-- dump date 20140618_202537 -- class Genbank::misc_feature -- table misc_feature_note -- id note 572547000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 572547000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 572547000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572547000004 Walker A motif; other site 572547000005 ATP binding site [chemical binding]; other site 572547000006 Walker B motif; other site 572547000007 arginine finger; other site 572547000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 572547000009 DnaA box-binding interface [nucleotide binding]; other site 572547000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 572547000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 572547000012 putative DNA binding surface [nucleotide binding]; other site 572547000013 dimer interface [polypeptide binding]; other site 572547000014 beta-clamp/clamp loader binding surface; other site 572547000015 beta-clamp/translesion DNA polymerase binding surface; other site 572547000016 recombination protein F; Reviewed; Region: recF; PRK00064 572547000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572547000018 ATP binding site [chemical binding]; other site 572547000019 Walker A/P-loop; other site 572547000020 Q-loop/lid; other site 572547000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572547000022 ABC transporter signature motif; other site 572547000023 Walker B; other site 572547000024 D-loop; other site 572547000025 H-loop/switch region; other site 572547000026 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 572547000027 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 572547000028 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 572547000029 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 572547000030 Protein of unknown function (DUF721); Region: DUF721; pfam05258 572547000031 Uncharacterized conserved protein [Function unknown]; Region: COG1284 572547000032 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572547000033 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 572547000034 pantoate--beta-alanine ligase; Region: panC; TIGR00018 572547000035 Pantoate-beta-alanine ligase; Region: PanC; cd00560 572547000036 active site 572547000037 ATP-binding site [chemical binding]; other site 572547000038 pantoate-binding site; other site 572547000039 HXXH motif; other site 572547000040 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 572547000041 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 572547000042 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 572547000043 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 572547000044 dimer interface [polypeptide binding]; other site 572547000045 active site 572547000046 catalytic residue [active] 572547000047 dihydrodipicolinate reductase; Provisional; Region: PRK00048 572547000048 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 572547000049 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 572547000050 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 572547000051 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 572547000052 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 572547000053 putative trimer interface [polypeptide binding]; other site 572547000054 putative CoA binding site [chemical binding]; other site 572547000055 aspartate kinase; Reviewed; Region: PRK06635 572547000056 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 572547000057 putative nucleotide binding site [chemical binding]; other site 572547000058 putative catalytic residues [active] 572547000059 putative Mg ion binding site [ion binding]; other site 572547000060 putative aspartate binding site [chemical binding]; other site 572547000061 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 572547000062 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 572547000063 putative allosteric regulatory residue; other site 572547000064 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 572547000065 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 572547000066 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 572547000067 P loop nucleotide binding; other site 572547000068 switch II; other site 572547000069 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 572547000070 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 572547000071 P loop nucleotide binding; other site 572547000072 switch II; other site 572547000073 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 572547000074 ferric uptake regulator; Provisional; Region: fur; PRK09462 572547000075 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 572547000076 metal binding site 2 [ion binding]; metal-binding site 572547000077 putative DNA binding helix; other site 572547000078 metal binding site 1 [ion binding]; metal-binding site 572547000079 dimer interface [polypeptide binding]; other site 572547000080 structural Zn2+ binding site [ion binding]; other site 572547000081 Response regulator receiver domain; Region: Response_reg; pfam00072 572547000082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 572547000083 active site 572547000084 phosphorylation site [posttranslational modification] 572547000085 intermolecular recognition site; other site 572547000086 dimerization interface [polypeptide binding]; other site 572547000087 Creatinine amidohydrolase; Region: Creatininase; pfam02633 572547000088 isoaspartyl dipeptidase; Provisional; Region: PRK10657 572547000089 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572547000090 active site 572547000091 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 572547000092 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 572547000093 active site 572547000094 PHP-associated; Region: PHP_C; pfam13263 572547000095 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 572547000096 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 572547000097 NodB motif; other site 572547000098 putative active site [active] 572547000099 putative catalytic site [active] 572547000100 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 572547000101 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 572547000102 putative active site; other site 572547000103 catalytic residue [active] 572547000104 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 572547000105 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 572547000106 Predicted thioesterase [General function prediction only]; Region: COG5496 572547000107 MOSC domain; Region: MOSC; pfam03473 572547000108 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572547000109 ATP binding site [chemical binding]; other site 572547000110 putative Mg++ binding site [ion binding]; other site 572547000111 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572547000112 nucleotide binding region [chemical binding]; other site 572547000113 ATP-binding site [chemical binding]; other site 572547000114 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 572547000115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547000116 dimer interface [polypeptide binding]; other site 572547000117 conserved gate region; other site 572547000118 putative PBP binding loops; other site 572547000119 ABC-ATPase subunit interface; other site 572547000120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572547000121 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 572547000122 Walker A/P-loop; other site 572547000123 ATP binding site [chemical binding]; other site 572547000124 Q-loop/lid; other site 572547000125 ABC transporter signature motif; other site 572547000126 Walker B; other site 572547000127 D-loop; other site 572547000128 H-loop/switch region; other site 572547000129 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 572547000130 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 572547000131 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 572547000132 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 572547000133 active site 572547000134 dimerization interface [polypeptide binding]; other site 572547000135 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 572547000136 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 572547000137 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 572547000138 PhoU domain; Region: PhoU; pfam01895 572547000139 PhoU domain; Region: PhoU; pfam01895 572547000140 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572547000141 dimerization interface [polypeptide binding]; other site 572547000142 putative Zn2+ binding site [ion binding]; other site 572547000143 putative DNA binding site [nucleotide binding]; other site 572547000144 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 572547000145 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 572547000146 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 572547000147 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 572547000148 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 572547000149 Walker A/P-loop; other site 572547000150 ATP binding site [chemical binding]; other site 572547000151 Q-loop/lid; other site 572547000152 ABC transporter signature motif; other site 572547000153 Walker B; other site 572547000154 D-loop; other site 572547000155 H-loop/switch region; other site 572547000156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 572547000157 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 572547000158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547000159 dimer interface [polypeptide binding]; other site 572547000160 conserved gate region; other site 572547000161 putative PBP binding loops; other site 572547000162 ABC-ATPase subunit interface; other site 572547000163 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 572547000164 PBP superfamily domain; Region: PBP_like_2; cl17296 572547000165 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 572547000166 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 572547000167 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 572547000168 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 572547000169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547000170 dimer interface [polypeptide binding]; other site 572547000171 conserved gate region; other site 572547000172 putative PBP binding loops; other site 572547000173 ABC-ATPase subunit interface; other site 572547000174 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 572547000175 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 572547000176 Walker A/P-loop; other site 572547000177 ATP binding site [chemical binding]; other site 572547000178 Q-loop/lid; other site 572547000179 ABC transporter signature motif; other site 572547000180 Walker B; other site 572547000181 D-loop; other site 572547000182 H-loop/switch region; other site 572547000183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547000184 putative PBP binding loops; other site 572547000185 dimer interface [polypeptide binding]; other site 572547000186 ABC-ATPase subunit interface; other site 572547000187 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572547000188 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572547000189 substrate binding pocket [chemical binding]; other site 572547000190 membrane-bound complex binding site; other site 572547000191 hinge residues; other site 572547000192 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 572547000193 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 572547000194 CoenzymeA binding site [chemical binding]; other site 572547000195 subunit interaction site [polypeptide binding]; other site 572547000196 PHB binding site; other site 572547000197 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 572547000198 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 572547000199 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 572547000200 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 572547000201 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 572547000202 putative metal binding site [ion binding]; other site 572547000203 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 572547000204 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572547000205 ABC-ATPase subunit interface; other site 572547000206 dimer interface [polypeptide binding]; other site 572547000207 putative PBP binding regions; other site 572547000208 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 572547000209 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 572547000210 Walker A/P-loop; other site 572547000211 ATP binding site [chemical binding]; other site 572547000212 Q-loop/lid; other site 572547000213 ABC transporter signature motif; other site 572547000214 Walker B; other site 572547000215 D-loop; other site 572547000216 H-loop/switch region; other site 572547000217 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 572547000218 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 572547000219 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 572547000220 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572547000221 active site 572547000222 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 572547000223 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 572547000224 metal-binding site [ion binding] 572547000225 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572547000226 Predicted permease; Region: DUF318; cl17795 572547000227 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 572547000228 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572547000229 dimerization interface [polypeptide binding]; other site 572547000230 putative DNA binding site [nucleotide binding]; other site 572547000231 putative Zn2+ binding site [ion binding]; other site 572547000232 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 572547000233 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 572547000234 Walker A/P-loop; other site 572547000235 ATP binding site [chemical binding]; other site 572547000236 Q-loop/lid; other site 572547000237 ABC transporter signature motif; other site 572547000238 Walker B; other site 572547000239 D-loop; other site 572547000240 H-loop/switch region; other site 572547000241 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 572547000242 cobalt transport protein CbiM; Validated; Region: PRK06265 572547000243 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 572547000244 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 572547000245 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 572547000246 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572547000247 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572547000248 substrate binding pocket [chemical binding]; other site 572547000249 membrane-bound complex binding site; other site 572547000250 hinge residues; other site 572547000251 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 572547000252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547000253 dimer interface [polypeptide binding]; other site 572547000254 conserved gate region; other site 572547000255 putative PBP binding loops; other site 572547000256 ABC-ATPase subunit interface; other site 572547000257 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 572547000258 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 572547000259 Walker A/P-loop; other site 572547000260 ATP binding site [chemical binding]; other site 572547000261 Q-loop/lid; other site 572547000262 ABC transporter signature motif; other site 572547000263 Walker B; other site 572547000264 D-loop; other site 572547000265 H-loop/switch region; other site 572547000266 threonine synthase; Validated; Region: PRK06260 572547000267 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 572547000268 homodimer interface [polypeptide binding]; other site 572547000269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547000270 catalytic residue [active] 572547000271 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 572547000272 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 572547000273 homodimer interface [polypeptide binding]; other site 572547000274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547000275 catalytic residue [active] 572547000276 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 572547000277 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572547000278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547000279 homodimer interface [polypeptide binding]; other site 572547000280 catalytic residue [active] 572547000281 4Fe-4S binding domain; Region: Fer4_5; pfam12801 572547000282 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 572547000283 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 572547000284 nucleoside/Zn binding site; other site 572547000285 dimer interface [polypeptide binding]; other site 572547000286 catalytic motif [active] 572547000287 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 572547000288 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 572547000289 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 572547000290 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 572547000291 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 572547000292 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 572547000293 putative deacylase active site [active] 572547000294 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 572547000295 anticodon binding site; other site 572547000296 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 572547000297 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 572547000298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 572547000299 Protein of unknown function (DUF997); Region: DUF997; pfam06196 572547000300 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 572547000301 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 572547000302 Na binding site [ion binding]; other site 572547000303 Transcriptional regulator [Transcription]; Region: IclR; COG1414 572547000304 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572547000305 putative DNA binding site [nucleotide binding]; other site 572547000306 putative Zn2+ binding site [ion binding]; other site 572547000307 Bacterial transcriptional regulator; Region: IclR; pfam01614 572547000308 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 572547000309 oligomerization interface [polypeptide binding]; other site 572547000310 active site 572547000311 metal binding site [ion binding]; metal-binding site 572547000312 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 572547000313 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 572547000314 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 572547000315 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 572547000316 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 572547000317 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 572547000318 DctM-like transporters; Region: DctM; pfam06808 572547000319 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 572547000320 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 572547000321 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 572547000322 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 572547000323 putative FMN binding site [chemical binding]; other site 572547000324 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 572547000325 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 572547000326 phosphate binding site [ion binding]; other site 572547000327 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 572547000328 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 572547000329 dimer interface [polypeptide binding]; other site 572547000330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547000331 catalytic residue [active] 572547000332 serine O-acetyltransferase; Region: cysE; TIGR01172 572547000333 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 572547000334 trimer interface [polypeptide binding]; other site 572547000335 active site 572547000336 substrate binding site [chemical binding]; other site 572547000337 CoA binding site [chemical binding]; other site 572547000338 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 572547000339 tartrate dehydrogenase; Region: TTC; TIGR02089 572547000340 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 572547000341 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 572547000342 substrate binding site [chemical binding]; other site 572547000343 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 572547000344 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 572547000345 substrate binding site [chemical binding]; other site 572547000346 ligand binding site [chemical binding]; other site 572547000347 2-isopropylmalate synthase; Validated; Region: PRK00915 572547000348 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 572547000349 active site 572547000350 catalytic residues [active] 572547000351 metal binding site [ion binding]; metal-binding site 572547000352 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 572547000353 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 572547000354 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 572547000355 putative RNA binding site [nucleotide binding]; other site 572547000356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572547000357 S-adenosylmethionine binding site [chemical binding]; other site 572547000358 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 572547000359 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 572547000360 N-acetyl-D-glucosamine binding site [chemical binding]; other site 572547000361 catalytic residue [active] 572547000362 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 572547000363 SLBB domain; Region: SLBB; pfam10531 572547000364 4Fe-4S binding domain; Region: Fer4; cl02805 572547000365 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 572547000366 FMN-binding domain; Region: FMN_bind; cl01081 572547000367 electron transport complex RsxE subunit; Provisional; Region: PRK12405 572547000368 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 572547000369 ferredoxin; Validated; Region: PRK07118 572547000370 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572547000371 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 572547000372 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846 572547000373 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 572547000374 ApbE family; Region: ApbE; pfam02424 572547000375 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 572547000376 amino acid carrier protein; Region: agcS; TIGR00835 572547000377 Uncharacterized conserved protein [Function unknown]; Region: COG1615 572547000378 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 572547000379 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 572547000380 homodimer interaction site [polypeptide binding]; other site 572547000381 cofactor binding site; other site 572547000382 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 572547000383 homotrimer interaction site [polypeptide binding]; other site 572547000384 putative active site [active] 572547000385 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 572547000386 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 572547000387 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572547000388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547000389 homodimer interface [polypeptide binding]; other site 572547000390 catalytic residue [active] 572547000391 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 572547000392 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 572547000393 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 572547000394 active site 572547000395 dimer interface [polypeptide binding]; other site 572547000396 effector binding site; other site 572547000397 TSCPD domain; Region: TSCPD; pfam12637 572547000398 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 572547000399 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 572547000400 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 572547000401 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 572547000402 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 572547000403 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 572547000404 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 572547000405 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 572547000406 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 572547000407 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl09782 572547000408 Transcriptional regulators [Transcription]; Region: FadR; COG2186 572547000409 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572547000410 DNA-binding site [nucleotide binding]; DNA binding site 572547000411 FCD domain; Region: FCD; pfam07729 572547000412 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 572547000413 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 572547000414 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 572547000415 DctM-like transporters; Region: DctM; pfam06808 572547000416 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 572547000417 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 572547000418 Fumarase C-terminus; Region: Fumerase_C; cl00795 572547000419 fumarate hydratase; Reviewed; Region: fumC; PRK00485 572547000420 Class II fumarases; Region: Fumarase_classII; cd01362 572547000421 active site 572547000422 tetramer interface [polypeptide binding]; other site 572547000423 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 572547000424 Malic enzyme, N-terminal domain; Region: malic; pfam00390 572547000425 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 572547000426 putative NAD(P) binding site [chemical binding]; other site 572547000427 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 572547000428 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901 572547000429 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 572547000430 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 572547000431 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 572547000432 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 572547000433 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 572547000434 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 572547000435 putative active site [active] 572547000436 aspartate aminotransferase; Provisional; Region: PRK05764 572547000437 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572547000438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547000439 homodimer interface [polypeptide binding]; other site 572547000440 catalytic residue [active] 572547000441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 572547000442 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 572547000443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 572547000444 4-hydroxy-2-oxovalerate aldolase; Region: 4OH_2_O_val_ald; TIGR03217 572547000445 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 572547000446 active site 572547000447 catalytic residues [active] 572547000448 metal binding site [ion binding]; metal-binding site 572547000449 S-adenosylmethionine synthetase; Validated; Region: PRK05250 572547000450 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 572547000451 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 572547000452 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 572547000453 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 572547000454 PQQ-like domain; Region: PQQ_2; pfam13360 572547000455 Trp docking motif [polypeptide binding]; other site 572547000456 active site 572547000457 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 572547000458 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 572547000459 CPxP motif; other site 572547000460 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 572547000461 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 572547000462 FMN binding site [chemical binding]; other site 572547000463 substrate binding site [chemical binding]; other site 572547000464 putative catalytic residue [active] 572547000465 Mechanosensitive ion channel; Region: MS_channel; pfam00924 572547000466 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 572547000467 metal binding site [ion binding]; metal-binding site 572547000468 Uncharacterized conserved protein [Function unknown]; Region: COG1915 572547000469 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 572547000470 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 572547000471 putative ligand binding site [chemical binding]; other site 572547000472 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 572547000473 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 572547000474 TM-ABC transporter signature motif; other site 572547000475 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 572547000476 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 572547000477 TM-ABC transporter signature motif; other site 572547000478 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 572547000479 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 572547000480 Walker A/P-loop; other site 572547000481 ATP binding site [chemical binding]; other site 572547000482 Q-loop/lid; other site 572547000483 ABC transporter signature motif; other site 572547000484 Walker B; other site 572547000485 D-loop; other site 572547000486 H-loop/switch region; other site 572547000487 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 572547000488 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 572547000489 Walker A/P-loop; other site 572547000490 ATP binding site [chemical binding]; other site 572547000491 Q-loop/lid; other site 572547000492 ABC transporter signature motif; other site 572547000493 Walker B; other site 572547000494 D-loop; other site 572547000495 H-loop/switch region; other site 572547000496 transaminase; Validated; Region: PRK07324 572547000497 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572547000498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547000499 homodimer interface [polypeptide binding]; other site 572547000500 catalytic residue [active] 572547000501 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 572547000502 MoaE interaction surface [polypeptide binding]; other site 572547000503 MoeB interaction surface [polypeptide binding]; other site 572547000504 thiocarboxylated glycine; other site 572547000505 Transcriptional regulator; Region: Rrf2; cl17282 572547000506 Rrf2 family protein; Region: rrf2_super; TIGR00738 572547000507 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 572547000508 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 572547000509 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572547000510 catalytic residue [active] 572547000511 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 572547000512 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 572547000513 trimerization site [polypeptide binding]; other site 572547000514 active site 572547000515 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 572547000516 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 572547000517 ATP binding site [chemical binding]; other site 572547000518 substrate interface [chemical binding]; other site 572547000519 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 572547000520 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 572547000521 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 572547000522 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 572547000523 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 572547000524 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 572547000525 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 572547000526 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 572547000527 HSP70 interaction site [polypeptide binding]; other site 572547000528 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 572547000529 substrate binding site [polypeptide binding]; other site 572547000530 dimer interface [polypeptide binding]; other site 572547000531 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 572547000532 Transglycosylase; Region: Transgly; pfam00912 572547000533 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 572547000534 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 572547000535 Bacterial Ig-like domain; Region: Big_5; pfam13205 572547000536 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 572547000537 MG2 domain; Region: A2M_N; pfam01835 572547000538 Alpha-2-macroglobulin family; Region: A2M; pfam00207 572547000539 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 572547000540 surface patch; other site 572547000541 thioester region; other site 572547000542 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 572547000543 Clp amino terminal domain; Region: Clp_N; pfam02861 572547000544 Clp amino terminal domain; Region: Clp_N; pfam02861 572547000545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572547000546 Walker A motif; other site 572547000547 ATP binding site [chemical binding]; other site 572547000548 Walker B motif; other site 572547000549 arginine finger; other site 572547000550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572547000551 Walker A motif; other site 572547000552 ATP binding site [chemical binding]; other site 572547000553 Walker B motif; other site 572547000554 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 572547000555 Peptidase family C69; Region: Peptidase_C69; cl17793 572547000556 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572547000557 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572547000558 substrate binding pocket [chemical binding]; other site 572547000559 membrane-bound complex binding site; other site 572547000560 hinge residues; other site 572547000561 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 572547000562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572547000563 putative active site [active] 572547000564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572547000565 ATP binding site [chemical binding]; other site 572547000566 Mg2+ binding site [ion binding]; other site 572547000567 G-X-G motif; other site 572547000568 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 572547000569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572547000570 active site 572547000571 phosphorylation site [posttranslational modification] 572547000572 intermolecular recognition site; other site 572547000573 dimerization interface [polypeptide binding]; other site 572547000574 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 572547000575 DDE domain; Region: DDE_Tnp_IS240; pfam13610 572547000576 Peptidase family C69; Region: Peptidase_C69; cl17793 572547000577 Cupin domain; Region: Cupin_2; pfam07883 572547000578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572547000579 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572547000580 putative substrate translocation pore; other site 572547000581 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 572547000582 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 572547000583 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572547000584 FeS/SAM binding site; other site 572547000585 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 572547000586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572547000587 Coenzyme A binding pocket [chemical binding]; other site 572547000588 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 572547000589 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572547000590 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 572547000591 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572547000592 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 572547000593 Uncharacterized conserved protein [Function unknown]; Region: COG3461 572547000594 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 572547000595 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 572547000596 putative dimer interface [polypeptide binding]; other site 572547000597 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 572547000598 oligoendopeptidase F; Region: pepF; TIGR00181 572547000599 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 572547000600 active site 572547000601 Zn binding site [ion binding]; other site 572547000602 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572547000603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572547000604 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 572547000605 dimerization interface [polypeptide binding]; other site 572547000606 peptidase; Reviewed; Region: PRK13004 572547000607 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 572547000608 metal binding site [ion binding]; metal-binding site 572547000609 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 572547000610 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 572547000611 dimer interface [polypeptide binding]; other site 572547000612 active site 572547000613 glycine-pyridoxal phosphate binding site [chemical binding]; other site 572547000614 folate binding site [chemical binding]; other site 572547000615 cysteine synthase; Region: PLN02565 572547000616 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 572547000617 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572547000618 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 572547000619 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 572547000620 DctM-like transporters; Region: DctM; pfam06808 572547000621 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 572547000622 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 572547000623 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572547000624 active site 572547000625 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572547000626 peptidase; Reviewed; Region: PRK13004 572547000627 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 572547000628 putative metal binding site [ion binding]; other site 572547000629 putative dimer interface [polypeptide binding]; other site 572547000630 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 572547000631 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 572547000632 putative substrate binding site [chemical binding]; other site 572547000633 nucleotide binding site [chemical binding]; other site 572547000634 nucleotide binding site [chemical binding]; other site 572547000635 homodimer interface [polypeptide binding]; other site 572547000636 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 572547000637 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 572547000638 active site 572547000639 putative substrate binding pocket [chemical binding]; other site 572547000640 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572547000641 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 572547000642 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 572547000643 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 572547000644 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 572547000645 DctM-like transporters; Region: DctM; pfam06808 572547000646 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 572547000647 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 572547000648 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 572547000649 active site 572547000650 putative substrate binding pocket [chemical binding]; other site 572547000651 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572547000652 alanine racemase; Reviewed; Region: alr; PRK00053 572547000653 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 572547000654 active site 572547000655 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572547000656 dimer interface [polypeptide binding]; other site 572547000657 substrate binding site [chemical binding]; other site 572547000658 catalytic residues [active] 572547000659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572547000660 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572547000661 putative substrate translocation pore; other site 572547000662 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 572547000663 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 572547000664 G1 box; other site 572547000665 GTP/Mg2+ binding site [chemical binding]; other site 572547000666 Switch I region; other site 572547000667 G2 box; other site 572547000668 G3 box; other site 572547000669 Switch II region; other site 572547000670 G4 box; other site 572547000671 G5 box; other site 572547000672 Nucleoside recognition; Region: Gate; pfam07670 572547000673 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 572547000674 Nucleoside recognition; Region: Gate; pfam07670 572547000675 FeoA domain; Region: FeoA; pfam04023 572547000676 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14469 572547000677 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572547000678 FeS/SAM binding site; other site 572547000679 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 572547000680 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 572547000681 [2Fe-2S] cluster binding site [ion binding]; other site 572547000682 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 572547000683 ZIP Zinc transporter; Region: Zip; pfam02535 572547000684 Predicted membrane protein [Function unknown]; Region: COG1971 572547000685 Domain of unknown function DUF; Region: DUF204; pfam02659 572547000686 Domain of unknown function DUF; Region: DUF204; pfam02659 572547000687 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 572547000688 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 572547000689 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 572547000690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572547000691 Response regulator receiver domain; Region: Response_reg; pfam00072 572547000692 active site 572547000693 phosphorylation site [posttranslational modification] 572547000694 intermolecular recognition site; other site 572547000695 dimerization interface [polypeptide binding]; other site 572547000696 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 572547000697 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572547000698 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572547000699 substrate binding pocket [chemical binding]; other site 572547000700 membrane-bound complex binding site; other site 572547000701 hinge residues; other site 572547000702 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 572547000703 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572547000704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547000705 homodimer interface [polypeptide binding]; other site 572547000706 catalytic residue [active] 572547000707 diaminopimelate decarboxylase; Region: lysA; TIGR01048 572547000708 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 572547000709 active site 572547000710 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572547000711 substrate binding site [chemical binding]; other site 572547000712 catalytic residues [active] 572547000713 dimer interface [polypeptide binding]; other site 572547000714 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 572547000715 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 572547000716 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 572547000717 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 572547000718 glycogen synthase; Provisional; Region: glgA; PRK00654 572547000719 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 572547000720 ADP-binding pocket [chemical binding]; other site 572547000721 homodimer interface [polypeptide binding]; other site 572547000722 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 572547000723 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 572547000724 4-alpha-glucanotransferase; Provisional; Region: PRK14508 572547000725 glycogen branching enzyme; Provisional; Region: PRK12313 572547000726 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 572547000727 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 572547000728 active site 572547000729 catalytic site [active] 572547000730 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 572547000731 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 572547000732 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 572547000733 active site 572547000734 catalytic site [active] 572547000735 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 572547000736 gamma-glutamyl kinase; Provisional; Region: PRK05429 572547000737 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 572547000738 nucleotide binding site [chemical binding]; other site 572547000739 homotetrameric interface [polypeptide binding]; other site 572547000740 putative phosphate binding site [ion binding]; other site 572547000741 putative allosteric binding site; other site 572547000742 PUA domain; Region: PUA; pfam01472 572547000743 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 572547000744 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 572547000745 putative catalytic cysteine [active] 572547000746 Protein of unknown function (DUF554); Region: DUF554; pfam04474 572547000747 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 572547000748 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 572547000749 TM-ABC transporter signature motif; other site 572547000750 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 572547000751 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 572547000752 TM-ABC transporter signature motif; other site 572547000753 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 572547000754 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 572547000755 Walker A/P-loop; other site 572547000756 ATP binding site [chemical binding]; other site 572547000757 Q-loop/lid; other site 572547000758 ABC transporter signature motif; other site 572547000759 Walker B; other site 572547000760 D-loop; other site 572547000761 H-loop/switch region; other site 572547000762 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 572547000763 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 572547000764 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 572547000765 putative ligand binding site [chemical binding]; other site 572547000766 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572547000767 active site 572547000768 intracellular protease, PfpI family; Region: PfpI; TIGR01382 572547000769 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 572547000770 proposed catalytic triad [active] 572547000771 conserved cys residue [active] 572547000772 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572547000773 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 572547000774 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 572547000775 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 572547000776 active site 572547000777 homotetramer interface [polypeptide binding]; other site 572547000778 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 572547000779 putative FMN binding site [chemical binding]; other site 572547000780 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 572547000781 putative FMN binding site [chemical binding]; other site 572547000782 DNA gyrase subunit A; Validated; Region: PRK05560 572547000783 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 572547000784 CAP-like domain; other site 572547000785 active site 572547000786 primary dimer interface [polypeptide binding]; other site 572547000787 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572547000788 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572547000789 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572547000790 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572547000791 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572547000792 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 572547000793 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 572547000794 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 572547000795 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 572547000796 dimer interface [polypeptide binding]; other site 572547000797 substrate binding site [chemical binding]; other site 572547000798 ATP binding site [chemical binding]; other site 572547000799 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 572547000800 substrate binding site [chemical binding]; other site 572547000801 multimerization interface [polypeptide binding]; other site 572547000802 ATP binding site [chemical binding]; other site 572547000803 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 572547000804 thiamine phosphate binding site [chemical binding]; other site 572547000805 active site 572547000806 pyrophosphate binding site [ion binding]; other site 572547000807 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 572547000808 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 572547000809 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 572547000810 NMT1/THI5 like; Region: NMT1; pfam09084 572547000811 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 572547000812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547000813 dimer interface [polypeptide binding]; other site 572547000814 conserved gate region; other site 572547000815 putative PBP binding loops; other site 572547000816 ABC-ATPase subunit interface; other site 572547000817 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 572547000818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572547000819 Walker A/P-loop; other site 572547000820 ATP binding site [chemical binding]; other site 572547000821 Q-loop/lid; other site 572547000822 ABC transporter signature motif; other site 572547000823 Walker B; other site 572547000824 D-loop; other site 572547000825 H-loop/switch region; other site 572547000826 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 572547000827 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 572547000828 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572547000829 Ligand Binding Site [chemical binding]; other site 572547000830 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572547000831 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 572547000832 dimer interface [polypeptide binding]; other site 572547000833 substrate binding site [chemical binding]; other site 572547000834 metal binding site [ion binding]; metal-binding site 572547000835 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 572547000836 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 572547000837 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 572547000838 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 572547000839 carboxyltransferase (CT) interaction site; other site 572547000840 biotinylation site [posttranslational modification]; other site 572547000841 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 572547000842 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 572547000843 Sugar fermentation stimulation protein; Region: SfsA; cl00647 572547000844 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572547000845 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572547000846 Ligand Binding Site [chemical binding]; other site 572547000847 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 572547000848 putative acyl-acceptor binding pocket; other site 572547000849 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 572547000850 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 572547000851 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 572547000852 Cl- selectivity filter; other site 572547000853 Cl- binding residues [ion binding]; other site 572547000854 pore gating glutamate residue; other site 572547000855 dimer interface [polypeptide binding]; other site 572547000856 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 572547000857 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 572547000858 hypothetical protein; Provisional; Region: PRK10279 572547000859 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 572547000860 active site 572547000861 nucleophile elbow; other site 572547000862 prolyl-tRNA synthetase; Provisional; Region: PRK08661 572547000863 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 572547000864 dimer interface [polypeptide binding]; other site 572547000865 motif 1; other site 572547000866 active site 572547000867 motif 2; other site 572547000868 motif 3; other site 572547000869 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 572547000870 anticodon binding site; other site 572547000871 zinc-binding site [ion binding]; other site 572547000872 exopolyphosphatase; Region: exo_poly_only; TIGR03706 572547000873 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 572547000874 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 572547000875 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 572547000876 PhoU domain; Region: PhoU; pfam01895 572547000877 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 572547000878 PhoU domain; Region: PhoU; pfam01895 572547000879 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572547000880 active site residue [active] 572547000881 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 572547000882 putative FMN binding site [chemical binding]; other site 572547000883 Class I aldolases; Region: Aldolase_Class_I; cl17187 572547000884 homoserine dehydrogenase; Provisional; Region: PRK06270 572547000885 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 572547000886 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 572547000887 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 572547000888 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572547000889 active site 572547000890 metal binding site [ion binding]; metal-binding site 572547000891 homotetramer interface [polypeptide binding]; other site 572547000892 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 572547000893 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 572547000894 active site 572547000895 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 572547000896 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 572547000897 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 572547000898 tetramer interface [polypeptide binding]; other site 572547000899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547000900 catalytic residue [active] 572547000901 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 572547000902 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 572547000903 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 572547000904 active site 572547000905 metal binding site [ion binding]; metal-binding site 572547000906 Sporulation and spore germination; Region: Germane; pfam10646 572547000907 ribonuclease PH; Reviewed; Region: rph; PRK00173 572547000908 Ribonuclease PH; Region: RNase_PH_bact; cd11362 572547000909 hexamer interface [polypeptide binding]; other site 572547000910 active site 572547000911 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 572547000912 active site 572547000913 dimerization interface [polypeptide binding]; other site 572547000914 Preprotein translocase SecG subunit; Region: SecG; pfam03840 572547000915 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 572547000916 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 572547000917 active site 572547000918 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 572547000919 23S rRNA interface [nucleotide binding]; other site 572547000920 L3 interface [polypeptide binding]; other site 572547000921 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 572547000922 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 572547000923 MgtE intracellular N domain; Region: MgtE_N; pfam03448 572547000924 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 572547000925 Divalent cation transporter; Region: MgtE; pfam01769 572547000926 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572547000927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572547000928 Outer membrane efflux protein; Region: OEP; pfam02321 572547000929 Outer membrane efflux protein; Region: OEP; pfam02321 572547000930 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 572547000931 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 572547000932 HlyD family secretion protein; Region: HlyD_3; pfam13437 572547000933 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 572547000934 Protein export membrane protein; Region: SecD_SecF; cl14618 572547000935 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 572547000936 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 572547000937 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572547000938 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572547000939 DNA binding residues [nucleotide binding] 572547000940 elongation factor Tu; Reviewed; Region: PRK00049 572547000941 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 572547000942 G1 box; other site 572547000943 GEF interaction site [polypeptide binding]; other site 572547000944 GTP/Mg2+ binding site [chemical binding]; other site 572547000945 Switch I region; other site 572547000946 G2 box; other site 572547000947 G3 box; other site 572547000948 Switch II region; other site 572547000949 G4 box; other site 572547000950 G5 box; other site 572547000951 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 572547000952 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 572547000953 Antibiotic Binding Site [chemical binding]; other site 572547000954 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 572547000955 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 572547000956 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 572547000957 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 572547000958 putative homodimer interface [polypeptide binding]; other site 572547000959 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 572547000960 heterodimer interface [polypeptide binding]; other site 572547000961 homodimer interface [polypeptide binding]; other site 572547000962 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 572547000963 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 572547000964 23S rRNA interface [nucleotide binding]; other site 572547000965 L7/L12 interface [polypeptide binding]; other site 572547000966 putative thiostrepton binding site; other site 572547000967 L25 interface [polypeptide binding]; other site 572547000968 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 572547000969 mRNA/rRNA interface [nucleotide binding]; other site 572547000970 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 572547000971 23S rRNA interface [nucleotide binding]; other site 572547000972 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 572547000973 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 572547000974 core dimer interface [polypeptide binding]; other site 572547000975 peripheral dimer interface [polypeptide binding]; other site 572547000976 L10 interface [polypeptide binding]; other site 572547000977 L11 interface [polypeptide binding]; other site 572547000978 putative EF-Tu interaction site [polypeptide binding]; other site 572547000979 putative EF-G interaction site [polypeptide binding]; other site 572547000980 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 572547000981 Active_site [active] 572547000982 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572547000983 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 572547000984 Predicted integral membrane protein [Function unknown]; Region: COG0392 572547000985 Uncharacterized conserved protein [Function unknown]; Region: COG2898 572547000986 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 572547000987 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 572547000988 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 572547000989 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 572547000990 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572547000991 B12 binding site [chemical binding]; other site 572547000992 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 572547000993 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 572547000994 FeS/SAM binding site; other site 572547000995 Predicted permeases [General function prediction only]; Region: RarD; COG2962 572547000996 EamA-like transporter family; Region: EamA; cl17759 572547000997 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 572547000998 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 572547000999 minor groove reading motif; other site 572547001000 helix-hairpin-helix signature motif; other site 572547001001 substrate binding pocket [chemical binding]; other site 572547001002 active site 572547001003 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 572547001004 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 572547001005 DNA binding and oxoG recognition site [nucleotide binding] 572547001006 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 572547001007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572547001008 S-adenosylmethionine binding site [chemical binding]; other site 572547001009 Cyclophilin-like; Region: Cyclophil_like; pfam04126 572547001010 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 572547001011 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 572547001012 N-terminal plug; other site 572547001013 ligand-binding site [chemical binding]; other site 572547001014 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 572547001015 putative ligand binding site [chemical binding]; other site 572547001016 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 572547001017 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572547001018 ABC-ATPase subunit interface; other site 572547001019 dimer interface [polypeptide binding]; other site 572547001020 putative PBP binding regions; other site 572547001021 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 572547001022 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 572547001023 Walker A/P-loop; other site 572547001024 ATP binding site [chemical binding]; other site 572547001025 Q-loop/lid; other site 572547001026 ABC transporter signature motif; other site 572547001027 Walker B; other site 572547001028 D-loop; other site 572547001029 H-loop/switch region; other site 572547001030 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 572547001031 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 572547001032 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 572547001033 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 572547001034 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 572547001035 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 572547001036 Na2 binding site [ion binding]; other site 572547001037 putative substrate binding site 1 [chemical binding]; other site 572547001038 Na binding site 1 [ion binding]; other site 572547001039 putative substrate binding site 2 [chemical binding]; other site 572547001040 spermidine synthase; Provisional; Region: PRK00811 572547001041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 572547001042 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 572547001043 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 572547001044 dimer interface [polypeptide binding]; other site 572547001045 active site 572547001046 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572547001047 catalytic residues [active] 572547001048 substrate binding site [chemical binding]; other site 572547001049 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572547001050 glucokinase, proteobacterial type; Region: glk; TIGR00749 572547001051 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 572547001052 nucleotide binding site [chemical binding]; other site 572547001053 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 572547001054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572547001055 S-adenosylmethionine binding site [chemical binding]; other site 572547001056 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 572547001057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572547001058 Walker A/P-loop; other site 572547001059 ATP binding site [chemical binding]; other site 572547001060 Q-loop/lid; other site 572547001061 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572547001062 ABC transporter signature motif; other site 572547001063 Walker B; other site 572547001064 D-loop; other site 572547001065 ABC transporter; Region: ABC_tran_2; pfam12848 572547001066 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572547001067 ABC transporter; Region: ABC_tran_2; pfam12848 572547001068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572547001069 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 572547001070 putative substrate translocation pore; other site 572547001071 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 572547001072 DNA-binding site [nucleotide binding]; DNA binding site 572547001073 RNA-binding motif; other site 572547001074 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 572547001075 DEAD-like helicases superfamily; Region: DEXDc; smart00487 572547001076 ATP binding site [chemical binding]; other site 572547001077 Mg++ binding site [ion binding]; other site 572547001078 motif III; other site 572547001079 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572547001080 nucleotide binding region [chemical binding]; other site 572547001081 ATP-binding site [chemical binding]; other site 572547001082 DbpA RNA binding domain; Region: DbpA; pfam03880 572547001083 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 572547001084 HlyD family secretion protein; Region: HlyD_3; pfam13437 572547001085 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 572547001086 Protein export membrane protein; Region: SecD_SecF; cl14618 572547001087 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 572547001088 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 572547001089 N-acetyl-D-glucosamine binding site [chemical binding]; other site 572547001090 catalytic residue [active] 572547001091 EamA-like transporter family; Region: EamA; pfam00892 572547001092 EamA-like transporter family; Region: EamA; pfam00892 572547001093 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 572547001094 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 572547001095 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 572547001096 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 572547001097 ligand binding site [chemical binding]; other site 572547001098 Transcriptional regulators [Transcription]; Region: PurR; COG1609 572547001099 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 572547001100 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 572547001101 Walker A/P-loop; other site 572547001102 ATP binding site [chemical binding]; other site 572547001103 Q-loop/lid; other site 572547001104 ABC transporter signature motif; other site 572547001105 Walker B; other site 572547001106 D-loop; other site 572547001107 H-loop/switch region; other site 572547001108 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 572547001109 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 572547001110 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 572547001111 TM-ABC transporter signature motif; other site 572547001112 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 572547001113 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 572547001114 TM-ABC transporter signature motif; other site 572547001115 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 572547001116 putative FMN binding site [chemical binding]; other site 572547001117 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 572547001118 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 572547001119 trmE is a tRNA modification GTPase; Region: trmE; cd04164 572547001120 G1 box; other site 572547001121 GTP/Mg2+ binding site [chemical binding]; other site 572547001122 Switch I region; other site 572547001123 G2 box; other site 572547001124 Switch II region; other site 572547001125 G3 box; other site 572547001126 G4 box; other site 572547001127 G5 box; other site 572547001128 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 572547001129 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 572547001130 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572547001131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547001132 homodimer interface [polypeptide binding]; other site 572547001133 catalytic residue [active] 572547001134 Peptidase family M48; Region: Peptidase_M48; cl12018 572547001135 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 572547001136 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 572547001137 N-acetyl-D-glucosamine binding site [chemical binding]; other site 572547001138 catalytic residue [active] 572547001139 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 572547001140 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 572547001141 Cell division protein 48 (CDC48) domain 2; Region: CDC48_2; smart01072 572547001142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572547001143 Walker A motif; other site 572547001144 ATP binding site [chemical binding]; other site 572547001145 Walker B motif; other site 572547001146 arginine finger; other site 572547001147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572547001148 Walker A motif; other site 572547001149 ATP binding site [chemical binding]; other site 572547001150 Walker B motif; other site 572547001151 arginine finger; other site 572547001152 aspartate aminotransferase; Provisional; Region: PRK07568 572547001153 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572547001154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547001155 homodimer interface [polypeptide binding]; other site 572547001156 catalytic residue [active] 572547001157 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135 572547001158 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 572547001159 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 572547001160 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 572547001161 generic binding surface I; other site 572547001162 generic binding surface II; other site 572547001163 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572547001164 Zn2+ binding site [ion binding]; other site 572547001165 Mg2+ binding site [ion binding]; other site 572547001166 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 572547001167 S4 RNA-binding domain; Region: S4; smart00363 572547001168 RNA binding surface [nucleotide binding]; other site 572547001169 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 572547001170 active site 572547001171 conjugal transfer coupling protein TraG; Provisional; Region: PRK13880 572547001172 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 572547001173 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 572547001174 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 572547001175 NAD(P) binding site [chemical binding]; other site 572547001176 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 572547001177 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 572547001178 putative dimer interface [polypeptide binding]; other site 572547001179 putative anticodon binding site; other site 572547001180 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 572547001181 homodimer interface [polypeptide binding]; other site 572547001182 motif 1; other site 572547001183 motif 2; other site 572547001184 active site 572547001185 motif 3; other site 572547001186 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 572547001187 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572547001188 acyl-activating enzyme (AAE) consensus motif; other site 572547001189 AMP binding site [chemical binding]; other site 572547001190 active site 572547001191 CoA binding site [chemical binding]; other site 572547001192 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 572547001193 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 572547001194 putative ribose interaction site [chemical binding]; other site 572547001195 putative ADP binding site [chemical binding]; other site 572547001196 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 572547001197 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 572547001198 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572547001199 DNA-binding site [nucleotide binding]; DNA binding site 572547001200 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572547001201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547001202 homodimer interface [polypeptide binding]; other site 572547001203 catalytic residue [active] 572547001204 Transcriptional regulators [Transcription]; Region: GntR; COG1802 572547001205 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572547001206 DNA-binding site [nucleotide binding]; DNA binding site 572547001207 FCD domain; Region: FCD; pfam07729 572547001208 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 572547001209 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 572547001210 inhibitor-cofactor binding pocket; inhibition site 572547001211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547001212 catalytic residue [active] 572547001213 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 572547001214 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 572547001215 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 572547001216 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 572547001217 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 572547001218 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 572547001219 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 572547001220 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 572547001221 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 572547001222 substrate binding site [chemical binding]; other site 572547001223 hexamer interface [polypeptide binding]; other site 572547001224 metal binding site [ion binding]; metal-binding site 572547001225 Helix-turn-helix domain; Region: HTH_25; pfam13413 572547001226 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 572547001227 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 572547001228 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 572547001229 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572547001230 FeS/SAM binding site; other site 572547001231 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 572547001232 tetramer interfaces [polypeptide binding]; other site 572547001233 binuclear metal-binding site [ion binding]; other site 572547001234 competence damage-inducible protein A; Provisional; Region: PRK00549 572547001235 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 572547001236 putative MPT binding site; other site 572547001237 Competence-damaged protein; Region: CinA; pfam02464 572547001238 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 572547001239 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 572547001240 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 572547001241 recombinase A; Provisional; Region: recA; PRK09354 572547001242 recA bacterial DNA recombination protein; Region: RecA; cl17211 572547001243 NAD-dependent deacetylase; Provisional; Region: PRK00481 572547001244 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 572547001245 NAD+ binding site [chemical binding]; other site 572547001246 substrate binding site [chemical binding]; other site 572547001247 Zn binding site [ion binding]; other site 572547001248 xanthine permease; Region: pbuX; TIGR03173 572547001249 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 572547001250 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 572547001251 HlyD family secretion protein; Region: HlyD_3; pfam13437 572547001252 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 572547001253 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 572547001254 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 572547001255 non-heme iron binding site [ion binding]; other site 572547001256 dimer interface [polypeptide binding]; other site 572547001257 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 572547001258 non-heme iron binding site [ion binding]; other site 572547001259 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 572547001260 Ferritin-like domain; Region: Ferritin; pfam00210 572547001261 ferroxidase diiron center [ion binding]; other site 572547001262 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 572547001263 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 572547001264 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572547001265 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 572547001266 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 572547001267 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 572547001268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572547001269 putative substrate translocation pore; other site 572547001270 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 572547001271 catalytic motif [active] 572547001272 Zn binding site [ion binding]; other site 572547001273 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 572547001274 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572547001275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572547001276 active site 572547001277 phosphorylation site [posttranslational modification] 572547001278 intermolecular recognition site; other site 572547001279 dimerization interface [polypeptide binding]; other site 572547001280 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572547001281 DNA binding residues [nucleotide binding] 572547001282 dimerization interface [polypeptide binding]; other site 572547001283 Histidine kinase; Region: HisKA_3; pfam07730 572547001284 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 572547001285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572547001286 ATP binding site [chemical binding]; other site 572547001287 Mg2+ binding site [ion binding]; other site 572547001288 G-X-G motif; other site 572547001289 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 572547001290 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572547001291 Beta-Casp domain; Region: Beta-Casp; smart01027 572547001292 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 572547001293 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 572547001294 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 572547001295 active site 572547001296 HIGH motif; other site 572547001297 dimer interface [polypeptide binding]; other site 572547001298 KMSKS motif; other site 572547001299 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572547001300 RNA binding surface [nucleotide binding]; other site 572547001301 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 572547001302 putative acyl-acceptor binding pocket; other site 572547001303 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 572547001304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547001305 dimer interface [polypeptide binding]; other site 572547001306 conserved gate region; other site 572547001307 putative PBP binding loops; other site 572547001308 ABC-ATPase subunit interface; other site 572547001309 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 572547001310 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 572547001311 Walker A/P-loop; other site 572547001312 ATP binding site [chemical binding]; other site 572547001313 Q-loop/lid; other site 572547001314 ABC transporter signature motif; other site 572547001315 Walker B; other site 572547001316 D-loop; other site 572547001317 H-loop/switch region; other site 572547001318 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572547001319 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 572547001320 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 572547001321 active site 572547001322 substrate binding site [chemical binding]; other site 572547001323 metal binding site [ion binding]; metal-binding site 572547001324 Predicted permeases [General function prediction only]; Region: COG0679 572547001325 YibE/F-like protein; Region: YibE_F; pfam07907 572547001326 Transcriptional regulators [Transcription]; Region: FadR; COG2186 572547001327 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572547001328 DNA-binding site [nucleotide binding]; DNA binding site 572547001329 FCD domain; Region: FCD; pfam07729 572547001330 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 572547001331 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 572547001332 active site 572547001333 Transcriptional regulators [Transcription]; Region: PurR; COG1609 572547001334 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 572547001335 DNA binding site [nucleotide binding] 572547001336 domain linker motif; other site 572547001337 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 572547001338 dimerization interface [polypeptide binding]; other site 572547001339 ligand binding site [chemical binding]; other site 572547001340 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 572547001341 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 572547001342 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 572547001343 conserved hypothetical protein; Region: TIGR02231 572547001344 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 572547001345 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 572547001346 GTP-binding protein YchF; Reviewed; Region: PRK09601 572547001347 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 572547001348 G1 box; other site 572547001349 GTP/Mg2+ binding site [chemical binding]; other site 572547001350 G2 box; other site 572547001351 Switch I region; other site 572547001352 G3 box; other site 572547001353 Switch II region; other site 572547001354 G4 box; other site 572547001355 G5 box; other site 572547001356 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 572547001357 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 572547001358 putative amphipathic alpha helix; other site 572547001359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572547001360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572547001361 ATP binding site [chemical binding]; other site 572547001362 Mg2+ binding site [ion binding]; other site 572547001363 G-X-G motif; other site 572547001364 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 572547001365 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 572547001366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572547001367 active site 572547001368 motif I; other site 572547001369 motif II; other site 572547001370 recombination factor protein RarA; Reviewed; Region: PRK13342 572547001371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572547001372 Walker A motif; other site 572547001373 ATP binding site [chemical binding]; other site 572547001374 Walker B motif; other site 572547001375 arginine finger; other site 572547001376 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 572547001377 Transcriptional regulators [Transcription]; Region: GntR; COG1802 572547001378 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572547001379 DNA-binding site [nucleotide binding]; DNA binding site 572547001380 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 572547001381 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 572547001382 Transcriptional regulator [Transcription]; Region: IclR; COG1414 572547001383 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 572547001384 Bacterial transcriptional regulator; Region: IclR; pfam01614 572547001385 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 572547001386 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 572547001387 tetramer interface [polypeptide binding]; other site 572547001388 active site 572547001389 Mg2+/Mn2+ binding site [ion binding]; other site 572547001390 hypothetical protein; Validated; Region: PRK06201 572547001391 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 572547001392 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 572547001393 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 572547001394 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 572547001395 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 572547001396 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 572547001397 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 572547001398 DctM-like transporters; Region: DctM; pfam06808 572547001399 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 572547001400 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 572547001401 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 572547001402 Coenzyme A transferase; Region: CoA_trans; cl17247 572547001403 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 572547001404 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 572547001405 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 572547001406 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 572547001407 HsdM N-terminal domain; Region: HsdM_N; pfam12161 572547001408 Methyltransferase domain; Region: Methyltransf_26; pfam13659 572547001409 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 572547001410 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 572547001411 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 572547001412 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 572547001413 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 572547001414 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 572547001415 ATP binding site [chemical binding]; other site 572547001416 putative Mg++ binding site [ion binding]; other site 572547001417 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 572547001418 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 572547001419 Predicted amidohydrolase [General function prediction only]; Region: COG0388 572547001420 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 572547001421 putative active site [active] 572547001422 catalytic triad [active] 572547001423 putative dimer interface [polypeptide binding]; other site 572547001424 Transcriptional regulators [Transcription]; Region: GntR; COG1802 572547001425 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572547001426 DNA-binding site [nucleotide binding]; DNA binding site 572547001427 FCD domain; Region: FCD; pfam07729 572547001428 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 572547001429 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 572547001430 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 572547001431 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 572547001432 DctM-like transporters; Region: DctM; pfam06808 572547001433 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 572547001434 methionine gamma-lyase; Provisional; Region: PRK06234 572547001435 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 572547001436 homodimer interface [polypeptide binding]; other site 572547001437 substrate-cofactor binding pocket; other site 572547001438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547001439 catalytic residue [active] 572547001440 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 572547001441 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 572547001442 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572547001443 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572547001444 motif II; other site 572547001445 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 572547001446 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 572547001447 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 572547001448 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 572547001449 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 572547001450 active site 572547001451 LssY C-terminus; Region: LssY_C; pfam14067 572547001452 potential frameshift: common BLAST hit: gi|292488643|ref|YP_003531527.1| putative ABC transport system, ATP-binding component 572547001453 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572547001454 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572547001455 Walker A/P-loop; other site 572547001456 ATP binding site [chemical binding]; other site 572547001457 Q-loop/lid; other site 572547001458 ABC transporter signature motif; other site 572547001459 Walker B; other site 572547001460 D-loop; other site 572547001461 H-loop/switch region; other site 572547001462 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 572547001463 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572547001464 Walker A/P-loop; other site 572547001465 ATP binding site [chemical binding]; other site 572547001466 Q-loop/lid; other site 572547001467 ABC transporter signature motif; other site 572547001468 Walker B; other site 572547001469 D-loop; other site 572547001470 H-loop/switch region; other site 572547001471 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 572547001472 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 572547001473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547001474 dimer interface [polypeptide binding]; other site 572547001475 conserved gate region; other site 572547001476 putative PBP binding loops; other site 572547001477 ABC-ATPase subunit interface; other site 572547001478 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 572547001479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 572547001480 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 572547001481 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 572547001482 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 572547001483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572547001484 S-adenosylmethionine binding site [chemical binding]; other site 572547001485 Radical SAM superfamily; Region: Radical_SAM; pfam04055 572547001486 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572547001487 FeS/SAM binding site; other site 572547001488 methionine sulfoxide reductase B; Provisional; Region: PRK00222 572547001489 SelR domain; Region: SelR; pfam01641 572547001490 classical (c) SDRs; Region: SDR_c; cd05233 572547001491 short chain dehydrogenase; Provisional; Region: PRK05650 572547001492 NAD(P) binding site [chemical binding]; other site 572547001493 active site 572547001494 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 572547001495 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 572547001496 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 572547001497 DNA binding site [nucleotide binding] 572547001498 active site 572547001499 Mechanosensitive ion channel; Region: MS_channel; pfam00924 572547001500 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 572547001501 EamA-like transporter family; Region: EamA; pfam00892 572547001502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 572547001503 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572547001504 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 572547001505 B3/4 domain; Region: B3_4; pfam03483 572547001506 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 572547001507 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 572547001508 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 572547001509 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 572547001510 HlyD family secretion protein; Region: HlyD_3; pfam13437 572547001511 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572547001512 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572547001513 Walker A/P-loop; other site 572547001514 ATP binding site [chemical binding]; other site 572547001515 Q-loop/lid; other site 572547001516 ABC transporter signature motif; other site 572547001517 Walker B; other site 572547001518 D-loop; other site 572547001519 H-loop/switch region; other site 572547001520 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572547001521 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 572547001522 FtsX-like permease family; Region: FtsX; pfam02687 572547001523 homoserine dehydrogenase; Provisional; Region: PRK06270 572547001524 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 572547001525 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 572547001526 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052 572547001527 Ferritin-like domain; Region: Ferritin; pfam00210 572547001528 diiron binding motif [ion binding]; other site 572547001529 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 572547001530 DNA-binding site [nucleotide binding]; DNA binding site 572547001531 RNA-binding motif; other site 572547001532 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 572547001533 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 572547001534 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 572547001535 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 572547001536 putative active site [active] 572547001537 hypothetical protein; Provisional; Region: PRK05463 572547001538 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 572547001539 intersubunit interface [polypeptide binding]; other site 572547001540 active site 572547001541 Zn2+ binding site [ion binding]; other site 572547001542 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 572547001543 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 572547001544 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 572547001545 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 572547001546 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 572547001547 DctM-like transporters; Region: DctM; pfam06808 572547001548 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 572547001549 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572547001550 membrane-bound complex binding site; other site 572547001551 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572547001552 Transcriptional regulators [Transcription]; Region: FadR; COG2186 572547001553 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572547001554 DNA-binding site [nucleotide binding]; DNA binding site 572547001555 FCD domain; Region: FCD; pfam07729 572547001556 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 572547001557 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 572547001558 dimer interface [polypeptide binding]; other site 572547001559 PYR/PP interface [polypeptide binding]; other site 572547001560 TPP binding site [chemical binding]; other site 572547001561 substrate binding site [chemical binding]; other site 572547001562 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572547001563 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 572547001564 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 572547001565 TPP-binding site [chemical binding]; other site 572547001566 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 572547001567 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 572547001568 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 572547001569 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 572547001570 CoA-ligase; Region: Ligase_CoA; pfam00549 572547001571 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 572547001572 CoA binding domain; Region: CoA_binding; pfam02629 572547001573 CoA-ligase; Region: Ligase_CoA; pfam00549 572547001574 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 572547001575 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 572547001576 aspartate aminotransferase; Provisional; Region: PRK05764 572547001577 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572547001578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547001579 homodimer interface [polypeptide binding]; other site 572547001580 catalytic residue [active] 572547001581 homoserine dehydrogenase; Provisional; Region: PRK06270 572547001582 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 572547001583 NAD(P) binding pocket [chemical binding]; other site 572547001584 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 572547001585 putative inner membrane protein; Provisional; Region: PRK11099 572547001586 EamA-like transporter family; Region: EamA; pfam00892 572547001587 EamA-like transporter family; Region: EamA; pfam00892 572547001588 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 572547001589 homotrimer interaction site [polypeptide binding]; other site 572547001590 putative active site [active] 572547001591 Predicted membrane protein [Function unknown]; Region: COG2855 572547001592 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572547001593 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572547001594 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 572547001595 putative dimerization interface [polypeptide binding]; other site 572547001596 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 572547001597 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 572547001598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547001599 catalytic residue [active] 572547001600 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 572547001601 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572547001602 acyl-activating enzyme (AAE) consensus motif; other site 572547001603 active site 572547001604 AMP binding site [chemical binding]; other site 572547001605 CoA binding site [chemical binding]; other site 572547001606 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 572547001607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572547001608 S-adenosylmethionine binding site [chemical binding]; other site 572547001609 PAS domain; Region: PAS_9; pfam13426 572547001610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572547001611 putative active site [active] 572547001612 heme pocket [chemical binding]; other site 572547001613 PAS fold; Region: PAS_3; pfam08447 572547001614 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 572547001615 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572547001616 Zn2+ binding site [ion binding]; other site 572547001617 Mg2+ binding site [ion binding]; other site 572547001618 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 572547001619 PAS domain S-box; Region: sensory_box; TIGR00229 572547001620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572547001621 putative active site [active] 572547001622 heme pocket [chemical binding]; other site 572547001623 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 572547001624 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572547001625 Zn2+ binding site [ion binding]; other site 572547001626 Mg2+ binding site [ion binding]; other site 572547001627 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 572547001628 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 572547001629 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 572547001630 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 572547001631 RNA binding site [nucleotide binding]; other site 572547001632 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 572547001633 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 572547001634 active site 572547001635 metal binding site [ion binding]; metal-binding site 572547001636 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 572547001637 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 572547001638 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 572547001639 dimer interface [polypeptide binding]; other site 572547001640 motif 1; other site 572547001641 active site 572547001642 motif 2; other site 572547001643 motif 3; other site 572547001644 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 572547001645 anticodon binding site; other site 572547001646 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 572547001647 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 572547001648 dimer interface [polypeptide binding]; other site 572547001649 anticodon binding site; other site 572547001650 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 572547001651 homodimer interface [polypeptide binding]; other site 572547001652 motif 1; other site 572547001653 active site 572547001654 motif 2; other site 572547001655 GAD domain; Region: GAD; pfam02938 572547001656 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 572547001657 motif 3; other site 572547001658 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 572547001659 metal-dependent hydrolase; Provisional; Region: PRK00685 572547001660 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 572547001661 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 572547001662 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 572547001663 putative active site [active] 572547001664 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 572547001665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572547001666 FeS/SAM binding site; other site 572547001667 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572547001668 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572547001669 non-specific DNA binding site [nucleotide binding]; other site 572547001670 salt bridge; other site 572547001671 sequence-specific DNA binding site [nucleotide binding]; other site 572547001672 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572547001673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572547001674 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 572547001675 putative dimerization interface [polypeptide binding]; other site 572547001676 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 572547001677 putative deacylase active site [active] 572547001678 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 572547001679 trimer interface [polypeptide binding]; other site 572547001680 putative Zn binding site [ion binding]; other site 572547001681 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 572547001682 active site 572547001683 homotetramer interface [polypeptide binding]; other site 572547001684 homodimer interface [polypeptide binding]; other site 572547001685 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 572547001686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 572547001687 signal recognition particle protein; Provisional; Region: PRK10867 572547001688 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 572547001689 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 572547001690 P loop; other site 572547001691 GTP binding site [chemical binding]; other site 572547001692 Signal peptide binding domain; Region: SRP_SPB; pfam02978 572547001693 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 572547001694 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 572547001695 KH domain; Region: KH_4; pfam13083 572547001696 G-X-X-G motif; other site 572547001697 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 572547001698 RimM N-terminal domain; Region: RimM; pfam01782 572547001699 PRC-barrel domain; Region: PRC; pfam05239 572547001700 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 572547001701 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; cl17853 572547001702 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 572547001703 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 572547001704 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 572547001705 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 572547001706 Uncharacterized conserved protein [Function unknown]; Region: COG1656 572547001707 Protein of unknown function DUF82; Region: DUF82; pfam01927 572547001708 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 572547001709 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 572547001710 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 572547001711 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 572547001712 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 572547001713 Clp protease ATP binding subunit; Region: clpC; CHL00095 572547001714 Clp amino terminal domain; Region: Clp_N; pfam02861 572547001715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572547001716 Walker A motif; other site 572547001717 ATP binding site [chemical binding]; other site 572547001718 Walker B motif; other site 572547001719 arginine finger; other site 572547001720 UvrB/uvrC motif; Region: UVR; pfam02151 572547001721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572547001722 Walker A motif; other site 572547001723 ATP binding site [chemical binding]; other site 572547001724 Walker B motif; other site 572547001725 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 572547001726 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 572547001727 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 572547001728 active site 572547001729 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 572547001730 Mechanosensitive ion channel; Region: MS_channel; pfam00924 572547001731 S-layer homology domain; Region: SLH; pfam00395 572547001732 Sporulation related domain; Region: SPOR; pfam05036 572547001733 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 572547001734 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK04025 572547001735 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 572547001736 Na2 binding site [ion binding]; other site 572547001737 putative substrate binding site 1 [chemical binding]; other site 572547001738 Na binding site 1 [ion binding]; other site 572547001739 putative substrate binding site 2 [chemical binding]; other site 572547001740 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 572547001741 active site 572547001742 intersubunit interface [polypeptide binding]; other site 572547001743 zinc binding site [ion binding]; other site 572547001744 Na+ binding site [ion binding]; other site 572547001745 threonine synthase; Reviewed; Region: PRK06721 572547001746 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 572547001747 homodimer interface [polypeptide binding]; other site 572547001748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547001749 catalytic residue [active] 572547001750 homoserine kinase; Provisional; Region: PRK01212 572547001751 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 572547001752 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 572547001753 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 572547001754 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 572547001755 Walker A/P-loop; other site 572547001756 ATP binding site [chemical binding]; other site 572547001757 Q-loop/lid; other site 572547001758 ABC transporter signature motif; other site 572547001759 Walker B; other site 572547001760 D-loop; other site 572547001761 H-loop/switch region; other site 572547001762 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 572547001763 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 572547001764 nickel binding site [ion binding]; other site 572547001765 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 572547001766 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 572547001767 UGMP family protein; Validated; Region: PRK09604 572547001768 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 572547001769 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 572547001770 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 572547001771 oligomerisation interface [polypeptide binding]; other site 572547001772 mobile loop; other site 572547001773 roof hairpin; other site 572547001774 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 572547001775 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 572547001776 ring oligomerisation interface [polypeptide binding]; other site 572547001777 ATP/Mg binding site [chemical binding]; other site 572547001778 stacking interactions; other site 572547001779 hinge regions; other site 572547001780 GMP synthase; Reviewed; Region: guaA; PRK00074 572547001781 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 572547001782 AMP/PPi binding site [chemical binding]; other site 572547001783 candidate oxyanion hole; other site 572547001784 catalytic triad [active] 572547001785 potential glutamine specificity residues [chemical binding]; other site 572547001786 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 572547001787 ATP Binding subdomain [chemical binding]; other site 572547001788 Ligand Binding sites [chemical binding]; other site 572547001789 Dimerization subdomain; other site 572547001790 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 572547001791 Domain of unknown function DUF20; Region: UPF0118; pfam01594 572547001792 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572547001793 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494 572547001794 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 572547001795 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 572547001796 DNA primase; Validated; Region: dnaG; PRK05667 572547001797 CHC2 zinc finger; Region: zf-CHC2; pfam01807 572547001798 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 572547001799 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 572547001800 active site 572547001801 metal binding site [ion binding]; metal-binding site 572547001802 interdomain interaction site; other site 572547001803 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572547001804 RNA binding surface [nucleotide binding]; other site 572547001805 enolase; Provisional; Region: eno; PRK00077 572547001806 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 572547001807 dimer interface [polypeptide binding]; other site 572547001808 metal binding site [ion binding]; metal-binding site 572547001809 substrate binding pocket [chemical binding]; other site 572547001810 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 572547001811 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 572547001812 CoA binding domain; Region: CoA_binding; pfam02629 572547001813 Preprotein translocase subunit; Region: YajC; pfam02699 572547001814 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 572547001815 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 572547001816 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 572547001817 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 572547001818 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 572547001819 Protein export membrane protein; Region: SecD_SecF; pfam02355 572547001820 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 572547001821 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572547001822 FeS/SAM binding site; other site 572547001823 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 572547001824 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 572547001825 DHH family; Region: DHH; pfam01368 572547001826 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 572547001827 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572547001828 Zn2+ binding site [ion binding]; other site 572547001829 Mg2+ binding site [ion binding]; other site 572547001830 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 572547001831 synthetase active site [active] 572547001832 NTP binding site [chemical binding]; other site 572547001833 metal binding site [ion binding]; metal-binding site 572547001834 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 572547001835 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 572547001836 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 572547001837 dimerization interface [polypeptide binding]; other site 572547001838 putative tRNAtyr binding site [nucleotide binding]; other site 572547001839 putative active site [active] 572547001840 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 572547001841 hypothetical protein; Reviewed; Region: PRK00024 572547001842 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 572547001843 MPN+ (JAMM) motif; other site 572547001844 Zinc-binding site [ion binding]; other site 572547001845 rod shape-determining protein MreB; Provisional; Region: PRK13927 572547001846 MreB and similar proteins; Region: MreB_like; cd10225 572547001847 nucleotide binding site [chemical binding]; other site 572547001848 Mg binding site [ion binding]; other site 572547001849 putative protofilament interaction site [polypeptide binding]; other site 572547001850 RodZ interaction site [polypeptide binding]; other site 572547001851 rod shape-determining protein MreC; Provisional; Region: PRK13922 572547001852 rod shape-determining protein MreC; Region: MreC; pfam04085 572547001853 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 572547001854 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572547001855 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572547001856 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 572547001857 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 572547001858 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 572547001859 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 572547001860 Switch I; other site 572547001861 Switch II; other site 572547001862 Septum formation topological specificity factor MinE; Region: MinE; pfam03776 572547001863 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 572547001864 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 572547001865 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 572547001866 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572547001867 FeS/SAM binding site; other site 572547001868 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 572547001869 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 572547001870 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 572547001871 homodimer interface [polypeptide binding]; other site 572547001872 oligonucleotide binding site [chemical binding]; other site 572547001873 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 572547001874 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 572547001875 Walker A/P-loop; other site 572547001876 ATP binding site [chemical binding]; other site 572547001877 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 572547001878 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 572547001879 ABC transporter signature motif; other site 572547001880 Walker B; other site 572547001881 D-loop; other site 572547001882 H-loop/switch region; other site 572547001883 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572547001884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572547001885 S-adenosylmethionine binding site [chemical binding]; other site 572547001886 Predicted methyltransferases [General function prediction only]; Region: COG0313 572547001887 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 572547001888 putative SAM binding site [chemical binding]; other site 572547001889 putative homodimer interface [polypeptide binding]; other site 572547001890 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 572547001891 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 572547001892 active site 572547001893 HIGH motif; other site 572547001894 KMSKS motif; other site 572547001895 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 572547001896 tRNA binding surface [nucleotide binding]; other site 572547001897 anticodon binding site; other site 572547001898 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 572547001899 dimer interface [polypeptide binding]; other site 572547001900 putative tRNA-binding site [nucleotide binding]; other site 572547001901 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 572547001902 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 572547001903 active site 572547001904 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 572547001905 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 572547001906 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 572547001907 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 572547001908 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 572547001909 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 572547001910 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 572547001911 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 572547001912 RPB1 interaction site [polypeptide binding]; other site 572547001913 RPB10 interaction site [polypeptide binding]; other site 572547001914 RPB11 interaction site [polypeptide binding]; other site 572547001915 RPB3 interaction site [polypeptide binding]; other site 572547001916 RPB12 interaction site [polypeptide binding]; other site 572547001917 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 572547001918 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 572547001919 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 572547001920 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 572547001921 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 572547001922 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 572547001923 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 572547001924 G-loop; other site 572547001925 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 572547001926 DNA binding site [nucleotide binding] 572547001927 clamp; other site 572547001928 Rpb1 - Rpb2 interaction site [polypeptide binding]; other site 572547001929 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 572547001930 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 572547001931 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 572547001932 S17 interaction site [polypeptide binding]; other site 572547001933 S8 interaction site; other site 572547001934 16S rRNA interaction site [nucleotide binding]; other site 572547001935 streptomycin interaction site [chemical binding]; other site 572547001936 23S rRNA interaction site [nucleotide binding]; other site 572547001937 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 572547001938 30S ribosomal protein S7; Validated; Region: PRK05302 572547001939 elongation factor G; Reviewed; Region: PRK00007 572547001940 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 572547001941 G1 box; other site 572547001942 putative GEF interaction site [polypeptide binding]; other site 572547001943 GTP/Mg2+ binding site [chemical binding]; other site 572547001944 Switch I region; other site 572547001945 G2 box; other site 572547001946 G3 box; other site 572547001947 Switch II region; other site 572547001948 G4 box; other site 572547001949 G5 box; other site 572547001950 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 572547001951 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 572547001952 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 572547001953 elongation factor Tu; Reviewed; Region: PRK00049 572547001954 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 572547001955 G1 box; other site 572547001956 GEF interaction site [polypeptide binding]; other site 572547001957 GTP/Mg2+ binding site [chemical binding]; other site 572547001958 Switch I region; other site 572547001959 G2 box; other site 572547001960 G3 box; other site 572547001961 Switch II region; other site 572547001962 G4 box; other site 572547001963 G5 box; other site 572547001964 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 572547001965 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 572547001966 Antibiotic Binding Site [chemical binding]; other site 572547001967 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 572547001968 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 572547001969 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 572547001970 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 572547001971 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 572547001972 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 572547001973 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 572547001974 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 572547001975 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 572547001976 putative translocon binding site; other site 572547001977 protein-rRNA interface [nucleotide binding]; other site 572547001978 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 572547001979 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 572547001980 G-X-X-G motif; other site 572547001981 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 572547001982 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 572547001983 23S rRNA interface [nucleotide binding]; other site 572547001984 5S rRNA interface [nucleotide binding]; other site 572547001985 putative antibiotic binding site [chemical binding]; other site 572547001986 L25 interface [polypeptide binding]; other site 572547001987 L27 interface [polypeptide binding]; other site 572547001988 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 572547001989 23S rRNA interface [nucleotide binding]; other site 572547001990 putative translocon interaction site; other site 572547001991 signal recognition particle (SRP54) interaction site; other site 572547001992 L23 interface [polypeptide binding]; other site 572547001993 trigger factor interaction site; other site 572547001994 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 572547001995 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 572547001996 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 572547001997 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 572547001998 RNA binding site [nucleotide binding]; other site 572547001999 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 572547002000 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 572547002001 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 572547002002 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 572547002003 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 572547002004 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 572547002005 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 572547002006 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 572547002007 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 572547002008 5S rRNA interface [nucleotide binding]; other site 572547002009 L27 interface [polypeptide binding]; other site 572547002010 23S rRNA interface [nucleotide binding]; other site 572547002011 L5 interface [polypeptide binding]; other site 572547002012 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 572547002013 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 572547002014 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 572547002015 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 572547002016 23S rRNA binding site [nucleotide binding]; other site 572547002017 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 572547002018 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 572547002019 SecY translocase; Region: SecY; pfam00344 572547002020 adenylate kinase; Reviewed; Region: adk; PRK00279 572547002021 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 572547002022 AMP-binding site [chemical binding]; other site 572547002023 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 572547002024 methionine aminopeptidase; Provisional; Region: PRK08671 572547002025 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 572547002026 active site 572547002027 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 572547002028 RNA binding site [nucleotide binding]; other site 572547002029 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 572547002030 rRNA binding site [nucleotide binding]; other site 572547002031 predicted 30S ribosome binding site; other site 572547002032 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 572547002033 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 572547002034 30S ribosomal protein S13; Region: bact_S13; TIGR03631 572547002035 30S ribosomal protein S11; Validated; Region: PRK05309 572547002036 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 572547002037 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 572547002038 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572547002039 RNA binding surface [nucleotide binding]; other site 572547002040 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 572547002041 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 572547002042 alphaNTD homodimer interface [polypeptide binding]; other site 572547002043 alphaNTD - beta interaction site [polypeptide binding]; other site 572547002044 alphaNTD - beta' interaction site [polypeptide binding]; other site 572547002045 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 572547002046 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 572547002047 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 572547002048 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 572547002049 Walker A/P-loop; other site 572547002050 ATP binding site [chemical binding]; other site 572547002051 Q-loop/lid; other site 572547002052 ABC transporter signature motif; other site 572547002053 Walker B; other site 572547002054 D-loop; other site 572547002055 H-loop/switch region; other site 572547002056 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 572547002057 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 572547002058 Walker A/P-loop; other site 572547002059 ATP binding site [chemical binding]; other site 572547002060 Q-loop/lid; other site 572547002061 ABC transporter signature motif; other site 572547002062 Walker B; other site 572547002063 D-loop; other site 572547002064 H-loop/switch region; other site 572547002065 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 572547002066 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 572547002067 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 572547002068 dimerization interface 3.5A [polypeptide binding]; other site 572547002069 active site 572547002070 rod shape-determining protein MreB; Provisional; Region: PRK13927 572547002071 MreB and similar proteins; Region: MreB_like; cd10225 572547002072 nucleotide binding site [chemical binding]; other site 572547002073 Mg binding site [ion binding]; other site 572547002074 putative protofilament interaction site [polypeptide binding]; other site 572547002075 RodZ interaction site [polypeptide binding]; other site 572547002076 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 572547002077 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 572547002078 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 572547002079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572547002080 Coenzyme A binding pocket [chemical binding]; other site 572547002081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572547002082 comF family protein; Region: comF; TIGR00201 572547002083 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 572547002084 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 572547002085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572547002086 active site 572547002087 motif I; other site 572547002088 motif II; other site 572547002089 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 572547002090 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 572547002091 DRTGG domain; Region: DRTGG; pfam07085 572547002092 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 572547002093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 572547002094 ATP binding site [chemical binding]; other site 572547002095 G-X-G motif; other site 572547002096 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 572547002097 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572547002098 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 572547002099 Putative Fe-S cluster; Region: FeS; cl17515 572547002100 DRTGG domain; Region: DRTGG; pfam07085 572547002101 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 572547002102 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 572547002103 active site 572547002104 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 572547002105 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 572547002106 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 572547002107 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 572547002108 metal binding site [ion binding]; metal-binding site 572547002109 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 572547002110 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 572547002111 substrate binding site [chemical binding]; other site 572547002112 glutamase interaction surface [polypeptide binding]; other site 572547002113 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 572547002114 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 572547002115 catalytic residues [active] 572547002116 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 572547002117 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 572547002118 conserved cys residue [active] 572547002119 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cl00341 572547002120 4-fold oligomerization interface [polypeptide binding]; other site 572547002121 putative active site pocket [active] 572547002122 metal binding residues [ion binding]; metal-binding site 572547002123 3-fold/trimer interface [polypeptide binding]; other site 572547002124 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 572547002125 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 572547002126 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 572547002127 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 572547002128 dimer interface [polypeptide binding]; other site 572547002129 motif 1; other site 572547002130 active site 572547002131 motif 2; other site 572547002132 motif 3; other site 572547002133 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 572547002134 histidinol dehydrogenase; Region: hisD; TIGR00069 572547002135 NAD binding site [chemical binding]; other site 572547002136 dimerization interface [polypeptide binding]; other site 572547002137 product binding site; other site 572547002138 substrate binding site [chemical binding]; other site 572547002139 zinc binding site [ion binding]; other site 572547002140 catalytic residues [active] 572547002141 DNA repair protein RadA; Provisional; Region: PRK11823 572547002142 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572547002143 Walker A motif; other site 572547002144 ATP binding site [chemical binding]; other site 572547002145 Walker B motif; other site 572547002146 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 572547002147 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 572547002148 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 572547002149 dimer interface [polypeptide binding]; other site 572547002150 active site residues [active] 572547002151 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 572547002152 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 572547002153 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 572547002154 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 572547002155 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 572547002156 HIGH motif; other site 572547002157 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 572547002158 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572547002159 active site 572547002160 KMSKS motif; other site 572547002161 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 572547002162 tRNA binding surface [nucleotide binding]; other site 572547002163 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 572547002164 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 572547002165 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 572547002166 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 572547002167 putative Mg++ binding site [ion binding]; other site 572547002168 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 572547002169 Ribonuclease P; Region: Ribonuclease_P; pfam00825 572547002170 Haemolytic domain; Region: Haemolytic; pfam01809 572547002171 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 572547002172 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 572547002173 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 572547002174 G-X-X-G motif; other site 572547002175 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 572547002176 RxxxH motif; other site 572547002177 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 572547002178 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 572547002179 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 572547002180 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 572547002181 protein binding site [polypeptide binding]; other site 572547002182 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 572547002183 protein binding site [polypeptide binding]; other site 572547002184 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572547002185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572547002186 dimer interface [polypeptide binding]; other site 572547002187 phosphorylation site [posttranslational modification] 572547002188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572547002189 ATP binding site [chemical binding]; other site 572547002190 Mg2+ binding site [ion binding]; other site 572547002191 G-X-G motif; other site 572547002192 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572547002193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572547002194 active site 572547002195 phosphorylation site [posttranslational modification] 572547002196 intermolecular recognition site; other site 572547002197 dimerization interface [polypeptide binding]; other site 572547002198 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572547002199 DNA binding site [nucleotide binding] 572547002200 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 572547002201 16S/18S rRNA binding site [nucleotide binding]; other site 572547002202 S13e-L30e interaction site [polypeptide binding]; other site 572547002203 25S rRNA binding site [nucleotide binding]; other site 572547002204 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 572547002205 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 572547002206 RNase E interface [polypeptide binding]; other site 572547002207 trimer interface [polypeptide binding]; other site 572547002208 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 572547002209 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 572547002210 RNase E interface [polypeptide binding]; other site 572547002211 trimer interface [polypeptide binding]; other site 572547002212 active site 572547002213 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 572547002214 putative nucleic acid binding region [nucleotide binding]; other site 572547002215 G-X-X-G motif; other site 572547002216 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 572547002217 RNA binding site [nucleotide binding]; other site 572547002218 domain interface; other site 572547002219 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 572547002220 trimer interface [polypeptide binding]; other site 572547002221 active site 572547002222 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 572547002223 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 572547002224 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 572547002225 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 572547002226 active site 572547002227 dimer interface [polypeptide binding]; other site 572547002228 motif 1; other site 572547002229 motif 2; other site 572547002230 motif 3; other site 572547002231 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 572547002232 anticodon binding site; other site 572547002233 translation initiation factor IF-3; Region: infC; TIGR00168 572547002234 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 572547002235 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 572547002236 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 572547002237 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 572547002238 23S rRNA binding site [nucleotide binding]; other site 572547002239 L21 binding site [polypeptide binding]; other site 572547002240 L13 binding site [polypeptide binding]; other site 572547002241 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 572547002242 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 572547002243 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 572547002244 TrkA-N domain; Region: TrkA_N; pfam02254 572547002245 TrkA-C domain; Region: TrkA_C; pfam02080 572547002246 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 572547002247 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 572547002248 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 572547002249 dimer interface [polypeptide binding]; other site 572547002250 motif 1; other site 572547002251 active site 572547002252 motif 2; other site 572547002253 motif 3; other site 572547002254 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 572547002255 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 572547002256 putative tRNA-binding site [nucleotide binding]; other site 572547002257 B3/4 domain; Region: B3_4; pfam03483 572547002258 tRNA synthetase B5 domain; Region: B5; smart00874 572547002259 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 572547002260 dimer interface [polypeptide binding]; other site 572547002261 motif 1; other site 572547002262 motif 3; other site 572547002263 motif 2; other site 572547002264 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 572547002265 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 572547002266 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 572547002267 Colicin V production protein; Region: Colicin_V; pfam02674 572547002268 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 572547002269 MutS domain III; Region: MutS_III; pfam05192 572547002270 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 572547002271 Walker A/P-loop; other site 572547002272 ATP binding site [chemical binding]; other site 572547002273 Q-loop/lid; other site 572547002274 ABC transporter signature motif; other site 572547002275 Walker B; other site 572547002276 D-loop; other site 572547002277 H-loop/switch region; other site 572547002278 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 572547002279 Smr domain; Region: Smr; pfam01713 572547002280 glutamate formiminotransferase; Region: FtcD; TIGR02024 572547002281 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 572547002282 Formiminotransferase domain; Region: FTCD; pfam02971 572547002283 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 572547002284 Transcriptional regulator [Transcription]; Region: IclR; COG1414 572547002285 Bacterial transcriptional regulator; Region: IclR; pfam01614 572547002286 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 572547002287 Na binding site [ion binding]; other site 572547002288 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 572547002289 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 572547002290 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 572547002291 hexamer interface [polypeptide binding]; other site 572547002292 RNA binding site [nucleotide binding]; other site 572547002293 Histidine-zinc binding site [chemical binding]; other site 572547002294 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 572547002295 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 572547002296 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 572547002297 peptide chain release factor 1; Validated; Region: prfA; PRK00591 572547002298 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 572547002299 This domain is found in peptide chain release factors; Region: PCRF; smart00937 572547002300 RF-1 domain; Region: RF-1; pfam00472 572547002301 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 572547002302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572547002303 S-adenosylmethionine binding site [chemical binding]; other site 572547002304 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 572547002305 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572547002306 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572547002307 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 572547002308 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 572547002309 putative substrate binding site [chemical binding]; other site 572547002310 putative ATP binding site [chemical binding]; other site 572547002311 FOG: CBS domain [General function prediction only]; Region: COG0517 572547002312 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 572547002313 Peptidase family M48; Region: Peptidase_M48; cl12018 572547002314 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 572547002315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572547002316 Walker A motif; other site 572547002317 ATP binding site [chemical binding]; other site 572547002318 Walker B motif; other site 572547002319 arginine finger; other site 572547002320 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 572547002321 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 572547002322 active site 572547002323 PHP Thumb interface [polypeptide binding]; other site 572547002324 metal binding site [ion binding]; metal-binding site 572547002325 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 572547002326 generic binding surface I; other site 572547002327 generic binding surface II; other site 572547002328 pyruvate kinase; Provisional; Region: PRK06354 572547002329 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 572547002330 domain interfaces; other site 572547002331 active site 572547002332 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 572547002333 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 572547002334 putative active site [active] 572547002335 putative CoA binding site [chemical binding]; other site 572547002336 nudix motif; other site 572547002337 metal binding site [ion binding]; metal-binding site 572547002338 endonuclease IV; Provisional; Region: PRK01060 572547002339 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 572547002340 AP (apurinic/apyrimidinic) site pocket; other site 572547002341 DNA interaction; other site 572547002342 Metal-binding active site; metal-binding site 572547002343 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 572547002344 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 572547002345 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572547002346 catalytic residue [active] 572547002347 TIGR00159 family protein; Region: TIGR00159 572547002348 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 572547002349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 572547002350 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 572547002351 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 572547002352 active site 572547002353 substrate binding site [chemical binding]; other site 572547002354 metal binding site [ion binding]; metal-binding site 572547002355 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 572547002356 active site 572547002357 tetramer interface; other site 572547002358 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 572547002359 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 572547002360 glutaminase active site [active] 572547002361 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 572547002362 dimer interface [polypeptide binding]; other site 572547002363 active site 572547002364 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 572547002365 dimer interface [polypeptide binding]; other site 572547002366 active site 572547002367 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 572547002368 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572547002369 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 572547002370 active site 572547002371 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 572547002372 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 572547002373 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 572547002374 Substrate binding site; other site 572547002375 Mg++ binding site; other site 572547002376 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 572547002377 active site 572547002378 substrate binding site [chemical binding]; other site 572547002379 CoA binding site [chemical binding]; other site 572547002380 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 572547002381 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 572547002382 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572547002383 active site 572547002384 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 572547002385 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 572547002386 5S rRNA interface [nucleotide binding]; other site 572547002387 CTC domain interface [polypeptide binding]; other site 572547002388 L16 interface [polypeptide binding]; other site 572547002389 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 572547002390 putative active site [active] 572547002391 catalytic residue [active] 572547002392 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 572547002393 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 572547002394 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572547002395 ATP binding site [chemical binding]; other site 572547002396 putative Mg++ binding site [ion binding]; other site 572547002397 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572547002398 nucleotide binding region [chemical binding]; other site 572547002399 ATP-binding site [chemical binding]; other site 572547002400 TRCF domain; Region: TRCF; pfam03461 572547002401 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 572547002402 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 572547002403 homodimer interface [polypeptide binding]; other site 572547002404 metal binding site [ion binding]; metal-binding site 572547002405 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 572547002406 homodimer interface [polypeptide binding]; other site 572547002407 active site 572547002408 putative chemical substrate binding site [chemical binding]; other site 572547002409 metal binding site [ion binding]; metal-binding site 572547002410 oxaloacetate decarboxylase; Provisional; Region: PRK12331 572547002411 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 572547002412 active site 572547002413 catalytic residues [active] 572547002414 metal binding site [ion binding]; metal-binding site 572547002415 homodimer binding site [polypeptide binding]; other site 572547002416 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 572547002417 PhoH-like protein; Region: PhoH; pfam02562 572547002418 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 572547002419 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 572547002420 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572547002421 Zn2+ binding site [ion binding]; other site 572547002422 Mg2+ binding site [ion binding]; other site 572547002423 metal-binding heat shock protein; Provisional; Region: PRK00016 572547002424 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 572547002425 Domain of unknown function DUF21; Region: DUF21; pfam01595 572547002426 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 572547002427 Transporter associated domain; Region: CorC_HlyC; smart01091 572547002428 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 572547002429 active site 572547002430 catalytic motif [active] 572547002431 Zn binding site [ion binding]; other site 572547002432 GTPase Era; Reviewed; Region: era; PRK00089 572547002433 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 572547002434 G1 box; other site 572547002435 GTP/Mg2+ binding site [chemical binding]; other site 572547002436 Switch I region; other site 572547002437 G2 box; other site 572547002438 Switch II region; other site 572547002439 G3 box; other site 572547002440 G4 box; other site 572547002441 G5 box; other site 572547002442 Recombination protein O C terminal; Region: RecO_C; pfam02565 572547002443 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 572547002444 dimer interface [polypeptide binding]; other site 572547002445 motif 1; other site 572547002446 active site 572547002447 motif 2; other site 572547002448 motif 3; other site 572547002449 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 572547002450 DALR anticodon binding domain; Region: DALR_1; pfam05746 572547002451 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 572547002452 PEP synthetase regulatory protein; Provisional; Region: PRK05339 572547002453 pyruvate phosphate dikinase; Provisional; Region: PRK09279 572547002454 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 572547002455 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 572547002456 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 572547002457 phosphoenolpyruvate synthase; Validated; Region: PRK06464 572547002458 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 572547002459 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 572547002460 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 572547002461 Transglycosylase; Region: Transgly; pfam00912 572547002462 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 572547002463 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572547002464 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 572547002465 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572547002466 Walker A motif; other site 572547002467 ATP binding site [chemical binding]; other site 572547002468 Walker B motif; other site 572547002469 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 572547002470 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 572547002471 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 572547002472 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 572547002473 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 572547002474 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 572547002475 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 572547002476 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 572547002477 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 572547002478 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 572547002479 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572547002480 active site 572547002481 FtsH Extracellular; Region: FtsH_ext; pfam06480 572547002482 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 572547002483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572547002484 Walker B motif; other site 572547002485 arginine finger; other site 572547002486 Peptidase family M41; Region: Peptidase_M41; pfam01434 572547002487 excinuclease ABC subunit B; Provisional; Region: PRK05298 572547002488 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572547002489 ATP binding site [chemical binding]; other site 572547002490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572547002491 nucleotide binding region [chemical binding]; other site 572547002492 ATP-binding site [chemical binding]; other site 572547002493 Ultra-violet resistance protein B; Region: UvrB; pfam12344 572547002494 UvrB/uvrC motif; Region: UVR; pfam02151 572547002495 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 572547002496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572547002497 Walker A/P-loop; other site 572547002498 ATP binding site [chemical binding]; other site 572547002499 Q-loop/lid; other site 572547002500 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572547002501 ABC transporter signature motif; other site 572547002502 Walker B; other site 572547002503 D-loop; other site 572547002504 H-loop/switch region; other site 572547002505 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 572547002506 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 572547002507 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 572547002508 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 572547002509 pyrroline-5-carboxylate reductase; Region: PLN02688 572547002510 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 572547002511 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 572547002512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547002513 dimer interface [polypeptide binding]; other site 572547002514 conserved gate region; other site 572547002515 putative PBP binding loops; other site 572547002516 ABC-ATPase subunit interface; other site 572547002517 dipeptide transporter; Provisional; Region: PRK10913 572547002518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547002519 dimer interface [polypeptide binding]; other site 572547002520 conserved gate region; other site 572547002521 putative PBP binding loops; other site 572547002522 ABC-ATPase subunit interface; other site 572547002523 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 572547002524 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572547002525 Walker A/P-loop; other site 572547002526 ATP binding site [chemical binding]; other site 572547002527 Q-loop/lid; other site 572547002528 ABC transporter signature motif; other site 572547002529 Walker B; other site 572547002530 D-loop; other site 572547002531 H-loop/switch region; other site 572547002532 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 572547002533 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 572547002534 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572547002535 Walker A/P-loop; other site 572547002536 ATP binding site [chemical binding]; other site 572547002537 Q-loop/lid; other site 572547002538 ABC transporter signature motif; other site 572547002539 Walker B; other site 572547002540 D-loop; other site 572547002541 H-loop/switch region; other site 572547002542 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 572547002543 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 572547002544 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 572547002545 Beta-lactamase; Region: Beta-lactamase; pfam00144 572547002546 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572547002547 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 572547002548 putative carbohydrate kinase; Provisional; Region: PRK10565 572547002549 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 572547002550 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 572547002551 putative substrate binding site [chemical binding]; other site 572547002552 putative ATP binding site [chemical binding]; other site 572547002553 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 572547002554 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 572547002555 Glycoprotease family; Region: Peptidase_M22; pfam00814 572547002556 Ferredoxin [Energy production and conversion]; Region: COG1146 572547002557 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 572547002558 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 572547002559 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 572547002560 dimer interface [polypeptide binding]; other site 572547002561 PYR/PP interface [polypeptide binding]; other site 572547002562 TPP binding site [chemical binding]; other site 572547002563 substrate binding site [chemical binding]; other site 572547002564 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572547002565 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 572547002566 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 572547002567 TPP-binding site [chemical binding]; other site 572547002568 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 572547002569 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 572547002570 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 572547002571 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 572547002572 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 572547002573 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 572547002574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572547002575 S-adenosylmethionine binding site [chemical binding]; other site 572547002576 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 572547002577 V-type ATP synthase subunit I; Validated; Region: PRK05771 572547002578 V-type ATP synthase subunit K; Validated; Region: PRK06558 572547002579 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 572547002580 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 572547002581 ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991 572547002582 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 572547002583 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 572547002584 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 572547002585 V-type ATP synthase subunit A; Provisional; Region: PRK04192 572547002586 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 572547002587 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 572547002588 Walker A motif/ATP binding site; other site 572547002589 Walker B motif; other site 572547002590 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 572547002591 V-type ATP synthase subunit B; Provisional; Region: PRK04196 572547002592 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 572547002593 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 572547002594 Walker A motif homologous position; other site 572547002595 Walker B motif; other site 572547002596 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 572547002597 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 572547002598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 572547002599 MraZ protein; Region: MraZ; pfam02381 572547002600 MraZ protein; Region: MraZ; pfam02381 572547002601 MraW methylase family; Region: Methyltransf_5; cl17771 572547002602 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 572547002603 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 572547002604 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572547002605 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572547002606 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 572547002607 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 572547002608 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572547002609 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572547002610 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 572547002611 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 572547002612 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572547002613 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572547002614 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 572547002615 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 572547002616 Mg++ binding site [ion binding]; other site 572547002617 putative catalytic motif [active] 572547002618 putative substrate binding site [chemical binding]; other site 572547002619 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 572547002620 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 572547002621 NAD binding site [chemical binding]; other site 572547002622 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572547002623 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572547002624 cell division protein FtsW; Region: ftsW; TIGR02614 572547002625 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 572547002626 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 572547002627 active site 572547002628 homodimer interface [polypeptide binding]; other site 572547002629 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 572547002630 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572547002631 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572547002632 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 572547002633 FAD binding domain; Region: FAD_binding_4; pfam01565 572547002634 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 572547002635 cell division protein FtsA; Region: ftsA; TIGR01174 572547002636 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 572547002637 nucleotide binding site [chemical binding]; other site 572547002638 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 572547002639 Cell division protein FtsA; Region: FtsA; pfam14450 572547002640 cell division protein FtsZ; Validated; Region: PRK09330 572547002641 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 572547002642 nucleotide binding site [chemical binding]; other site 572547002643 SulA interaction site; other site 572547002644 Sporulation related domain; Region: SPOR; pfam05036 572547002645 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 572547002646 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 572547002647 dimer interface [polypeptide binding]; other site 572547002648 putative functional site; other site 572547002649 putative MPT binding site; other site 572547002650 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 572547002651 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 572547002652 dimer interface [polypeptide binding]; other site 572547002653 putative functional site; other site 572547002654 putative MPT binding site; other site 572547002655 PBP superfamily domain; Region: PBP_like; pfam12727 572547002656 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 572547002657 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572547002658 FeS/SAM binding site; other site 572547002659 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 572547002660 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 572547002661 trimer interface [polypeptide binding]; other site 572547002662 dimer interface [polypeptide binding]; other site 572547002663 putative active site [active] 572547002664 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 572547002665 MPT binding site; other site 572547002666 trimer interface [polypeptide binding]; other site 572547002667 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 572547002668 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 572547002669 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 572547002670 phosphate binding site [ion binding]; other site 572547002671 putative substrate binding pocket [chemical binding]; other site 572547002672 dimer interface [polypeptide binding]; other site 572547002673 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 572547002674 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 572547002675 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 572547002676 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 572547002677 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 572547002678 Phosphoglycerate kinase; Region: PGK; pfam00162 572547002679 substrate binding site [chemical binding]; other site 572547002680 hinge regions; other site 572547002681 ADP binding site [chemical binding]; other site 572547002682 catalytic site [active] 572547002683 triosephosphate isomerase; Provisional; Region: PRK14567 572547002684 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 572547002685 substrate binding site [chemical binding]; other site 572547002686 dimer interface [polypeptide binding]; other site 572547002687 catalytic triad [active] 572547002688 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 572547002689 Oligomerisation domain; Region: Oligomerisation; pfam02410 572547002690 Transcriptional regulator [Transcription]; Region: LytR; COG1316 572547002691 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 572547002692 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 572547002693 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 572547002694 active site 572547002695 (T/H)XGH motif; other site 572547002696 GTPase CgtA; Reviewed; Region: obgE; PRK12297 572547002697 GTP1/OBG; Region: GTP1_OBG; pfam01018 572547002698 Obg GTPase; Region: Obg; cd01898 572547002699 G1 box; other site 572547002700 GTP/Mg2+ binding site [chemical binding]; other site 572547002701 Switch I region; other site 572547002702 G2 box; other site 572547002703 G3 box; other site 572547002704 Switch II region; other site 572547002705 G4 box; other site 572547002706 G5 box; other site 572547002707 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 572547002708 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 572547002709 Protein of unknown function (DUF464); Region: DUF464; pfam04327 572547002710 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 572547002711 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 572547002712 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 572547002713 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 572547002714 Walker A/P-loop; other site 572547002715 ATP binding site [chemical binding]; other site 572547002716 Q-loop/lid; other site 572547002717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572547002718 ABC transporter signature motif; other site 572547002719 Walker B; other site 572547002720 D-loop; other site 572547002721 H-loop/switch region; other site 572547002722 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 572547002723 ATP-NAD kinase; Region: NAD_kinase; pfam01513 572547002724 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 572547002725 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572547002726 RNA binding surface [nucleotide binding]; other site 572547002727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572547002728 S-adenosylmethionine binding site [chemical binding]; other site 572547002729 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 572547002730 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 572547002731 TPP-binding site; other site 572547002732 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 572547002733 PYR/PP interface [polypeptide binding]; other site 572547002734 dimer interface [polypeptide binding]; other site 572547002735 TPP binding site [chemical binding]; other site 572547002736 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572547002737 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 572547002738 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 572547002739 substrate binding pocket [chemical binding]; other site 572547002740 chain length determination region; other site 572547002741 substrate-Mg2+ binding site; other site 572547002742 catalytic residues [active] 572547002743 aspartate-rich region 1; other site 572547002744 active site lid residues [active] 572547002745 aspartate-rich region 2; other site 572547002746 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 572547002747 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 572547002748 Thiamine pyrophosphokinase; Region: TPK; cd07995 572547002749 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 572547002750 active site 572547002751 dimerization interface [polypeptide binding]; other site 572547002752 thiamine binding site [chemical binding]; other site 572547002753 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 572547002754 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572547002755 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 572547002756 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 572547002757 YceG-like family; Region: YceG; pfam02618 572547002758 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 572547002759 dimerization interface [polypeptide binding]; other site 572547002760 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 572547002761 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572547002762 FeS/SAM binding site; other site 572547002763 hypothetical protein; Provisional; Region: PRK03881 572547002764 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 572547002765 AMMECR1; Region: AMMECR1; pfam01871 572547002766 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 572547002767 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 572547002768 Stage II sporulation protein; Region: SpoIID; pfam08486 572547002769 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 572547002770 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 572547002771 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 572547002772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572547002773 Walker A motif; other site 572547002774 ATP binding site [chemical binding]; other site 572547002775 Walker B motif; other site 572547002776 arginine finger; other site 572547002777 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 572547002778 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 572547002779 RuvA N terminal domain; Region: RuvA_N; pfam01330 572547002780 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 572547002781 active site 572547002782 putative DNA-binding cleft [nucleotide binding]; other site 572547002783 dimer interface [polypeptide binding]; other site 572547002784 hypothetical protein; Validated; Region: PRK00110 572547002785 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 572547002786 NAD synthetase; Provisional; Region: PRK13980 572547002787 homodimer interface [polypeptide binding]; other site 572547002788 NAD binding pocket [chemical binding]; other site 572547002789 ATP binding pocket [chemical binding]; other site 572547002790 Mg binding site [ion binding]; other site 572547002791 active-site loop [active] 572547002792 nickel responsive regulator; Provisional; Region: PRK04460 572547002793 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 572547002794 ornithine carbamoyltransferase; Validated; Region: PRK02102 572547002795 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 572547002796 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 572547002797 GcpE protein; Region: GcpE; pfam04551 572547002798 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 572547002799 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 572547002800 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 572547002801 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 572547002802 active site 572547002803 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 572547002804 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 572547002805 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 572547002806 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 572547002807 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 572547002808 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 572547002809 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 572547002810 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 572547002811 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 572547002812 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 572547002813 catalytic residue [active] 572547002814 putative FPP diphosphate binding site; other site 572547002815 putative FPP binding hydrophobic cleft; other site 572547002816 dimer interface [polypeptide binding]; other site 572547002817 putative IPP diphosphate binding site; other site 572547002818 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 572547002819 Fe-S cluster binding site [ion binding]; other site 572547002820 active site 572547002821 Asp23 family; Region: Asp23; cl00574 572547002822 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 572547002823 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 572547002824 hinge; other site 572547002825 active site 572547002826 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 572547002827 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 572547002828 active site 572547002829 homodimer interface [polypeptide binding]; other site 572547002830 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 572547002831 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 572547002832 Mg++ binding site [ion binding]; other site 572547002833 putative catalytic motif [active] 572547002834 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 572547002835 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572547002836 active site 572547002837 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 572547002838 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 572547002839 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 572547002840 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 572547002841 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 572547002842 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 572547002843 Walker A; other site 572547002844 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 572547002845 B12 binding site [chemical binding]; other site 572547002846 cobalt ligand [ion binding]; other site 572547002847 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 572547002848 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 572547002849 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 572547002850 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 572547002851 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 572547002852 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572547002853 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572547002854 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 572547002855 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 572547002856 HIGH motif; other site 572547002857 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 572547002858 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 572547002859 active site 572547002860 KMSKS motif; other site 572547002861 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 572547002862 tRNA binding surface [nucleotide binding]; other site 572547002863 anticodon binding site; other site 572547002864 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 572547002865 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 572547002866 G1 box; other site 572547002867 GTP/Mg2+ binding site [chemical binding]; other site 572547002868 Switch I region; other site 572547002869 G2 box; other site 572547002870 G3 box; other site 572547002871 Switch II region; other site 572547002872 G4 box; other site 572547002873 G5 box; other site 572547002874 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 572547002875 Found in ATP-dependent protease La (LON); Region: LON; smart00464 572547002876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572547002877 Walker A motif; other site 572547002878 ATP binding site [chemical binding]; other site 572547002879 Walker B motif; other site 572547002880 arginine finger; other site 572547002881 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 572547002882 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 572547002883 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 572547002884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572547002885 Walker A motif; other site 572547002886 ATP binding site [chemical binding]; other site 572547002887 Walker B motif; other site 572547002888 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 572547002889 Clp protease; Region: CLP_protease; pfam00574 572547002890 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 572547002891 oligomer interface [polypeptide binding]; other site 572547002892 active site residues [active] 572547002893 trigger factor; Region: tig; TIGR00115 572547002894 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 572547002895 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 572547002896 DNA-binding site [nucleotide binding]; DNA binding site 572547002897 RNA-binding motif; other site 572547002898 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 572547002899 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572547002900 active site 572547002901 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 572547002902 Ligand binding site; other site 572547002903 metal-binding site 572547002904 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 572547002905 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 572547002906 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 572547002907 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 572547002908 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 572547002909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572547002910 Walker A/P-loop; other site 572547002911 ATP binding site [chemical binding]; other site 572547002912 Q-loop/lid; other site 572547002913 ABC transporter signature motif; other site 572547002914 Walker B; other site 572547002915 D-loop; other site 572547002916 H-loop/switch region; other site 572547002917 TOBE domain; Region: TOBE_2; pfam08402 572547002918 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 572547002919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547002920 dimer interface [polypeptide binding]; other site 572547002921 conserved gate region; other site 572547002922 putative PBP binding loops; other site 572547002923 ABC-ATPase subunit interface; other site 572547002924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547002925 dimer interface [polypeptide binding]; other site 572547002926 conserved gate region; other site 572547002927 putative PBP binding loops; other site 572547002928 ABC-ATPase subunit interface; other site 572547002929 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 572547002930 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 572547002931 Minimal MMP-like domain found in Thermus thermophilus hypothetical protein TTHA0227 and similar proteins; Region: MMP_TTHA0227; cd12953 572547002932 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 572547002933 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 572547002934 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 572547002935 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 572547002936 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 572547002937 substrate binding site [chemical binding]; other site 572547002938 Predicted aconitase [General function prediction only]; Region: COG1679 572547002939 Protein of unknown function (DUF521); Region: DUF521; pfam04412 572547002940 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 572547002941 DctM-like transporters; Region: DctM; pfam06808 572547002942 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 572547002943 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 572547002944 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 572547002945 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 572547002946 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 572547002947 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 572547002948 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 572547002949 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 572547002950 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 572547002951 putative active site [active] 572547002952 Predicted transcriptional regulator [Transcription]; Region: COG2378 572547002953 WYL domain; Region: WYL; pfam13280 572547002954 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 572547002955 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 572547002956 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 572547002957 DctM-like transporters; Region: DctM; pfam06808 572547002958 PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992 572547002959 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 572547002960 phosphate binding site [ion binding]; other site 572547002961 KTSC domain; Region: KTSC; pfam13619 572547002962 Domain of unknown function DUF87; Region: DUF87; pfam01935 572547002963 AAA-like domain; Region: AAA_10; pfam12846 572547002964 SIR2-like domain; Region: SIR2_2; pfam13289 572547002965 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 572547002966 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 572547002967 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 572547002968 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 572547002969 putative active site [active] 572547002970 catalytic site [active] 572547002971 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 572547002972 putative active site [active] 572547002973 catalytic site [active] 572547002974 phosphodiesterase YaeI; Provisional; Region: PRK11340 572547002975 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 572547002976 putative active site [active] 572547002977 putative metal binding site [ion binding]; other site 572547002978 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 572547002979 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572547002980 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572547002981 non-specific DNA binding site [nucleotide binding]; other site 572547002982 sequence-specific DNA binding site [nucleotide binding]; other site 572547002983 salt bridge; other site 572547002984 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 572547002985 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572547002986 active site 572547002987 DNA binding site [nucleotide binding] 572547002988 Int/Topo IB signature motif; other site 572547002989 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 572547002990 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572547002991 Walker A motif; other site 572547002992 ATP binding site [chemical binding]; other site 572547002993 Walker B motif; other site 572547002994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572547002995 salt bridge; other site 572547002996 non-specific DNA binding site [nucleotide binding]; other site 572547002997 sequence-specific DNA binding site [nucleotide binding]; other site 572547002998 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 572547002999 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 572547003000 active site 572547003001 Predicted integral membrane protein [Function unknown]; Region: COG5505 572547003002 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 572547003003 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 572547003004 Domain of unknown function (DUF814); Region: DUF814; pfam05670 572547003005 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 572547003006 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572547003007 RNA binding surface [nucleotide binding]; other site 572547003008 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 572547003009 active site 572547003010 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 572547003011 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572547003012 active site 572547003013 HIGH motif; other site 572547003014 nucleotide binding site [chemical binding]; other site 572547003015 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 572547003016 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 572547003017 active site 572547003018 KMSKS motif; other site 572547003019 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 572547003020 tRNA binding surface [nucleotide binding]; other site 572547003021 anticodon binding site; other site 572547003022 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 572547003023 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 572547003024 DctM-like transporters; Region: DctM; pfam06808 572547003025 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 572547003026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572547003027 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 572547003028 non-specific DNA binding site [nucleotide binding]; other site 572547003029 salt bridge; other site 572547003030 sequence-specific DNA binding site [nucleotide binding]; other site 572547003031 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 572547003032 Catalytic site [active] 572547003033 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 572547003034 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 572547003035 active site 572547003036 DNA binding site [nucleotide binding] 572547003037 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 572547003038 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 572547003039 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 572547003040 active site 572547003041 Riboflavin kinase; Region: Flavokinase; pfam01687 572547003042 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 572547003043 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 572547003044 active site 572547003045 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 572547003046 DHH family; Region: DHH; pfam01368 572547003047 DHHA1 domain; Region: DHHA1; pfam02272 572547003048 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 572547003049 Protein of unknown function (DUF503); Region: DUF503; cl00669 572547003050 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 572547003051 translation initiation factor IF-2; Region: IF-2; TIGR00487 572547003052 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 572547003053 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 572547003054 G1 box; other site 572547003055 putative GEF interaction site [polypeptide binding]; other site 572547003056 GTP/Mg2+ binding site [chemical binding]; other site 572547003057 Switch I region; other site 572547003058 G2 box; other site 572547003059 G3 box; other site 572547003060 Switch II region; other site 572547003061 G4 box; other site 572547003062 G5 box; other site 572547003063 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 572547003064 Translation-initiation factor 2; Region: IF-2; pfam11987 572547003065 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 572547003066 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 572547003067 putative RNA binding cleft [nucleotide binding]; other site 572547003068 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 572547003069 NusA N-terminal domain; Region: NusA_N; pfam08529 572547003070 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 572547003071 RNA binding site [nucleotide binding]; other site 572547003072 homodimer interface [polypeptide binding]; other site 572547003073 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 572547003074 G-X-X-G motif; other site 572547003075 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 572547003076 G-X-X-G motif; other site 572547003077 ribosome maturation protein RimP; Reviewed; Region: PRK00092 572547003078 Sm and related proteins; Region: Sm_like; cl00259 572547003079 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 572547003080 putative oligomer interface [polypeptide binding]; other site 572547003081 putative RNA binding site [nucleotide binding]; other site 572547003082 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 572547003083 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 572547003084 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 572547003085 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 572547003086 active site 572547003087 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 572547003088 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 572547003089 HIGH motif; other site 572547003090 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 572547003091 active site 572547003092 KMSKS motif; other site 572547003093 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 572547003094 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 572547003095 substrate binding site; other site 572547003096 dimer interface; other site 572547003097 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 572547003098 homotrimer interaction site [polypeptide binding]; other site 572547003099 zinc binding site [ion binding]; other site 572547003100 CDP-binding sites; other site 572547003101 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 572547003102 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 572547003103 putative active site [active] 572547003104 recombination protein RecR; Reviewed; Region: recR; PRK00076 572547003105 RecR protein; Region: RecR; pfam02132 572547003106 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 572547003107 putative active site [active] 572547003108 putative metal-binding site [ion binding]; other site 572547003109 tetramer interface [polypeptide binding]; other site 572547003110 hypothetical protein; Validated; Region: PRK00153 572547003111 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 572547003112 ATP synthase subunit D; Region: ATP-synt_D; cl00613 572547003113 V-type ATP synthase subunit B; Provisional; Region: PRK04196 572547003114 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 572547003115 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 572547003116 Walker A motif homologous position; other site 572547003117 Walker B motif; other site 572547003118 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 572547003119 V-type ATP synthase subunit A; Provisional; Region: PRK04192 572547003120 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 572547003121 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 572547003122 Walker A motif/ATP binding site; other site 572547003123 Walker B motif; other site 572547003124 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 572547003125 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 572547003126 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 572547003127 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 572547003128 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 572547003129 V-type ATP synthase subunit I; Validated; Region: PRK05771 572547003130 FOG: CBS domain [General function prediction only]; Region: COG0517 572547003131 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 572547003132 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 572547003133 Mg++ binding site [ion binding]; other site 572547003134 putative catalytic motif [active] 572547003135 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 572547003136 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 572547003137 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 572547003138 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 572547003139 metal binding site [ion binding]; metal-binding site 572547003140 dimer interface [polypeptide binding]; other site 572547003141 seryl-tRNA synthetase; Provisional; Region: PRK05431 572547003142 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 572547003143 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 572547003144 dimer interface [polypeptide binding]; other site 572547003145 active site 572547003146 motif 1; other site 572547003147 motif 2; other site 572547003148 motif 3; other site 572547003149 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 572547003150 homopentamer interface [polypeptide binding]; other site 572547003151 active site 572547003152 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 572547003153 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 572547003154 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 572547003155 dimerization interface [polypeptide binding]; other site 572547003156 active site 572547003157 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 572547003158 Lumazine binding domain; Region: Lum_binding; pfam00677 572547003159 Lumazine binding domain; Region: Lum_binding; pfam00677 572547003160 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 572547003161 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 572547003162 catalytic motif [active] 572547003163 Zn binding site [ion binding]; other site 572547003164 RibD C-terminal domain; Region: RibD_C; cl17279 572547003165 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 572547003166 GIY-YIG motif/motif A; other site 572547003167 active site 572547003168 catalytic site [active] 572547003169 putative DNA binding site [nucleotide binding]; other site 572547003170 metal binding site [ion binding]; metal-binding site 572547003171 UvrB/uvrC motif; Region: UVR; pfam02151 572547003172 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 572547003173 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 572547003174 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 572547003175 active site 572547003176 HIGH motif; other site 572547003177 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 572547003178 KMSKS motif; other site 572547003179 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 572547003180 tRNA binding surface [nucleotide binding]; other site 572547003181 anticodon binding site; other site 572547003182 QueT transporter; Region: QueT; pfam06177 572547003183 allantoate amidohydrolase; Reviewed; Region: PRK09290 572547003184 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 572547003185 active site 572547003186 metal binding site [ion binding]; metal-binding site 572547003187 dimer interface [polypeptide binding]; other site 572547003188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572547003189 S-adenosylmethionine binding site [chemical binding]; other site 572547003190 Rubrerythrin [Energy production and conversion]; Region: COG1592 572547003191 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 572547003192 binuclear metal center [ion binding]; other site 572547003193 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 572547003194 iron binding site [ion binding]; other site 572547003195 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 572547003196 putative rRNA binding site [nucleotide binding]; other site 572547003197 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 572547003198 nudix motif; other site 572547003199 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572547003200 Peptidase family M23; Region: Peptidase_M23; pfam01551 572547003201 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 572547003202 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 572547003203 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 572547003204 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 572547003205 purine nucleoside phosphorylase; Provisional; Region: PRK08202 572547003206 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 572547003207 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572547003208 active site 572547003209 DNA binding site [nucleotide binding] 572547003210 Int/Topo IB signature motif; other site 572547003211 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 572547003212 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 572547003213 dimer interface [polypeptide binding]; other site 572547003214 ADP-ribose binding site [chemical binding]; other site 572547003215 active site 572547003216 nudix motif; other site 572547003217 metal binding site [ion binding]; metal-binding site 572547003218 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 572547003219 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 572547003220 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 572547003221 TPP-binding site [chemical binding]; other site 572547003222 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 572547003223 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 572547003224 dimer interface [polypeptide binding]; other site 572547003225 PYR/PP interface [polypeptide binding]; other site 572547003226 TPP binding site [chemical binding]; other site 572547003227 substrate binding site [chemical binding]; other site 572547003228 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 572547003229 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572547003230 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572547003231 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 572547003232 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 572547003233 putative active site [active] 572547003234 substrate binding site [chemical binding]; other site 572547003235 putative cosubstrate binding site; other site 572547003236 catalytic site [active] 572547003237 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 572547003238 substrate binding site [chemical binding]; other site 572547003239 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 572547003240 active site 572547003241 catalytic residues [active] 572547003242 metal binding site [ion binding]; metal-binding site 572547003243 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 572547003244 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 572547003245 RNA binding site [nucleotide binding]; other site 572547003246 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 572547003247 RNA binding site [nucleotide binding]; other site 572547003248 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 572547003249 RNA binding site [nucleotide binding]; other site 572547003250 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 572547003251 RNA binding site [nucleotide binding]; other site 572547003252 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 572547003253 RNA binding site [nucleotide binding]; other site 572547003254 domain interface; other site 572547003255 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 572547003256 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 572547003257 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 572547003258 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 572547003259 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 572547003260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 572547003261 Mg2+ binding site [ion binding]; other site 572547003262 G-X-G motif; other site 572547003263 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 572547003264 ATP binding site [chemical binding]; other site 572547003265 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 572547003266 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 572547003267 MutS domain I; Region: MutS_I; pfam01624 572547003268 MutS domain II; Region: MutS_II; pfam05188 572547003269 MutS domain III; Region: MutS_III; pfam05192 572547003270 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 572547003271 Walker A/P-loop; other site 572547003272 ATP binding site [chemical binding]; other site 572547003273 Q-loop/lid; other site 572547003274 ABC transporter signature motif; other site 572547003275 Walker B; other site 572547003276 D-loop; other site 572547003277 H-loop/switch region; other site 572547003278 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 572547003279 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 572547003280 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 572547003281 motif 1; other site 572547003282 active site 572547003283 motif 2; other site 572547003284 motif 3; other site 572547003285 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 572547003286 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 572547003287 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 572547003288 active site 572547003289 putative substrate binding pocket [chemical binding]; other site 572547003290 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 572547003291 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 572547003292 homotetramer interface [polypeptide binding]; other site 572547003293 ligand binding site [chemical binding]; other site 572547003294 catalytic site [active] 572547003295 NAD binding site [chemical binding]; other site 572547003296 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 572547003297 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 572547003298 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 572547003299 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 572547003300 generic binding surface II; other site 572547003301 generic binding surface I; other site 572547003302 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 572547003303 putative RNA binding site [nucleotide binding]; other site 572547003304 Asp23 family; Region: Asp23; pfam03780 572547003305 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 572547003306 elongation factor P; Validated; Region: PRK00529 572547003307 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 572547003308 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 572547003309 RNA binding site [nucleotide binding]; other site 572547003310 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 572547003311 RNA binding site [nucleotide binding]; other site 572547003312 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 572547003313 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572547003314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547003315 homodimer interface [polypeptide binding]; other site 572547003316 catalytic residue [active] 572547003317 Trp repressor protein; Region: Trp_repressor; cl17266 572547003318 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 572547003319 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 572547003320 minor groove reading motif; other site 572547003321 helix-hairpin-helix signature motif; other site 572547003322 substrate binding pocket [chemical binding]; other site 572547003323 active site 572547003324 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 572547003325 AAA domain; Region: AAA_32; pfam13654 572547003326 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 572547003327 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 572547003328 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 572547003329 Ligand Binding Site [chemical binding]; other site 572547003330 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 572547003331 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 572547003332 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572547003333 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 572547003334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572547003335 motif II; other site 572547003336 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 572547003337 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 572547003338 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 572547003339 Walker A motif; other site 572547003340 homodimer interface [polypeptide binding]; other site 572547003341 ATP binding site [chemical binding]; other site 572547003342 hydroxycobalamin binding site [chemical binding]; other site 572547003343 Walker B motif; other site 572547003344 Acylphosphatase; Region: Acylphosphatase; pfam00708 572547003345 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 572547003346 HypF finger; Region: zf-HYPF; pfam07503 572547003347 HypF finger; Region: zf-HYPF; pfam07503 572547003348 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 572547003349 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 572547003350 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 572547003351 putative active site [active] 572547003352 adenylosuccinate lyase; Provisional; Region: PRK07492 572547003353 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 572547003354 tetramer interface [polypeptide binding]; other site 572547003355 active site 572547003356 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 572547003357 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 572547003358 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 572547003359 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 572547003360 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 572547003361 P loop; other site 572547003362 GTP binding site [chemical binding]; other site 572547003363 PSP1 C-terminal conserved region; Region: PSP1; cl00770 572547003364 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 572547003365 DNA polymerase III subunit delta'; Validated; Region: PRK08485 572547003366 thymidylate kinase; Validated; Region: tmk; PRK00698 572547003367 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 572547003368 TMP-binding site; other site 572547003369 ATP-binding site [chemical binding]; other site 572547003370 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 572547003371 peptide chain release factor 2; Validated; Region: prfB; PRK00578 572547003372 PCRF domain; Region: PCRF; pfam03462 572547003373 RF-1 domain; Region: RF-1; pfam00472 572547003374 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 572547003375 dimerization interface [polypeptide binding]; other site 572547003376 putative ATP binding site [chemical binding]; other site 572547003377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572547003378 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572547003379 putative substrate translocation pore; other site 572547003380 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 572547003381 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 572547003382 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572547003383 active site 572547003384 ribonuclease III; Reviewed; Region: rnc; PRK00102 572547003385 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 572547003386 dimerization interface [polypeptide binding]; other site 572547003387 active site 572547003388 metal binding site [ion binding]; metal-binding site 572547003389 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 572547003390 dsRNA binding site [nucleotide binding]; other site 572547003391 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 572547003392 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 572547003393 dimer interface [polypeptide binding]; other site 572547003394 active site 572547003395 acyl carrier protein; Provisional; Region: acpP; PRK00982 572547003396 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 572547003397 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 572547003398 NAD(P) binding site [chemical binding]; other site 572547003399 homotetramer interface [polypeptide binding]; other site 572547003400 homodimer interface [polypeptide binding]; other site 572547003401 active site 572547003402 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 572547003403 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 572547003404 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 572547003405 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 572547003406 FMN binding site [chemical binding]; other site 572547003407 substrate binding site [chemical binding]; other site 572547003408 putative catalytic residue [active] 572547003409 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 572547003410 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 572547003411 dimer interface [polypeptide binding]; other site 572547003412 active site 572547003413 CoA binding pocket [chemical binding]; other site 572547003414 putative phosphate acyltransferase; Provisional; Region: PRK05331 572547003415 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 572547003416 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 572547003417 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 572547003418 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 572547003419 propionate/acetate kinase; Provisional; Region: PRK12379 572547003420 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 572547003421 hypothetical protein; Provisional; Region: PRK13670 572547003422 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 572547003423 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 572547003424 active site 572547003425 (T/H)XGH motif; other site 572547003426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572547003427 S-adenosylmethionine binding site [chemical binding]; other site 572547003428 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 572547003429 homodimer interaction site [polypeptide binding]; other site 572547003430 cofactor binding site; other site 572547003431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572547003432 S-adenosylmethionine binding site [chemical binding]; other site 572547003433 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 572547003434 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 572547003435 dimer interface [polypeptide binding]; other site 572547003436 PYR/PP interface [polypeptide binding]; other site 572547003437 TPP binding site [chemical binding]; other site 572547003438 substrate binding site [chemical binding]; other site 572547003439 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 572547003440 Domain of unknown function; Region: EKR; smart00890 572547003441 4Fe-4S binding domain; Region: Fer4_6; pfam12837 572547003442 4Fe-4S binding domain; Region: Fer4; pfam00037 572547003443 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 572547003444 TPP-binding site [chemical binding]; other site 572547003445 dimer interface [polypeptide binding]; other site 572547003446 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 572547003447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572547003448 S-adenosylmethionine binding site [chemical binding]; other site 572547003449 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 572547003450 IHF dimer interface [polypeptide binding]; other site 572547003451 IHF - DNA interface [nucleotide binding]; other site 572547003452 GTP-binding protein Der; Reviewed; Region: PRK00093 572547003453 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 572547003454 G1 box; other site 572547003455 GTP/Mg2+ binding site [chemical binding]; other site 572547003456 Switch I region; other site 572547003457 G2 box; other site 572547003458 Switch II region; other site 572547003459 G3 box; other site 572547003460 G4 box; other site 572547003461 G5 box; other site 572547003462 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 572547003463 G1 box; other site 572547003464 GTP/Mg2+ binding site [chemical binding]; other site 572547003465 Switch I region; other site 572547003466 G2 box; other site 572547003467 G3 box; other site 572547003468 Switch II region; other site 572547003469 G4 box; other site 572547003470 G5 box; other site 572547003471 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 572547003472 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 572547003473 Flavoprotein; Region: Flavoprotein; pfam02441 572547003474 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 572547003475 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 572547003476 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 572547003477 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 572547003478 catalytic site [active] 572547003479 G-X2-G-X-G-K; other site 572547003480 hypothetical protein; Provisional; Region: PRK04323 572547003481 hypothetical protein; Provisional; Region: PRK11820 572547003482 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 572547003483 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 572547003484 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 572547003485 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 572547003486 HflX GTPase family; Region: HflX; cd01878 572547003487 G1 box; other site 572547003488 GTP/Mg2+ binding site [chemical binding]; other site 572547003489 Switch I region; other site 572547003490 G2 box; other site 572547003491 G3 box; other site 572547003492 Switch II region; other site 572547003493 G4 box; other site 572547003494 G5 box; other site 572547003495 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 572547003496 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 572547003497 putative acyl-acceptor binding pocket; other site 572547003498 cytidylate kinase; Provisional; Region: cmk; PRK00023 572547003499 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 572547003500 CMP-binding site; other site 572547003501 The sites determining sugar specificity; other site 572547003502 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 572547003503 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572547003504 RNA binding surface [nucleotide binding]; other site 572547003505 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 572547003506 active site 572547003507 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 572547003508 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 572547003509 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 572547003510 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 572547003511 active site 572547003512 HIGH motif; other site 572547003513 dimer interface [polypeptide binding]; other site 572547003514 KMSKS motif; other site 572547003515 Uncharacterized conserved protein [Function unknown]; Region: COG0327 572547003516 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 572547003517 Peptidase M15; Region: Peptidase_M15_3; cl01194 572547003518 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 572547003519 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 572547003520 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 572547003521 Baseplate J-like protein; Region: Baseplate_J; cl01294 572547003522 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 572547003523 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 572547003524 Uncharacterized conserved protein [Function unknown]; Region: COG4104 572547003525 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 572547003526 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 572547003527 Phage Tail Protein X; Region: Phage_tail_X; cl02088 572547003528 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 572547003529 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 572547003530 Phage tail tube protein FII; Region: Phage_tube; cl01390 572547003531 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 572547003532 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 572547003533 Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956 572547003534 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 572547003535 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 572547003536 POT family; Region: PTR2; cl17359 572547003537 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 572547003538 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 572547003539 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 572547003540 DNA polymerase III subunit beta; Validated; Region: PRK05643 572547003541 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572547003542 active site 572547003543 DNA binding site [nucleotide binding] 572547003544 Int/Topo IB signature motif; other site 572547003545 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 572547003546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572547003547 Walker A motif; other site 572547003548 ATP binding site [chemical binding]; other site 572547003549 Walker B motif; other site 572547003550 Helix-turn-helix domain; Region: HTH_36; pfam13730 572547003551 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 572547003552 trimer interface [polypeptide binding]; other site 572547003553 active site 572547003554 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 572547003555 Prophage antirepressor [Transcription]; Region: COG3617 572547003556 BRO family, N-terminal domain; Region: Bro-N; smart01040 572547003557 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 572547003558 Helix-turn-helix domain; Region: HTH_17; cl17695 572547003559 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572547003560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572547003561 non-specific DNA binding site [nucleotide binding]; other site 572547003562 salt bridge; other site 572547003563 sequence-specific DNA binding site [nucleotide binding]; other site 572547003564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572547003565 non-specific DNA binding site [nucleotide binding]; other site 572547003566 Predicted transcriptional regulator [Transcription]; Region: COG2932 572547003567 salt bridge; other site 572547003568 sequence-specific DNA binding site [nucleotide binding]; other site 572547003569 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 572547003570 Catalytic site [active] 572547003571 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 572547003572 Catalytic site [active] 572547003573 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 572547003574 putative catalytic site [active] 572547003575 putative metal binding site [ion binding]; other site 572547003576 putative phosphate binding site [ion binding]; other site 572547003577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572547003578 AAA domain; Region: AAA_21; pfam13304 572547003579 Walker A/P-loop; other site 572547003580 ATP binding site [chemical binding]; other site 572547003581 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572547003582 Walker B; other site 572547003583 D-loop; other site 572547003584 H-loop/switch region; other site 572547003585 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 572547003586 oxidoreductase, acting on the CH-CH group of donors; Region: PLN02495 572547003587 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 572547003588 integrase; Provisional; Region: PRK09692 572547003589 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 572547003590 active site 572547003591 Int/Topo IB signature motif; other site 572547003592 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 572547003593 pur operon repressor; Provisional; Region: PRK09213 572547003594 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 572547003595 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572547003596 active site 572547003597 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609 572547003598 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 572547003599 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 572547003600 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 572547003601 G1 box; other site 572547003602 putative GEF interaction site [polypeptide binding]; other site 572547003603 GTP/Mg2+ binding site [chemical binding]; other site 572547003604 Switch I region; other site 572547003605 G2 box; other site 572547003606 G3 box; other site 572547003607 Switch II region; other site 572547003608 G4 box; other site 572547003609 G5 box; other site 572547003610 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 572547003611 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 572547003612 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 572547003613 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 572547003614 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 572547003615 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572547003616 catalytic residue [active] 572547003617 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 572547003618 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 572547003619 CPxP motif; other site 572547003620 DsrE/DsrF-like family; Region: DrsE; pfam02635 572547003621 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 572547003622 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572547003623 FeS/SAM binding site; other site 572547003624 HemN C-terminal domain; Region: HemN_C; pfam06969 572547003625 GTP-binding protein LepA; Provisional; Region: PRK05433 572547003626 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 572547003627 G1 box; other site 572547003628 putative GEF interaction site [polypeptide binding]; other site 572547003629 GTP/Mg2+ binding site [chemical binding]; other site 572547003630 Switch I region; other site 572547003631 G2 box; other site 572547003632 G3 box; other site 572547003633 Switch II region; other site 572547003634 G4 box; other site 572547003635 G5 box; other site 572547003636 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 572547003637 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 572547003638 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 572547003639 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 572547003640 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 572547003641 ATP binding site [chemical binding]; other site 572547003642 active site 572547003643 substrate binding site [chemical binding]; other site 572547003644 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 572547003645 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 572547003646 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 572547003647 putative active site [active] 572547003648 catalytic triad [active] 572547003649 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 572547003650 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 572547003651 dimerization interface [polypeptide binding]; other site 572547003652 ATP binding site [chemical binding]; other site 572547003653 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 572547003654 dimerization interface [polypeptide binding]; other site 572547003655 ATP binding site [chemical binding]; other site 572547003656 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 572547003657 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 572547003658 active site 572547003659 tetramer interface [polypeptide binding]; other site 572547003660 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572547003661 active site 572547003662 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 572547003663 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 572547003664 dimerization interface [polypeptide binding]; other site 572547003665 putative ATP binding site [chemical binding]; other site 572547003666 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 572547003667 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 572547003668 active site 572547003669 substrate binding site [chemical binding]; other site 572547003670 cosubstrate binding site; other site 572547003671 catalytic site [active] 572547003672 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 572547003673 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 572547003674 purine monophosphate binding site [chemical binding]; other site 572547003675 dimer interface [polypeptide binding]; other site 572547003676 putative catalytic residues [active] 572547003677 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 572547003678 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 572547003679 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 572547003680 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 572547003681 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 572547003682 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 572547003683 AIR carboxylase; Region: AIRC; pfam00731 572547003684 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572547003685 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572547003686 substrate binding pocket [chemical binding]; other site 572547003687 membrane-bound complex binding site; other site 572547003688 hinge residues; other site 572547003689 argininosuccinate synthase; Provisional; Region: PRK13820 572547003690 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 572547003691 ANP binding site [chemical binding]; other site 572547003692 Substrate Binding Site II [chemical binding]; other site 572547003693 Substrate Binding Site I [chemical binding]; other site 572547003694 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 572547003695 Peptidase family M50; Region: Peptidase_M50; pfam02163 572547003696 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 572547003697 active site 572547003698 putative substrate binding region [chemical binding]; other site 572547003699 DHH family; Region: DHH; pfam01368 572547003700 FOG: CBS domain [General function prediction only]; Region: COG0517 572547003701 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 572547003702 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 572547003703 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 572547003704 active site 572547003705 NTP binding site [chemical binding]; other site 572547003706 metal binding triad [ion binding]; metal-binding site 572547003707 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 572547003708 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 572547003709 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 572547003710 CoA-binding site [chemical binding]; other site 572547003711 ATP-binding [chemical binding]; other site 572547003712 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 572547003713 Part of AAA domain; Region: AAA_19; pfam13245 572547003714 Family description; Region: UvrD_C_2; pfam13538 572547003715 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572547003716 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 572547003717 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 572547003718 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 572547003719 30S subunit binding site; other site 572547003720 aspartate aminotransferase; Provisional; Region: PRK05764 572547003721 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572547003722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547003723 homodimer interface [polypeptide binding]; other site 572547003724 catalytic residue [active] 572547003725 glyoxylate reductase; Reviewed; Region: PRK13243 572547003726 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 572547003727 dimerization interface [polypeptide binding]; other site 572547003728 ligand binding site [chemical binding]; other site 572547003729 NADP binding site [chemical binding]; other site 572547003730 catalytic site [active] 572547003731 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 572547003732 ribosome recycling factor; Reviewed; Region: frr; PRK00083 572547003733 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 572547003734 hinge region; other site 572547003735 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 572547003736 putative nucleotide binding site [chemical binding]; other site 572547003737 uridine monophosphate binding site [chemical binding]; other site 572547003738 homohexameric interface [polypeptide binding]; other site 572547003739 elongation factor Ts; Reviewed; Region: tsf; PRK12332 572547003740 UBA/TS-N domain; Region: UBA; pfam00627 572547003741 Elongation factor TS; Region: EF_TS; pfam00889 572547003742 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 572547003743 rRNA interaction site [nucleotide binding]; other site 572547003744 S8 interaction site; other site 572547003745 putative laminin-1 binding site; other site 572547003746 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 572547003747 putative homodimer interface [polypeptide binding]; other site 572547003748 putative homotetramer interface [polypeptide binding]; other site 572547003749 putative allosteric switch controlling residues; other site 572547003750 putative metal binding site [ion binding]; other site 572547003751 putative homodimer-homodimer interface [polypeptide binding]; other site 572547003752 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 572547003753 substrate binding site [chemical binding]; other site 572547003754 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 572547003755 peptidase T; Region: peptidase-T; TIGR01882 572547003756 metal binding site [ion binding]; metal-binding site 572547003757 dimer interface [polypeptide binding]; other site 572547003758 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 572547003759 MgtE intracellular N domain; Region: MgtE_N; pfam03448 572547003760 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 572547003761 Divalent cation transporter; Region: MgtE; pfam01769 572547003762 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 572547003763 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 572547003764 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 572547003765 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 572547003766 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 572547003767 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 572547003768 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 572547003769 ATP binding site [chemical binding]; other site 572547003770 Walker A motif; other site 572547003771 hexamer interface [polypeptide binding]; other site 572547003772 Walker B motif; other site 572547003773 Response regulator receiver domain; Region: Response_reg; pfam00072 572547003774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572547003775 active site 572547003776 phosphorylation site [posttranslational modification] 572547003777 intermolecular recognition site; other site 572547003778 dimerization interface [polypeptide binding]; other site 572547003779 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 572547003780 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572547003781 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 572547003782 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 572547003783 BON domain; Region: BON; pfam04972 572547003784 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 572547003785 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 572547003786 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 572547003787 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 572547003788 TadE-like protein; Region: TadE; pfam07811 572547003789 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 572547003790 Flp/Fap pilin component; Region: Flp_Fap; cl01585 572547003791 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572547003792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572547003793 active site 572547003794 phosphorylation site [posttranslational modification] 572547003795 intermolecular recognition site; other site 572547003796 dimerization interface [polypeptide binding]; other site 572547003797 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572547003798 DNA binding residues [nucleotide binding] 572547003799 dimerization interface [polypeptide binding]; other site 572547003800 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 572547003801 Histidine kinase; Region: HisKA_3; pfam07730 572547003802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572547003803 ATP binding site [chemical binding]; other site 572547003804 Mg2+ binding site [ion binding]; other site 572547003805 G-X-G motif; other site 572547003806 putative acyltransferase; Provisional; Region: PRK05790 572547003807 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 572547003808 dimer interface [polypeptide binding]; other site 572547003809 active site 572547003810 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 572547003811 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 572547003812 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 572547003813 DctM-like transporters; Region: DctM; pfam06808 572547003814 hypothetical protein; Provisional; Region: PRK06917 572547003815 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572547003816 inhibitor-cofactor binding pocket; inhibition site 572547003817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547003818 catalytic residue [active] 572547003819 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 572547003820 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 572547003821 HlyD family secretion protein; Region: HlyD_3; pfam13437 572547003822 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 572547003823 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 572547003824 Protein export membrane protein; Region: SecD_SecF; cl14618 572547003825 Protein export membrane protein; Region: SecD_SecF; cl14618 572547003826 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572547003827 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572547003828 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572547003829 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572547003830 metal binding site [ion binding]; metal-binding site 572547003831 active site 572547003832 I-site; other site 572547003833 Cupin domain; Region: Cupin_2; pfam07883 572547003834 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572547003835 Ligand Binding Site [chemical binding]; other site 572547003836 Amidinotransferase; Region: Amidinotransf; cl12043 572547003837 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 572547003838 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 572547003839 L-lactate permease; Region: Lactate_perm; cl00701 572547003840 L-lactate permease; Region: Lactate_perm; cl00701 572547003841 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 572547003842 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 572547003843 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572547003844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547003845 homodimer interface [polypeptide binding]; other site 572547003846 catalytic residue [active] 572547003847 Uncharacterized membrane protein [Function unknown]; Region: COG3949 572547003848 Rubrerythrin [Energy production and conversion]; Region: COG1592 572547003849 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 572547003850 binuclear metal center [ion binding]; other site 572547003851 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 572547003852 iron binding site [ion binding]; other site 572547003853 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 572547003854 nucleoside/Zn binding site; other site 572547003855 dimer interface [polypeptide binding]; other site 572547003856 catalytic motif [active] 572547003857 Predicted amidohydrolase [General function prediction only]; Region: COG0388 572547003858 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 572547003859 active site 572547003860 catalytic triad [active] 572547003861 dimer interface [polypeptide binding]; other site 572547003862 Predicted amidohydrolase [General function prediction only]; Region: COG0388 572547003863 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 572547003864 active site 572547003865 catalytic triad [active] 572547003866 dimer interface [polypeptide binding]; other site 572547003867 Domain of unknown function (DUF386); Region: DUF386; cl01047 572547003868 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 572547003869 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 572547003870 DTAP/Switch II; other site 572547003871 Switch I; other site 572547003872 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 572547003873 active site 1 [active] 572547003874 dimer interface [polypeptide binding]; other site 572547003875 hexamer interface [polypeptide binding]; other site 572547003876 active site 2 [active] 572547003877 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 572547003878 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572547003879 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572547003880 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 572547003881 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 572547003882 oligomer interface [polypeptide binding]; other site 572547003883 putative active site [active] 572547003884 metal binding site [ion binding]; metal-binding site 572547003885 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 572547003886 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 572547003887 MOFRL family; Region: MOFRL; pfam05161 572547003888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 572547003889 YheO-like PAS domain; Region: PAS_6; pfam08348 572547003890 HTH domain; Region: HTH_22; pfam13309 572547003891 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 572547003892 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 572547003893 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 572547003894 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 572547003895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572547003896 motif II; other site 572547003897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572547003898 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 572547003899 active site 572547003900 motif I; other site 572547003901 motif II; other site 572547003902 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 572547003903 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 572547003904 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 572547003905 FeoA domain; Region: FeoA; pfam04023 572547003906 FeoA domain; Region: FeoA; pfam04023 572547003907 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 572547003908 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 572547003909 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 572547003910 G1 box; other site 572547003911 GTP/Mg2+ binding site [chemical binding]; other site 572547003912 Switch I region; other site 572547003913 G2 box; other site 572547003914 G3 box; other site 572547003915 Switch II region; other site 572547003916 G4 box; other site 572547003917 G5 box; other site 572547003918 Nucleoside recognition; Region: Gate; pfam07670 572547003919 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 572547003920 Nucleoside recognition; Region: Gate; pfam07670 572547003921 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 572547003922 Isochorismatase family; Region: Isochorismatase; pfam00857 572547003923 catalytic triad [active] 572547003924 metal binding site [ion binding]; metal-binding site 572547003925 conserved cis-peptide bond; other site 572547003926 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 572547003927 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 572547003928 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572547003929 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572547003930 substrate binding pocket [chemical binding]; other site 572547003931 membrane-bound complex binding site; other site 572547003932 hinge residues; other site 572547003933 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 572547003934 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 572547003935 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 572547003936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572547003937 salt bridge; other site 572547003938 non-specific DNA binding site [nucleotide binding]; other site 572547003939 sequence-specific DNA binding site [nucleotide binding]; other site 572547003940 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 572547003941 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 572547003942 aspartate racemase; Region: asp_race; TIGR00035 572547003943 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 572547003944 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 572547003945 active site 572547003946 8-oxo-dGMP binding site [chemical binding]; other site 572547003947 nudix motif; other site 572547003948 metal binding site [ion binding]; metal-binding site 572547003949 SurA N-terminal domain; Region: SurA_N_3; cl07813 572547003950 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 572547003951 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 572547003952 DNA polymerase I; Provisional; Region: PRK05755 572547003953 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 572547003954 active site 572547003955 metal binding site 1 [ion binding]; metal-binding site 572547003956 putative 5' ssDNA interaction site; other site 572547003957 metal binding site 3; metal-binding site 572547003958 metal binding site 2 [ion binding]; metal-binding site 572547003959 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 572547003960 putative DNA binding site [nucleotide binding]; other site 572547003961 putative metal binding site [ion binding]; other site 572547003962 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 572547003963 active site 572547003964 DNA binding site [nucleotide binding] 572547003965 catalytic site [active] 572547003966 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 572547003967 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 572547003968 DRTGG domain; Region: DRTGG; pfam07085 572547003969 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 572547003970 DHHA2 domain; Region: DHHA2; pfam02833 572547003971 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 572547003972 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 572547003973 active site 572547003974 HIGH motif; other site 572547003975 KMSKS motif; other site 572547003976 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 572547003977 4Fe-4S binding domain; Region: Fer4; pfam00037 572547003978 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572547003979 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 572547003980 NADH dehydrogenase; Region: NADHdh; cl00469 572547003981 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 572547003982 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 572547003983 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 572547003984 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 572547003985 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 572547003986 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08376 572547003987 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572547003988 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 572547003989 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK08386 572547003990 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 572547003991 hypothetical protein; Provisional; Region: PRK08378 572547003992 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12672 572547003993 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 572547003994 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 572547003995 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 572547003996 EamA-like transporter family; Region: EamA; pfam00892 572547003997 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 572547003998 hypothetical protein; Provisional; Region: PRK00955 572547003999 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 572547004000 NAD-dependent deacetylase; Provisional; Region: PRK00481 572547004001 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 572547004002 NAD+ binding site [chemical binding]; other site 572547004003 substrate binding site [chemical binding]; other site 572547004004 Zn binding site [ion binding]; other site 572547004005 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 572547004006 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 572547004007 oligomer interface [polypeptide binding]; other site 572547004008 metal binding site [ion binding]; metal-binding site 572547004009 metal binding site [ion binding]; metal-binding site 572547004010 Cl binding site [ion binding]; other site 572547004011 aspartate ring; other site 572547004012 basic sphincter; other site 572547004013 putative hydrophobic gate; other site 572547004014 periplasmic entrance; other site 572547004015 Chromate transporter; Region: Chromate_transp; pfam02417 572547004016 Chromate transporter; Region: Chromate_transp; pfam02417 572547004017 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572547004018 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 572547004019 putative active site [active] 572547004020 putative metal binding site [ion binding]; other site 572547004021 SPRY domain; Region: SPRY; cl02614 572547004022 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 572547004023 TrkA-N domain; Region: TrkA_N; pfam02254 572547004024 TrkA-C domain; Region: TrkA_C; pfam02080 572547004025 TrkA-N domain; Region: TrkA_N; pfam02254 572547004026 TrkA-C domain; Region: TrkA_C; pfam02080 572547004027 Cation transport protein; Region: TrkH; cl17365 572547004028 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 572547004029 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 572547004030 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 572547004031 TrkA-C domain; Region: TrkA_C; pfam02080 572547004032 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 572547004033 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 572547004034 Domain of unknown function DUF21; Region: DUF21; pfam01595 572547004035 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 572547004036 Transporter associated domain; Region: CorC_HlyC; smart01091 572547004037 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 572547004038 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 572547004039 LrgB-like family; Region: LrgB; pfam04172 572547004040 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 572547004041 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 572547004042 homotrimer interaction site [polypeptide binding]; other site 572547004043 putative active site [active] 572547004044 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 572547004045 homotrimer interaction site [polypeptide binding]; other site 572547004046 putative active site [active] 572547004047 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 572547004048 homotrimer interaction site [polypeptide binding]; other site 572547004049 putative active site [active] 572547004050 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 572547004051 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 572547004052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 572547004053 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 572547004054 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 572547004055 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 572547004056 isocitrate dehydrogenase; Validated; Region: PRK06451 572547004057 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 572547004058 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572547004059 DNA-binding site [nucleotide binding]; DNA binding site 572547004060 FCD domain; Region: FCD; pfam07729 572547004061 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 572547004062 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 572547004063 active site 572547004064 NAD binding site [chemical binding]; other site 572547004065 metal binding site [ion binding]; metal-binding site 572547004066 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 572547004067 DctM-like transporters; Region: DctM; pfam06808 572547004068 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 572547004069 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 572547004070 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 572547004071 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 572547004072 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 572547004073 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cd03174 572547004074 active site 572547004075 catalytic residues [active] 572547004076 metal binding site [ion binding]; metal-binding site 572547004077 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 572547004078 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 572547004079 ligand binding site [chemical binding]; other site 572547004080 NAD binding site [chemical binding]; other site 572547004081 catalytic site [active] 572547004082 Transcriptional regulators [Transcription]; Region: FadR; COG2186 572547004083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572547004084 DNA-binding site [nucleotide binding]; DNA binding site 572547004085 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 572547004086 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 572547004087 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 572547004088 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 572547004089 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 572547004090 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572547004091 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 572547004092 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 572547004093 dimer interface [polypeptide binding]; other site 572547004094 PYR/PP interface [polypeptide binding]; other site 572547004095 TPP binding site [chemical binding]; other site 572547004096 substrate binding site [chemical binding]; other site 572547004097 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 572547004098 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 572547004099 TPP-binding site [chemical binding]; other site 572547004100 putative dimer interface [polypeptide binding]; other site 572547004101 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 572547004102 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 572547004103 tetramer interface [polypeptide binding]; other site 572547004104 active site 572547004105 Mg2+/Mn2+ binding site [ion binding]; other site 572547004106 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 572547004107 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 572547004108 tetramer interface [polypeptide binding]; other site 572547004109 active site 572547004110 Mg2+/Mn2+ binding site [ion binding]; other site 572547004111 DctM-like transporters; Region: DctM; pfam06808 572547004112 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 572547004113 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 572547004114 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 572547004115 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 572547004116 Predicted transcriptional regulators [Transcription]; Region: COG1725 572547004117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572547004118 DNA-binding site [nucleotide binding]; DNA binding site 572547004119 FCD domain; Region: FCD; pfam07729 572547004120 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 572547004121 CoA-transferase family III; Region: CoA_transf_3; pfam02515 572547004122 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 572547004123 active site 572547004124 catalytic residues [active] 572547004125 metal binding site [ion binding]; metal-binding site 572547004126 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 572547004127 anti-sigma E factor; Provisional; Region: rseB; PRK09455 572547004128 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572547004129 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572547004130 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 572547004131 FtsX-like permease family; Region: FtsX; pfam02687 572547004132 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572547004133 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572547004134 Walker A/P-loop; other site 572547004135 ATP binding site [chemical binding]; other site 572547004136 Q-loop/lid; other site 572547004137 ABC transporter signature motif; other site 572547004138 Walker B; other site 572547004139 D-loop; other site 572547004140 H-loop/switch region; other site 572547004141 Domain of unknown function DUF87; Region: DUF87; pfam01935 572547004142 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 572547004143 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572547004144 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 572547004145 Uncharacterized conserved protein [Function unknown]; Region: COG3189 572547004146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572547004147 non-specific DNA binding site [nucleotide binding]; other site 572547004148 salt bridge; other site 572547004149 sequence-specific DNA binding site [nucleotide binding]; other site 572547004150 Domain of unknown function (DUF955); Region: DUF955; cl01076 572547004151 Methyltransferase domain; Region: Methyltransf_26; pfam13659 572547004152 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 572547004153 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 572547004154 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 572547004155 PLD-like domain; Region: PLDc_2; pfam13091 572547004156 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 572547004157 putative homodimer interface [polypeptide binding]; other site 572547004158 putative active site [active] 572547004159 catalytic site [active] 572547004160 DEAD-like helicases superfamily; Region: DEXDc; smart00487 572547004161 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572547004162 ATP binding site [chemical binding]; other site 572547004163 putative Mg++ binding site [ion binding]; other site 572547004164 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 572547004165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572547004166 nucleotide binding region [chemical binding]; other site 572547004167 ATP-binding site [chemical binding]; other site 572547004168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572547004169 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572547004170 putative substrate translocation pore; other site 572547004171 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 572547004172 DctM-like transporters; Region: DctM; pfam06808 572547004173 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 572547004174 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 572547004175 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 572547004176 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 572547004177 Radical SAM superfamily; Region: Radical_SAM; pfam04055 572547004178 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 572547004179 FeS/SAM binding site; other site 572547004180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572547004181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572547004182 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 572547004183 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 572547004184 HlyD family secretion protein; Region: HlyD_3; pfam13437 572547004185 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572547004186 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 572547004187 FtsX-like permease family; Region: FtsX; pfam02687 572547004188 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572547004189 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572547004190 Walker A/P-loop; other site 572547004191 ATP binding site [chemical binding]; other site 572547004192 Q-loop/lid; other site 572547004193 ABC transporter signature motif; other site 572547004194 Walker B; other site 572547004195 D-loop; other site 572547004196 H-loop/switch region; other site 572547004197 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 572547004198 SmpB-tmRNA interface; other site 572547004199 Isochorismatase family; Region: Isochorismatase; pfam00857 572547004200 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 572547004201 catalytic triad [active] 572547004202 dimer interface [polypeptide binding]; other site 572547004203 conserved cis-peptide bond; other site 572547004204 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 572547004205 Malic enzyme, N-terminal domain; Region: malic; pfam00390 572547004206 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 572547004207 NAD(P) binding pocket [chemical binding]; other site 572547004208 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 572547004209 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 572547004210 tetramer interface [polypeptide binding]; other site 572547004211 catalytic Zn binding site [ion binding]; other site 572547004212 NADP binding site [chemical binding]; other site 572547004213 Phospholipid methyltransferase; Region: PEMT; cl17370 572547004214 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 572547004215 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 572547004216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572547004217 active site 572547004218 motif I; other site 572547004219 motif II; other site 572547004220 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 572547004221 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572547004222 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 572547004223 NADP-binding site; other site 572547004224 homotetramer interface [polypeptide binding]; other site 572547004225 substrate binding site [chemical binding]; other site 572547004226 homodimer interface [polypeptide binding]; other site 572547004227 active site 572547004228 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 572547004229 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 572547004230 Substrate binding site; other site 572547004231 Mg++ binding site; other site 572547004232 metal-binding site 572547004233 Mg++ binding site; other site 572547004234 metal-binding site 572547004235 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 572547004236 dimer interface [polypeptide binding]; other site 572547004237 active site 572547004238 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572547004239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572547004240 active site 572547004241 phosphorylation site [posttranslational modification] 572547004242 intermolecular recognition site; other site 572547004243 dimerization interface [polypeptide binding]; other site 572547004244 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572547004245 DNA binding residues [nucleotide binding] 572547004246 dimerization interface [polypeptide binding]; other site 572547004247 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 572547004248 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 572547004249 Ligand Binding Site [chemical binding]; other site 572547004250 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 572547004251 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 572547004252 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 572547004253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572547004254 Walker A/P-loop; other site 572547004255 ATP binding site [chemical binding]; other site 572547004256 Q-loop/lid; other site 572547004257 ABC transporter signature motif; other site 572547004258 Walker B; other site 572547004259 D-loop; other site 572547004260 H-loop/switch region; other site 572547004261 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 572547004262 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 572547004263 active site 572547004264 dimer interface [polypeptide binding]; other site 572547004265 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 572547004266 dimer interface [polypeptide binding]; other site 572547004267 active site 572547004268 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 572547004269 catalytic residues [active] 572547004270 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 572547004271 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 572547004272 FAD binding pocket [chemical binding]; other site 572547004273 FAD binding motif [chemical binding]; other site 572547004274 phosphate binding motif [ion binding]; other site 572547004275 beta-alpha-beta structure motif; other site 572547004276 NAD binding pocket [chemical binding]; other site 572547004277 Iron coordination center [ion binding]; other site 572547004278 putative oxidoreductase; Provisional; Region: PRK12831 572547004279 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572547004280 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572547004281 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 572547004282 elongation factor G; Reviewed; Region: PRK12740 572547004283 G1 box; other site 572547004284 putative GEF interaction site [polypeptide binding]; other site 572547004285 GTP/Mg2+ binding site [chemical binding]; other site 572547004286 Switch I region; other site 572547004287 G2 box; other site 572547004288 G3 box; other site 572547004289 Switch II region; other site 572547004290 G4 box; other site 572547004291 G5 box; other site 572547004292 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 572547004293 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 572547004294 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 572547004295 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 572547004296 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 572547004297 GatB domain; Region: GatB_Yqey; smart00845 572547004298 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 572547004299 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 572547004300 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 572547004301 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 572547004302 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 572547004303 nucleotide binding pocket [chemical binding]; other site 572547004304 K-X-D-G motif; other site 572547004305 catalytic site [active] 572547004306 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 572547004307 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 572547004308 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 572547004309 Dimer interface [polypeptide binding]; other site 572547004310 BRCT sequence motif; other site 572547004311 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 572547004312 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 572547004313 dimer interface [polypeptide binding]; other site 572547004314 putative anticodon binding site; other site 572547004315 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 572547004316 motif 1; other site 572547004317 active site 572547004318 motif 2; other site 572547004319 motif 3; other site 572547004320 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 572547004321 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 572547004322 FMN binding site [chemical binding]; other site 572547004323 active site 572547004324 catalytic residues [active] 572547004325 substrate binding site [chemical binding]; other site 572547004326 pantothenate kinase; Reviewed; Region: PRK13318 572547004327 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 572547004328 Competence protein; Region: Competence; pfam03772 572547004329 SLBB domain; Region: SLBB; pfam10531 572547004330 comEA protein; Region: comE; TIGR01259 572547004331 Helix-hairpin-helix motif; Region: HHH; pfam00633 572547004332 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 572547004333 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 572547004334 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572547004335 FeS/SAM binding site; other site 572547004336 TRAM domain; Region: TRAM; pfam01938 572547004337 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572547004338 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572547004339 substrate binding pocket [chemical binding]; other site 572547004340 membrane-bound complex binding site; other site 572547004341 hinge residues; other site 572547004342 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 572547004343 Rubredoxin; Region: Rubredoxin; pfam00301 572547004344 iron binding site [ion binding]; other site 572547004345 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 572547004346 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 572547004347 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 572547004348 active site 572547004349 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 572547004350 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 572547004351 dimerization interface [polypeptide binding]; other site 572547004352 putative ATP binding site [chemical binding]; other site 572547004353 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 572547004354 transketolase; Reviewed; Region: PRK05899 572547004355 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 572547004356 TPP-binding site [chemical binding]; other site 572547004357 dimer interface [polypeptide binding]; other site 572547004358 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 572547004359 PYR/PP interface [polypeptide binding]; other site 572547004360 dimer interface [polypeptide binding]; other site 572547004361 TPP binding site [chemical binding]; other site 572547004362 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572547004363 alanine racemase; Reviewed; Region: alr; PRK00053 572547004364 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 572547004365 active site 572547004366 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572547004367 dimer interface [polypeptide binding]; other site 572547004368 substrate binding site [chemical binding]; other site 572547004369 catalytic residues [active] 572547004370 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 572547004371 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 572547004372 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 572547004373 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 572547004374 active site 572547004375 potential frameshift: common BLAST hit: gi|269792746|ref|YP_003317650.1| selenoprotein B, glycine/betaine/sarcosine/D- proline reductase 572547004376 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 572547004377 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; pfam07355 572547004378 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 572547004379 putative glycine/sarcosine/betaine reductase complex protein A; Provisional; Region: PRK14717 572547004380 Glycine reductase complex selenoprotein A; Region: GRDA; cl04705 572547004381 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 572547004382 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572547004383 catalytic residues [active] 572547004384 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 572547004385 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 572547004386 Na2 binding site [ion binding]; other site 572547004387 putative substrate binding site 1 [chemical binding]; other site 572547004388 Na binding site 1 [ion binding]; other site 572547004389 putative substrate binding site 2 [chemical binding]; other site 572547004390 HupF/HypC family; Region: HupF_HypC; pfam01455 572547004391 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 572547004392 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 572547004393 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 572547004394 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 572547004395 dimerization interface [polypeptide binding]; other site 572547004396 ATP binding site [chemical binding]; other site 572547004397 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 572547004398 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572547004399 putative active site [active] 572547004400 metal binding site [ion binding]; metal-binding site 572547004401 homodimer binding site [polypeptide binding]; other site 572547004402 phosphodiesterase; Provisional; Region: PRK12704 572547004403 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572547004404 Zn2+ binding site [ion binding]; other site 572547004405 Mg2+ binding site [ion binding]; other site 572547004406 recombination regulator RecX; Reviewed; Region: recX; PRK00117 572547004407 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 572547004408 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 572547004409 ssDNA binding site; other site 572547004410 generic binding surface II; other site 572547004411 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572547004412 ATP binding site [chemical binding]; other site 572547004413 putative Mg++ binding site [ion binding]; other site 572547004414 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572547004415 nucleotide binding region [chemical binding]; other site 572547004416 ATP-binding site [chemical binding]; other site 572547004417 DivIVA protein; Region: DivIVA; pfam05103 572547004418 DivIVA domain; Region: DivI1A_domain; TIGR03544 572547004419 Protein of unknown function (DUF552); Region: DUF552; pfam04472 572547004420 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 572547004421 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572547004422 catalytic residue [active] 572547004423 HlyD family secretion protein; Region: HlyD_2; pfam12700 572547004424 putative membrane fusion protein; Region: TIGR02828 572547004425 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 572547004426 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 572547004427 putative ligand binding site [chemical binding]; other site 572547004428 putative NAD binding site [chemical binding]; other site 572547004429 catalytic site [active] 572547004430 putative GTP cyclohydrolase; Provisional; Region: PRK13674 572547004431 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 572547004432 active site 572547004433 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 572547004434 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 572547004435 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 572547004436 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 572547004437 O-Antigen ligase; Region: Wzy_C; pfam04932 572547004438 replicative DNA helicase; Region: DnaB; TIGR00665 572547004439 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 572547004440 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 572547004441 Walker A motif; other site 572547004442 ATP binding site [chemical binding]; other site 572547004443 Walker B motif; other site 572547004444 DNA binding loops [nucleotide binding] 572547004445 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 572547004446 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 572547004447 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 572547004448 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 572547004449 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 572547004450 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 572547004451 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 572547004452 dimer interface [polypeptide binding]; other site 572547004453 ssDNA binding site [nucleotide binding]; other site 572547004454 tetramer (dimer of dimers) interface [polypeptide binding]; other site 572547004455 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 572547004456 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 572547004457 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 572547004458 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 572547004459 active site 572547004460 HIGH motif; other site 572547004461 KMSK motif region; other site 572547004462 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 572547004463 tRNA binding surface [nucleotide binding]; other site 572547004464 anticodon binding site; other site 572547004465 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 572547004466 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 572547004467 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 572547004468 diaminopimelate aminotransferase; Provisional; Region: PRK13983 572547004469 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650 572547004470 metal binding site [ion binding]; metal-binding site 572547004471 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 572547004472 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 572547004473 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 572547004474 Walker A/P-loop; other site 572547004475 ATP binding site [chemical binding]; other site 572547004476 Q-loop/lid; other site 572547004477 ABC transporter signature motif; other site 572547004478 Walker B; other site 572547004479 D-loop; other site 572547004480 H-loop/switch region; other site 572547004481 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 572547004482 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 572547004483 Walker A/P-loop; other site 572547004484 ATP binding site [chemical binding]; other site 572547004485 Q-loop/lid; other site 572547004486 ABC transporter signature motif; other site 572547004487 Walker B; other site 572547004488 D-loop; other site 572547004489 H-loop/switch region; other site 572547004490 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 572547004491 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 572547004492 TM-ABC transporter signature motif; other site 572547004493 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 572547004494 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 572547004495 TM-ABC transporter signature motif; other site 572547004496 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 572547004497 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 572547004498 putative ligand binding site [chemical binding]; other site 572547004499 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 572547004500 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 572547004501 ATP cone domain; Region: ATP-cone; pfam03477 572547004502 Yqey-like protein; Region: YqeY; pfam09424 572547004503 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 572547004504 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 572547004505 nucleotide binding site/active site [active] 572547004506 HIT family signature motif; other site 572547004507 catalytic residue [active] 572547004508 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 572547004509 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 572547004510 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572547004511 FeS/SAM binding site; other site 572547004512 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 572547004513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572547004514 S-adenosylmethionine binding site [chemical binding]; other site 572547004515 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 572547004516 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 572547004517 HSP70 interaction site [polypeptide binding]; other site 572547004518 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 572547004519 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 572547004520 Zn binding sites [ion binding]; other site 572547004521 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 572547004522 dimer interface [polypeptide binding]; other site 572547004523 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 572547004524 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 572547004525 nucleotide binding site [chemical binding]; other site 572547004526 NEF interaction site [polypeptide binding]; other site 572547004527 SBD interface [polypeptide binding]; other site 572547004528 GrpE; Region: GrpE; pfam01025 572547004529 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 572547004530 dimer interface [polypeptide binding]; other site 572547004531 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 572547004532 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 572547004533 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 572547004534 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572547004535 catalytic core [active] 572547004536 dihydropteroate synthase; Region: DHPS; TIGR01496 572547004537 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 572547004538 substrate binding pocket [chemical binding]; other site 572547004539 dimer interface [polypeptide binding]; other site 572547004540 inhibitor binding site; inhibition site 572547004541 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 572547004542 catalytic center binding site [active] 572547004543 ATP binding site [chemical binding]; other site 572547004544 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 572547004545 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 572547004546 2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11869 572547004547 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 572547004548 TPP-binding site [chemical binding]; other site 572547004549 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 572547004550 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 572547004551 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 572547004552 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 572547004553 dimer interface [polypeptide binding]; other site 572547004554 PYR/PP interface [polypeptide binding]; other site 572547004555 TPP binding site [chemical binding]; other site 572547004556 substrate binding site [chemical binding]; other site 572547004557 Carbon starvation protein CstA; Region: CstA; pfam02554 572547004558 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 572547004559 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 572547004560 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 572547004561 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 572547004562 GDP-binding site [chemical binding]; other site 572547004563 ACT binding site; other site 572547004564 IMP binding site; other site 572547004565 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 572547004566 NodB motif; other site 572547004567 putative active site [active] 572547004568 putative catalytic site [active] 572547004569 Zn binding site [ion binding]; other site 572547004570 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 572547004571 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 572547004572 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 572547004573 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 572547004574 Catalytic dyad [active] 572547004575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 572547004576 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572547004577 Peptidase family M23; Region: Peptidase_M23; pfam01551 572547004578 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 572547004579 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572547004580 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 572547004581 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 572547004582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572547004583 Walker A/P-loop; other site 572547004584 ATP binding site [chemical binding]; other site 572547004585 Q-loop/lid; other site 572547004586 ABC transporter signature motif; other site 572547004587 Walker B; other site 572547004588 D-loop; other site 572547004589 H-loop/switch region; other site 572547004590 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 572547004591 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 572547004592 PYR/PP interface [polypeptide binding]; other site 572547004593 dimer interface [polypeptide binding]; other site 572547004594 TPP binding site [chemical binding]; other site 572547004595 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572547004596 transketolase; Reviewed; Region: PRK05899 572547004597 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 572547004598 TPP-binding site [chemical binding]; other site 572547004599 dimer interface [polypeptide binding]; other site 572547004600 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 572547004601 Maf-like protein; Region: Maf; pfam02545 572547004602 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 572547004603 active site 572547004604 dimer interface [polypeptide binding]; other site 572547004605 Bacitracin resistance protein BacA; Region: BacA; pfam02673 572547004606 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 572547004607 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572547004608 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 572547004609 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 572547004610 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 572547004611 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 572547004612 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 572547004613 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 572547004614 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572547004615 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 572547004616 OstA-like protein; Region: OstA; cl00844 572547004617 NAD:arginine ADP-ribosyltransferase; Region: ART; pfam01129 572547004618 CTP synthetase; Validated; Region: pyrG; PRK05380 572547004619 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 572547004620 Catalytic site [active] 572547004621 active site 572547004622 UTP binding site [chemical binding]; other site 572547004623 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 572547004624 active site 572547004625 putative oxyanion hole; other site 572547004626 catalytic triad [active] 572547004627 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572547004628 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572547004629 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572547004630 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572547004631 Peptidase family M23; Region: Peptidase_M23; pfam01551 572547004632 transcription termination factor Rho; Provisional; Region: rho; PRK09376 572547004633 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 572547004634 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 572547004635 RNA binding site [nucleotide binding]; other site 572547004636 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 572547004637 multimer interface [polypeptide binding]; other site 572547004638 Walker A motif; other site 572547004639 ATP binding site [chemical binding]; other site 572547004640 Walker B motif; other site 572547004641 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 572547004642 active site 572547004643 intersubunit interactions; other site 572547004644 catalytic residue [active] 572547004645 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 572547004646 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 572547004647 6-phosphofructokinase; Provisional; Region: PRK03202 572547004648 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 572547004649 active site 572547004650 ADP/pyrophosphate binding site [chemical binding]; other site 572547004651 dimerization interface [polypeptide binding]; other site 572547004652 allosteric effector site; other site 572547004653 fructose-1,6-bisphosphate binding site; other site 572547004654 S-layer homology domain; Region: SLH; pfam00395 572547004655 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 572547004656 O-Antigen ligase; Region: Wzy_C; pfam04932 572547004657 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 572547004658 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 572547004659 putative active site [active] 572547004660 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 572547004661 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572547004662 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572547004663 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 572547004664 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 572547004665 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 572547004666 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 572547004667 Ligand binding site; other site 572547004668 oligomer interface; other site 572547004669 deoxyhypusine synthase; Region: dhys; TIGR00321 572547004670 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 572547004671 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 572547004672 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 572547004673 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 572547004674 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 572547004675 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 572547004676 putative active site [active] 572547004677 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 572547004678 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 572547004679 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 572547004680 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 572547004681 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 572547004682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 572547004683 conserved hypothetical protein; Region: TIGR03492 572547004684 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 572547004685 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572547004686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572547004687 Walker A/P-loop; other site 572547004688 ATP binding site [chemical binding]; other site 572547004689 Q-loop/lid; other site 572547004690 ABC transporter signature motif; other site 572547004691 Walker B; other site 572547004692 D-loop; other site 572547004693 H-loop/switch region; other site 572547004694 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 572547004695 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 572547004696 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 572547004697 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 572547004698 Predicted permeases [General function prediction only]; Region: COG0795 572547004699 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 572547004700 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 572547004701 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 572547004702 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 572547004703 active site 572547004704 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 572547004705 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 572547004706 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 572547004707 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 572547004708 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 572547004709 trimer interface [polypeptide binding]; other site 572547004710 active site 572547004711 UDP-GlcNAc binding site [chemical binding]; other site 572547004712 lipid binding site [chemical binding]; lipid-binding site 572547004713 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 572547004714 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 572547004715 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 572547004716 Surface antigen; Region: Bac_surface_Ag; pfam01103 572547004717 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 572547004718 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572547004719 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 572547004720 DNA binding residues [nucleotide binding] 572547004721 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572547004722 catalytic core [active] 572547004723 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572547004724 Beta-lactamase; Region: Beta-lactamase; pfam00144 572547004725 argininosuccinate lyase; Provisional; Region: PRK00855 572547004726 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 572547004727 active sites [active] 572547004728 tetramer interface [polypeptide binding]; other site 572547004729 Protein of unknown function (DUF501); Region: DUF501; pfam04417 572547004730 general stress protein 13; Validated; Region: PRK08059 572547004731 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 572547004732 RNA binding site [nucleotide binding]; other site 572547004733 Response regulator receiver domain; Region: Response_reg; pfam00072 572547004734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572547004735 active site 572547004736 phosphorylation site [posttranslational modification] 572547004737 intermolecular recognition site; other site 572547004738 dimerization interface [polypeptide binding]; other site 572547004739 transcriptional repressor CodY; Validated; Region: PRK04158 572547004740 CodY GAF-like domain; Region: CodY; pfam06018 572547004741 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 572547004742 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 572547004743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572547004744 Walker A motif; other site 572547004745 ATP binding site [chemical binding]; other site 572547004746 Walker B motif; other site 572547004747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572547004748 Walker B motif; other site 572547004749 arginine finger; other site 572547004750 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 572547004751 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 572547004752 active site 572547004753 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 572547004754 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572547004755 active site 572547004756 DNA binding site [nucleotide binding] 572547004757 Int/Topo IB signature motif; other site 572547004758 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 572547004759 Glucose inhibited division protein A; Region: GIDA; pfam01134 572547004760 DNA topoisomerase I; Validated; Region: PRK05582 572547004761 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 572547004762 active site 572547004763 interdomain interaction site; other site 572547004764 putative metal-binding site [ion binding]; other site 572547004765 nucleotide binding site [chemical binding]; other site 572547004766 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 572547004767 domain I; other site 572547004768 DNA binding groove [nucleotide binding] 572547004769 phosphate binding site [ion binding]; other site 572547004770 domain II; other site 572547004771 domain III; other site 572547004772 nucleotide binding site [chemical binding]; other site 572547004773 catalytic site [active] 572547004774 domain IV; other site 572547004775 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 572547004776 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 572547004777 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572547004778 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 572547004779 DNA protecting protein DprA; Region: dprA; TIGR00732 572547004780 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 572547004781 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 572547004782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572547004783 Walker A motif; other site 572547004784 ATP binding site [chemical binding]; other site 572547004785 Walker B motif; other site 572547004786 arginine finger; other site 572547004787 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 572547004788 hypothetical protein; Reviewed; Region: PRK12497 572547004789 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 572547004790 RNA/DNA hybrid binding site [nucleotide binding]; other site 572547004791 active site 572547004792 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 572547004793 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 572547004794 GTP/Mg2+ binding site [chemical binding]; other site 572547004795 G4 box; other site 572547004796 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 572547004797 G1 box; other site 572547004798 G1 box; other site 572547004799 GTP/Mg2+ binding site [chemical binding]; other site 572547004800 Switch I region; other site 572547004801 G2 box; other site 572547004802 G3 box; other site 572547004803 G3 box; other site 572547004804 Switch II region; other site 572547004805 Switch II region; other site 572547004806 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 572547004807 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 572547004808 Catalytic site [active] 572547004809 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 572547004810 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 572547004811 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 572547004812 dimer interface [polypeptide binding]; other site 572547004813 PYR/PP interface [polypeptide binding]; other site 572547004814 TPP binding site [chemical binding]; other site 572547004815 substrate binding site [chemical binding]; other site 572547004816 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 572547004817 TPP-binding site; other site 572547004818 4Fe-4S binding domain; Region: Fer4; pfam00037 572547004819 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 572547004820 active site 572547004821 CoA binding domain; Region: CoA_binding_2; pfam13380 572547004822 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 572547004823 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 572547004824 Divalent cation transporter; Region: MgtE; cl00786 572547004825 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 572547004826 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 572547004827 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 572547004828 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 572547004829 Catalytic site [active] 572547004830 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 572547004831 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 572547004832 Potassium binding sites [ion binding]; other site 572547004833 Cesium cation binding sites [ion binding]; other site 572547004834 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 572547004835 glutamate formiminotransferase; Region: FtcD; TIGR02024 572547004836 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 572547004837 Formiminotransferase domain; Region: FTCD; pfam02971 572547004838 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 572547004839 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 572547004840 DctM-like transporters; Region: DctM; pfam06808 572547004841 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 572547004842 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 572547004843 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 572547004844 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 572547004845 metal binding site [ion binding]; metal-binding site 572547004846 dimer interface [polypeptide binding]; other site 572547004847 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 572547004848 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 572547004849 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 572547004850 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 572547004851 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 572547004852 homodimer interface [polypeptide binding]; other site 572547004853 NADP binding site [chemical binding]; other site 572547004854 substrate binding site [chemical binding]; other site 572547004855 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 572547004856 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 572547004857 Potassium binding sites [ion binding]; other site 572547004858 Cesium cation binding sites [ion binding]; other site 572547004859 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 572547004860 hypothetical protein; Reviewed; Region: PRK09588 572547004861 Archease protein family (MTH1598/TM1083); Region: Archease; cl00606 572547004862 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 572547004863 Uncharacterized conserved protein [Function unknown]; Region: COG2006 572547004864 Domain of unknown function (DUF362); Region: DUF362; pfam04015 572547004865 4Fe-4S binding domain; Region: Fer4; cl02805 572547004866 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 572547004867 4Fe-4S binding domain; Region: Fer4; pfam00037 572547004868 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 572547004869 nickel binding site [ion binding]; other site 572547004870 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 572547004871 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 572547004872 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 572547004873 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572547004874 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 572547004875 catalytic loop [active] 572547004876 iron binding site [ion binding]; other site 572547004877 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 572547004878 4Fe-4S binding domain; Region: Fer4; pfam00037 572547004879 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 572547004880 molybdopterin cofactor binding site; other site 572547004881 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 572547004882 dimer interface [polypeptide binding]; other site 572547004883 [2Fe-2S] cluster binding site [ion binding]; other site 572547004884 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 572547004885 SLBB domain; Region: SLBB; pfam10531 572547004886 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 572547004887 4Fe-4S binding domain; Region: Fer4; pfam00037 572547004888 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 572547004889 4Fe-4S binding domain; Region: Fer4; pfam00037 572547004890 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 572547004891 dimer interface [polypeptide binding]; other site 572547004892 [2Fe-2S] cluster binding site [ion binding]; other site 572547004893 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 572547004894 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 572547004895 putative dimer interface [polypeptide binding]; other site 572547004896 [2Fe-2S] cluster binding site [ion binding]; other site 572547004897 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572547004898 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 572547004899 Walker A/P-loop; other site 572547004900 ATP binding site [chemical binding]; other site 572547004901 Q-loop/lid; other site 572547004902 ABC transporter signature motif; other site 572547004903 Walker B; other site 572547004904 D-loop; other site 572547004905 H-loop/switch region; other site 572547004906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 572547004907 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 572547004908 PBP superfamily domain; Region: PBP_like_2; pfam12849 572547004909 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 572547004910 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 572547004911 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 572547004912 active site 572547004913 metal-binding site [ion binding] 572547004914 nucleotide-binding site [chemical binding]; other site 572547004915 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 572547004916 ATP cone domain; Region: ATP-cone; pfam03477 572547004917 Class III ribonucleotide reductase; Region: RNR_III; cd01675 572547004918 effector binding site; other site 572547004919 active site 572547004920 Zn binding site [ion binding]; other site 572547004921 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 572547004922 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572547004923 FeS/SAM binding site; other site 572547004924 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 572547004925 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 572547004926 Walker A/P-loop; other site 572547004927 ATP binding site [chemical binding]; other site 572547004928 Q-loop/lid; other site 572547004929 ABC transporter signature motif; other site 572547004930 Walker B; other site 572547004931 D-loop; other site 572547004932 H-loop/switch region; other site 572547004933 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 572547004934 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 572547004935 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 572547004936 TM-ABC transporter signature motif; other site 572547004937 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 572547004938 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 572547004939 TM-ABC transporter signature motif; other site 572547004940 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 572547004941 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 572547004942 ligand binding site [chemical binding]; other site 572547004943 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 572547004944 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 572547004945 active site 572547004946 metal binding site [ion binding]; metal-binding site 572547004947 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 572547004948 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 572547004949 Fe-S cluster binding site [ion binding]; other site 572547004950 active site 572547004951 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 572547004952 active site 572547004953 catalytic site [active] 572547004954 substrate binding site [chemical binding]; other site 572547004955 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 572547004956 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 572547004957 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 572547004958 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 572547004959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572547004960 Walker A/P-loop; other site 572547004961 ATP binding site [chemical binding]; other site 572547004962 Q-loop/lid; other site 572547004963 ABC transporter signature motif; other site 572547004964 Walker B; other site 572547004965 D-loop; other site 572547004966 H-loop/switch region; other site 572547004967 TOBE domain; Region: TOBE_2; pfam08402 572547004968 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 572547004969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547004970 putative PBP binding loops; other site 572547004971 ABC-ATPase subunit interface; other site 572547004972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547004973 dimer interface [polypeptide binding]; other site 572547004974 conserved gate region; other site 572547004975 putative PBP binding loops; other site 572547004976 ABC-ATPase subunit interface; other site 572547004977 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 572547004978 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 572547004979 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 572547004980 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 572547004981 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 572547004982 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 572547004983 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 572547004984 glycine cleavage system protein H; Provisional; Region: PRK13380 572547004985 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 572547004986 lipoyl attachment site [posttranslational modification]; other site 572547004987 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 572547004988 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 572547004989 tetramer interface [polypeptide binding]; other site 572547004990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547004991 catalytic residue [active] 572547004992 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 572547004993 tetramer interface [polypeptide binding]; other site 572547004994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547004995 catalytic residue [active] 572547004996 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 572547004997 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572547004998 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 572547004999 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572547005000 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572547005001 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 572547005002 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 572547005003 E3 interaction surface; other site 572547005004 lipoyl attachment site [posttranslational modification]; other site 572547005005 e3 binding domain; Region: E3_binding; pfam02817 572547005006 e3 binding domain; Region: E3_binding; pfam02817 572547005007 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 572547005008 DctM-like transporters; Region: DctM; pfam06808 572547005009 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 572547005010 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 572547005011 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 572547005012 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 572547005013 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 572547005014 trimer interface [polypeptide binding]; other site 572547005015 putative Zn binding site [ion binding]; other site 572547005016 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 572547005017 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 572547005018 alpha subunit interface [polypeptide binding]; other site 572547005019 TPP binding site [chemical binding]; other site 572547005020 heterodimer interface [polypeptide binding]; other site 572547005021 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572547005022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 572547005023 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 572547005024 tetramer interface [polypeptide binding]; other site 572547005025 TPP-binding site [chemical binding]; other site 572547005026 heterodimer interface [polypeptide binding]; other site 572547005027 phosphorylation loop region [posttranslational modification] 572547005028 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572547005029 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 572547005030 DNA-binding site [nucleotide binding]; DNA binding site 572547005031 FCD domain; Region: FCD; pfam07729 572547005032 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 572547005033 putative ADP-ribose binding site [chemical binding]; other site 572547005034 putative active site [active] 572547005035 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572547005036 active site 572547005037 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 572547005038 active site 572547005039 dimer interface [polypeptide binding]; other site 572547005040 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 572547005041 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 572547005042 heterodimer interface [polypeptide binding]; other site 572547005043 active site 572547005044 FMN binding site [chemical binding]; other site 572547005045 homodimer interface [polypeptide binding]; other site 572547005046 substrate binding site [chemical binding]; other site 572547005047 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 572547005048 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 572547005049 FAD binding pocket [chemical binding]; other site 572547005050 FAD binding motif [chemical binding]; other site 572547005051 phosphate binding motif [ion binding]; other site 572547005052 beta-alpha-beta structure motif; other site 572547005053 NAD binding pocket [chemical binding]; other site 572547005054 Iron coordination center [ion binding]; other site 572547005055 dihydroorotase; Validated; Region: pyrC; PRK09357 572547005056 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572547005057 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 572547005058 active site 572547005059 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 572547005060 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 572547005061 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 572547005062 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 572547005063 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572547005064 active site 572547005065 aspartate aminotransferase; Provisional; Region: PRK07568 572547005066 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572547005067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547005068 homodimer interface [polypeptide binding]; other site 572547005069 catalytic residue [active] 572547005070 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 572547005071 oligomerization interface [polypeptide binding]; other site 572547005072 active site 572547005073 metal binding site [ion binding]; metal-binding site 572547005074 Transcriptional regulator [Transcription]; Region: IclR; COG1414 572547005075 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 572547005076 Bacterial transcriptional regulator; Region: IclR; pfam01614 572547005077 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572547005078 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 572547005079 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 572547005080 putative catalytic site [active] 572547005081 putative phosphate binding site [ion binding]; other site 572547005082 active site 572547005083 metal binding site A [ion binding]; metal-binding site 572547005084 DNA binding site [nucleotide binding] 572547005085 putative AP binding site [nucleotide binding]; other site 572547005086 putative metal binding site B [ion binding]; other site 572547005087 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 572547005088 EamA-like transporter family; Region: EamA; pfam00892 572547005089 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165 572547005090 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 572547005091 putative ligand binding site [chemical binding]; other site 572547005092 NAD binding site [chemical binding]; other site 572547005093 dimer interface [polypeptide binding]; other site 572547005094 putative catalytic site [active] 572547005095 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 572547005096 diiron binding motif [ion binding]; other site 572547005097 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 572547005098 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572547005099 acyl-activating enzyme (AAE) consensus motif; other site 572547005100 AMP binding site [chemical binding]; other site 572547005101 active site 572547005102 CoA binding site [chemical binding]; other site 572547005103 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 572547005104 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 572547005105 metal binding site [ion binding]; metal-binding site 572547005106 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 572547005107 AIR carboxylase; Region: AIRC; smart01001 572547005108 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 572547005109 HD domain; Region: HD_3; pfam13023 572547005110 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 572547005111 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 572547005112 metal binding site [ion binding]; metal-binding site 572547005113 dimer interface [polypeptide binding]; other site 572547005114 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572547005115 catalytic residues [active] 572547005116 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 572547005117 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 572547005118 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 572547005119 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 572547005120 dimer interface [polypeptide binding]; other site 572547005121 decamer (pentamer of dimers) interface [polypeptide binding]; other site 572547005122 catalytic triad [active] 572547005123 peroxidatic and resolving cysteines [active] 572547005124 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 572547005125 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 572547005126 G1 box; other site 572547005127 putative GEF interaction site [polypeptide binding]; other site 572547005128 GTP/Mg2+ binding site [chemical binding]; other site 572547005129 Switch I region; other site 572547005130 G2 box; other site 572547005131 G3 box; other site 572547005132 Switch II region; other site 572547005133 G4 box; other site 572547005134 G5 box; other site 572547005135 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 572547005136 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 572547005137 GAF domain; Region: GAF; pfam01590 572547005138 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 572547005139 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 572547005140 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 572547005141 GAF domain; Region: GAF; cl17456 572547005142 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572547005143 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572547005144 metal binding site [ion binding]; metal-binding site 572547005145 active site 572547005146 I-site; other site 572547005147 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 572547005148 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 572547005149 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 572547005150 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 572547005151 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 572547005152 Cupin domain; Region: Cupin_2; pfam07883 572547005153 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572547005154 PAS domain; Region: PAS_9; pfam13426 572547005155 putative active site [active] 572547005156 heme pocket [chemical binding]; other site 572547005157 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 572547005158 GAF domain; Region: GAF; cl17456 572547005159 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 572547005160 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 572547005161 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 572547005162 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572547005163 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 572547005164 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572547005165 DNA binding residues [nucleotide binding] 572547005166 Peptidase family C69; Region: Peptidase_C69; cl17793 572547005167 potential frameshift: common BLAST hit: gi|157364025|ref|YP_001470792.1| succinylglutamate desuccinylase/aspartoacylase 572547005168 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 572547005169 active site 572547005170 Zn binding site [ion binding]; other site 572547005171 DDE domain; Region: DDE_Tnp_IS240; pfam13610 572547005172 Peptidase family C69; Region: Peptidase_C69; cl17793 572547005173 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 572547005174 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 572547005175 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 572547005176 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 572547005177 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 572547005178 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 572547005179 catalytic residues [active] 572547005180 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 572547005181 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 572547005182 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 572547005183 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572547005184 motif II; other site 572547005185 homoserine dehydrogenase; Provisional; Region: PRK06270 572547005186 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 572547005187 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 572547005188 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 572547005189 Part of AAA domain; Region: AAA_19; pfam13245 572547005190 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 572547005191 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 572547005192 Uncharacterized conserved protein [Function unknown]; Region: COG1284 572547005193 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572547005194 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572547005195 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 572547005196 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 572547005197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572547005198 Mg2+ binding site [ion binding]; other site 572547005199 G-X-G motif; other site 572547005200 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 572547005201 anchoring element; other site 572547005202 dimer interface [polypeptide binding]; other site 572547005203 ATP binding site [chemical binding]; other site 572547005204 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 572547005205 active site 572547005206 putative metal-binding site [ion binding]; other site 572547005207 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 572547005208 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 572547005209 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 572547005210 active site 572547005211 dimer interface [polypeptide binding]; other site 572547005212 multifunctional aminopeptidase A; Provisional; Region: PRK00913 572547005213 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 572547005214 interface (dimer of trimers) [polypeptide binding]; other site 572547005215 Substrate-binding/catalytic site; other site 572547005216 Zn-binding sites [ion binding]; other site 572547005217 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 572547005218 homodimer interface [polypeptide binding]; other site 572547005219 homotetramer interface [polypeptide binding]; other site 572547005220 active site pocket [active] 572547005221 cleavage site 572547005222 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 572547005223 SxDxEG motif; other site 572547005224 active site 572547005225 metal binding site [ion binding]; metal-binding site 572547005226 homopentamer interface [polypeptide binding]; other site 572547005227 Transcriptional regulators [Transcription]; Region: GntR; COG1802 572547005228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572547005229 DNA-binding site [nucleotide binding]; DNA binding site 572547005230 FCD domain; Region: FCD; pfam07729 572547005231 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 572547005232 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 572547005233 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 572547005234 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 572547005235 metal binding site [ion binding]; metal-binding site 572547005236 dimer interface [polypeptide binding]; other site 572547005237 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 572547005238 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 572547005239 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 572547005240 active site 572547005241 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 572547005242 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 572547005243 PRA1 family protein; Region: PRA1; cl02137 572547005244 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 572547005245 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572547005246 Walker A/P-loop; other site 572547005247 ATP binding site [chemical binding]; other site 572547005248 Q-loop/lid; other site 572547005249 ABC transporter signature motif; other site 572547005250 Walker B; other site 572547005251 D-loop; other site 572547005252 H-loop/switch region; other site 572547005253 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 572547005254 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 572547005255 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572547005256 Walker A/P-loop; other site 572547005257 ATP binding site [chemical binding]; other site 572547005258 Q-loop/lid; other site 572547005259 ABC transporter signature motif; other site 572547005260 Walker B; other site 572547005261 D-loop; other site 572547005262 H-loop/switch region; other site 572547005263 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 572547005264 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 572547005265 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 572547005266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547005267 dimer interface [polypeptide binding]; other site 572547005268 conserved gate region; other site 572547005269 putative PBP binding loops; other site 572547005270 ABC-ATPase subunit interface; other site 572547005271 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 572547005272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547005273 dimer interface [polypeptide binding]; other site 572547005274 conserved gate region; other site 572547005275 putative PBP binding loops; other site 572547005276 ABC-ATPase subunit interface; other site 572547005277 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 572547005278 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 572547005279 active site 572547005280 NTP binding site [chemical binding]; other site 572547005281 metal binding triad [ion binding]; metal-binding site 572547005282 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 572547005283 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 572547005284 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 572547005285 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 572547005286 active site 572547005287 intersubunit interface [polypeptide binding]; other site 572547005288 catalytic residue [active] 572547005289 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 572547005290 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 572547005291 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 572547005292 Walker A/P-loop; other site 572547005293 ATP binding site [chemical binding]; other site 572547005294 Q-loop/lid; other site 572547005295 ABC transporter signature motif; other site 572547005296 Walker B; other site 572547005297 D-loop; other site 572547005298 H-loop/switch region; other site 572547005299 NIL domain; Region: NIL; pfam09383 572547005300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547005301 dimer interface [polypeptide binding]; other site 572547005302 conserved gate region; other site 572547005303 ABC-ATPase subunit interface; other site 572547005304 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 572547005305 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 572547005306 galactonate dehydratase; Provisional; Region: PRK14017 572547005307 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 572547005308 putative active site pocket [active] 572547005309 putative metal binding site [ion binding]; other site 572547005310 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 572547005311 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 572547005312 substrate binding site [chemical binding]; other site 572547005313 ATP binding site [chemical binding]; other site 572547005314 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 572547005315 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 572547005316 active site 572547005317 intersubunit interface [polypeptide binding]; other site 572547005318 catalytic residue [active] 572547005319 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 572547005320 Transcriptional regulator [Transcription]; Region: IclR; COG1414 572547005321 Bacterial transcriptional regulator; Region: IclR; pfam01614 572547005322 DctM-like transporters; Region: DctM; pfam06808 572547005323 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 572547005324 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 572547005325 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 572547005326 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 572547005327 galactarate dehydratase; Region: galactar-dH20; TIGR03248 572547005328 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 572547005329 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 572547005330 PBP superfamily domain; Region: PBP_like_2; cl17296 572547005331 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 572547005332 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 572547005333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547005334 dimer interface [polypeptide binding]; other site 572547005335 conserved gate region; other site 572547005336 putative PBP binding loops; other site 572547005337 ABC-ATPase subunit interface; other site 572547005338 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 572547005339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547005340 dimer interface [polypeptide binding]; other site 572547005341 conserved gate region; other site 572547005342 putative PBP binding loops; other site 572547005343 ABC-ATPase subunit interface; other site 572547005344 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 572547005345 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 572547005346 Walker A/P-loop; other site 572547005347 ATP binding site [chemical binding]; other site 572547005348 Q-loop/lid; other site 572547005349 ABC transporter signature motif; other site 572547005350 Walker B; other site 572547005351 D-loop; other site 572547005352 H-loop/switch region; other site 572547005353 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 572547005354 PhoU domain; Region: PhoU; pfam01895 572547005355 PhoU domain; Region: PhoU; pfam01895 572547005356 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572547005357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572547005358 active site 572547005359 phosphorylation site [posttranslational modification] 572547005360 intermolecular recognition site; other site 572547005361 dimerization interface [polypeptide binding]; other site 572547005362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572547005363 DNA binding site [nucleotide binding] 572547005364 HAMP domain; Region: HAMP; pfam00672 572547005365 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572547005366 PAS domain; Region: PAS; smart00091 572547005367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572547005368 dimer interface [polypeptide binding]; other site 572547005369 phosphorylation site [posttranslational modification] 572547005370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572547005371 ATP binding site [chemical binding]; other site 572547005372 G-X-G motif; other site 572547005373 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 572547005374 aspartate racemase; Region: asp_race; TIGR00035 572547005375 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 572547005376 putative active site [active] 572547005377 putative metal binding site [ion binding]; other site 572547005378 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572547005379 putative DNA binding site [nucleotide binding]; other site 572547005380 Transcriptional regulator [Transcription]; Region: IclR; COG1414 572547005381 putative Zn2+ binding site [ion binding]; other site 572547005382 Bacterial transcriptional regulator; Region: IclR; pfam01614 572547005383 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 572547005384 DctM-like transporters; Region: DctM; pfam06808 572547005385 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 572547005386 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 572547005387 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 572547005388 4-aminobutyrate aminotransferase; Provisional; Region: PRK08360 572547005389 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572547005390 inhibitor-cofactor binding pocket; inhibition site 572547005391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547005392 catalytic residue [active] 572547005393 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 572547005394 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 572547005395 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572547005396 catalytic residue [active] 572547005397 Predicted membrane protein [Function unknown]; Region: COG2364 572547005398 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572547005399 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 572547005400 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 572547005401 YibE/F-like protein; Region: YibE_F; pfam07907 572547005402 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 572547005403 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 572547005404 dimer interface [polypeptide binding]; other site 572547005405 active site 572547005406 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 572547005407 active site 572547005408 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 572547005409 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 572547005410 tetramer interface [polypeptide binding]; other site 572547005411 active site 572547005412 Mg2+/Mn2+ binding site [ion binding]; other site 572547005413 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 572547005414 DctM-like transporters; Region: DctM; pfam06808 572547005415 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 572547005416 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 572547005417 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 572547005418 substrate binding site [chemical binding]; other site 572547005419 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 572547005420 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 572547005421 substrate binding site [chemical binding]; other site 572547005422 ligand binding site [chemical binding]; other site 572547005423 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 572547005424 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 572547005425 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 572547005426 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 572547005427 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 572547005428 Repressor of nif and glnA expression [Transcription]; Region: COG1693 572547005429 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 572547005430 Domain of unknown function DUF128; Region: DUF128; pfam01995 572547005431 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 572547005432 Chain length determinant protein; Region: Wzz; pfam02706 572547005433 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 572547005434 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 572547005435 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 572547005436 SLBB domain; Region: SLBB; pfam10531 572547005437 SLBB domain; Region: SLBB; pfam10531 572547005438 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 572547005439 SLBB domain; Region: SLBB; pfam10531 572547005440 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 572547005441 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 572547005442 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 572547005443 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 572547005444 NAD(P) binding site [chemical binding]; other site 572547005445 homodimer interface [polypeptide binding]; other site 572547005446 substrate binding site [chemical binding]; other site 572547005447 active site 572547005448 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 572547005449 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 572547005450 inhibitor-cofactor binding pocket; inhibition site 572547005451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547005452 catalytic residue [active] 572547005453 Bacterial sugar transferase; Region: Bac_transf; pfam02397 572547005454 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 572547005455 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 572547005456 putative trimer interface [polypeptide binding]; other site 572547005457 putative CoA binding site [chemical binding]; other site 572547005458 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 572547005459 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572547005460 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 572547005461 active site 572547005462 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 572547005463 homodimer interface [polypeptide binding]; other site 572547005464 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 572547005465 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572547005466 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 572547005467 putative trimer interface [polypeptide binding]; other site 572547005468 putative CoA binding site [chemical binding]; other site 572547005469 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 572547005470 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 572547005471 dimer interface [polypeptide binding]; other site 572547005472 active site 572547005473 CoA binding pocket [chemical binding]; other site 572547005474 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 572547005475 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 572547005476 classical (c) SDRs; Region: SDR_c; cd05233 572547005477 NAD(P) binding site [chemical binding]; other site 572547005478 active site 572547005479 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 572547005480 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 572547005481 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 572547005482 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 572547005483 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 572547005484 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 572547005485 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 572547005486 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 572547005487 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 572547005488 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 572547005489 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 572547005490 NAD binding site [chemical binding]; other site 572547005491 substrate binding site [chemical binding]; other site 572547005492 homodimer interface [polypeptide binding]; other site 572547005493 active site 572547005494 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 572547005495 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 572547005496 trimer interface [polypeptide binding]; other site 572547005497 active site 572547005498 substrate binding site [chemical binding]; other site 572547005499 CoA binding site [chemical binding]; other site 572547005500 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 572547005501 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 572547005502 inhibitor-cofactor binding pocket; inhibition site 572547005503 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547005504 catalytic residue [active] 572547005505 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 572547005506 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 572547005507 substrate binding site; other site 572547005508 tetramer interface; other site 572547005509 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 572547005510 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572547005511 dimerization interface [polypeptide binding]; other site 572547005512 putative DNA binding site [nucleotide binding]; other site 572547005513 putative Zn2+ binding site [ion binding]; other site 572547005514 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 572547005515 EamA-like transporter family; Region: EamA; pfam00892 572547005516 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 572547005517 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572547005518 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 572547005519 Peptidase M15; Region: Peptidase_M15_3; cl01194 572547005520 YvrJ protein family; Region: YvrJ; pfam12841 572547005521 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 572547005522 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 572547005523 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 572547005524 M20 Peptidase Aminoacylase 1-like protein 2, amidohydrolase family; Region: M20_Acy1L2_like_2; cd09849 572547005525 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 572547005526 metal binding site [ion binding]; metal-binding site 572547005527 Domain of unknown function (DUF955); Region: DUF955; pfam06114 572547005528 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572547005529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572547005530 non-specific DNA binding site [nucleotide binding]; other site 572547005531 salt bridge; other site 572547005532 sequence-specific DNA binding site [nucleotide binding]; other site 572547005533 DctM-like transporters; Region: DctM; pfam06808 572547005534 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 572547005535 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 572547005536 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 572547005537 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 572547005538 aspartate aminotransferase; Provisional; Region: PRK05764 572547005539 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572547005540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547005541 homodimer interface [polypeptide binding]; other site 572547005542 catalytic residue [active] 572547005543 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 572547005544 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 572547005545 ligand binding site [chemical binding]; other site 572547005546 NAD binding site [chemical binding]; other site 572547005547 catalytic site [active] 572547005548 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 572547005549 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 572547005550 active site 572547005551 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 572547005552 ATP-NAD kinase; Region: NAD_kinase; pfam01513 572547005553 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 572547005554 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572547005555 catalytic residue [active] 572547005556 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 572547005557 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 572547005558 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572547005559 catalytic residue [active] 572547005560 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 572547005561 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 572547005562 active site 572547005563 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 572547005564 DctM-like transporters; Region: DctM; pfam06808 572547005565 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 572547005566 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 572547005567 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 572547005568 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 572547005569 Transcriptional regulators [Transcription]; Region: GntR; COG1802 572547005570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572547005571 DNA-binding site [nucleotide binding]; DNA binding site 572547005572 FCD domain; Region: FCD; pfam07729 572547005573 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 572547005574 Domain of unknown function DUF20; Region: UPF0118; pfam01594 572547005575 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 572547005576 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572547005577 catalytic residue [active] 572547005578 D-cysteine desulfhydrase; Validated; Region: PRK03910 572547005579 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 572547005580 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572547005581 catalytic residue [active] 572547005582 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 572547005583 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572547005584 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572547005585 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 572547005586 Class I aldolases; Region: Aldolase_Class_I; cl17187 572547005587 catalytic residue [active] 572547005588 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 572547005589 homotrimer interaction site [polypeptide binding]; other site 572547005590 putative active site [active] 572547005591 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 572547005592 DctM-like transporters; Region: DctM; pfam06808 572547005593 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 572547005594 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 572547005595 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 572547005596 Transcriptional regulators [Transcription]; Region: FadR; COG2186 572547005597 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 572547005598 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572547005599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572547005600 S-adenosylmethionine binding site [chemical binding]; other site 572547005601 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 572547005602 DNA-binding site [nucleotide binding]; DNA binding site 572547005603 RNA-binding motif; other site 572547005604 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 572547005605 Homeodomain-like domain; Region: HTH_23; pfam13384 572547005606 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 572547005607 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 572547005608 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 572547005609 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 572547005610 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 572547005611 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 572547005612 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 572547005613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 572547005614 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 572547005615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547005616 dimer interface [polypeptide binding]; other site 572547005617 conserved gate region; other site 572547005618 putative PBP binding loops; other site 572547005619 ABC-ATPase subunit interface; other site 572547005620 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 572547005621 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572547005622 Walker A/P-loop; other site 572547005623 ATP binding site [chemical binding]; other site 572547005624 Q-loop/lid; other site 572547005625 ABC transporter signature motif; other site 572547005626 Walker B; other site 572547005627 D-loop; other site 572547005628 H-loop/switch region; other site 572547005629 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 572547005630 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572547005631 Walker A/P-loop; other site 572547005632 ATP binding site [chemical binding]; other site 572547005633 Q-loop/lid; other site 572547005634 ABC transporter signature motif; other site 572547005635 Walker B; other site 572547005636 D-loop; other site 572547005637 H-loop/switch region; other site 572547005638 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 572547005639 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572547005640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572547005641 putative substrate translocation pore; other site 572547005642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572547005643 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 572547005644 RNA/DNA hybrid binding site [nucleotide binding]; other site 572547005645 active site 572547005646 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 572547005647 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 572547005648 NADP binding site [chemical binding]; other site 572547005649 active site 572547005650 putative substrate binding site [chemical binding]; other site 572547005651 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 572547005652 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 572547005653 dimer interface [polypeptide binding]; other site 572547005654 active site 572547005655 glycine-pyridoxal phosphate binding site [chemical binding]; other site 572547005656 folate binding site [chemical binding]; other site 572547005657 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 572547005658 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 572547005659 substrate-cofactor binding pocket; other site 572547005660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547005661 catalytic residue [active] 572547005662 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572547005663 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 572547005664 NAD binding site [chemical binding]; other site 572547005665 homodimer interface [polypeptide binding]; other site 572547005666 active site 572547005667 putative substrate binding site [chemical binding]; other site 572547005668 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 572547005669 Malic enzyme, N-terminal domain; Region: malic; pfam00390 572547005670 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 572547005671 putative NAD(P) binding site [chemical binding]; other site 572547005672 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 572547005673 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572547005674 acyl-activating enzyme (AAE) consensus motif; other site 572547005675 AMP binding site [chemical binding]; other site 572547005676 active site 572547005677 CoA binding site [chemical binding]; other site 572547005678 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 572547005679 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 572547005680 Ligand Binding Site [chemical binding]; other site 572547005681 Protein of unknown function DUF111; Region: DUF111; pfam01969 572547005682 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 572547005683 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 572547005684 dimer interface [polypeptide binding]; other site 572547005685 active site 572547005686 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572547005687 substrate binding site [chemical binding]; other site 572547005688 catalytic residue [active] 572547005689 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 572547005690 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 572547005691 metal binding site [ion binding]; metal-binding site 572547005692 dimer interface [polypeptide binding]; other site 572547005693 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 572547005694 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 572547005695 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572547005696 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572547005697 dipeptidase PepV; Reviewed; Region: PRK07318 572547005698 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 572547005699 active site 572547005700 metal binding site [ion binding]; metal-binding site 572547005701 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 572547005702 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 572547005703 nucleotide binding site [chemical binding]; other site 572547005704 NEF interaction site [polypeptide binding]; other site 572547005705 SBD interface [polypeptide binding]; other site 572547005706 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 572547005707 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 572547005708 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 572547005709 DctM-like transporters; Region: DctM; pfam06808 572547005710 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 572547005711 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 572547005712 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572547005713 membrane-bound complex binding site; other site 572547005714 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 572547005715 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 572547005716 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 572547005717 putative active site [active] 572547005718 Uncharacterized conserved protein [Function unknown]; Region: COG4717 572547005719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572547005720 Walker A/P-loop; other site 572547005721 ATP binding site [chemical binding]; other site 572547005722 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 572547005723 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572547005724 active site 572547005725 metal binding site [ion binding]; metal-binding site 572547005726 DNA binding site [nucleotide binding] 572547005727 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 572547005728 transmembrane helices; other site 572547005729 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 572547005730 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 572547005731 Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248 572547005732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572547005733 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572547005734 putative substrate translocation pore; other site 572547005735 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 572547005736 HTH domain; Region: HTH_11; pfam08279 572547005737 3H domain; Region: 3H; pfam02829 572547005738 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 572547005739 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 572547005740 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572547005741 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572547005742 metal binding site [ion binding]; metal-binding site 572547005743 active site 572547005744 I-site; other site 572547005745 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 572547005746 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 572547005747 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572547005748 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572547005749 dimerization interface [polypeptide binding]; other site 572547005750 putative Zn2+ binding site [ion binding]; other site 572547005751 putative DNA binding site [nucleotide binding]; other site 572547005752 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 572547005753 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 572547005754 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 572547005755 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 572547005756 Ligand binding site; other site 572547005757 DXD motif; other site 572547005758 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 572547005759 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 572547005760 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 572547005761 putative NADH binding site [chemical binding]; other site 572547005762 putative active site [active] 572547005763 nudix motif; other site 572547005764 putative metal binding site [ion binding]; other site 572547005765 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 572547005766 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572547005767 Zn2+ binding site [ion binding]; other site 572547005768 Mg2+ binding site [ion binding]; other site 572547005769 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 572547005770 dimer interface [polypeptide binding]; other site 572547005771 catalytic triad [active] 572547005772 peroxidatic and resolving cysteines [active] 572547005773 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 572547005774 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 572547005775 Class I aldolases; Region: Aldolase_Class_I; cl17187 572547005776 catalytic residue [active] 572547005777 allantoate amidohydrolase; Reviewed; Region: PRK09290 572547005778 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 572547005779 active site 572547005780 metal binding site [ion binding]; metal-binding site 572547005781 dimer interface [polypeptide binding]; other site 572547005782 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 572547005783 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 572547005784 inhibitor site; inhibition site 572547005785 active site 572547005786 dimer interface [polypeptide binding]; other site 572547005787 catalytic residue [active] 572547005788 DctM-like transporters; Region: DctM; pfam06808 572547005789 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 572547005790 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 572547005791 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 572547005792 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 572547005793 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 572547005794 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572547005795 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 572547005796 active site 572547005797 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572547005798 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 572547005799 active site 572547005800 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 572547005801 Transcriptional regulator [Transcription]; Region: IclR; COG1414 572547005802 Bacterial transcriptional regulator; Region: IclR; pfam01614 572547005803 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 572547005804 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572547005805 catalytic residue [active] 572547005806 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 572547005807 Transcriptional regulator [Transcription]; Region: IclR; COG1414 572547005808 Bacterial transcriptional regulator; Region: IclR; pfam01614 572547005809 butyrate kinase; Provisional; Region: PRK03011 572547005810 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 572547005811 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 572547005812 butyrate kinase; Provisional; Region: PRK03011 572547005813 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 572547005814 PAS domain S-box; Region: sensory_box; TIGR00229 572547005815 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572547005816 putative active site [active] 572547005817 heme pocket [chemical binding]; other site 572547005818 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 572547005819 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572547005820 Zn2+ binding site [ion binding]; other site 572547005821 Mg2+ binding site [ion binding]; other site 572547005822 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 572547005823 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 572547005824 homodimer interface [polypeptide binding]; other site 572547005825 substrate-cofactor binding pocket; other site 572547005826 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572547005827 catalytic residue [active] 572547005828 photolyase PhrII; Region: phr2; TIGR00591 572547005829 DNA photolyase; Region: DNA_photolyase; pfam00875 572547005830 BioY family; Region: BioY; pfam02632 572547005831 Uncharacterized conserved protein [Function unknown]; Region: COG1739 572547005832 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 572547005833 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 572547005834 nucleotide binding site/active site [active] 572547005835 HIT family signature motif; other site 572547005836 catalytic residue [active] 572547005837 ParB-like nuclease domain; Region: ParB; smart00470 572547005838 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 572547005839 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 572547005840 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572547005841 P-loop; other site 572547005842 Magnesium ion binding site [ion binding]; other site 572547005843 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572547005844 Magnesium ion binding site [ion binding]; other site 572547005845 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 572547005846 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 572547005847 Staphylococcal nuclease homologues; Region: SNc; smart00318 572547005848 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 572547005849 Catalytic site; other site 572547005850 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 572547005851 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 572547005852 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 572547005853 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 572547005854 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 572547005855 metal binding site [ion binding]; metal-binding site 572547005856 dimer interface [polypeptide binding]; other site 572547005857 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 572547005858 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 572547005859 metal binding site [ion binding]; metal-binding site 572547005860 dimer interface [polypeptide binding]; other site 572547005861 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 572547005862 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572547005863 ABC-ATPase subunit interface; other site 572547005864 dimer interface [polypeptide binding]; other site 572547005865 putative PBP binding regions; other site 572547005866 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 572547005867 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 572547005868 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 572547005869 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 572547005870 putative metal binding residues [ion binding]; other site 572547005871 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 572547005872 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572547005873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572547005874 active site 572547005875 phosphorylation site [posttranslational modification] 572547005876 intermolecular recognition site; other site 572547005877 dimerization interface [polypeptide binding]; other site 572547005878 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572547005879 DNA binding residues [nucleotide binding] 572547005880 dimerization interface [polypeptide binding]; other site 572547005881 PAS domain; Region: PAS_9; pfam13426 572547005882 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572547005883 putative active site [active] 572547005884 heme pocket [chemical binding]; other site 572547005885 PAS domain; Region: PAS; smart00091 572547005886 PAS domain S-box; Region: sensory_box; TIGR00229 572547005887 PAS domain S-box; Region: sensory_box; TIGR00229 572547005888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572547005889 putative active site [active] 572547005890 heme pocket [chemical binding]; other site 572547005891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 572547005892 Histidine kinase; Region: HisKA_3; pfam07730 572547005893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572547005894 ATP binding site [chemical binding]; other site 572547005895 Mg2+ binding site [ion binding]; other site 572547005896 G-X-G motif; other site 572547005897 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 572547005898 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 572547005899 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 572547005900 putative active site [active] 572547005901 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 572547005902 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 572547005903 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 572547005904 Transcriptional regulators [Transcription]; Region: GntR; COG1802 572547005905 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572547005906 DNA-binding site [nucleotide binding]; DNA binding site 572547005907 FCD domain; Region: FCD; pfam07729 572547005908 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 572547005909 Predicted amidohydrolase [General function prediction only]; Region: COG0388 572547005910 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 572547005911 putative active site [active] 572547005912 catalytic triad [active] 572547005913 putative dimer interface [polypeptide binding]; other site 572547005914 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 572547005915 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 572547005916 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 572547005917 DctM-like transporters; Region: DctM; pfam06808 572547005918 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 572547005919 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 572547005920 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 572547005921 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 572547005922 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 572547005923 putative NAD(P) binding site [chemical binding]; other site 572547005924 putative active site [active] 572547005925 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 572547005926 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 572547005927 active site 572547005928 catalytic tetrad [active] 572547005929 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572547005930 Transcriptional regulator [Transcription]; Region: IclR; COG1414 572547005931 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 572547005932 Bacterial transcriptional regulator; Region: IclR; pfam01614 572547005933 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 572547005934 imidazolonepropionase; Validated; Region: PRK09356 572547005935 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 572547005936 active site 572547005937 urocanate hydratase; Provisional; Region: PRK05414 572547005938 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 572547005939 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 572547005940 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 572547005941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547005942 dimer interface [polypeptide binding]; other site 572547005943 conserved gate region; other site 572547005944 putative PBP binding loops; other site 572547005945 ABC-ATPase subunit interface; other site 572547005946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572547005947 dimer interface [polypeptide binding]; other site 572547005948 conserved gate region; other site 572547005949 putative PBP binding loops; other site 572547005950 ABC-ATPase subunit interface; other site 572547005951 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 572547005952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572547005953 Walker A/P-loop; other site 572547005954 ATP binding site [chemical binding]; other site 572547005955 Q-loop/lid; other site 572547005956 ABC transporter signature motif; other site 572547005957 Walker B; other site 572547005958 D-loop; other site 572547005959 H-loop/switch region; other site 572547005960 TOBE domain; Region: TOBE_2; pfam08402 572547005961 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 572547005962 nucleotide binding site [chemical binding]; other site 572547005963 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 572547005964 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 572547005965 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 572547005966 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 572547005967 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 572547005968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 572547005969 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 572547005970 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 572547005971 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 572547005972 metal-binding site [ion binding] 572547005973 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572547005974 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 572547005975 metal binding site [ion binding]; metal-binding site 572547005976 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572547005977 motif II; other site 572547005978 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 572547005979 metal-binding site [ion binding] 572547005980 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 572547005981 Sensory domain found in PocR; Region: PocR; pfam10114 572547005982 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572547005983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572547005984 ATP binding site [chemical binding]; other site 572547005985 Mg2+ binding site [ion binding]; other site 572547005986 G-X-G motif; other site 572547005987 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572547005988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572547005989 active site 572547005990 phosphorylation site [posttranslational modification] 572547005991 intermolecular recognition site; other site 572547005992 dimerization interface [polypeptide binding]; other site 572547005993 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572547005994 DNA binding residues [nucleotide binding] 572547005995 dimerization interface [polypeptide binding]; other site 572547005996 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 572547005997 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 572547005998 dimer interface [polypeptide binding]; other site 572547005999 active site 572547006000 glycine-pyridoxal phosphate binding site [chemical binding]; other site 572547006001 folate binding site [chemical binding]; other site 572547006002 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 572547006003 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 572547006004 metal binding site [ion binding]; metal-binding site 572547006005 dimer interface [polypeptide binding]; other site 572547006006 hypothetical protein; Provisional; Region: PRK04164 572547006007 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 572547006008 peptidase T-like protein; Region: PepT-like; TIGR01883 572547006009 metal binding site [ion binding]; metal-binding site 572547006010 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 572547006011 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 572547006012 active sites [active] 572547006013 tetramer interface [polypeptide binding]; other site 572547006014 hybrid cluster protein; Provisional; Region: PRK05290 572547006015 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572547006016 ACS interaction site; other site 572547006017 CODH interaction site; other site 572547006018 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 572547006019 hybrid metal cluster; other site 572547006020 Ferredoxin [Energy production and conversion]; Region: COG1146 572547006021 4Fe-4S binding domain; Region: Fer4_6; pfam12837 572547006022 Predicted transcriptional regulator [Transcription]; Region: COG1959 572547006023 Transcriptional regulator; Region: Rrf2; pfam02082 572547006024 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 572547006025 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 572547006026 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572547006027 catalytic residue [active] 572547006028 Double zinc ribbon; Region: DZR; pfam12773 572547006029 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 572547006030 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 572547006031 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 572547006032 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 572547006033 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 572547006034 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 572547006035 Double zinc ribbon; Region: DZR; pfam12773 572547006036 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 572547006037 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 572547006038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572547006039 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572547006040 putative substrate translocation pore; other site 572547006041 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404