-- dump date   	20140618_202500
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
715451000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
715451000002	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
715451000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451000004	Walker A motif; other site
715451000005	ATP binding site [chemical binding]; other site
715451000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
715451000007	Walker B motif; other site
715451000008	arginine finger; other site
715451000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
715451000010	DnaA box-binding interface [nucleotide binding]; other site
715451000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
715451000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
715451000013	putative DNA binding surface [nucleotide binding]; other site
715451000014	dimer interface [polypeptide binding]; other site
715451000015	beta-clamp/clamp loader binding surface; other site
715451000016	beta-clamp/translesion DNA polymerase binding surface; other site
715451000017	recombination protein F; Reviewed; Region: recF; PRK00064
715451000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451000019	Walker A/P-loop; other site
715451000020	ATP binding site [chemical binding]; other site
715451000021	Q-loop/lid; other site
715451000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451000023	ABC transporter signature motif; other site
715451000024	Walker B; other site
715451000025	D-loop; other site
715451000026	H-loop/switch region; other site
715451000027	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
715451000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451000029	Mg2+ binding site [ion binding]; other site
715451000030	G-X-G motif; other site
715451000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
715451000032	anchoring element; other site
715451000033	dimer interface [polypeptide binding]; other site
715451000034	ATP binding site [chemical binding]; other site
715451000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
715451000036	active site
715451000037	putative metal-binding site [ion binding]; other site
715451000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
715451000039	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
715451000040	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
715451000041	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
715451000042	dimer interface [polypeptide binding]; other site
715451000043	motif 1; other site
715451000044	active site
715451000045	motif 2; other site
715451000046	motif 3; other site
715451000047	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
715451000048	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
715451000049	Der GTPase activator (YihI); Region: YihI; cl01172
715451000050	Cytochrome c553 [Energy production and conversion]; Region: COG2863
715451000051	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
715451000052	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
715451000053	Cytochrome c; Region: Cytochrom_C; cl11414
715451000054	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
715451000055	G1 box; other site
715451000056	GTP/Mg2+ binding site [chemical binding]; other site
715451000057	Switch I region; other site
715451000058	G2 box; other site
715451000059	G3 box; other site
715451000060	Switch II region; other site
715451000061	G4 box; other site
715451000062	G5 box; other site
715451000063	DNA polymerase I; Provisional; Region: PRK05755
715451000064	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
715451000065	active site
715451000066	metal binding site 1 [ion binding]; metal-binding site
715451000067	putative 5' ssDNA interaction site; other site
715451000068	metal binding site 3; metal-binding site
715451000069	metal binding site 2 [ion binding]; metal-binding site
715451000070	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
715451000071	putative DNA binding site [nucleotide binding]; other site
715451000072	putative metal binding site [ion binding]; other site
715451000073	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
715451000074	active site
715451000075	catalytic site [active]
715451000076	substrate binding site [chemical binding]; other site
715451000077	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
715451000078	active site
715451000079	DNA binding site [nucleotide binding]
715451000080	catalytic site [active]
715451000081	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
715451000082	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
715451000083	conserved cys residue [active]
715451000084	Cation transport protein; Region: TrkH; cl17365
715451000085	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
715451000086	conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731
715451000087	Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818
715451000088	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
715451000089	TrkA-N domain; Region: TrkA_N; pfam02254
715451000090	TrkA-C domain; Region: TrkA_C; pfam02080
715451000091	TrkA-N domain; Region: TrkA_N; pfam02254
715451000092	TrkA-C domain; Region: TrkA_C; pfam02080
715451000093	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
715451000094	16S rRNA methyltransferase B; Provisional; Region: PRK10901
715451000095	putative RNA binding site [nucleotide binding]; other site
715451000096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451000097	S-adenosylmethionine binding site [chemical binding]; other site
715451000098	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
715451000099	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
715451000100	putative active site [active]
715451000101	substrate binding site [chemical binding]; other site
715451000102	putative cosubstrate binding site; other site
715451000103	catalytic site [active]
715451000104	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
715451000105	substrate binding site [chemical binding]; other site
715451000106	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
715451000107	active site
715451000108	catalytic residues [active]
715451000109	metal binding site [ion binding]; metal-binding site
715451000110	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
715451000111	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
715451000112	DNA protecting protein DprA; Region: dprA; TIGR00732
715451000113	Protein of unknown function (DUF494); Region: DUF494; cl01103
715451000114	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
715451000115	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
715451000116	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
715451000117	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
715451000118	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
715451000119	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
715451000120	OmpW family; Region: OmpW; cl17427
715451000121	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
715451000122	apolar tunnel; other site
715451000123	heme binding site [chemical binding]; other site
715451000124	dimerization interface [polypeptide binding]; other site
715451000125	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
715451000126	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
715451000127	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
715451000128	shikimate binding site; other site
715451000129	NAD(P) binding site [chemical binding]; other site
715451000130	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
715451000131	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
715451000132	trimer interface [polypeptide binding]; other site
715451000133	putative metal binding site [ion binding]; other site
715451000134	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451000135	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451000136	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
715451000137	putative effector binding pocket; other site
715451000138	dimerization interface [polypeptide binding]; other site
715451000139	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
715451000140	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
715451000141	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
715451000142	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
715451000143	FAD binding domain; Region: FAD_binding_4; pfam01565
715451000144	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
715451000145	Biotin operon repressor [Transcription]; Region: BirA; COG1654
715451000146	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
715451000147	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
715451000148	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
715451000149	Type III pantothenate kinase; Region: Pan_kinase; cl17198
715451000150	potential protein location (hypothetical protein ambt_00200 [Alteromonas sp. SN2]) that overlaps RNA (tRNA-G)
715451000151	elongation factor Tu; Reviewed; Region: PRK00049
715451000152	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
715451000153	G1 box; other site
715451000154	GEF interaction site [polypeptide binding]; other site
715451000155	GTP/Mg2+ binding site [chemical binding]; other site
715451000156	Switch I region; other site
715451000157	G2 box; other site
715451000158	G3 box; other site
715451000159	Switch II region; other site
715451000160	G4 box; other site
715451000161	G5 box; other site
715451000162	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
715451000163	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
715451000164	Antibiotic Binding Site [chemical binding]; other site
715451000165	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
715451000166	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
715451000167	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
715451000168	heme binding pocket [chemical binding]; other site
715451000169	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
715451000170	Integrase core domain; Region: rve; pfam00665
715451000171	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
715451000172	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451000173	Walker A motif; other site
715451000174	ATP binding site [chemical binding]; other site
715451000175	Walker B motif; other site
715451000176	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
715451000177	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
715451000178	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
715451000179	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
715451000180	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
715451000181	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
715451000182	active site
715451000183	catalytic tetrad [active]
715451000184	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
715451000185	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
715451000186	Porin subfamily; Region: Porin_2; pfam02530
715451000187	acetyl-CoA synthetase; Provisional; Region: PRK00174
715451000188	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
715451000189	active site
715451000190	CoA binding site [chemical binding]; other site
715451000191	acyl-activating enzyme (AAE) consensus motif; other site
715451000192	AMP binding site [chemical binding]; other site
715451000193	acetate binding site [chemical binding]; other site
715451000194	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
715451000195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451000196	active site
715451000197	phosphorylation site [posttranslational modification]
715451000198	intermolecular recognition site; other site
715451000199	dimerization interface [polypeptide binding]; other site
715451000200	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
715451000201	DNA binding residues [nucleotide binding]
715451000202	dimerization interface [polypeptide binding]; other site
715451000203	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
715451000204	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
715451000205	Predicted deacylase [General function prediction only]; Region: COG3608
715451000206	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
715451000207	putative active site [active]
715451000208	Zn binding site [ion binding]; other site
715451000209	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
715451000210	RimK-like ATP-grasp domain; Region: RimK; pfam08443
715451000211	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
715451000212	Mechanosensitive ion channel; Region: MS_channel; pfam00924
715451000213	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
715451000214	Na binding site [ion binding]; other site
715451000215	PAS fold; Region: PAS_7; pfam12860
715451000216	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451000217	dimer interface [polypeptide binding]; other site
715451000218	phosphorylation site [posttranslational modification]
715451000219	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451000220	ATP binding site [chemical binding]; other site
715451000221	Mg2+ binding site [ion binding]; other site
715451000222	G-X-G motif; other site
715451000223	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451000224	active site
715451000225	phosphorylation site [posttranslational modification]
715451000226	intermolecular recognition site; other site
715451000227	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
715451000228	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
715451000229	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
715451000230	Na binding site [ion binding]; other site
715451000231	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
715451000232	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
715451000233	ligand binding site [chemical binding]; other site
715451000234	flexible hinge region; other site
715451000235	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
715451000236	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
715451000237	metal binding triad; other site
715451000238	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
715451000239	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
715451000240	active site
715451000241	catalytic site [active]
715451000242	substrate binding site [chemical binding]; other site
715451000243	Response regulator receiver domain; Region: Response_reg; pfam00072
715451000244	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451000245	active site
715451000246	phosphorylation site [posttranslational modification]
715451000247	intermolecular recognition site; other site
715451000248	dimerization interface [polypeptide binding]; other site
715451000249	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451000250	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451000251	metal binding site [ion binding]; metal-binding site
715451000252	active site
715451000253	I-site; other site
715451000254	MAPEG family; Region: MAPEG; pfam01124
715451000255	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
715451000256	Fasciclin domain; Region: Fasciclin; pfam02469
715451000257	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451000258	TPR repeat; Region: TPR_11; pfam13414
715451000259	binding surface
715451000260	TPR motif; other site
715451000261	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451000262	binding surface
715451000263	TPR motif; other site
715451000264	TPR repeat; Region: TPR_11; pfam13414
715451000265	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
715451000266	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
715451000267	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
715451000268	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
715451000269	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
715451000270	Nucleoside recognition; Region: Gate; pfam07670
715451000271	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
715451000272	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
715451000273	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
715451000274	Sugar specificity; other site
715451000275	Pyrimidine base specificity; other site
715451000276	ATP-binding site [chemical binding]; other site
715451000277	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
715451000278	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
715451000279	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451000280	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
715451000281	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
715451000282	potential catalytic triad [active]
715451000283	conserved cys residue [active]
715451000284	potential frameshift: common BLAST hit: gi|308048890|ref|YP_003912456.1| TonB-dependent receptor
715451000285	potential frameshift: common BLAST hit: gi|157961325|ref|YP_001501359.1| TonB-dependent receptor
715451000286	arginine repressor; Provisional; Region: PRK05066
715451000287	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
715451000288	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
715451000289	malate dehydrogenase; Provisional; Region: PRK05086
715451000290	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
715451000291	NAD binding site [chemical binding]; other site
715451000292	dimerization interface [polypeptide binding]; other site
715451000293	Substrate binding site [chemical binding]; other site
715451000294	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
715451000295	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
715451000296	dimer interface [polypeptide binding]; other site
715451000297	active site
715451000298	heme binding site [chemical binding]; other site
715451000299	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
715451000300	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
715451000301	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
715451000302	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
715451000303	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
715451000304	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
715451000305	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
715451000306	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
715451000307	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
715451000308	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
715451000309	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
715451000310	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
715451000311	E3 interaction surface; other site
715451000312	lipoyl attachment site [posttranslational modification]; other site
715451000313	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
715451000314	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
715451000315	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
715451000316	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
715451000317	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
715451000318	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
715451000319	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
715451000320	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
715451000321	FAD binding pocket [chemical binding]; other site
715451000322	FAD binding motif [chemical binding]; other site
715451000323	phosphate binding motif [ion binding]; other site
715451000324	beta-alpha-beta structure motif; other site
715451000325	NAD binding pocket [chemical binding]; other site
715451000326	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
715451000327	ApbE family; Region: ApbE; pfam02424
715451000328	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991
715451000329	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
715451000330	active site
715451000331	DNA polymerase IV; Validated; Region: PRK02406
715451000332	DNA binding site [nucleotide binding]
715451000333	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
715451000334	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
715451000335	Protein of unknown function (DUF917); Region: DUF917; cl17829
715451000336	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
715451000337	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
715451000338	putative active site [active]
715451000339	putative dimer interface [polypeptide binding]; other site
715451000340	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451000341	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451000342	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
715451000343	dimerization interface [polypeptide binding]; other site
715451000344	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
715451000345	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
715451000346	active site
715451000347	metal binding site [ion binding]; metal-binding site
715451000348	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
715451000349	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
715451000350	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
715451000351	active site
715451000352	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
715451000353	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
715451000354	tetramer interface [polypeptide binding]; other site
715451000355	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451000356	catalytic residue [active]
715451000357	PAS domain S-box; Region: sensory_box; TIGR00229
715451000358	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451000359	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451000360	metal binding site [ion binding]; metal-binding site
715451000361	active site
715451000362	I-site; other site
715451000363	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451000364	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
715451000365	pentamer interface [polypeptide binding]; other site
715451000366	dodecaamer interface [polypeptide binding]; other site
715451000367	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
715451000368	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
715451000369	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
715451000370	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
715451000371	NADH(P)-binding; Region: NAD_binding_10; pfam13460
715451000372	NAD binding site [chemical binding]; other site
715451000373	active site
715451000374	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
715451000375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451000376	S-adenosylmethionine binding site [chemical binding]; other site
715451000377	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
715451000378	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
715451000379	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
715451000380	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
715451000381	DXD motif; other site
715451000382	PilZ domain; Region: PilZ; pfam07238
715451000383	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
715451000384	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
715451000385	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
715451000386	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
715451000387	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
715451000388	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
715451000389	flavodoxin FldB; Provisional; Region: PRK12359
715451000390	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
715451000391	metal binding site [ion binding]; metal-binding site
715451000392	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
715451000393	putative active site [active]
715451000394	putative metal binding site [ion binding]; other site
715451000395	methionine sulfoxide reductase A; Provisional; Region: PRK14054
715451000396	Protein of unknown function, DUF393; Region: DUF393; pfam04134
715451000397	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
715451000398	C factor cell-cell signaling protein; Provisional; Region: PRK09009
715451000399	NAD(P) binding site [chemical binding]; other site
715451000400	active site
715451000401	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
715451000402	Na2 binding site [ion binding]; other site
715451000403	putative substrate binding site 1 [chemical binding]; other site
715451000404	Na binding site 1 [ion binding]; other site
715451000405	putative substrate binding site 2 [chemical binding]; other site
715451000406	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
715451000407	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
715451000408	putative NAD(P) binding site [chemical binding]; other site
715451000409	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
715451000410	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
715451000411	Mechanosensitive ion channel; Region: MS_channel; pfam00924
715451000412	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
715451000413	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
715451000414	putative acyl-acceptor binding pocket; other site
715451000415	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
715451000416	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
715451000417	putative acyl-acceptor binding pocket; other site
715451000418	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
715451000419	S-formylglutathione hydrolase; Region: PLN02442
715451000420	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451000421	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451000422	metal binding site [ion binding]; metal-binding site
715451000423	active site
715451000424	I-site; other site
715451000425	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451000426	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
715451000427	Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154
715451000428	Rab subfamily motif 1 (RabSF1); other site
715451000429	G1 box; other site
715451000430	GTP/Mg2+ binding site [chemical binding]; other site
715451000431	Rab subfamily motif 2 (RabSF2); other site
715451000432	Switch I region; other site
715451000433	G2 box; other site
715451000434	effector interaction site; other site
715451000435	GDI interaction site; other site
715451000436	Rab family motif 1 (RabF1); other site
715451000437	GEF interaction site [polypeptide binding]; other site
715451000438	Rab family motif 2 (RabF2); other site
715451000439	G3 box; other site
715451000440	Switch II region; other site
715451000441	Rab family motif 3 (RabF3); other site
715451000442	Rab family motif 4 (RabF4); other site
715451000443	Rab family motif 5 (RabF5); other site
715451000444	Rab subfamily motif 3 (RabSF3); other site
715451000445	G4 box; other site
715451000446	G5 box; other site
715451000447	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
715451000448	ligand binding site [chemical binding]; other site
715451000449	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
715451000450	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
715451000451	FMN binding site [chemical binding]; other site
715451000452	active site
715451000453	catalytic residues [active]
715451000454	substrate binding site [chemical binding]; other site
715451000455	phage shock protein A; Region: phageshock_pspA; TIGR02977
715451000456	PspC domain; Region: PspC; pfam04024
715451000457	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095
715451000458	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
715451000459	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
715451000460	Flavodoxin; Region: Flavodoxin_1; pfam00258
715451000461	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
715451000462	FAD binding pocket [chemical binding]; other site
715451000463	FAD binding motif [chemical binding]; other site
715451000464	catalytic residues [active]
715451000465	NAD binding pocket [chemical binding]; other site
715451000466	phosphate binding motif [ion binding]; other site
715451000467	beta-alpha-beta structure motif; other site
715451000468	sulfite reductase subunit beta; Provisional; Region: PRK13504
715451000469	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
715451000470	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
715451000471	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
715451000472	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
715451000473	Active Sites [active]
715451000474	TIGR03899 family protein; Region: TIGR03899
715451000475	Response regulator receiver domain; Region: Response_reg; pfam00072
715451000476	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451000477	active site
715451000478	phosphorylation site [posttranslational modification]
715451000479	intermolecular recognition site; other site
715451000480	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
715451000481	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451000482	metal binding site [ion binding]; metal-binding site
715451000483	active site
715451000484	I-site; other site
715451000485	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451000486	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
715451000487	ligand binding site [chemical binding]; other site
715451000488	active site
715451000489	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
715451000490	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
715451000491	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
715451000492	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
715451000493	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
715451000494	Fatty acid desaturase; Region: FA_desaturase; pfam00487
715451000495	Di-iron ligands [ion binding]; other site
715451000496	potential frameshift: common BLAST hit: gi|109897437|ref|YP_660692.1| DSBA oxidoreductase
715451000497	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
715451000498	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451000499	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
715451000500	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451000501	S-adenosylmethionine binding site [chemical binding]; other site
715451000502	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
715451000503	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
715451000504	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
715451000505	EF-hand domain pair; Region: EF_hand_5; pfam13499
715451000506	Ca2+ binding site [ion binding]; other site
715451000507	DNA polymerase II; Reviewed; Region: PRK05762
715451000508	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
715451000509	active site
715451000510	catalytic site [active]
715451000511	substrate binding site [chemical binding]; other site
715451000512	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
715451000513	active site
715451000514	metal-binding site
715451000515	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
715451000516	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
715451000517	dimer interface [polypeptide binding]; other site
715451000518	phosphorylation site [posttranslational modification]
715451000519	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451000520	ATP binding site [chemical binding]; other site
715451000521	Mg2+ binding site [ion binding]; other site
715451000522	G-X-G motif; other site
715451000523	CheC-like family; Region: CheC; pfam04509
715451000524	Chemotaxis phosphatase CheX; Region: CheX; cl15816
715451000525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451000526	Response regulator receiver domain; Region: Response_reg; pfam00072
715451000527	active site
715451000528	phosphorylation site [posttranslational modification]
715451000529	intermolecular recognition site; other site
715451000530	dimerization interface [polypeptide binding]; other site
715451000531	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
715451000532	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
715451000533	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451000534	homodimer interface [polypeptide binding]; other site
715451000535	catalytic residue [active]
715451000536	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
715451000537	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451000538	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451000539	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451000540	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451000541	LysR substrate binding domain; Region: LysR_substrate; pfam03466
715451000542	dimerization interface [polypeptide binding]; other site
715451000543	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
715451000544	putative catalytic site [active]
715451000545	putative metal binding site [ion binding]; other site
715451000546	putative phosphate binding site [ion binding]; other site
715451000547	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
715451000548	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
715451000549	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
715451000550	putative active site [active]
715451000551	putative active site [active]
715451000552	catalytic site [active]
715451000553	catalytic site [active]
715451000554	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
715451000555	putative active site [active]
715451000556	catalytic site [active]
715451000557	Uncharacterized conserved protein [Function unknown]; Region: COG0398
715451000558	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
715451000559	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451000560	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451000561	metal binding site [ion binding]; metal-binding site
715451000562	active site
715451000563	I-site; other site
715451000564	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
715451000565	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
715451000566	TrkA-N domain; Region: TrkA_N; pfam02254
715451000567	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
715451000568	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
715451000569	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
715451000570	heme binding site [chemical binding]; other site
715451000571	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
715451000572	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
715451000573	Mechanosensitive ion channel; Region: MS_channel; pfam00924
715451000574	Transcriptional regulators [Transcription]; Region: FadR; COG2186
715451000575	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
715451000576	DNA-binding site [nucleotide binding]; DNA binding site
715451000577	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
715451000578	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
715451000579	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
715451000580	substrate binding site [chemical binding]; other site
715451000581	ATP binding site [chemical binding]; other site
715451000582	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
715451000583	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
715451000584	active site
715451000585	intersubunit interface [polypeptide binding]; other site
715451000586	catalytic residue [active]
715451000587	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
715451000588	dimerization interface [polypeptide binding]; other site
715451000589	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451000590	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451000591	metal binding site [ion binding]; metal-binding site
715451000592	active site
715451000593	I-site; other site
715451000594	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451000595	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
715451000596	ATP binding site [chemical binding]; other site
715451000597	Mg++ binding site [ion binding]; other site
715451000598	motif III; other site
715451000599	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451000600	nucleotide binding region [chemical binding]; other site
715451000601	ATP-binding site [chemical binding]; other site
715451000602	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
715451000603	phosphopeptide binding site; other site
715451000604	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
715451000605	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
715451000606	phosphopeptide binding site; other site
715451000607	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
715451000608	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
715451000609	Walker A/P-loop; other site
715451000610	ATP binding site [chemical binding]; other site
715451000611	Q-loop/lid; other site
715451000612	ABC transporter signature motif; other site
715451000613	Walker B; other site
715451000614	D-loop; other site
715451000615	H-loop/switch region; other site
715451000616	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
715451000617	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
715451000618	active site
715451000619	Zn binding site [ion binding]; other site
715451000620	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
715451000621	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
715451000622	phosphopeptide binding site; other site
715451000623	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
715451000624	active site
715451000625	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
715451000626	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
715451000627	Catalytic domain of Protein Kinases; Region: PKc; cd00180
715451000628	active site
715451000629	ATP binding site [chemical binding]; other site
715451000630	substrate binding site [chemical binding]; other site
715451000631	activation loop (A-loop); other site
715451000632	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
715451000633	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
715451000634	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
715451000635	phosphopeptide binding site; other site
715451000636	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
715451000637	phosphopeptide binding site; other site
715451000638	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
715451000639	active site
715451000640	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
715451000641	Domain of unknown function (DUF4078); Region: DUF4078; pfam13300
715451000642	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
715451000643	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
715451000644	phosphopeptide binding site; other site
715451000645	von Willebrand factor type A domain; Region: VWA_2; pfam13519
715451000646	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
715451000647	metal ion-dependent adhesion site (MIDAS); other site
715451000648	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
715451000649	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
715451000650	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
715451000651	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
715451000652	Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075
715451000653	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451000654	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451000655	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
715451000656	putative effector binding pocket; other site
715451000657	dimerization interface [polypeptide binding]; other site
715451000658	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
715451000659	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
715451000660	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451000661	Domain of unknown function (DUF1993); Region: DUF1993; cl01567
715451000662	Transposase; Region: HTH_Tnp_1; pfam01527
715451000663	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
715451000664	HTH-like domain; Region: HTH_21; pfam13276
715451000665	Integrase core domain; Region: rve; pfam00665
715451000666	Integrase core domain; Region: rve_3; pfam13683
715451000667	Transcriptional regulators [Transcription]; Region: FadR; COG2186
715451000668	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
715451000669	DNA-binding site [nucleotide binding]; DNA binding site
715451000670	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
715451000671	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
715451000672	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
715451000673	Histidine kinase; Region: HisKA_3; pfam07730
715451000674	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451000675	ATP binding site [chemical binding]; other site
715451000676	Mg2+ binding site [ion binding]; other site
715451000677	G-X-G motif; other site
715451000678	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
715451000679	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451000680	active site
715451000681	phosphorylation site [posttranslational modification]
715451000682	intermolecular recognition site; other site
715451000683	dimerization interface [polypeptide binding]; other site
715451000684	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
715451000685	DNA binding residues [nucleotide binding]
715451000686	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
715451000687	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
715451000688	NAD(P) binding site [chemical binding]; other site
715451000689	catalytic residues [active]
715451000690	FMN-binding domain; Region: FMN_bind; cl01081
715451000691	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
715451000692	4Fe-4S binding domain; Region: Fer4_5; pfam12801
715451000693	Uncharacterized conserved protein [Function unknown]; Region: COG3287
715451000694	FIST N domain; Region: FIST; pfam08495
715451000695	FIST C domain; Region: FIST_C; pfam10442
715451000696	PAS fold; Region: PAS_7; pfam12860
715451000697	PAS fold; Region: PAS_4; pfam08448
715451000698	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451000699	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451000700	dimer interface [polypeptide binding]; other site
715451000701	phosphorylation site [posttranslational modification]
715451000702	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451000703	ATP binding site [chemical binding]; other site
715451000704	G-X-G motif; other site
715451000705	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451000706	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451000707	active site
715451000708	phosphorylation site [posttranslational modification]
715451000709	intermolecular recognition site; other site
715451000710	dimerization interface [polypeptide binding]; other site
715451000711	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
715451000712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451000713	active site
715451000714	phosphorylation site [posttranslational modification]
715451000715	intermolecular recognition site; other site
715451000716	dimerization interface [polypeptide binding]; other site
715451000717	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
715451000718	DNA binding residues [nucleotide binding]
715451000719	dimerization interface [polypeptide binding]; other site
715451000720	Short C-terminal domain; Region: SHOCT; pfam09851
715451000721	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451000722	potential frameshift: common BLAST hit: gi|71279795|ref|YP_268656.1| TonB-dependent receptor
715451000723	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
715451000724	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
715451000725	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
715451000726	FeS/SAM binding site; other site
715451000727	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
715451000728	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
715451000729	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
715451000730	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
715451000731	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
715451000732	multifunctional aminopeptidase A; Provisional; Region: PRK00913
715451000733	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
715451000734	interface (dimer of trimers) [polypeptide binding]; other site
715451000735	Substrate-binding/catalytic site; other site
715451000736	Zn-binding sites [ion binding]; other site
715451000737	ABC-2 type transporter; Region: ABC2_membrane; cl17235
715451000738	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
715451000739	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
715451000740	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451000741	Walker A/P-loop; other site
715451000742	ATP binding site [chemical binding]; other site
715451000743	Q-loop/lid; other site
715451000744	ABC transporter signature motif; other site
715451000745	Walker B; other site
715451000746	D-loop; other site
715451000747	H-loop/switch region; other site
715451000748	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
715451000749	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
715451000750	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
715451000751	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
715451000752	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
715451000753	ligand binding site [chemical binding]; other site
715451000754	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
715451000755	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
715451000756	substrate binding pocket [chemical binding]; other site
715451000757	membrane-bound complex binding site; other site
715451000758	hinge residues; other site
715451000759	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
715451000760	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
715451000761	dimer interface [polypeptide binding]; other site
715451000762	Trp docking motif [polypeptide binding]; other site
715451000763	active site
715451000764	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
715451000765	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451000766	Tetratricopeptide repeat; Region: TPR_12; pfam13424
715451000767	TPR motif; other site
715451000768	binding surface
715451000769	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451000770	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451000771	metal binding site [ion binding]; metal-binding site
715451000772	active site
715451000773	I-site; other site
715451000774	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
715451000775	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
715451000776	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451000777	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451000778	metal binding site [ion binding]; metal-binding site
715451000779	active site
715451000780	I-site; other site
715451000781	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
715451000782	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
715451000783	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
715451000784	dimer interface [polypeptide binding]; other site
715451000785	conserved gate region; other site
715451000786	putative PBP binding loops; other site
715451000787	ABC-ATPase subunit interface; other site
715451000788	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
715451000789	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
715451000790	dimer interface [polypeptide binding]; other site
715451000791	conserved gate region; other site
715451000792	putative PBP binding loops; other site
715451000793	ABC-ATPase subunit interface; other site
715451000794	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
715451000795	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
715451000796	Walker A/P-loop; other site
715451000797	ATP binding site [chemical binding]; other site
715451000798	Q-loop/lid; other site
715451000799	ABC transporter signature motif; other site
715451000800	Walker B; other site
715451000801	D-loop; other site
715451000802	H-loop/switch region; other site
715451000803	TOBE domain; Region: TOBE_2; pfam08402
715451000804	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
715451000805	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
715451000806	motif II; other site
715451000807	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
715451000808	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
715451000809	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
715451000810	active site
715451000811	CHAT domain; Region: CHAT; pfam12770
715451000812	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
715451000813	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451000814	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
715451000815	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
715451000816	homotrimer interaction site [polypeptide binding]; other site
715451000817	putative active site [active]
715451000818	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
715451000819	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
715451000820	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
715451000821	NAD binding site [chemical binding]; other site
715451000822	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451000823	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451000824	metal binding site [ion binding]; metal-binding site
715451000825	active site
715451000826	I-site; other site
715451000827	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
715451000828	Asp-box motif; other site
715451000829	catalytic site [active]
715451000830	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
715451000831	active site flap/lid [active]
715451000832	nucleophilic elbow; other site
715451000833	catalytic triad [active]
715451000834	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
715451000835	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
715451000836	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
715451000837	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451000838	binding surface
715451000839	TPR motif; other site
715451000840	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
715451000841	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
715451000842	potential protein location (hypothetical protein ambt_01360 [Alteromonas sp. SN2]) that overlaps RNA (tRNA-L)
715451000843	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
715451000844	Domain of unknown function (DUF4331); Region: DUF4331; pfam14224
715451000845	putative anti-sigmaE protein; Provisional; Region: PRK13920
715451000846	Anti-sigma-K factor rskA; Region: RskA; pfam10099
715451000847	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
715451000848	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451000849	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
715451000850	DNA binding residues [nucleotide binding]
715451000851	RDD family; Region: RDD; pfam06271
715451000852	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
715451000853	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
715451000854	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
715451000855	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
715451000856	multifunctional aminopeptidase A; Provisional; Region: PRK00913
715451000857	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
715451000858	interface (dimer of trimers) [polypeptide binding]; other site
715451000859	Substrate-binding/catalytic site; other site
715451000860	Zn-binding sites [ion binding]; other site
715451000861	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
715451000862	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
715451000863	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
715451000864	HIGH motif; other site
715451000865	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
715451000866	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
715451000867	active site
715451000868	KMSKS motif; other site
715451000869	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
715451000870	tRNA binding surface [nucleotide binding]; other site
715451000871	anticodon binding site; other site
715451000872	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
715451000873	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
715451000874	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451000875	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451000876	dimer interface [polypeptide binding]; other site
715451000877	phosphorylation site [posttranslational modification]
715451000878	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451000879	ATP binding site [chemical binding]; other site
715451000880	Mg2+ binding site [ion binding]; other site
715451000881	G-X-G motif; other site
715451000882	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451000883	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451000884	active site
715451000885	phosphorylation site [posttranslational modification]
715451000886	intermolecular recognition site; other site
715451000887	dimerization interface [polypeptide binding]; other site
715451000888	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
715451000889	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
715451000890	PAS domain; Region: PAS; smart00091
715451000891	PAS fold; Region: PAS_4; pfam08448
715451000892	PAS domain; Region: PAS_9; pfam13426
715451000893	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451000894	putative active site [active]
715451000895	heme pocket [chemical binding]; other site
715451000896	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451000897	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451000898	metal binding site [ion binding]; metal-binding site
715451000899	active site
715451000900	I-site; other site
715451000901	RNase E inhibitor protein; Provisional; Region: PRK11191
715451000902	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
715451000903	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
715451000904	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
715451000905	putative acyl-acceptor binding pocket; other site
715451000906	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
715451000907	putative binding surface; other site
715451000908	active site
715451000909	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
715451000910	Zn2+ binding site [ion binding]; other site
715451000911	Mg2+ binding site [ion binding]; other site
715451000912	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
715451000913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451000914	active site
715451000915	phosphorylation site [posttranslational modification]
715451000916	intermolecular recognition site; other site
715451000917	dimerization interface [polypeptide binding]; other site
715451000918	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451000919	Walker A motif; other site
715451000920	ATP binding site [chemical binding]; other site
715451000921	Walker B motif; other site
715451000922	arginine finger; other site
715451000923	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
715451000924	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
715451000925	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451000926	putative active site [active]
715451000927	heme pocket [chemical binding]; other site
715451000928	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451000929	dimer interface [polypeptide binding]; other site
715451000930	phosphorylation site [posttranslational modification]
715451000931	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451000932	ATP binding site [chemical binding]; other site
715451000933	Mg2+ binding site [ion binding]; other site
715451000934	G-X-G motif; other site
715451000935	Membrane GTPase LepA [Cell envelope biogenesis, outer membrane]; Region: LepA; COG0481
715451000936	glutamine synthetase; Provisional; Region: glnA; PRK09469
715451000937	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
715451000938	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
715451000939	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
715451000940	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
715451000941	G1 box; other site
715451000942	putative GEF interaction site [polypeptide binding]; other site
715451000943	GTP/Mg2+ binding site [chemical binding]; other site
715451000944	Switch I region; other site
715451000945	G2 box; other site
715451000946	G3 box; other site
715451000947	Switch II region; other site
715451000948	G4 box; other site
715451000949	G5 box; other site
715451000950	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
715451000951	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
715451000952	Response regulator receiver domain; Region: Response_reg; pfam00072
715451000953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451000954	active site
715451000955	phosphorylation site [posttranslational modification]
715451000956	intermolecular recognition site; other site
715451000957	dimerization interface [polypeptide binding]; other site
715451000958	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
715451000959	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
715451000960	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451000961	homodimer interface [polypeptide binding]; other site
715451000962	catalytic residue [active]
715451000963	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
715451000964	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
715451000965	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
715451000966	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
715451000967	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
715451000968	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
715451000969	Cl- selectivity filter; other site
715451000970	Cl- binding residues [ion binding]; other site
715451000971	pore gating glutamate residue; other site
715451000972	dimer interface [polypeptide binding]; other site
715451000973	Protein of unknown function (DUF2899); Region: DUF2899; pfam11449
715451000974	Protein of unknown function (DUF2899); Region: DUF2899; pfam11449
715451000975	fumarate hydratase; Reviewed; Region: fumC; PRK00485
715451000976	Class II fumarases; Region: Fumarase_classII; cd01362
715451000977	active site
715451000978	tetramer interface [polypeptide binding]; other site
715451000979	septum formation inhibitor; Reviewed; Region: minC; PRK00339
715451000980	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
715451000981	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
715451000982	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
715451000983	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
715451000984	Switch I; other site
715451000985	Switch II; other site
715451000986	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
715451000987	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
715451000988	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
715451000989	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
715451000990	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
715451000991	C-terminal domain interface [polypeptide binding]; other site
715451000992	GSH binding site (G-site) [chemical binding]; other site
715451000993	dimer interface [polypeptide binding]; other site
715451000994	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
715451000995	N-terminal domain interface [polypeptide binding]; other site
715451000996	dimer interface [polypeptide binding]; other site
715451000997	substrate binding pocket (H-site) [chemical binding]; other site
715451000998	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
715451000999	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
715451001000	NAD binding site [chemical binding]; other site
715451001001	ligand binding site [chemical binding]; other site
715451001002	catalytic site [active]
715451001003	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
715451001004	putative hydrophobic ligand binding site [chemical binding]; other site
715451001005	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
715451001006	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
715451001007	FMN binding site [chemical binding]; other site
715451001008	active site
715451001009	substrate binding site [chemical binding]; other site
715451001010	catalytic residue [active]
715451001011	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
715451001012	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
715451001013	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451001014	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
715451001015	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
715451001016	substrate binding pocket [chemical binding]; other site
715451001017	membrane-bound complex binding site; other site
715451001018	hinge residues; other site
715451001019	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
715451001020	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
715451001021	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
715451001022	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
715451001023	putative peptidase; Provisional; Region: PRK11649
715451001024	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
715451001025	Peptidase family M23; Region: Peptidase_M23; pfam01551
715451001026	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
715451001027	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
715451001028	active site
715451001029	HIGH motif; other site
715451001030	dimer interface [polypeptide binding]; other site
715451001031	KMSKS motif; other site
715451001032	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
715451001033	RNA binding surface [nucleotide binding]; other site
715451001034	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
715451001035	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
715451001036	active site residue [active]
715451001037	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
715451001038	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
715451001039	cobalamin binding residues [chemical binding]; other site
715451001040	putative BtuC binding residues; other site
715451001041	dimer interface [polypeptide binding]; other site
715451001042	CobD/Cbib protein; Region: CobD_Cbib; cl00561
715451001043	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
715451001044	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
715451001045	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
715451001046	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
715451001047	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
715451001048	non-specific DNA binding site [nucleotide binding]; other site
715451001049	salt bridge; other site
715451001050	sequence-specific DNA binding site [nucleotide binding]; other site
715451001051	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
715451001052	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
715451001053	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
715451001054	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
715451001055	active site
715451001056	dimer interface [polypeptide binding]; other site
715451001057	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
715451001058	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
715451001059	active site
715451001060	FMN binding site [chemical binding]; other site
715451001061	substrate binding site [chemical binding]; other site
715451001062	3Fe-4S cluster binding site [ion binding]; other site
715451001063	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
715451001064	domain interface; other site
715451001065	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
715451001066	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451001067	putative active site [active]
715451001068	heme pocket [chemical binding]; other site
715451001069	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451001070	dimer interface [polypeptide binding]; other site
715451001071	phosphorylation site [posttranslational modification]
715451001072	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451001073	ATP binding site [chemical binding]; other site
715451001074	Mg2+ binding site [ion binding]; other site
715451001075	G-X-G motif; other site
715451001076	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451001077	active site
715451001078	phosphorylation site [posttranslational modification]
715451001079	intermolecular recognition site; other site
715451001080	dimerization interface [polypeptide binding]; other site
715451001081	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
715451001082	putative binding surface; other site
715451001083	active site
715451001084	Bacterial PH domain; Region: DUF304; cl01348
715451001085	Bacterial PH domain; Region: DUF304; pfam03703
715451001086	Bacterial PH domain; Region: DUF304; cl01348
715451001087	Bacterial PH domain; Region: DUF304; cl01348
715451001088	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451001089	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451001090	active site
715451001091	phosphorylation site [posttranslational modification]
715451001092	intermolecular recognition site; other site
715451001093	dimerization interface [polypeptide binding]; other site
715451001094	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451001095	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451001096	active site
715451001097	phosphorylation site [posttranslational modification]
715451001098	intermolecular recognition site; other site
715451001099	dimerization interface [polypeptide binding]; other site
715451001100	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451001101	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451001102	metal binding site [ion binding]; metal-binding site
715451001103	active site
715451001104	I-site; other site
715451001105	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
715451001106	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
715451001107	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
715451001108	substrate binding site [chemical binding]; other site
715451001109	ligand binding site [chemical binding]; other site
715451001110	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
715451001111	substrate binding site [chemical binding]; other site
715451001112	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
715451001113	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
715451001114	dimer interface [polypeptide binding]; other site
715451001115	active site
715451001116	citrylCoA binding site [chemical binding]; other site
715451001117	oxalacetate/citrate binding site [chemical binding]; other site
715451001118	coenzyme A binding site [chemical binding]; other site
715451001119	catalytic triad [active]
715451001120	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
715451001121	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
715451001122	tetramer interface [polypeptide binding]; other site
715451001123	active site
715451001124	Mg2+/Mn2+ binding site [ion binding]; other site
715451001125	Transcriptional regulators [Transcription]; Region: GntR; COG1802
715451001126	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
715451001127	DNA-binding site [nucleotide binding]; DNA binding site
715451001128	FCD domain; Region: FCD; pfam07729
715451001129	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
715451001130	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451001131	N-terminal plug; other site
715451001132	ligand-binding site [chemical binding]; other site
715451001133	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
715451001134	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451001135	active site
715451001136	phosphorylation site [posttranslational modification]
715451001137	intermolecular recognition site; other site
715451001138	dimerization interface [polypeptide binding]; other site
715451001139	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
715451001140	dimerization interface [polypeptide binding]; other site
715451001141	DNA binding residues [nucleotide binding]
715451001142	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
715451001143	Histidine kinase; Region: HisKA_3; pfam07730
715451001144	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
715451001145	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
715451001146	Domain of unknown function (DUF4355); Region: DUF4355; pfam14265
715451001147	putative transporter; Provisional; Region: PRK10504
715451001148	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451001149	putative substrate translocation pore; other site
715451001150	outer membrane lipoprotein; Provisional; Region: PRK11023
715451001151	BON domain; Region: BON; pfam04972
715451001152	BON domain; Region: BON; pfam04972
715451001153	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
715451001154	dimer interface [polypeptide binding]; other site
715451001155	active site
715451001156	hypothetical protein; Reviewed; Region: PRK12497
715451001157	LppC putative lipoprotein; Region: LppC; pfam04348
715451001158	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
715451001159	putative ligand binding site [chemical binding]; other site
715451001160	Predicted methyltransferases [General function prediction only]; Region: COG0313
715451001161	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
715451001162	putative SAM binding site [chemical binding]; other site
715451001163	putative homodimer interface [polypeptide binding]; other site
715451001164	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
715451001165	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
715451001166	dimer interface [polypeptide binding]; other site
715451001167	active site
715451001168	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
715451001169	catalytic residues [active]
715451001170	substrate binding site [chemical binding]; other site
715451001171	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
715451001172	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
715451001173	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
715451001174	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
715451001175	catalytic residue [active]
715451001176	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
715451001177	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451001178	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
715451001179	dimerization interface [polypeptide binding]; other site
715451001180	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451001181	dimer interface [polypeptide binding]; other site
715451001182	phosphorylation site [posttranslational modification]
715451001183	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451001184	ATP binding site [chemical binding]; other site
715451001185	Mg2+ binding site [ion binding]; other site
715451001186	G-X-G motif; other site
715451001187	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
715451001188	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451001189	active site
715451001190	phosphorylation site [posttranslational modification]
715451001191	intermolecular recognition site; other site
715451001192	dimerization interface [polypeptide binding]; other site
715451001193	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451001194	DNA binding site [nucleotide binding]
715451001195	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
715451001196	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
715451001197	Response regulator receiver domain; Region: Response_reg; pfam00072
715451001198	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451001199	active site
715451001200	phosphorylation site [posttranslational modification]
715451001201	intermolecular recognition site; other site
715451001202	dimerization interface [polypeptide binding]; other site
715451001203	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
715451001204	arsenical-resistance protein; Region: acr3; TIGR00832
715451001205	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
715451001206	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
715451001207	Low molecular weight phosphatase family; Region: LMWPc; cl00105
715451001208	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
715451001209	active site
715451001210	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
715451001211	dimerization interface [polypeptide binding]; other site
715451001212	putative DNA binding site [nucleotide binding]; other site
715451001213	putative Zn2+ binding site [ion binding]; other site
715451001214	Putative phosphatase (DUF442); Region: DUF442; cl17385
715451001215	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
715451001216	Histidine kinase; Region: HisKA_3; pfam07730
715451001217	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
715451001218	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
715451001219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451001220	active site
715451001221	phosphorylation site [posttranslational modification]
715451001222	intermolecular recognition site; other site
715451001223	dimerization interface [polypeptide binding]; other site
715451001224	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
715451001225	DNA binding residues [nucleotide binding]
715451001226	dimerization interface [polypeptide binding]; other site
715451001227	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
715451001228	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
715451001229	substrate binding site [chemical binding]; other site
715451001230	catalytic Zn binding site [ion binding]; other site
715451001231	NAD binding site [chemical binding]; other site
715451001232	structural Zn binding site [ion binding]; other site
715451001233	dimer interface [polypeptide binding]; other site
715451001234	LysR family transcriptional regulator; Provisional; Region: PRK14997
715451001235	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451001236	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
715451001237	dimerization interface [polypeptide binding]; other site
715451001238	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
715451001239	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
715451001240	putative catalytic residues [active]
715451001241	putative nucleotide binding site [chemical binding]; other site
715451001242	putative aspartate binding site [chemical binding]; other site
715451001243	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
715451001244	dimer interface [polypeptide binding]; other site
715451001245	putative threonine allosteric regulatory site; other site
715451001246	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
715451001247	putative threonine allosteric regulatory site; other site
715451001248	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
715451001249	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
715451001250	homoserine kinase; Provisional; Region: PRK01212
715451001251	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
715451001252	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
715451001253	threonine synthase; Validated; Region: PRK09225
715451001254	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
715451001255	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
715451001256	catalytic residue [active]
715451001257	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
715451001258	ligand binding site [chemical binding]; other site
715451001259	active site
715451001260	UGI interface [polypeptide binding]; other site
715451001261	catalytic site [active]
715451001262	Protein of unknown function (DUF3545); Region: DUF3545; pfam12065
715451001263	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
715451001264	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
715451001265	active site
715451001266	dimer interface [polypeptide binding]; other site
715451001267	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
715451001268	dimer interface [polypeptide binding]; other site
715451001269	active site
715451001270	transaldolase-like protein; Provisional; Region: PTZ00411
715451001271	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
715451001272	active site
715451001273	dimer interface [polypeptide binding]; other site
715451001274	catalytic residue [active]
715451001275	hypothetical protein; Validated; Region: PRK02101
715451001276	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
715451001277	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
715451001278	putative C-terminal domain interface [polypeptide binding]; other site
715451001279	putative GSH binding site (G-site) [chemical binding]; other site
715451001280	putative dimer interface [polypeptide binding]; other site
715451001281	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
715451001282	N-terminal domain interface [polypeptide binding]; other site
715451001283	dimer interface [polypeptide binding]; other site
715451001284	substrate binding pocket (H-site) [chemical binding]; other site
715451001285	The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320
715451001286	putative tRNA-binding site [nucleotide binding]; other site
715451001287	Alginate lyase; Region: Alginate_lyase2; pfam08787
715451001288	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
715451001289	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
715451001290	active site
715451001291	metal binding site [ion binding]; metal-binding site
715451001292	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
715451001293	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
715451001294	active site
715451001295	FMN binding site [chemical binding]; other site
715451001296	2,4-decadienoyl-CoA binding site; other site
715451001297	catalytic residue [active]
715451001298	4Fe-4S cluster binding site [ion binding]; other site
715451001299	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
715451001300	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
715451001301	Domain of unknown function (DUF4426); Region: DUF4426; pfam14467
715451001302	YGGT family; Region: YGGT; pfam02325
715451001303	YGGT family; Region: YGGT; pfam02325
715451001304	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
715451001305	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
715451001306	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
715451001307	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
715451001308	catalytic residue [active]
715451001309	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
715451001310	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
715451001311	Walker A motif; other site
715451001312	ATP binding site [chemical binding]; other site
715451001313	Walker B motif; other site
715451001314	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
715451001315	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
715451001316	ATP binding site [chemical binding]; other site
715451001317	Walker B motif; other site
715451001318	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
715451001319	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
715451001320	hypothetical protein; Validated; Region: PRK00228
715451001321	glutathione synthetase; Provisional; Region: PRK05246
715451001322	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
715451001323	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
715451001324	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
715451001325	RNA methyltransferase, RsmE family; Region: TIGR00046
715451001326	Mechanosensitive ion channel; Region: MS_channel; pfam00924
715451001327	Peptidase family M48; Region: Peptidase_M48; pfam01435
715451001328	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
715451001329	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
715451001330	dimer interface [polypeptide binding]; other site
715451001331	active site
715451001332	CoA binding pocket [chemical binding]; other site
715451001333	putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916
715451001334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451001335	ATP binding site [chemical binding]; other site
715451001336	Mg2+ binding site [ion binding]; other site
715451001337	G-X-G motif; other site
715451001338	PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915
715451001339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451001340	active site
715451001341	phosphorylation site [posttranslational modification]
715451001342	intermolecular recognition site; other site
715451001343	dimerization interface [polypeptide binding]; other site
715451001344	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451001345	Walker A motif; other site
715451001346	ATP binding site [chemical binding]; other site
715451001347	Walker B motif; other site
715451001348	arginine finger; other site
715451001349	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
715451001350	Tetratricopeptide repeat; Region: TPR_12; pfam13424
715451001351	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451001352	binding surface
715451001353	TPR motif; other site
715451001354	Tetratricopeptide repeat; Region: TPR_12; pfam13424
715451001355	Tetratricopeptide repeat; Region: TPR_12; pfam13424
715451001356	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451001357	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451001358	metal binding site [ion binding]; metal-binding site
715451001359	active site
715451001360	I-site; other site
715451001361	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
715451001362	catalytic triad [active]
715451001363	dimer interface [polypeptide binding]; other site
715451001364	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
715451001365	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
715451001366	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
715451001367	Outer membrane efflux protein; Region: OEP; pfam02321
715451001368	Outer membrane efflux protein; Region: OEP; pfam02321
715451001369	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
715451001370	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451001371	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
715451001372	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
715451001373	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
715451001374	active site
715451001375	dimer interface [polypeptide binding]; other site
715451001376	SapC; Region: SapC; pfam07277
715451001377	cell division protein MraZ; Reviewed; Region: PRK00326
715451001378	MraZ protein; Region: MraZ; pfam02381
715451001379	MraZ protein; Region: MraZ; pfam02381
715451001380	MraW methylase family; Region: Methyltransf_5; pfam01795
715451001381	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
715451001382	Cell division protein FtsL; Region: FtsL; pfam04999
715451001383	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
715451001384	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
715451001385	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
715451001386	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
715451001387	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
715451001388	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
715451001389	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
715451001390	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
715451001391	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
715451001392	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
715451001393	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
715451001394	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
715451001395	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
715451001396	Mg++ binding site [ion binding]; other site
715451001397	putative catalytic motif [active]
715451001398	putative substrate binding site [chemical binding]; other site
715451001399	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
715451001400	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
715451001401	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
715451001402	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
715451001403	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
715451001404	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
715451001405	active site
715451001406	homodimer interface [polypeptide binding]; other site
715451001407	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
715451001408	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
715451001409	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
715451001410	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
715451001411	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
715451001412	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
715451001413	ATP-grasp domain; Region: ATP-grasp_4; cl17255
715451001414	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
715451001415	Cell division protein FtsQ; Region: FtsQ; pfam03799
715451001416	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
715451001417	Cell division protein FtsA; Region: FtsA; pfam14450
715451001418	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
715451001419	Cell division protein FtsA; Region: FtsA; pfam14450
715451001420	cell division protein FtsZ; Validated; Region: PRK09330
715451001421	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
715451001422	nucleotide binding site [chemical binding]; other site
715451001423	SulA interaction site; other site
715451001424	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
715451001425	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
715451001426	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
715451001427	Peptidase family M23; Region: Peptidase_M23; pfam01551
715451001428	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
715451001429	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
715451001430	SEC-C motif; Region: SEC-C; pfam02810
715451001431	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
715451001432	active site
715451001433	8-oxo-dGMP binding site [chemical binding]; other site
715451001434	nudix motif; other site
715451001435	metal binding site [ion binding]; metal-binding site
715451001436	aspartoacylase; Provisional; Region: PRK02259
715451001437	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
715451001438	Domain of unknown function (DUF329); Region: DUF329; pfam03884
715451001439	hypothetical protein; Provisional; Region: PRK05287
715451001440	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
715451001441	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
715451001442	CoA-binding site [chemical binding]; other site
715451001443	ATP-binding [chemical binding]; other site
715451001444	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
715451001445	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
715451001446	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
715451001447	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
715451001448	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
715451001449	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
715451001450	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
715451001451	Pilin (bacterial filament); Region: Pilin; pfam00114
715451001452	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
715451001453	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
715451001454	dimerization interface [polypeptide binding]; other site
715451001455	active site
715451001456	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
715451001457	catalytic motif [active]
715451001458	Catalytic residue [active]
715451001459	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
715451001460	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
715451001461	amidase catalytic site [active]
715451001462	Zn binding residues [ion binding]; other site
715451001463	substrate binding site [chemical binding]; other site
715451001464	regulatory protein AmpE; Provisional; Region: PRK10987
715451001465	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
715451001466	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
715451001467	DNA-binding site [nucleotide binding]; DNA binding site
715451001468	FCD domain; Region: FCD; pfam07729
715451001469	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
715451001470	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
715451001471	dimer interface [polypeptide binding]; other site
715451001472	TPP-binding site [chemical binding]; other site
715451001473	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
715451001474	E3 interaction surface; other site
715451001475	lipoyl attachment site [posttranslational modification]; other site
715451001476	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
715451001477	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
715451001478	E3 interaction surface; other site
715451001479	lipoyl attachment site [posttranslational modification]; other site
715451001480	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
715451001481	E3 interaction surface; other site
715451001482	lipoyl attachment site [posttranslational modification]; other site
715451001483	e3 binding domain; Region: E3_binding; pfam02817
715451001484	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
715451001485	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
715451001486	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
715451001487	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
715451001488	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
715451001489	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
715451001490	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451001491	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
715451001492	substrate binding pocket [chemical binding]; other site
715451001493	dimerization interface [polypeptide binding]; other site
715451001494	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
715451001495	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
715451001496	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451001497	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
715451001498	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
715451001499	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
715451001500	FeS/SAM binding site; other site
715451001501	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
715451001502	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
715451001503	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
715451001504	HDOD domain; Region: HDOD; pfam08668
715451001505	Protein of unknown function, DUF481; Region: DUF481; pfam04338
715451001506	Protein of unknown function, DUF481; Region: DUF481; pfam04338
715451001507	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
715451001508	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
715451001509	ligand binding site [chemical binding]; other site
715451001510	NAD binding site [chemical binding]; other site
715451001511	tetramer interface [polypeptide binding]; other site
715451001512	catalytic site [active]
715451001513	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
715451001514	L-serine binding site [chemical binding]; other site
715451001515	ACT domain interface; other site
715451001516	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
715451001517	tetramer (dimer of dimers) interface [polypeptide binding]; other site
715451001518	active site
715451001519	dimer interface [polypeptide binding]; other site
715451001520	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
715451001521	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
715451001522	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
715451001523	GAF domain; Region: GAF; pfam01590
715451001524	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451001525	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451001526	dimer interface [polypeptide binding]; other site
715451001527	phosphorylation site [posttranslational modification]
715451001528	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451001529	ATP binding site [chemical binding]; other site
715451001530	Mg2+ binding site [ion binding]; other site
715451001531	G-X-G motif; other site
715451001532	Response regulator receiver domain; Region: Response_reg; pfam00072
715451001533	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451001534	active site
715451001535	phosphorylation site [posttranslational modification]
715451001536	intermolecular recognition site; other site
715451001537	dimerization interface [polypeptide binding]; other site
715451001538	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
715451001539	active site
715451001540	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
715451001541	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
715451001542	substrate binding site [chemical binding]; other site
715451001543	dimer interface [polypeptide binding]; other site
715451001544	ATP binding site [chemical binding]; other site
715451001545	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
715451001546	proline aminopeptidase P II; Provisional; Region: PRK10879
715451001547	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
715451001548	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
715451001549	active site
715451001550	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
715451001551	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
715451001552	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
715451001553	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
715451001554	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
715451001555	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
715451001556	PA/protease or protease-like domain interface [polypeptide binding]; other site
715451001557	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
715451001558	Peptidase family M28; Region: Peptidase_M28; pfam04389
715451001559	metal binding site [ion binding]; metal-binding site
715451001560	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
715451001561	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
715451001562	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
715451001563	active site
715451001564	Necrosis inducing protein (NPP1); Region: NPP1; pfam05630
715451001565	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451001566	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451001567	LysR substrate binding domain; Region: LysR_substrate; pfam03466
715451001568	dimerization interface [polypeptide binding]; other site
715451001569	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
715451001570	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
715451001571	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
715451001572	lipoyl attachment site [posttranslational modification]; other site
715451001573	glycine dehydrogenase; Provisional; Region: PRK05367
715451001574	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
715451001575	tetramer interface [polypeptide binding]; other site
715451001576	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451001577	catalytic residue [active]
715451001578	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
715451001579	tetramer interface [polypeptide binding]; other site
715451001580	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451001581	catalytic residue [active]
715451001582	hypothetical protein; Provisional; Region: PRK06762
715451001583	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
715451001584	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
715451001585	Transposase [DNA replication, recombination, and repair]; Region: COG5433
715451001586	Transposase [DNA replication, recombination, and repair]; Region: COG5433
715451001587	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_5; cd13145
715451001588	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
715451001589	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
715451001590	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
715451001591	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
715451001592	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
715451001593	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
715451001594	active site
715451001595	catalytic tetrad [active]
715451001596	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
715451001597	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
715451001598	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451001599	putative substrate translocation pore; other site
715451001600	Protein of unknown function (DUF3010); Region: DUF3010; pfam11215
715451001601	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA_subfamily_ECM; cd01450
715451001602	integrin inhibitor binding pocket; other site
715451001603	metal ion-dependent adhesion site (MIDAS); other site
715451001604	integrin-collagen binding site; other site
715451001605	putative vWF-collagen binding site; other site
715451001606	glycoprotein Ib (GpIb) binding site [polypeptide binding]; other site
715451001607	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
715451001608	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451001609	TPR motif; other site
715451001610	binding surface
715451001611	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451001612	binding surface
715451001613	TPR motif; other site
715451001614	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
715451001615	binding surface
715451001616	TPR motif; other site
715451001617	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
715451001618	binding surface
715451001619	TPR motif; other site
715451001620	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451001621	binding surface
715451001622	TPR motif; other site
715451001623	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
715451001624	helicase 45; Provisional; Region: PTZ00424
715451001625	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
715451001626	ATP binding site [chemical binding]; other site
715451001627	Mg++ binding site [ion binding]; other site
715451001628	motif III; other site
715451001629	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451001630	nucleotide binding region [chemical binding]; other site
715451001631	ATP-binding site [chemical binding]; other site
715451001632	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
715451001633	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
715451001634	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
715451001635	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
715451001636	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
715451001637	conserved cys residue [active]
715451001638	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
715451001639	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
715451001640	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
715451001641	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
715451001642	Nidogen-like; Region: NIDO; cl02648
715451001643	RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248
715451001644	ATP binding site [chemical binding]; other site
715451001645	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
715451001646	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451001647	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
715451001648	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
715451001649	Walker A/P-loop; other site
715451001650	ATP binding site [chemical binding]; other site
715451001651	Q-loop/lid; other site
715451001652	ABC transporter signature motif; other site
715451001653	Walker B; other site
715451001654	D-loop; other site
715451001655	H-loop/switch region; other site
715451001656	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
715451001657	FtsX-like permease family; Region: FtsX; pfam02687
715451001658	FtsX-like permease family; Region: FtsX; pfam02687
715451001659	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
715451001660	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451001661	active site
715451001662	phosphorylation site [posttranslational modification]
715451001663	intermolecular recognition site; other site
715451001664	dimerization interface [polypeptide binding]; other site
715451001665	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451001666	Walker A motif; other site
715451001667	ATP binding site [chemical binding]; other site
715451001668	Walker B motif; other site
715451001669	arginine finger; other site
715451001670	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
715451001671	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451001672	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451001673	dimer interface [polypeptide binding]; other site
715451001674	phosphorylation site [posttranslational modification]
715451001675	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451001676	ATP binding site [chemical binding]; other site
715451001677	Mg2+ binding site [ion binding]; other site
715451001678	G-X-G motif; other site
715451001679	2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291
715451001680	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
715451001681	NADP binding site [chemical binding]; other site
715451001682	dimer interface [polypeptide binding]; other site
715451001683	Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney,  using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144
715451001684	putative FMN binding site [chemical binding]; other site
715451001685	putative dimer interface [polypeptide binding]; other site
715451001686	SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102
715451001687	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
715451001688	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
715451001689	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
715451001690	catalytic site [active]
715451001691	active site
715451001692	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
715451001693	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
715451001694	dimerization interface [polypeptide binding]; other site
715451001695	FOG: CBS domain [General function prediction only]; Region: COG0517
715451001696	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
715451001697	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
715451001698	Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111
715451001699	N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476
715451001700	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
715451001701	YHYH protein; Region: YHYH; pfam14240
715451001702	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
715451001703	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
715451001704	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
715451001705	DNA-binding site [nucleotide binding]; DNA binding site
715451001706	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
715451001707	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451001708	homodimer interface [polypeptide binding]; other site
715451001709	catalytic residue [active]
715451001710	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451001711	DNA binding site [nucleotide binding]
715451001712	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
715451001713	putative sugar binding sites [chemical binding]; other site
715451001714	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
715451001715	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
715451001716	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
715451001717	HSP70 interaction site [polypeptide binding]; other site
715451001718	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
715451001719	substrate binding site [polypeptide binding]; other site
715451001720	dimer interface [polypeptide binding]; other site
715451001721	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
715451001722	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
715451001723	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
715451001724	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451001725	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
715451001726	dimerization interface [polypeptide binding]; other site
715451001727	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
715451001728	YaeQ protein; Region: YaeQ; pfam07152
715451001729	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
715451001730	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
715451001731	ATP binding site [chemical binding]; other site
715451001732	putative Mg++ binding site [ion binding]; other site
715451001733	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451001734	nucleotide binding region [chemical binding]; other site
715451001735	ATP-binding site [chemical binding]; other site
715451001736	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
715451001737	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
715451001738	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
715451001739	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
715451001740	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451001741	Q-loop/lid; other site
715451001742	ABC transporter signature motif; other site
715451001743	Walker B; other site
715451001744	D-loop; other site
715451001745	H-loop/switch region; other site
715451001746	transcriptional regulator SlyA; Provisional; Region: PRK03573
715451001747	MarR family; Region: MarR_2; pfam12802
715451001748	MarR family; Region: MarR_2; cl17246
715451001749	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
715451001750	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
715451001751	Protein of unknown function (DUF2955); Region: DUF2955; pfam11168
715451001752	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
715451001753	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451001754	N-terminal plug; other site
715451001755	ligand-binding site [chemical binding]; other site
715451001756	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
715451001757	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
715451001758	Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695
715451001759	intracellular protease, PfpI family; Region: PfpI; TIGR01382
715451001760	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
715451001761	proposed catalytic triad [active]
715451001762	conserved cys residue [active]
715451001763	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
715451001764	classical (c) SDRs; Region: SDR_c; cd05233
715451001765	NAD(P) binding site [chemical binding]; other site
715451001766	active site
715451001767	Domain of unknown function (DUF305); Region: DUF305; cl17794
715451001768	hypothetical protein; Provisional; Region: PRK11469
715451001769	Domain of unknown function DUF; Region: DUF204; pfam02659
715451001770	Domain of unknown function DUF; Region: DUF204; pfam02659
715451001771	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
715451001772	UbiA prenyltransferase family; Region: UbiA; pfam01040
715451001773	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
715451001774	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
715451001775	Subunit III/IV interface [polypeptide binding]; other site
715451001776	Subunit I/III interface [polypeptide binding]; other site
715451001777	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
715451001778	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
715451001779	D-pathway; other site
715451001780	Putative ubiquinol binding site [chemical binding]; other site
715451001781	Low-spin heme (heme b) binding site [chemical binding]; other site
715451001782	Putative water exit pathway; other site
715451001783	Binuclear center (heme o3/CuB) [ion binding]; other site
715451001784	K-pathway; other site
715451001785	Putative proton exit pathway; other site
715451001786	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
715451001787	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
715451001788	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
715451001789	hypothetical protein; Provisional; Region: PRK06194
715451001790	classical (c) SDRs; Region: SDR_c; cd05233
715451001791	NAD(P) binding site [chemical binding]; other site
715451001792	active site
715451001793	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
715451001794	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
715451001795	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451001796	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
715451001797	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
715451001798	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
715451001799	Peptidase family M1; Region: Peptidase_M1; pfam01433
715451001800	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
715451001801	Zn binding site [ion binding]; other site
715451001802	oxidoreductase; Provisional; Region: PRK06128
715451001803	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
715451001804	NAD binding site [chemical binding]; other site
715451001805	metal binding site [ion binding]; metal-binding site
715451001806	active site
715451001807	hypothetical protein; Provisional; Region: PRK11019
715451001808	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
715451001809	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
715451001810	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
715451001811	Penicillinase repressor; Region: Pencillinase_R; pfam03965
715451001812	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
715451001813	Predicted transcriptional regulators [Transcription]; Region: COG1733
715451001814	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
715451001815	classical (c) SDRs; Region: SDR_c; cd05233
715451001816	NAD(P) binding site [chemical binding]; other site
715451001817	active site
715451001818	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
715451001819	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
715451001820	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
715451001821	catalytic residue [active]
715451001822	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
715451001823	homotrimer interaction site [polypeptide binding]; other site
715451001824	putative active site [active]
715451001825	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451001826	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451001827	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451001828	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
715451001829	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451001830	putative substrate translocation pore; other site
715451001831	sucrose phosphorylase; Provisional; Region: PRK13840
715451001832	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
715451001833	active site
715451001834	homodimer interface [polypeptide binding]; other site
715451001835	catalytic site [active]
715451001836	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
715451001837	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
715451001838	YHYH protein; Region: YHYH; pfam14240
715451001839	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
715451001840	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
715451001841	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
715451001842	putative N-terminal domain interface [polypeptide binding]; other site
715451001843	putative dimer interface [polypeptide binding]; other site
715451001844	putative substrate binding pocket (H-site) [chemical binding]; other site
715451001845	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
715451001846	Peptidase family U32; Region: Peptidase_U32; pfam01136
715451001847	Collagenase; Region: DUF3656; pfam12392
715451001848	Peptidase family U32; Region: Peptidase_U32; cl03113
715451001849	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
715451001850	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
715451001851	adenylate cyclase; Provisional; Region: cyaA; PRK09450
715451001852	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
715451001853	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
715451001854	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
715451001855	dimer interface [polypeptide binding]; other site
715451001856	FMN binding site [chemical binding]; other site
715451001857	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451001858	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451001859	metal binding site [ion binding]; metal-binding site
715451001860	active site
715451001861	I-site; other site
715451001862	TPR repeat; Region: TPR_11; pfam13414
715451001863	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451001864	binding surface
715451001865	TPR motif; other site
715451001866	Tetratricopeptide repeat; Region: TPR_12; pfam13424
715451001867	Tetratricopeptide repeat; Region: TPR_12; pfam13424
715451001868	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
715451001869	TPR motif; other site
715451001870	binding surface
715451001871	Tetratricopeptide repeat; Region: TPR_12; pfam13424
715451001872	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
715451001873	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
715451001874	dimer interface [polypeptide binding]; other site
715451001875	active site
715451001876	metal binding site [ion binding]; metal-binding site
715451001877	glutathione binding site [chemical binding]; other site
715451001878	potential frameshift: common BLAST hit: gi|77361792|ref|YP_341367.1| secreted protein
715451001879	Protein of unknown function (DUF1439); Region: DUF1439; pfam07273
715451001880	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
715451001881	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
715451001882	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
715451001883	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
715451001884	Predicted ATPase [General function prediction only]; Region: COG1485
715451001885	Protein of unknown function (DUF3718); Region: DUF3718; pfam12514
715451001886	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
715451001887	putative catalytic residues [active]
715451001888	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
715451001889	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
715451001890	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451001891	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451001892	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
715451001893	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
715451001894	active site
715451001895	dimer interface [polypeptide binding]; other site
715451001896	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
715451001897	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
715451001898	DsrE/DsrF-like family; Region: DrsE; pfam02635
715451001899	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
715451001900	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
715451001901	active site
715451001902	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
715451001903	YHYH protein; Region: YHYH; pfam14240
715451001904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
715451001905	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
715451001906	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
715451001907	Cu(I) binding site [ion binding]; other site
715451001908	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
715451001909	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451001910	active site
715451001911	phosphorylation site [posttranslational modification]
715451001912	intermolecular recognition site; other site
715451001913	dimerization interface [polypeptide binding]; other site
715451001914	LytTr DNA-binding domain; Region: LytTR; smart00850
715451001915	Histidine kinase; Region: His_kinase; pfam06580
715451001916	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
715451001917	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
715451001918	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
715451001919	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
715451001920	active site
715451001921	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
715451001922	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
715451001923	ligand binding site; other site
715451001924	oligomer interface; other site
715451001925	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
715451001926	N-terminal domain interface [polypeptide binding]; other site
715451001927	sulfate 1 binding site; other site
715451001928	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
715451001929	active site
715451001930	Zn binding site [ion binding]; other site
715451001931	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
715451001932	Interdomain contacts; other site
715451001933	Cytokine receptor motif; other site
715451001934	ATP-grasp domain; Region: ATP-grasp_4; cl17255
715451001935	ATP-grasp domain; Region: ATP-grasp_4; cl17255
715451001936	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
715451001937	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
715451001938	metal binding site [ion binding]; metal-binding site
715451001939	dimer interface [polypeptide binding]; other site
715451001940	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
715451001941	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
715451001942	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451001943	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
715451001944	Protein export membrane protein; Region: SecD_SecF; cl14618
715451001945	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
715451001946	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
715451001947	active site
715451001948	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
715451001949	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
715451001950	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451001951	S-adenosylmethionine binding site [chemical binding]; other site
715451001952	Predicted membrane protein [Function unknown]; Region: COG4682
715451001953	yiaA/B two helix domain; Region: YiaAB; pfam05360
715451001954	yiaA/B two helix domain; Region: YiaAB; pfam05360
715451001955	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
715451001956	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451001957	N-terminal plug; other site
715451001958	ligand-binding site [chemical binding]; other site
715451001959	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
715451001960	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
715451001961	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
715451001962	short chain dehydrogenase; Provisional; Region: PRK12937
715451001963	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
715451001964	NADP binding site [chemical binding]; other site
715451001965	homodimer interface [polypeptide binding]; other site
715451001966	active site
715451001967	substrate binding site [chemical binding]; other site
715451001968	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
715451001969	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451001970	N-terminal plug; other site
715451001971	ligand-binding site [chemical binding]; other site
715451001972	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
715451001973	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451001974	N-terminal plug; other site
715451001975	ligand-binding site [chemical binding]; other site
715451001976	Protein of unknown function (DUF962); Region: DUF962; cl01879
715451001977	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
715451001978	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
715451001979	substrate binding site [chemical binding]; other site
715451001980	oxyanion hole (OAH) forming residues; other site
715451001981	trimer interface [polypeptide binding]; other site
715451001982	RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6
715451001983	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
715451001984	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
715451001985	Catalytic domain of Protein Kinases; Region: PKc; cd00180
715451001986	active site
715451001987	ATP binding site [chemical binding]; other site
715451001988	substrate binding site [chemical binding]; other site
715451001989	activation loop (A-loop); other site
715451001990	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
715451001991	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
715451001992	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
715451001993	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
715451001994	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
715451001995	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
715451001996	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
715451001997	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
715451001998	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
715451001999	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
715451002000	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
715451002001	GTP/Mg2+ binding site [chemical binding]; other site
715451002002	G4 box; other site
715451002003	G5 box; other site
715451002004	G1 box; other site
715451002005	Switch I region; other site
715451002006	G2 box; other site
715451002007	G3 box; other site
715451002008	Switch II region; other site
715451002009	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
715451002010	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
715451002011	Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075
715451002012	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
715451002013	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
715451002014	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
715451002015	active site
715451002016	Transcriptional regulators [Transcription]; Region: PurR; COG1609
715451002017	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
715451002018	DNA binding site [nucleotide binding]
715451002019	domain linker motif; other site
715451002020	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
715451002021	putative dimerization interface [polypeptide binding]; other site
715451002022	putative ligand binding site [chemical binding]; other site
715451002023	thymidine kinase; Provisional; Region: PRK04296
715451002024	potential frameshift: common BLAST hit: gi|196157427|ref|YP_002126916.1| GGDEF/EAL domain-containing protein
715451002025	acyl-CoA dehydrogenase; Reviewed; Region: PRK13026
715451002026	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
715451002027	active site
715451002028	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
715451002029	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
715451002030	Protein export membrane protein; Region: SecD_SecF; cl14618
715451002031	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
715451002032	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
715451002033	Protein of unknown function (DUF3081); Region: DUF3081; pfam11280
715451002034	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
715451002035	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
715451002036	putative acyl-acceptor binding pocket; other site
715451002037	Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671
715451002038	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
715451002039	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
715451002040	metal binding triad; other site
715451002041	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
715451002042	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
715451002043	metal binding triad; other site
715451002044	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
715451002045	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
715451002046	GIY-YIG motif/motif A; other site
715451002047	putative active site [active]
715451002048	putative metal binding site [ion binding]; other site
715451002049	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
715451002050	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
715451002051	putative ribose interaction site [chemical binding]; other site
715451002052	putative ADP binding site [chemical binding]; other site
715451002053	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
715451002054	active site
715451002055	nucleotide binding site [chemical binding]; other site
715451002056	HIGH motif; other site
715451002057	KMSKS motif; other site
715451002058	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
715451002059	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451002060	Walker A motif; other site
715451002061	ATP binding site [chemical binding]; other site
715451002062	Walker B motif; other site
715451002063	arginine finger; other site
715451002064	uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016
715451002065	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
715451002066	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
715451002067	Chain length determinant protein; Region: Wzz; pfam02706
715451002068	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
715451002069	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
715451002070	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
715451002071	SLBB domain; Region: SLBB; pfam10531
715451002072	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
715451002073	Bacterial sugar transferase; Region: Bac_transf; pfam02397
715451002074	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
715451002075	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
715451002076	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
715451002077	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
715451002078	O-Antigen ligase; Region: Wzy_C; cl04850
715451002079	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
715451002080	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
715451002081	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
715451002082	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
715451002083	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
715451002084	active site
715451002085	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
715451002086	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
715451002087	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
715451002088	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
715451002089	active site
715451002090	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
715451002091	Acyltransferase family; Region: Acyl_transf_3; pfam01757
715451002092	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
715451002093	putative catalytic site [active]
715451002094	putative metal binding site [ion binding]; other site
715451002095	putative phosphate binding site [ion binding]; other site
715451002096	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
715451002097	colanic acid exporter; Provisional; Region: PRK10459
715451002098	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
715451002099	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
715451002100	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
715451002101	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
715451002102	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
715451002103	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
715451002104	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
715451002105	putative active site [active]
715451002106	putative metal binding site [ion binding]; other site
715451002107	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
715451002108	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
715451002109	DXD motif; other site
715451002110	serine O-acetyltransferase; Region: cysE; TIGR01172
715451002111	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
715451002112	trimer interface [polypeptide binding]; other site
715451002113	active site
715451002114	substrate binding site [chemical binding]; other site
715451002115	CoA binding site [chemical binding]; other site
715451002116	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
715451002117	hypothetical protein; Validated; Region: PRK08223
715451002118	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
715451002119	ATP binding site [chemical binding]; other site
715451002120	substrate interface [chemical binding]; other site
715451002121	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
715451002122	Uncharacterized conserved protein [Function unknown]; Region: COG1434
715451002123	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
715451002124	putative active site [active]
715451002125	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
715451002126	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
715451002127	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
715451002128	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
715451002129	putative NAD(P) binding site [chemical binding]; other site
715451002130	active site
715451002131	putative substrate binding site [chemical binding]; other site
715451002132	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
715451002133	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
715451002134	active site
715451002135	nucleophile elbow; other site
715451002136	malate synthase G; Provisional; Region: PRK02999
715451002137	active site
715451002138	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451002139	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451002140	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
715451002141	substrate binding pocket [chemical binding]; other site
715451002142	dimerization interface [polypeptide binding]; other site
715451002143	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
715451002144	tetramer interface [polypeptide binding]; other site
715451002145	active site
715451002146	Mg2+/Mn2+ binding site [ion binding]; other site
715451002147	isocitrate lyase; Region: PLN02892
715451002148	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
715451002149	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451002150	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451002151	active site
715451002152	phosphorylation site [posttranslational modification]
715451002153	intermolecular recognition site; other site
715451002154	dimerization interface [polypeptide binding]; other site
715451002155	Alkaline phosphatase homologues; Region: alkPPc; smart00098
715451002156	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
715451002157	active site
715451002158	dimer interface [polypeptide binding]; other site
715451002159	glutaminase; Provisional; Region: PRK00971
715451002160	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
715451002161	Rhomboid family; Region: Rhomboid; pfam01694
715451002162	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
715451002163	Protein of unknown function (DUF1190); Region: DUF1190; cl10031
715451002164	Predicted membrane protein [Function unknown]; Region: COG3766
715451002165	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
715451002166	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
715451002167	Ion channel; Region: Ion_trans_2; pfam07885
715451002168	PspA/IM30 family; Region: PspA_IM30; pfam04012
715451002169	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938
715451002170	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
715451002171	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
715451002172	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
715451002173	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
715451002174	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
715451002175	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
715451002176	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
715451002177	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
715451002178	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
715451002179	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
715451002180	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
715451002181	Protein export membrane protein; Region: SecD_SecF; pfam02355
715451002182	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
715451002183	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451002184	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
715451002185	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
715451002186	dimerization interface [polypeptide binding]; other site
715451002187	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451002188	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451002189	metal binding site [ion binding]; metal-binding site
715451002190	active site
715451002191	I-site; other site
715451002192	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451002193	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
715451002194	LytTr DNA-binding domain; Region: LytTR; smart00850
715451002195	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
715451002196	Acyltransferase family; Region: Acyl_transf_3; pfam01757
715451002197	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
715451002198	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
715451002199	active site
715451002200	dimerization interface [polypeptide binding]; other site
715451002201	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
715451002202	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
715451002203	serine O-acetyltransferase; Region: cysE; TIGR01172
715451002204	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
715451002205	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
715451002206	trimer interface [polypeptide binding]; other site
715451002207	active site
715451002208	substrate binding site [chemical binding]; other site
715451002209	CoA binding site [chemical binding]; other site
715451002210	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
715451002211	Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292
715451002212	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
715451002213	Family description; Region: VCBS; pfam13517
715451002214	Family description; Region: VCBS; pfam13517
715451002215	Family description; Region: VCBS; pfam13517
715451002216	FG-GAP repeat; Region: FG-GAP; pfam01839
715451002217	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
715451002218	PEP-CTERM motif; Region: VPEP; pfam07589
715451002219	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
715451002220	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
715451002221	LVIVD repeat; Region: LVIVD; pfam08309
715451002222	Uncharacterized conserved protein [Function unknown]; Region: COG5276
715451002223	LVIVD repeat; Region: LVIVD; pfam08309
715451002224	LVIVD repeat; Region: LVIVD; pfam08309
715451002225	Bacterial Ig-like domain; Region: Big_5; pfam13205
715451002226	Bacterial Ig-like domain; Region: Big_5; pfam13205
715451002227	Bacterial Ig-like domain; Region: Big_5; pfam13205
715451002228	Bacterial Ig-like domain; Region: Big_5; pfam13205
715451002229	Bacterial Ig-like domain; Region: Big_5; pfam13205
715451002230	Bacterial Ig-like domain; Region: Big_5; pfam13205
715451002231	Bacterial Ig-like domain; Region: Big_5; pfam13205
715451002232	Bacterial Ig-like domain; Region: Big_5; pfam13205
715451002233	Bacterial Ig-like domain; Region: Big_5; pfam13205
715451002234	Bacterial Ig-like domain; Region: Big_5; pfam13205
715451002235	Bacterial Ig-like domain; Region: Big_5; pfam13205
715451002236	Bacterial Ig-like domain; Region: Big_5; pfam13205
715451002237	Bacterial Ig-like domain; Region: Big_5; pfam13205
715451002238	Bacterial Ig-like domain; Region: Big_5; pfam13205
715451002239	Bacterial Ig-like domain; Region: Big_5; pfam13205
715451002240	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
715451002241	Transcriptional regulator; Region: Rrf2; cl17282
715451002242	Rrf2 family protein; Region: rrf2_super; TIGR00738
715451002243	cysteine desulfurase; Provisional; Region: PRK14012
715451002244	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
715451002245	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
715451002246	catalytic residue [active]
715451002247	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
715451002248	putative ABC transporter; Region: ycf24; CHL00085
715451002249	FeS assembly ATPase SufC; Region: sufC; TIGR01978
715451002250	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
715451002251	Walker A/P-loop; other site
715451002252	ATP binding site [chemical binding]; other site
715451002253	Q-loop/lid; other site
715451002254	ABC transporter signature motif; other site
715451002255	Walker B; other site
715451002256	D-loop; other site
715451002257	H-loop/switch region; other site
715451002258	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
715451002259	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
715451002260	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
715451002261	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
715451002262	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
715451002263	catalytic residue [active]
715451002264	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
715451002265	probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406
715451002266	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
715451002267	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
715451002268	active site
715451002269	multimer interface [polypeptide binding]; other site
715451002270	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
715451002271	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
715451002272	FeS/SAM binding site; other site
715451002273	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
715451002274	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451002275	TPR motif; other site
715451002276	binding surface
715451002277	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451002278	TPR motif; other site
715451002279	binding surface
715451002280	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
715451002281	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
715451002282	non-specific DNA binding site [nucleotide binding]; other site
715451002283	salt bridge; other site
715451002284	sequence-specific DNA binding site [nucleotide binding]; other site
715451002285	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
715451002286	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
715451002287	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
715451002288	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
715451002289	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
715451002290	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
715451002291	dimer interface [polypeptide binding]; other site
715451002292	motif 1; other site
715451002293	active site
715451002294	motif 2; other site
715451002295	motif 3; other site
715451002296	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
715451002297	anticodon binding site; other site
715451002298	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
715451002299	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
715451002300	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
715451002301	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
715451002302	Trp docking motif [polypeptide binding]; other site
715451002303	active site
715451002304	GTP-binding protein Der; Reviewed; Region: PRK00093
715451002305	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
715451002306	G1 box; other site
715451002307	GTP/Mg2+ binding site [chemical binding]; other site
715451002308	Switch I region; other site
715451002309	G2 box; other site
715451002310	Switch II region; other site
715451002311	G3 box; other site
715451002312	G4 box; other site
715451002313	G5 box; other site
715451002314	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
715451002315	G1 box; other site
715451002316	GTP/Mg2+ binding site [chemical binding]; other site
715451002317	Switch I region; other site
715451002318	G2 box; other site
715451002319	G3 box; other site
715451002320	Switch II region; other site
715451002321	G4 box; other site
715451002322	G5 box; other site
715451002323	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
715451002324	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
715451002325	generic binding surface II; other site
715451002326	generic binding surface I; other site
715451002327	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
715451002328	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
715451002329	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
715451002330	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
715451002331	active site
715451002332	GMP synthase; Reviewed; Region: guaA; PRK00074
715451002333	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
715451002334	AMP/PPi binding site [chemical binding]; other site
715451002335	candidate oxyanion hole; other site
715451002336	catalytic triad [active]
715451002337	potential glutamine specificity residues [chemical binding]; other site
715451002338	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
715451002339	ATP Binding subdomain [chemical binding]; other site
715451002340	Ligand Binding sites [chemical binding]; other site
715451002341	Dimerization subdomain; other site
715451002342	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
715451002343	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
715451002344	dimer interface [polypeptide binding]; other site
715451002345	putative CheW interface [polypeptide binding]; other site
715451002346	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
715451002347	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
715451002348	putative active site [active]
715451002349	Zn binding site [ion binding]; other site
715451002350	Phospholipase A1; Region: PLA1; pfam02253
715451002351	dimerization interface [polypeptide binding]; other site
715451002352	substrate binding site [chemical binding]; other site
715451002353	active site
715451002354	calcium binding site [ion binding]; other site
715451002355	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
715451002356	prolyl-tRNA synthetase; Provisional; Region: PRK09194
715451002357	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
715451002358	dimer interface [polypeptide binding]; other site
715451002359	motif 1; other site
715451002360	active site
715451002361	motif 2; other site
715451002362	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
715451002363	putative deacylase active site [active]
715451002364	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
715451002365	active site
715451002366	motif 3; other site
715451002367	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
715451002368	anticodon binding site; other site
715451002369	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
715451002370	homodimer interaction site [polypeptide binding]; other site
715451002371	cofactor binding site; other site
715451002372	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
715451002373	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
715451002374	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
715451002375	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
715451002376	homodimer interface [polypeptide binding]; other site
715451002377	NADP binding site [chemical binding]; other site
715451002378	substrate binding site [chemical binding]; other site
715451002379	trigger factor; Provisional; Region: tig; PRK01490
715451002380	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
715451002381	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
715451002382	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
715451002383	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
715451002384	oligomer interface [polypeptide binding]; other site
715451002385	active site residues [active]
715451002386	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
715451002387	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
715451002388	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451002389	Walker A motif; other site
715451002390	ATP binding site [chemical binding]; other site
715451002391	Walker B motif; other site
715451002392	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
715451002393	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
715451002394	Found in ATP-dependent protease La (LON); Region: LON; smart00464
715451002395	Found in ATP-dependent protease La (LON); Region: LON; smart00464
715451002396	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451002397	Walker A motif; other site
715451002398	ATP binding site [chemical binding]; other site
715451002399	Walker B motif; other site
715451002400	arginine finger; other site
715451002401	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
715451002402	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
715451002403	IHF dimer interface [polypeptide binding]; other site
715451002404	IHF - DNA interface [nucleotide binding]; other site
715451002405	periplasmic folding chaperone; Provisional; Region: PRK10788
715451002406	SurA N-terminal domain; Region: SurA_N_3; cl07813
715451002407	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
715451002408	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
715451002409	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
715451002410	metal binding site [ion binding]; metal-binding site
715451002411	dimer interface [polypeptide binding]; other site
715451002412	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
715451002413	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
715451002414	putative acyl-acceptor binding pocket; other site
715451002415	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
715451002416	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
715451002417	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
715451002418	putative active site [active]
715451002419	putative metal binding site [ion binding]; other site
715451002420	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451002421	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451002422	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
715451002423	substrate binding pocket [chemical binding]; other site
715451002424	dimerization interface [polypeptide binding]; other site
715451002425	bile acid transporter; Region: bass; TIGR00841
715451002426	Sodium Bile acid symporter family; Region: SBF; cl17470
715451002427	short chain dehydrogenase; Provisional; Region: PRK05650
715451002428	classical (c) SDRs; Region: SDR_c; cd05233
715451002429	NAD(P) binding site [chemical binding]; other site
715451002430	active site
715451002431	Phosphotransferase enzyme family; Region: APH; pfam01636
715451002432	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
715451002433	putative active site [active]
715451002434	putative substrate binding site [chemical binding]; other site
715451002435	ATP binding site [chemical binding]; other site
715451002436	short chain dehydrogenase; Provisional; Region: PRK08251
715451002437	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
715451002438	NAD(P) binding site [chemical binding]; other site
715451002439	active site
715451002440	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
715451002441	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
715451002442	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
715451002443	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
715451002444	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
715451002445	active site
715451002446	Riboflavin kinase; Region: Flavokinase; smart00904
715451002447	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
715451002448	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
715451002449	active site
715451002450	HIGH motif; other site
715451002451	nucleotide binding site [chemical binding]; other site
715451002452	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
715451002453	active site
715451002454	KMSKS motif; other site
715451002455	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
715451002456	tRNA binding surface [nucleotide binding]; other site
715451002457	anticodon binding site; other site
715451002458	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
715451002459	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
715451002460	lipoprotein signal peptidase; Provisional; Region: PRK14787
715451002461	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
715451002462	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
715451002463	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
715451002464	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
715451002465	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
715451002466	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
715451002467	von Willebrand factor type A domain; Region: VWA_2; pfam13519
715451002468	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
715451002469	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
715451002470	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
715451002471	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
715451002472	hypothetical protein; Provisional; Region: PRK10557
715451002473	Type II transport protein GspH; Region: GspH; pfam12019
715451002474	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
715451002475	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
715451002476	Type II transport protein GspH; Region: GspH; pfam12019
715451002477	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
715451002478	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
715451002479	homodimer interface [polypeptide binding]; other site
715451002480	NAD binding pocket [chemical binding]; other site
715451002481	ATP binding pocket [chemical binding]; other site
715451002482	Mg binding site [ion binding]; other site
715451002483	active-site loop [active]
715451002484	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
715451002485	Nitrogen regulatory protein P-II; Region: P-II; smart00938
715451002486	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
715451002487	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
715451002488	putative global regulator; Reviewed; Region: PRK09559
715451002489	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
715451002490	Uncharacterized conserved protein [Function unknown]; Region: COG2938
715451002491	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
715451002492	active site 2 [active]
715451002493	active site 1 [active]
715451002494	L-aspartate oxidase; Provisional; Region: PRK09077
715451002495	L-aspartate oxidase; Provisional; Region: PRK06175
715451002496	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
715451002497	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
715451002498	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451002499	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
715451002500	DNA binding residues [nucleotide binding]
715451002501	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
715451002502	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
715451002503	MucB/RseB family; Region: MucB_RseB; pfam03888
715451002504	anti-sigma E factor; Provisional; Region: rseB; PRK09455
715451002505	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
715451002506	GTP-binding protein LepA; Provisional; Region: PRK05433
715451002507	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
715451002508	G1 box; other site
715451002509	putative GEF interaction site [polypeptide binding]; other site
715451002510	GTP/Mg2+ binding site [chemical binding]; other site
715451002511	Switch I region; other site
715451002512	G2 box; other site
715451002513	G3 box; other site
715451002514	Switch II region; other site
715451002515	G4 box; other site
715451002516	G5 box; other site
715451002517	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
715451002518	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
715451002519	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
715451002520	signal peptidase I; Provisional; Region: PRK10861
715451002521	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
715451002522	Catalytic site [active]
715451002523	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
715451002524	ribonuclease III; Reviewed; Region: rnc; PRK00102
715451002525	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
715451002526	dimerization interface [polypeptide binding]; other site
715451002527	active site
715451002528	metal binding site [ion binding]; metal-binding site
715451002529	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
715451002530	dsRNA binding site [nucleotide binding]; other site
715451002531	GTPase Era; Reviewed; Region: era; PRK00089
715451002532	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
715451002533	G1 box; other site
715451002534	GTP/Mg2+ binding site [chemical binding]; other site
715451002535	Switch I region; other site
715451002536	G2 box; other site
715451002537	Switch II region; other site
715451002538	G3 box; other site
715451002539	G4 box; other site
715451002540	G5 box; other site
715451002541	KH domain; Region: KH_2; pfam07650
715451002542	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
715451002543	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
715451002544	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
715451002545	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
715451002546	active site
715451002547	phosphoserine phosphatase SerB; Region: serB; TIGR00338
715451002548	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
715451002549	active site
715451002550	motif I; other site
715451002551	motif II; other site
715451002552	PilZ domain; Region: PilZ; pfam07238
715451002553	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
715451002554	DNA repair protein RadA; Provisional; Region: PRK11823
715451002555	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
715451002556	Walker A motif/ATP binding site; other site
715451002557	ATP binding site [chemical binding]; other site
715451002558	Walker B motif; other site
715451002559	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
715451002560	PilZ domain; Region: PilZ; pfam07238
715451002561	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
715451002562	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451002563	Walker A/P-loop; other site
715451002564	ATP binding site [chemical binding]; other site
715451002565	Q-loop/lid; other site
715451002566	ABC transporter signature motif; other site
715451002567	Walker B; other site
715451002568	D-loop; other site
715451002569	H-loop/switch region; other site
715451002570	ABC transporter; Region: ABC_tran_2; pfam12848
715451002571	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
715451002572	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
715451002573	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
715451002574	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
715451002575	trimer interface [polypeptide binding]; other site
715451002576	active site
715451002577	UDP-GlcNAc binding site [chemical binding]; other site
715451002578	lipid binding site [chemical binding]; lipid-binding site
715451002579	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
715451002580	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
715451002581	dimer interface [polypeptide binding]; other site
715451002582	active site
715451002583	glycine-pyridoxal phosphate binding site [chemical binding]; other site
715451002584	folate binding site [chemical binding]; other site
715451002585	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
715451002586	ATP cone domain; Region: ATP-cone; pfam03477
715451002587	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
715451002588	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
715451002589	catalytic motif [active]
715451002590	Zn binding site [ion binding]; other site
715451002591	RibD C-terminal domain; Region: RibD_C; cl17279
715451002592	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
715451002593	Lumazine binding domain; Region: Lum_binding; pfam00677
715451002594	Lumazine binding domain; Region: Lum_binding; pfam00677
715451002595	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
715451002596	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
715451002597	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
715451002598	dimerization interface [polypeptide binding]; other site
715451002599	active site
715451002600	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
715451002601	homopentamer interface [polypeptide binding]; other site
715451002602	active site
715451002603	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
715451002604	putative RNA binding site [nucleotide binding]; other site
715451002605	thiamine monophosphate kinase; Provisional; Region: PRK05731
715451002606	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
715451002607	ATP binding site [chemical binding]; other site
715451002608	dimerization interface [polypeptide binding]; other site
715451002609	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
715451002610	tetramer interfaces [polypeptide binding]; other site
715451002611	binuclear metal-binding site [ion binding]; other site
715451002612	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
715451002613	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
715451002614	TPP-binding site; other site
715451002615	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
715451002616	PYR/PP interface [polypeptide binding]; other site
715451002617	dimer interface [polypeptide binding]; other site
715451002618	TPP binding site [chemical binding]; other site
715451002619	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
715451002620	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
715451002621	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
715451002622	substrate binding pocket [chemical binding]; other site
715451002623	chain length determination region; other site
715451002624	substrate-Mg2+ binding site; other site
715451002625	catalytic residues [active]
715451002626	aspartate-rich region 1; other site
715451002627	active site lid residues [active]
715451002628	aspartate-rich region 2; other site
715451002629	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
715451002630	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
715451002631	flagellar motor protein PomA; Reviewed; Region: PRK08990
715451002632	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
715451002633	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
715451002634	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
715451002635	ligand binding site [chemical binding]; other site
715451002636	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
715451002637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451002638	S-adenosylmethionine binding site [chemical binding]; other site
715451002639	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
715451002640	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
715451002641	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
715451002642	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
715451002643	short chain dehydrogenase; Provisional; Region: PRK06101
715451002644	classical (c) SDRs; Region: SDR_c; cd05233
715451002645	NAD(P) binding site [chemical binding]; other site
715451002646	active site
715451002647	SnoaL-like domain; Region: SnoaL_2; pfam12680
715451002648	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
715451002649	RNA polymerase sigma factor; Provisional; Region: PRK11924
715451002650	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451002651	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
715451002652	DNA binding residues [nucleotide binding]
715451002653	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
715451002654	Putative zinc-finger; Region: zf-HC2; pfam13490
715451002655	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
715451002656	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
715451002657	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
715451002658	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
715451002659	RNA binding surface [nucleotide binding]; other site
715451002660	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
715451002661	active site
715451002662	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
715451002663	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
715451002664	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
715451002665	Clp amino terminal domain; Region: Clp_N; pfam02861
715451002666	Clp amino terminal domain; Region: Clp_N; pfam02861
715451002667	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451002668	Walker A motif; other site
715451002669	ATP binding site [chemical binding]; other site
715451002670	Walker B motif; other site
715451002671	arginine finger; other site
715451002672	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451002673	Walker A motif; other site
715451002674	ATP binding site [chemical binding]; other site
715451002675	Walker B motif; other site
715451002676	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
715451002677	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
715451002678	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451002679	binding surface
715451002680	TPR motif; other site
715451002681	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451002682	TPR motif; other site
715451002683	binding surface
715451002684	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451002685	binding surface
715451002686	TPR motif; other site
715451002687	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451002688	TPR motif; other site
715451002689	binding surface
715451002690	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451002691	binding surface
715451002692	TPR motif; other site
715451002693	PEP-CTERM motif; Region: VPEP; pfam07589
715451002694	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
715451002695	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
715451002696	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451002697	PAS domain; Region: PAS_9; pfam13426
715451002698	putative active site [active]
715451002699	heme pocket [chemical binding]; other site
715451002700	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451002701	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451002702	metal binding site [ion binding]; metal-binding site
715451002703	active site
715451002704	I-site; other site
715451002705	Domain of unknown function (DUF1888); Region: DUF1888; pfam08985
715451002706	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451002707	DNA binding site [nucleotide binding]
715451002708	AAA ATPase domain; Region: AAA_16; pfam13191
715451002709	Tetratricopeptide repeat; Region: TPR_12; pfam13424
715451002710	hypothetical protein; Provisional; Region: PRK05409
715451002711	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
715451002712	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
715451002713	active site
715451002714	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14949
715451002715	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451002716	Walker A motif; other site
715451002717	ATP binding site [chemical binding]; other site
715451002718	Walker B motif; other site
715451002719	arginine finger; other site
715451002720	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
715451002721	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
715451002722	hypothetical protein; Validated; Region: PRK00153
715451002723	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
715451002724	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
715451002725	active site
715451002726	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
715451002727	recombination protein RecR; Reviewed; Region: recR; PRK00076
715451002728	RecR protein; Region: RecR; pfam02132
715451002729	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
715451002730	putative active site [active]
715451002731	putative metal-binding site [ion binding]; other site
715451002732	tetramer interface [polypeptide binding]; other site
715451002733	heat shock protein 90; Provisional; Region: PRK05218
715451002734	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451002735	ATP binding site [chemical binding]; other site
715451002736	Mg2+ binding site [ion binding]; other site
715451002737	G-X-G motif; other site
715451002738	adenylate kinase; Reviewed; Region: adk; PRK00279
715451002739	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
715451002740	AMP-binding site [chemical binding]; other site
715451002741	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
715451002742	MAPEG family; Region: MAPEG; cl09190
715451002743	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451002744	ligand-binding site [chemical binding]; other site
715451002745	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
715451002746	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
715451002747	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451002748	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
715451002749	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
715451002750	Catalytic site [active]
715451002751	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
715451002752	Predicted transcriptional regulator [Transcription]; Region: COG2944
715451002753	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
715451002754	salt bridge; other site
715451002755	non-specific DNA binding site [nucleotide binding]; other site
715451002756	sequence-specific DNA binding site [nucleotide binding]; other site
715451002757	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
715451002758	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
715451002759	Coenzyme A binding pocket [chemical binding]; other site
715451002760	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
715451002761	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
715451002762	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
715451002763	metal binding site [ion binding]; metal-binding site
715451002764	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
715451002765	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
715451002766	substrate binding site [chemical binding]; other site
715451002767	glutamase interaction surface [polypeptide binding]; other site
715451002768	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
715451002769	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
715451002770	catalytic residues [active]
715451002771	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
715451002772	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
715451002773	putative active site [active]
715451002774	oxyanion strand; other site
715451002775	catalytic triad [active]
715451002776	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
715451002777	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
715451002778	active site
715451002779	motif I; other site
715451002780	motif II; other site
715451002781	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
715451002782	putative active site pocket [active]
715451002783	4-fold oligomerization interface [polypeptide binding]; other site
715451002784	metal binding residues [ion binding]; metal-binding site
715451002785	3-fold/trimer interface [polypeptide binding]; other site
715451002786	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
715451002787	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
715451002788	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451002789	homodimer interface [polypeptide binding]; other site
715451002790	catalytic residue [active]
715451002791	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
715451002792	histidinol dehydrogenase; Region: hisD; TIGR00069
715451002793	NAD binding site [chemical binding]; other site
715451002794	dimerization interface [polypeptide binding]; other site
715451002795	product binding site; other site
715451002796	substrate binding site [chemical binding]; other site
715451002797	zinc binding site [ion binding]; other site
715451002798	catalytic residues [active]
715451002799	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
715451002800	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
715451002801	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
715451002802	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
715451002803	Coenzyme A binding pocket [chemical binding]; other site
715451002804	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109
715451002805	TraB family; Region: TraB; pfam01963
715451002806	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
715451002807	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
715451002808	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
715451002809	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
715451002810	active site
715451002811	catalytic site [active]
715451002812	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
715451002813	DEAD/DEAH box helicase; Region: DEAD; pfam00270
715451002814	DEAD_2; Region: DEAD_2; pfam06733
715451002815	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
715451002816	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
715451002817	Glycoprotease family; Region: Peptidase_M22; pfam00814
715451002818	Outer membrane lipoprotein Slp family; Region: Slp; pfam03843
715451002819	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
715451002820	PGAP1-like protein; Region: PGAP1; pfam07819
715451002821	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
715451002822	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
715451002823	acyl-activating enzyme (AAE) consensus motif; other site
715451002824	putative AMP binding site [chemical binding]; other site
715451002825	putative active site [active]
715451002826	putative CoA binding site [chemical binding]; other site
715451002827	ribonuclease D; Provisional; Region: PRK10829
715451002828	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
715451002829	catalytic site [active]
715451002830	putative active site [active]
715451002831	putative substrate binding site [chemical binding]; other site
715451002832	HRDC domain; Region: HRDC; pfam00570
715451002833	YcgL domain; Region: YcgL; pfam05166
715451002834	Transglycosylase SLT domain; Region: SLT_2; pfam13406
715451002835	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
715451002836	N-acetyl-D-glucosamine binding site [chemical binding]; other site
715451002837	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
715451002838	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
715451002839	hypothetical protein; Provisional; Region: PRK05170
715451002840	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
715451002841	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
715451002842	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
715451002843	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
715451002844	fatty acid metabolism regulator; Provisional; Region: PRK04984
715451002845	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
715451002846	DNA-binding site [nucleotide binding]; DNA binding site
715451002847	FadR C-terminal domain; Region: FadR_C; pfam07840
715451002848	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
715451002849	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
715451002850	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
715451002851	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
715451002852	Domain of unknown function (DUF3336); Region: DUF3336; pfam11815
715451002853	Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Region: Pat_TGL3-4-5_SDP1; cd07206
715451002854	active site
715451002855	nucleophile elbow; other site
715451002856	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
715451002857	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
715451002858	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
715451002859	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451002860	Bacterial transcriptional repressor; Region: TetR; pfam13972
715451002861	choline dehydrogenase; Validated; Region: PRK02106
715451002862	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
715451002863	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
715451002864	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451002865	WHG domain; Region: WHG; pfam13305
715451002866	enoyl-CoA hydratase; Provisional; Region: PRK06142
715451002867	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
715451002868	substrate binding site [chemical binding]; other site
715451002869	oxyanion hole (OAH) forming residues; other site
715451002870	trimer interface [polypeptide binding]; other site
715451002871	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
715451002872	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
715451002873	active site
715451002874	FMN binding site [chemical binding]; other site
715451002875	2,4-decadienoyl-CoA binding site; other site
715451002876	catalytic residue [active]
715451002877	4Fe-4S cluster binding site [ion binding]; other site
715451002878	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
715451002879	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
715451002880	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
715451002881	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
715451002882	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
715451002883	short chain dehydrogenase; Provisional; Region: PRK09072
715451002884	classical (c) SDRs; Region: SDR_c; cd05233
715451002885	NAD(P) binding site [chemical binding]; other site
715451002886	active site
715451002887	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
715451002888	heme binding pocket [chemical binding]; other site
715451002889	heme ligand [chemical binding]; other site
715451002890	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_3; cd05914
715451002891	AMP-binding enzyme; Region: AMP-binding; pfam00501
715451002892	acyl-activating enzyme (AAE) consensus motif; other site
715451002893	putative AMP binding site [chemical binding]; other site
715451002894	putative active site [active]
715451002895	putative CoA binding site [chemical binding]; other site
715451002896	Thermostable hemolysin; Region: T_hemolysin; pfam12261
715451002897	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
715451002898	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
715451002899	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
715451002900	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
715451002901	Ligand binding site; other site
715451002902	Putative Catalytic site; other site
715451002903	DXD motif; other site
715451002904	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
715451002905	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451002906	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
715451002907	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451002908	dimer interface [polypeptide binding]; other site
715451002909	phosphorylation site [posttranslational modification]
715451002910	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451002911	ATP binding site [chemical binding]; other site
715451002912	Mg2+ binding site [ion binding]; other site
715451002913	G-X-G motif; other site
715451002914	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
715451002915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451002916	active site
715451002917	phosphorylation site [posttranslational modification]
715451002918	intermolecular recognition site; other site
715451002919	dimerization interface [polypeptide binding]; other site
715451002920	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451002921	DNA binding site [nucleotide binding]
715451002922	EamA-like transporter family; Region: EamA; cl17759
715451002923	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
715451002924	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
715451002925	putative di-iron ligands [ion binding]; other site
715451002926	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
715451002927	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
715451002928	FAD binding pocket [chemical binding]; other site
715451002929	conserved FAD binding motif [chemical binding]; other site
715451002930	phosphate binding motif [ion binding]; other site
715451002931	beta-alpha-beta structure motif; other site
715451002932	NAD binding pocket [chemical binding]; other site
715451002933	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
715451002934	catalytic loop [active]
715451002935	iron binding site [ion binding]; other site
715451002936	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
715451002937	catalytic motif [active]
715451002938	Catalytic residue [active]
715451002939	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
715451002940	active site
715451002941	Protein of unknown function, DUF462; Region: DUF462; pfam04315
715451002942	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
715451002943	YfcL protein; Region: YfcL; pfam08891
715451002944	Predicted integral membrane protein [Function unknown]; Region: COG5616
715451002945	Uncharacterized conserved protein [Function unknown]; Region: COG4121
715451002946	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
715451002947	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451002948	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451002949	metal binding site [ion binding]; metal-binding site
715451002950	active site
715451002951	I-site; other site
715451002952	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
715451002953	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
715451002954	dimer interface [polypeptide binding]; other site
715451002955	active site
715451002956	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
715451002957	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
715451002958	ligand binding site [chemical binding]; other site
715451002959	flexible hinge region; other site
715451002960	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
715451002961	aldolase II superfamily protein; Provisional; Region: PRK07044
715451002962	intersubunit interface [polypeptide binding]; other site
715451002963	active site
715451002964	Zn2+ binding site [ion binding]; other site
715451002965	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
715451002966	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
715451002967	ligand binding site [chemical binding]; other site
715451002968	NAD binding site [chemical binding]; other site
715451002969	catalytic site [active]
715451002970	homodimer interface [polypeptide binding]; other site
715451002971	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
715451002972	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
715451002973	FimV N-terminal domain; Region: FimV_core; TIGR03505
715451002974	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
715451002975	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
715451002976	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
715451002977	dimerization interface 3.5A [polypeptide binding]; other site
715451002978	active site
715451002979	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
715451002980	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
715451002981	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
715451002982	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
715451002983	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
715451002984	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
715451002985	Sporulation related domain; Region: SPOR; pfam05036
715451002986	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
715451002987	Colicin V production protein; Region: Colicin_V; cl00567
715451002988	amidophosphoribosyltransferase; Provisional; Region: PRK09246
715451002989	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
715451002990	active site
715451002991	tetramer interface [polypeptide binding]; other site
715451002992	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
715451002993	active site
715451002994	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
715451002995	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
715451002996	active site
715451002997	dinuclear metal binding site [ion binding]; other site
715451002998	dimerization interface [polypeptide binding]; other site
715451002999	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
715451003000	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
715451003001	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
715451003002	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451003003	DNA binding site [nucleotide binding]
715451003004	Predicted integral membrane protein [Function unknown]; Region: COG5616
715451003005	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
715451003006	TPR motif; other site
715451003007	binding surface
715451003008	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451003009	TPR motif; other site
715451003010	binding surface
715451003011	Protein of unknown function, DUF479; Region: DUF479; cl01203
715451003012	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451003013	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451003014	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
715451003015	putative effector binding pocket; other site
715451003016	dimerization interface [polypeptide binding]; other site
715451003017	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
715451003018	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
715451003019	putative NAD(P) binding site [chemical binding]; other site
715451003020	dimer interface [polypeptide binding]; other site
715451003021	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
715451003022	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
715451003023	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
715451003024	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
715451003025	catalytic loop [active]
715451003026	iron binding site [ion binding]; other site
715451003027	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
715451003028	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
715451003029	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
715451003030	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
715451003031	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
715451003032	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
715451003033	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
715451003034	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
715451003035	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
715451003036	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
715451003037	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
715451003038	Alkaline phosphatase homologues; Region: alkPPc; smart00098
715451003039	active site
715451003040	dimer interface [polypeptide binding]; other site
715451003041	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
715451003042	dimer interface [polypeptide binding]; other site
715451003043	Alkaline phosphatase homologues; Region: alkPPc; smart00098
715451003044	active site
715451003045	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
715451003046	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
715451003047	putative active site [active]
715451003048	putative metal binding site [ion binding]; other site
715451003049	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
715451003050	substrate binding site [chemical binding]; other site
715451003051	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
715451003052	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
715451003053	active site
715451003054	HIGH motif; other site
715451003055	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
715451003056	KMSKS motif; other site
715451003057	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
715451003058	tRNA binding surface [nucleotide binding]; other site
715451003059	anticodon binding site; other site
715451003060	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
715451003061	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451003062	N-terminal plug; other site
715451003063	ligand-binding site [chemical binding]; other site
715451003064	Ion transport protein; Region: Ion_trans; pfam00520
715451003065	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
715451003066	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
715451003067	N-acetyl-D-glucosamine binding site [chemical binding]; other site
715451003068	catalytic residue [active]
715451003069	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
715451003070	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
715451003071	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
715451003072	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
715451003073	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
715451003074	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
715451003075	Methyltransferase domain; Region: Methyltransf_11; pfam08241
715451003076	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
715451003077	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
715451003078	active site
715451003079	HIGH motif; other site
715451003080	KMSKS motif; other site
715451003081	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
715451003082	anticodon binding site; other site
715451003083	tRNA binding surface [nucleotide binding]; other site
715451003084	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
715451003085	dimer interface [polypeptide binding]; other site
715451003086	putative tRNA-binding site [nucleotide binding]; other site
715451003087	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
715451003088	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
715451003089	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
715451003090	trimer interface [polypeptide binding]; other site
715451003091	active site
715451003092	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
715451003093	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
715451003094	transmembrane helices; other site
715451003095	Replicase family; Region: Replicase; pfam03090
715451003096	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
715451003097	Helix-turn-helix domain; Region: HTH_17; pfam12728
715451003098	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
715451003099	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
715451003100	non-specific DNA binding site [nucleotide binding]; other site
715451003101	salt bridge; other site
715451003102	sequence-specific DNA binding site [nucleotide binding]; other site
715451003103	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
715451003104	active site
715451003105	catalytic residues [active]
715451003106	DNA binding site [nucleotide binding]
715451003107	Int/Topo IB signature motif; other site
715451003108	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
715451003109	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
715451003110	Family description; Region: UvrD_C_2; pfam13538
715451003111	AAA domain; Region: AAA_21; pfam13304
715451003112	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451003113	ABC transporter signature motif; other site
715451003114	Walker B; other site
715451003115	D-loop; other site
715451003116	H-loop/switch region; other site
715451003117	Restriction endonuclease; Region: Mrr_cat; pfam04471
715451003118	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
715451003119	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
715451003120	active site
715451003121	Int/Topo IB signature motif; other site
715451003122	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
715451003123	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
715451003124	active site
715451003125	Int/Topo IB signature motif; other site
715451003126	DNA binding site [nucleotide binding]
715451003127	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
715451003128	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
715451003129	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
715451003130	potential frameshift: common BLAST hit: gi|117921403|ref|YP_870595.1| type I restriction enzyme EcoKI subunit R
715451003131	Fic family protein [Function unknown]; Region: COG3177
715451003132	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
715451003133	Fic/DOC family; Region: Fic; pfam02661
715451003134	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
715451003135	putative DNA binding site [nucleotide binding]; other site
715451003136	putative Zn2+ binding site [ion binding]; other site
715451003137	potential frameshift: common BLAST hit: gi|120552975|ref|YP_957326.1| N-6 DNA methylase
715451003138	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
715451003139	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
715451003140	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
715451003141	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451003142	AAA domain; Region: AAA_23; pfam13476
715451003143	Walker A/P-loop; other site
715451003144	ATP binding site [chemical binding]; other site
715451003145	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
715451003146	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
715451003147	Integrase core domain; Region: rve; pfam00665
715451003148	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
715451003149	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451003150	Walker A motif; other site
715451003151	ATP binding site [chemical binding]; other site
715451003152	Walker B motif; other site
715451003153	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451003154	AAA domain; Region: AAA_21; pfam13304
715451003155	ABC transporter signature motif; other site
715451003156	Walker B; other site
715451003157	D-loop; other site
715451003158	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
715451003159	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
715451003160	Integrase core domain; Region: rve; pfam00665
715451003161	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
715451003162	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451003163	Walker A motif; other site
715451003164	ATP binding site [chemical binding]; other site
715451003165	Walker B motif; other site
715451003166	Predicted transcriptional regulators [Transcription]; Region: COG1695
715451003167	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
715451003168	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
715451003169	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
715451003170	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
715451003171	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
715451003172	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
715451003173	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
715451003174	tetramer interface [polypeptide binding]; other site
715451003175	heme binding pocket [chemical binding]; other site
715451003176	NADPH binding site [chemical binding]; other site
715451003177	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
715451003178	active site
715451003179	metal binding site [ion binding]; metal-binding site
715451003180	Cache domain; Region: Cache_1; pfam02743
715451003181	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
715451003182	dimerization interface [polypeptide binding]; other site
715451003183	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
715451003184	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
715451003185	dimer interface [polypeptide binding]; other site
715451003186	putative CheW interface [polypeptide binding]; other site
715451003187	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
715451003188	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
715451003189	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
715451003190	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
715451003191	cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776
715451003192	putative transporter; Provisional; Region: PRK03699
715451003193	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
715451003194	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
715451003195	active site
715451003196	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
715451003197	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
715451003198	active site
715451003199	putative substrate binding pocket [chemical binding]; other site
715451003200	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
715451003201	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
715451003202	putative FMN binding site [chemical binding]; other site
715451003203	CreA protein; Region: CreA; pfam05981
715451003204	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238
715451003205	putative active site [active]
715451003206	Zn binding site [ion binding]; other site
715451003207	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
715451003208	hypothetical protein; Provisional; Region: PRK09897
715451003209	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451003210	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451003211	dimer interface [polypeptide binding]; other site
715451003212	phosphorylation site [posttranslational modification]
715451003213	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451003214	ATP binding site [chemical binding]; other site
715451003215	Mg2+ binding site [ion binding]; other site
715451003216	G-X-G motif; other site
715451003217	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
715451003218	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451003219	active site
715451003220	phosphorylation site [posttranslational modification]
715451003221	intermolecular recognition site; other site
715451003222	dimerization interface [polypeptide binding]; other site
715451003223	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451003224	DNA binding site [nucleotide binding]
715451003225	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
715451003226	dimer interface [polypeptide binding]; other site
715451003227	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
715451003228	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
715451003229	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451003230	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451003231	metal binding site [ion binding]; metal-binding site
715451003232	active site
715451003233	I-site; other site
715451003234	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
715451003235	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
715451003236	E-class dimer interface [polypeptide binding]; other site
715451003237	P-class dimer interface [polypeptide binding]; other site
715451003238	active site
715451003239	Cu2+ binding site [ion binding]; other site
715451003240	Zn2+ binding site [ion binding]; other site
715451003241	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
715451003242	catalytic residues [active]
715451003243	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
715451003244	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
715451003245	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
715451003246	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
715451003247	substrate binding pocket [chemical binding]; other site
715451003248	membrane-bound complex binding site; other site
715451003249	hinge residues; other site
715451003250	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
715451003251	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
715451003252	GTP binding site; other site
715451003253	NHL repeat; Region: NHL; pfam01436
715451003254	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
715451003255	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
715451003256	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
715451003257	nucleophilic elbow; other site
715451003258	catalytic triad; other site
715451003259	Colicin V production protein; Region: Colicin_V; pfam02674
715451003260	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451003261	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451003262	metal binding site [ion binding]; metal-binding site
715451003263	active site
715451003264	I-site; other site
715451003265	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451003266	potential frameshift: common BLAST hit: gi|109896620|ref|YP_659875.1| Na+/solute symporter
715451003267	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
715451003268	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
715451003269	NAD(P) binding site [chemical binding]; other site
715451003270	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
715451003271	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
715451003272	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
715451003273	metal binding site [ion binding]; metal-binding site
715451003274	substrate binding pocket [chemical binding]; other site
715451003275	Transcriptional regulators [Transcription]; Region: PurR; COG1609
715451003276	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
715451003277	DNA binding site [nucleotide binding]
715451003278	domain linker motif; other site
715451003279	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
715451003280	putative ligand binding site [chemical binding]; other site
715451003281	putative dimerization interface [polypeptide binding]; other site
715451003282	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
715451003283	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
715451003284	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451003285	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
715451003286	potential frameshift: common BLAST hit: gi|330809458|ref|YP_004353920.1| putative outer membrane protein precursor
715451003287	potential frameshift: common BLAST hit: gi|330809458|ref|YP_004353920.1| putative outer membrane protein precursor
715451003288	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451003289	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
715451003290	Protein of unknown function (DUF465); Region: DUF465; pfam04325
715451003291	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
715451003292	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
715451003293	substrate binding site [chemical binding]; other site
715451003294	oxyanion hole (OAH) forming residues; other site
715451003295	trimer interface [polypeptide binding]; other site
715451003296	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
715451003297	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
715451003298	Zn binding site [ion binding]; other site
715451003299	Endonuclease I; Region: Endonuclease_1; pfam04231
715451003300	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
715451003301	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
715451003302	generic binding surface I; other site
715451003303	generic binding surface II; other site
715451003304	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
715451003305	putative active site [active]
715451003306	putative catalytic site [active]
715451003307	putative Mg binding site IVb [ion binding]; other site
715451003308	putative phosphate binding site [ion binding]; other site
715451003309	putative DNA binding site [nucleotide binding]; other site
715451003310	putative Mg binding site IVa [ion binding]; other site
715451003311	Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606
715451003312	WYL domain; Region: WYL; pfam13280
715451003313	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
715451003314	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451003315	dimer interface [polypeptide binding]; other site
715451003316	phosphorylation site [posttranslational modification]
715451003317	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451003318	ATP binding site [chemical binding]; other site
715451003319	Mg2+ binding site [ion binding]; other site
715451003320	G-X-G motif; other site
715451003321	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451003322	active site
715451003323	phosphorylation site [posttranslational modification]
715451003324	intermolecular recognition site; other site
715451003325	dimerization interface [polypeptide binding]; other site
715451003326	Response regulator receiver domain; Region: Response_reg; pfam00072
715451003327	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451003328	active site
715451003329	phosphorylation site [posttranslational modification]
715451003330	intermolecular recognition site; other site
715451003331	dimerization interface [polypeptide binding]; other site
715451003332	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
715451003333	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
715451003334	YqcI/YcgG family; Region: YqcI_YcgG; cl01349
715451003335	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
715451003336	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
715451003337	active site
715451003338	N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476
715451003339	YHYH protein; Region: YHYH; pfam14240
715451003340	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
715451003341	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451003342	active site
715451003343	phosphorylation site [posttranslational modification]
715451003344	intermolecular recognition site; other site
715451003345	dimerization interface [polypeptide binding]; other site
715451003346	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451003347	DNA binding site [nucleotide binding]
715451003348	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451003349	dimer interface [polypeptide binding]; other site
715451003350	phosphorylation site [posttranslational modification]
715451003351	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451003352	ATP binding site [chemical binding]; other site
715451003353	Mg2+ binding site [ion binding]; other site
715451003354	G-X-G motif; other site
715451003355	potential frameshift: common BLAST hit: gi|196156054|ref|YP_002125543.1| Endonuclease/exonuclease/phosphatase
715451003356	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
715451003357	BON domain; Region: BON; pfam04972
715451003358	BON domain; Region: BON; pfam04972
715451003359	Protein of unknown function (DUF2891); Region: DUF2891; pfam11199
715451003360	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
715451003361	pyruvate kinase; Provisional; Region: PRK05826
715451003362	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
715451003363	domain interfaces; other site
715451003364	active site
715451003365	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
715451003366	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
715451003367	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
715451003368	putative active site [active]
715451003369	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
715451003370	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
715451003371	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
715451003372	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
715451003373	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
715451003374	putative active site [active]
715451003375	phosphogluconate dehydratase; Validated; Region: PRK09054
715451003376	6-phosphogluconate dehydratase; Region: edd; TIGR01196
715451003377	glucokinase; Provisional; Region: glk; PRK00292
715451003378	glucokinase, proteobacterial type; Region: glk; TIGR00749
715451003379	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
715451003380	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
715451003381	active site
715451003382	intersubunit interface [polypeptide binding]; other site
715451003383	catalytic residue [active]
715451003384	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
715451003385	active site
715451003386	phosphate binding residues; other site
715451003387	catalytic residues [active]
715451003388	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
715451003389	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
715451003390	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
715451003391	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
715451003392	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
715451003393	glycogen branching enzyme; Provisional; Region: PRK05402
715451003394	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
715451003395	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
715451003396	active site
715451003397	catalytic site [active]
715451003398	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
715451003399	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
715451003400	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
715451003401	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
715451003402	active site
715451003403	catalytic site [active]
715451003404	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
715451003405	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
715451003406	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
715451003407	methionine sulfoxide reductase B; Provisional; Region: PRK00222
715451003408	SelR domain; Region: SelR; pfam01641
715451003409	Protein of unknown function (DUF2989); Region: DUF2989; pfam11207
715451003410	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
715451003411	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
715451003412	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
715451003413	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
715451003414	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
715451003415	putative active site [active]
715451003416	Zn binding site [ion binding]; other site
715451003417	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
715451003418	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
715451003419	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
715451003420	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
715451003421	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
715451003422	Protein of unknown function (DUF1315); Region: DUF1315; pfam07023
715451003423	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
715451003424	HD domain; Region: HD_3; cl17350
715451003425	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451003426	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451003427	active site
715451003428	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451003429	phosphorylation site [posttranslational modification]
715451003430	intermolecular recognition site; other site
715451003431	dimerization interface [polypeptide binding]; other site
715451003432	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451003433	dimer interface [polypeptide binding]; other site
715451003434	phosphorylation site [posttranslational modification]
715451003435	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451003436	ATP binding site [chemical binding]; other site
715451003437	Mg2+ binding site [ion binding]; other site
715451003438	G-X-G motif; other site
715451003439	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451003440	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451003441	active site
715451003442	phosphorylation site [posttranslational modification]
715451003443	intermolecular recognition site; other site
715451003444	dimerization interface [polypeptide binding]; other site
715451003445	Response regulator receiver domain; Region: Response_reg; pfam00072
715451003446	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451003447	active site
715451003448	phosphorylation site [posttranslational modification]
715451003449	intermolecular recognition site; other site
715451003450	dimerization interface [polypeptide binding]; other site
715451003451	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451003452	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451003453	active site
715451003454	phosphorylation site [posttranslational modification]
715451003455	intermolecular recognition site; other site
715451003456	dimerization interface [polypeptide binding]; other site
715451003457	CHASE3 domain; Region: CHASE3; pfam05227
715451003458	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451003459	dimer interface [polypeptide binding]; other site
715451003460	phosphorylation site [posttranslational modification]
715451003461	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451003462	ATP binding site [chemical binding]; other site
715451003463	Mg2+ binding site [ion binding]; other site
715451003464	G-X-G motif; other site
715451003465	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
715451003466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451003467	active site
715451003468	phosphorylation site [posttranslational modification]
715451003469	intermolecular recognition site; other site
715451003470	dimerization interface [polypeptide binding]; other site
715451003471	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451003472	Walker A motif; other site
715451003473	ATP binding site [chemical binding]; other site
715451003474	Walker B motif; other site
715451003475	arginine finger; other site
715451003476	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
715451003477	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
715451003478	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451003479	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451003480	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
715451003481	dimerization interface [polypeptide binding]; other site
715451003482	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
715451003483	active site residue [active]
715451003484	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
715451003485	dimerization interface [polypeptide binding]; other site
715451003486	putative DNA binding site [nucleotide binding]; other site
715451003487	putative Zn2+ binding site [ion binding]; other site
715451003488	hypothetical protein; Provisional; Region: PRK11027
715451003489	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451003490	LysR substrate binding domain; Region: LysR_substrate; pfam03466
715451003491	dimerization interface [polypeptide binding]; other site
715451003492	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
715451003493	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
715451003494	hypothetical protein; Provisional; Region: PRK11239
715451003495	Protein of unknown function, DUF480; Region: DUF480; pfam04337
715451003496	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
715451003497	conserved hypothetical protein; Region: MG423; TIGR00649
715451003498	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
715451003499	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
715451003500	PAS domain; Region: PAS_9; pfam13426
715451003501	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451003502	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451003503	metal binding site [ion binding]; metal-binding site
715451003504	active site
715451003505	I-site; other site
715451003506	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451003507	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
715451003508	Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932
715451003509	acyl-activating enzyme (AAE) consensus motif; other site
715451003510	putative AMP binding site [chemical binding]; other site
715451003511	putative active site [active]
715451003512	putative CoA binding site [chemical binding]; other site
715451003513	dUTPase; Region: dUTPase_2; pfam08761
715451003514	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
715451003515	active site
715451003516	homodimer interface [polypeptide binding]; other site
715451003517	metal binding site [ion binding]; metal-binding site
715451003518	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
715451003519	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
715451003520	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
715451003521	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
715451003522	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
715451003523	AAA domain; Region: AAA_30; pfam13604
715451003524	Family description; Region: UvrD_C_2; pfam13538
715451003525	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
715451003526	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
715451003527	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
715451003528	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451003529	homodimer interface [polypeptide binding]; other site
715451003530	catalytic residue [active]
715451003531	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
715451003532	Uncharacterized family of heme peroxidases, mostly bacterial; Region: peroxinectin_like_bacterial; cd09822
715451003533	putative heme binding site [chemical binding]; other site
715451003534	putative substrate binding site [chemical binding]; other site
715451003535	Uncharacterized conserved protein [Function unknown]; Region: COG3268
715451003536	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
715451003537	aminotransferase; Validated; Region: PRK07337
715451003538	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
715451003539	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451003540	homodimer interface [polypeptide binding]; other site
715451003541	catalytic residue [active]
715451003542	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
715451003543	active site
715451003544	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451003545	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451003546	dimer interface [polypeptide binding]; other site
715451003547	phosphorylation site [posttranslational modification]
715451003548	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451003549	ATP binding site [chemical binding]; other site
715451003550	Mg2+ binding site [ion binding]; other site
715451003551	G-X-G motif; other site
715451003552	Response regulator receiver domain; Region: Response_reg; pfam00072
715451003553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451003554	active site
715451003555	phosphorylation site [posttranslational modification]
715451003556	intermolecular recognition site; other site
715451003557	dimerization interface [polypeptide binding]; other site
715451003558	Response regulator receiver domain; Region: Response_reg; pfam00072
715451003559	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451003560	active site
715451003561	phosphorylation site [posttranslational modification]
715451003562	intermolecular recognition site; other site
715451003563	dimerization interface [polypeptide binding]; other site
715451003564	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
715451003565	active site
715451003566	homodimer interface [polypeptide binding]; other site
715451003567	SAM binding site [chemical binding]; other site
715451003568	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337
715451003569	putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730
715451003570	classical (c) SDRs; Region: SDR_c; cd05233
715451003571	NAD(P) binding site [chemical binding]; other site
715451003572	active site
715451003573	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
715451003574	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
715451003575	potential frameshift: common BLAST hit: gi|333895675|ref|YP_004469550.1| transposase, putative
715451003576	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
715451003577	potential frameshift: common BLAST hit: gi|333895675|ref|YP_004469550.1| transposase, putative
715451003578	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
715451003579	Transposase [DNA replication, recombination, and repair]; Region: COG5433
715451003580	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
715451003581	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
715451003582	Transposase [DNA replication, recombination, and repair]; Region: COG5433
715451003583	Transposase [DNA replication, recombination, and repair]; Region: COG5433
715451003584	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
715451003585	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
715451003586	Coenzyme A binding pocket [chemical binding]; other site
715451003587	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
715451003588	Protein of unknown function (DUF2956); Region: DUF2956; pfam11169
715451003589	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
715451003590	Putative addiction module component; Region: Unstab_antitox; pfam09720
715451003591	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
715451003592	Transposase; Region: DEDD_Tnp_IS110; pfam01548
715451003593	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
715451003594	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
715451003595	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
715451003596	Protein of unknown function (DUF1778); Region: DUF1778; cl01845
715451003597	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
715451003598	Domain of unknown function (DUF4375); Region: DUF4375; pfam14300
715451003599	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
715451003600	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
715451003601	topology modulation protein; Reviewed; Region: PRK08118
715451003602	AAA domain; Region: AAA_17; pfam13207
715451003603	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
715451003604	Winged helix-turn helix; Region: HTH_29; pfam13551
715451003605	Homeodomain-like domain; Region: HTH_32; pfam13565
715451003606	Integrase core domain; Region: rve; pfam00665
715451003607	Helix-turn-helix domain; Region: HTH_28; pfam13518
715451003608	Winged helix-turn helix; Region: HTH_29; pfam13551
715451003609	potential frameshift: common BLAST hit: gi|109899284|ref|YP_662539.1| short-chain dehydrogenase/reductase SDR
715451003610	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
715451003611	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
715451003612	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
715451003613	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
715451003614	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
715451003615	active site
715451003616	Zn binding site [ion binding]; other site
715451003617	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
715451003618	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
715451003619	ATP binding site [chemical binding]; other site
715451003620	substrate interface [chemical binding]; other site
715451003621	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
715451003622	MPT binding site; other site
715451003623	trimer interface [polypeptide binding]; other site
715451003624	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
715451003625	trimer interface [polypeptide binding]; other site
715451003626	dimer interface [polypeptide binding]; other site
715451003627	putative active site [active]
715451003628	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
715451003629	MoaE interaction surface [polypeptide binding]; other site
715451003630	MoeB interaction surface [polypeptide binding]; other site
715451003631	thiocarboxylated glycine; other site
715451003632	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
715451003633	MoaE homodimer interface [polypeptide binding]; other site
715451003634	MoaD interaction [polypeptide binding]; other site
715451003635	active site residues [active]
715451003636	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
715451003637	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
715451003638	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
715451003639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
715451003640	dimer interface [polypeptide binding]; other site
715451003641	conserved gate region; other site
715451003642	putative PBP binding loops; other site
715451003643	ABC-ATPase subunit interface; other site
715451003644	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451003645	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
715451003646	Walker A/P-loop; other site
715451003647	ATP binding site [chemical binding]; other site
715451003648	Q-loop/lid; other site
715451003649	ABC transporter signature motif; other site
715451003650	Walker B; other site
715451003651	D-loop; other site
715451003652	H-loop/switch region; other site
715451003653	TOBE domain; Region: TOBE; cl01440
715451003654	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
715451003655	FeS/SAM binding site; other site
715451003656	HemN C-terminal domain; Region: HemN_C; pfam06969
715451003657	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
715451003658	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
715451003659	active site
715451003660	catalytic triad [active]
715451003661	oxyanion hole [active]
715451003662	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
715451003663	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
715451003664	catalytic residues [active]
715451003665	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
715451003666	XdhC Rossmann domain; Region: XdhC_C; pfam13478
715451003667	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451003668	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
715451003669	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
715451003670	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
715451003671	catalytic core [active]
715451003672	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
715451003673	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
715451003674	active site
715451003675	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
715451003676	Phosphotransferase enzyme family; Region: APH; pfam01636
715451003677	putative active site [active]
715451003678	putative substrate binding site [chemical binding]; other site
715451003679	ATP binding site [chemical binding]; other site
715451003680	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
715451003681	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
715451003682	NAD(P) binding site [chemical binding]; other site
715451003683	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
715451003684	active site
715451003685	metal binding site [ion binding]; metal-binding site
715451003686	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
715451003687	classical (c) SDRs; Region: SDR_c; cd05233
715451003688	NAD(P) binding site [chemical binding]; other site
715451003689	active site
715451003690	haloalkane dehalogenase; Provisional; Region: PRK00870
715451003691	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
715451003692	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
715451003693	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
715451003694	substrate binding site [chemical binding]; other site
715451003695	oxyanion hole (OAH) forming residues; other site
715451003696	trimer interface [polypeptide binding]; other site
715451003697	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
715451003698	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
715451003699	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
715451003700	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
715451003701	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
715451003702	dimer interface [polypeptide binding]; other site
715451003703	active site
715451003704	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
715451003705	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
715451003706	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
715451003707	active site
715451003708	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
715451003709	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
715451003710	Protein of unknown function (DUF3718); Region: DUF3718; pfam12514
715451003711	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
715451003712	MarR family; Region: MarR_2; pfam12802
715451003713	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
715451003714	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
715451003715	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
715451003716	motif II; other site
715451003717	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
715451003718	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
715451003719	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
715451003720	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
715451003721	Protein of unknown function (DUF3718); Region: DUF3718; pfam12514
715451003722	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
715451003723	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451003724	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
715451003725	substrate binding pocket [chemical binding]; other site
715451003726	dimerization interface [polypeptide binding]; other site
715451003727	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
715451003728	active site 2 [active]
715451003729	active site 1 [active]
715451003730	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
715451003731	Mechanosensitive ion channel; Region: MS_channel; pfam00924
715451003732	Conserved TM helix; Region: TM_helix; pfam05552
715451003733	Mechanosensitive ion channel; Region: MS_channel; pfam00924
715451003734	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451003735	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451003736	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451003737	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
715451003738	aromatic arch; other site
715451003739	DCoH dimer interaction site [polypeptide binding]; other site
715451003740	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
715451003741	DCoH tetramer interaction site [polypeptide binding]; other site
715451003742	substrate binding site [chemical binding]; other site
715451003743	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
715451003744	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
715451003745	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
715451003746	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
715451003747	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451003748	PAS domain; Region: PAS_9; pfam13426
715451003749	putative active site [active]
715451003750	heme pocket [chemical binding]; other site
715451003751	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451003752	PAS fold; Region: PAS_3; pfam08447
715451003753	putative active site [active]
715451003754	heme pocket [chemical binding]; other site
715451003755	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451003756	dimer interface [polypeptide binding]; other site
715451003757	phosphorylation site [posttranslational modification]
715451003758	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451003759	ATP binding site [chemical binding]; other site
715451003760	Mg2+ binding site [ion binding]; other site
715451003761	G-X-G motif; other site
715451003762	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451003763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451003764	active site
715451003765	phosphorylation site [posttranslational modification]
715451003766	intermolecular recognition site; other site
715451003767	dimerization interface [polypeptide binding]; other site
715451003768	Hpt domain; Region: Hpt; pfam01627
715451003769	putative binding surface; other site
715451003770	active site
715451003771	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
715451003772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451003773	active site
715451003774	phosphorylation site [posttranslational modification]
715451003775	intermolecular recognition site; other site
715451003776	dimerization interface [polypeptide binding]; other site
715451003777	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
715451003778	Zn2+ binding site [ion binding]; other site
715451003779	Mg2+ binding site [ion binding]; other site
715451003780	ribosome maturation protein RimP; Reviewed; Region: PRK00092
715451003781	Sm and related proteins; Region: Sm_like; cl00259
715451003782	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
715451003783	putative oligomer interface [polypeptide binding]; other site
715451003784	putative RNA binding site [nucleotide binding]; other site
715451003785	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
715451003786	NusA N-terminal domain; Region: NusA_N; pfam08529
715451003787	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
715451003788	RNA binding site [nucleotide binding]; other site
715451003789	homodimer interface [polypeptide binding]; other site
715451003790	NusA-like KH domain; Region: KH_5; pfam13184
715451003791	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
715451003792	G-X-X-G motif; other site
715451003793	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
715451003794	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
715451003795	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
715451003796	translation initiation factor IF-2; Region: IF-2; TIGR00487
715451003797	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
715451003798	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
715451003799	G1 box; other site
715451003800	putative GEF interaction site [polypeptide binding]; other site
715451003801	GTP/Mg2+ binding site [chemical binding]; other site
715451003802	Switch I region; other site
715451003803	G2 box; other site
715451003804	G3 box; other site
715451003805	Switch II region; other site
715451003806	G4 box; other site
715451003807	G5 box; other site
715451003808	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
715451003809	Translation-initiation factor 2; Region: IF-2; pfam11987
715451003810	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
715451003811	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
715451003812	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
715451003813	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
715451003814	RNA binding site [nucleotide binding]; other site
715451003815	active site
715451003816	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
715451003817	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
715451003818	16S/18S rRNA binding site [nucleotide binding]; other site
715451003819	S13e-L30e interaction site [polypeptide binding]; other site
715451003820	25S rRNA binding site [nucleotide binding]; other site
715451003821	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
715451003822	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
715451003823	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451003824	PAS domain; Region: PAS_9; pfam13426
715451003825	putative active site [active]
715451003826	heme pocket [chemical binding]; other site
715451003827	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451003828	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451003829	metal binding site [ion binding]; metal-binding site
715451003830	active site
715451003831	I-site; other site
715451003832	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
715451003833	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
715451003834	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
715451003835	Predicted amidohydrolase [General function prediction only]; Region: COG0388
715451003836	putative active site [active]
715451003837	catalytic triad [active]
715451003838	putative dimer interface [polypeptide binding]; other site
715451003839	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
715451003840	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451003841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451003842	active site
715451003843	phosphorylation site [posttranslational modification]
715451003844	intermolecular recognition site; other site
715451003845	dimerization interface [polypeptide binding]; other site
715451003846	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451003847	binding surface
715451003848	TPR motif; other site
715451003849	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
715451003850	generic binding surface I; other site
715451003851	generic binding surface II; other site
715451003852	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
715451003853	putative catalytic site [active]
715451003854	putative metal binding site [ion binding]; other site
715451003855	putative phosphate binding site [ion binding]; other site
715451003856	GlyGly-CTERM domain; Region: GlyGly_CTERM; TIGR03501
715451003857	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
715451003858	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
715451003859	peroxiredoxin; Region: AhpC; TIGR03137
715451003860	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
715451003861	dimer interface [polypeptide binding]; other site
715451003862	decamer (pentamer of dimers) interface [polypeptide binding]; other site
715451003863	catalytic triad [active]
715451003864	peroxidatic and resolving cysteines [active]
715451003865	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
715451003866	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
715451003867	catalytic residue [active]
715451003868	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
715451003869	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
715451003870	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
715451003871	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
715451003872	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
715451003873	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
715451003874	Strictosidine synthase; Region: Str_synth; pfam03088
715451003875	Cupin domain; Region: Cupin_2; pfam07883
715451003876	hypothetical protein; Provisional; Region: PRK01254
715451003877	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
715451003878	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
715451003879	EVE domain; Region: EVE; cl00728
715451003880	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
715451003881	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451003882	Uncharacterized conserved protein [Function unknown]; Region: COG0398
715451003883	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
715451003884	mercuric reductase; Validated; Region: PRK06370
715451003885	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
715451003886	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
715451003887	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
715451003888	Protein of unknown function, DUF547; Region: DUF547; pfam04784
715451003889	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
715451003890	hypothetical protein; Provisional; Region: PRK11622
715451003891	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135
715451003892	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
715451003893	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136
715451003894	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451003895	Walker A/P-loop; other site
715451003896	ATP binding site [chemical binding]; other site
715451003897	Q-loop/lid; other site
715451003898	ABC transporter signature motif; other site
715451003899	Walker B; other site
715451003900	D-loop; other site
715451003901	H-loop/switch region; other site
715451003902	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
715451003903	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
715451003904	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
715451003905	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
715451003906	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
715451003907	GAF domain; Region: GAF; cl17456
715451003908	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451003909	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451003910	metal binding site [ion binding]; metal-binding site
715451003911	active site
715451003912	I-site; other site
715451003913	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
715451003914	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274
715451003915	putative NAD(P) binding site [chemical binding]; other site
715451003916	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
715451003917	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
715451003918	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451003919	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451003920	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
715451003921	putative effector binding pocket; other site
715451003922	dimerization interface [polypeptide binding]; other site
715451003923	potential frameshift: common BLAST hit: gi|109900102|ref|YP_663357.1| TonB-dependent receptor, plug
715451003924	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
715451003925	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
715451003926	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
715451003927	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
715451003928	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
715451003929	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
715451003930	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451003931	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
715451003932	DNA binding residues [nucleotide binding]
715451003933	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
715451003934	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
715451003935	NAD(P) binding site [chemical binding]; other site
715451003936	catalytic residues [active]
715451003937	choline dehydrogenase; Validated; Region: PRK02106
715451003938	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
715451003939	BCCT family transporter; Region: BCCT; cl00569
715451003940	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451003941	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451003942	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451003943	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
715451003944	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
715451003945	active site
715451003946	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
715451003947	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
715451003948	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
715451003949	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451003950	putative substrate translocation pore; other site
715451003951	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
715451003952	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
715451003953	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
715451003954	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
715451003955	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451003956	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451003957	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
715451003958	HicB family; Region: HicB; pfam05534
715451003959	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
715451003960	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
715451003961	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
715451003962	active site
715451003963	DNA binding site [nucleotide binding]
715451003964	Int/Topo IB signature motif; other site
715451003965	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
715451003966	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
715451003967	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
715451003968	putative active site [active]
715451003969	putative FMN binding site [chemical binding]; other site
715451003970	putative substrate binding site [chemical binding]; other site
715451003971	putative catalytic residue [active]
715451003972	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
715451003973	SmpB-tmRNA interface; other site
715451003974	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
715451003975	putative coenzyme Q binding site [chemical binding]; other site
715451003976	hypothetical protein; Validated; Region: PRK01777
715451003977	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
715451003978	MarR family; Region: MarR; pfam01047
715451003979	BCCT family transporter; Region: BCCT; cl00569
715451003980	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451003981	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
715451003982	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451003983	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
715451003984	binding surface
715451003985	TPR motif; other site
715451003986	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451003987	TPR motif; other site
715451003988	binding surface
715451003989	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451003990	binding surface
715451003991	TPR motif; other site
715451003992	TPR repeat; Region: TPR_11; pfam13414
715451003993	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451003994	binding surface
715451003995	TPR motif; other site
715451003996	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
715451003997	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
715451003998	core domain interface [polypeptide binding]; other site
715451003999	delta subunit interface [polypeptide binding]; other site
715451004000	epsilon subunit interface [polypeptide binding]; other site
715451004001	alternate F1F0 ATPase, F1 subunit alpha; Region: alt_F1F0_F1_al; TIGR03324
715451004002	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
715451004003	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
715451004004	Walker A motif; other site
715451004005	ATP binding site [chemical binding]; other site
715451004006	Walker B motif; other site
715451004007	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
715451004008	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
715451004009	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
715451004010	F0F1 ATP synthase subunit C; Provisional; Region: PRK13468
715451004011	alternate F1F0 ATPase, F0 subunit A; Region: altF1_A; TIGR03306
715451004012	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
715451004013	F1/F0 ATPase, Methanosarcina type, subunit 2; Region: F1F0_chp_2; TIGR03165
715451004014	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
715451004015	F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
715451004016	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
715451004017	gamma subunit interface [polypeptide binding]; other site
715451004018	epsilon subunit interface [polypeptide binding]; other site
715451004019	LBP interface [polypeptide binding]; other site
715451004020	alternate F1F0 ATPase, F1 subunit beta; Region: alt_F1F0_F1_bet; TIGR03305
715451004021	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
715451004022	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
715451004023	alpha subunit interaction interface [polypeptide binding]; other site
715451004024	Walker A motif; other site
715451004025	ATP binding site [chemical binding]; other site
715451004026	Walker B motif; other site
715451004027	inhibitor binding site; inhibition site
715451004028	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
715451004029	Protein of unknown function (DUF1375); Region: DUF1375; pfam07119
715451004030	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451004031	putative substrate translocation pore; other site
715451004032	Major Facilitator Superfamily; Region: MFS_1; pfam07690
715451004033	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
715451004034	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
715451004035	putative active site [active]
715451004036	putative FMN binding site [chemical binding]; other site
715451004037	putative substrate binding site [chemical binding]; other site
715451004038	putative catalytic residue [active]
715451004039	transport protein TonB; Provisional; Region: PRK10819
715451004040	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
715451004041	RNA polymerase sigma factor; Provisional; Region: PRK12513
715451004042	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451004043	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
715451004044	DNA binding residues [nucleotide binding]
715451004045	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
715451004046	active site
715451004047	catalytic motif [active]
715451004048	Zn binding site [ion binding]; other site
715451004049	lipoprotein NlpI; Provisional; Region: PRK11189
715451004050	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451004051	binding surface
715451004052	TPR motif; other site
715451004053	putative sulfate transport protein CysZ; Validated; Region: PRK04949
715451004054	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
715451004055	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
715451004056	Walker A/P-loop; other site
715451004057	ATP binding site [chemical binding]; other site
715451004058	Q-loop/lid; other site
715451004059	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
715451004060	ABC transporter signature motif; other site
715451004061	Walker B; other site
715451004062	D-loop; other site
715451004063	H-loop/switch region; other site
715451004064	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
715451004065	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
715451004066	FtsZ protein binding site [polypeptide binding]; other site
715451004067	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
715451004068	nucleotide binding pocket [chemical binding]; other site
715451004069	K-X-D-G motif; other site
715451004070	catalytic site [active]
715451004071	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
715451004072	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
715451004073	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
715451004074	nucleotide binding pocket [chemical binding]; other site
715451004075	K-X-D-G motif; other site
715451004076	catalytic site [active]
715451004077	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
715451004078	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
715451004079	Dimer interface [polypeptide binding]; other site
715451004080	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
715451004081	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
715451004082	dimerization interface [polypeptide binding]; other site
715451004083	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451004084	dimer interface [polypeptide binding]; other site
715451004085	phosphorylation site [posttranslational modification]
715451004086	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451004087	ATP binding site [chemical binding]; other site
715451004088	Mg2+ binding site [ion binding]; other site
715451004089	G-X-G motif; other site
715451004090	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
715451004091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451004092	active site
715451004093	phosphorylation site [posttranslational modification]
715451004094	intermolecular recognition site; other site
715451004095	dimerization interface [polypeptide binding]; other site
715451004096	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451004097	DNA binding site [nucleotide binding]
715451004098	Protein of unknown function, DUF; Region: DUF411; cl01142
715451004099	Outer membrane efflux protein; Region: OEP; pfam02321
715451004100	Outer membrane efflux protein; Region: OEP; pfam02321
715451004101	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
715451004102	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451004103	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
715451004104	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
715451004105	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
715451004106	CopC domain; Region: CopC; pfam04234
715451004107	Copper resistance protein D; Region: CopD; cl00563
715451004108	SnoaL-like domain; Region: SnoaL_3; pfam13474
715451004109	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
715451004110	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
715451004111	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
715451004112	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
715451004113	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
715451004114	metal-binding site [ion binding]
715451004115	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
715451004116	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
715451004117	Soluble P-type ATPase [General function prediction only]; Region: COG4087
715451004118	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
715451004119	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
715451004120	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
715451004121	amino acid transporter; Region: 2A0306; TIGR00909
715451004122	Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695
715451004123	Domain of unknown function (DUF305); Region: DUF305; cl17794
715451004124	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
715451004125	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
715451004126	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
715451004127	Multicopper oxidase; Region: Cu-oxidase; pfam00394
715451004128	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
715451004129	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
715451004130	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
715451004131	DNA binding residues [nucleotide binding]
715451004132	dimer interface [polypeptide binding]; other site
715451004133	putative metal binding site [ion binding]; other site
715451004134	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
715451004135	Protein of unknown function (DUF3703); Region: DUF3703; pfam12487
715451004136	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
715451004137	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
715451004138	Outer membrane efflux protein; Region: OEP; pfam02321
715451004139	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
715451004140	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
715451004141	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451004142	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
715451004143	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
715451004144	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
715451004145	non-specific DNA binding site [nucleotide binding]; other site
715451004146	salt bridge; other site
715451004147	sequence-specific DNA binding site [nucleotide binding]; other site
715451004148	T5orf172 domain; Region: T5orf172; cl17462
715451004149	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
715451004150	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
715451004151	active site
715451004152	catalytic residues [active]
715451004153	DNA binding site [nucleotide binding]
715451004154	Int/Topo IB signature motif; other site
715451004155	potential frameshift: common BLAST hit: gi|114564575|ref|YP_752089.1| integrase catalytic subunit
715451004156	potential frameshift: common BLAST hit: gi|114564576|ref|YP_752090.1| IstB ATP binding domain-containing protein
715451004157	potential frameshift: common BLAST hit: gi|114564576|ref|YP_752090.1| IstB ATP binding domain-containing protein
715451004158	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
715451004159	active site
715451004160	DNA binding site [nucleotide binding]
715451004161	Int/Topo IB signature motif; other site
715451004162	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
715451004163	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
715451004164	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
715451004165	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
715451004166	Dimer interface [polypeptide binding]; other site
715451004167	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
715451004168	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
715451004169	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
715451004170	Competence protein; Region: Competence; pfam03772
715451004171	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
715451004172	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
715451004173	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
715451004174	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451004175	Walker A/P-loop; other site
715451004176	ATP binding site [chemical binding]; other site
715451004177	Q-loop/lid; other site
715451004178	ABC transporter signature motif; other site
715451004179	Walker B; other site
715451004180	D-loop; other site
715451004181	H-loop/switch region; other site
715451004182	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
715451004183	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
715451004184	Uncharacterized conserved protein [Function unknown]; Region: COG2835
715451004185	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
715451004186	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
715451004187	Ligand binding site; other site
715451004188	oligomer interface; other site
715451004189	C factor cell-cell signaling protein; Provisional; Region: PRK09009
715451004190	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
715451004191	NADP binding site [chemical binding]; other site
715451004192	homodimer interface [polypeptide binding]; other site
715451004193	active site
715451004194	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
715451004195	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
715451004196	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
715451004197	FeS/SAM binding site; other site
715451004198	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
715451004199	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
715451004200	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
715451004201	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
715451004202	putative ATP binding site [chemical binding]; other site
715451004203	putative substrate interface [chemical binding]; other site
715451004204	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
715451004205	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
715451004206	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
715451004207	putative dimer interface [polypeptide binding]; other site
715451004208	N-terminal domain interface [polypeptide binding]; other site
715451004209	putative substrate binding pocket (H-site) [chemical binding]; other site
715451004210	phosphomannomutase CpsG; Provisional; Region: PRK15414
715451004211	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
715451004212	active site
715451004213	substrate binding site [chemical binding]; other site
715451004214	metal binding site [ion binding]; metal-binding site
715451004215	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
715451004216	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
715451004217	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
715451004218	dimer interface [polypeptide binding]; other site
715451004219	active site
715451004220	citrylCoA binding site [chemical binding]; other site
715451004221	NADH binding [chemical binding]; other site
715451004222	cationic pore residues; other site
715451004223	oxalacetate/citrate binding site [chemical binding]; other site
715451004224	coenzyme A binding site [chemical binding]; other site
715451004225	catalytic triad [active]
715451004226	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
715451004227	Iron-sulfur protein interface; other site
715451004228	proximal quinone binding site [chemical binding]; other site
715451004229	SdhD (CybS) interface [polypeptide binding]; other site
715451004230	proximal heme binding site [chemical binding]; other site
715451004231	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
715451004232	SdhC subunit interface [polypeptide binding]; other site
715451004233	proximal heme binding site [chemical binding]; other site
715451004234	cardiolipin binding site; other site
715451004235	Iron-sulfur protein interface; other site
715451004236	proximal quinone binding site [chemical binding]; other site
715451004237	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
715451004238	L-aspartate oxidase; Provisional; Region: PRK06175
715451004239	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
715451004240	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
715451004241	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
715451004242	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
715451004243	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
715451004244	TPP-binding site [chemical binding]; other site
715451004245	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
715451004246	dimer interface [polypeptide binding]; other site
715451004247	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
715451004248	E3 interaction surface; other site
715451004249	lipoyl attachment site [posttranslational modification]; other site
715451004250	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
715451004251	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
715451004252	E3 interaction surface; other site
715451004253	lipoyl attachment site [posttranslational modification]; other site
715451004254	e3 binding domain; Region: E3_binding; pfam02817
715451004255	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
715451004256	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
715451004257	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
715451004258	CoA-ligase; Region: Ligase_CoA; pfam00549
715451004259	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
715451004260	CoA binding domain; Region: CoA_binding; pfam02629
715451004261	CoA-ligase; Region: Ligase_CoA; pfam00549
715451004262	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451004263	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451004264	Transposase; Region: HTH_Tnp_1; pfam01527
715451004265	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
715451004266	putative transposase OrfB; Reviewed; Region: PHA02517
715451004267	HTH-like domain; Region: HTH_21; pfam13276
715451004268	Integrase core domain; Region: rve; pfam00665
715451004269	Integrase core domain; Region: rve_3; pfam13683
715451004270	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451004271	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
715451004272	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
715451004273	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451004274	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451004275	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
715451004276	carbohydrate binding site [chemical binding]; other site
715451004277	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
715451004278	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
715451004279	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
715451004280	Ca binding site [ion binding]; other site
715451004281	active site
715451004282	catalytic site [active]
715451004283	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
715451004284	Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861
715451004285	Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861
715451004286	Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861
715451004287	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
715451004288	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
715451004289	active site
715451004290	nucleophile elbow; other site
715451004291	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
715451004292	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
715451004293	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349
715451004294	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
715451004295	active site
715451004296	catalytic site [active]
715451004297	Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087
715451004298	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340
715451004299	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
715451004300	Ca binding site [ion binding]; other site
715451004301	active site
715451004302	homodimer interface [polypeptide binding]; other site
715451004303	catalytic site [active]
715451004304	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
715451004305	Major Facilitator Superfamily; Region: MFS_1; pfam07690
715451004306	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451004307	putative substrate translocation pore; other site
715451004308	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
715451004309	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
715451004310	active site
715451004311	catalytic site [active]
715451004312	Transcriptional regulators [Transcription]; Region: PurR; COG1609
715451004313	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
715451004314	DNA binding site [nucleotide binding]
715451004315	domain linker motif; other site
715451004316	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
715451004317	putative dimerization interface [polypeptide binding]; other site
715451004318	putative ligand binding site [chemical binding]; other site
715451004319	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
715451004320	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
715451004321	active site
715451004322	HIGH motif; other site
715451004323	nucleotide binding site [chemical binding]; other site
715451004324	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
715451004325	KMSKS motif; other site
715451004326	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
715451004327	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
715451004328	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
715451004329	NAD(P) binding site [chemical binding]; other site
715451004330	active site
715451004331	extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502
715451004332	Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262
715451004333	Penicillin amidase; Region: Penicil_amidase; pfam01804
715451004334	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
715451004335	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
715451004336	active site
715451004337	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
715451004338	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
715451004339	putative inner membrane peptidase; Provisional; Region: PRK11778
715451004340	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
715451004341	tandem repeat interface [polypeptide binding]; other site
715451004342	oligomer interface [polypeptide binding]; other site
715451004343	active site residues [active]
715451004344	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
715451004345	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451004346	Uncharacterized conserved protein [Function unknown]; Region: COG3791
715451004347	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
715451004348	Beta-lactamase; Region: Beta-lactamase; pfam00144
715451004349	Uncharacterized conserved protein [Function unknown]; Region: COG0327
715451004350	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
715451004351	Methyltransferase domain; Region: Methyltransf_23; pfam13489
715451004352	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451004353	S-adenosylmethionine binding site [chemical binding]; other site
715451004354	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
715451004355	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
715451004356	putative ligand binding site [chemical binding]; other site
715451004357	putative NAD binding site [chemical binding]; other site
715451004358	catalytic site [active]
715451004359	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
715451004360	catalytic residues [active]
715451004361	dimer interface [polypeptide binding]; other site
715451004362	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
715451004363	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
715451004364	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451004365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451004366	active site
715451004367	phosphorylation site [posttranslational modification]
715451004368	intermolecular recognition site; other site
715451004369	dimerization interface [polypeptide binding]; other site
715451004370	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
715451004371	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
715451004372	substrate binding pocket [chemical binding]; other site
715451004373	FAD binding site [chemical binding]; other site
715451004374	catalytic base [active]
715451004375	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
715451004376	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
715451004377	substrate binding site [chemical binding]; other site
715451004378	oxyanion hole (OAH) forming residues; other site
715451004379	trimer interface [polypeptide binding]; other site
715451004380	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
715451004381	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
715451004382	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451004383	S-adenosylmethionine binding site [chemical binding]; other site
715451004384	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
715451004385	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
715451004386	active site
715451004387	motif I; other site
715451004388	motif II; other site
715451004389	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
715451004390	Protein of unknown function (DUF1414); Region: DUF1414; cl01175
715451004391	Nucleoid-associated protein [General function prediction only]; Region: COG3081
715451004392	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
715451004393	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
715451004394	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
715451004395	Peptidase family M23; Region: Peptidase_M23; pfam01551
715451004396	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
715451004397	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
715451004398	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
715451004399	Flagellar protein YcgR; Region: YcgR_2; pfam12945
715451004400	PilZ domain; Region: PilZ; pfam07238
715451004401	Protein of unknown function (DUF962); Region: DUF962; cl01879
715451004402	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451004403	Histidine kinase; Region: His_kinase; pfam06580
715451004404	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451004405	ATP binding site [chemical binding]; other site
715451004406	Mg2+ binding site [ion binding]; other site
715451004407	G-X-G motif; other site
715451004408	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
715451004409	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451004410	active site
715451004411	phosphorylation site [posttranslational modification]
715451004412	intermolecular recognition site; other site
715451004413	dimerization interface [polypeptide binding]; other site
715451004414	LytTr DNA-binding domain; Region: LytTR; smart00850
715451004415	6-phosphofructokinase; Provisional; Region: PRK03202
715451004416	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
715451004417	active site
715451004418	ADP/pyrophosphate binding site [chemical binding]; other site
715451004419	dimerization interface [polypeptide binding]; other site
715451004420	allosteric effector site; other site
715451004421	fructose-1,6-bisphosphate binding site; other site
715451004422	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451004423	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451004424	active site
715451004425	phosphorylation site [posttranslational modification]
715451004426	intermolecular recognition site; other site
715451004427	dimerization interface [polypeptide binding]; other site
715451004428	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451004429	binding surface
715451004430	TPR motif; other site
715451004431	Tetratricopeptide repeat; Region: TPR_16; pfam13432
715451004432	Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993
715451004433	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
715451004434	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
715451004435	active site residue [active]
715451004436	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
715451004437	EF-hand domain pair; Region: EF_hand_5; pfam13499
715451004438	Ca2+ binding site [ion binding]; other site
715451004439	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
715451004440	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
715451004441	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
715451004442	probable active site [active]
715451004443	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
715451004444	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
715451004445	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
715451004446	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
715451004447	ATP binding site [chemical binding]; other site
715451004448	Mg++ binding site [ion binding]; other site
715451004449	motif III; other site
715451004450	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451004451	nucleotide binding region [chemical binding]; other site
715451004452	ATP-binding site [chemical binding]; other site
715451004453	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
715451004454	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
715451004455	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451004456	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451004457	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
715451004458	putative dimerization interface [polypeptide binding]; other site
715451004459	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451004460	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451004461	ATP binding site [chemical binding]; other site
715451004462	Mg2+ binding site [ion binding]; other site
715451004463	G-X-G motif; other site
715451004464	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
715451004465	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451004466	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
715451004467	substrate binding site [chemical binding]; other site
715451004468	dimerization interface [polypeptide binding]; other site
715451004469	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
715451004470	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
715451004471	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
715451004472	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
715451004473	putative active site [active]
715451004474	putative CoA binding site [chemical binding]; other site
715451004475	nudix motif; other site
715451004476	metal binding site [ion binding]; metal-binding site
715451004477	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
715451004478	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
715451004479	chorismate binding enzyme; Region: Chorismate_bind; cl10555
715451004480	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
715451004481	Fumarase C-terminus; Region: Fumerase_C; pfam05683
715451004482	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
715451004483	RmuC family; Region: RmuC; pfam02646
715451004484	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
715451004485	Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852
715451004486	active site
715451004487	catalytic triad [active]
715451004488	PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120
715451004489	PA/protease or protease-like domain interface [polypeptide binding]; other site
715451004490	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
715451004491	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
715451004492	catalytic residues [active]
715451004493	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
715451004494	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
715451004495	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
715451004496	tetramer interface [polypeptide binding]; other site
715451004497	TPP-binding site [chemical binding]; other site
715451004498	heterodimer interface [polypeptide binding]; other site
715451004499	phosphorylation loop region [posttranslational modification]
715451004500	3-methyl-2-oxobutanate dehydrogenase; Provisional; Region: PTZ00182
715451004501	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
715451004502	alpha subunit interface [polypeptide binding]; other site
715451004503	TPP binding site [chemical binding]; other site
715451004504	heterodimer interface [polypeptide binding]; other site
715451004505	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
715451004506	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
715451004507	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
715451004508	E3 interaction surface; other site
715451004509	lipoyl attachment site [posttranslational modification]; other site
715451004510	e3 binding domain; Region: E3_binding; pfam02817
715451004511	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
715451004512	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
715451004513	Catalytic domain of Protein Kinases; Region: PKc; cd00180
715451004514	active site
715451004515	ATP binding site [chemical binding]; other site
715451004516	substrate binding site [chemical binding]; other site
715451004517	activation loop (A-loop); other site
715451004518	acyl-CoA thioesterase II; Provisional; Region: PRK10526
715451004519	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
715451004520	active site
715451004521	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
715451004522	catalytic triad [active]
715451004523	dimer interface [polypeptide binding]; other site
715451004524	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
715451004525	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
715451004526	trimer interface [polypeptide binding]; other site
715451004527	putative metal binding site [ion binding]; other site
715451004528	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
715451004529	homodimer interface [polypeptide binding]; other site
715451004530	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451004531	catalytic residue [active]
715451004532	Uncharacterized conserved protein [Function unknown]; Region: COG2968
715451004533	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
715451004534	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
715451004535	GAF domain; Region: GAF_2; pfam13185
715451004536	ProP expression regulator; Provisional; Region: PRK04950
715451004537	ProQ/FINO family; Region: ProQ; pfam04352
715451004538	carboxy-terminal protease; Provisional; Region: PRK11186
715451004539	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
715451004540	protein binding site [polypeptide binding]; other site
715451004541	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
715451004542	Catalytic dyad [active]
715451004543	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
715451004544	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
715451004545	Na2 binding site [ion binding]; other site
715451004546	putative substrate binding site 1 [chemical binding]; other site
715451004547	Na binding site 1 [ion binding]; other site
715451004548	putative substrate binding site 2 [chemical binding]; other site
715451004549	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
715451004550	aminopeptidase N; Provisional; Region: pepN; PRK14015
715451004551	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
715451004552	Zn binding site [ion binding]; other site
715451004553	Protein of unknown function (DUF2835); Region: DUF2835; pfam11197
715451004554	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
715451004555	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
715451004556	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
715451004557	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
715451004558	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
715451004559	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
715451004560	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
715451004561	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
715451004562	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
715451004563	quinone interaction residues [chemical binding]; other site
715451004564	active site
715451004565	catalytic residues [active]
715451004566	FMN binding site [chemical binding]; other site
715451004567	substrate binding site [chemical binding]; other site
715451004568	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
715451004569	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
715451004570	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
715451004571	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
715451004572	putative RNA binding site [nucleotide binding]; other site
715451004573	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451004574	S-adenosylmethionine binding site [chemical binding]; other site
715451004575	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
715451004576	ABC transporter ATPase component; Reviewed; Region: PRK11147
715451004577	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
715451004578	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
715451004579	ABC transporter; Region: ABC_tran_2; pfam12848
715451004580	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
715451004581	Protein of unknown function (DUF3466); Region: DUF3466; pfam11949
715451004582	Ribosome modulation factor; Region: RMF; pfam04957
715451004583	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
715451004584	active site 1 [active]
715451004585	dimer interface [polypeptide binding]; other site
715451004586	active site 2 [active]
715451004587	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
715451004588	DNA photolyase; Region: DNA_photolyase; pfam00875
715451004589	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
715451004590	DNA photolyase; Region: DNA_photolyase; pfam00875
715451004591	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
715451004592	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
715451004593	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
715451004594	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
715451004595	Predicted membrane protein [Function unknown]; Region: COG4325
715451004596	Helix-turn-helix domain; Region: HTH_38; pfam13936
715451004597	Phage replication protein CRI; Region: Phage_CRI; pfam05144
715451004598	Phage X family; Region: Phage_X; cl11585
715451004599	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
715451004600	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
715451004601	active site
715451004602	DNA binding site [nucleotide binding]
715451004603	Int/Topo IB signature motif; other site
715451004604	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
715451004605	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
715451004606	Ligand Binding Site [chemical binding]; other site
715451004607	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
715451004608	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
715451004609	active site
715451004610	FMN binding site [chemical binding]; other site
715451004611	substrate binding site [chemical binding]; other site
715451004612	3Fe-4S cluster binding site [ion binding]; other site
715451004613	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
715451004614	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
715451004615	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
715451004616	TrkA-N domain; Region: TrkA_N; pfam02254
715451004617	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
715451004618	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
715451004619	heme binding site [chemical binding]; other site
715451004620	ferroxidase pore; other site
715451004621	ferroxidase diiron center [ion binding]; other site
715451004622	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
715451004623	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
715451004624	heme binding site [chemical binding]; other site
715451004625	ferroxidase pore; other site
715451004626	ferroxidase diiron center [ion binding]; other site
715451004627	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
715451004628	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
715451004629	Low-spin heme binding site [chemical binding]; other site
715451004630	Putative water exit pathway; other site
715451004631	Binuclear center (active site) [active]
715451004632	Putative proton exit pathway; other site
715451004633	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
715451004634	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
715451004635	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
715451004636	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
715451004637	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
715451004638	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
715451004639	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
715451004640	FixH; Region: FixH; pfam05751
715451004641	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
715451004642	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
715451004643	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
715451004644	metal-binding site [ion binding]
715451004645	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
715451004646	Soluble P-type ATPase [General function prediction only]; Region: COG4087
715451004647	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
715451004648	Family description; Region: DsbD_2; pfam13386
715451004649	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
715451004650	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
715451004651	ligand binding site [chemical binding]; other site
715451004652	flexible hinge region; other site
715451004653	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
715451004654	putative switch regulator; other site
715451004655	non-specific DNA interactions [nucleotide binding]; other site
715451004656	DNA binding site [nucleotide binding]
715451004657	sequence specific DNA binding site [nucleotide binding]; other site
715451004658	putative cAMP binding site [chemical binding]; other site
715451004659	universal stress protein UspE; Provisional; Region: PRK11175
715451004660	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
715451004661	Ligand Binding Site [chemical binding]; other site
715451004662	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
715451004663	Ligand Binding Site [chemical binding]; other site
715451004664	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
715451004665	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
715451004666	Ligand Binding Site [chemical binding]; other site
715451004667	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
715451004668	nucleophile elbow; other site
715451004669	Protein of unknown function (DUF2987); Region: DUF2987; pfam11205
715451004670	Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992
715451004671	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
715451004672	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
715451004673	NAD-dependent deacetylase; Provisional; Region: PRK00481
715451004674	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
715451004675	NAD+ binding site [chemical binding]; other site
715451004676	substrate binding site [chemical binding]; other site
715451004677	Zn binding site [ion binding]; other site
715451004678	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
715451004679	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
715451004680	active site residue [active]
715451004681	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
715451004682	active site residue [active]
715451004683	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
715451004684	dimer interface [polypeptide binding]; other site
715451004685	catalytic triad [active]
715451004686	peroxidatic and resolving cysteines [active]
715451004687	Uncharacterized conserved protein [Function unknown]; Region: COG3148
715451004688	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
715451004689	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
715451004690	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
715451004691	active site
715451004692	catalytic site [active]
715451004693	putative DNA binding site [nucleotide binding]; other site
715451004694	GIY-YIG motif/motif A; other site
715451004695	metal binding site [ion binding]; metal-binding site
715451004696	UvrB/uvrC motif; Region: UVR; pfam02151
715451004697	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
715451004698	Helix-hairpin-helix motif; Region: HHH; pfam00633
715451004699	response regulator; Provisional; Region: PRK09483
715451004700	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451004701	active site
715451004702	phosphorylation site [posttranslational modification]
715451004703	intermolecular recognition site; other site
715451004704	dimerization interface [polypeptide binding]; other site
715451004705	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
715451004706	DNA binding residues [nucleotide binding]
715451004707	dimerization interface [polypeptide binding]; other site
715451004708	Pirin-related protein [General function prediction only]; Region: COG1741
715451004709	Pirin; Region: Pirin; pfam02678
715451004710	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
715451004711	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
715451004712	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451004713	homodimer interface [polypeptide binding]; other site
715451004714	catalytic residue [active]
715451004715	5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344
715451004716	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
715451004717	Methyltransferase domain; Region: Methyltransf_31; pfam13847
715451004718	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451004719	S-adenosylmethionine binding site [chemical binding]; other site
715451004720	Protein of unknown function (DUF3360); Region: DUF3360; pfam11840
715451004721	Transcriptional regulators [Transcription]; Region: MarR; COG1846
715451004722	MarR family; Region: MarR_2; pfam12802
715451004723	NADH(P)-binding; Region: NAD_binding_10; pfam13460
715451004724	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
715451004725	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451004726	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451004727	dimer interface [polypeptide binding]; other site
715451004728	phosphorylation site [posttranslational modification]
715451004729	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
715451004730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451004731	active site
715451004732	phosphorylation site [posttranslational modification]
715451004733	intermolecular recognition site; other site
715451004734	dimerization interface [polypeptide binding]; other site
715451004735	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451004736	DNA binding site [nucleotide binding]
715451004737	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
715451004738	active site triad [active]
715451004739	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
715451004740	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
715451004741	potential catalytic triad [active]
715451004742	conserved cys residue [active]
715451004743	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
715451004744	catalytic motif [active]
715451004745	Catalytic residue [active]
715451004746	Aspartyl protease; Region: Asp_protease_2; pfam13650
715451004747	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
715451004748	protein binding site [polypeptide binding]; other site
715451004749	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
715451004750	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
715451004751	Beta-lactamase; Region: Beta-lactamase; pfam00144
715451004752	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
715451004753	YccA-like proteins; Region: YccA_like; cd10433
715451004754	sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012
715451004755	DsrE/DsrF-like family; Region: DrsE; cl00672
715451004756	DsrC like protein; Region: DsrC; pfam04358
715451004757	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
715451004758	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
715451004759	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
715451004760	active site
715451004761	motif I; other site
715451004762	motif II; other site
715451004763	seryl-tRNA synthetase; Provisional; Region: PRK05431
715451004764	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
715451004765	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
715451004766	dimer interface [polypeptide binding]; other site
715451004767	active site
715451004768	motif 1; other site
715451004769	motif 2; other site
715451004770	motif 3; other site
715451004771	CrcB-like protein; Region: CRCB; cl09114
715451004772	recombination factor protein RarA; Reviewed; Region: PRK13342
715451004773	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451004774	Walker A motif; other site
715451004775	ATP binding site [chemical binding]; other site
715451004776	Walker B motif; other site
715451004777	arginine finger; other site
715451004778	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
715451004779	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
715451004780	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
715451004781	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
715451004782	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
715451004783	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
715451004784	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
715451004785	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
715451004786	putative DNA binding site [nucleotide binding]; other site
715451004787	putative Zn2+ binding site [ion binding]; other site
715451004788	AsnC family; Region: AsnC_trans_reg; pfam01037
715451004789	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
715451004790	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
715451004791	hexamer interface [polypeptide binding]; other site
715451004792	ligand binding site [chemical binding]; other site
715451004793	putative active site [active]
715451004794	NAD(P) binding site [chemical binding]; other site
715451004795	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
715451004796	active site
715451004797	dimer interface [polypeptide binding]; other site
715451004798	tetratricopeptide repeat protein; Provisional; Region: PRK11788
715451004799	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451004800	binding surface
715451004801	TPR motif; other site
715451004802	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451004803	binding surface
715451004804	TPR motif; other site
715451004805	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
715451004806	PilZ domain; Region: PilZ; pfam07238
715451004807	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
715451004808	IHF dimer interface [polypeptide binding]; other site
715451004809	IHF - DNA interface [nucleotide binding]; other site
715451004810	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
715451004811	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
715451004812	RNA binding site [nucleotide binding]; other site
715451004813	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
715451004814	RNA binding site [nucleotide binding]; other site
715451004815	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
715451004816	RNA binding site [nucleotide binding]; other site
715451004817	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
715451004818	RNA binding site [nucleotide binding]; other site
715451004819	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
715451004820	RNA binding site [nucleotide binding]; other site
715451004821	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
715451004822	RNA binding site [nucleotide binding]; other site
715451004823	cytidylate kinase; Provisional; Region: cmk; PRK00023
715451004824	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
715451004825	CMP-binding site; other site
715451004826	The sites determining sugar specificity; other site
715451004827	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
715451004828	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
715451004829	hinge; other site
715451004830	active site
715451004831	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
715451004832	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
715451004833	homodimer interface [polypeptide binding]; other site
715451004834	substrate-cofactor binding pocket; other site
715451004835	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451004836	catalytic residue [active]
715451004837	DNA gyrase subunit A; Validated; Region: PRK05560
715451004838	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
715451004839	CAP-like domain; other site
715451004840	active site
715451004841	primary dimer interface [polypeptide binding]; other site
715451004842	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
715451004843	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
715451004844	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
715451004845	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
715451004846	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
715451004847	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
715451004848	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
715451004849	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451004850	S-adenosylmethionine binding site [chemical binding]; other site
715451004851	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
715451004852	ATP cone domain; Region: ATP-cone; pfam03477
715451004853	Class I ribonucleotide reductase; Region: RNR_I; cd01679
715451004854	active site
715451004855	dimer interface [polypeptide binding]; other site
715451004856	catalytic residues [active]
715451004857	effector binding site; other site
715451004858	R2 peptide binding site; other site
715451004859	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
715451004860	dimer interface [polypeptide binding]; other site
715451004861	putative radical transfer pathway; other site
715451004862	diiron center [ion binding]; other site
715451004863	tyrosyl radical; other site
715451004864	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
715451004865	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
715451004866	catalytic loop [active]
715451004867	iron binding site [ion binding]; other site
715451004868	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451004869	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451004870	dimer interface [polypeptide binding]; other site
715451004871	phosphorylation site [posttranslational modification]
715451004872	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451004873	ATP binding site [chemical binding]; other site
715451004874	Mg2+ binding site [ion binding]; other site
715451004875	G-X-G motif; other site
715451004876	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
715451004877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451004878	active site
715451004879	phosphorylation site [posttranslational modification]
715451004880	intermolecular recognition site; other site
715451004881	dimerization interface [polypeptide binding]; other site
715451004882	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451004883	DNA binding site [nucleotide binding]
715451004884	Spondin_N; Region: Spond_N; pfam06468
715451004885	Spondin_N; Region: Spond_N; pfam06468
715451004886	YHYH protein; Region: YHYH; pfam14240
715451004887	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
715451004888	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
715451004889	Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
715451004890	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
715451004891	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
715451004892	Beta-lactamase; Region: Beta-lactamase; pfam00144
715451004893	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451004894	binding surface
715451004895	TPR repeat; Region: TPR_11; pfam13414
715451004896	TPR motif; other site
715451004897	Transposase; Region: DEDD_Tnp_IS110; pfam01548
715451004898	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
715451004899	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
715451004900	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
715451004901	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
715451004902	NAD(P) binding site [chemical binding]; other site
715451004903	active site
715451004904	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
715451004905	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
715451004906	DNA binding residues [nucleotide binding]
715451004907	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
715451004908	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
715451004909	putative active site [active]
715451004910	putative NTP binding site [chemical binding]; other site
715451004911	putative nucleic acid binding site [nucleotide binding]; other site
715451004912	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
715451004913	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451004914	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451004915	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
715451004916	dimerization interface [polypeptide binding]; other site
715451004917	putative effector binding pocket; other site
715451004918	CAAX protease self-immunity; Region: Abi; pfam02517
715451004919	potential frameshift: common BLAST hit: gi|114564576|ref|YP_752090.1| IstB ATP binding domain-containing protein
715451004920	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
715451004921	Integrase core domain; Region: rve; pfam00665
715451004922	TIR domain; Region: TIR_2; pfam13676
715451004923	Protein of unknown function (DUF2806); Region: DUF2806; pfam10987
715451004924	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
715451004925	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
715451004926	active site
715451004927	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
715451004928	Ligand Binding Site [chemical binding]; other site
715451004929	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
715451004930	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
715451004931	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
715451004932	active site
715451004933	conformational flexibility of ligand binding pocket; other site
715451004934	ADP-ribosylating toxin turn-turn motif; other site
715451004935	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
715451004936	Cytochrome c; Region: Cytochrom_C; cl11414
715451004937	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
715451004938	Cytochrome c; Region: Cytochrom_C; pfam00034
715451004939	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
715451004940	active site residue [active]
715451004941	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
715451004942	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
715451004943	substrate binding pocket (H-site) [chemical binding]; other site
715451004944	N-terminal domain interface [polypeptide binding]; other site
715451004945	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
715451004946	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
715451004947	Walker A/P-loop; other site
715451004948	ATP binding site [chemical binding]; other site
715451004949	Q-loop/lid; other site
715451004950	ABC transporter signature motif; other site
715451004951	Walker B; other site
715451004952	D-loop; other site
715451004953	H-loop/switch region; other site
715451004954	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
715451004955	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
715451004956	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
715451004957	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
715451004958	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
715451004959	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451004960	N-terminal plug; other site
715451004961	ligand-binding site [chemical binding]; other site
715451004962	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
715451004963	EamA-like transporter family; Region: EamA; pfam00892
715451004964	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
715451004965	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
715451004966	ATP binding site [chemical binding]; other site
715451004967	active site
715451004968	substrate binding site [chemical binding]; other site
715451004969	lipoprotein; Provisional; Region: PRK11679
715451004970	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
715451004971	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
715451004972	dihydrodipicolinate synthase; Region: dapA; TIGR00674
715451004973	dimer interface [polypeptide binding]; other site
715451004974	active site
715451004975	catalytic residue [active]
715451004976	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
715451004977	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
715451004978	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
715451004979	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
715451004980	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
715451004981	catalytic triad [active]
715451004982	Domain of unknown function DUF20; Region: UPF0118; pfam01594
715451004983	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
715451004984	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
715451004985	Peptidase family M48; Region: Peptidase_M48; cl12018
715451004986	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
715451004987	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
715451004988	catalytic residues [active]
715451004989	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
715451004990	ArsC family; Region: ArsC; pfam03960
715451004991	catalytic residues [active]
715451004992	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
715451004993	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
715451004994	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
715451004995	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
715451004996	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
715451004997	Walker A motif; other site
715451004998	ATP binding site [chemical binding]; other site
715451004999	Walker B motif; other site
715451005000	arginine finger; other site
715451005001	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
715451005002	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
715451005003	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
715451005004	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
715451005005	dimerization interface [polypeptide binding]; other site
715451005006	putative ATP binding site [chemical binding]; other site
715451005007	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
715451005008	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
715451005009	active site
715451005010	substrate binding site [chemical binding]; other site
715451005011	cosubstrate binding site; other site
715451005012	catalytic site [active]
715451005013	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
715451005014	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
715451005015	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
715451005016	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
715451005017	active site
715451005018	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
715451005019	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
715451005020	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
715451005021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451005022	active site
715451005023	phosphorylation site [posttranslational modification]
715451005024	intermolecular recognition site; other site
715451005025	dimerization interface [polypeptide binding]; other site
715451005026	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
715451005027	DNA binding residues [nucleotide binding]
715451005028	dimerization interface [polypeptide binding]; other site
715451005029	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451005030	S-adenosylmethionine binding site [chemical binding]; other site
715451005031	Methyltransferase domain; Region: Methyltransf_31; pfam13847
715451005032	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451005033	S-adenosylmethionine binding site [chemical binding]; other site
715451005034	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
715451005035	active site
715451005036	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192
715451005037	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
715451005038	active site
715451005039	motif I; other site
715451005040	motif II; other site
715451005041	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
715451005042	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
715451005043	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
715451005044	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
715451005045	active site
715451005046	homodimer interface [polypeptide binding]; other site
715451005047	catalytic site [active]
715451005048	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
715451005049	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
715451005050	dimer interface [polypeptide binding]; other site
715451005051	putative functional site; other site
715451005052	putative MPT binding site; other site
715451005053	multidrug efflux protein; Reviewed; Region: PRK01766
715451005054	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
715451005055	cation binding site [ion binding]; other site
715451005056	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
715451005057	Ligand binding site; other site
715451005058	metal-binding site
715451005059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
715451005060	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
715451005061	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451005062	Walker A motif; other site
715451005063	ATP binding site [chemical binding]; other site
715451005064	Walker B motif; other site
715451005065	arginine finger; other site
715451005066	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
715451005067	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
715451005068	dimer interface [polypeptide binding]; other site
715451005069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451005070	catalytic residue [active]
715451005071	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
715451005072	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
715451005073	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
715451005074	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
715451005075	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
715451005076	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
715451005077	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
715451005078	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
715451005079	enoyl-CoA hydratase; Provisional; Region: PRK06688
715451005080	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
715451005081	substrate binding site [chemical binding]; other site
715451005082	oxyanion hole (OAH) forming residues; other site
715451005083	trimer interface [polypeptide binding]; other site
715451005084	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
715451005085	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
715451005086	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
715451005087	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
715451005088	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
715451005089	hypothetical protein; Provisional; Region: PRK05939
715451005090	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
715451005091	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
715451005092	catalytic residue [active]
715451005093	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
715451005094	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
715451005095	putative acyl-acceptor binding pocket; other site
715451005096	NRDE protein; Region: NRDE; cl01315
715451005097	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
715451005098	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
715451005099	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451005100	homodimer interface [polypeptide binding]; other site
715451005101	catalytic residue [active]
715451005102	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
715451005103	short chain dehydrogenase; Provisional; Region: PRK07035
715451005104	classical (c) SDRs; Region: SDR_c; cd05233
715451005105	NAD(P) binding site [chemical binding]; other site
715451005106	active site
715451005107	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
715451005108	classical (c) SDRs; Region: SDR_c; cd05233
715451005109	NAD(P) binding site [chemical binding]; other site
715451005110	active site
715451005111	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
715451005112	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
715451005113	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
715451005114	active site
715451005115	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
715451005116	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
715451005117	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
715451005118	conserved cys residue [active]
715451005119	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
715451005120	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
715451005121	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451005122	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451005123	N-terminal plug; other site
715451005124	ligand-binding site [chemical binding]; other site
715451005125	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
715451005126	Protein export membrane protein; Region: SecD_SecF; cl14618
715451005127	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
715451005128	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451005129	N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184
715451005130	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
715451005131	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
715451005132	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
715451005133	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
715451005134	Ligand binding site [chemical binding]; other site
715451005135	Electron transfer flavoprotein domain; Region: ETF; pfam01012
715451005136	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
715451005137	hydroxyglutarate oxidase; Provisional; Region: PRK11728
715451005138	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
715451005139	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
715451005140	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
715451005141	acyl-CoA esterase; Provisional; Region: PRK10673
715451005142	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
715451005143	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
715451005144	flavodoxin FldA; Validated; Region: PRK09267
715451005145	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
715451005146	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
715451005147	dimerization interface [polypeptide binding]; other site
715451005148	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
715451005149	dimer interface [polypeptide binding]; other site
715451005150	putative CheW interface [polypeptide binding]; other site
715451005151	ferric uptake regulator; Provisional; Region: fur; PRK09462
715451005152	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
715451005153	metal binding site 2 [ion binding]; metal-binding site
715451005154	putative DNA binding helix; other site
715451005155	metal binding site 1 [ion binding]; metal-binding site
715451005156	dimer interface [polypeptide binding]; other site
715451005157	structural Zn2+ binding site [ion binding]; other site
715451005158	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
715451005159	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451005160	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451005161	Trehalase; Region: Trehalase; cl17346
715451005162	fructuronate transporter; Provisional; Region: PRK10034; cl15264
715451005163	GntP family permease; Region: GntP_permease; pfam02447
715451005164	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
715451005165	AAA domain; Region: AAA_33; pfam13671
715451005166	ATP-binding site [chemical binding]; other site
715451005167	Gluconate-6-phosphate binding site [chemical binding]; other site
715451005168	Transcriptional regulators [Transcription]; Region: PurR; COG1609
715451005169	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
715451005170	DNA binding site [nucleotide binding]
715451005171	domain linker motif; other site
715451005172	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
715451005173	putative dimerization interface [polypeptide binding]; other site
715451005174	putative ligand binding site [chemical binding]; other site
715451005175	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
715451005176	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
715451005177	homodimer interface [polypeptide binding]; other site
715451005178	substrate-cofactor binding pocket; other site
715451005179	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451005180	catalytic residue [active]
715451005181	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
715451005182	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
715451005183	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
715451005184	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
715451005185	putative active site [active]
715451005186	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
715451005187	S1 domain; Region: S1_2; pfam13509
715451005188	OsmC-like protein; Region: OsmC; cl00767
715451005189	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
715451005190	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
715451005191	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451005192	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
715451005193	Protein export membrane protein; Region: SecD_SecF; cl14618
715451005194	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
715451005195	Protein of unknown function (DUF3718); Region: DUF3718; pfam12514
715451005196	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
715451005197	aminotransferase AlaT; Validated; Region: PRK09265
715451005198	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
715451005199	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451005200	homodimer interface [polypeptide binding]; other site
715451005201	catalytic residue [active]
715451005202	5'-nucleotidase; Provisional; Region: PRK03826
715451005203	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
715451005204	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
715451005205	NAD(P) binding site [chemical binding]; other site
715451005206	active site
715451005207	Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919
715451005208	putative active site [active]
715451005209	redox center [active]
715451005210	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
715451005211	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
715451005212	Cytochrome c; Region: Cytochrom_C; pfam00034
715451005213	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
715451005214	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
715451005215	D-pathway; other site
715451005216	Putative ubiquinol binding site [chemical binding]; other site
715451005217	Low-spin heme (heme b) binding site [chemical binding]; other site
715451005218	Putative water exit pathway; other site
715451005219	Binuclear center (heme o3/CuB) [ion binding]; other site
715451005220	K-pathway; other site
715451005221	Putative proton exit pathway; other site
715451005222	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
715451005223	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
715451005224	Subunit I/III interface [polypeptide binding]; other site
715451005225	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
715451005226	Cytochrome c; Region: Cytochrom_C; cl11414
715451005227	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
715451005228	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
715451005229	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
715451005230	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
715451005231	Zn2+ binding site [ion binding]; other site
715451005232	Mg2+ binding site [ion binding]; other site
715451005233	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
715451005234	RDD family; Region: RDD; pfam06271
715451005235	TMAO/DMSO reductase; Reviewed; Region: PRK05363
715451005236	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
715451005237	Moco binding site; other site
715451005238	metal coordination site [ion binding]; other site
715451005239	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
715451005240	Predicted membrane protein [Function unknown]; Region: COG1238
715451005241	hypothetical protein; Provisional; Region: PRK01617
715451005242	SEC-C motif; Region: SEC-C; pfam02810
715451005243	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
715451005244	methionine synthase; Provisional; Region: PRK01207
715451005245	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
715451005246	substrate binding site [chemical binding]; other site
715451005247	THF binding site; other site
715451005248	zinc-binding site [ion binding]; other site
715451005249	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
715451005250	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
715451005251	Uncharacterized conserved protein [Function unknown]; Region: COG1432
715451005252	LabA_like proteins; Region: LabA; cd10911
715451005253	putative metal binding site [ion binding]; other site
715451005254	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
715451005255	Tic20-like protein; Region: Tic20; pfam09685
715451005256	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
715451005257	Coenzyme A binding pocket [chemical binding]; other site
715451005258	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
715451005259	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
715451005260	Walker A/P-loop; other site
715451005261	ATP binding site [chemical binding]; other site
715451005262	Q-loop/lid; other site
715451005263	ABC transporter signature motif; other site
715451005264	Walker B; other site
715451005265	D-loop; other site
715451005266	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451005267	Walker A/P-loop; other site
715451005268	ATP binding site [chemical binding]; other site
715451005269	Q-loop/lid; other site
715451005270	ABC transporter signature motif; other site
715451005271	Walker B; other site
715451005272	D-loop; other site
715451005273	H-loop/switch region; other site
715451005274	Protein of unknown function (DUF1244); Region: DUF1244; cl01385
715451005275	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
715451005276	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
715451005277	RNase E interface [polypeptide binding]; other site
715451005278	trimer interface [polypeptide binding]; other site
715451005279	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
715451005280	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
715451005281	RNase E interface [polypeptide binding]; other site
715451005282	trimer interface [polypeptide binding]; other site
715451005283	active site
715451005284	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
715451005285	putative nucleic acid binding region [nucleotide binding]; other site
715451005286	G-X-X-G motif; other site
715451005287	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
715451005288	RNA binding site [nucleotide binding]; other site
715451005289	domain interface; other site
715451005290	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
715451005291	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
715451005292	active site
715451005293	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
715451005294	Mechanosensitive ion channel; Region: MS_channel; pfam00924
715451005295	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
715451005296	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
715451005297	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
715451005298	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
715451005299	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
715451005300	putative catalytic cysteine [active]
715451005301	gamma-glutamyl kinase; Provisional; Region: PRK13402
715451005302	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
715451005303	nucleotide binding site [chemical binding]; other site
715451005304	homotetrameric interface [polypeptide binding]; other site
715451005305	putative phosphate binding site [ion binding]; other site
715451005306	putative allosteric binding site; other site
715451005307	PUA domain; Region: PUA; cl00607
715451005308	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
715451005309	Na binding site [ion binding]; other site
715451005310	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
715451005311	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
715451005312	active site
715451005313	DNA binding site [nucleotide binding]
715451005314	Int/Topo IB signature motif; other site
715451005315	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
715451005316	hypothetical protein; Provisional; Region: PRK12361
715451005317	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
715451005318	active site
715451005319	catalytic residues [active]
715451005320	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
715451005321	Hemerythrin-like domain; Region: Hr-like; cd12108
715451005322	Fe binding site [ion binding]; other site
715451005323	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
715451005324	HAMP domain; Region: HAMP; pfam00672
715451005325	dimerization interface [polypeptide binding]; other site
715451005326	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451005327	metal binding site [ion binding]; metal-binding site
715451005328	active site
715451005329	I-site; other site
715451005330	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451005331	Preprotein translocase SecG subunit; Region: SecG; pfam03840
715451005332	triosephosphate isomerase; Provisional; Region: PRK14567
715451005333	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
715451005334	substrate binding site [chemical binding]; other site
715451005335	dimer interface [polypeptide binding]; other site
715451005336	catalytic triad [active]
715451005337	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
715451005338	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
715451005339	active site
715451005340	substrate binding site [chemical binding]; other site
715451005341	metal binding site [ion binding]; metal-binding site
715451005342	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
715451005343	dihydropteroate synthase; Region: DHPS; TIGR01496
715451005344	substrate binding pocket [chemical binding]; other site
715451005345	dimer interface [polypeptide binding]; other site
715451005346	inhibitor binding site; inhibition site
715451005347	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
715451005348	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451005349	Walker A motif; other site
715451005350	ATP binding site [chemical binding]; other site
715451005351	Walker B motif; other site
715451005352	arginine finger; other site
715451005353	Peptidase family M41; Region: Peptidase_M41; pfam01434
715451005354	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
715451005355	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451005356	S-adenosylmethionine binding site [chemical binding]; other site
715451005357	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
715451005358	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
715451005359	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
715451005360	NAD binding site [chemical binding]; other site
715451005361	homodimer interface [polypeptide binding]; other site
715451005362	homotetramer interface [polypeptide binding]; other site
715451005363	active site
715451005364	AAA domain; Region: AAA_32; pfam13654
715451005365	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
715451005366	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
715451005367	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
715451005368	HIGH motif; other site
715451005369	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
715451005370	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
715451005371	active site
715451005372	KMSKS motif; other site
715451005373	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
715451005374	tRNA binding surface [nucleotide binding]; other site
715451005375	Lipopolysaccharide-assembly; Region: LptE; cl01125
715451005376	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
715451005377	DNA polymerase III, delta subunit; Region: holA; TIGR01128
715451005378	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
715451005379	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
715451005380	active site
715451005381	(T/H)XGH motif; other site
715451005382	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
715451005383	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
715451005384	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
715451005385	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
715451005386	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
715451005387	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
715451005388	rare lipoprotein A; Provisional; Region: PRK10672
715451005389	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
715451005390	Sporulation related domain; Region: SPOR; pfam05036
715451005391	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
715451005392	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
715451005393	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
715451005394	hypothetical protein; Provisional; Region: PRK04998
715451005395	lipoate-protein ligase B; Provisional; Region: PRK14342
715451005396	lipoyl synthase; Provisional; Region: PRK05481
715451005397	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
715451005398	FeS/SAM binding site; other site
715451005399	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
715451005400	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
715451005401	active site
715451005402	homodimer interface [polypeptide binding]; other site
715451005403	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
715451005404	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
715451005405	putative FMN binding site [chemical binding]; other site
715451005406	DoxX; Region: DoxX; pfam07681
715451005407	protease 4; Provisional; Region: PRK10949
715451005408	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
715451005409	tandem repeat interface [polypeptide binding]; other site
715451005410	oligomer interface [polypeptide binding]; other site
715451005411	active site residues [active]
715451005412	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
715451005413	tandem repeat interface [polypeptide binding]; other site
715451005414	oligomer interface [polypeptide binding]; other site
715451005415	active site residues [active]
715451005416	SprT homologues; Region: SprT; cl01182
715451005417	Protein of unknown function, DUF412; Region: DUF412; pfam04217
715451005418	thioredoxin reductase; Provisional; Region: PRK10262
715451005419	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
715451005420	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
715451005421	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
715451005422	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
715451005423	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
715451005424	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
715451005425	Coenzyme A binding pocket [chemical binding]; other site
715451005426	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
715451005427	rRNA binding site [nucleotide binding]; other site
715451005428	predicted 30S ribosome binding site; other site
715451005429	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
715451005430	Clp amino terminal domain; Region: Clp_N; pfam02861
715451005431	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451005432	Walker A motif; other site
715451005433	ATP binding site [chemical binding]; other site
715451005434	Walker B motif; other site
715451005435	arginine finger; other site
715451005436	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451005437	Walker A motif; other site
715451005438	ATP binding site [chemical binding]; other site
715451005439	Walker B motif; other site
715451005440	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
715451005441	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
715451005442	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
715451005443	DNA-binding site [nucleotide binding]; DNA binding site
715451005444	RNA-binding motif; other site
715451005445	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
715451005446	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
715451005447	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
715451005448	pseudouridine synthase; Region: TIGR00093
715451005449	probable active site [active]
715451005450	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
715451005451	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
715451005452	putative lysogenization regulator; Reviewed; Region: PRK00218
715451005453	adenylosuccinate lyase; Provisional; Region: PRK09285
715451005454	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
715451005455	tetramer interface [polypeptide binding]; other site
715451005456	active site
715451005457	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
715451005458	cyclase homology domain; Region: CHD; cd07302
715451005459	nucleotidyl binding site; other site
715451005460	metal binding site [ion binding]; metal-binding site
715451005461	dimer interface [polypeptide binding]; other site
715451005462	Cupin superfamily protein; Region: Cupin_4; pfam08007
715451005463	Cupin-like domain; Region: Cupin_8; pfam13621
715451005464	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
715451005465	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
715451005466	FAD binding domain; Region: FAD_binding_4; pfam01565
715451005467	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
715451005468	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
715451005469	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
715451005470	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
715451005471	Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425
715451005472	active site
715451005473	metal binding site [ion binding]; metal-binding site
715451005474	Predicted transcriptional regulators [Transcription]; Region: COG1695
715451005475	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
715451005476	hypothetical protein; Provisional; Region: PRK10039
715451005477	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
715451005478	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
715451005479	putative C-terminal domain interface [polypeptide binding]; other site
715451005480	putative dimer interface [polypeptide binding]; other site
715451005481	putative GSH binding site (G-site) [chemical binding]; other site
715451005482	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
715451005483	N-terminal domain interface [polypeptide binding]; other site
715451005484	dimer interface [polypeptide binding]; other site
715451005485	substrate binding pocket (H-site) [chemical binding]; other site
715451005486	Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567
715451005487	Protein of unknown function (DUF998); Region: DUF998; pfam06197
715451005488	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
715451005489	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
715451005490	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
715451005491	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
715451005492	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
715451005493	classical (c) SDRs; Region: SDR_c; cd05233
715451005494	NAD(P) binding site [chemical binding]; other site
715451005495	active site
715451005496	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
715451005497	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451005498	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451005499	Alginate lyase; Region: Alginate_lyase2; pfam08787
715451005500	Transcriptional regulators [Transcription]; Region: PurR; COG1609
715451005501	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
715451005502	DNA binding site [nucleotide binding]
715451005503	domain linker motif; other site
715451005504	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
715451005505	dimerization interface [polypeptide binding]; other site
715451005506	ligand binding site [chemical binding]; other site
715451005507	Predicted permeases [General function prediction only]; Region: COG0679
715451005508	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
715451005509	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
715451005510	catalytic loop [active]
715451005511	iron binding site [ion binding]; other site
715451005512	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
715451005513	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
715451005514	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
715451005515	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
715451005516	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
715451005517	phosphoenolpyruvate synthase; Validated; Region: PRK06464
715451005518	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
715451005519	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
715451005520	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
715451005521	PEP synthetase regulatory protein; Provisional; Region: PRK05339
715451005522	rhombotail lipoprotein; Region: rhombo_lipo; TIGR04179
715451005523	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
715451005524	active site 1 [active]
715451005525	dimer interface [polypeptide binding]; other site
715451005526	hexamer interface [polypeptide binding]; other site
715451005527	active site 2 [active]
715451005528	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
715451005529	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
715451005530	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
715451005531	RDD family; Region: RDD; pfam06271
715451005532	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
715451005533	Peptidase family M23; Region: Peptidase_M23; pfam01551
715451005534	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
715451005535	active site
715451005536	Zn binding site [ion binding]; other site
715451005537	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
715451005538	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
715451005539	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451005540	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451005541	metal binding site [ion binding]; metal-binding site
715451005542	active site
715451005543	I-site; other site
715451005544	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
715451005545	NADH(P)-binding; Region: NAD_binding_10; pfam13460
715451005546	NAD(P) binding site [chemical binding]; other site
715451005547	putative active site [active]
715451005548	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
715451005549	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
715451005550	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
715451005551	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
715451005552	active site
715451005553	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
715451005554	DNA polymerase III subunit delta'; Validated; Region: PRK08485
715451005555	thymidylate kinase; Validated; Region: tmk; PRK00698
715451005556	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
715451005557	TMP-binding site; other site
715451005558	ATP-binding site [chemical binding]; other site
715451005559	YceG-like family; Region: YceG; pfam02618
715451005560	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
715451005561	dimerization interface [polypeptide binding]; other site
715451005562	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
715451005563	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
715451005564	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451005565	catalytic residue [active]
715451005566	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
715451005567	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
715451005568	dimer interface [polypeptide binding]; other site
715451005569	active site
715451005570	acyl carrier protein; Provisional; Region: acpP; PRK00982
715451005571	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
715451005572	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
715451005573	NAD(P) binding site [chemical binding]; other site
715451005574	homotetramer interface [polypeptide binding]; other site
715451005575	homodimer interface [polypeptide binding]; other site
715451005576	active site
715451005577	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
715451005578	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
715451005579	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
715451005580	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
715451005581	dimer interface [polypeptide binding]; other site
715451005582	active site
715451005583	CoA binding pocket [chemical binding]; other site
715451005584	putative phosphate acyltransferase; Provisional; Region: PRK05331
715451005585	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
715451005586	hypothetical protein; Provisional; Region: PRK11193
715451005587	Maf-like protein; Region: Maf; pfam02545
715451005588	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
715451005589	active site
715451005590	dimer interface [polypeptide binding]; other site
715451005591	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
715451005592	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
715451005593	motif II; other site
715451005594	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
715451005595	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
715451005596	RNA binding surface [nucleotide binding]; other site
715451005597	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
715451005598	active site
715451005599	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
715451005600	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
715451005601	homodimer interface [polypeptide binding]; other site
715451005602	oligonucleotide binding site [chemical binding]; other site
715451005603	Ecdysteroid kinase; Region: EcKinase; cl17738
715451005604	Phosphotransferase enzyme family; Region: APH; pfam01636
715451005605	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
715451005606	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451005607	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
715451005608	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
715451005609	motif II; other site
715451005610	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
715451005611	Coenzyme A binding pocket [chemical binding]; other site
715451005612	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451005613	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451005614	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
715451005615	putative effector binding pocket; other site
715451005616	putative dimerization interface [polypeptide binding]; other site
715451005617	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
715451005618	SnoaL-like domain; Region: SnoaL_2; pfam12680
715451005619	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
715451005620	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
715451005621	putative C-terminal domain interface [polypeptide binding]; other site
715451005622	putative GSH binding site (G-site) [chemical binding]; other site
715451005623	putative dimer interface [polypeptide binding]; other site
715451005624	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
715451005625	putative N-terminal domain interface [polypeptide binding]; other site
715451005626	putative dimer interface [polypeptide binding]; other site
715451005627	putative substrate binding pocket (H-site) [chemical binding]; other site
715451005628	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
715451005629	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
715451005630	Bacterial SH3 domain; Region: SH3_4; pfam06347
715451005631	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
715451005632	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
715451005633	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
715451005634	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
715451005635	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
715451005636	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
715451005637	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
715451005638	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
715451005639	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
715451005640	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
715451005641	active site
715451005642	purine riboside binding site [chemical binding]; other site
715451005643	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
715451005644	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
715451005645	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
715451005646	active site
715451005647	interdomain interaction site; other site
715451005648	putative metal-binding site [ion binding]; other site
715451005649	nucleotide binding site [chemical binding]; other site
715451005650	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
715451005651	domain I; other site
715451005652	DNA binding groove [nucleotide binding]
715451005653	phosphate binding site [ion binding]; other site
715451005654	domain II; other site
715451005655	domain III; other site
715451005656	nucleotide binding site [chemical binding]; other site
715451005657	catalytic site [active]
715451005658	domain IV; other site
715451005659	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
715451005660	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
715451005661	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
715451005662	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
715451005663	succinylarginine dihydrolase; Provisional; Region: PRK13281
715451005664	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
715451005665	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
715451005666	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
715451005667	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
715451005668	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
715451005669	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
715451005670	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
715451005671	FtsX-like permease family; Region: FtsX; pfam02687
715451005672	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
715451005673	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
715451005674	Walker A/P-loop; other site
715451005675	ATP binding site [chemical binding]; other site
715451005676	Q-loop/lid; other site
715451005677	ABC transporter signature motif; other site
715451005678	Walker B; other site
715451005679	D-loop; other site
715451005680	H-loop/switch region; other site
715451005681	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
715451005682	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451005683	TIGR03503 family protein; Region: TIGR03503
715451005684	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
715451005685	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
715451005686	active site
715451005687	catalytic site [active]
715451005688	substrate binding site [chemical binding]; other site
715451005689	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
715451005690	RNA/DNA hybrid binding site [nucleotide binding]; other site
715451005691	active site
715451005692	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
715451005693	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
715451005694	NAD(P) binding site [chemical binding]; other site
715451005695	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
715451005696	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
715451005697	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
715451005698	putative RNA binding site [nucleotide binding]; other site
715451005699	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451005700	S-adenosylmethionine binding site [chemical binding]; other site
715451005701	Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834
715451005702	PilZ domain; Region: PilZ; pfam07238
715451005703	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
715451005704	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
715451005705	ATP binding site [chemical binding]; other site
715451005706	putative Mg++ binding site [ion binding]; other site
715451005707	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451005708	nucleotide binding region [chemical binding]; other site
715451005709	ATP-binding site [chemical binding]; other site
715451005710	Helicase associated domain (HA2); Region: HA2; pfam04408
715451005711	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
715451005712	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
715451005713	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
715451005714	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
715451005715	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
715451005716	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451005717	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451005718	metal binding site [ion binding]; metal-binding site
715451005719	active site
715451005720	I-site; other site
715451005721	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
715451005722	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
715451005723	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451005724	N-terminal plug; other site
715451005725	ligand-binding site [chemical binding]; other site
715451005726	Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378
715451005727	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
715451005728	active site
715451005729	metal binding site [ion binding]; metal-binding site
715451005730	Phytase; Region: Phytase; cl17685
715451005731	FOG: CBS domain [General function prediction only]; Region: COG0517
715451005732	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629
715451005733	potential frameshift: common BLAST hit: gi|332141097|ref|YP_004426835.1| putative sensor protein
715451005734	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451005735	dimer interface [polypeptide binding]; other site
715451005736	phosphorylation site [posttranslational modification]
715451005737	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451005738	ATP binding site [chemical binding]; other site
715451005739	Mg2+ binding site [ion binding]; other site
715451005740	G-X-G motif; other site
715451005741	Response regulator receiver domain; Region: Response_reg; pfam00072
715451005742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451005743	active site
715451005744	phosphorylation site [posttranslational modification]
715451005745	intermolecular recognition site; other site
715451005746	dimerization interface [polypeptide binding]; other site
715451005747	Hpt domain; Region: Hpt; pfam01627
715451005748	potential frameshift: common BLAST hit: gi|196156762|ref|YP_002126251.1| ISSod6, transposase
715451005749	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451005750	PAS domain; Region: PAS_9; pfam13426
715451005751	putative active site [active]
715451005752	heme pocket [chemical binding]; other site
715451005753	exonuclease I; Provisional; Region: sbcB; PRK11779
715451005754	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
715451005755	active site
715451005756	catalytic site [active]
715451005757	substrate binding site [chemical binding]; other site
715451005758	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
715451005759	Protein of unknown function (DUF342); Region: DUF342; pfam03961
715451005760	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
715451005761	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
715451005762	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
715451005763	substrate binding pocket [chemical binding]; other site
715451005764	membrane-bound complex binding site; other site
715451005765	hinge residues; other site
715451005766	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451005767	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451005768	metal binding site [ion binding]; metal-binding site
715451005769	active site
715451005770	I-site; other site
715451005771	putative acyltransferase; Provisional; Region: PRK05790
715451005772	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
715451005773	dimer interface [polypeptide binding]; other site
715451005774	active site
715451005775	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
715451005776	DNA binding residues [nucleotide binding]
715451005777	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
715451005778	putative dimer interface [polypeptide binding]; other site
715451005779	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
715451005780	isovaleryl-CoA dehydrogenase; Region: PLN02519
715451005781	substrate binding site [chemical binding]; other site
715451005782	FAD binding site [chemical binding]; other site
715451005783	catalytic base [active]
715451005784	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
715451005785	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
715451005786	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
715451005787	enoyl-CoA hydratase; Provisional; Region: PRK05995
715451005788	substrate binding site [chemical binding]; other site
715451005789	oxyanion hole (OAH) forming residues; other site
715451005790	trimer interface [polypeptide binding]; other site
715451005791	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
715451005792	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
715451005793	ATP-grasp domain; Region: ATP-grasp_4; cl17255
715451005794	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
715451005795	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
715451005796	carboxyltransferase (CT) interaction site; other site
715451005797	biotinylation site [posttranslational modification]; other site
715451005798	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
715451005799	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
715451005800	active site
715451005801	catalytic residues [active]
715451005802	metal binding site [ion binding]; metal-binding site
715451005803	PAS domain S-box; Region: sensory_box; TIGR00229
715451005804	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451005805	putative active site [active]
715451005806	heme pocket [chemical binding]; other site
715451005807	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
715451005808	GAF domain; Region: GAF; pfam01590
715451005809	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451005810	PAS domain; Region: PAS_9; pfam13426
715451005811	putative active site [active]
715451005812	heme pocket [chemical binding]; other site
715451005813	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451005814	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451005815	metal binding site [ion binding]; metal-binding site
715451005816	active site
715451005817	I-site; other site
715451005818	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451005819	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818
715451005820	putative hydrophobic ligand binding site [chemical binding]; other site
715451005821	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
715451005822	active site
715451005823	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
715451005824	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
715451005825	ligand binding site; other site
715451005826	oligomer interface; other site
715451005827	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
715451005828	dimer interface [polypeptide binding]; other site
715451005829	N-terminal domain interface [polypeptide binding]; other site
715451005830	sulfate 1 binding site; other site
715451005831	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
715451005832	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451005833	D-galactonate transporter; Region: 2A0114; TIGR00893
715451005834	putative substrate translocation pore; other site
715451005835	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
715451005836	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
715451005837	active site
715451005838	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
715451005839	active site 2 [active]
715451005840	active site 1 [active]
715451005841	HDOD domain; Region: HDOD; pfam08668
715451005842	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
715451005843	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
715451005844	Fe-S metabolism associated domain; Region: SufE; cl00951
715451005845	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
715451005846	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
715451005847	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
715451005848	putative catalytic site [active]
715451005849	putative phosphate binding site [ion binding]; other site
715451005850	active site
715451005851	metal binding site A [ion binding]; metal-binding site
715451005852	DNA binding site [nucleotide binding]
715451005853	putative AP binding site [nucleotide binding]; other site
715451005854	putative metal binding site B [ion binding]; other site
715451005855	Predicted membrane protein [Function unknown]; Region: COG3235
715451005856	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
715451005857	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
715451005858	active site
715451005859	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
715451005860	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
715451005861	FtsX-like permease family; Region: FtsX; pfam02687
715451005862	PilZ domain; Region: PilZ; pfam07238
715451005863	transcription-repair coupling factor; Provisional; Region: PRK10689
715451005864	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
715451005865	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
715451005866	ATP binding site [chemical binding]; other site
715451005867	putative Mg++ binding site [ion binding]; other site
715451005868	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451005869	nucleotide binding region [chemical binding]; other site
715451005870	ATP-binding site [chemical binding]; other site
715451005871	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
715451005872	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
715451005873	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
715451005874	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
715451005875	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
715451005876	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
715451005877	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
715451005878	transmembrane helices; other site
715451005879	beta-hexosaminidase; Provisional; Region: PRK05337
715451005880	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
715451005881	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
715451005882	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
715451005883	active site
715451005884	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
715451005885	putative deacylase active site [active]
715451005886	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
715451005887	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
715451005888	IHF dimer interface [polypeptide binding]; other site
715451005889	IHF - DNA interface [nucleotide binding]; other site
715451005890	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
715451005891	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
715451005892	putative tRNA-binding site [nucleotide binding]; other site
715451005893	B3/4 domain; Region: B3_4; pfam03483
715451005894	tRNA synthetase B5 domain; Region: B5; smart00874
715451005895	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
715451005896	dimer interface [polypeptide binding]; other site
715451005897	motif 1; other site
715451005898	motif 3; other site
715451005899	motif 2; other site
715451005900	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
715451005901	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
715451005902	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
715451005903	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
715451005904	dimer interface [polypeptide binding]; other site
715451005905	motif 1; other site
715451005906	active site
715451005907	motif 2; other site
715451005908	motif 3; other site
715451005909	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
715451005910	active site
715451005911	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
715451005912	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
715451005913	Ligand binding site; other site
715451005914	Putative Catalytic site; other site
715451005915	DXD motif; other site
715451005916	Predicted membrane protein [Function unknown]; Region: COG2246
715451005917	GtrA-like protein; Region: GtrA; pfam04138
715451005918	Acyltransferase family; Region: Acyl_transf_3; pfam01757
715451005919	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
715451005920	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
715451005921	putative ADP-binding pocket [chemical binding]; other site
715451005922	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
715451005923	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
715451005924	OpgC protein; Region: OpgC_C; cl17858
715451005925	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
715451005926	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
715451005927	Substrate binding site; other site
715451005928	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
715451005929	Right handed beta helix region; Region: Beta_helix; pfam13229
715451005930	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
715451005931	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
715451005932	active site
715451005933	potential frameshift: common BLAST hit: gi|315127585|ref|YP_004069588.1| transposase IS66
715451005934	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
715451005935	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
715451005936	colanic acid exporter; Provisional; Region: PRK10459
715451005937	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
715451005938	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
715451005939	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
715451005940	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
715451005941	active site
715451005942	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
715451005943	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
715451005944	active site
715451005945	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
715451005946	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
715451005947	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
715451005948	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
715451005949	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
715451005950	trimer interface [polypeptide binding]; other site
715451005951	active site
715451005952	substrate binding site [chemical binding]; other site
715451005953	CoA binding site [chemical binding]; other site
715451005954	O-Antigen ligase; Region: Wzy_C; pfam04932
715451005955	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
715451005956	putative ADP-binding pocket [chemical binding]; other site
715451005957	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
715451005958	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
715451005959	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
715451005960	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451005961	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451005962	metal binding site [ion binding]; metal-binding site
715451005963	active site
715451005964	I-site; other site
715451005965	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451005966	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
715451005967	O-Antigen ligase; Region: Wzy_C; pfam04932
715451005968	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
715451005969	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
715451005970	Chain length determinant protein; Region: Wzz; pfam02706
715451005971	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
715451005972	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
715451005973	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
715451005974	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
715451005975	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
715451005976	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
715451005977	SLBB domain; Region: SLBB; pfam10531
715451005978	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
715451005979	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
715451005980	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
715451005981	Bacterial sugar transferase; Region: Bac_transf; pfam02397
715451005982	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
715451005983	23S rRNA binding site [nucleotide binding]; other site
715451005984	L21 binding site [polypeptide binding]; other site
715451005985	L13 binding site [polypeptide binding]; other site
715451005986	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
715451005987	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
715451005988	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
715451005989	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
715451005990	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
715451005991	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
715451005992	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
715451005993	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
715451005994	active site
715451005995	dimer interface [polypeptide binding]; other site
715451005996	motif 1; other site
715451005997	motif 2; other site
715451005998	motif 3; other site
715451005999	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
715451006000	anticodon binding site; other site
715451006001	pteridine reductase; Provisional; Region: PRK09135
715451006002	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
715451006003	NAD(P) binding site [chemical binding]; other site
715451006004	active site
715451006005	Protein of unknown function (DUF3080); Region: DUF3080; pfam11279
715451006006	Mechanosensitive ion channel; Region: MS_channel; pfam00924
715451006007	CAAX protease self-immunity; Region: Abi; pfam02517
715451006008	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
715451006009	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
715451006010	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
715451006011	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
715451006012	Amidase; Region: Amidase; cl11426
715451006013	indole-3-acetamide amidohydrolase; Region: PLN02722
715451006014	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
715451006015	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
715451006016	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
715451006017	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
715451006018	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
715451006019	catalytic residue [active]
715451006020	allantoate amidohydrolase; Reviewed; Region: PRK09290
715451006021	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
715451006022	active site
715451006023	metal binding site [ion binding]; metal-binding site
715451006024	dimer interface [polypeptide binding]; other site
715451006025	Cupin domain; Region: Cupin_2; cl17218
715451006026	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
715451006027	active site
715451006028	xanthine permease; Region: pbuX; TIGR03173
715451006029	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451006030	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451006031	Purine nucleoside permease (NUP); Region: NUP; pfam06516
715451006032	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
715451006033	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451006034	dimer interface [polypeptide binding]; other site
715451006035	phosphorylation site [posttranslational modification]
715451006036	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451006037	ATP binding site [chemical binding]; other site
715451006038	Mg2+ binding site [ion binding]; other site
715451006039	G-X-G motif; other site
715451006040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451006041	Response regulator receiver domain; Region: Response_reg; pfam00072
715451006042	active site
715451006043	phosphorylation site [posttranslational modification]
715451006044	intermolecular recognition site; other site
715451006045	dimerization interface [polypeptide binding]; other site
715451006046	Response regulator receiver domain; Region: Response_reg; pfam00072
715451006047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451006048	active site
715451006049	phosphorylation site [posttranslational modification]
715451006050	intermolecular recognition site; other site
715451006051	dimerization interface [polypeptide binding]; other site
715451006052	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451006053	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451006054	metal binding site [ion binding]; metal-binding site
715451006055	active site
715451006056	I-site; other site
715451006057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451006058	active site
715451006059	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
715451006060	phosphorylation site [posttranslational modification]
715451006061	intermolecular recognition site; other site
715451006062	dimerization interface [polypeptide binding]; other site
715451006063	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451006064	putative active site [active]
715451006065	heme pocket [chemical binding]; other site
715451006066	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451006067	metal binding site [ion binding]; metal-binding site
715451006068	active site
715451006069	I-site; other site
715451006070	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451006071	Hpt domain; Region: Hpt; pfam01627
715451006072	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
715451006073	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
715451006074	active site
715451006075	purine riboside binding site [chemical binding]; other site
715451006076	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
715451006077	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
715451006078	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
715451006079	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
715451006080	active site
715451006081	catalytic site [active]
715451006082	tetramer interface [polypeptide binding]; other site
715451006083	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
715451006084	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451006085	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
715451006086	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
715451006087	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
715451006088	catalytic loop [active]
715451006089	iron binding site [ion binding]; other site
715451006090	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
715451006091	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
715451006092	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
715451006093	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
715451006094	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
715451006095	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
715451006096	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
715451006097	XdhC Rossmann domain; Region: XdhC_C; pfam13478
715451006098	putative OHCU decarboxylase; Provisional; Region: PRK13798
715451006099	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
715451006100	active site
715451006101	homotetramer interface [polypeptide binding]; other site
715451006102	guanine deaminase; Provisional; Region: PRK09228
715451006103	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
715451006104	active site
715451006105	Protein of unknown function (DUF989); Region: DUF989; pfam06181
715451006106	Predicted membrane protein [Function unknown]; Region: COG3748
715451006107	Cytochrome c; Region: Cytochrom_C; pfam00034
715451006108	PAS domain S-box; Region: sensory_box; TIGR00229
715451006109	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451006110	putative active site [active]
715451006111	heme pocket [chemical binding]; other site
715451006112	PAS fold; Region: PAS_3; pfam08447
715451006113	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451006114	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451006115	metal binding site [ion binding]; metal-binding site
715451006116	active site
715451006117	I-site; other site
715451006118	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451006119	TPR motif; other site
715451006120	Tetratricopeptide repeat; Region: TPR_12; pfam13424
715451006121	binding surface
715451006122	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451006123	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451006124	metal binding site [ion binding]; metal-binding site
715451006125	active site
715451006126	I-site; other site
715451006127	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
715451006128	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
715451006129	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
715451006130	active site
715451006131	catalytic residues [active]
715451006132	DNA binding site [nucleotide binding]
715451006133	Int/Topo IB signature motif; other site
715451006134	Helix-turn-helix domain; Region: HTH_17; pfam12728
715451006135	serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184
715451006136	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
715451006137	oligomer interface [polypeptide binding]; other site
715451006138	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
715451006139	active site residues [active]
715451006140	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
715451006141	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
715451006142	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
715451006143	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
715451006144	dimer interface [polypeptide binding]; other site
715451006145	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
715451006146	active site
715451006147	Fe binding site [ion binding]; other site
715451006148	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
715451006149	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
715451006150	Uncharacterized conserved protein [Function unknown]; Region: COG3603
715451006151	Family description; Region: ACT_7; pfam13840
715451006152	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
715451006153	HPr interaction site; other site
715451006154	glycerol kinase (GK) interaction site [polypeptide binding]; other site
715451006155	active site
715451006156	phosphorylation site [posttranslational modification]
715451006157	ArsC family; Region: ArsC; pfam03960
715451006158	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
715451006159	putative catalytic residues [active]
715451006160	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
715451006161	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
715451006162	metal binding site [ion binding]; metal-binding site
715451006163	dimer interface [polypeptide binding]; other site
715451006164	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
715451006165	hypothetical protein; Provisional; Region: PRK02877
715451006166	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
715451006167	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
715451006168	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
715451006169	putative active site [active]
715451006170	Zn binding site [ion binding]; other site
715451006171	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451006172	metal binding site [ion binding]; metal-binding site
715451006173	active site
715451006174	I-site; other site
715451006175	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451006176	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
715451006177	homodimer interface [polypeptide binding]; other site
715451006178	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
715451006179	active site pocket [active]
715451006180	phosphoglucomutase; Validated; Region: PRK07564
715451006181	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
715451006182	active site
715451006183	substrate binding site [chemical binding]; other site
715451006184	metal binding site [ion binding]; metal-binding site
715451006185	SeqA protein; Region: SeqA; cl11470
715451006186	MoxR-like ATPases [General function prediction only]; Region: COG0714
715451006187	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451006188	Walker A motif; other site
715451006189	ATP binding site [chemical binding]; other site
715451006190	Walker B motif; other site
715451006191	arginine finger; other site
715451006192	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
715451006193	Protein of unknown function DUF58; Region: DUF58; pfam01882
715451006194	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
715451006195	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
715451006196	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
715451006197	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
715451006198	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
715451006199	active site
715451006200	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
715451006201	Catalytic domain of Protein Kinases; Region: PKc; cd00180
715451006202	active site
715451006203	ATP binding site [chemical binding]; other site
715451006204	substrate binding site [chemical binding]; other site
715451006205	activation loop (A-loop); other site
715451006206	cyanate hydratase; Validated; Region: PRK02866
715451006207	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
715451006208	oligomer interface [polypeptide binding]; other site
715451006209	active site
715451006210	elongation factor G; Reviewed; Region: PRK00007
715451006211	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
715451006212	G1 box; other site
715451006213	putative GEF interaction site [polypeptide binding]; other site
715451006214	GTP/Mg2+ binding site [chemical binding]; other site
715451006215	Switch I region; other site
715451006216	G2 box; other site
715451006217	G3 box; other site
715451006218	Switch II region; other site
715451006219	G4 box; other site
715451006220	G5 box; other site
715451006221	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
715451006222	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
715451006223	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
715451006224	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
715451006225	FtsJ-like methyltransferase; Region: FtsJ; cl17430
715451006226	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
715451006227	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
715451006228	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
715451006229	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
715451006230	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451006231	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
715451006232	dimerization interface [polypeptide binding]; other site
715451006233	substrate binding pocket [chemical binding]; other site
715451006234	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
715451006235	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
715451006236	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
715451006237	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451006238	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451006239	active site
715451006240	phosphorylation site [posttranslational modification]
715451006241	intermolecular recognition site; other site
715451006242	dimerization interface [polypeptide binding]; other site
715451006243	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
715451006244	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
715451006245	Zn2+ binding site [ion binding]; other site
715451006246	Mg2+ binding site [ion binding]; other site
715451006247	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
715451006248	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451006249	peptide chain release factor 1; Validated; Region: prfA; PRK00591
715451006250	This domain is found in peptide chain release factors; Region: PCRF; smart00937
715451006251	RF-1 domain; Region: RF-1; pfam00472
715451006252	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
715451006253	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
715451006254	tRNA; other site
715451006255	putative tRNA binding site [nucleotide binding]; other site
715451006256	putative NADP binding site [chemical binding]; other site
715451006257	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
715451006258	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
715451006259	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
715451006260	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
715451006261	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
715451006262	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
715451006263	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
715451006264	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
715451006265	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
715451006266	active site
715451006267	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451006268	PAS domain; Region: PAS_9; pfam13426
715451006269	putative active site [active]
715451006270	heme pocket [chemical binding]; other site
715451006271	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451006272	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451006273	metal binding site [ion binding]; metal-binding site
715451006274	active site
715451006275	I-site; other site
715451006276	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451006277	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
715451006278	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
715451006279	putative NAD(P) binding site [chemical binding]; other site
715451006280	putative substrate binding site [chemical binding]; other site
715451006281	catalytic Zn binding site [ion binding]; other site
715451006282	structural Zn binding site [ion binding]; other site
715451006283	dimer interface [polypeptide binding]; other site
715451006284	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
715451006285	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
715451006286	5S rRNA interface [nucleotide binding]; other site
715451006287	CTC domain interface [polypeptide binding]; other site
715451006288	L16 interface [polypeptide binding]; other site
715451006289	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
715451006290	putative active site [active]
715451006291	catalytic residue [active]
715451006292	GTP-binding protein YchF; Reviewed; Region: PRK09601
715451006293	YchF GTPase; Region: YchF; cd01900
715451006294	G1 box; other site
715451006295	GTP/Mg2+ binding site [chemical binding]; other site
715451006296	Switch I region; other site
715451006297	G2 box; other site
715451006298	Switch II region; other site
715451006299	G3 box; other site
715451006300	G4 box; other site
715451006301	G5 box; other site
715451006302	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
715451006303	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
715451006304	active site
715451006305	potential protein location (hypothetical protein ambt_11220 [Alteromonas sp. SN2]) that overlaps RNA (tRNA-M)
715451006306	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
715451006307	amino acid carrier protein; Region: agcS; TIGR00835
715451006308	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
715451006309	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
715451006310	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
715451006311	putative trimer interface [polypeptide binding]; other site
715451006312	putative CoA binding site [chemical binding]; other site
715451006313	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
715451006314	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
715451006315	Probable Catalytic site; other site
715451006316	metal-binding site
715451006317	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
715451006318	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
715451006319	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
715451006320	Transposase [DNA replication, recombination, and repair]; Region: COG5433
715451006321	Transposase [DNA replication, recombination, and repair]; Region: COG5433
715451006322	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
715451006323	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
715451006324	acyl-activating enzyme (AAE) consensus motif; other site
715451006325	AMP binding site [chemical binding]; other site
715451006326	active site
715451006327	CoA binding site [chemical binding]; other site
715451006328	Acyltransferase family; Region: Acyl_transf_3; pfam01757
715451006329	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
715451006330	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
715451006331	Acyltransferase family; Region: Acyl_transf_3; pfam01757
715451006332	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
715451006333	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
715451006334	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
715451006335	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
715451006336	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
715451006337	active site
715451006338	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
715451006339	putative ADP-binding pocket [chemical binding]; other site
715451006340	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
715451006341	active site
715451006342	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
715451006343	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
715451006344	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
715451006345	putative catalytic site [active]
715451006346	putative metal binding site [ion binding]; other site
715451006347	putative phosphate binding site [ion binding]; other site
715451006348	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
715451006349	Chain length determinant protein; Region: Wzz; pfam02706
715451006350	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
715451006351	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
715451006352	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
715451006353	SLBB domain; Region: SLBB; pfam10531
715451006354	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
715451006355	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
715451006356	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
715451006357	O-Antigen ligase; Region: Wzy_C; pfam04932
715451006358	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
715451006359	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
715451006360	CoA binding site [chemical binding]; other site
715451006361	active site
715451006362	Uncharacterized conserved protein [Function unknown]; Region: COG2128
715451006363	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
715451006364	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451006365	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849
715451006366	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
715451006367	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
715451006368	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
715451006369	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
715451006370	FeS/SAM binding site; other site
715451006371	TRAM domain; Region: TRAM; pfam01938
715451006372	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
715451006373	PhoH-like protein; Region: PhoH; pfam02562
715451006374	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
715451006375	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
715451006376	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
715451006377	Transporter associated domain; Region: CorC_HlyC; smart01091
715451006378	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
715451006379	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
715451006380	putative active site [active]
715451006381	catalytic triad [active]
715451006382	putative dimer interface [polypeptide binding]; other site
715451006383	phosphate acetyltransferase; Reviewed; Region: PRK05632
715451006384	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
715451006385	DRTGG domain; Region: DRTGG; pfam07085
715451006386	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
715451006387	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
715451006388	propionate/acetate kinase; Provisional; Region: PRK12379
715451006389	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
715451006390	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
715451006391	putative dimer interface [polypeptide binding]; other site
715451006392	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
715451006393	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
715451006394	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
715451006395	dimer interface [polypeptide binding]; other site
715451006396	ADP-ribose binding site [chemical binding]; other site
715451006397	active site
715451006398	nudix motif; other site
715451006399	metal binding site [ion binding]; metal-binding site
715451006400	Nitrate and nitrite sensing; Region: NIT; pfam08376
715451006401	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
715451006402	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
715451006403	dimerization interface [polypeptide binding]; other site
715451006404	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
715451006405	dimer interface [polypeptide binding]; other site
715451006406	putative CheW interface [polypeptide binding]; other site
715451006407	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
715451006408	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
715451006409	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
715451006410	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
715451006411	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
715451006412	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
715451006413	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
715451006414	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
715451006415	ATP-grasp domain; Region: ATP-grasp_4; cl17255
715451006416	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
715451006417	IMP binding site; other site
715451006418	dimer interface [polypeptide binding]; other site
715451006419	interdomain contacts; other site
715451006420	partial ornithine binding site; other site
715451006421	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
715451006422	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
715451006423	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
715451006424	catalytic site [active]
715451006425	subunit interface [polypeptide binding]; other site
715451006426	dihydrodipicolinate reductase; Provisional; Region: PRK00048
715451006427	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
715451006428	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
715451006429	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
715451006430	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
715451006431	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
715451006432	acyl-activating enzyme (AAE) consensus motif; other site
715451006433	putative AMP binding site [chemical binding]; other site
715451006434	putative active site [active]
715451006435	putative CoA binding site [chemical binding]; other site
715451006436	PAS domain; Region: PAS_9; pfam13426
715451006437	PAS domain S-box; Region: sensory_box; TIGR00229
715451006438	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451006439	putative active site [active]
715451006440	heme pocket [chemical binding]; other site
715451006441	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451006442	metal binding site [ion binding]; metal-binding site
715451006443	active site
715451006444	I-site; other site
715451006445	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451006446	Cytochrome C' Region: Cytochrom_C_2; pfam01322
715451006447	chaperone protein DnaJ; Provisional; Region: PRK10767
715451006448	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
715451006449	HSP70 interaction site [polypeptide binding]; other site
715451006450	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
715451006451	substrate binding site [polypeptide binding]; other site
715451006452	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
715451006453	Zn binding sites [ion binding]; other site
715451006454	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
715451006455	dimer interface [polypeptide binding]; other site
715451006456	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
715451006457	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
715451006458	nucleotide binding site [chemical binding]; other site
715451006459	GrpE; Region: GrpE; pfam01025
715451006460	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
715451006461	dimer interface [polypeptide binding]; other site
715451006462	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
715451006463	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
715451006464	PAS fold; Region: PAS_7; pfam12860
715451006465	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451006466	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451006467	ATP binding site [chemical binding]; other site
715451006468	Mg2+ binding site [ion binding]; other site
715451006469	G-X-G motif; other site
715451006470	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451006471	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451006472	active site
715451006473	phosphorylation site [posttranslational modification]
715451006474	intermolecular recognition site; other site
715451006475	dimerization interface [polypeptide binding]; other site
715451006476	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
715451006477	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451006478	active site
715451006479	phosphorylation site [posttranslational modification]
715451006480	intermolecular recognition site; other site
715451006481	dimerization interface [polypeptide binding]; other site
715451006482	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
715451006483	DNA binding residues [nucleotide binding]
715451006484	dimerization interface [polypeptide binding]; other site
715451006485	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451006486	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451006487	N-terminal plug; other site
715451006488	ligand-binding site [chemical binding]; other site
715451006489	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
715451006490	fructuronate transporter; Provisional; Region: PRK10034; cl15264
715451006491	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
715451006492	homoserine O-acetyltransferase; Provisional; Region: PRK06765
715451006493	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
715451006494	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
715451006495	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
715451006496	NAD(P) binding site [chemical binding]; other site
715451006497	active site
715451006498	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
715451006499	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
715451006500	AAA ATPase domain; Region: AAA_16; pfam13191
715451006501	recombination and repair protein; Provisional; Region: PRK10869
715451006502	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
715451006503	Walker A/P-loop; other site
715451006504	ATP binding site [chemical binding]; other site
715451006505	Q-loop/lid; other site
715451006506	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
715451006507	ABC transporter signature motif; other site
715451006508	Walker B; other site
715451006509	D-loop; other site
715451006510	H-loop/switch region; other site
715451006511	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
715451006512	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
715451006513	thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840
715451006514	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
715451006515	Na binding site [ion binding]; other site
715451006516	Predicted membrane protein [Function unknown]; Region: COG2733
715451006517	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
715451006518	ArsC family; Region: ArsC; pfam03960
715451006519	catalytic residues [active]
715451006520	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
715451006521	maltose O-acetyltransferase; Provisional; Region: PRK10092
715451006522	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
715451006523	active site
715451006524	substrate binding site [chemical binding]; other site
715451006525	trimer interface [polypeptide binding]; other site
715451006526	CoA binding site [chemical binding]; other site
715451006527	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
715451006528	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
715451006529	active site
715451006530	catalytic tetrad [active]
715451006531	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
715451006532	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
715451006533	RNA binding surface [nucleotide binding]; other site
715451006534	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
715451006535	probable active site [active]
715451006536	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
715451006537	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
715451006538	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
715451006539	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
715451006540	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
715451006541	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
715451006542	anthranilate synthase component I; Provisional; Region: PRK13564
715451006543	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
715451006544	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
715451006545	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
715451006546	Glutamine amidotransferase class-I; Region: GATase; pfam00117
715451006547	glutamine binding [chemical binding]; other site
715451006548	catalytic triad [active]
715451006549	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
715451006550	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
715451006551	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
715451006552	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
715451006553	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
715451006554	active site
715451006555	ribulose/triose binding site [chemical binding]; other site
715451006556	phosphate binding site [ion binding]; other site
715451006557	substrate (anthranilate) binding pocket [chemical binding]; other site
715451006558	product (indole) binding pocket [chemical binding]; other site
715451006559	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
715451006560	active site
715451006561	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
715451006562	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
715451006563	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451006564	catalytic residue [active]
715451006565	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
715451006566	substrate binding site [chemical binding]; other site
715451006567	active site
715451006568	catalytic residues [active]
715451006569	heterodimer interface [polypeptide binding]; other site
715451006570	YciI-like protein; Reviewed; Region: PRK11370
715451006571	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
715451006572	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
715451006573	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
715451006574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451006575	active site
715451006576	phosphorylation site [posttranslational modification]
715451006577	intermolecular recognition site; other site
715451006578	dimerization interface [polypeptide binding]; other site
715451006579	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451006580	DNA binding site [nucleotide binding]
715451006581	sensor protein PhoQ; Provisional; Region: PRK10815
715451006582	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451006583	ATP binding site [chemical binding]; other site
715451006584	Mg2+ binding site [ion binding]; other site
715451006585	G-X-G motif; other site
715451006586	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
715451006587	Domain of unknown function DUF20; Region: UPF0118; pfam01594
715451006588	D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase; Provisional; Region: folX; PRK11245
715451006589	active site
715451006590	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
715451006591	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
715451006592	putative NAD(P) binding site [chemical binding]; other site
715451006593	putative active site [active]
715451006594	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
715451006595	FtsX-like permease family; Region: FtsX; pfam02687
715451006596	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
715451006597	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
715451006598	Walker A/P-loop; other site
715451006599	ATP binding site [chemical binding]; other site
715451006600	Q-loop/lid; other site
715451006601	ABC transporter signature motif; other site
715451006602	Walker B; other site
715451006603	D-loop; other site
715451006604	H-loop/switch region; other site
715451006605	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
715451006606	active site
715451006607	catalytic triad [active]
715451006608	oxyanion hole [active]
715451006609	switch loop; other site
715451006610	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
715451006611	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
715451006612	FMN binding site [chemical binding]; other site
715451006613	active site
715451006614	catalytic residues [active]
715451006615	substrate binding site [chemical binding]; other site
715451006616	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231
715451006617	putative active site [active]
715451006618	Zn binding site [ion binding]; other site
715451006619	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
715451006620	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
715451006621	HIGH motif; other site
715451006622	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
715451006623	active site
715451006624	KMSKS motif; other site
715451006625	potential protein location (hypothetical protein ambt_11760 [Alteromonas sp. SN2]) that overlaps RNA (tRNA-V)
715451006626	Response regulator receiver domain; Region: Response_reg; pfam00072
715451006627	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451006628	active site
715451006629	phosphorylation site [posttranslational modification]
715451006630	intermolecular recognition site; other site
715451006631	dimerization interface [polypeptide binding]; other site
715451006632	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451006633	TPR motif; other site
715451006634	binding surface
715451006635	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
715451006636	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
715451006637	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
715451006638	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
715451006639	FeS/SAM binding site; other site
715451006640	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
715451006641	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
715451006642	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
715451006643	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451006644	Walker A/P-loop; other site
715451006645	ATP binding site [chemical binding]; other site
715451006646	Q-loop/lid; other site
715451006647	ABC transporter signature motif; other site
715451006648	Walker B; other site
715451006649	D-loop; other site
715451006650	H-loop/switch region; other site
715451006651	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
715451006652	Major Facilitator Superfamily; Region: MFS_1; pfam07690
715451006653	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451006654	putative substrate translocation pore; other site
715451006655	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
715451006656	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
715451006657	vitamin B12-transporter ATPase; Provisional; Region: PRK03695
715451006658	Walker A/P-loop; other site
715451006659	ATP binding site [chemical binding]; other site
715451006660	Q-loop/lid; other site
715451006661	ABC transporter signature motif; other site
715451006662	Walker B; other site
715451006663	D-loop; other site
715451006664	H-loop/switch region; other site
715451006665	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
715451006666	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
715451006667	ABC-ATPase subunit  interface; other site
715451006668	dimer interface [polypeptide binding]; other site
715451006669	putative PBP binding regions; other site
715451006670	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
715451006671	Low molecular weight phosphatase family; Region: LMWPc; cd00115
715451006672	active site
715451006673	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
715451006674	active site pocket [active]
715451006675	oxyanion hole [active]
715451006676	catalytic triad [active]
715451006677	active site nucleophile [active]
715451006678	AAA domain; Region: AAA_26; pfam13500
715451006679	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
715451006680	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
715451006681	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451006682	S-adenosylmethionine binding site [chemical binding]; other site
715451006683	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
715451006684	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
715451006685	substrate-cofactor binding pocket; other site
715451006686	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451006687	catalytic residue [active]
715451006688	biotin synthase; Provisional; Region: PRK15108
715451006689	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
715451006690	FeS/SAM binding site; other site
715451006691	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
715451006692	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
715451006693	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
715451006694	inhibitor-cofactor binding pocket; inhibition site
715451006695	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451006696	catalytic residue [active]
715451006697	Protein of unknown function (DUF2937); Region: DUF2937; pfam11157
715451006698	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
715451006699	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
715451006700	Coenzyme A binding pocket [chemical binding]; other site
715451006701	Peptidase_C39 like family; Region: DUF3335; pfam11814
715451006702	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
715451006703	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
715451006704	ATP-grasp domain; Region: ATP-grasp_4; cl17255
715451006705	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
715451006706	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
715451006707	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
715451006708	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
715451006709	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
715451006710	putative dimer interface [polypeptide binding]; other site
715451006711	putative anticodon binding site; other site
715451006712	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
715451006713	homodimer interface [polypeptide binding]; other site
715451006714	motif 1; other site
715451006715	motif 2; other site
715451006716	active site
715451006717	motif 3; other site
715451006718	Paraquat-inducible protein A; Region: PqiA; pfam04403
715451006719	Paraquat-inducible protein A; Region: PqiA; pfam04403
715451006720	paraquat-inducible protein B; Provisional; Region: PRK10807
715451006721	mce related protein; Region: MCE; pfam02470
715451006722	mce related protein; Region: MCE; pfam02470
715451006723	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
715451006724	Protein of unknown function (DUF330); Region: DUF330; pfam03886
715451006725	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451006726	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451006727	metal binding site [ion binding]; metal-binding site
715451006728	active site
715451006729	I-site; other site
715451006730	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
715451006731	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451006732	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
715451006733	Protein export membrane protein; Region: SecD_SecF; cl14618
715451006734	Protein export membrane protein; Region: SecD_SecF; cl14618
715451006735	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
715451006736	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451006737	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
715451006738	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
715451006739	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451006740	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
715451006741	FOG: CBS domain [General function prediction only]; Region: COG0517
715451006742	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_24; cd04637
715451006743	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
715451006744	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
715451006745	putative NAD(P) binding site [chemical binding]; other site
715451006746	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
715451006747	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
715451006748	putative NAD(P) binding site [chemical binding]; other site
715451006749	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451006750	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
715451006751	putative effector binding pocket; other site
715451006752	dimerization interface [polypeptide binding]; other site
715451006753	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
715451006754	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
715451006755	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
715451006756	tetramer interface [polypeptide binding]; other site
715451006757	heme binding pocket [chemical binding]; other site
715451006758	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
715451006759	domain interactions; other site
715451006760	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
715451006761	NAD(P) binding site [chemical binding]; other site
715451006762	active site
715451006763	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
715451006764	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
715451006765	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
715451006766	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
715451006767	2-dehydropantoate 2-reductase; Provisional; Region: PRK08229
715451006768	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
715451006769	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
715451006770	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
715451006771	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
715451006772	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451006773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451006774	putative substrate translocation pore; other site
715451006775	Tetratricopeptide repeat; Region: TPR_12; pfam13424
715451006776	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451006777	binding surface
715451006778	TPR motif; other site
715451006779	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451006780	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451006781	dimer interface [polypeptide binding]; other site
715451006782	phosphorylation site [posttranslational modification]
715451006783	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451006784	ATP binding site [chemical binding]; other site
715451006785	Mg2+ binding site [ion binding]; other site
715451006786	G-X-G motif; other site
715451006787	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451006788	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451006789	active site
715451006790	phosphorylation site [posttranslational modification]
715451006791	intermolecular recognition site; other site
715451006792	dimerization interface [polypeptide binding]; other site
715451006793	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
715451006794	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
715451006795	cell division protein FtsZ; Validated; Region: PRK09330
715451006796	nucleotide binding site [chemical binding]; other site
715451006797	SulA interaction site; other site
715451006798	HTH domain; Region: HTH_11; cl17392
715451006799	WYL domain; Region: WYL; pfam13280
715451006800	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
715451006801	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
715451006802	active site
715451006803	HopJ type III effector protein; Region: HopJ; pfam08888
715451006804	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451006805	I-site; other site
715451006806	active site
715451006807	metal binding site [ion binding]; metal-binding site
715451006808	Uncharacterized conserved protein [Function unknown]; Region: COG0397
715451006809	hypothetical protein; Validated; Region: PRK00029
715451006810	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
715451006811	quinolinate synthetase; Provisional; Region: PRK09375
715451006812	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
715451006813	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451006814	binding surface
715451006815	TPR motif; other site
715451006816	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
715451006817	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
715451006818	ligand binding site [chemical binding]; other site
715451006819	translocation protein TolB; Provisional; Region: tolB; PRK04792
715451006820	TolB amino-terminal domain; Region: TolB_N; pfam04052
715451006821	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
715451006822	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
715451006823	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
715451006824	TolA C-terminal; Region: TolA; pfam06519
715451006825	TolA protein; Region: tolA_full; TIGR02794
715451006826	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
715451006827	TolR protein; Region: tolR; TIGR02801
715451006828	TolQ protein; Region: tolQ; TIGR02796
715451006829	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
715451006830	active site
715451006831	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
715451006832	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451006833	Walker A motif; other site
715451006834	ATP binding site [chemical binding]; other site
715451006835	Walker B motif; other site
715451006836	arginine finger; other site
715451006837	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
715451006838	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
715451006839	RuvA N terminal domain; Region: RuvA_N; pfam01330
715451006840	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
715451006841	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
715451006842	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
715451006843	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
715451006844	active site
715451006845	putative DNA-binding cleft [nucleotide binding]; other site
715451006846	dimer interface [polypeptide binding]; other site
715451006847	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
715451006848	nudix motif; other site
715451006849	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
715451006850	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
715451006851	dimer interface [polypeptide binding]; other site
715451006852	anticodon binding site; other site
715451006853	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
715451006854	homodimer interface [polypeptide binding]; other site
715451006855	motif 1; other site
715451006856	active site
715451006857	motif 2; other site
715451006858	GAD domain; Region: GAD; pfam02938
715451006859	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
715451006860	active site
715451006861	motif 3; other site
715451006862	Protein of unknown function DUF72; Region: DUF72; cl00777
715451006863	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
715451006864	GAF domain; Region: GAF; pfam01590
715451006865	response regulator GlrR; Provisional; Region: PRK15115
715451006866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451006867	active site
715451006868	phosphorylation site [posttranslational modification]
715451006869	intermolecular recognition site; other site
715451006870	dimerization interface [polypeptide binding]; other site
715451006871	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451006872	Walker A motif; other site
715451006873	ATP binding site [chemical binding]; other site
715451006874	Walker B motif; other site
715451006875	arginine finger; other site
715451006876	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
715451006877	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451006878	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451006879	dimer interface [polypeptide binding]; other site
715451006880	phosphorylation site [posttranslational modification]
715451006881	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451006882	ATP binding site [chemical binding]; other site
715451006883	Mg2+ binding site [ion binding]; other site
715451006884	G-X-G motif; other site
715451006885	EF-hand domain pair; Region: EF_hand_5; pfam13499
715451006886	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451006887	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451006888	metal binding site [ion binding]; metal-binding site
715451006889	active site
715451006890	I-site; other site
715451006891	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451006892	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
715451006893	putative metal binding site [ion binding]; other site
715451006894	Response regulator receiver domain; Region: Response_reg; pfam00072
715451006895	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451006896	active site
715451006897	phosphorylation site [posttranslational modification]
715451006898	intermolecular recognition site; other site
715451006899	dimerization interface [polypeptide binding]; other site
715451006900	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
715451006901	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
715451006902	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
715451006903	anti sigma factor interaction site; other site
715451006904	regulatory phosphorylation site [posttranslational modification]; other site
715451006905	translation initiation factor Sui1; Validated; Region: PRK06824
715451006906	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
715451006907	putative rRNA binding site [nucleotide binding]; other site
715451006908	Response regulator receiver domain; Region: Response_reg; pfam00072
715451006909	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451006910	active site
715451006911	phosphorylation site [posttranslational modification]
715451006912	intermolecular recognition site; other site
715451006913	dimerization interface [polypeptide binding]; other site
715451006914	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
715451006915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451006916	active site
715451006917	phosphorylation site [posttranslational modification]
715451006918	intermolecular recognition site; other site
715451006919	dimerization interface [polypeptide binding]; other site
715451006920	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
715451006921	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
715451006922	Prephenate dehydratase; Region: PDT; pfam00800
715451006923	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
715451006924	putative L-Phe binding site [chemical binding]; other site
715451006925	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
715451006926	Chorismate mutase type II; Region: CM_2; cl00693
715451006927	prephenate dehydrogenase; Validated; Region: PRK08507
715451006928	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
715451006929	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
715451006930	Predicted membrane protein [Function unknown]; Region: COG2860
715451006931	UPF0126 domain; Region: UPF0126; pfam03458
715451006932	UPF0126 domain; Region: UPF0126; pfam03458
715451006933	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
715451006934	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
715451006935	nucleophilic elbow; other site
715451006936	catalytic triad; other site
715451006937	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
715451006938	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
715451006939	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
715451006940	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
715451006941	RimM N-terminal domain; Region: RimM; pfam01782
715451006942	PRC-barrel domain; Region: PRC; pfam05239
715451006943	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
715451006944	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
715451006945	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
715451006946	metal binding site [ion binding]; metal-binding site
715451006947	dimer interface [polypeptide binding]; other site
715451006948	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
715451006949	catalytic residues [active]
715451006950	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
715451006951	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
715451006952	homodimer interface [polypeptide binding]; other site
715451006953	substrate-cofactor binding pocket; other site
715451006954	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451006955	catalytic residue [active]
715451006956	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
715451006957	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
715451006958	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451006959	Walker A/P-loop; other site
715451006960	ATP binding site [chemical binding]; other site
715451006961	Q-loop/lid; other site
715451006962	ABC transporter signature motif; other site
715451006963	Walker B; other site
715451006964	D-loop; other site
715451006965	H-loop/switch region; other site
715451006966	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
715451006967	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
715451006968	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451006969	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
715451006970	Protein export membrane protein; Region: SecD_SecF; cl14618
715451006971	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
715451006972	tellurium resistance terB-like protein; Region: terB_like; cl11965
715451006973	metal binding site [ion binding]; metal-binding site
715451006974	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
715451006975	signal recognition particle protein; Provisional; Region: PRK10867
715451006976	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
715451006977	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
715451006978	P loop; other site
715451006979	GTP binding site [chemical binding]; other site
715451006980	Signal peptide binding domain; Region: SRP_SPB; pfam02978
715451006981	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
715451006982	Domain of unknown function DUF21; Region: DUF21; pfam01595
715451006983	hypothetical protein; Provisional; Region: PRK11573
715451006984	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
715451006985	Transporter associated domain; Region: CorC_HlyC; smart01091
715451006986	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
715451006987	catalytic core [active]
715451006988	Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025
715451006989	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
715451006990	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
715451006991	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
715451006992	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
715451006993	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
715451006994	PAS fold; Region: PAS_3; pfam08447
715451006995	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451006996	PAS domain; Region: PAS_9; pfam13426
715451006997	putative active site [active]
715451006998	heme pocket [chemical binding]; other site
715451006999	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451007000	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451007001	metal binding site [ion binding]; metal-binding site
715451007002	active site
715451007003	I-site; other site
715451007004	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451007005	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
715451007006	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
715451007007	substrate binding site [chemical binding]; other site
715451007008	oxyanion hole (OAH) forming residues; other site
715451007009	trimer interface [polypeptide binding]; other site
715451007010	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
715451007011	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
715451007012	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
715451007013	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
715451007014	dimer interface [polypeptide binding]; other site
715451007015	active site
715451007016	MoxR-like ATPases [General function prediction only]; Region: COG0714
715451007017	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451007018	Walker A motif; other site
715451007019	ATP binding site [chemical binding]; other site
715451007020	Walker B motif; other site
715451007021	arginine finger; other site
715451007022	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
715451007023	Protein of unknown function DUF58; Region: DUF58; pfam01882
715451007024	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
715451007025	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
715451007026	metal ion-dependent adhesion site (MIDAS); other site
715451007027	von Willebrand factor type A domain; Region: VWA_2; pfam13519
715451007028	metal ion-dependent adhesion site (MIDAS); other site
715451007029	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451007030	Tetratricopeptide repeat; Region: TPR_16; pfam13432
715451007031	TPR motif; other site
715451007032	binding surface
715451007033	Oxygen tolerance; Region: BatD; pfam13584
715451007034	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
715451007035	RNA polymerase sigma factor; Provisional; Region: PRK12517
715451007036	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451007037	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
715451007038	DNA binding residues [nucleotide binding]
715451007039	Protein of unknown function (DUF3379); Region: DUF3379; pfam11859
715451007040	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451007041	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451007042	metal binding site [ion binding]; metal-binding site
715451007043	active site
715451007044	I-site; other site
715451007045	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
715451007046	Na binding site [ion binding]; other site
715451007047	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
715451007048	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
715451007049	Active Sites [active]
715451007050	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
715451007051	AAA domain; Region: AAA_18; pfam13238
715451007052	ligand-binding site [chemical binding]; other site
715451007053	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
715451007054	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
715451007055	active site
715451007056	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
715451007057	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
715451007058	CysD dimerization site [polypeptide binding]; other site
715451007059	G1 box; other site
715451007060	putative GEF interaction site [polypeptide binding]; other site
715451007061	GTP/Mg2+ binding site [chemical binding]; other site
715451007062	Switch I region; other site
715451007063	G2 box; other site
715451007064	G3 box; other site
715451007065	Switch II region; other site
715451007066	G4 box; other site
715451007067	G5 box; other site
715451007068	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
715451007069	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
715451007070	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
715451007071	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
715451007072	TrkA-C domain; Region: TrkA_C; pfam02080
715451007073	TrkA-C domain; Region: TrkA_C; pfam02080
715451007074	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
715451007075	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
715451007076	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
715451007077	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
715451007078	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
715451007079	PA/protease or protease-like domain interface [polypeptide binding]; other site
715451007080	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
715451007081	metal binding site [ion binding]; metal-binding site
715451007082	Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582
715451007083	asparagine synthetase B; Provisional; Region: asnB; PRK09431
715451007084	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
715451007085	active site
715451007086	dimer interface [polypeptide binding]; other site
715451007087	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
715451007088	Ligand Binding Site [chemical binding]; other site
715451007089	Molecular Tunnel; other site
715451007090	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
715451007091	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
715451007092	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
715451007093	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
715451007094	Ligand Binding Site [chemical binding]; other site
715451007095	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451007096	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451007097	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
715451007098	dimerization interface [polypeptide binding]; other site
715451007099	excinuclease ABC subunit B; Provisional; Region: PRK05298
715451007100	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
715451007101	ATP binding site [chemical binding]; other site
715451007102	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451007103	nucleotide binding region [chemical binding]; other site
715451007104	ATP-binding site [chemical binding]; other site
715451007105	Ultra-violet resistance protein B; Region: UvrB; pfam12344
715451007106	UvrB/uvrC motif; Region: UVR; pfam02151
715451007107	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
715451007108	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_2; cd13149
715451007109	electron transport complex protein RsxA; Provisional; Region: PRK05151
715451007110	electron transport complex protein RnfB; Provisional; Region: PRK05113
715451007111	Putative Fe-S cluster; Region: FeS; pfam04060
715451007112	4Fe-4S binding domain; Region: Fer4; pfam00037
715451007113	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
715451007114	SLBB domain; Region: SLBB; pfam10531
715451007115	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
715451007116	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
715451007117	electron transport complex protein RnfG; Validated; Region: PRK01908
715451007118	electron transport complex RsxE subunit; Provisional; Region: PRK12405
715451007119	endonuclease III; Provisional; Region: PRK10702
715451007120	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
715451007121	minor groove reading motif; other site
715451007122	helix-hairpin-helix signature motif; other site
715451007123	substrate binding pocket [chemical binding]; other site
715451007124	active site
715451007125	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
715451007126	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
715451007127	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
715451007128	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
715451007129	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
715451007130	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
715451007131	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
715451007132	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
715451007133	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
715451007134	PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815
715451007135	PA/protease or protease-like domain interface [polypeptide binding]; other site
715451007136	M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883
715451007137	Peptidase family M28; Region: Peptidase_M28; pfam04389
715451007138	metal binding site [ion binding]; metal-binding site
715451007139	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
715451007140	Tetratricopeptide repeat; Region: TPR_16; pfam13432
715451007141	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451007142	TPR motif; other site
715451007143	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
715451007144	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451007145	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451007146	metal binding site [ion binding]; metal-binding site
715451007147	active site
715451007148	I-site; other site
715451007149	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
715451007150	DNA-binding site [nucleotide binding]; DNA binding site
715451007151	RNA-binding motif; other site
715451007152	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
715451007153	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
715451007154	dimer interface [polypeptide binding]; other site
715451007155	active site
715451007156	metal binding site [ion binding]; metal-binding site
715451007157	glutathione binding site [chemical binding]; other site
715451007158	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
715451007159	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
715451007160	active site
715451007161	catalytic site [active]
715451007162	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
715451007163	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
715451007164	ligand binding site [chemical binding]; other site
715451007165	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
715451007166	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
715451007167	dimer interface [polypeptide binding]; other site
715451007168	catalytic site [active]
715451007169	putative active site [active]
715451007170	putative substrate binding site [chemical binding]; other site
715451007171	peroxidase; Provisional; Region: PRK15000
715451007172	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
715451007173	dimer interface [polypeptide binding]; other site
715451007174	decamer (pentamer of dimers) interface [polypeptide binding]; other site
715451007175	catalytic triad [active]
715451007176	peroxidatic and resolving cysteines [active]
715451007177	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
715451007178	Secretin and TonB N terminus short domain; Region: STN; smart00965
715451007179	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451007180	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
715451007181	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451007182	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
715451007183	FecR protein; Region: FecR; pfam04773
715451007184	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
715451007185	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451007186	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
715451007187	DNA binding residues [nucleotide binding]
715451007188	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451007189	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451007190	N-terminal plug; other site
715451007191	ligand-binding site [chemical binding]; other site
715451007192	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
715451007193	putative GSH binding site [chemical binding]; other site
715451007194	catalytic residues [active]
715451007195	superoxide dismutase; Provisional; Region: PRK10543
715451007196	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
715451007197	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
715451007198	PrkA family serine protein kinase; Provisional; Region: PRK15455
715451007199	AAA ATPase domain; Region: AAA_16; pfam13191
715451007200	Walker A motif; other site
715451007201	ATP binding site [chemical binding]; other site
715451007202	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
715451007203	hypothetical protein; Provisional; Region: PRK05325
715451007204	SpoVR family protein; Provisional; Region: PRK11767
715451007205	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
715451007206	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451007207	phenyl proprionate permease family protein; Region: 2A0127; TIGR00902
715451007208	putative substrate translocation pore; other site
715451007209	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
715451007210	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
715451007211	Tetramer interface [polypeptide binding]; other site
715451007212	active site
715451007213	FMN-binding site [chemical binding]; other site
715451007214	HemK family putative methylases; Region: hemK_fam; TIGR00536
715451007215	PRMT5 arginine-N-methyltransferase; Region: PRMT5; cl17640
715451007216	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451007217	S-adenosylmethionine binding site [chemical binding]; other site
715451007218	hypothetical protein; Provisional; Region: PRK04946
715451007219	Smr domain; Region: Smr; pfam01713
715451007220	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451007221	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451007222	ATP binding site [chemical binding]; other site
715451007223	Mg2+ binding site [ion binding]; other site
715451007224	G-X-G motif; other site
715451007225	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
715451007226	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451007227	active site
715451007228	phosphorylation site [posttranslational modification]
715451007229	intermolecular recognition site; other site
715451007230	dimerization interface [polypeptide binding]; other site
715451007231	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451007232	Walker A motif; other site
715451007233	ATP binding site [chemical binding]; other site
715451007234	Walker B motif; other site
715451007235	arginine finger; other site
715451007236	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
715451007237	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
715451007238	FtsX-like permease family; Region: FtsX; pfam02687
715451007239	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
715451007240	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
715451007241	FtsX-like permease family; Region: FtsX; pfam02687
715451007242	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
715451007243	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
715451007244	Walker A/P-loop; other site
715451007245	ATP binding site [chemical binding]; other site
715451007246	Q-loop/lid; other site
715451007247	ABC transporter signature motif; other site
715451007248	Walker B; other site
715451007249	D-loop; other site
715451007250	H-loop/switch region; other site
715451007251	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
715451007252	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451007253	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
715451007254	N-acetyl-D-glucosamine binding site [chemical binding]; other site
715451007255	catalytic residue [active]
715451007256	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
715451007257	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
715451007258	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
715451007259	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
715451007260	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
715451007261	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
715451007262	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
715451007263	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
715451007264	putative binding surface; other site
715451007265	active site
715451007266	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
715451007267	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
715451007268	active site
715451007269	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
715451007270	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
715451007271	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
715451007272	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
715451007273	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
715451007274	dimer interface [polypeptide binding]; other site
715451007275	putative anticodon binding site; other site
715451007276	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
715451007277	motif 1; other site
715451007278	active site
715451007279	motif 2; other site
715451007280	motif 3; other site
715451007281	This domain is found in peptide chain release factors; Region: PCRF; smart00937
715451007282	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
715451007283	RF-1 domain; Region: RF-1; pfam00472
715451007284	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
715451007285	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451007286	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
715451007287	DNA binding residues [nucleotide binding]
715451007288	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
715451007289	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
715451007290	Zn2+ binding site [ion binding]; other site
715451007291	Mg2+ binding site [ion binding]; other site
715451007292	gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409
715451007293	Protein of unknown function (DUF971); Region: DUF971; cl01414
715451007294	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
715451007295	substrate binding pocket [chemical binding]; other site
715451007296	active site
715451007297	iron coordination sites [ion binding]; other site
715451007298	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
715451007299	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451007300	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
715451007301	dimerization interface [polypeptide binding]; other site
715451007302	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
715451007303	Predicted flavoprotein [General function prediction only]; Region: COG0431
715451007304	HAMP domain; Region: HAMP; pfam00672
715451007305	PAS domain S-box; Region: sensory_box; TIGR00229
715451007306	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451007307	putative active site [active]
715451007308	heme pocket [chemical binding]; other site
715451007309	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451007310	PAS domain; Region: PAS_9; pfam13426
715451007311	putative active site [active]
715451007312	heme pocket [chemical binding]; other site
715451007313	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451007314	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451007315	metal binding site [ion binding]; metal-binding site
715451007316	active site
715451007317	I-site; other site
715451007318	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451007319	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
715451007320	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
715451007321	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
715451007322	active site
715451007323	HIGH motif; other site
715451007324	KMSK motif region; other site
715451007325	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
715451007326	tRNA binding surface [nucleotide binding]; other site
715451007327	anticodon binding site; other site
715451007328	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
715451007329	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
715451007330	G1 box; other site
715451007331	putative GEF interaction site [polypeptide binding]; other site
715451007332	GTP/Mg2+ binding site [chemical binding]; other site
715451007333	Switch I region; other site
715451007334	G2 box; other site
715451007335	G3 box; other site
715451007336	Switch II region; other site
715451007337	G4 box; other site
715451007338	G5 box; other site
715451007339	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
715451007340	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
715451007341	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
715451007342	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451007343	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451007344	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
715451007345	dimerization interface [polypeptide binding]; other site
715451007346	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
715451007347	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
715451007348	Transposase [DNA replication, recombination, and repair]; Region: COG5433
715451007349	Transposase [DNA replication, recombination, and repair]; Region: COG5433
715451007350	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451007351	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
715451007352	EamA-like transporter family; Region: EamA; pfam00892
715451007353	EamA-like transporter family; Region: EamA; pfam00892
715451007354	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
715451007355	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
715451007356	Coenzyme A binding pocket [chemical binding]; other site
715451007357	potential frameshift: common BLAST hit: gi|196157754|ref|YP_002127243.1| transposase Tn3
715451007358	Phosphotransferase enzyme family; Region: APH; pfam01636
715451007359	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
715451007360	active site
715451007361	substrate binding site [chemical binding]; other site
715451007362	ATP binding site [chemical binding]; other site
715451007363	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
715451007364	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
715451007365	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451007366	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
715451007367	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
715451007368	Helicase; Region: Helicase_RecD; pfam05127
715451007369	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
715451007370	Coenzyme A binding pocket [chemical binding]; other site
715451007371	TPR repeat; Region: TPR_11; pfam13414
715451007372	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
715451007373	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
715451007374	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
715451007375	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
715451007376	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
715451007377	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
715451007378	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
715451007379	Tetratricopeptide repeat; Region: TPR_16; pfam13432
715451007380	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451007381	TPR motif; other site
715451007382	TPR repeat; Region: TPR_11; pfam13414
715451007383	binding surface
715451007384	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451007385	TPR motif; other site
715451007386	TPR repeat; Region: TPR_11; pfam13414
715451007387	binding surface
715451007388	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759
715451007389	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
715451007390	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
715451007391	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
715451007392	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451007393	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451007394	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451007395	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451007396	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
715451007397	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451007398	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451007399	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
715451007400	Late competence development protein ComFB; Region: ComFB; pfam10719
715451007401	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
715451007402	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
715451007403	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
715451007404	NAD binding site [chemical binding]; other site
715451007405	Phe binding site; other site
715451007406	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
715451007407	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
715451007408	putative DNA binding site [nucleotide binding]; other site
715451007409	putative Zn2+ binding site [ion binding]; other site
715451007410	AsnC family; Region: AsnC_trans_reg; pfam01037
715451007411	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
715451007412	maleylacetoacetate isomerase; Region: maiA; TIGR01262
715451007413	C-terminal domain interface [polypeptide binding]; other site
715451007414	GSH binding site (G-site) [chemical binding]; other site
715451007415	putative dimer interface [polypeptide binding]; other site
715451007416	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
715451007417	dimer interface [polypeptide binding]; other site
715451007418	N-terminal domain interface [polypeptide binding]; other site
715451007419	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
715451007420	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
715451007421	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
715451007422	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
715451007423	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
715451007424	putative aromatic amino acid binding site; other site
715451007425	PAS domain; Region: PAS; smart00091
715451007426	putative active site [active]
715451007427	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451007428	Walker A motif; other site
715451007429	ATP binding site [chemical binding]; other site
715451007430	Walker B motif; other site
715451007431	arginine finger; other site
715451007432	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
715451007433	cofactor binding site; other site
715451007434	metal binding site [ion binding]; metal-binding site
715451007435	phage shock protein C; Region: phageshock_pspC; TIGR02978
715451007436	PspC domain; Region: PspC; pfam04024
715451007437	phage shock protein B; Provisional; Region: pspB; PRK09458
715451007438	phage shock protein A; Region: phageshock_pspA; TIGR02977
715451007439	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
715451007440	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451007441	Walker A motif; other site
715451007442	ATP binding site [chemical binding]; other site
715451007443	Walker B motif; other site
715451007444	arginine finger; other site
715451007445	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
715451007446	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
715451007447	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
715451007448	peptide binding site [polypeptide binding]; other site
715451007449	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
715451007450	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
715451007451	dimer interface [polypeptide binding]; other site
715451007452	conserved gate region; other site
715451007453	putative PBP binding loops; other site
715451007454	ABC-ATPase subunit interface; other site
715451007455	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171
715451007456	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
715451007457	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
715451007458	dimer interface [polypeptide binding]; other site
715451007459	conserved gate region; other site
715451007460	putative PBP binding loops; other site
715451007461	ABC-ATPase subunit interface; other site
715451007462	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170
715451007463	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
715451007464	Walker A/P-loop; other site
715451007465	ATP binding site [chemical binding]; other site
715451007466	Q-loop/lid; other site
715451007467	ABC transporter signature motif; other site
715451007468	Walker B; other site
715451007469	D-loop; other site
715451007470	H-loop/switch region; other site
715451007471	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
715451007472	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167
715451007473	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
715451007474	Walker A/P-loop; other site
715451007475	ATP binding site [chemical binding]; other site
715451007476	Q-loop/lid; other site
715451007477	ABC transporter signature motif; other site
715451007478	Walker B; other site
715451007479	D-loop; other site
715451007480	H-loop/switch region; other site
715451007481	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
715451007482	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
715451007483	oxaloacetate decarboxylase; Provisional; Region: PRK14040
715451007484	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
715451007485	active site
715451007486	catalytic residues [active]
715451007487	metal binding site [ion binding]; metal-binding site
715451007488	homodimer binding site [polypeptide binding]; other site
715451007489	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
715451007490	carboxyltransferase (CT) interaction site; other site
715451007491	biotinylation site [posttranslational modification]; other site
715451007492	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
715451007493	carbon storage regulator; Provisional; Region: PRK01712
715451007494	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
715451007495	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
715451007496	motif 1; other site
715451007497	active site
715451007498	motif 2; other site
715451007499	motif 3; other site
715451007500	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
715451007501	DHHA1 domain; Region: DHHA1; pfam02272
715451007502	recombination regulator RecX; Reviewed; Region: recX; PRK00117
715451007503	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
715451007504	Protein of unknown function, DUF482; Region: DUF482; pfam04339
715451007505	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
715451007506	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
715451007507	active site
715451007508	Zn binding site [ion binding]; other site
715451007509	transcriptional regulator BetI; Validated; Region: PRK00767
715451007510	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451007511	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
715451007512	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451007513	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451007514	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
715451007515	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
715451007516	Sulfate transporter family; Region: Sulfate_transp; pfam00916
715451007517	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
715451007518	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
715451007519	active site clefts [active]
715451007520	zinc binding site [ion binding]; other site
715451007521	dimer interface [polypeptide binding]; other site
715451007522	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
715451007523	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451007524	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
715451007525	dimerization interface [polypeptide binding]; other site
715451007526	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451007527	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451007528	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
715451007529	putative dimerization interface [polypeptide binding]; other site
715451007530	Cache domain; Region: Cache_1; pfam02743
715451007531	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
715451007532	dimerization interface [polypeptide binding]; other site
715451007533	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
715451007534	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
715451007535	dimer interface [polypeptide binding]; other site
715451007536	putative CheW interface [polypeptide binding]; other site
715451007537	Protein of unknown function (DUF938); Region: DUF938; pfam06080
715451007538	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
715451007539	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
715451007540	substrate binding pocket [chemical binding]; other site
715451007541	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
715451007542	B12 binding site [chemical binding]; other site
715451007543	cobalt ligand [ion binding]; other site
715451007544	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
715451007545	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
715451007546	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
715451007547	homoserine O-succinyltransferase; Provisional; Region: PRK05368
715451007548	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
715451007549	proposed active site lysine [active]
715451007550	conserved cys residue [active]
715451007551	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
715451007552	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
715451007553	putative CheA interaction surface; other site
715451007554	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
715451007555	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
715451007556	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
715451007557	Magnesium ion binding site [ion binding]; other site
715451007558	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
715451007559	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451007560	active site
715451007561	phosphorylation site [posttranslational modification]
715451007562	intermolecular recognition site; other site
715451007563	dimerization interface [polypeptide binding]; other site
715451007564	CheB methylesterase; Region: CheB_methylest; pfam01339
715451007565	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
715451007566	putative binding surface; other site
715451007567	active site
715451007568	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
715451007569	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
715451007570	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451007571	ATP binding site [chemical binding]; other site
715451007572	Mg2+ binding site [ion binding]; other site
715451007573	G-X-G motif; other site
715451007574	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
715451007575	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
715451007576	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
715451007577	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451007578	active site
715451007579	phosphorylation site [posttranslational modification]
715451007580	intermolecular recognition site; other site
715451007581	dimerization interface [polypeptide binding]; other site
715451007582	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
715451007583	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451007584	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
715451007585	DNA binding residues [nucleotide binding]
715451007586	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
715451007587	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
715451007588	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
715451007589	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
715451007590	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
715451007591	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
715451007592	FHIPEP family; Region: FHIPEP; pfam00771
715451007593	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
715451007594	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
715451007595	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
715451007596	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
715451007597	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
715451007598	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
715451007599	flagellar motor switch protein; Validated; Region: fliN; PRK08983
715451007600	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
715451007601	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
715451007602	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696
715451007603	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
715451007604	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
715451007605	Flagellar FliJ protein; Region: FliJ; pfam02050
715451007606	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08972
715451007607	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
715451007608	Walker A motif/ATP binding site; other site
715451007609	Walker B motif; other site
715451007610	flagellar assembly protein H; Validated; Region: fliH; PRK05687
715451007611	Flagellar assembly protein FliH; Region: FliH; pfam02108
715451007612	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
715451007613	MgtE intracellular N domain; Region: MgtE_N; smart00924
715451007614	FliG C-terminal domain; Region: FliG_C; pfam01706
715451007615	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
715451007616	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
715451007617	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
715451007618	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
715451007619	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
715451007620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451007621	active site
715451007622	phosphorylation site [posttranslational modification]
715451007623	intermolecular recognition site; other site
715451007624	dimerization interface [polypeptide binding]; other site
715451007625	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451007626	Walker A motif; other site
715451007627	ATP binding site [chemical binding]; other site
715451007628	Walker B motif; other site
715451007629	arginine finger; other site
715451007630	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
715451007631	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
715451007632	PAS domain; Region: PAS_8; pfam13188
715451007633	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451007634	dimer interface [polypeptide binding]; other site
715451007635	phosphorylation site [posttranslational modification]
715451007636	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451007637	ATP binding site [chemical binding]; other site
715451007638	Mg2+ binding site [ion binding]; other site
715451007639	G-X-G motif; other site
715451007640	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
715451007641	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
715451007642	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451007643	Walker A motif; other site
715451007644	ATP binding site [chemical binding]; other site
715451007645	Walker B motif; other site
715451007646	arginine finger; other site
715451007647	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
715451007648	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
715451007649	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
715451007650	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
715451007651	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
715451007652	NAD(P) binding site [chemical binding]; other site
715451007653	homodimer interface [polypeptide binding]; other site
715451007654	substrate binding site [chemical binding]; other site
715451007655	active site
715451007656	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
715451007657	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
715451007658	inhibitor-cofactor binding pocket; inhibition site
715451007659	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451007660	catalytic residue [active]
715451007661	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
715451007662	ligand binding site; other site
715451007663	tetramer interface; other site
715451007664	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
715451007665	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
715451007666	pseudaminic acid synthase; Region: PseI; TIGR03586
715451007667	NeuB family; Region: NeuB; pfam03102
715451007668	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
715451007669	NeuB binding interface [polypeptide binding]; other site
715451007670	putative substrate binding site [chemical binding]; other site
715451007671	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
715451007672	Phosphopantetheine attachment site; Region: PP-binding; cl09936
715451007673	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
715451007674	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
715451007675	AMP binding site [chemical binding]; other site
715451007676	active site
715451007677	acyl-activating enzyme (AAE) consensus motif; other site
715451007678	CoA binding site [chemical binding]; other site
715451007679	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
715451007680	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
715451007681	NAD(P) binding site [chemical binding]; other site
715451007682	active site
715451007683	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
715451007684	Methyltransferase domain; Region: Methyltransf_24; pfam13578
715451007685	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
715451007686	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
715451007687	inhibitor-cofactor binding pocket; inhibition site
715451007688	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451007689	catalytic residue [active]
715451007690	WbqC-like protein family; Region: WbqC; pfam08889
715451007691	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
715451007692	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
715451007693	putative trimer interface [polypeptide binding]; other site
715451007694	putative CoA binding site [chemical binding]; other site
715451007695	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
715451007696	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451007697	S-adenosylmethionine binding site [chemical binding]; other site
715451007698	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929
715451007699	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
715451007700	flagellar protein FliS; Validated; Region: fliS; PRK05685
715451007701	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
715451007702	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
715451007703	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
715451007704	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
715451007705	FlaG protein; Region: FlaG; pfam03646
715451007706	flagellin; Provisional; Region: PRK12802
715451007707	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
715451007708	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
715451007709	flagellin; Provisional; Region: PRK12802
715451007710	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
715451007711	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
715451007712	flagellin; Provisional; Region: PRK12802
715451007713	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
715451007714	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
715451007715	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
715451007716	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
715451007717	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
715451007718	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683
715451007719	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
715451007720	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
715451007721	Rod binding protein; Region: Rod-binding; cl01626
715451007722	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
715451007723	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
715451007724	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
715451007725	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
715451007726	Flagellar L-ring protein; Region: FlgH; pfam02107
715451007727	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
715451007728	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
715451007729	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
715451007730	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
715451007731	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
715451007732	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
715451007733	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
715451007734	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
715451007735	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
715451007736	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
715451007737	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
715451007738	flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12631
715451007739	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
715451007740	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12625
715451007741	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
715451007742	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
715451007743	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
715451007744	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
715451007745	Response regulator receiver domain; Region: Response_reg; pfam00072
715451007746	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451007747	active site
715451007748	phosphorylation site [posttranslational modification]
715451007749	intermolecular recognition site; other site
715451007750	dimerization interface [polypeptide binding]; other site
715451007751	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
715451007752	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
715451007753	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
715451007754	FlgN protein; Region: FlgN; pfam05130
715451007755	LPP20 lipoprotein; Region: LPP20; pfam02169
715451007756	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
715451007757	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
715451007758	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451007759	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
715451007760	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
715451007761	DNA binding residues [nucleotide binding]
715451007762	dimerization interface [polypeptide binding]; other site
715451007763	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
715451007764	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
715451007765	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451007766	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
715451007767	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
715451007768	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
715451007769	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
715451007770	Walker A/P-loop; other site
715451007771	ATP binding site [chemical binding]; other site
715451007772	Q-loop/lid; other site
715451007773	ABC transporter signature motif; other site
715451007774	Walker B; other site
715451007775	D-loop; other site
715451007776	H-loop/switch region; other site
715451007777	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
715451007778	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
715451007779	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
715451007780	ligand binding site [chemical binding]; other site
715451007781	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
715451007782	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
715451007783	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
715451007784	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
715451007785	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
715451007786	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
715451007787	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
715451007788	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
715451007789	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
715451007790	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
715451007791	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
715451007792	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
715451007793	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
715451007794	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
715451007795	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
715451007796	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
715451007797	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
715451007798	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
715451007799	Smr domain; Region: Smr; pfam01713
715451007800	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
715451007801	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
715451007802	dimerization interface [polypeptide binding]; other site
715451007803	ATP binding site [chemical binding]; other site
715451007804	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
715451007805	dimerization interface [polypeptide binding]; other site
715451007806	ATP binding site [chemical binding]; other site
715451007807	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
715451007808	putative active site [active]
715451007809	catalytic triad [active]
715451007810	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
715451007811	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
715451007812	substrate binding pocket [chemical binding]; other site
715451007813	membrane-bound complex binding site; other site
715451007814	hinge residues; other site
715451007815	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
715451007816	N-acetyl-D-glucosamine binding site [chemical binding]; other site
715451007817	catalytic residue [active]
715451007818	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
715451007819	nucleoside/Zn binding site; other site
715451007820	dimer interface [polypeptide binding]; other site
715451007821	catalytic motif [active]
715451007822	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
715451007823	putative cation:proton antiport protein; Provisional; Region: PRK10669
715451007824	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
715451007825	TrkA-N domain; Region: TrkA_N; pfam02254
715451007826	TrkA-C domain; Region: TrkA_C; pfam02080
715451007827	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451007828	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451007829	metal binding site [ion binding]; metal-binding site
715451007830	active site
715451007831	I-site; other site
715451007832	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
715451007833	Ligand Binding Site [chemical binding]; other site
715451007834	TilS substrate binding domain; Region: TilS; pfam09179
715451007835	TilS substrate C-terminal domain; Region: TilS_C; smart00977
715451007836	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
715451007837	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
715451007838	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
715451007839	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
715451007840	putative active site [active]
715451007841	putative PHP Thumb interface [polypeptide binding]; other site
715451007842	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
715451007843	generic binding surface I; other site
715451007844	generic binding surface II; other site
715451007845	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
715451007846	RNA/DNA hybrid binding site [nucleotide binding]; other site
715451007847	active site
715451007848	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
715451007849	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
715451007850	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
715451007851	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
715451007852	active site
715451007853	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
715451007854	periplasmic chaperone; Provisional; Region: PRK10780
715451007855	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
715451007856	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
715451007857	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
715451007858	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
715451007859	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
715451007860	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
715451007861	Surface antigen; Region: Bac_surface_Ag; pfam01103
715451007862	zinc metallopeptidase RseP; Provisional; Region: PRK10779
715451007863	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
715451007864	active site
715451007865	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
715451007866	protein binding site [polypeptide binding]; other site
715451007867	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
715451007868	protein binding site [polypeptide binding]; other site
715451007869	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
715451007870	putative substrate binding region [chemical binding]; other site
715451007871	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
715451007872	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
715451007873	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
715451007874	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
715451007875	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
715451007876	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
715451007877	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
715451007878	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
715451007879	catalytic residue [active]
715451007880	putative FPP diphosphate  binding site; other site
715451007881	putative FPP binding hydrophobic cleft; other site
715451007882	dimer interface [polypeptide binding]; other site
715451007883	putative IPP diphosphate binding site; other site
715451007884	ribosome recycling factor; Reviewed; Region: frr; PRK00083
715451007885	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
715451007886	hinge region; other site
715451007887	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
715451007888	putative nucleotide binding site [chemical binding]; other site
715451007889	uridine monophosphate binding site [chemical binding]; other site
715451007890	homohexameric interface [polypeptide binding]; other site
715451007891	elongation factor Ts; Provisional; Region: tsf; PRK09377
715451007892	UBA/TS-N domain; Region: UBA; pfam00627
715451007893	Elongation factor TS; Region: EF_TS; pfam00889
715451007894	Elongation factor TS; Region: EF_TS; pfam00889
715451007895	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
715451007896	rRNA interaction site [nucleotide binding]; other site
715451007897	S8 interaction site; other site
715451007898	putative laminin-1 binding site; other site
715451007899	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
715451007900	active site
715451007901	PII uridylyl-transferase; Provisional; Region: PRK05007
715451007902	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
715451007903	metal binding triad; other site
715451007904	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
715451007905	HD domain; Region: HD; pfam01966
715451007906	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
715451007907	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
715451007908	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
715451007909	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
715451007910	trimer interface [polypeptide binding]; other site
715451007911	active site
715451007912	substrate binding site [chemical binding]; other site
715451007913	CoA binding site [chemical binding]; other site
715451007914	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
715451007915	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
715451007916	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
715451007917	probable active site [active]
715451007918	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
715451007919	Protein of unknown function (DUF3549); Region: DUF3549; pfam12069
715451007920	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
715451007921	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
715451007922	Catalytic site [active]
715451007923	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
715451007924	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
715451007925	active site
715451007926	DNA binding site [nucleotide binding]
715451007927	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
715451007928	Uncharacterized conserved protein [Function unknown]; Region: COG3791
715451007929	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
715451007930	Coenzyme A binding pocket [chemical binding]; other site
715451007931	Protein of unknown function (DUF3192); Region: DUF3192; pfam11399
715451007932	Syd protein (SUKH-2); Region: Syd; pfam07348
715451007933	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
715451007934	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
715451007935	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
715451007936	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451007937	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451007938	metal binding site [ion binding]; metal-binding site
715451007939	active site
715451007940	I-site; other site
715451007941	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
715451007942	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
715451007943	Protein of unknown function (DUF3192); Region: DUF3192; pfam11399
715451007944	tartrate dehydrogenase; Region: TTC; TIGR02089
715451007945	isocitrate dehydrogenase; Provisional; Region: PRK08997
715451007946	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
715451007947	Helix-hairpin-helix motif; Region: HHH; pfam00633
715451007948	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
715451007949	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
715451007950	active site
715451007951	tetramer interface; other site
715451007952	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
715451007953	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
715451007954	Ligand binding site; other site
715451007955	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
715451007956	active site
715451007957	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
715451007958	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
715451007959	Mg++ binding site [ion binding]; other site
715451007960	putative catalytic motif [active]
715451007961	substrate binding site [chemical binding]; other site
715451007962	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
715451007963	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
715451007964	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
715451007965	ABC-2 type transporter; Region: ABC2_membrane; cl17235
715451007966	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
715451007967	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
715451007968	Walker A/P-loop; other site
715451007969	ATP binding site [chemical binding]; other site
715451007970	Q-loop/lid; other site
715451007971	ABC transporter signature motif; other site
715451007972	Walker B; other site
715451007973	D-loop; other site
715451007974	H-loop/switch region; other site
715451007975	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
715451007976	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
715451007977	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451007978	putative substrate translocation pore; other site
715451007979	POT family; Region: PTR2; cl17359
715451007980	UDP-glucose 4-epimerase; Region: PLN02240
715451007981	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
715451007982	NAD binding site [chemical binding]; other site
715451007983	homodimer interface [polypeptide binding]; other site
715451007984	active site
715451007985	substrate binding site [chemical binding]; other site
715451007986	VacJ like lipoprotein; Region: VacJ; cl01073
715451007987	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451007988	binding surface
715451007989	TPR motif; other site
715451007990	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
715451007991	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
715451007992	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
715451007993	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
715451007994	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
715451007995	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
715451007996	heme exporter protein CcmC; Region: ccmC; TIGR01191
715451007997	heme exporter protein CcmB; Region: ccmB; TIGR01190
715451007998	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
715451007999	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451008000	Walker A/P-loop; other site
715451008001	ATP binding site [chemical binding]; other site
715451008002	Q-loop/lid; other site
715451008003	ABC transporter signature motif; other site
715451008004	Walker B; other site
715451008005	D-loop; other site
715451008006	H-loop/switch region; other site
715451008007	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
715451008008	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
715451008009	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
715451008010	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
715451008011	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
715451008012	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451008013	Walker A/P-loop; other site
715451008014	ATP binding site [chemical binding]; other site
715451008015	Q-loop/lid; other site
715451008016	ABC transporter signature motif; other site
715451008017	Walker B; other site
715451008018	D-loop; other site
715451008019	H-loop/switch region; other site
715451008020	recombinase A; Provisional; Region: recA; PRK09354
715451008021	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
715451008022	hexamer interface [polypeptide binding]; other site
715451008023	Walker A motif; other site
715451008024	ATP binding site [chemical binding]; other site
715451008025	Walker B motif; other site
715451008026	Competence-damaged protein; Region: CinA; pfam02464
715451008027	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
715451008028	MutS domain I; Region: MutS_I; pfam01624
715451008029	MutS domain II; Region: MutS_II; pfam05188
715451008030	MutS domain III; Region: MutS_III; pfam05192
715451008031	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
715451008032	Walker A/P-loop; other site
715451008033	ATP binding site [chemical binding]; other site
715451008034	Q-loop/lid; other site
715451008035	ABC transporter signature motif; other site
715451008036	Walker B; other site
715451008037	D-loop; other site
715451008038	H-loop/switch region; other site
715451008039	CTP synthetase; Validated; Region: pyrG; PRK05380
715451008040	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
715451008041	Catalytic site [active]
715451008042	active site
715451008043	UTP binding site [chemical binding]; other site
715451008044	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
715451008045	active site
715451008046	putative oxyanion hole; other site
715451008047	catalytic triad [active]
715451008048	enolase; Provisional; Region: eno; PRK00077
715451008049	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
715451008050	dimer interface [polypeptide binding]; other site
715451008051	metal binding site [ion binding]; metal-binding site
715451008052	substrate binding pocket [chemical binding]; other site
715451008053	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
715451008054	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451008055	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451008056	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
715451008057	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
715451008058	2-isopropylmalate synthase; Validated; Region: PRK00915
715451008059	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
715451008060	active site
715451008061	catalytic residues [active]
715451008062	metal binding site [ion binding]; metal-binding site
715451008063	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
715451008064	tartrate dehydrogenase; Region: TTC; TIGR02089
715451008065	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
715451008066	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
715451008067	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
715451008068	substrate binding site [chemical binding]; other site
715451008069	ligand binding site [chemical binding]; other site
715451008070	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
715451008071	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
715451008072	substrate binding site [chemical binding]; other site
715451008073	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
715451008074	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
715451008075	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
715451008076	Zn2+ binding site [ion binding]; other site
715451008077	Mg2+ binding site [ion binding]; other site
715451008078	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
715451008079	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
715451008080	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
715451008081	Walker A motif; other site
715451008082	ATP binding site [chemical binding]; other site
715451008083	Walker B motif; other site
715451008084	arginine finger; other site
715451008085	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
715451008086	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
715451008087	active site
715451008088	NTP binding site [chemical binding]; other site
715451008089	metal binding triad [ion binding]; metal-binding site
715451008090	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
715451008091	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
715451008092	DEAD-like helicases superfamily; Region: DEXDc; smart00487
715451008093	ATP binding site [chemical binding]; other site
715451008094	Mg++ binding site [ion binding]; other site
715451008095	motif III; other site
715451008096	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451008097	nucleotide binding region [chemical binding]; other site
715451008098	ATP-binding site [chemical binding]; other site
715451008099	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
715451008100	active site
715451008101	dimerization interface [polypeptide binding]; other site
715451008102	HemN family oxidoreductase; Provisional; Region: PRK05660
715451008103	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
715451008104	FeS/SAM binding site; other site
715451008105	HemN C-terminal domain; Region: HemN_C; pfam06969
715451008106	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
715451008107	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
715451008108	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
715451008109	PAS domain; Region: PAS; smart00091
715451008110	PAS fold; Region: PAS; pfam00989
715451008111	putative active site [active]
715451008112	heme pocket [chemical binding]; other site
715451008113	Response regulator receiver domain; Region: Response_reg; pfam00072
715451008114	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451008115	active site
715451008116	phosphorylation site [posttranslational modification]
715451008117	intermolecular recognition site; other site
715451008118	dimerization interface [polypeptide binding]; other site
715451008119	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
715451008120	LrgB-like family; Region: LrgB; pfam04172
715451008121	LrgA family; Region: LrgA; cl00608
715451008122	Protein of unknown function (DUF3718); Region: DUF3718; pfam12514
715451008123	AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052
715451008124	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
715451008125	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
715451008126	ATP binding site [chemical binding]; other site
715451008127	putative Mg++ binding site [ion binding]; other site
715451008128	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451008129	nucleotide binding region [chemical binding]; other site
715451008130	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
715451008131	AAA ATPase domain; Region: AAA_16; pfam13191
715451008132	Domain of unknown function (DUF4016); Region: DUF4016; pfam13208
715451008133	tellurite resistance protein terB; Region: terB; cd07176
715451008134	putative metal binding site [ion binding]; other site
715451008135	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
715451008136	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
715451008137	potential frameshift: common BLAST hit: gi|290474585|ref|YP_003467465.1| putative transposase
715451008138	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
715451008139	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
715451008140	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
715451008141	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
715451008142	ATP binding site [chemical binding]; other site
715451008143	putative Mg++ binding site [ion binding]; other site
715451008144	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451008145	nucleotide binding region [chemical binding]; other site
715451008146	ATP-binding site [chemical binding]; other site
715451008147	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
715451008148	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
715451008149	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
715451008150	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451008151	conserved hypothetical protein; Region: TIGR02285
715451008152	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
715451008153	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
715451008154	active site
715451008155	nucleophile elbow; other site
715451008156	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
715451008157	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
715451008158	Transposase [DNA replication, recombination, and repair]; Region: COG5433
715451008159	Transposase [DNA replication, recombination, and repair]; Region: COG5433
715451008160	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
715451008161	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451008162	Walker A/P-loop; other site
715451008163	ATP binding site [chemical binding]; other site
715451008164	Q-loop/lid; other site
715451008165	ABC transporter signature motif; other site
715451008166	Walker B; other site
715451008167	D-loop; other site
715451008168	H-loop/switch region; other site
715451008169	ABC transporter; Region: ABC_tran_2; pfam12848
715451008170	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
715451008171	patatin-related protein; Region: TIGR03607
715451008172	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
715451008173	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
715451008174	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
715451008175	active site
715451008176	dimer interface [polypeptide binding]; other site
715451008177	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
715451008178	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
715451008179	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
715451008180	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451008181	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451008182	metal binding site [ion binding]; metal-binding site
715451008183	active site
715451008184	I-site; other site
715451008185	exonuclease subunit SbcC; Provisional; Region: PRK10246
715451008186	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451008187	Walker A/P-loop; other site
715451008188	ATP binding site [chemical binding]; other site
715451008189	Q-loop/lid; other site
715451008190	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451008191	ABC transporter signature motif; other site
715451008192	Walker B; other site
715451008193	D-loop; other site
715451008194	H-loop/switch region; other site
715451008195	exonuclease subunit SbcD; Provisional; Region: PRK10966
715451008196	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
715451008197	active site
715451008198	metal binding site [ion binding]; metal-binding site
715451008199	DNA binding site [nucleotide binding]
715451008200	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
715451008201	PAS domain; Region: PAS_9; pfam13426
715451008202	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451008203	PAS domain; Region: PAS_9; pfam13426
715451008204	putative active site [active]
715451008205	heme pocket [chemical binding]; other site
715451008206	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
715451008207	dimer interface [polypeptide binding]; other site
715451008208	putative CheW interface [polypeptide binding]; other site
715451008209	hypothetical protein; Provisional; Region: PRK11568
715451008210	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
715451008211	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
715451008212	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
715451008213	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
715451008214	putative catalytic residues [active]
715451008215	leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411
715451008216	Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599
715451008217	active site
715451008218	Zn binding site [ion binding]; other site
715451008219	Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127
715451008220	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
715451008221	Transcriptional regulators [Transcription]; Region: MarR; COG1846
715451008222	MarR family; Region: MarR_2; cl17246
715451008223	PAS domain S-box; Region: sensory_box; TIGR00229
715451008224	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451008225	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451008226	metal binding site [ion binding]; metal-binding site
715451008227	active site
715451008228	I-site; other site
715451008229	Haemolysin-III related; Region: HlyIII; cl03831
715451008230	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
715451008231	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
715451008232	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451008233	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
715451008234	DNA binding residues [nucleotide binding]
715451008235	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
715451008236	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451008237	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
715451008238	dimerization interface [polypeptide binding]; other site
715451008239	universal stress protein UspE; Provisional; Region: PRK11175
715451008240	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
715451008241	Ligand Binding Site [chemical binding]; other site
715451008242	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
715451008243	Ligand Binding Site [chemical binding]; other site
715451008244	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
715451008245	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
715451008246	transcriptional regulator PhoU; Provisional; Region: PRK11115
715451008247	PhoU domain; Region: PhoU; pfam01895
715451008248	PhoU domain; Region: PhoU; pfam01895
715451008249	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
715451008250	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
715451008251	Walker A/P-loop; other site
715451008252	ATP binding site [chemical binding]; other site
715451008253	Q-loop/lid; other site
715451008254	ABC transporter signature motif; other site
715451008255	Walker B; other site
715451008256	D-loop; other site
715451008257	H-loop/switch region; other site
715451008258	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
715451008259	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
715451008260	dimer interface [polypeptide binding]; other site
715451008261	conserved gate region; other site
715451008262	putative PBP binding loops; other site
715451008263	ABC-ATPase subunit interface; other site
715451008264	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
715451008265	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
715451008266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
715451008267	dimer interface [polypeptide binding]; other site
715451008268	conserved gate region; other site
715451008269	putative PBP binding loops; other site
715451008270	ABC-ATPase subunit interface; other site
715451008271	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
715451008272	ACT domain; Region: ACT_6; pfam13740
715451008273	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
715451008274	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
715451008275	polyphosphate kinase 1; Region: poly_P_kin; TIGR03705
715451008276	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
715451008277	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
715451008278	domain interface [polypeptide binding]; other site
715451008279	active site
715451008280	catalytic site [active]
715451008281	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
715451008282	domain interface [polypeptide binding]; other site
715451008283	active site
715451008284	catalytic site [active]
715451008285	exopolyphosphatase; Provisional; Region: PRK10854
715451008286	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
715451008287	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
715451008288	catalytic residue [active]
715451008289	Phosphoglycerate kinase; Region: PGK; pfam00162
715451008290	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
715451008291	substrate binding site [chemical binding]; other site
715451008292	hinge regions; other site
715451008293	ADP binding site [chemical binding]; other site
715451008294	catalytic site [active]
715451008295	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
715451008296	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
715451008297	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
715451008298	transketolase; Reviewed; Region: PRK12753
715451008299	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
715451008300	TPP-binding site [chemical binding]; other site
715451008301	dimer interface [polypeptide binding]; other site
715451008302	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
715451008303	PYR/PP interface [polypeptide binding]; other site
715451008304	dimer interface [polypeptide binding]; other site
715451008305	TPP binding site [chemical binding]; other site
715451008306	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
715451008307	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
715451008308	S-adenosylmethionine synthetase; Validated; Region: PRK05250
715451008309	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
715451008310	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
715451008311	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
715451008312	putative active site; other site
715451008313	putative metal binding residues [ion binding]; other site
715451008314	signature motif; other site
715451008315	putative triphosphate binding site [ion binding]; other site
715451008316	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
715451008317	active site
715451008318	catalytic site [active]
715451008319	substrate binding site [chemical binding]; other site
715451008320	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
715451008321	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
715451008322	dimer interface [polypeptide binding]; other site
715451008323	active site
715451008324	metal binding site [ion binding]; metal-binding site
715451008325	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
715451008326	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
715451008327	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
715451008328	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
715451008329	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
715451008330	putative ligand binding site [chemical binding]; other site
715451008331	PAS domain; Region: PAS_9; pfam13426
715451008332	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451008333	putative active site [active]
715451008334	heme pocket [chemical binding]; other site
715451008335	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451008336	dimer interface [polypeptide binding]; other site
715451008337	phosphorylation site [posttranslational modification]
715451008338	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451008339	ATP binding site [chemical binding]; other site
715451008340	Mg2+ binding site [ion binding]; other site
715451008341	G-X-G motif; other site
715451008342	Response regulator receiver domain; Region: Response_reg; pfam00072
715451008343	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451008344	active site
715451008345	phosphorylation site [posttranslational modification]
715451008346	intermolecular recognition site; other site
715451008347	dimerization interface [polypeptide binding]; other site
715451008348	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451008349	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451008350	metal binding site [ion binding]; metal-binding site
715451008351	active site
715451008352	I-site; other site
715451008353	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451008354	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
715451008355	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
715451008356	TrkA-C domain; Region: TrkA_C; pfam02080
715451008357	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
715451008358	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
715451008359	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
715451008360	Protein export membrane protein; Region: SecD_SecF; cl14618
715451008361	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
715451008362	dinuclear metal binding motif [ion binding]; other site
715451008363	Predicted membrane protein [Function unknown]; Region: COG2323
715451008364	Helix-turn-helix domain; Region: HTH_18; pfam12833
715451008365	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
715451008366	putative transposase OrfB; Reviewed; Region: PHA02517
715451008367	HTH-like domain; Region: HTH_21; pfam13276
715451008368	Integrase core domain; Region: rve; pfam00665
715451008369	Integrase core domain; Region: rve_3; pfam13683
715451008370	Transposase; Region: HTH_Tnp_1; pfam01527
715451008371	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
715451008372	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
715451008373	tellurium resistance terB-like protein; Region: terB_like; cd07177
715451008374	metal binding site [ion binding]; metal-binding site
715451008375	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
715451008376	HSP70 interaction site [polypeptide binding]; other site
715451008377	hypothetical protein; Provisional; Region: PRK12378
715451008378	Predicted ATPase [General function prediction only]; Region: COG1485
715451008379	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
715451008380	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
715451008381	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
715451008382	protein binding site [polypeptide binding]; other site
715451008383	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
715451008384	protein binding site [polypeptide binding]; other site
715451008385	serine endoprotease; Provisional; Region: PRK10898
715451008386	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
715451008387	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
715451008388	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
715451008389	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
715451008390	hinge; other site
715451008391	active site
715451008392	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
715451008393	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
715451008394	anti sigma factor interaction site; other site
715451008395	regulatory phosphorylation site [posttranslational modification]; other site
715451008396	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
715451008397	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
715451008398	mce related protein; Region: MCE; pfam02470
715451008399	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
715451008400	Permease; Region: Permease; cl00510
715451008401	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
715451008402	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
715451008403	Walker A/P-loop; other site
715451008404	ATP binding site [chemical binding]; other site
715451008405	Q-loop/lid; other site
715451008406	ABC transporter signature motif; other site
715451008407	Walker B; other site
715451008408	D-loop; other site
715451008409	H-loop/switch region; other site
715451008410	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
715451008411	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
715451008412	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
715451008413	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
715451008414	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
715451008415	putative active site [active]
715451008416	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
715451008417	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
715451008418	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
715451008419	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
715451008420	OstA-like protein; Region: OstA; cl00844
715451008421	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
715451008422	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
715451008423	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
715451008424	Walker A/P-loop; other site
715451008425	ATP binding site [chemical binding]; other site
715451008426	Q-loop/lid; other site
715451008427	ABC transporter signature motif; other site
715451008428	Walker B; other site
715451008429	D-loop; other site
715451008430	H-loop/switch region; other site
715451008431	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
715451008432	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
715451008433	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
715451008434	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
715451008435	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
715451008436	30S subunit binding site; other site
715451008437	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
715451008438	active site
715451008439	phosphorylation site [posttranslational modification]
715451008440	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
715451008441	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
715451008442	dimerization domain swap beta strand [polypeptide binding]; other site
715451008443	regulatory protein interface [polypeptide binding]; other site
715451008444	active site
715451008445	regulatory phosphorylation site [posttranslational modification]; other site
715451008446	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
715451008447	MgtE intracellular N domain; Region: MgtE_N; smart00924
715451008448	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
715451008449	Divalent cation transporter; Region: MgtE; pfam01769
715451008450	potential frameshift: common BLAST hit: gi|242278756|ref|YP_002990885.1| CheW protein
715451008451	potential frameshift: common BLAST hit: gi|109899285|ref|YP_662540.1| AraC family transcriptional regulator
715451008452	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
715451008453	stringent starvation protein A; Provisional; Region: sspA; PRK09481
715451008454	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
715451008455	C-terminal domain interface [polypeptide binding]; other site
715451008456	putative GSH binding site (G-site) [chemical binding]; other site
715451008457	dimer interface [polypeptide binding]; other site
715451008458	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
715451008459	dimer interface [polypeptide binding]; other site
715451008460	N-terminal domain interface [polypeptide binding]; other site
715451008461	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
715451008462	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
715451008463	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
715451008464	Qi binding site; other site
715451008465	intrachain domain interface; other site
715451008466	interchain domain interface [polypeptide binding]; other site
715451008467	heme bH binding site [chemical binding]; other site
715451008468	heme bL binding site [chemical binding]; other site
715451008469	Qo binding site; other site
715451008470	interchain domain interface [polypeptide binding]; other site
715451008471	intrachain domain interface; other site
715451008472	Qi binding site; other site
715451008473	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
715451008474	Qo binding site; other site
715451008475	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
715451008476	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
715451008477	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
715451008478	[2Fe-2S] cluster binding site [ion binding]; other site
715451008479	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
715451008480	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
715451008481	putative metal binding site [ion binding]; other site
715451008482	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
715451008483	active site
715451008484	Zn binding site [ion binding]; other site
715451008485	Secretin and TonB N terminus short domain; Region: STN; smart00965
715451008486	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451008487	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451008488	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451008489	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
715451008490	FecR protein; Region: FecR; pfam04773
715451008491	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
715451008492	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451008493	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
715451008494	DNA binding residues [nucleotide binding]
715451008495	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
715451008496	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
715451008497	23S rRNA interface [nucleotide binding]; other site
715451008498	L3 interface [polypeptide binding]; other site
715451008499	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
715451008500	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
715451008501	TPR motif; other site
715451008502	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
715451008503	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
715451008504	homodimer interface [polypeptide binding]; other site
715451008505	metal binding site [ion binding]; metal-binding site
715451008506	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
715451008507	homodimer interface [polypeptide binding]; other site
715451008508	active site
715451008509	putative chemical substrate binding site [chemical binding]; other site
715451008510	metal binding site [ion binding]; metal-binding site
715451008511	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
715451008512	HD domain; Region: HD_4; pfam13328
715451008513	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
715451008514	synthetase active site [active]
715451008515	NTP binding site [chemical binding]; other site
715451008516	metal binding site [ion binding]; metal-binding site
715451008517	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
715451008518	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
715451008519	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
715451008520	TRAM domain; Region: TRAM; cl01282
715451008521	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451008522	S-adenosylmethionine binding site [chemical binding]; other site
715451008523	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
715451008524	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
715451008525	active site
715451008526	hydrophilic channel; other site
715451008527	dimerization interface [polypeptide binding]; other site
715451008528	catalytic residues [active]
715451008529	active site lid [active]
715451008530	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
715451008531	Recombination protein O N terminal; Region: RecO_N; pfam11967
715451008532	Recombination protein O C terminal; Region: RecO_C; pfam02565
715451008533	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
715451008534	DHH family; Region: DHH; pfam01368
715451008535	DHHA1 domain; Region: DHHA1; pfam02272
715451008536	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
715451008537	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
715451008538	dimerization domain [polypeptide binding]; other site
715451008539	dimer interface [polypeptide binding]; other site
715451008540	catalytic residues [active]
715451008541	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
715451008542	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
715451008543	active site
715451008544	Int/Topo IB signature motif; other site
715451008545	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
715451008546	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
715451008547	putative metal binding site [ion binding]; other site
715451008548	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
715451008549	HSP70 interaction site [polypeptide binding]; other site
715451008550	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
715451008551	Organic solvent tolerance protein; Region: OstA_C; pfam04453
715451008552	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
715451008553	SurA N-terminal domain; Region: SurA_N; pfam09312
715451008554	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
715451008555	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
715451008556	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
715451008557	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
715451008558	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
715451008559	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
715451008560	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
715451008561	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
715451008562	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
715451008563	active site
715451008564	metal binding site [ion binding]; metal-binding site
715451008565	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
715451008566	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
715451008567	dimerization interface [polypeptide binding]; other site
715451008568	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
715451008569	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
715451008570	dimer interface [polypeptide binding]; other site
715451008571	putative CheW interface [polypeptide binding]; other site
715451008572	aspartate kinase III; Validated; Region: PRK09084
715451008573	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
715451008574	nucleotide binding site [chemical binding]; other site
715451008575	substrate binding site [chemical binding]; other site
715451008576	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932
715451008577	lysine allosteric regulatory site; other site
715451008578	dimer interface [polypeptide binding]; other site
715451008579	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
715451008580	dimer interface [polypeptide binding]; other site
715451008581	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
715451008582	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
715451008583	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
715451008584	substrate binding site [chemical binding]; other site
715451008585	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
715451008586	substrate binding site [chemical binding]; other site
715451008587	ligand binding site [chemical binding]; other site
715451008588	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
715451008589	DNA binding site [nucleotide binding]
715451008590	active site
715451008591	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
715451008592	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
715451008593	DNA binding site [nucleotide binding]
715451008594	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
715451008595	Aconitate hydratase 2 N-terminus; Region: Aconitase_2_N; pfam06434
715451008596	substrate binding site [chemical binding]; other site
715451008597	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
715451008598	substrate binding site [chemical binding]; other site
715451008599	ligand binding site [chemical binding]; other site
715451008600	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
715451008601	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
715451008602	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
715451008603	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
715451008604	acyl-activating enzyme (AAE) consensus motif; other site
715451008605	putative AMP binding site [chemical binding]; other site
715451008606	putative active site [active]
715451008607	putative CoA binding site [chemical binding]; other site
715451008608	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451008609	PAS domain; Region: PAS_9; pfam13426
715451008610	putative active site [active]
715451008611	heme pocket [chemical binding]; other site
715451008612	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
715451008613	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451008614	putative active site [active]
715451008615	heme pocket [chemical binding]; other site
715451008616	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451008617	dimer interface [polypeptide binding]; other site
715451008618	phosphorylation site [posttranslational modification]
715451008619	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451008620	ATP binding site [chemical binding]; other site
715451008621	Mg2+ binding site [ion binding]; other site
715451008622	G-X-G motif; other site
715451008623	Response regulator receiver domain; Region: Response_reg; pfam00072
715451008624	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451008625	active site
715451008626	phosphorylation site [posttranslational modification]
715451008627	intermolecular recognition site; other site
715451008628	dimerization interface [polypeptide binding]; other site
715451008629	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
715451008630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451008631	active site
715451008632	phosphorylation site [posttranslational modification]
715451008633	intermolecular recognition site; other site
715451008634	dimerization interface [polypeptide binding]; other site
715451008635	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
715451008636	Zn2+ binding site [ion binding]; other site
715451008637	Mg2+ binding site [ion binding]; other site
715451008638	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
715451008639	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
715451008640	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
715451008641	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
715451008642	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
715451008643	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
715451008644	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
715451008645	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
715451008646	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451008647	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451008648	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
715451008649	PBP superfamily domain; Region: PBP_like_2; cl17296
715451008650	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
715451008651	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
715451008652	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451008653	dimer interface [polypeptide binding]; other site
715451008654	phosphorylation site [posttranslational modification]
715451008655	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451008656	ATP binding site [chemical binding]; other site
715451008657	Mg2+ binding site [ion binding]; other site
715451008658	G-X-G motif; other site
715451008659	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
715451008660	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451008661	active site
715451008662	phosphorylation site [posttranslational modification]
715451008663	intermolecular recognition site; other site
715451008664	dimerization interface [polypeptide binding]; other site
715451008665	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451008666	DNA binding site [nucleotide binding]
715451008667	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451008668	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451008669	ATP binding site [chemical binding]; other site
715451008670	Mg2+ binding site [ion binding]; other site
715451008671	G-X-G motif; other site
715451008672	recombination associated protein; Reviewed; Region: rdgC; PRK00321
715451008673	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
715451008674	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
715451008675	non-specific DNA binding site [nucleotide binding]; other site
715451008676	salt bridge; other site
715451008677	sequence-specific DNA binding site [nucleotide binding]; other site
715451008678	Cupin domain; Region: Cupin_2; pfam07883
715451008679	Benzoate membrane transport protein; Region: BenE; pfam03594
715451008680	benzoate transporter; Region: benE; TIGR00843
715451008681	HDOD domain; Region: HDOD; pfam08668
715451008682	Nudix hydrolase homolog; Region: PLN02791
715451008683	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
715451008684	nucleotide binding site/active site [active]
715451008685	HIT family signature motif; other site
715451008686	catalytic residue [active]
715451008687	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
715451008688	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism]; Region: FolK; COG0801
715451008689	catalytic center binding site [active]
715451008690	ATP binding site [chemical binding]; other site
715451008691	Dihydroneopterin aldolase; Region: FolB; pfam02152
715451008692	active site
715451008693	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
715451008694	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
715451008695	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
715451008696	UGMP family protein; Validated; Region: PRK09604
715451008697	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
715451008698	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
715451008699	Yqey-like protein; Region: YqeY; pfam09424
715451008700	DNA primase; Validated; Region: dnaG; PRK05667
715451008701	CHC2 zinc finger; Region: zf-CHC2; pfam01807
715451008702	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
715451008703	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
715451008704	active site
715451008705	metal binding site [ion binding]; metal-binding site
715451008706	interdomain interaction site; other site
715451008707	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
715451008708	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
715451008709	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
715451008710	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
715451008711	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
715451008712	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
715451008713	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451008714	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
715451008715	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
715451008716	DNA binding residues [nucleotide binding]
715451008717	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
715451008718	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
715451008719	dimerization interface [polypeptide binding]; other site
715451008720	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
715451008721	dimer interface [polypeptide binding]; other site
715451008722	putative CheW interface [polypeptide binding]; other site
715451008723	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
715451008724	Protein export membrane protein; Region: SecD_SecF; cl14618
715451008725	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
715451008726	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
715451008727	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451008728	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
715451008729	nudix motif; other site
715451008730	aldolase II superfamily protein; Provisional; Region: PRK07044
715451008731	active site
715451008732	intersubunit interface [polypeptide binding]; other site
715451008733	Zn2+ binding site [ion binding]; other site
715451008734	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
715451008735	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
715451008736	active site pocket [active]
715451008737	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
715451008738	Amidohydrolase; Region: Amidohydro_2; pfam04909
715451008739	aldose dehydrogenase; Validated; Region: PRK06398
715451008740	classical (c) SDRs; Region: SDR_c; cd05233
715451008741	NAD(P) binding site [chemical binding]; other site
715451008742	active site
715451008743	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
715451008744	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
715451008745	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
715451008746	active site
715451008747	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
715451008748	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
715451008749	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
715451008750	4Fe-4S binding domain; Region: Fer4_5; pfam12801
715451008751	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
715451008752	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
715451008753	serine/threonine protein kinase; Provisional; Region: PRK11768
715451008754	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
715451008755	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
715451008756	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451008757	N-terminal plug; other site
715451008758	ligand-binding site [chemical binding]; other site
715451008759	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
715451008760	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
715451008761	catalytic residues [active]
715451008762	hinge region; other site
715451008763	alpha helical domain; other site
715451008764	HD domain; Region: HD_3; pfam13023
715451008765	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
715451008766	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
715451008767	Walker A/P-loop; other site
715451008768	ATP binding site [chemical binding]; other site
715451008769	Q-loop/lid; other site
715451008770	ABC transporter signature motif; other site
715451008771	Walker B; other site
715451008772	D-loop; other site
715451008773	H-loop/switch region; other site
715451008774	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
715451008775	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
715451008776	dimer interface [polypeptide binding]; other site
715451008777	conserved gate region; other site
715451008778	putative PBP binding loops; other site
715451008779	ABC-ATPase subunit interface; other site
715451008780	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
715451008781	NMT1-like family; Region: NMT1_2; pfam13379
715451008782	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451008783	PAS domain; Region: PAS_9; pfam13426
715451008784	putative active site [active]
715451008785	heme pocket [chemical binding]; other site
715451008786	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451008787	PAS domain; Region: PAS_9; pfam13426
715451008788	putative active site [active]
715451008789	heme pocket [chemical binding]; other site
715451008790	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
715451008791	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
715451008792	dimer interface [polypeptide binding]; other site
715451008793	putative CheW interface [polypeptide binding]; other site
715451008794	hypothetical protein; Validated; Region: PRK09071
715451008795	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
715451008796	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
715451008797	active site
715451008798	SAM binding site [chemical binding]; other site
715451008799	homodimer interface [polypeptide binding]; other site
715451008800	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
715451008801	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
715451008802	[4Fe-4S] binding site [ion binding]; other site
715451008803	molybdopterin cofactor binding site; other site
715451008804	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
715451008805	molybdopterin cofactor binding site; other site
715451008806	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
715451008807	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
715451008808	nitrite reductase subunit NirD; Provisional; Region: PRK14989
715451008809	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
715451008810	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
715451008811	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
715451008812	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
715451008813	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
715451008814	Sulfate transporter family; Region: Sulfate_transp; pfam00916
715451008815	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
715451008816	Nitrate and nitrite sensing; Region: NIT; pfam08376
715451008817	ANTAR domain; Region: ANTAR; pfam03861
715451008818	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
715451008819	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
715451008820	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
715451008821	active site
715451008822	BolA-like protein; Region: BolA; cl00386
715451008823	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
715451008824	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
715451008825	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451008826	S-adenosylmethionine binding site [chemical binding]; other site
715451008827	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
715451008828	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
715451008829	active site
715451008830	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
715451008831	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
715451008832	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
715451008833	putative active site pocket [active]
715451008834	dimerization interface [polypeptide binding]; other site
715451008835	putative catalytic residue [active]
715451008836	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
715451008837	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451008838	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451008839	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
715451008840	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
715451008841	motif 1; other site
715451008842	dimer interface [polypeptide binding]; other site
715451008843	active site
715451008844	motif 2; other site
715451008845	motif 3; other site
715451008846	elongation factor P; Validated; Region: PRK00529
715451008847	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
715451008848	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
715451008849	RNA binding site [nucleotide binding]; other site
715451008850	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
715451008851	RNA binding site [nucleotide binding]; other site
715451008852	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
715451008853	Radical SAM superfamily; Region: Radical_SAM; pfam04055
715451008854	FeS/SAM binding site; other site
715451008855	Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; pfam10043
715451008856	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
715451008857	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
715451008858	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
715451008859	motif II; other site
715451008860	PAS fold; Region: PAS_2; pfam08446
715451008861	GAF domain; Region: GAF; pfam01590
715451008862	Phytochrome region; Region: PHY; pfam00360
715451008863	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
715451008864	CheB methylesterase; Region: CheB_methylest; pfam01339
715451008865	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
715451008866	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
715451008867	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
715451008868	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
715451008869	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
715451008870	putative active site [active]
715451008871	catalytic site [active]
715451008872	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451008873	putative active site [active]
715451008874	heme pocket [chemical binding]; other site
715451008875	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451008876	PAS domain; Region: PAS_9; pfam13426
715451008877	putative active site [active]
715451008878	heme pocket [chemical binding]; other site
715451008879	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451008880	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451008881	metal binding site [ion binding]; metal-binding site
715451008882	active site
715451008883	I-site; other site
715451008884	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451008885	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
715451008886	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451008887	ATP binding site [chemical binding]; other site
715451008888	Mg2+ binding site [ion binding]; other site
715451008889	G-X-G motif; other site
715451008890	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
715451008891	anchoring element; other site
715451008892	dimer interface [polypeptide binding]; other site
715451008893	ATP binding site [chemical binding]; other site
715451008894	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
715451008895	active site
715451008896	metal binding site [ion binding]; metal-binding site
715451008897	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
715451008898	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
715451008899	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
715451008900	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
715451008901	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
715451008902	active site
715451008903	metal binding site [ion binding]; metal-binding site
715451008904	Protein of unknown function (DUF1249); Region: DUF1249; pfam06853
715451008905	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
715451008906	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
715451008907	dimer interface [polypeptide binding]; other site
715451008908	ADP-ribose binding site [chemical binding]; other site
715451008909	active site
715451008910	nudix motif; other site
715451008911	metal binding site [ion binding]; metal-binding site
715451008912	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
715451008913	Ion transport protein; Region: Ion_trans; pfam00520
715451008914	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
715451008915	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451008916	TPR motif; other site
715451008917	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451008918	TPR motif; other site
715451008919	binding surface
715451008920	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
715451008921	TPR motif; other site
715451008922	binding surface
715451008923	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451008924	TPR motif; other site
715451008925	binding surface
715451008926	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
715451008927	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
715451008928	ATP binding site [chemical binding]; other site
715451008929	Mg++ binding site [ion binding]; other site
715451008930	motif III; other site
715451008931	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451008932	nucleotide binding region [chemical binding]; other site
715451008933	ATP-binding site [chemical binding]; other site
715451008934	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
715451008935	putative RNA binding site [nucleotide binding]; other site
715451008936	siroheme synthase; Provisional; Region: cysG; PRK10637
715451008937	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
715451008938	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
715451008939	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
715451008940	active site
715451008941	SAM binding site [chemical binding]; other site
715451008942	homodimer interface [polypeptide binding]; other site
715451008943	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
715451008944	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
715451008945	putative active site [active]
715451008946	PhoH-like protein; Region: PhoH; pfam02562
715451008947	ATP-dependent helicase HepA; Validated; Region: PRK04914
715451008948	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
715451008949	ATP binding site [chemical binding]; other site
715451008950	putative Mg++ binding site [ion binding]; other site
715451008951	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451008952	nucleotide binding region [chemical binding]; other site
715451008953	ATP-binding site [chemical binding]; other site
715451008954	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
715451008955	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
715451008956	active site
715451008957	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
715451008958	muropeptide transporter; Validated; Region: ampG; cl17669
715451008959	muropeptide transporter; Reviewed; Region: ampG; PRK11902
715451008960	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451008961	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451008962	dimer interface [polypeptide binding]; other site
715451008963	phosphorylation site [posttranslational modification]
715451008964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451008965	ATP binding site [chemical binding]; other site
715451008966	Mg2+ binding site [ion binding]; other site
715451008967	G-X-G motif; other site
715451008968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451008969	Response regulator receiver domain; Region: Response_reg; pfam00072
715451008970	active site
715451008971	phosphorylation site [posttranslational modification]
715451008972	intermolecular recognition site; other site
715451008973	dimerization interface [polypeptide binding]; other site
715451008974	Response regulator receiver domain; Region: Response_reg; pfam00072
715451008975	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451008976	active site
715451008977	phosphorylation site [posttranslational modification]
715451008978	intermolecular recognition site; other site
715451008979	dimerization interface [polypeptide binding]; other site
715451008980	PAS domain; Region: PAS; smart00091
715451008981	PAS fold; Region: PAS_4; pfam08448
715451008982	putative active site [active]
715451008983	heme pocket [chemical binding]; other site
715451008984	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451008985	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451008986	metal binding site [ion binding]; metal-binding site
715451008987	active site
715451008988	I-site; other site
715451008989	Response regulator receiver domain; Region: Response_reg; pfam00072
715451008990	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451008991	active site
715451008992	phosphorylation site [posttranslational modification]
715451008993	intermolecular recognition site; other site
715451008994	dimerization interface [polypeptide binding]; other site
715451008995	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
715451008996	thymidylate synthase; Reviewed; Region: thyA; PRK01827
715451008997	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
715451008998	dimerization interface [polypeptide binding]; other site
715451008999	active site
715451009000	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
715451009001	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
715451009002	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
715451009003	GAF domain; Region: GAF; pfam01590
715451009004	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
715451009005	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
715451009006	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
715451009007	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
715451009008	putative active site [active]
715451009009	Ap4A binding site [chemical binding]; other site
715451009010	nudix motif; other site
715451009011	putative metal binding site [ion binding]; other site
715451009012	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
715451009013	putative DNA-binding cleft [nucleotide binding]; other site
715451009014	putative DNA clevage site; other site
715451009015	molecular lever; other site
715451009016	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
715451009017	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
715451009018	Uncharacterized conserved protein [Function unknown]; Region: COG3025
715451009019	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
715451009020	putative active site [active]
715451009021	putative metal binding residues [ion binding]; other site
715451009022	signature motif; other site
715451009023	putative triphosphate binding site [ion binding]; other site
715451009024	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
715451009025	Bacterial SH3 domain homologues; Region: SH3b; smart00287
715451009026	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451009027	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451009028	dimer interface [polypeptide binding]; other site
715451009029	phosphorylation site [posttranslational modification]
715451009030	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
715451009031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451009032	active site
715451009033	phosphorylation site [posttranslational modification]
715451009034	intermolecular recognition site; other site
715451009035	dimerization interface [polypeptide binding]; other site
715451009036	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451009037	DNA binding site [nucleotide binding]
715451009038	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
715451009039	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
715451009040	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451009041	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
715451009042	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
715451009043	Proline dehydrogenase; Region: Pro_dh; pfam01619
715451009044	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
715451009045	Glutamate binding site [chemical binding]; other site
715451009046	NAD binding site [chemical binding]; other site
715451009047	catalytic residues [active]
715451009048	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
715451009049	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
715451009050	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
715451009051	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
715451009052	dimerization interface [polypeptide binding]; other site
715451009053	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
715451009054	dimer interface [polypeptide binding]; other site
715451009055	putative CheW interface [polypeptide binding]; other site
715451009056	TIGR03545 family protein; Region: TIGR03545
715451009057	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
715451009058	Septum formation initiator; Region: DivIC; cl17659
715451009059	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
715451009060	substrate binding site; other site
715451009061	dimer interface; other site
715451009062	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
715451009063	homotrimer interaction site [polypeptide binding]; other site
715451009064	zinc binding site [ion binding]; other site
715451009065	CDP-binding sites; other site
715451009066	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
715451009067	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
715451009068	Permutation of conserved domain; other site
715451009069	active site
715451009070	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
715451009071	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
715451009072	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
715451009073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451009074	S-adenosylmethionine binding site [chemical binding]; other site
715451009075	Predicted membrane protein [Function unknown]; Region: COG1238
715451009076	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
715451009077	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
715451009078	Peptidase family M23; Region: Peptidase_M23; pfam01551
715451009079	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
715451009080	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
715451009081	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451009082	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
715451009083	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
715451009084	DNA binding residues [nucleotide binding]
715451009085	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
715451009086	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
715451009087	folate binding site [chemical binding]; other site
715451009088	NADP+ binding site [chemical binding]; other site
715451009089	GTPase CgtA; Reviewed; Region: obgE; PRK12298
715451009090	GTP1/OBG; Region: GTP1_OBG; pfam01018
715451009091	Obg GTPase; Region: Obg; cd01898
715451009092	G1 box; other site
715451009093	GTP/Mg2+ binding site [chemical binding]; other site
715451009094	Switch I region; other site
715451009095	G2 box; other site
715451009096	G3 box; other site
715451009097	Switch II region; other site
715451009098	G4 box; other site
715451009099	G5 box; other site
715451009100	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
715451009101	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
715451009102	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
715451009103	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
715451009104	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
715451009105	substrate binding pocket [chemical binding]; other site
715451009106	chain length determination region; other site
715451009107	substrate-Mg2+ binding site; other site
715451009108	catalytic residues [active]
715451009109	aspartate-rich region 1; other site
715451009110	active site lid residues [active]
715451009111	aspartate-rich region 2; other site
715451009112	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
715451009113	proline dipeptidase; Provisional; Region: PRK13607
715451009114	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
715451009115	active site
715451009116	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
715451009117	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
715451009118	N-acetyl-D-glucosamine binding site [chemical binding]; other site
715451009119	catalytic residue [active]
715451009120	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
715451009121	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
715451009122	substrate binding site [chemical binding]; other site
715451009123	oxyanion hole (OAH) forming residues; other site
715451009124	trimer interface [polypeptide binding]; other site
715451009125	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
715451009126	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
715451009127	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
715451009128	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
715451009129	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
715451009130	dimer interface [polypeptide binding]; other site
715451009131	active site
715451009132	integron integrase; Region: integrase_gron; TIGR02249
715451009133	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
715451009134	Int/Topo IB signature motif; other site
715451009135	Uncharacterized conserved protein [Function unknown]; Region: COG3791
715451009136	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
715451009137	active site
715451009138	metal binding site [ion binding]; metal-binding site
715451009139	Shikimate kinase; Region: SKI; pfam01202
715451009140	PIN domain; Region: PIN_3; pfam13470
715451009141	Transposase; Region: DEDD_Tnp_IS110; pfam01548
715451009142	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
715451009143	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
715451009144	Transposase; Region: DEDD_Tnp_IS110; pfam01548
715451009145	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
715451009146	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
715451009147	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
715451009148	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
715451009149	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
715451009150	Predicted flavoprotein [General function prediction only]; Region: COG0431
715451009151	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
715451009152	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
715451009153	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
715451009154	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
715451009155	Coenzyme A binding pocket [chemical binding]; other site
715451009156	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
715451009157	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
715451009158	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
715451009159	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
715451009160	substrate binding pocket [chemical binding]; other site
715451009161	membrane-bound complex binding site; other site
715451009162	hinge residues; other site
715451009163	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
715451009164	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
715451009165	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
715451009166	Uncharacterized conserved protein [Function unknown]; Region: COG1284
715451009167	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
715451009168	alanine racemase; Reviewed; Region: alr; PRK00053
715451009169	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
715451009170	active site
715451009171	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
715451009172	substrate binding site [chemical binding]; other site
715451009173	catalytic residues [active]
715451009174	dimer interface [polypeptide binding]; other site
715451009175	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
715451009176	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
715451009177	putative active site [active]
715451009178	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
715451009179	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
715451009180	FAD binding domain; Region: FAD_binding_4; pfam01565
715451009181	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
715451009182	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
715451009183	Mechanosensitive ion channel; Region: MS_channel; pfam00924
715451009184	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
715451009185	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
715451009186	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
715451009187	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
715451009188	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
715451009189	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
715451009190	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
715451009191	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
715451009192	putative metal binding site [ion binding]; other site
715451009193	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
715451009194	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
715451009195	NAD(P) binding site [chemical binding]; other site
715451009196	catalytic residues [active]
715451009197	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
715451009198	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
715451009199	GDP-binding site [chemical binding]; other site
715451009200	ACT binding site; other site
715451009201	IMP binding site; other site
715451009202	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
715451009203	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
715451009204	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
715451009205	Protein of unknown function (DUF962); Region: DUF962; pfam06127
715451009206	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
715451009207	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
715451009208	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
715451009209	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
715451009210	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
715451009211	dimerization interface [polypeptide binding]; other site
715451009212	DPS ferroxidase diiron center [ion binding]; other site
715451009213	ion pore; other site
715451009214	Protein of unknown function (DUF461); Region: DUF461; pfam04314
715451009215	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
715451009216	ATP-grasp domain; Region: ATP-grasp; pfam02222
715451009217	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
715451009218	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
715451009219	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451009220	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451009221	dimer interface [polypeptide binding]; other site
715451009222	phosphorylation site [posttranslational modification]
715451009223	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451009224	ATP binding site [chemical binding]; other site
715451009225	Mg2+ binding site [ion binding]; other site
715451009226	G-X-G motif; other site
715451009227	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451009228	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451009229	active site
715451009230	phosphorylation site [posttranslational modification]
715451009231	intermolecular recognition site; other site
715451009232	dimerization interface [polypeptide binding]; other site
715451009233	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
715451009234	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
715451009235	metal binding site [ion binding]; metal-binding site
715451009236	putative dimer interface [polypeptide binding]; other site
715451009237	transcription termination factor Rho; Provisional; Region: rho; PRK09376
715451009238	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
715451009239	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
715451009240	RNA binding site [nucleotide binding]; other site
715451009241	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
715451009242	multimer interface [polypeptide binding]; other site
715451009243	Walker A motif; other site
715451009244	ATP binding site [chemical binding]; other site
715451009245	Walker B motif; other site
715451009246	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
715451009247	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
715451009248	catalytic residues [active]
715451009249	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
715451009250	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
715451009251	ATP binding site [chemical binding]; other site
715451009252	Mg++ binding site [ion binding]; other site
715451009253	motif III; other site
715451009254	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451009255	nucleotide binding region [chemical binding]; other site
715451009256	ATP-binding site [chemical binding]; other site
715451009257	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
715451009258	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
715451009259	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
715451009260	dimer interface [polypeptide binding]; other site
715451009261	active site
715451009262	aspartate-rich active site metal binding site; other site
715451009263	allosteric magnesium binding site [ion binding]; other site
715451009264	Schiff base residues; other site
715451009265	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
715451009266	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
715451009267	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451009268	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451009269	metal binding site [ion binding]; metal-binding site
715451009270	active site
715451009271	I-site; other site
715451009272	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
715451009273	active site
715451009274	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
715451009275	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
715451009276	sec-independent translocase; Provisional; Region: PRK01770
715451009277	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
715451009278	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
715451009279	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
715451009280	putative valine binding site [chemical binding]; other site
715451009281	dimer interface [polypeptide binding]; other site
715451009282	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
715451009283	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
715451009284	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
715451009285	PYR/PP interface [polypeptide binding]; other site
715451009286	dimer interface [polypeptide binding]; other site
715451009287	TPP binding site [chemical binding]; other site
715451009288	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
715451009289	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
715451009290	TPP-binding site [chemical binding]; other site
715451009291	dimer interface [polypeptide binding]; other site
715451009292	hypothetical protein; Provisional; Region: PRK11027
715451009293	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
715451009294	CoenzymeA binding site [chemical binding]; other site
715451009295	subunit interaction site [polypeptide binding]; other site
715451009296	PHB binding site; other site
715451009297	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451009298	binding surface
715451009299	TPR motif; other site
715451009300	Tetratricopeptide repeat; Region: TPR_12; pfam13424
715451009301	TPR repeat; Region: TPR_11; pfam13414
715451009302	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451009303	TPR motif; other site
715451009304	binding surface
715451009305	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451009306	binding surface
715451009307	TPR motif; other site
715451009308	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
715451009309	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
715451009310	potential frameshift: common BLAST hit: gi|109899772|ref|YP_663027.1| TonB-dependent receptor
715451009311	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
715451009312	catalytic site [active]
715451009313	putative active site [active]
715451009314	putative substrate binding site [chemical binding]; other site
715451009315	dimer interface [polypeptide binding]; other site
715451009316	GTPase RsgA; Reviewed; Region: PRK12288
715451009317	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
715451009318	RNA binding site [nucleotide binding]; other site
715451009319	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
715451009320	GTPase/Zn-binding domain interface [polypeptide binding]; other site
715451009321	GTP/Mg2+ binding site [chemical binding]; other site
715451009322	G4 box; other site
715451009323	G5 box; other site
715451009324	G1 box; other site
715451009325	Switch I region; other site
715451009326	G2 box; other site
715451009327	G3 box; other site
715451009328	Switch II region; other site
715451009329	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
715451009330	EamA-like transporter family; Region: EamA; pfam00892
715451009331	EamA-like transporter family; Region: EamA; pfam00892
715451009332	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
715451009333	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
715451009334	active site
715451009335	catalytic site [active]
715451009336	MerC mercury resistance protein; Region: MerC; pfam03203
715451009337	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
715451009338	NodB motif; other site
715451009339	putative active site [active]
715451009340	putative catalytic site [active]
715451009341	Zn binding site [ion binding]; other site
715451009342	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
715451009343	Peptidase family M23; Region: Peptidase_M23; pfam01551
715451009344	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
715451009345	active site residue [active]
715451009346	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
715451009347	GSH binding site [chemical binding]; other site
715451009348	catalytic residues [active]
715451009349	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
715451009350	SecA binding site; other site
715451009351	Preprotein binding site; other site
715451009352	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
715451009353	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
715451009354	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
715451009355	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
715451009356	lysophospholipase L2; Provisional; Region: PRK10749
715451009357	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
715451009358	two-component sensor protein; Provisional; Region: cpxA; PRK09470
715451009359	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
715451009360	dimerization interface [polypeptide binding]; other site
715451009361	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451009362	dimer interface [polypeptide binding]; other site
715451009363	phosphorylation site [posttranslational modification]
715451009364	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451009365	ATP binding site [chemical binding]; other site
715451009366	Mg2+ binding site [ion binding]; other site
715451009367	G-X-G motif; other site
715451009368	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
715451009369	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451009370	active site
715451009371	phosphorylation site [posttranslational modification]
715451009372	intermolecular recognition site; other site
715451009373	dimerization interface [polypeptide binding]; other site
715451009374	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451009375	DNA binding site [nucleotide binding]
715451009376	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
715451009377	dimer interface [polypeptide binding]; other site
715451009378	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
715451009379	dimer interface [polypeptide binding]; other site
715451009380	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
715451009381	Flagellar L-ring protein; Region: FlgH; pfam02107
715451009382	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
715451009383	active site
715451009384	dimer interfaces [polypeptide binding]; other site
715451009385	catalytic residues [active]
715451009386	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
715451009387	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
715451009388	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
715451009389	nucleotide binding site [chemical binding]; other site
715451009390	substrate binding site [chemical binding]; other site
715451009391	ornithine carbamoyltransferase; Provisional; Region: PRK14805
715451009392	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
715451009393	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
715451009394	argininosuccinate synthase; Provisional; Region: PRK13820
715451009395	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
715451009396	ANP binding site [chemical binding]; other site
715451009397	Substrate Binding Site II [chemical binding]; other site
715451009398	Substrate Binding Site I [chemical binding]; other site
715451009399	argininosuccinate lyase; Provisional; Region: PRK04833
715451009400	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
715451009401	active sites [active]
715451009402	tetramer interface [polypeptide binding]; other site
715451009403	N-acetylglutamate synthase; Validated; Region: PRK05279
715451009404	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
715451009405	putative feedback inhibition sensing region; other site
715451009406	putative nucleotide binding site [chemical binding]; other site
715451009407	putative substrate binding site [chemical binding]; other site
715451009408	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
715451009409	Coenzyme A binding pocket [chemical binding]; other site
715451009410	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
715451009411	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451009412	metal binding site [ion binding]; metal-binding site
715451009413	active site
715451009414	I-site; other site
715451009415	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451009416	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
715451009417	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
715451009418	Protein of unknown function (DUF2855); Region: DUF2855; pfam11017
715451009419	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
715451009420	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
715451009421	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451009422	WHG domain; Region: WHG; pfam13305
715451009423	putative S-transferase; Provisional; Region: PRK11752
715451009424	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
715451009425	C-terminal domain interface [polypeptide binding]; other site
715451009426	GSH binding site (G-site) [chemical binding]; other site
715451009427	dimer interface [polypeptide binding]; other site
715451009428	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
715451009429	dimer interface [polypeptide binding]; other site
715451009430	N-terminal domain interface [polypeptide binding]; other site
715451009431	active site
715451009432	malate dehydrogenase; Provisional; Region: PRK13529
715451009433	Malic enzyme, N-terminal domain; Region: malic; pfam00390
715451009434	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
715451009435	NAD(P) binding site [chemical binding]; other site
715451009436	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
715451009437	Transglycosylase; Region: Transgly; pfam00912
715451009438	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
715451009439	Cell division protein FtsA; Region: FtsA; cl17206
715451009440	Competence protein A; Region: Competence_A; pfam11104
715451009441	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
715451009442	nucleotide binding site [chemical binding]; other site
715451009443	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
715451009444	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
715451009445	Pilus assembly protein, PilO; Region: PilO; pfam04350
715451009446	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
715451009447	Pilus assembly protein, PilP; Region: PilP; pfam04351
715451009448	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
715451009449	Secretin and TonB N terminus short domain; Region: STN; smart00965
715451009450	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
715451009451	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
715451009452	shikimate kinase; Reviewed; Region: aroK; PRK00131
715451009453	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
715451009454	ADP binding site [chemical binding]; other site
715451009455	magnesium binding site [ion binding]; other site
715451009456	putative shikimate binding site; other site
715451009457	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
715451009458	active site
715451009459	dimer interface [polypeptide binding]; other site
715451009460	metal binding site [ion binding]; metal-binding site
715451009461	AAA domain; Region: AAA_22; pfam13401
715451009462	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266
715451009463	Sporulation related domain; Region: SPOR; pfam05036
715451009464	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
715451009465	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
715451009466	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
715451009467	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
715451009468	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
715451009469	substrate binding site [chemical binding]; other site
715451009470	hexamer interface [polypeptide binding]; other site
715451009471	metal binding site [ion binding]; metal-binding site
715451009472	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
715451009473	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
715451009474	active site
715451009475	HIGH motif; other site
715451009476	dimer interface [polypeptide binding]; other site
715451009477	KMSKS motif; other site
715451009478	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
715451009479	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
715451009480	glutamine binding [chemical binding]; other site
715451009481	catalytic triad [active]
715451009482	HDOD domain; Region: HDOD; pfam08668
715451009483	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
715451009484	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
715451009485	inhibitor-cofactor binding pocket; inhibition site
715451009486	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451009487	catalytic residue [active]
715451009488	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
715451009489	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
715451009490	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
715451009491	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
715451009492	NAD(P) binding site [chemical binding]; other site
715451009493	catalytic residues [active]
715451009494	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
715451009495	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451009496	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451009497	metal binding site [ion binding]; metal-binding site
715451009498	active site
715451009499	I-site; other site
715451009500	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451009501	Heme NO binding; Region: HNOB; pfam07700
715451009502	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
715451009503	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
715451009504	CAP-like domain; other site
715451009505	active site
715451009506	primary dimer interface [polypeptide binding]; other site
715451009507	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
715451009508	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
715451009509	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451009510	dimer interface [polypeptide binding]; other site
715451009511	phosphorylation site [posttranslational modification]
715451009512	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451009513	ATP binding site [chemical binding]; other site
715451009514	Mg2+ binding site [ion binding]; other site
715451009515	G-X-G motif; other site
715451009516	Response regulator receiver domain; Region: Response_reg; pfam00072
715451009517	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451009518	active site
715451009519	phosphorylation site [posttranslational modification]
715451009520	intermolecular recognition site; other site
715451009521	dimerization interface [polypeptide binding]; other site
715451009522	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
715451009523	putative binding surface; other site
715451009524	active site
715451009525	Protein of unknown function (DUF2982); Region: DUF2982; pfam11201
715451009526	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
715451009527	Protein export membrane protein; Region: SecD_SecF; cl14618
715451009528	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
715451009529	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
715451009530	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451009531	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
715451009532	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451009533	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
715451009534	aspartate carbamoyltransferase; Provisional; Region: PRK08192
715451009535	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
715451009536	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
715451009537	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
715451009538	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
715451009539	inhibitor-cofactor binding pocket; inhibition site
715451009540	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451009541	catalytic residue [active]
715451009542	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
715451009543	cyclase homology domain; Region: CHD; cd07302
715451009544	nucleotidyl binding site; other site
715451009545	metal binding site [ion binding]; metal-binding site
715451009546	dimer interface [polypeptide binding]; other site
715451009547	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
715451009548	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
715451009549	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
715451009550	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
715451009551	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
715451009552	Nitrogen regulatory protein P-II; Region: P-II; smart00938
715451009553	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
715451009554	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
715451009555	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
715451009556	Protein of unknown function (DUF808); Region: DUF808; pfam05661
715451009557	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14247
715451009558	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
715451009559	Transglycosylase; Region: Transgly; pfam00912
715451009560	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
715451009561	Transglycosylase SLT domain; Region: SLT_2; pfam13406
715451009562	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
715451009563	N-acetyl-D-glucosamine binding site [chemical binding]; other site
715451009564	catalytic residue [active]
715451009565	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
715451009566	potential frameshift: common BLAST hit: gi|114564575|ref|YP_752089.1| integrase catalytic subunit
715451009567	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
715451009568	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451009569	Walker A motif; other site
715451009570	ATP binding site [chemical binding]; other site
715451009571	Walker B motif; other site
715451009572	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
715451009573	DNA binding site [nucleotide binding]
715451009574	active site
715451009575	Int/Topo IB signature motif; other site
715451009576	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
715451009577	active site
715451009578	catalytic residues [active]
715451009579	DNA binding site [nucleotide binding]
715451009580	Int/Topo IB signature motif; other site
715451009581	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
715451009582	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
715451009583	ATP binding site [chemical binding]; other site
715451009584	putative Mg++ binding site [ion binding]; other site
715451009585	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451009586	nucleotide binding region [chemical binding]; other site
715451009587	ATP-binding site [chemical binding]; other site
715451009588	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
715451009589	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
715451009590	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
715451009591	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
715451009592	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
715451009593	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
715451009594	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
715451009595	putative active site [active]
715451009596	putative substrate binding site [chemical binding]; other site
715451009597	putative cosubstrate binding site; other site
715451009598	catalytic site [active]
715451009599	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
715451009600	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
715451009601	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
715451009602	active site
715451009603	Zn binding site [ion binding]; other site
715451009604	Cache domain; Region: Cache_1; pfam02743
715451009605	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
715451009606	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
715451009607	dimerization interface [polypeptide binding]; other site
715451009608	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
715451009609	dimer interface [polypeptide binding]; other site
715451009610	putative CheW interface [polypeptide binding]; other site
715451009611	SdiA-regulated; Region: SdiA-regulated; cd09971
715451009612	putative active site [active]
715451009613	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
715451009614	TrkA-N domain; Region: TrkA_N; pfam02254
715451009615	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
715451009616	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
715451009617	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
715451009618	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
715451009619	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
715451009620	putative active site [active]
715451009621	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
715451009622	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
715451009623	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
715451009624	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
715451009625	23S rRNA interface [nucleotide binding]; other site
715451009626	putative translocon interaction site; other site
715451009627	signal recognition particle (SRP54) interaction site; other site
715451009628	L23 interface [polypeptide binding]; other site
715451009629	trigger factor interaction site; other site
715451009630	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
715451009631	23S rRNA interface [nucleotide binding]; other site
715451009632	5S rRNA interface [nucleotide binding]; other site
715451009633	putative antibiotic binding site [chemical binding]; other site
715451009634	L25 interface [polypeptide binding]; other site
715451009635	L27 interface [polypeptide binding]; other site
715451009636	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
715451009637	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
715451009638	G-X-X-G motif; other site
715451009639	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
715451009640	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
715451009641	putative translocon binding site; other site
715451009642	protein-rRNA interface [nucleotide binding]; other site
715451009643	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
715451009644	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
715451009645	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
715451009646	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
715451009647	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
715451009648	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
715451009649	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
715451009650	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
715451009651	GAF domain; Region: GAF; cl17456
715451009652	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
715451009653	type II secretion system protein E; Region: type_II_gspE; TIGR02533
715451009654	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
715451009655	Walker A motif; other site
715451009656	ATP binding site [chemical binding]; other site
715451009657	Walker B motif; other site
715451009658	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
715451009659	Sel1-like repeats; Region: SEL1; smart00671
715451009660	aconitate hydratase; Validated; Region: PRK09277
715451009661	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
715451009662	substrate binding site [chemical binding]; other site
715451009663	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
715451009664	ligand binding site [chemical binding]; other site
715451009665	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
715451009666	substrate binding site [chemical binding]; other site
715451009667	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
715451009668	catalytic core [active]
715451009669	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
715451009670	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
715451009671	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
715451009672	active site
715451009673	NAD binding site [chemical binding]; other site
715451009674	metal binding site [ion binding]; metal-binding site
715451009675	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
715451009676	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
715451009677	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
715451009678	potential catalytic triad [active]
715451009679	conserved cys residue [active]
715451009680	transcriptional regulator; Provisional; Region: PRK10632
715451009681	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451009682	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
715451009683	putative effector binding pocket; other site
715451009684	dimerization interface [polypeptide binding]; other site
715451009685	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
715451009686	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
715451009687	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
715451009688	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
715451009689	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
715451009690	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
715451009691	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
715451009692	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451009693	putative substrate translocation pore; other site
715451009694	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
715451009695	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
715451009696	Metal-binding active site; metal-binding site
715451009697	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
715451009698	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
715451009699	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
715451009700	Transcriptional regulators [Transcription]; Region: PurR; COG1609
715451009701	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
715451009702	DNA binding site [nucleotide binding]
715451009703	domain linker motif; other site
715451009704	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
715451009705	dimerization interface [polypeptide binding]; other site
715451009706	ligand binding site [chemical binding]; other site
715451009707	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
715451009708	Protein of unknown function (DUF3392); Region: DUF3392; pfam11872
715451009709	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
715451009710	Alginate lyase; Region: Alginate_lyase2; pfam08787
715451009711	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451009712	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451009713	dimer interface [polypeptide binding]; other site
715451009714	phosphorylation site [posttranslational modification]
715451009715	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451009716	ATP binding site [chemical binding]; other site
715451009717	Mg2+ binding site [ion binding]; other site
715451009718	G-X-G motif; other site
715451009719	Response regulator receiver domain; Region: Response_reg; pfam00072
715451009720	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451009721	active site
715451009722	phosphorylation site [posttranslational modification]
715451009723	intermolecular recognition site; other site
715451009724	dimerization interface [polypeptide binding]; other site
715451009725	Helix-turn-helix domain; Region: HTH_18; pfam12833
715451009726	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
715451009727	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
715451009728	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
715451009729	active site
715451009730	motif I; other site
715451009731	motif II; other site
715451009732	EamA-like transporter family; Region: EamA; pfam00892
715451009733	EamA-like transporter family; Region: EamA; cl17759
715451009734	Trehalase; Region: Trehalase; cl17346
715451009735	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
715451009736	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451009737	putative substrate translocation pore; other site
715451009738	Transcriptional regulators [Transcription]; Region: PurR; COG1609
715451009739	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
715451009740	DNA binding site [nucleotide binding]
715451009741	domain linker motif; other site
715451009742	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
715451009743	putative dimerization interface [polypeptide binding]; other site
715451009744	putative ligand binding site [chemical binding]; other site
715451009745	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451009746	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451009747	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451009748	heat shock protein HtpX; Provisional; Region: PRK05457
715451009749	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
715451009750	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
715451009751	motif II; other site
715451009752	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
715451009753	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451009754	active site
715451009755	phosphorylation site [posttranslational modification]
715451009756	intermolecular recognition site; other site
715451009757	dimerization interface [polypeptide binding]; other site
715451009758	CheB methylesterase; Region: CheB_methylest; pfam01339
715451009759	CheD chemotactic sensory transduction; Region: CheD; cl00810
715451009760	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
715451009761	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
715451009762	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
715451009763	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
715451009764	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451009765	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
715451009766	putative active site [active]
715451009767	heme pocket [chemical binding]; other site
715451009768	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451009769	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
715451009770	putative active site [active]
715451009771	heme pocket [chemical binding]; other site
715451009772	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451009773	putative active site [active]
715451009774	heme pocket [chemical binding]; other site
715451009775	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
715451009776	dimerization interface [polypeptide binding]; other site
715451009777	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
715451009778	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
715451009779	dimer interface [polypeptide binding]; other site
715451009780	putative CheW interface [polypeptide binding]; other site
715451009781	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
715451009782	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
715451009783	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
715451009784	putative binding surface; other site
715451009785	active site
715451009786	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
715451009787	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451009788	ATP binding site [chemical binding]; other site
715451009789	Mg2+ binding site [ion binding]; other site
715451009790	G-X-G motif; other site
715451009791	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
715451009792	Response regulator receiver domain; Region: Response_reg; pfam00072
715451009793	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451009794	active site
715451009795	phosphorylation site [posttranslational modification]
715451009796	intermolecular recognition site; other site
715451009797	dimerization interface [polypeptide binding]; other site
715451009798	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
715451009799	META domain; Region: META; pfam03724
715451009800	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
715451009801	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
715451009802	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451009803	active site
715451009804	phosphorylation site [posttranslational modification]
715451009805	intermolecular recognition site; other site
715451009806	dimerization interface [polypeptide binding]; other site
715451009807	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451009808	DNA binding site [nucleotide binding]
715451009809	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
715451009810	dimerization interface [polypeptide binding]; other site
715451009811	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451009812	dimer interface [polypeptide binding]; other site
715451009813	phosphorylation site [posttranslational modification]
715451009814	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451009815	ATP binding site [chemical binding]; other site
715451009816	Mg2+ binding site [ion binding]; other site
715451009817	G-X-G motif; other site
715451009818	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
715451009819	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
715451009820	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
715451009821	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451009822	N-terminal plug; other site
715451009823	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
715451009824	ligand-binding site [chemical binding]; other site
715451009825	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
715451009826	active site
715451009827	catalytic residues [active]
715451009828	DNA binding site [nucleotide binding]
715451009829	Int/Topo IB signature motif; other site
715451009830	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451009831	AAA domain; Region: AAA_21; pfam13304
715451009832	Walker A/P-loop; other site
715451009833	ATP binding site [chemical binding]; other site
715451009834	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451009835	Walker B; other site
715451009836	D-loop; other site
715451009837	H-loop/switch region; other site
715451009838	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
715451009839	putative active site [active]
715451009840	putative metal-binding site [ion binding]; other site
715451009841	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
715451009842	Putative transposase; Region: Y2_Tnp; pfam04986
715451009843	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
715451009844	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
715451009845	active site residue [active]
715451009846	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
715451009847	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
715451009848	Catalytic site [active]
715451009849	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
715451009850	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
715451009851	active site
715451009852	DNA binding site [nucleotide binding]
715451009853	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
715451009854	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
715451009855	active site
715451009856	DNA binding site [nucleotide binding]
715451009857	Int/Topo IB signature motif; other site
715451009858	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
715451009859	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451009860	Walker A motif; other site
715451009861	ATP binding site [chemical binding]; other site
715451009862	Walker B motif; other site
715451009863	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451009864	Walker A motif; other site
715451009865	ATP binding site [chemical binding]; other site
715451009866	Walker B motif; other site
715451009867	arginine finger; other site
715451009868	Protein of unknown function (DUF2787); Region: DUF2787; pfam10980
715451009869	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
715451009870	Protein of unknown function (DUF2787); Region: DUF2787; pfam10980
715451009871	Fic family protein [Function unknown]; Region: COG3177
715451009872	Fic/DOC family; Region: Fic; pfam02661
715451009873	Protein of unknown function, DUF; Region: DUF413; cl10479
715451009874	Restriction endonuclease [Defense mechanisms]; Region: COG3587
715451009875	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
715451009876	ATP binding site [chemical binding]; other site
715451009877	putative Mg++ binding site [ion binding]; other site
715451009878	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
715451009879	DNA methylase; Region: N6_N4_Mtase; pfam01555
715451009880	DNA methylase; Region: N6_N4_Mtase; pfam01555
715451009881	Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
715451009882	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311
715451009883	putative active site [active]
715451009884	catalytic site [active]
715451009885	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
715451009886	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
715451009887	ATP binding site [chemical binding]; other site
715451009888	putative Mg++ binding site [ion binding]; other site
715451009889	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451009890	nucleotide binding region [chemical binding]; other site
715451009891	ATP-binding site [chemical binding]; other site
715451009892	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
715451009893	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
715451009894	active site
715451009895	catalytic residues [active]
715451009896	DNA binding site [nucleotide binding]
715451009897	Int/Topo IB signature motif; other site
715451009898	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
715451009899	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
715451009900	active site
715451009901	DNA binding site [nucleotide binding]
715451009902	Int/Topo IB signature motif; other site
715451009903	LabA_like proteins; Region: LabA_like; cd06167
715451009904	putative metal binding site [ion binding]; other site
715451009905	Uncharacterized conserved protein [Function unknown]; Region: COG1432
715451009906	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
715451009907	active site
715451009908	catalytic residues [active]
715451009909	DNA binding site [nucleotide binding]
715451009910	Int/Topo IB signature motif; other site
715451009911	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
715451009912	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451009913	Walker A motif; other site
715451009914	ATP binding site [chemical binding]; other site
715451009915	Walker B motif; other site
715451009916	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
715451009917	Integrase core domain; Region: rve; pfam00665
715451009918	multiple promoter invertase; Provisional; Region: mpi; PRK13413
715451009919	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
715451009920	catalytic residues [active]
715451009921	catalytic nucleophile [active]
715451009922	Presynaptic Site I dimer interface [polypeptide binding]; other site
715451009923	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
715451009924	Synaptic Flat tetramer interface [polypeptide binding]; other site
715451009925	Synaptic Site I dimer interface [polypeptide binding]; other site
715451009926	DNA binding site [nucleotide binding]
715451009927	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
715451009928	DNA-binding interface [nucleotide binding]; DNA binding site
715451009929	Beta protein; Region: Beta_protein; pfam14350
715451009930	Domain of unknown function (DUF955); Region: DUF955; pfam06114
715451009931	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
715451009932	Coenzyme A binding pocket [chemical binding]; other site
715451009933	Domain of unknown function (DUF4224); Region: DUF4224; pfam13986
715451009934	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
715451009935	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
715451009936	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
715451009937	active site
715451009938	DNA binding site [nucleotide binding]
715451009939	Int/Topo IB signature motif; other site
715451009940	oxidative damage protection protein; Provisional; Region: PRK05408
715451009941	adenine DNA glycosylase; Provisional; Region: PRK10880
715451009942	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
715451009943	minor groove reading motif; other site
715451009944	helix-hairpin-helix signature motif; other site
715451009945	substrate binding pocket [chemical binding]; other site
715451009946	active site
715451009947	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
715451009948	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
715451009949	DNA binding and oxoG recognition site [nucleotide binding]
715451009950	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
715451009951	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
715451009952	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
715451009953	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
715451009954	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451009955	S-adenosylmethionine binding site [chemical binding]; other site
715451009956	glycogen synthase; Provisional; Region: glgA; PRK00654
715451009957	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
715451009958	ADP-binding pocket [chemical binding]; other site
715451009959	homodimer interface [polypeptide binding]; other site
715451009960	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
715451009961	dimer interface [polypeptide binding]; other site
715451009962	phosphorylation site [posttranslational modification]
715451009963	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451009964	ATP binding site [chemical binding]; other site
715451009965	Mg2+ binding site [ion binding]; other site
715451009966	G-X-G motif; other site
715451009967	two-component response regulator; Provisional; Region: PRK11173
715451009968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451009969	active site
715451009970	phosphorylation site [posttranslational modification]
715451009971	intermolecular recognition site; other site
715451009972	dimerization interface [polypeptide binding]; other site
715451009973	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451009974	DNA binding site [nucleotide binding]
715451009975	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
715451009976	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
715451009977	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
715451009978	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
715451009979	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
715451009980	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
715451009981	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
715451009982	peptidase PmbA; Provisional; Region: PRK11040
715451009983	hypothetical protein; Provisional; Region: PRK05255
715451009984	protease TldD; Provisional; Region: tldD; PRK10735
715451009985	nitrilase; Region: PLN02798
715451009986	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
715451009987	putative active site [active]
715451009988	catalytic triad [active]
715451009989	dimer interface [polypeptide binding]; other site
715451009990	TIGR02099 family protein; Region: TIGR02099
715451009991	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
715451009992	ribonuclease G; Provisional; Region: PRK11712
715451009993	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
715451009994	homodimer interface [polypeptide binding]; other site
715451009995	oligonucleotide binding site [chemical binding]; other site
715451009996	Maf-like protein; Region: Maf; pfam02545
715451009997	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
715451009998	active site
715451009999	dimer interface [polypeptide binding]; other site
715451010000	rod shape-determining protein MreD; Region: MreD; cl01087
715451010001	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
715451010002	rod shape-determining protein MreC; Region: MreC; pfam04085
715451010003	rod shape-determining protein MreB; Provisional; Region: PRK13927
715451010004	MreB and similar proteins; Region: MreB_like; cd10225
715451010005	nucleotide binding site [chemical binding]; other site
715451010006	Mg binding site [ion binding]; other site
715451010007	putative protofilament interaction site [polypeptide binding]; other site
715451010008	RodZ interaction site [polypeptide binding]; other site
715451010009	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
715451010010	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
715451010011	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
715451010012	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
715451010013	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
715451010014	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
715451010015	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
715451010016	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
715451010017	Walker A motif; other site
715451010018	ATP binding site [chemical binding]; other site
715451010019	Walker B motif; other site
715451010020	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451010021	binding surface
715451010022	Tetratricopeptide repeat; Region: TPR_16; pfam13432
715451010023	TPR motif; other site
715451010024	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
715451010025	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451010026	Walker A motif; other site
715451010027	ATP binding site [chemical binding]; other site
715451010028	Walker B motif; other site
715451010029	arginine finger; other site
715451010030	Secretin N-terminal domain; Region: Secretin_N_2; pfam07655
715451010031	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
715451010032	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
715451010033	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
715451010034	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
715451010035	catalytic core [active]
715451010036	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
715451010037	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
715451010038	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
715451010039	putative DNA binding site [nucleotide binding]; other site
715451010040	putative Zn2+ binding site [ion binding]; other site
715451010041	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
715451010042	glycerol kinase; Provisional; Region: glpK; PRK00047
715451010043	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
715451010044	N- and C-terminal domain interface [polypeptide binding]; other site
715451010045	active site
715451010046	MgATP binding site [chemical binding]; other site
715451010047	catalytic site [active]
715451010048	metal binding site [ion binding]; metal-binding site
715451010049	glycerol binding site [chemical binding]; other site
715451010050	homotetramer interface [polypeptide binding]; other site
715451010051	homodimer interface [polypeptide binding]; other site
715451010052	FBP binding site [chemical binding]; other site
715451010053	protein IIAGlc interface [polypeptide binding]; other site
715451010054	potential frameshift: common BLAST hit: gi|109899987|ref|YP_663242.1| TonB-dependent receptor
715451010055	potential frameshift: common BLAST hit: gi|109899987|ref|YP_663242.1| TonB-dependent receptor
715451010056	putative transporter; Provisional; Region: PRK10484
715451010057	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
715451010058	Na binding site [ion binding]; other site
715451010059	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
715451010060	SapC; Region: SapC; pfam07277
715451010061	SapC; Region: SapC; pfam07277
715451010062	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
715451010063	Melibiase; Region: Melibiase; pfam02065
715451010064	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
715451010065	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
715451010066	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
715451010067	inhibitor site; inhibition site
715451010068	active site
715451010069	dimer interface [polypeptide binding]; other site
715451010070	catalytic residue [active]
715451010071	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
715451010072	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
715451010073	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
715451010074	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451010075	dimer interface [polypeptide binding]; other site
715451010076	phosphorylation site [posttranslational modification]
715451010077	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451010078	ATP binding site [chemical binding]; other site
715451010079	Mg2+ binding site [ion binding]; other site
715451010080	G-X-G motif; other site
715451010081	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451010082	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451010083	active site
715451010084	phosphorylation site [posttranslational modification]
715451010085	intermolecular recognition site; other site
715451010086	dimerization interface [polypeptide binding]; other site
715451010087	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
715451010088	putative binding surface; other site
715451010089	active site
715451010090	Response regulator receiver domain; Region: Response_reg; pfam00072
715451010091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451010092	active site
715451010093	phosphorylation site [posttranslational modification]
715451010094	intermolecular recognition site; other site
715451010095	dimerization interface [polypeptide binding]; other site
715451010096	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
715451010097	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
715451010098	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
715451010099	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451010100	binding surface
715451010101	TPR motif; other site
715451010102	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
715451010103	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
715451010104	dimer interface [polypeptide binding]; other site
715451010105	ssDNA binding site [nucleotide binding]; other site
715451010106	tetramer (dimer of dimers) interface [polypeptide binding]; other site
715451010107	Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325
715451010108	putative transporter; Provisional; Region: PRK10484
715451010109	Na binding site [ion binding]; other site
715451010110	substrate binding site [chemical binding]; other site
715451010111	galactokinase; Provisional; Region: PRK05101
715451010112	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
715451010113	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
715451010114	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
715451010115	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
715451010116	dimer interface [polypeptide binding]; other site
715451010117	active site
715451010118	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
715451010119	active site
715451010120	catalytic residues [active]
715451010121	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
715451010122	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
715451010123	DNA binding site [nucleotide binding]
715451010124	domain linker motif; other site
715451010125	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
715451010126	dimerization interface (closed form) [polypeptide binding]; other site
715451010127	ligand binding site [chemical binding]; other site
715451010128	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
715451010129	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
715451010130	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
715451010131	active site
715451010132	motif I; other site
715451010133	motif II; other site
715451010134	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451010135	Major Facilitator Superfamily; Region: MFS_1; pfam07690
715451010136	putative substrate translocation pore; other site
715451010137	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
715451010138	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
715451010139	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
715451010140	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
715451010141	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
715451010142	nucleotide binding site [chemical binding]; other site
715451010143	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
715451010144	putative NEF/HSP70 interaction site [polypeptide binding]; other site
715451010145	nucleotide binding site [chemical binding]; other site
715451010146	SBD interface [polypeptide binding]; other site
715451010147	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
715451010148	active site
715451010149	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
715451010150	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
715451010151	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
715451010152	dimer interface [polypeptide binding]; other site
715451010153	substrate binding site [chemical binding]; other site
715451010154	metal binding sites [ion binding]; metal-binding site
715451010155	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
715451010156	AMP binding site [chemical binding]; other site
715451010157	metal binding site [ion binding]; metal-binding site
715451010158	active site
715451010159	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
715451010160	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
715451010161	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
715451010162	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
715451010163	aromatic acid decarboxylase; Validated; Region: PRK05920
715451010164	Flavoprotein; Region: Flavoprotein; pfam02441
715451010165	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
715451010166	active site
715451010167	Zn binding site [ion binding]; other site
715451010168	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
715451010169	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
715451010170	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
715451010171	active site
715451010172	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
715451010173	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627
715451010174	diaminopimelate decarboxylase; Region: lysA; TIGR01048
715451010175	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
715451010176	active site
715451010177	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
715451010178	substrate binding site [chemical binding]; other site
715451010179	catalytic residues [active]
715451010180	dimer interface [polypeptide binding]; other site
715451010181	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
715451010182	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
715451010183	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
715451010184	Protein of unknown function, DUF484; Region: DUF484; cl17449
715451010185	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
715451010186	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
715451010187	active site
715451010188	DNA binding site [nucleotide binding]
715451010189	Int/Topo IB signature motif; other site
715451010190	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
715451010191	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
715451010192	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
715451010193	serine acetyltransferase; Provisional; Region: cysE; PRK11132
715451010194	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
715451010195	trimer interface [polypeptide binding]; other site
715451010196	active site
715451010197	substrate binding site [chemical binding]; other site
715451010198	CoA binding site [chemical binding]; other site
715451010199	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
715451010200	Part of AAA domain; Region: AAA_19; pfam13245
715451010201	Family description; Region: UvrD_C_2; pfam13538
715451010202	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451010203	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451010204	active site
715451010205	phosphorylation site [posttranslational modification]
715451010206	intermolecular recognition site; other site
715451010207	dimerization interface [polypeptide binding]; other site
715451010208	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451010209	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451010210	metal binding site [ion binding]; metal-binding site
715451010211	active site
715451010212	I-site; other site
715451010213	Predicted permeases [General function prediction only]; Region: RarD; COG2962
715451010214	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
715451010215	MgtE intracellular N domain; Region: MgtE_N; pfam03448
715451010216	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
715451010217	Divalent cation transporter; Region: MgtE; pfam01769
715451010218	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
715451010219	CoenzymeA binding site [chemical binding]; other site
715451010220	subunit interaction site [polypeptide binding]; other site
715451010221	PHB binding site; other site
715451010222	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
715451010223	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
715451010224	ATP binding site [chemical binding]; other site
715451010225	putative Mg++ binding site [ion binding]; other site
715451010226	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451010227	nucleotide binding region [chemical binding]; other site
715451010228	ATP-binding site [chemical binding]; other site
715451010229	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
715451010230	HRDC domain; Region: HRDC; pfam00570
715451010231	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
715451010232	N-terminal domain interface [polypeptide binding]; other site
715451010233	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
715451010234	PLD-like domain; Region: PLDc_2; pfam13091
715451010235	putative homodimer interface [polypeptide binding]; other site
715451010236	putative active site [active]
715451010237	catalytic site [active]
715451010238	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
715451010239	ssDNA binding site [nucleotide binding]; other site
715451010240	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
715451010241	dimer interface [polypeptide binding]; other site
715451010242	tetramer (dimer of dimers) interface [polypeptide binding]; other site
715451010243	Probable transposase; Region: OrfB_IS605; pfam01385
715451010244	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
715451010245	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
715451010246	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
715451010247	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
715451010248	RES domain; Region: RES; cl02411
715451010249	DDE superfamily endonuclease; Region: DDE_5; cl17874
715451010250	DNA photolyase; Region: DNA_photolyase; pfam00875
715451010251	RES domain; Region: RES; smart00953
715451010252	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
715451010253	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
715451010254	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451010255	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
715451010256	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
715451010257	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
715451010258	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451010259	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
715451010260	Protein of unknown function (DUF938); Region: DUF938; pfam06080
715451010261	Methyltransferase domain; Region: Methyltransf_23; pfam13489
715451010262	Hemerythrin; Region: Hemerythrin; cd12107
715451010263	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
715451010264	DDE superfamily endonuclease; Region: DDE_5; cl17874
715451010265	TraL protein; Region: TraL; cl06278
715451010266	TraE protein; Region: TraE; cl05060
715451010267	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
715451010268	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
715451010269	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296
715451010270	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
715451010271	Sel1-like repeats; Region: SEL1; smart00671
715451010272	potential frameshift: common BLAST hit: gi|229608821|ref|YP_002879469.1| transposase Tn3 family protein
715451010273	potential frameshift: common BLAST hit: gi|114564622|ref|YP_752136.1| transposase Tn3 family protein
715451010274	DDE superfamily endonuclease; Region: DDE_5; cl17874
715451010275	glutathionine S-transferase; Provisional; Region: PRK10542
715451010276	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
715451010277	C-terminal domain interface [polypeptide binding]; other site
715451010278	GSH binding site (G-site) [chemical binding]; other site
715451010279	dimer interface [polypeptide binding]; other site
715451010280	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
715451010281	dimer interface [polypeptide binding]; other site
715451010282	N-terminal domain interface [polypeptide binding]; other site
715451010283	substrate binding pocket (H-site) [chemical binding]; other site
715451010284	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
715451010285	Prephenate dehydratase; Region: PDT; pfam00800
715451010286	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
715451010287	putative L-Phe binding site [chemical binding]; other site
715451010288	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
715451010289	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
715451010290	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
715451010291	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
715451010292	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
715451010293	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
715451010294	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
715451010295	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
715451010296	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
715451010297	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
715451010298	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
715451010299	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
715451010300	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
715451010301	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
715451010302	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
715451010303	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
715451010304	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
715451010305	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
715451010306	putative catalytic residue [active]
715451010307	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
715451010308	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
715451010309	NAD(P) binding site [chemical binding]; other site
715451010310	active site
715451010311	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
715451010312	inter-subunit interface; other site
715451010313	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
715451010314	iron-sulfur cluster [ion binding]; other site
715451010315	[2Fe-2S] cluster binding site [ion binding]; other site
715451010316	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
715451010317	beta subunit interface [polypeptide binding]; other site
715451010318	alpha subunit interface [polypeptide binding]; other site
715451010319	active site
715451010320	substrate binding site [chemical binding]; other site
715451010321	Fe binding site [ion binding]; other site
715451010322	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
715451010323	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
715451010324	active site
715451010325	metal binding site [ion binding]; metal-binding site
715451010326	Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673
715451010327	dimer interface [polypeptide binding]; other site
715451010328	tetramer interface [polypeptide binding]; other site
715451010329	Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA); Region: CHBPH_aldolase; cd00952
715451010330	N-acetylneuraminate lyase; Provisional; Region: PRK04147
715451010331	putative active site [active]
715451010332	catalytic residue [active]
715451010333	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
715451010334	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
715451010335	NAD(P) binding site [chemical binding]; other site
715451010336	catalytic residues [active]
715451010337	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
715451010338	[2Fe-2S] cluster binding site [ion binding]; other site
715451010339	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
715451010340	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
715451010341	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
715451010342	Cupin domain; Region: Cupin_2; pfam07883
715451010343	Transcriptional regulators [Transcription]; Region: GntR; COG1802
715451010344	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
715451010345	DNA-binding site [nucleotide binding]; DNA binding site
715451010346	FCD domain; Region: FCD; pfam07729
715451010347	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
715451010348	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
715451010349	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
715451010350	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
715451010351	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
715451010352	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
715451010353	Fic family protein [Function unknown]; Region: COG3177
715451010354	Fic/DOC family; Region: Fic; pfam02661
715451010355	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
715451010356	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
715451010357	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
715451010358	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
715451010359	Magnesium ion binding site [ion binding]; other site
715451010360	ParB-like nuclease domain; Region: ParB; smart00470
715451010361	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
715451010362	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
715451010363	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
715451010364	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
715451010365	Cupin domain; Region: Cupin_2; pfam07883
715451010366	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
715451010367	maleylacetoacetate isomerase; Region: maiA; TIGR01262
715451010368	C-terminal domain interface [polypeptide binding]; other site
715451010369	GSH binding site (G-site) [chemical binding]; other site
715451010370	putative dimer interface [polypeptide binding]; other site
715451010371	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
715451010372	dimer interface [polypeptide binding]; other site
715451010373	N-terminal domain interface [polypeptide binding]; other site
715451010374	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
715451010375	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451010376	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451010377	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
715451010378	putative dimerization interface [polypeptide binding]; other site
715451010379	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451010380	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451010381	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
715451010382	substrate binding pocket [chemical binding]; other site
715451010383	dimerization interface [polypeptide binding]; other site
715451010384	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
715451010385	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
715451010386	iron-sulfur cluster [ion binding]; other site
715451010387	[2Fe-2S] cluster binding site [ion binding]; other site
715451010388	C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880
715451010389	putative alpha subunit interface [polypeptide binding]; other site
715451010390	putative active site [active]
715451010391	putative substrate binding site [chemical binding]; other site
715451010392	Fe binding site [ion binding]; other site
715451010393	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
715451010394	inter-subunit interface; other site
715451010395	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
715451010396	[2Fe-2S] cluster binding site [ion binding]; other site
715451010397	FMN reductase; Validated; Region: fre; PRK08051
715451010398	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
715451010399	FAD binding pocket [chemical binding]; other site
715451010400	FAD binding motif [chemical binding]; other site
715451010401	phosphate binding motif [ion binding]; other site
715451010402	beta-alpha-beta structure motif; other site
715451010403	NAD binding pocket [chemical binding]; other site
715451010404	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
715451010405	dimerization interface [polypeptide binding]; other site
715451010406	substrate binding site [chemical binding]; other site
715451010407	active site
715451010408	calcium binding site [ion binding]; other site
715451010409	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
715451010410	multidrug efflux protein; Reviewed; Region: PRK09579
715451010411	potential frameshift: common BLAST hit: gi|196157754|ref|YP_002127243.1| transposase Tn3
715451010412	potential frameshift: common BLAST hit: gi|229608821|ref|YP_002879469.1| transposase Tn3 family protein
715451010413	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
715451010414	active site
715451010415	catalytic site [active]
715451010416	substrate binding site [chemical binding]; other site
715451010417	potential frameshift: common BLAST hit: gi|196157754|ref|YP_002127243.1| transposase Tn3
715451010418	potential frameshift: common BLAST hit: gi|196157754|ref|YP_002127243.1| transposase Tn3
715451010419	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
715451010420	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
715451010421	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
715451010422	dimerization interface [polypeptide binding]; other site
715451010423	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
715451010424	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
715451010425	dimer interface [polypeptide binding]; other site
715451010426	putative CheW interface [polypeptide binding]; other site
715451010427	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
715451010428	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
715451010429	putative C-terminal domain interface [polypeptide binding]; other site
715451010430	putative GSH binding site (G-site) [chemical binding]; other site
715451010431	putative dimer interface [polypeptide binding]; other site
715451010432	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
715451010433	dimer interface [polypeptide binding]; other site
715451010434	substrate binding pocket (H-site) [chemical binding]; other site
715451010435	Uncharacterized conserved protein [Function unknown]; Region: COG0397
715451010436	hypothetical protein; Validated; Region: PRK00029
715451010437	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
715451010438	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
715451010439	PAS domain; Region: PAS_9; pfam13426
715451010440	putative active site [active]
715451010441	heme pocket [chemical binding]; other site
715451010442	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451010443	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451010444	metal binding site [ion binding]; metal-binding site
715451010445	active site
715451010446	I-site; other site
715451010447	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451010448	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
715451010449	dimerization interface [polypeptide binding]; other site
715451010450	active site
715451010451	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
715451010452	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
715451010453	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
715451010454	Cl binding site [ion binding]; other site
715451010455	oligomer interface [polypeptide binding]; other site
715451010456	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
715451010457	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
715451010458	dimer interface [polypeptide binding]; other site
715451010459	putative CheW interface [polypeptide binding]; other site
715451010460	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
715451010461	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
715451010462	putative active site [active]
715451010463	Zn binding site [ion binding]; other site
715451010464	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
715451010465	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
715451010466	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
715451010467	Protein of unknown function (DUF524); Region: DUF524; pfam04411
715451010468	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
715451010469	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
715451010470	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
715451010471	Serine hydrolase; Region: Ser_hydrolase; cl17834
715451010472	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
715451010473	Protein export membrane protein; Region: SecD_SecF; cl14618
715451010474	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
715451010475	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
715451010476	DNA-J related protein; Region: DNAJ_related; pfam12339
715451010477	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
715451010478	HSP70 interaction site [polypeptide binding]; other site
715451010479	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
715451010480	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
715451010481	Lysine efflux permease [General function prediction only]; Region: COG1279
715451010482	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
715451010483	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451010484	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
715451010485	dimerization interface [polypeptide binding]; other site
715451010486	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
715451010487	Tetratricopeptide repeat; Region: TPR_12; pfam13424
715451010488	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451010489	TPR motif; other site
715451010490	binding surface
715451010491	Tetratricopeptide repeat; Region: TPR_12; pfam13424
715451010492	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451010493	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451010494	metal binding site [ion binding]; metal-binding site
715451010495	active site
715451010496	I-site; other site
715451010497	Protein of unknown function (DUF3034); Region: DUF3034; pfam11231
715451010498	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
715451010499	apolar tunnel; other site
715451010500	heme binding site [chemical binding]; other site
715451010501	dimerization interface [polypeptide binding]; other site
715451010502	sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273
715451010503	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
715451010504	Mechanosensitive ion channel; Region: MS_channel; pfam00924
715451010505	Transcriptional regulators [Transcription]; Region: MarR; COG1846
715451010506	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
715451010507	Predicted amidohydrolase [General function prediction only]; Region: COG0388
715451010508	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
715451010509	active site
715451010510	catalytic triad [active]
715451010511	dimer interface [polypeptide binding]; other site
715451010512	Predicted flavoproteins [General function prediction only]; Region: COG2081
715451010513	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
715451010514	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
715451010515	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
715451010516	Walker A/P-loop; other site
715451010517	ATP binding site [chemical binding]; other site
715451010518	Q-loop/lid; other site
715451010519	ABC transporter signature motif; other site
715451010520	Walker B; other site
715451010521	D-loop; other site
715451010522	H-loop/switch region; other site
715451010523	TOBE domain; Region: TOBE_2; pfam08402
715451010524	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
715451010525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
715451010526	dimer interface [polypeptide binding]; other site
715451010527	conserved gate region; other site
715451010528	putative PBP binding loops; other site
715451010529	ABC-ATPase subunit interface; other site
715451010530	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
715451010531	dimer interface [polypeptide binding]; other site
715451010532	conserved gate region; other site
715451010533	putative PBP binding loops; other site
715451010534	ABC-ATPase subunit interface; other site
715451010535	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
715451010536	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
715451010537	catalytic triad [active]
715451010538	dimer interface [polypeptide binding]; other site
715451010539	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451010540	S-adenosylmethionine binding site [chemical binding]; other site
715451010541	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
715451010542	Y-family of DNA polymerases; Region: PolY; cl12025
715451010543	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
715451010544	ssDNA binding site; other site
715451010545	generic binding surface II; other site
715451010546	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
715451010547	ATP binding site [chemical binding]; other site
715451010548	putative Mg++ binding site [ion binding]; other site
715451010549	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451010550	nucleotide binding region [chemical binding]; other site
715451010551	ATP-binding site [chemical binding]; other site
715451010552	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
715451010553	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
715451010554	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
715451010555	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
715451010556	homotrimer interaction site [polypeptide binding]; other site
715451010557	putative active site [active]
715451010558	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
715451010559	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
715451010560	Zn2+ binding site [ion binding]; other site
715451010561	Mg2+ binding site [ion binding]; other site
715451010562	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
715451010563	synthetase active site [active]
715451010564	NTP binding site [chemical binding]; other site
715451010565	metal binding site [ion binding]; metal-binding site
715451010566	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
715451010567	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
715451010568	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
715451010569	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
715451010570	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
715451010571	catalytic site [active]
715451010572	G-X2-G-X-G-K; other site
715451010573	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
715451010574	putative hydrolase; Provisional; Region: PRK11460
715451010575	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451010576	metal binding site [ion binding]; metal-binding site
715451010577	active site
715451010578	I-site; other site
715451010579	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
715451010580	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
715451010581	domain interfaces; other site
715451010582	active site
715451010583	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
715451010584	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
715451010585	active site
715451010586	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
715451010587	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
715451010588	HemY protein N-terminus; Region: HemY_N; pfam07219
715451010589	phenylhydantoinase; Validated; Region: PRK08323
715451010590	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
715451010591	tetramer interface [polypeptide binding]; other site
715451010592	active site
715451010593	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
715451010594	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
715451010595	Na binding site [ion binding]; other site
715451010596	putative substrate binding site [chemical binding]; other site
715451010597	allantoate amidohydrolase; Reviewed; Region: PRK09290
715451010598	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
715451010599	active site
715451010600	metal binding site [ion binding]; metal-binding site
715451010601	dimer interface [polypeptide binding]; other site
715451010602	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
715451010603	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
715451010604	tetrameric interface [polypeptide binding]; other site
715451010605	NAD binding site [chemical binding]; other site
715451010606	catalytic residues [active]
715451010607	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
715451010608	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
715451010609	inhibitor-cofactor binding pocket; inhibition site
715451010610	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451010611	catalytic residue [active]
715451010612	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451010613	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451010614	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
715451010615	dimerization interface [polypeptide binding]; other site
715451010616	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
715451010617	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451010618	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
715451010619	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit; Region: F420_cofG; TIGR03550
715451010620	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
715451010621	FeS/SAM binding site; other site
715451010622	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
715451010623	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Region: F420_cofH; TIGR03551
715451010624	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
715451010625	FeS/SAM binding site; other site
715451010626	LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186
715451010627	phosphate binding site [ion binding]; other site
715451010628	dimer interface [polypeptide binding]; other site
715451010629	substrate binding site [chemical binding]; other site
715451010630	2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552
715451010631	GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478
715451010632	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
715451010633	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
715451010634	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
715451010635	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
715451010636	F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842
715451010637	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451010638	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451010639	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
715451010640	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
715451010641	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
715451010642	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
715451010643	ThiC-associated domain; Region: ThiC-associated; pfam13667
715451010644	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
715451010645	HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898
715451010646	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
715451010647	substrate binding site [chemical binding]; other site
715451010648	ATP binding site [chemical binding]; other site
715451010649	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
715451010650	thiamine phosphate binding site [chemical binding]; other site
715451010651	active site
715451010652	pyrophosphate binding site [ion binding]; other site
715451010653	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
715451010654	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
715451010655	ATP binding site [chemical binding]; other site
715451010656	substrate interface [chemical binding]; other site
715451010657	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
715451010658	thiS-thiF/thiG interaction site; other site
715451010659	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
715451010660	ThiS interaction site; other site
715451010661	putative active site [active]
715451010662	tetramer interface [polypeptide binding]; other site
715451010663	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
715451010664	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
715451010665	FeS/SAM binding site; other site
715451010666	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
715451010667	YHYH protein; Region: YHYH; pfam14240
715451010668	Uncharacterized conserved protein [Function unknown]; Region: COG2966
715451010669	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
715451010670	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
715451010671	Domain of unknown function (DUF697); Region: DUF697; pfam05128
715451010672	YcjX-like family, DUF463; Region: DUF463; cl01193
715451010673	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
715451010674	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
715451010675	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451010676	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451010677	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
715451010678	substrate binding pocket [chemical binding]; other site
715451010679	dimerization interface [polypeptide binding]; other site
715451010680	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
715451010681	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
715451010682	active site
715451010683	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
715451010684	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
715451010685	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
715451010686	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
715451010687	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
715451010688	Walker A/P-loop; other site
715451010689	ATP binding site [chemical binding]; other site
715451010690	Q-loop/lid; other site
715451010691	ABC transporter signature motif; other site
715451010692	Walker B; other site
715451010693	D-loop; other site
715451010694	H-loop/switch region; other site
715451010695	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
715451010696	Walker A/P-loop; other site
715451010697	ATP binding site [chemical binding]; other site
715451010698	Q-loop/lid; other site
715451010699	ABC transporter signature motif; other site
715451010700	Walker B; other site
715451010701	D-loop; other site
715451010702	H-loop/switch region; other site
715451010703	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
715451010704	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
715451010705	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
715451010706	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451010707	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
715451010708	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
715451010709	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
715451010710	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
715451010711	tetrameric interface [polypeptide binding]; other site
715451010712	NAD binding site [chemical binding]; other site
715451010713	catalytic residues [active]
715451010714	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451010715	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451010716	LysR substrate binding domain; Region: LysR_substrate; pfam03466
715451010717	dimerization interface [polypeptide binding]; other site
715451010718	ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003
715451010719	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451010720	N-terminal plug; other site
715451010721	ligand-binding site [chemical binding]; other site
715451010722	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451010723	dimer interface [polypeptide binding]; other site
715451010724	phosphorylation site [posttranslational modification]
715451010725	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451010726	ATP binding site [chemical binding]; other site
715451010727	Mg2+ binding site [ion binding]; other site
715451010728	G-X-G motif; other site
715451010729	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451010730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451010731	active site
715451010732	phosphorylation site [posttranslational modification]
715451010733	intermolecular recognition site; other site
715451010734	dimerization interface [polypeptide binding]; other site
715451010735	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
715451010736	L-lactate permease; Region: Lactate_perm; cl00701
715451010737	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
715451010738	PLD-like domain; Region: PLDc_2; pfam13091
715451010739	putative active site [active]
715451010740	catalytic site [active]
715451010741	DEAD-like helicases superfamily; Region: DEXDc; smart00487
715451010742	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
715451010743	ATP binding site [chemical binding]; other site
715451010744	putative Mg++ binding site [ion binding]; other site
715451010745	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451010746	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
715451010747	nucleotide binding region [chemical binding]; other site
715451010748	ATP-binding site [chemical binding]; other site
715451010749	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
715451010750	Catalytic site [active]
715451010751	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
715451010752	Restriction endonuclease; Region: Mrr_cat; pfam04471
715451010753	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
715451010754	BCCT family transporter; Region: BCCT; pfam02028
715451010755	Protein of unknown function (DUF2960); Region: DUF2960; pfam11173
715451010756	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
715451010757	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
715451010758	non-specific DNA binding site [nucleotide binding]; other site
715451010759	salt bridge; other site
715451010760	sequence-specific DNA binding site [nucleotide binding]; other site
715451010761	HipA N-terminal domain; Region: Couple_hipA; cl11853
715451010762	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
715451010763	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
715451010764	GAF domain; Region: GAF; cl17456
715451010765	GAF domain; Region: GAF; pfam01590
715451010766	GAF domain; Region: GAF_2; pfam13185
715451010767	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451010768	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451010769	metal binding site [ion binding]; metal-binding site
715451010770	active site
715451010771	I-site; other site
715451010772	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451010773	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
715451010774	Part of AAA domain; Region: AAA_19; pfam13245
715451010775	Family description; Region: UvrD_C_2; pfam13538
715451010776	Membrane fusogenic activity; Region: BMFP; pfam04380
715451010777	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
715451010778	UbiA prenyltransferase family; Region: UbiA; pfam01040
715451010779	Chorismate lyase; Region: Chor_lyase; cl01230
715451010780	flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697
715451010781	rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239
715451010782	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
715451010783	Rhomboid family; Region: Rhomboid; pfam01694
715451010784	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
715451010785	active site residue [active]
715451010786	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
715451010787	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
715451010788	NAD(P) binding site [chemical binding]; other site
715451010789	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
715451010790	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
715451010791	substrate-cofactor binding pocket; other site
715451010792	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451010793	catalytic residue [active]
715451010794	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451010795	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451010796	metal binding site [ion binding]; metal-binding site
715451010797	active site
715451010798	I-site; other site
715451010799	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451010800	PBP superfamily domain; Region: PBP_like_2; cl17296
715451010801	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
715451010802	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
715451010803	putative active site [active]
715451010804	3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723
715451010805	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
715451010806	active site
715451010807	ATP binding site [chemical binding]; other site
715451010808	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
715451010809	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
715451010810	active site
715451010811	(T/H)XGH motif; other site
715451010812	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
715451010813	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
715451010814	DNA binding site [nucleotide binding]
715451010815	catalytic residue [active]
715451010816	H2TH interface [polypeptide binding]; other site
715451010817	putative catalytic residues [active]
715451010818	turnover-facilitating residue; other site
715451010819	intercalation triad [nucleotide binding]; other site
715451010820	8OG recognition residue [nucleotide binding]; other site
715451010821	putative reading head residues; other site
715451010822	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
715451010823	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
715451010824	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
715451010825	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
715451010826	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
715451010827	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
715451010828	active site
715451010829	HIGH motif; other site
715451010830	nucleotide binding site [chemical binding]; other site
715451010831	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
715451010832	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
715451010833	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
715451010834	hypothetical protein; Reviewed; Region: PRK00024
715451010835	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
715451010836	MPN+ (JAMM) motif; other site
715451010837	Zinc-binding site [ion binding]; other site
715451010838	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
715451010839	Flavoprotein; Region: Flavoprotein; pfam02441
715451010840	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
715451010841	division inhibitor protein; Provisional; Region: slmA; PRK09480
715451010842	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451010843	Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316
715451010844	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
715451010845	PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820
715451010846	PA/protease or protease-like domain interface [polypeptide binding]; other site
715451010847	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661
715451010848	Peptidase family M28; Region: Peptidase_M28; pfam04389
715451010849	metal binding site [ion binding]; metal-binding site
715451010850	Domain of unknown function (DUF1820); Region: DUF1820; pfam08850
715451010851	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
715451010852	Uncharacterized conserved protein [Function unknown]; Region: COG4544
715451010853	DNA Polymerase Y-family; Region: PolY_like; cd03468
715451010854	active site
715451010855	DNA binding site [nucleotide binding]
715451010856	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
715451010857	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
715451010858	putative active site [active]
715451010859	putative PHP Thumb interface [polypeptide binding]; other site
715451010860	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
715451010861	generic binding surface II; other site
715451010862	generic binding surface I; other site
715451010863	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
715451010864	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
715451010865	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
715451010866	Outer membrane efflux protein; Region: OEP; pfam02321
715451010867	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
715451010868	E3 interaction surface; other site
715451010869	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451010870	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
715451010871	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
715451010872	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451010873	Q-loop/lid; other site
715451010874	ABC transporter signature motif; other site
715451010875	Walker B; other site
715451010876	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451010877	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
715451010878	dimerization interface [polypeptide binding]; other site
715451010879	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
715451010880	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
715451010881	Substrate binding site; other site
715451010882	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
715451010883	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
715451010884	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
715451010885	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
715451010886	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
715451010887	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
715451010888	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
715451010889	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
715451010890	Probable Catalytic site; other site
715451010891	metal-binding site
715451010892	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
715451010893	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
715451010894	NAD binding site [chemical binding]; other site
715451010895	substrate binding site [chemical binding]; other site
715451010896	homodimer interface [polypeptide binding]; other site
715451010897	active site
715451010898	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
715451010899	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
715451010900	NADP binding site [chemical binding]; other site
715451010901	active site
715451010902	putative substrate binding site [chemical binding]; other site
715451010903	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
715451010904	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
715451010905	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
715451010906	substrate binding site; other site
715451010907	tetramer interface; other site
715451010908	kelch-like protein; Provisional; Region: PHA03098
715451010909	Protein of unknown function (DUF563); Region: DUF563; pfam04577
715451010910	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
715451010911	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
715451010912	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
715451010913	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
715451010914	Methyltransferase domain; Region: Methyltransf_23; pfam13489
715451010915	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451010916	S-adenosylmethionine binding site [chemical binding]; other site
715451010917	Methyltransferase domain; Region: Methyltransf_24; pfam13578
715451010918	GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183
715451010919	Ligand binding site; other site
715451010920	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
715451010921	active site
715451010922	capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689
715451010923	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
715451010924	putative trimer interface [polypeptide binding]; other site
715451010925	putative CoA binding site [chemical binding]; other site
715451010926	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
715451010927	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
715451010928	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
715451010929	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
715451010930	Probable Catalytic site; other site
715451010931	metal-binding site
715451010932	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
715451010933	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
715451010934	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
715451010935	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
715451010936	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
715451010937	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
715451010938	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
715451010939	Right handed beta helix region; Region: Beta_helix; pfam13229
715451010940	Right handed beta helix region; Region: Beta_helix; pfam13229
715451010941	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
715451010942	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
715451010943	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
715451010944	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
715451010945	Rhamnan synthesis protein F; Region: RgpF; pfam05045
715451010946	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
715451010947	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
715451010948	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
715451010949	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
715451010950	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
715451010951	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
715451010952	alphaNTD homodimer interface [polypeptide binding]; other site
715451010953	alphaNTD - beta interaction site [polypeptide binding]; other site
715451010954	alphaNTD - beta' interaction site [polypeptide binding]; other site
715451010955	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
715451010956	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
715451010957	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
715451010958	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
715451010959	RNA binding surface [nucleotide binding]; other site
715451010960	30S ribosomal protein S11; Validated; Region: PRK05309
715451010961	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
715451010962	30S ribosomal protein S13; Region: bact_S13; TIGR03631
715451010963	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
715451010964	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
715451010965	SecY translocase; Region: SecY; pfam00344
715451010966	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
715451010967	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
715451010968	23S rRNA binding site [nucleotide binding]; other site
715451010969	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
715451010970	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
715451010971	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
715451010972	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
715451010973	5S rRNA interface [nucleotide binding]; other site
715451010974	23S rRNA interface [nucleotide binding]; other site
715451010975	L5 interface [polypeptide binding]; other site
715451010976	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
715451010977	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
715451010978	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
715451010979	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
715451010980	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
715451010981	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
715451010982	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
715451010983	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
715451010984	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
715451010985	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
715451010986	RNA binding site [nucleotide binding]; other site
715451010987	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
715451010988	PAS domain S-box; Region: sensory_box; TIGR00229
715451010989	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451010990	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451010991	dimer interface [polypeptide binding]; other site
715451010992	phosphorylation site [posttranslational modification]
715451010993	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451010994	ATP binding site [chemical binding]; other site
715451010995	Mg2+ binding site [ion binding]; other site
715451010996	G-X-G motif; other site
715451010997	Response regulator receiver domain; Region: Response_reg; pfam00072
715451010998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451010999	active site
715451011000	phosphorylation site [posttranslational modification]
715451011001	intermolecular recognition site; other site
715451011002	dimerization interface [polypeptide binding]; other site
715451011003	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
715451011004	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
715451011005	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
715451011006	active site
715451011007	catalytic residues [active]
715451011008	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
715451011009	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
715451011010	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
715451011011	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
715451011012	ribonuclease R; Region: RNase_R; TIGR02063
715451011013	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
715451011014	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
715451011015	RNB domain; Region: RNB; pfam00773
715451011016	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
715451011017	RNA binding site [nucleotide binding]; other site
715451011018	PhoD-like phosphatase; Region: PhoD; pfam09423
715451011019	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
715451011020	putative active site [active]
715451011021	putative metal binding site [ion binding]; other site
715451011022	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
715451011023	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451011024	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
715451011025	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451011026	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
715451011027	Phosphate-starvation-inducible E; Region: PsiE; cl01264
715451011028	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
715451011029	FMN reductase; Validated; Region: fre; PRK08051
715451011030	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
715451011031	FAD binding pocket [chemical binding]; other site
715451011032	FAD binding motif [chemical binding]; other site
715451011033	phosphate binding motif [ion binding]; other site
715451011034	beta-alpha-beta structure motif; other site
715451011035	NAD binding pocket [chemical binding]; other site
715451011036	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642
715451011037	Peptidase family M28; Region: Peptidase_M28; pfam04389
715451011038	putative metal binding site [ion binding]; other site
715451011039	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
715451011040	Interdomain contacts; other site
715451011041	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
715451011042	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
715451011043	substrate binding pocket [chemical binding]; other site
715451011044	membrane-bound complex binding site; other site
715451011045	hinge residues; other site
715451011046	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
715451011047	Predicted transcriptional regulators [Transcription]; Region: COG1510
715451011048	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
715451011049	putative DNA binding site [nucleotide binding]; other site
715451011050	putative Zn2+ binding site [ion binding]; other site
715451011051	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
715451011052	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
715451011053	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
715451011054	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
715451011055	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
715451011056	dimer interface [polypeptide binding]; other site
715451011057	putative CheW interface [polypeptide binding]; other site
715451011058	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
715451011059	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
715451011060	putative DNA binding site [nucleotide binding]; other site
715451011061	putative Zn2+ binding site [ion binding]; other site
715451011062	AsnC family; Region: AsnC_trans_reg; pfam01037
715451011063	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
715451011064	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
715451011065	dimer interface [polypeptide binding]; other site
715451011066	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451011067	catalytic residue [active]
715451011068	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
715451011069	DNA-binding site [nucleotide binding]; DNA binding site
715451011070	RNA-binding motif; other site
715451011071	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
715451011072	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
715451011073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
715451011074	SCP-2 sterol transfer family; Region: SCP2; pfam02036
715451011075	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
715451011076	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451011077	S-adenosylmethionine binding site [chemical binding]; other site
715451011078	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
715451011079	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
715451011080	oligopeptidase A; Provisional; Region: PRK10911
715451011081	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
715451011082	active site
715451011083	Zn binding site [ion binding]; other site
715451011084	Helix-turn-helix domain; Region: HTH_17; pfam12728
715451011085	Response regulator receiver domain; Region: Response_reg; pfam00072
715451011086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451011087	active site
715451011088	phosphorylation site [posttranslational modification]
715451011089	intermolecular recognition site; other site
715451011090	dimerization interface [polypeptide binding]; other site
715451011091	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
715451011092	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
715451011093	dimerization interface [polypeptide binding]; other site
715451011094	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
715451011095	dimerization interface [polypeptide binding]; other site
715451011096	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451011097	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451011098	ATP binding site [chemical binding]; other site
715451011099	Mg2+ binding site [ion binding]; other site
715451011100	G-X-G motif; other site
715451011101	Response regulator receiver domain; Region: Response_reg; pfam00072
715451011102	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451011103	active site
715451011104	phosphorylation site [posttranslational modification]
715451011105	intermolecular recognition site; other site
715451011106	dimerization interface [polypeptide binding]; other site
715451011107	HD domain; Region: HD_5; pfam13487
715451011108	glutathione reductase; Validated; Region: PRK06116
715451011109	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
715451011110	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
715451011111	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
715451011112	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
715451011113	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
715451011114	putative [Fe4-S4] binding site [ion binding]; other site
715451011115	putative molybdopterin cofactor binding site [chemical binding]; other site
715451011116	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
715451011117	putative molybdopterin cofactor binding site; other site
715451011118	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
715451011119	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
715451011120	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
715451011121	Amidohydrolase; Region: Amidohydro_5; pfam13594
715451011122	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
715451011123	active site
715451011124	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
715451011125	potential frameshift: common BLAST hit: gi|196158305|ref|YP_002127794.1| hydroxymethylglutaryl-coenzyme A reductase
715451011126	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
715451011127	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
715451011128	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451011129	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
715451011130	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
715451011131	putative active site [active]
715451011132	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
715451011133	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
715451011134	Walker A/P-loop; other site
715451011135	ATP binding site [chemical binding]; other site
715451011136	Q-loop/lid; other site
715451011137	ABC transporter signature motif; other site
715451011138	Walker B; other site
715451011139	D-loop; other site
715451011140	H-loop/switch region; other site
715451011141	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
715451011142	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
715451011143	DNA binding residues [nucleotide binding]
715451011144	dimerization interface [polypeptide binding]; other site
715451011145	ATP-grasp domain; Region: ATP-grasp_4; cl17255
715451011146	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
715451011147	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451011148	Walker A motif; other site
715451011149	ATP binding site [chemical binding]; other site
715451011150	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
715451011151	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
715451011152	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
715451011153	active site
715451011154	HslU subunit interaction site [polypeptide binding]; other site
715451011155	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
715451011156	Sporulation related domain; Region: SPOR; pfam05036
715451011157	primosome assembly protein PriA; Validated; Region: PRK05580
715451011158	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
715451011159	ATP binding site [chemical binding]; other site
715451011160	putative Mg++ binding site [ion binding]; other site
715451011161	helicase superfamily c-terminal domain; Region: HELICc; smart00490
715451011162	ATP-binding site [chemical binding]; other site
715451011163	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
715451011164	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
715451011165	Malic enzyme, N-terminal domain; Region: malic; pfam00390
715451011166	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
715451011167	putative NAD(P) binding site [chemical binding]; other site
715451011168	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
715451011169	dimerization interface [polypeptide binding]; other site
715451011170	DNA binding site [nucleotide binding]
715451011171	corepressor binding sites; other site
715451011172	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
715451011173	FAD binding site [chemical binding]; other site
715451011174	hypothetical protein; Reviewed; Region: PRK01637
715451011175	Protein of unknown function (DUF2959); Region: DUF2959; pfam11172
715451011176	CobD/Cbib protein; Region: CobD_Cbib; cl00561
715451011177	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
715451011178	TAP-like protein; Region: Abhydrolase_4; pfam08386
715451011179	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
715451011180	putative active site [active]
715451011181	dimerization interface [polypeptide binding]; other site
715451011182	putative tRNAtyr binding site [nucleotide binding]; other site
715451011183	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
715451011184	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
715451011185	Coenzyme A binding pocket [chemical binding]; other site
715451011186	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
715451011187	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
715451011188	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451011189	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
715451011190	DNA binding residues [nucleotide binding]
715451011191	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
715451011192	EAL domain; Region: EAL; pfam00563
715451011193	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
715451011194	EAL domain; Region: EAL; pfam00563
715451011195	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
715451011196	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
715451011197	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
715451011198	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451011199	Walker A/P-loop; other site
715451011200	ATP binding site [chemical binding]; other site
715451011201	Q-loop/lid; other site
715451011202	ABC transporter signature motif; other site
715451011203	Walker B; other site
715451011204	D-loop; other site
715451011205	H-loop/switch region; other site
715451011206	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
715451011207	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
715451011208	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
715451011209	P loop; other site
715451011210	GTP binding site [chemical binding]; other site
715451011211	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
715451011212	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
715451011213	Protein of unknown function (DUF416); Region: DUF416; pfam04222
715451011214	MarC family integral membrane protein; Region: MarC; cl00919
715451011215	Peptidase; Region: DUF3663; pfam12404
715451011216	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
715451011217	interface (dimer of trimers) [polypeptide binding]; other site
715451011218	Substrate-binding/catalytic site; other site
715451011219	Zn-binding sites [ion binding]; other site
715451011220	Peptidase; Region: DUF3663; pfam12404
715451011221	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
715451011222	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
715451011223	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
715451011224	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
715451011225	active site
715451011226	HIGH motif; other site
715451011227	nucleotide binding site [chemical binding]; other site
715451011228	active site
715451011229	KMSKS motif; other site
715451011230	poly(A) polymerase; Region: pcnB; TIGR01942
715451011231	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
715451011232	active site
715451011233	NTP binding site [chemical binding]; other site
715451011234	metal binding triad [ion binding]; metal-binding site
715451011235	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
715451011236	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
715451011237	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
715451011238	catalytic center binding site [active]
715451011239	ATP binding site [chemical binding]; other site
715451011240	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
715451011241	oligomerization interface [polypeptide binding]; other site
715451011242	active site
715451011243	metal binding site [ion binding]; metal-binding site
715451011244	pantoate--beta-alanine ligase; Region: panC; TIGR00018
715451011245	Pantoate-beta-alanine ligase; Region: PanC; cd00560
715451011246	active site
715451011247	ATP-binding site [chemical binding]; other site
715451011248	pantoate-binding site; other site
715451011249	HXXH motif; other site
715451011250	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
715451011251	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
715451011252	catalytic residue [active]
715451011253	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451011254	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
715451011255	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451011256	S-adenosylmethionine binding site [chemical binding]; other site
715451011257	inner membrane transport permease; Provisional; Region: PRK15066
715451011258	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
715451011259	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
715451011260	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
715451011261	Walker A/P-loop; other site
715451011262	ATP binding site [chemical binding]; other site
715451011263	Q-loop/lid; other site
715451011264	ABC transporter signature motif; other site
715451011265	Walker B; other site
715451011266	D-loop; other site
715451011267	H-loop/switch region; other site
715451011268	proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787
715451011269	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451011270	active site
715451011271	phosphorylation site [posttranslational modification]
715451011272	intermolecular recognition site; other site
715451011273	dimerization interface [polypeptide binding]; other site
715451011274	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451011275	DNA binding site [nucleotide binding]
715451011276	proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785
715451011277	DOMON-like type 9 carbohydrate binding module at the N-terminus of bacterial sensor histidine kinases; Region: CBM9_like_HisKa; cd09622
715451011278	putative ligand binding site [chemical binding]; other site
715451011279	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
715451011280	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451011281	dimer interface [polypeptide binding]; other site
715451011282	phosphorylation site [posttranslational modification]
715451011283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451011284	ATP binding site [chemical binding]; other site
715451011285	Mg2+ binding site [ion binding]; other site
715451011286	G-X-G motif; other site
715451011287	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
715451011288	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451011289	N-terminal plug; other site
715451011290	ligand-binding site [chemical binding]; other site
715451011291	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
715451011292	Domain of unknown function DUF21; Region: DUF21; pfam01595
715451011293	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
715451011294	Predicted permeases [General function prediction only]; Region: COG0701
715451011295	Carbon starvation protein CstA; Region: CstA; pfam02554
715451011296	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
715451011297	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
715451011298	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
715451011299	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494
715451011300	Na binding site [ion binding]; other site
715451011301	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
715451011302	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
715451011303	Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classI; cd00643
715451011304	tetramerization interface [polypeptide binding]; other site
715451011305	substrate binding pocket [chemical binding]; other site
715451011306	catalytic residues [active]
715451011307	inhibitor binding sites; inhibition site
715451011308	NADP(H) binding site [chemical binding]; other site
715451011309	elongation factor Tu; Reviewed; Region: PRK00049
715451011310	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
715451011311	G1 box; other site
715451011312	GEF interaction site [polypeptide binding]; other site
715451011313	GTP/Mg2+ binding site [chemical binding]; other site
715451011314	Switch I region; other site
715451011315	G2 box; other site
715451011316	G3 box; other site
715451011317	Switch II region; other site
715451011318	G4 box; other site
715451011319	G5 box; other site
715451011320	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
715451011321	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
715451011322	Antibiotic Binding Site [chemical binding]; other site
715451011323	elongation factor G; Reviewed; Region: PRK00007
715451011324	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
715451011325	G1 box; other site
715451011326	putative GEF interaction site [polypeptide binding]; other site
715451011327	GTP/Mg2+ binding site [chemical binding]; other site
715451011328	Switch I region; other site
715451011329	G2 box; other site
715451011330	G3 box; other site
715451011331	Switch II region; other site
715451011332	G4 box; other site
715451011333	G5 box; other site
715451011334	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
715451011335	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
715451011336	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
715451011337	30S ribosomal protein S7; Validated; Region: PRK05302
715451011338	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
715451011339	S17 interaction site [polypeptide binding]; other site
715451011340	S8 interaction site; other site
715451011341	16S rRNA interaction site [nucleotide binding]; other site
715451011342	streptomycin interaction site [chemical binding]; other site
715451011343	23S rRNA interaction site [nucleotide binding]; other site
715451011344	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
715451011345	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
715451011346	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
715451011347	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
715451011348	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
715451011349	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
715451011350	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
715451011351	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
715451011352	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
715451011353	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
715451011354	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
715451011355	DNA binding site [nucleotide binding]
715451011356	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
715451011357	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
715451011358	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
715451011359	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
715451011360	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
715451011361	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
715451011362	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
715451011363	RPB3 interaction site [polypeptide binding]; other site
715451011364	RPB1 interaction site [polypeptide binding]; other site
715451011365	RPB11 interaction site [polypeptide binding]; other site
715451011366	RPB10 interaction site [polypeptide binding]; other site
715451011367	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
715451011368	core dimer interface [polypeptide binding]; other site
715451011369	peripheral dimer interface [polypeptide binding]; other site
715451011370	L10 interface [polypeptide binding]; other site
715451011371	L11 interface [polypeptide binding]; other site
715451011372	putative EF-Tu interaction site [polypeptide binding]; other site
715451011373	putative EF-G interaction site [polypeptide binding]; other site
715451011374	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
715451011375	23S rRNA interface [nucleotide binding]; other site
715451011376	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
715451011377	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
715451011378	mRNA/rRNA interface [nucleotide binding]; other site
715451011379	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
715451011380	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
715451011381	23S rRNA interface [nucleotide binding]; other site
715451011382	L7/L12 interface [polypeptide binding]; other site
715451011383	putative thiostrepton binding site; other site
715451011384	L25 interface [polypeptide binding]; other site
715451011385	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
715451011386	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
715451011387	putative homodimer interface [polypeptide binding]; other site
715451011388	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
715451011389	heterodimer interface [polypeptide binding]; other site
715451011390	homodimer interface [polypeptide binding]; other site
715451011391	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
715451011392	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
715451011393	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
715451011394	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
715451011395	Walker A/P-loop; other site
715451011396	ATP binding site [chemical binding]; other site
715451011397	Q-loop/lid; other site
715451011398	ABC transporter signature motif; other site
715451011399	Walker B; other site
715451011400	D-loop; other site
715451011401	H-loop/switch region; other site
715451011402	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
715451011403	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
715451011404	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
715451011405	active site
715451011406	Zn binding site [ion binding]; other site
715451011407	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
715451011408	ACT domain; Region: ACT_3; pfam10000
715451011409	Family description; Region: ACT_7; pfam13840
715451011410	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
715451011411	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
715451011412	ATP binding site [chemical binding]; other site
715451011413	Mg++ binding site [ion binding]; other site
715451011414	motif III; other site
715451011415	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451011416	nucleotide binding region [chemical binding]; other site
715451011417	ATP-binding site [chemical binding]; other site
715451011418	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
715451011419	putative RNA binding site [nucleotide binding]; other site
715451011420	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
715451011421	active site
715451011422	substrate binding pocket [chemical binding]; other site
715451011423	dimer interface [polypeptide binding]; other site
715451011424	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782
715451011425	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
715451011426	PhnA protein; Region: PhnA; pfam03831
715451011427	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
715451011428	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
715451011429	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
715451011430	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
715451011431	active site
715451011432	catalytic tetrad [active]
715451011433	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
715451011434	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
715451011435	putative metal binding site [ion binding]; other site
715451011436	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
715451011437	GTP cyclohydrolase I; Provisional; Region: PLN03044
715451011438	active site
715451011439	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
715451011440	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
715451011441	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
715451011442	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
715451011443	putative active site; other site
715451011444	catalytic triad [active]
715451011445	putative dimer interface [polypeptide binding]; other site
715451011446	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
715451011447	putative active site [active]
715451011448	putative metal binding site [ion binding]; other site
715451011449	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
715451011450	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
715451011451	ATP binding site [chemical binding]; other site
715451011452	putative Mg++ binding site [ion binding]; other site
715451011453	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451011454	nucleotide binding region [chemical binding]; other site
715451011455	ATP-binding site [chemical binding]; other site
715451011456	DEAD/H associated; Region: DEAD_assoc; pfam08494
715451011457	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
715451011458	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
715451011459	DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120
715451011460	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
715451011461	active site
715451011462	DNA binding site [nucleotide binding]
715451011463	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
715451011464	DNA binding site [nucleotide binding]
715451011465	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
715451011466	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
715451011467	putative substrate binding site [chemical binding]; other site
715451011468	putative ATP binding site [chemical binding]; other site
715451011469	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
715451011470	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
715451011471	non-specific DNA interactions [nucleotide binding]; other site
715451011472	DNA binding site [nucleotide binding]
715451011473	sequence specific DNA binding site [nucleotide binding]; other site
715451011474	putative cAMP binding site [chemical binding]; other site
715451011475	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
715451011476	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
715451011477	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
715451011478	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
715451011479	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
715451011480	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
715451011481	C-terminal domain interface [polypeptide binding]; other site
715451011482	GSH binding site (G-site) [chemical binding]; other site
715451011483	dimer interface [polypeptide binding]; other site
715451011484	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
715451011485	N-terminal domain interface [polypeptide binding]; other site
715451011486	dimer interface [polypeptide binding]; other site
715451011487	substrate binding pocket (H-site) [chemical binding]; other site
715451011488	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
715451011489	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
715451011490	putative C-terminal domain interface [polypeptide binding]; other site
715451011491	putative GSH binding site (G-site) [chemical binding]; other site
715451011492	putative dimer interface [polypeptide binding]; other site
715451011493	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
715451011494	N-terminal domain interface [polypeptide binding]; other site
715451011495	dimer interface [polypeptide binding]; other site
715451011496	substrate binding pocket (H-site) [chemical binding]; other site
715451011497	lipase chaperone; Provisional; Region: PRK01294
715451011498	Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280
715451011499	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
715451011500	Putative serine esterase (DUF676); Region: DUF676; pfam05057
715451011501	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
715451011502	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451011503	S-adenosylmethionine binding site [chemical binding]; other site
715451011504	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467
715451011505	Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147
715451011506	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
715451011507	NAD(P) binding site [chemical binding]; other site
715451011508	catalytic residues [active]
715451011509	acetolactate synthase; Reviewed; Region: PRK08322
715451011510	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
715451011511	PYR/PP interface [polypeptide binding]; other site
715451011512	dimer interface [polypeptide binding]; other site
715451011513	TPP binding site [chemical binding]; other site
715451011514	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
715451011515	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
715451011516	TPP-binding site [chemical binding]; other site
715451011517	dimer interface [polypeptide binding]; other site
715451011518	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
715451011519	ferrochelatase; Reviewed; Region: hemH; PRK00035
715451011520	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
715451011521	C-terminal domain interface [polypeptide binding]; other site
715451011522	active site
715451011523	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
715451011524	active site
715451011525	N-terminal domain interface [polypeptide binding]; other site
715451011526	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
715451011527	AbgT putative transporter family; Region: ABG_transport; pfam03806
715451011528	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
715451011529	FtsH protease regulator HflC; Provisional; Region: PRK11029
715451011530	FtsH protease regulator HflK; Provisional; Region: PRK10930
715451011531	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
715451011532	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
715451011533	GTPase HflX; Provisional; Region: PRK11058
715451011534	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
715451011535	HflX GTPase family; Region: HflX; cd01878
715451011536	G1 box; other site
715451011537	GTP/Mg2+ binding site [chemical binding]; other site
715451011538	Switch I region; other site
715451011539	G2 box; other site
715451011540	G3 box; other site
715451011541	Switch II region; other site
715451011542	G4 box; other site
715451011543	G5 box; other site
715451011544	bacterial Hfq-like; Region: Hfq; cd01716
715451011545	hexamer interface [polypeptide binding]; other site
715451011546	Sm1 motif; other site
715451011547	RNA binding site [nucleotide binding]; other site
715451011548	Sm2 motif; other site
715451011549	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
715451011550	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
715451011551	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
715451011552	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451011553	ATP binding site [chemical binding]; other site
715451011554	Mg2+ binding site [ion binding]; other site
715451011555	G-X-G motif; other site
715451011556	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
715451011557	ATP binding site [chemical binding]; other site
715451011558	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
715451011559	AMIN domain; Region: AMIN; pfam11741
715451011560	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
715451011561	active site
715451011562	metal binding site [ion binding]; metal-binding site
715451011563	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
715451011564	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
715451011565	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
715451011566	putative carbohydrate kinase; Provisional; Region: PRK10565
715451011567	Uncharacterized conserved protein [Function unknown]; Region: COG0062
715451011568	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
715451011569	putative substrate binding site [chemical binding]; other site
715451011570	putative ATP binding site [chemical binding]; other site
715451011571	epoxyqueuosine reductase; Region: TIGR00276
715451011572	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
715451011573	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
715451011574	substrate binding site [chemical binding]; other site
715451011575	active site
715451011576	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
715451011577	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
715451011578	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
715451011579	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
715451011580	putative NADH binding site [chemical binding]; other site
715451011581	putative active site [active]
715451011582	nudix motif; other site
715451011583	putative metal binding site [ion binding]; other site
715451011584	anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718
715451011585	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
715451011586	metal binding site 2 [ion binding]; metal-binding site
715451011587	putative DNA binding helix; other site
715451011588	metal binding site 1 [ion binding]; metal-binding site
715451011589	dimer interface [polypeptide binding]; other site
715451011590	structural Zn2+ binding site [ion binding]; other site
715451011591	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
715451011592	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
715451011593	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
715451011594	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
715451011595	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
715451011596	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
715451011597	ligand binding site [chemical binding]; other site
715451011598	replicative DNA helicase; Region: DnaB; TIGR00665
715451011599	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
715451011600	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
715451011601	Walker A motif; other site
715451011602	ATP binding site [chemical binding]; other site
715451011603	Walker B motif; other site
715451011604	DNA binding loops [nucleotide binding]
715451011605	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
715451011606	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
715451011607	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
715451011608	RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638
715451011609	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451011610	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
715451011611	DNA binding residues [nucleotide binding]
715451011612	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
715451011613	MOSC domain; Region: MOSC; pfam03473
715451011614	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
715451011615	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
715451011616	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451011617	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
715451011618	Protein export membrane protein; Region: SecD_SecF; cl14618
715451011619	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
715451011620	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
715451011621	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
715451011622	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
715451011623	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
715451011624	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451011625	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451011626	dimer interface [polypeptide binding]; other site
715451011627	phosphorylation site [posttranslational modification]
715451011628	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451011629	ATP binding site [chemical binding]; other site
715451011630	Mg2+ binding site [ion binding]; other site
715451011631	G-X-G motif; other site
715451011632	YebG protein; Region: YebG; pfam07130
715451011633	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
715451011634	PAS domain; Region: PAS_9; pfam13426
715451011635	putative active site [active]
715451011636	heme pocket [chemical binding]; other site
715451011637	ATP synthase I chain; Region: ATP_synt_I; cl09170
715451011638	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
715451011639	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
715451011640	dimer interface [polypeptide binding]; other site
715451011641	putative CheW interface [polypeptide binding]; other site
715451011642	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451011643	ATP binding site [chemical binding]; other site
715451011644	Mg2+ binding site [ion binding]; other site
715451011645	G-X-G motif; other site
715451011646	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
715451011647	dimer interface [polypeptide binding]; other site
715451011648	putative CheW interface [polypeptide binding]; other site
715451011649	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
715451011650	Transcriptional regulators [Transcription]; Region: PurR; COG1609
715451011651	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
715451011652	DNA binding site [nucleotide binding]
715451011653	domain linker motif; other site
715451011654	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
715451011655	dimerization interface (closed form) [polypeptide binding]; other site
715451011656	ligand binding site [chemical binding]; other site
715451011657	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
715451011658	putative symporter YagG; Provisional; Region: PRK09669
715451011659	beta-galactosidase; Region: BGL; TIGR03356
715451011660	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
715451011661	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
715451011662	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
715451011663	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
715451011664	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
715451011665	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
715451011666	Walker A/P-loop; other site
715451011667	ATP binding site [chemical binding]; other site
715451011668	Q-loop/lid; other site
715451011669	ABC transporter signature motif; other site
715451011670	Walker B; other site
715451011671	D-loop; other site
715451011672	H-loop/switch region; other site
715451011673	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
715451011674	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
715451011675	ABC-ATPase subunit  interface; other site
715451011676	dimer interface [polypeptide binding]; other site
715451011677	putative PBP binding regions; other site
715451011678	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
715451011679	intersubunit interface [polypeptide binding]; other site
715451011680	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
715451011681	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
715451011682	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
715451011683	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451011684	N-terminal plug; other site
715451011685	ligand-binding site [chemical binding]; other site
715451011686	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
715451011687	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451011688	putative substrate translocation pore; other site
715451011689	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
715451011690	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
715451011691	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
715451011692	quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908
715451011693	sulfite oxidase; Provisional; Region: PLN00177
715451011694	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
715451011695	Moco binding site; other site
715451011696	metal coordination site [ion binding]; other site
715451011697	dimerization interface [polypeptide binding]; other site
715451011698	Predicted membrane protein [Function unknown]; Region: COG2855
715451011699	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
715451011700	substrate binding pocket [chemical binding]; other site
715451011701	active site
715451011702	iron coordination sites [ion binding]; other site
715451011703	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
715451011704	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
715451011705	active site
715451011706	catalytic tetrad [active]
715451011707	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
715451011708	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
715451011709	DNA-binding site [nucleotide binding]; DNA binding site
715451011710	UTRA domain; Region: UTRA; pfam07702
715451011711	alpha-glucosidase; Provisional; Region: PRK10426
715451011712	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
715451011713	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
715451011714	active site
715451011715	catalytic site [active]
715451011716	putative transporter; Provisional; Region: PRK10484
715451011717	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
715451011718	Na binding site [ion binding]; other site
715451011719	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
715451011720	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
715451011721	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
715451011722	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
715451011723	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
715451011724	active site
715451011725	catalytic residues [active]
715451011726	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
715451011727	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451011728	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451011729	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
715451011730	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451011731	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
715451011732	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451011733	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
715451011734	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
715451011735	Walker A/P-loop; other site
715451011736	ATP binding site [chemical binding]; other site
715451011737	Q-loop/lid; other site
715451011738	ABC transporter signature motif; other site
715451011739	Walker B; other site
715451011740	D-loop; other site
715451011741	H-loop/switch region; other site
715451011742	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
715451011743	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
715451011744	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451011745	Walker A/P-loop; other site
715451011746	ATP binding site [chemical binding]; other site
715451011747	Q-loop/lid; other site
715451011748	ABC transporter signature motif; other site
715451011749	Walker B; other site
715451011750	D-loop; other site
715451011751	H-loop/switch region; other site
715451011752	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
715451011753	cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203
715451011754	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
715451011755	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
715451011756	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
715451011757	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
715451011758	PAS fold; Region: PAS_4; pfam08448
715451011759	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451011760	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
715451011761	Walker A motif; other site
715451011762	ATP binding site [chemical binding]; other site
715451011763	Walker B motif; other site
715451011764	arginine finger; other site
715451011765	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
715451011766	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
715451011767	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451011768	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
715451011769	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
715451011770	elongation factor P; Provisional; Region: PRK04542
715451011771	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
715451011772	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
715451011773	RNA binding site [nucleotide binding]; other site
715451011774	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
715451011775	RNA binding site [nucleotide binding]; other site
715451011776	Protein of unknown function (DUF419); Region: DUF419; cl15265
715451011777	AAA domain; Region: AAA_33; pfam13671
715451011778	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
715451011779	active site
715451011780	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
715451011781	Family description; Region: VCBS; pfam13517
715451011782	Family description; Region: VCBS; pfam13517
715451011783	Family description; Region: VCBS; pfam13517
715451011784	Family description; Region: VCBS; pfam13517
715451011785	Family description; Region: VCBS; pfam13517
715451011786	Family description; Region: VCBS; pfam13517
715451011787	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
715451011788	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
715451011789	SnoaL-like domain; Region: SnoaL_3; pfam13474
715451011790	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236
715451011791	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
715451011792	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
715451011793	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
715451011794	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
715451011795	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
715451011796	FAD binding pocket [chemical binding]; other site
715451011797	FAD binding motif [chemical binding]; other site
715451011798	phosphate binding motif [ion binding]; other site
715451011799	NAD binding pocket [chemical binding]; other site
715451011800	CsbD-like; Region: CsbD; cl17424
715451011801	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
715451011802	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
715451011803	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451011804	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
715451011805	DNA binding residues [nucleotide binding]
715451011806	Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561
715451011807	active site
715451011808	catalytic triad [active]
715451011809	hypothetical protein; Provisional; Region: PRK09256
715451011810	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
715451011811	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
715451011812	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
715451011813	S-formylglutathione hydrolase; Region: PLN02442
715451011814	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_27; cd04640
715451011815	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
715451011816	hypothetical protein; Provisional; Region: PRK03757
715451011817	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
715451011818	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
715451011819	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451011820	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451011821	N-terminal plug; other site
715451011822	ligand-binding site [chemical binding]; other site
715451011823	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
715451011824	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
715451011825	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451011826	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451011827	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
715451011828	dimerization interface [polypeptide binding]; other site
715451011829	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
715451011830	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
715451011831	Prostaglandin dehydrogenases; Region: PGDH; cd05288
715451011832	NAD(P) binding site [chemical binding]; other site
715451011833	substrate binding site [chemical binding]; other site
715451011834	dimer interface [polypeptide binding]; other site
715451011835	Herpesvirus Latent membrane protein 2; Region: Herpes_LAMP2; pfam06126
715451011836	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451011837	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451011838	metal binding site [ion binding]; metal-binding site
715451011839	active site
715451011840	I-site; other site
715451011841	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451011842	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
715451011843	dimerization interface [polypeptide binding]; other site
715451011844	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451011845	dimer interface [polypeptide binding]; other site
715451011846	phosphorylation site [posttranslational modification]
715451011847	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451011848	ATP binding site [chemical binding]; other site
715451011849	Mg2+ binding site [ion binding]; other site
715451011850	G-X-G motif; other site
715451011851	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451011852	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451011853	active site
715451011854	phosphorylation site [posttranslational modification]
715451011855	intermolecular recognition site; other site
715451011856	dimerization interface [polypeptide binding]; other site
715451011857	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
715451011858	Cupin superfamily (DUF985); Region: Cupin_5; cl01418
715451011859	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
715451011860	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
715451011861	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
715451011862	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
715451011863	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
715451011864	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
715451011865	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
715451011866	FtsX-like permease family; Region: FtsX; pfam02687
715451011867	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
715451011868	Walker A/P-loop; other site
715451011869	ATP binding site [chemical binding]; other site
715451011870	ABC transporter; Region: ABC_tran; pfam00005
715451011871	Q-loop/lid; other site
715451011872	ABC transporter signature motif; other site
715451011873	Walker B; other site
715451011874	D-loop; other site
715451011875	H-loop/switch region; other site
715451011876	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
715451011877	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
715451011878	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
715451011879	MerC mercury resistance protein; Region: MerC; cl03934
715451011880	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
715451011881	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
715451011882	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
715451011883	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451011884	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
715451011885	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
715451011886	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
715451011887	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
715451011888	S-adenosylmethionine binding site [chemical binding]; other site
715451011889	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
715451011890	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
715451011891	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
715451011892	glutaminase active site [active]
715451011893	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
715451011894	dimer interface [polypeptide binding]; other site
715451011895	active site
715451011896	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
715451011897	dimer interface [polypeptide binding]; other site
715451011898	active site
715451011899	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
715451011900	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
715451011901	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
715451011902	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
715451011903	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
715451011904	Substrate binding site; other site
715451011905	Mg++ binding site; other site
715451011906	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
715451011907	active site
715451011908	substrate binding site [chemical binding]; other site
715451011909	CoA binding site [chemical binding]; other site
715451011910	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451011911	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451011912	metal binding site [ion binding]; metal-binding site
715451011913	active site
715451011914	I-site; other site
715451011915	EamA-like transporter family; Region: EamA; pfam00892
715451011916	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
715451011917	EamA-like transporter family; Region: EamA; pfam00892
715451011918	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
715451011919	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
715451011920	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
715451011921	DNA binding site [nucleotide binding]
715451011922	active site
715451011923	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
715451011924	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
715451011925	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
715451011926	AlkA N-terminal domain; Region: AlkA_N; pfam06029
715451011927	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
715451011928	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
715451011929	minor groove reading motif; other site
715451011930	helix-hairpin-helix signature motif; other site
715451011931	substrate binding pocket [chemical binding]; other site
715451011932	active site
715451011933	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
715451011934	Beta-lactamase; Region: Beta-lactamase; pfam00144
715451011935	arginine decarboxylase; Provisional; Region: PRK05354
715451011936	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
715451011937	dimer interface [polypeptide binding]; other site
715451011938	active site
715451011939	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
715451011940	catalytic residues [active]
715451011941	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
715451011942	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
715451011943	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
715451011944	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
715451011945	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
715451011946	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
715451011947	ligand binding site [chemical binding]; other site
715451011948	homodimer interface [polypeptide binding]; other site
715451011949	NAD(P) binding site [chemical binding]; other site
715451011950	trimer interface B [polypeptide binding]; other site
715451011951	trimer interface A [polypeptide binding]; other site
715451011952	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
715451011953	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
715451011954	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
715451011955	UreF; Region: UreF; pfam01730
715451011956	urease accessory protein UreE; Provisional; Region: PRK14113
715451011957	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
715451011958	dimer interface [polypeptide binding]; other site
715451011959	catalytic residues [active]
715451011960	urease subunit alpha; Reviewed; Region: ureC; PRK13207
715451011961	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
715451011962	subunit interactions [polypeptide binding]; other site
715451011963	active site
715451011964	flap region; other site
715451011965	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
715451011966	gamma-beta subunit interface [polypeptide binding]; other site
715451011967	alpha-beta subunit interface [polypeptide binding]; other site
715451011968	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
715451011969	alpha-gamma subunit interface [polypeptide binding]; other site
715451011970	beta-gamma subunit interface [polypeptide binding]; other site
715451011971	UreD urease accessory protein; Region: UreD; pfam01774
715451011972	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
715451011973	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
715451011974	Walker A/P-loop; other site
715451011975	ATP binding site [chemical binding]; other site
715451011976	Q-loop/lid; other site
715451011977	ABC transporter signature motif; other site
715451011978	Walker B; other site
715451011979	D-loop; other site
715451011980	H-loop/switch region; other site
715451011981	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
715451011982	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
715451011983	Walker A/P-loop; other site
715451011984	ATP binding site [chemical binding]; other site
715451011985	Q-loop/lid; other site
715451011986	ABC transporter signature motif; other site
715451011987	Walker B; other site
715451011988	D-loop; other site
715451011989	H-loop/switch region; other site
715451011990	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
715451011991	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
715451011992	TM-ABC transporter signature motif; other site
715451011993	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
715451011994	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
715451011995	TM-ABC transporter signature motif; other site
715451011996	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
715451011997	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
715451011998	putative ligand binding site [chemical binding]; other site
715451011999	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
715451012000	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
715451012001	Na binding site [ion binding]; other site
715451012002	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451012003	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451012004	dimer interface [polypeptide binding]; other site
715451012005	phosphorylation site [posttranslational modification]
715451012006	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451012007	ATP binding site [chemical binding]; other site
715451012008	Mg2+ binding site [ion binding]; other site
715451012009	G-X-G motif; other site
715451012010	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
715451012011	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451012012	active site
715451012013	phosphorylation site [posttranslational modification]
715451012014	intermolecular recognition site; other site
715451012015	dimerization interface [polypeptide binding]; other site
715451012016	Response regulator receiver domain; Region: Response_reg; pfam00072
715451012017	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451012018	active site
715451012019	phosphorylation site [posttranslational modification]
715451012020	intermolecular recognition site; other site
715451012021	dimerization interface [polypeptide binding]; other site
715451012022	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
715451012023	DNA binding residues [nucleotide binding]
715451012024	dimerization interface [polypeptide binding]; other site
715451012025	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
715451012026	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
715451012027	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
715451012028	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
715451012029	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
715451012030	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
715451012031	metal binding site [ion binding]; metal-binding site
715451012032	active site
715451012033	I-site; other site
715451012034	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
715451012035	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
715451012036	binding surface
715451012037	Tetratricopeptide repeat; Region: TPR_16; pfam13432
715451012038	TPR motif; other site
715451012039	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
715451012040	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
715451012041	DNA binding site [nucleotide binding]
715451012042	Int/Topo IB signature motif; other site
715451012043	active site
715451012044	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
715451012045	active site
715451012046	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
715451012047	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
715451012048	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
715451012049	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
715451012050	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
715451012051	hypothetical protein; Reviewed; Region: PRK00024
715451012052	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
715451012053	MPN+ (JAMM) motif; other site
715451012054	Zinc-binding site [ion binding]; other site
715451012055	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
715451012056	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
715451012057	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
715451012058	TraU protein; Region: TraU; cl06067
715451012059	Protein of unknown function (DUF1525); Region: DUF1525; pfam07511
715451012060	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
715451012061	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
715451012062	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
715451012063	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
715451012064	Tumour protein D52 family; Region: TPD52; pfam04201
715451012065	Protein of unknown function (DUF3438); Region: DUF3438; cl13372
715451012066	Protein of unknown function (DUF2895); Region: DUF2895; cl12968
715451012067	Protein of unknown function (DUF3487); Region: DUF3487; cl13432
715451012068	integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745
715451012069	Protein of unknown function (DUF3262); Region: DUF3262; pfam11660
715451012070	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
715451012071	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
715451012072	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
715451012073	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
715451012074	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
715451012075	active site
715451012076	Patatin-like phospholipase; Region: Patatin; pfam01734
715451012077	nucleophile elbow; other site
715451012078	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
715451012079	Ion channel; Region: Ion_trans_2; pfam07885
715451012080	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
715451012081	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
715451012082	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
715451012083	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451012084	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
715451012085	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
715451012086	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
715451012087	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
715451012088	Putative serine esterase (DUF676); Region: DUF676; pfam05057
715451012089	Domain of unknown function (DUF4400); Region: DUF4400; cl14023
715451012090	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
715451012091	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
715451012092	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
715451012093	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
715451012094	N-acetyl-D-glucosamine binding site [chemical binding]; other site
715451012095	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
715451012096	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
715451012097	FimV N-terminal domain; Region: FimV_core; TIGR03505
715451012098	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
715451012099	Integrase; Region: Integrase_1; pfam12835
715451012100	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
715451012101	ParB-like nuclease domain; Region: ParBc; pfam02195
715451012102	Helix-turn-helix domain; Region: HTH_37; pfam13744
715451012103	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
715451012104	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
715451012105	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
715451012106	active site
715451012107	Int/Topo IB signature motif; other site
715451012108	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
715451012109	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
715451012110	ring oligomerisation interface [polypeptide binding]; other site
715451012111	ATP/Mg binding site [chemical binding]; other site
715451012112	stacking interactions; other site
715451012113	hinge regions; other site
715451012114	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
715451012115	oligomerisation interface [polypeptide binding]; other site
715451012116	mobile loop; other site
715451012117	roof hairpin; other site
715451012118	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
715451012119	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
715451012120	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
715451012121	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
715451012122	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
715451012123	DsbD alpha interface [polypeptide binding]; other site
715451012124	catalytic residues [active]
715451012125	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
715451012126	Peptidase family M23; Region: Peptidase_M23; pfam01551
715451012127	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
715451012128	Dehydroquinase class II; Region: DHquinase_II; pfam01220
715451012129	active site
715451012130	trimer interface [polypeptide binding]; other site
715451012131	dimer interface [polypeptide binding]; other site
715451012132	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
715451012133	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
715451012134	carboxyltransferase (CT) interaction site; other site
715451012135	biotinylation site [posttranslational modification]; other site
715451012136	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
715451012137	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
715451012138	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
715451012139	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
715451012140	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
715451012141	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
715451012142	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
715451012143	active site
715451012144	catalytic site [active]
715451012145	substrate binding site [chemical binding]; other site
715451012146	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
715451012147	High potential iron-sulfur protein; Region: HIPIP; pfam01355
715451012148	amidase; Provisional; Region: PRK08137
715451012149	Amidase; Region: Amidase; cl11426
715451012150	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
715451012151	active site
715451012152	catalytic residues [active]
715451012153	DNA binding site [nucleotide binding]
715451012154	Int/Topo IB signature motif; other site
715451012155	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451012156	ABC transporter signature motif; other site
715451012157	Walker B; other site
715451012158	D-loop; other site
715451012159	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
715451012160	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
715451012161	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
715451012162	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
715451012163	active site
715451012164	catalytic tetrad [active]
715451012165	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
715451012166	classical (c) SDRs; Region: SDR_c; cd05233
715451012167	NAD(P) binding site [chemical binding]; other site
715451012168	active site
715451012169	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
715451012170	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
715451012171	putative active site [active]
715451012172	metal binding site [ion binding]; metal-binding site
715451012173	Transcriptional regulator [Transcription]; Region: LysR; COG0583
715451012174	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451012175	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
715451012176	putative effector binding pocket; other site
715451012177	dimerization interface [polypeptide binding]; other site
715451012178	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
715451012179	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451012180	Walker A motif; other site
715451012181	ATP binding site [chemical binding]; other site
715451012182	Walker B motif; other site
715451012183	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
715451012184	Integrase core domain; Region: rve; pfam00665
715451012185	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
715451012186	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
715451012187	substrate binding pocket [chemical binding]; other site
715451012188	membrane-bound complex binding site; other site
715451012189	hinge residues; other site
715451012190	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
715451012191	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451012192	S-adenosylmethionine binding site [chemical binding]; other site
715451012193	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
715451012194	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
715451012195	FMN binding site [chemical binding]; other site
715451012196	active site
715451012197	catalytic residues [active]
715451012198	substrate binding site [chemical binding]; other site
715451012199	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
715451012200	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
715451012201	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
715451012202	purine monophosphate binding site [chemical binding]; other site
715451012203	dimer interface [polypeptide binding]; other site
715451012204	putative catalytic residues [active]
715451012205	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
715451012206	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
715451012207	Predicted methyltransferase [General function prediction only]; Region: COG4798
715451012208	Methyltransferase domain; Region: Methyltransf_23; pfam13489
715451012209	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
715451012210	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
715451012211	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
715451012212	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
715451012213	Domain of unknown function (DUF1083); Region: DUF1083; pfam06452
715451012214	Ion transport protein; Region: Ion_trans; pfam00520
715451012215	Ion channel; Region: Ion_trans_2; pfam07885
715451012216	phosphoribulokinase; Provisional; Region: PRK15453
715451012217	HTH-like domain; Region: HTH_21; pfam13276
715451012218	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
715451012219	Transposase; Region: HTH_Tnp_1; pfam01527
715451012220	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
715451012221	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
715451012222	HlyD family secretion protein; Region: HlyD_3; pfam13437
715451012223	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
715451012224	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451012225	ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748
715451012226	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
715451012227	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451012228	dimer interface [polypeptide binding]; other site
715451012229	phosphorylation site [posttranslational modification]
715451012230	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
715451012231	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451012232	active site
715451012233	phosphorylation site [posttranslational modification]
715451012234	intermolecular recognition site; other site
715451012235	dimerization interface [polypeptide binding]; other site
715451012236	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451012237	DNA binding site [nucleotide binding]
715451012238	pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099
715451012239	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
715451012240	dimer interface [polypeptide binding]; other site
715451012241	active site
715451012242	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
715451012243	catalytic residues [active]
715451012244	substrate binding site [chemical binding]; other site
715451012245	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
715451012246	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
715451012247	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
715451012248	acyl-activating enzyme (AAE) consensus motif; other site
715451012249	acyl-activating enzyme (AAE) consensus motif; other site
715451012250	AMP binding site [chemical binding]; other site
715451012251	active site
715451012252	CoA binding site [chemical binding]; other site
715451012253	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
715451012254	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
715451012255	Transposase [DNA replication, recombination, and repair]; Region: COG5433
715451012256	Transposase [DNA replication, recombination, and repair]; Region: COG5433
715451012257	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
715451012258	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
715451012259	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451012260	Walker A/P-loop; other site
715451012261	ATP binding site [chemical binding]; other site
715451012262	Q-loop/lid; other site
715451012263	ABC transporter signature motif; other site
715451012264	Walker B; other site
715451012265	D-loop; other site
715451012266	H-loop/switch region; other site
715451012267	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
715451012268	putative acyl-acceptor binding pocket; other site
715451012269	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
715451012270	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
715451012271	Transposase [DNA replication, recombination, and repair]; Region: COG5433
715451012272	Transposase [DNA replication, recombination, and repair]; Region: COG5433
715451012273	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
715451012274	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
715451012275	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
715451012276	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
715451012277	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
715451012278	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
715451012279	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
715451012280	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
715451012281	Protein of unknown function (DUF2855); Region: DUF2855; pfam11017
715451012282	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
715451012283	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
715451012284	osmolarity response regulator; Provisional; Region: ompR; PRK09468
715451012285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
715451012286	active site
715451012287	phosphorylation site [posttranslational modification]
715451012288	intermolecular recognition site; other site
715451012289	dimerization interface [polypeptide binding]; other site
715451012290	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
715451012291	DNA binding site [nucleotide binding]
715451012292	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
715451012293	HAMP domain; Region: HAMP; pfam00672
715451012294	dimerization interface [polypeptide binding]; other site
715451012295	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
715451012296	dimer interface [polypeptide binding]; other site
715451012297	phosphorylation site [posttranslational modification]
715451012298	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
715451012299	ATP binding site [chemical binding]; other site
715451012300	Mg2+ binding site [ion binding]; other site
715451012301	G-X-G motif; other site
715451012302	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451012303	putative substrate translocation pore; other site
715451012304	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
715451012305	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
715451012306	active site
715451012307	substrate-binding site [chemical binding]; other site
715451012308	metal-binding site [ion binding]
715451012309	ATP binding site [chemical binding]; other site
715451012310	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
715451012311	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
715451012312	dimerization interface [polypeptide binding]; other site
715451012313	domain crossover interface; other site
715451012314	redox-dependent activation switch; other site
715451012315	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
715451012316	RNA binding surface [nucleotide binding]; other site
715451012317	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
715451012318	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
715451012319	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
715451012320	type II secretion system protein D; Region: type_II_gspD; TIGR02517
715451012321	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
715451012322	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
715451012323	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
715451012324	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
715451012325	type II secretion system protein E; Region: type_II_gspE; TIGR02533
715451012326	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
715451012327	Walker A motif; other site
715451012328	ATP binding site [chemical binding]; other site
715451012329	Walker B motif; other site
715451012330	type II secretion system protein F; Region: GspF; TIGR02120
715451012331	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
715451012332	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
715451012333	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
715451012334	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
715451012335	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
715451012336	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
715451012337	type II secretion system protein I; Region: gspI; TIGR01707
715451012338	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
715451012339	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
715451012340	type II secretion system protein J; Region: gspJ; TIGR01711
715451012341	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
715451012342	PilX N-terminal; Region: PilX_N; pfam14341
715451012343	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
715451012344	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
715451012345	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
715451012346	GspL periplasmic domain; Region: GspL_C; pfam12693
715451012347	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
715451012348	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
715451012349	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
715451012350	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
715451012351	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
715451012352	NAD(P) binding site [chemical binding]; other site
715451012353	catalytic residues [active]
715451012354	Protein of unknown function DUF84; Region: NTPase_I-T; cl00866
715451012355	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
715451012356	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
715451012357	motif II; other site
715451012358	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
715451012359	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
715451012360	dimer interface [polypeptide binding]; other site
715451012361	ADP-ribose binding site [chemical binding]; other site
715451012362	active site
715451012363	nudix motif; other site
715451012364	metal binding site [ion binding]; metal-binding site
715451012365	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
715451012366	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
715451012367	active site
715451012368	YceI-like domain; Region: YceI; pfam04264
715451012369	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
715451012370	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
715451012371	Ligand binding site; other site
715451012372	DXD motif; other site
715451012373	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
715451012374	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
715451012375	sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273
715451012376	Uncharacterized protein family (UPF0270); Region: UPF0270; pfam06794
715451012377	putative hydrolase; Provisional; Region: PRK10985
715451012378	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
715451012379	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
715451012380	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451012381	Walker A/P-loop; other site
715451012382	ATP binding site [chemical binding]; other site
715451012383	Q-loop/lid; other site
715451012384	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
715451012385	ABC transporter; Region: ABC_tran_2; pfam12848
715451012386	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
715451012387	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
715451012388	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
715451012389	SlyX; Region: SlyX; pfam04102
715451012390	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
715451012391	FOG: WD40 repeat [General function prediction only]; Region: COG2319
715451012392	structural tetrad; other site
715451012393	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
715451012394	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
715451012395	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
715451012396	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
715451012397	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
715451012398	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
715451012399	cofactor binding site; other site
715451012400	DNA binding site [nucleotide binding]
715451012401	substrate interaction site [chemical binding]; other site
715451012402	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
715451012403	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
715451012404	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451012405	Walker A motif; other site
715451012406	ATP binding site [chemical binding]; other site
715451012407	Walker B motif; other site
715451012408	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
715451012409	Integrase core domain; Region: rve; pfam00665
715451012410	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
715451012411	Uncharacterized conserved protein [Function unknown]; Region: COG4938
715451012412	Walker A/P-loop; other site
715451012413	ATP binding site [chemical binding]; other site
715451012414	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
715451012415	non-specific DNA binding site [nucleotide binding]; other site
715451012416	salt bridge; other site
715451012417	sequence-specific DNA binding site [nucleotide binding]; other site
715451012418	Protein of unknown function (DUF1804); Region: DUF1804; pfam08822
715451012419	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
715451012420	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
715451012421	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
715451012422	Putative phage integrase; Region: Phage_Integr_2; pfam13009
715451012423	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
715451012424	DNA binding site [nucleotide binding]
715451012425	active site
715451012426	Int/Topo IB signature motif; other site
715451012427	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
715451012428	DNA binding site [nucleotide binding]
715451012429	Int/Topo IB signature motif; other site
715451012430	active site
715451012431	catalytic residues [active]
715451012432	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
715451012433	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
715451012434	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
715451012435	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
715451012436	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
715451012437	RNA binding site [nucleotide binding]; other site
715451012438	SprA-related family; Region: SprA-related; pfam12118
715451012439	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
715451012440	PGAP1-like protein; Region: PGAP1; pfam07819
715451012441	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
715451012442	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238
715451012443	putative active site [active]
715451012444	Zn binding site [ion binding]; other site
715451012445	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
715451012446	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
715451012447	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
715451012448	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
715451012449	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
715451012450	aspartate racemase; Region: asp_race; TIGR00035
715451012451	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
715451012452	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
715451012453	Methyltransferase domain; Region: Methyltransf_23; pfam13489
715451012454	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451012455	S-adenosylmethionine binding site [chemical binding]; other site
715451012456	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
715451012457	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
715451012458	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
715451012459	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
715451012460	Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973
715451012461	putative active site [active]
715451012462	putative metal binding site [ion binding]; other site
715451012463	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
715451012464	Coenzyme A binding pocket [chemical binding]; other site
715451012465	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
715451012466	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
715451012467	Cu(I) binding site [ion binding]; other site
715451012468	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
715451012469	UbiA prenyltransferase family; Region: UbiA; pfam01040
715451012470	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
715451012471	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
715451012472	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
715451012473	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
715451012474	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
715451012475	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
715451012476	Subunit III/VIIa interface [polypeptide binding]; other site
715451012477	Phospholipid binding site [chemical binding]; other site
715451012478	Subunit I/III interface [polypeptide binding]; other site
715451012479	Subunit III/VIb interface [polypeptide binding]; other site
715451012480	Subunit III/VIa interface; other site
715451012481	Subunit III/Vb interface [polypeptide binding]; other site
715451012482	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
715451012483	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
715451012484	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
715451012485	Subunit I/III interface [polypeptide binding]; other site
715451012486	D-pathway; other site
715451012487	Subunit I/VIIc interface [polypeptide binding]; other site
715451012488	Subunit I/IV interface [polypeptide binding]; other site
715451012489	Subunit I/II interface [polypeptide binding]; other site
715451012490	Low-spin heme (heme a) binding site [chemical binding]; other site
715451012491	Subunit I/VIIa interface [polypeptide binding]; other site
715451012492	Subunit I/VIa interface [polypeptide binding]; other site
715451012493	Dimer interface; other site
715451012494	Putative water exit pathway; other site
715451012495	Binuclear center (heme a3/CuB) [ion binding]; other site
715451012496	K-pathway; other site
715451012497	Subunit I/Vb interface [polypeptide binding]; other site
715451012498	Putative proton exit pathway; other site
715451012499	Subunit I/VIb interface; other site
715451012500	Subunit I/VIc interface [polypeptide binding]; other site
715451012501	Electron transfer pathway; other site
715451012502	Subunit I/VIIIb interface [polypeptide binding]; other site
715451012503	Subunit I/VIIb interface [polypeptide binding]; other site
715451012504	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154
715451012505	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
715451012506	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
715451012507	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
715451012508	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
715451012509	LexA repressor; Validated; Region: PRK00215
715451012510	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
715451012511	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
715451012512	Catalytic site [active]
715451012513	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
715451012514	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
715451012515	N-terminal plug; other site
715451012516	ligand-binding site [chemical binding]; other site
715451012517	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
715451012518	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
715451012519	Coenzyme A binding pocket [chemical binding]; other site
715451012520	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
715451012521	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
715451012522	putative acyl-acceptor binding pocket; other site
715451012523	threonine dehydratase; Reviewed; Region: PRK09224
715451012524	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
715451012525	tetramer interface [polypeptide binding]; other site
715451012526	pyridoxal 5'-phosphate binding site [chemical binding]; other site
715451012527	catalytic residue [active]
715451012528	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
715451012529	putative Ile/Val binding site [chemical binding]; other site
715451012530	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
715451012531	putative Ile/Val binding site [chemical binding]; other site
715451012532	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
715451012533	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
715451012534	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
715451012535	homodimer interface [polypeptide binding]; other site
715451012536	substrate-cofactor binding pocket; other site
715451012537	catalytic residue [active]
715451012538	UPF0126 domain; Region: UPF0126; pfam03458
715451012539	Predicted membrane protein [Function unknown]; Region: COG2860
715451012540	UPF0126 domain; Region: UPF0126; pfam03458
715451012541	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
715451012542	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
715451012543	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
715451012544	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
715451012545	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
715451012546	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
715451012547	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
715451012548	putative dimerization interface [polypeptide binding]; other site
715451012549	ketol-acid reductoisomerase; Validated; Region: PRK05225
715451012550	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
715451012551	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
715451012552	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
715451012553	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
715451012554	putative substrate translocation pore; other site
715451012555	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
715451012556	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
715451012557	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
715451012558	Surface antigen; Region: Bac_surface_Ag; pfam01103
715451012559	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
715451012560	Family of unknown function (DUF490); Region: DUF490; pfam04357
715451012561	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
715451012562	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
715451012563	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
715451012564	DNA binding residues [nucleotide binding]
715451012565	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
715451012566	EamA-like transporter family; Region: EamA; pfam00892
715451012567	glycerate dehydrogenase; Provisional; Region: PRK06487
715451012568	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
715451012569	putative ligand binding site [chemical binding]; other site
715451012570	putative NAD binding site [chemical binding]; other site
715451012571	catalytic site [active]
715451012572	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
715451012573	active site
715451012574	gamma-glutamyl kinase; Provisional; Region: PRK05429
715451012575	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
715451012576	nucleotide binding site [chemical binding]; other site
715451012577	homotetrameric interface [polypeptide binding]; other site
715451012578	putative phosphate binding site [ion binding]; other site
715451012579	putative allosteric binding site; other site
715451012580	PUA domain; Region: PUA; pfam01472
715451012581	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
715451012582	Zn binding site [ion binding]; other site
715451012583	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
715451012584	ABC1 family; Region: ABC1; cl17513
715451012585	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
715451012586	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
715451012587	Protein of unknown function (DUF3014); Region: DUF3014; pfam11219
715451012588	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
715451012589	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
715451012590	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
715451012591	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
715451012592	active site
715451012593	Predicted membrane protein [Function unknown]; Region: COG1238
715451012594	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
715451012595	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
715451012596	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
715451012597	CPxP  motif; other site
715451012598	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
715451012599	active site
715451012600	ribonuclease PH; Reviewed; Region: rph; PRK00173
715451012601	Ribonuclease PH; Region: RNase_PH_bact; cd11362
715451012602	hexamer interface [polypeptide binding]; other site
715451012603	active site
715451012604	hypothetical protein; Provisional; Region: PRK11820
715451012605	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
715451012606	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
715451012607	integrase; Provisional; Region: PRK09692
715451012608	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
715451012609	active site
715451012610	Int/Topo IB signature motif; other site
715451012611	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
715451012612	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
715451012613	non-specific DNA binding site [nucleotide binding]; other site
715451012614	salt bridge; other site
715451012615	sequence-specific DNA binding site [nucleotide binding]; other site
715451012616	potential frameshift: common BLAST hit: gi|196158851|ref|YP_002128340.1| DNA helicase of superfamily II
715451012617	Superfamily II helicase [General function prediction only]; Region: COG1204
715451012618	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
715451012619	ATP binding site [chemical binding]; other site
715451012620	putative Mg++ binding site [ion binding]; other site
715451012621	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
715451012622	nucleotide binding region [chemical binding]; other site
715451012623	ATP-binding site [chemical binding]; other site
715451012624	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
715451012625	HsdM N-terminal domain; Region: HsdM_N; pfam12161
715451012626	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
715451012627	Methyltransferase domain; Region: Methyltransf_26; pfam13659
715451012628	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
715451012629	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
715451012630	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
715451012631	ATP binding site [chemical binding]; other site
715451012632	putative Mg++ binding site [ion binding]; other site
715451012633	DNA binding domain, excisionase family; Region: excise; TIGR01764
715451012634	Domain of unknown function (DUF927); Region: DUF927; pfam06048
715451012635	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
715451012636	HipA N-terminal domain; Region: Couple_hipA; cl11853
715451012637	HipA-like N-terminal domain; Region: HipA_N; pfam07805
715451012638	HipA-like C-terminal domain; Region: HipA_C; pfam07804
715451012639	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
715451012640	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
715451012641	Walker A motif; other site
715451012642	ATP binding site [chemical binding]; other site
715451012643	Walker B motif; other site
715451012644	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
715451012645	HipA N-terminal domain; Region: Couple_hipA; pfam13657
715451012646	HipA-like N-terminal domain; Region: HipA_N; pfam07805
715451012647	HipA-like C-terminal domain; Region: HipA_C; pfam07804
715451012648	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
715451012649	non-specific DNA binding site [nucleotide binding]; other site
715451012650	salt bridge; other site
715451012651	sequence-specific DNA binding site [nucleotide binding]; other site
715451012652	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
715451012653	putative hydrophobic ligand binding site [chemical binding]; other site
715451012654	gate; other site
715451012655	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
715451012656	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
715451012657	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
715451012658	potential frameshift: common BLAST hit: gi|109899583|ref|YP_662838.1| TonB-dependent receptor
715451012659	beta-galactosidase; Region: BGL; TIGR03356
715451012660	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
715451012661	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
715451012662	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
715451012663	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
715451012664	Transcriptional regulators [Transcription]; Region: PurR; COG1609
715451012665	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
715451012666	DNA binding site [nucleotide binding]
715451012667	domain linker motif; other site
715451012668	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
715451012669	dimerization interface (closed form) [polypeptide binding]; other site
715451012670	ligand binding site [chemical binding]; other site
715451012671	SnoaL-like domain; Region: SnoaL_3; pfam13474
715451012672	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
715451012673	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
715451012674	ligand binding site [chemical binding]; other site
715451012675	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
715451012676	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
715451012677	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
715451012678	Zn2+ binding site [ion binding]; other site
715451012679	Mg2+ binding site [ion binding]; other site
715451012680	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
715451012681	DNA binding site [nucleotide binding]
715451012682	active site
715451012683	DTW domain; Region: DTW; cl01221
715451012684	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
715451012685	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
715451012686	putative C-terminal domain interface [polypeptide binding]; other site
715451012687	putative GSH binding site (G-site) [chemical binding]; other site
715451012688	putative dimer interface [polypeptide binding]; other site
715451012689	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
715451012690	N-terminal domain interface [polypeptide binding]; other site
715451012691	dimer interface [polypeptide binding]; other site
715451012692	substrate binding pocket (H-site) [chemical binding]; other site
715451012693	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
715451012694	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
715451012695	gamma subunit interface [polypeptide binding]; other site
715451012696	epsilon subunit interface [polypeptide binding]; other site
715451012697	LBP interface [polypeptide binding]; other site
715451012698	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
715451012699	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
715451012700	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
715451012701	alpha subunit interaction interface [polypeptide binding]; other site
715451012702	Walker A motif; other site
715451012703	ATP binding site [chemical binding]; other site
715451012704	Walker B motif; other site
715451012705	inhibitor binding site; inhibition site
715451012706	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
715451012707	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
715451012708	core domain interface [polypeptide binding]; other site
715451012709	delta subunit interface [polypeptide binding]; other site
715451012710	epsilon subunit interface [polypeptide binding]; other site
715451012711	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
715451012712	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
715451012713	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
715451012714	beta subunit interaction interface [polypeptide binding]; other site
715451012715	Walker A motif; other site
715451012716	ATP binding site [chemical binding]; other site
715451012717	Walker B motif; other site
715451012718	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
715451012719	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
715451012720	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
715451012721	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
715451012722	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
715451012723	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
715451012724	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
715451012725	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
715451012726	ATP synthase I chain; Region: ATP_synt_I; cl09170
715451012727	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
715451012728	ParB-like nuclease domain; Region: ParBc; pfam02195
715451012729	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
715451012730	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
715451012731	P-loop; other site
715451012732	Magnesium ion binding site [ion binding]; other site
715451012733	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
715451012734	Magnesium ion binding site [ion binding]; other site
715451012735	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
715451012736	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
715451012737	S-adenosylmethionine binding site [chemical binding]; other site
715451012738	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
715451012739	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
715451012740	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
715451012741	hypothetical protein; Validated; Region: PRK08116
715451012742	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
715451012743	primosomal protein DnaI; Provisional; Region: PRK02854
715451012744	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
715451012745	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
715451012746	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
715451012747	trmE is a tRNA modification GTPase; Region: trmE; cd04164
715451012748	G1 box; other site
715451012749	GTP/Mg2+ binding site [chemical binding]; other site
715451012750	Switch I region; other site
715451012751	G2 box; other site
715451012752	Switch II region; other site
715451012753	G3 box; other site
715451012754	G4 box; other site
715451012755	G5 box; other site
715451012756	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
715451012757	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
715451012758	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
715451012759	membrane protein insertase; Provisional; Region: PRK01318
715451012760	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
715451012761	Haemolytic domain; Region: Haemolytic; pfam01809
715451012762	ribonuclease P; Reviewed; Region: rnpA; PRK01732