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 572477010714 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 572477010715 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 572477010716 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 572477010717 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 572477010718 oligomeric interface; other site 572477010719 putative active site [active] 572477010720 homodimer interface [polypeptide binding]; other site 572477010721 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 572477010722 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 572477010723 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572477010724 ATP binding site [chemical binding]; other site 572477010725 putative Mg++ binding site [ion binding]; other site 572477010726 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 572477010727 IHF dimer interface [polypeptide binding]; other site 572477010728 IHF - DNA interface [nucleotide binding]; other site 572477010729 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 572477010730 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 572477010731 RecT family; Region: RecT; cl04285 572477010732 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 572477010733 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 572477010734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572477010735 Walker A motif; other site 572477010736 ATP binding site [chemical binding]; other site 572477010737 Walker B motif; other site 572477010738 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 572477010739 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 572477010740 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 572477010741 metal ion-dependent adhesion site (MIDAS); other site 572477010742 hypothetical protein; Reviewed; Region: PRK00024 572477010743 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 572477010744 MPN+ (JAMM) motif; other site 572477010745 Zinc-binding site [ion binding]; other site 572477010746 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 572477010747 peptide chain release factor 1; Provisional; Region: PRK04011 572477010748 Flagellin N-methylase; Region: FliB; pfam03692 572477010749 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 572477010750 Predicted transcriptional regulator [Transcription]; Region: COG3905 572477010751 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 572477010752 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 572477010753 catalytic residues [active] 572477010754 catalytic nucleophile [active] 572477010755 Recombinase; Region: Recombinase; pfam07508 572477010756 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 572477010757 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 572477010758 Lipase (class 2); Region: Lipase_2; pfam01674 572477010759 Initiator Replication protein; Region: Rep_3; pfam01051