-- dump date 20140618_202640 -- class Genbank::misc_feature -- table misc_feature_note -- id note 698758000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 698758000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 698758000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758000004 Walker A motif; other site 698758000005 ATP binding site [chemical binding]; other site 698758000006 Walker B motif; other site 698758000007 arginine finger; other site 698758000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698758000009 DnaA box-binding interface [nucleotide binding]; other site 698758000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 698758000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 698758000012 putative DNA binding surface [nucleotide binding]; other site 698758000013 dimer interface [polypeptide binding]; other site 698758000014 beta-clamp/clamp loader binding surface; other site 698758000015 beta-clamp/translesion DNA polymerase binding surface; other site 698758000016 S4 domain; Region: S4_2; pfam13275 698758000017 recombination protein F; Reviewed; Region: recF; PRK00064 698758000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 698758000019 Walker A/P-loop; other site 698758000020 ATP binding site [chemical binding]; other site 698758000021 Q-loop/lid; other site 698758000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758000023 ABC transporter signature motif; other site 698758000024 Walker B; other site 698758000025 D-loop; other site 698758000026 H-loop/switch region; other site 698758000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698758000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758000029 ATP binding site [chemical binding]; other site 698758000030 Mg2+ binding site [ion binding]; other site 698758000031 G-X-G motif; other site 698758000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698758000033 anchoring element; other site 698758000034 dimer interface [polypeptide binding]; other site 698758000035 ATP binding site [chemical binding]; other site 698758000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698758000037 active site 698758000038 putative metal-binding site [ion binding]; other site 698758000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698758000040 DNA gyrase subunit A; Validated; Region: PRK05560 698758000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698758000042 CAP-like domain; other site 698758000043 active site 698758000044 primary dimer interface [polypeptide binding]; other site 698758000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698758000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698758000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698758000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698758000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698758000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698758000051 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698758000052 Zn2+ binding site [ion binding]; other site 698758000053 Mg2+ binding site [ion binding]; other site 698758000054 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 698758000055 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698758000056 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 698758000057 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 698758000058 active site 698758000059 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 698758000060 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698758000061 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 698758000062 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 698758000063 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 698758000064 active site 698758000065 multimer interface [polypeptide binding]; other site 698758000066 seryl-tRNA synthetase; Provisional; Region: PRK05431 698758000067 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 698758000068 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 698758000069 dimer interface [polypeptide binding]; other site 698758000070 active site 698758000071 motif 1; other site 698758000072 motif 2; other site 698758000073 motif 3; other site 698758000074 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698758000075 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698758000076 active site 698758000077 catalytic tetrad [active] 698758000078 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 698758000079 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 698758000080 Spore germination protein; Region: Spore_permease; cl17796 698758000081 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 698758000082 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 698758000083 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698758000084 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698758000085 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 698758000086 active site 698758000087 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698758000088 nucleoside/Zn binding site; other site 698758000089 dimer interface [polypeptide binding]; other site 698758000090 catalytic motif [active] 698758000091 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 698758000092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758000093 Walker A motif; other site 698758000094 ATP binding site [chemical binding]; other site 698758000095 Walker B motif; other site 698758000096 arginine finger; other site 698758000097 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 698758000098 hypothetical protein; Validated; Region: PRK00153 698758000099 recombination protein RecR; Reviewed; Region: recR; PRK00076 698758000100 RecR protein; Region: RecR; pfam02132 698758000101 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 698758000102 putative active site [active] 698758000103 putative metal-binding site [ion binding]; other site 698758000104 tetramer interface [polypeptide binding]; other site 698758000105 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 698758000106 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 698758000107 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698758000108 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698758000109 Walker A/P-loop; other site 698758000110 ATP binding site [chemical binding]; other site 698758000111 Q-loop/lid; other site 698758000112 ABC transporter signature motif; other site 698758000113 Walker B; other site 698758000114 D-loop; other site 698758000115 H-loop/switch region; other site 698758000116 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698758000117 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698758000118 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698758000119 Walker A/P-loop; other site 698758000120 ATP binding site [chemical binding]; other site 698758000121 Q-loop/lid; other site 698758000122 ABC transporter signature motif; other site 698758000123 Walker B; other site 698758000124 D-loop; other site 698758000125 H-loop/switch region; other site 698758000126 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698758000127 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698758000128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758000129 dimer interface [polypeptide binding]; other site 698758000130 conserved gate region; other site 698758000131 putative PBP binding loops; other site 698758000132 ABC-ATPase subunit interface; other site 698758000133 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698758000134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758000135 dimer interface [polypeptide binding]; other site 698758000136 conserved gate region; other site 698758000137 ABC-ATPase subunit interface; other site 698758000138 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 698758000139 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698758000140 peptide binding site [polypeptide binding]; other site 698758000141 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 698758000142 thymidylate kinase; Validated; Region: tmk; PRK00698 698758000143 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 698758000144 TMP-binding site; other site 698758000145 ATP-binding site [chemical binding]; other site 698758000146 Protein of unknown function (DUF970); Region: DUF970; pfam06153 698758000147 Protein of unknown function (DUF327); Region: DUF327; pfam03885 698758000148 DNA polymerase III subunit delta'; Validated; Region: PRK08058 698758000149 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 698758000150 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 698758000151 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 698758000152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758000153 S-adenosylmethionine binding site [chemical binding]; other site 698758000154 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 698758000155 GIY-YIG motif/motif A; other site 698758000156 putative active site [active] 698758000157 putative metal binding site [ion binding]; other site 698758000158 Predicted methyltransferases [General function prediction only]; Region: COG0313 698758000159 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 698758000160 putative SAM binding site [chemical binding]; other site 698758000161 putative homodimer interface [polypeptide binding]; other site 698758000162 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 698758000163 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 698758000164 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 698758000165 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 698758000166 active site 698758000167 HIGH motif; other site 698758000168 KMSKS motif; other site 698758000169 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 698758000170 anticodon binding site; other site 698758000171 tRNA binding surface [nucleotide binding]; other site 698758000172 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 698758000173 dimer interface [polypeptide binding]; other site 698758000174 putative tRNA-binding site [nucleotide binding]; other site 698758000175 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 698758000176 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698758000177 active site 698758000178 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698758000179 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698758000180 G5 domain; Region: G5; pfam07501 698758000181 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 698758000182 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 698758000183 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 698758000184 putative active site [active] 698758000185 putative metal binding site [ion binding]; other site 698758000186 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 698758000187 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 698758000188 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 698758000189 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 698758000190 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 698758000191 putative active site [active] 698758000192 putative NTP binding site [chemical binding]; other site 698758000193 putative nucleic acid binding site [nucleotide binding]; other site 698758000194 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 698758000195 YabG peptidase U57; Region: Peptidase_U57; pfam05582 698758000196 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 698758000197 pur operon repressor; Provisional; Region: PRK09213 698758000198 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 698758000199 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698758000200 active site 698758000201 regulatory protein SpoVG; Reviewed; Region: PRK13259 698758000202 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 698758000203 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 698758000204 Substrate binding site; other site 698758000205 Mg++ binding site; other site 698758000206 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 698758000207 active site 698758000208 substrate binding site [chemical binding]; other site 698758000209 CoA binding site [chemical binding]; other site 698758000210 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 698758000211 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698758000212 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698758000213 active site 698758000214 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 698758000215 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 698758000216 5S rRNA interface [nucleotide binding]; other site 698758000217 CTC domain interface [polypeptide binding]; other site 698758000218 L16 interface [polypeptide binding]; other site 698758000219 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698758000220 putative active site [active] 698758000221 catalytic residue [active] 698758000222 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 698758000223 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 698758000224 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 698758000225 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698758000226 ATP binding site [chemical binding]; other site 698758000227 putative Mg++ binding site [ion binding]; other site 698758000228 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698758000229 nucleotide binding region [chemical binding]; other site 698758000230 ATP-binding site [chemical binding]; other site 698758000231 TRCF domain; Region: TRCF; pfam03461 698758000232 stage V sporulation protein T; Region: spore_V_T; TIGR02851 698758000233 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 698758000234 GAF domain; Region: GAF; cl17456 698758000235 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 698758000236 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 698758000237 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 698758000238 putative SAM binding site [chemical binding]; other site 698758000239 putative homodimer interface [polypeptide binding]; other site 698758000240 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 698758000241 homodimer interface [polypeptide binding]; other site 698758000242 metal binding site [ion binding]; metal-binding site 698758000243 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 698758000244 homodimer interface [polypeptide binding]; other site 698758000245 active site 698758000246 putative chemical substrate binding site [chemical binding]; other site 698758000247 metal binding site [ion binding]; metal-binding site 698758000248 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698758000249 RNA binding surface [nucleotide binding]; other site 698758000250 sporulation protein YabP; Region: spore_yabP; TIGR02892 698758000251 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 698758000252 hypothetical protein; Provisional; Region: PRK08582 698758000253 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 698758000254 RNA binding site [nucleotide binding]; other site 698758000255 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698758000256 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698758000257 substrate binding pocket [chemical binding]; other site 698758000258 chain length determination region; other site 698758000259 substrate-Mg2+ binding site; other site 698758000260 catalytic residues [active] 698758000261 aspartate-rich region 1; other site 698758000262 active site lid residues [active] 698758000263 aspartate-rich region 2; other site 698758000264 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 698758000265 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 698758000266 trimer interface [polypeptide binding]; other site 698758000267 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698758000268 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698758000269 Predicted membrane protein [Function unknown]; Region: COG2259 698758000270 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 698758000271 ApbE family; Region: ApbE; pfam02424 698758000272 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 698758000273 UbiA prenyltransferase family; Region: UbiA; pfam01040 698758000274 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 698758000275 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698758000276 Walker A/P-loop; other site 698758000277 ATP binding site [chemical binding]; other site 698758000278 Q-loop/lid; other site 698758000279 ABC transporter signature motif; other site 698758000280 Walker B; other site 698758000281 D-loop; other site 698758000282 H-loop/switch region; other site 698758000283 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 698758000284 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698758000285 Walker A/P-loop; other site 698758000286 ATP binding site [chemical binding]; other site 698758000287 Q-loop/lid; other site 698758000288 ABC transporter signature motif; other site 698758000289 Walker B; other site 698758000290 D-loop; other site 698758000291 H-loop/switch region; other site 698758000292 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698758000293 stage II sporulation protein E; Region: spore_II_E; TIGR02865 698758000294 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 698758000295 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 698758000296 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698758000297 metal ion-dependent adhesion site (MIDAS); other site 698758000298 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698758000299 active site 698758000300 ATP binding site [chemical binding]; other site 698758000301 substrate binding site [chemical binding]; other site 698758000302 activation loop (A-loop); other site 698758000303 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 698758000304 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698758000305 Ligand Binding Site [chemical binding]; other site 698758000306 TilS substrate C-terminal domain; Region: TilS_C; smart00977 698758000307 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698758000308 active site 698758000309 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 698758000310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758000311 Walker A motif; other site 698758000312 ATP binding site [chemical binding]; other site 698758000313 Walker B motif; other site 698758000314 arginine finger; other site 698758000315 Peptidase family M41; Region: Peptidase_M41; pfam01434 698758000316 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698758000317 nucleotide binding site [chemical binding]; other site 698758000318 Type III pantothenate kinase; Region: Pan_kinase; cl17198 698758000319 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 698758000320 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 698758000321 dimerization interface [polypeptide binding]; other site 698758000322 domain crossover interface; other site 698758000323 redox-dependent activation switch; other site 698758000324 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 698758000325 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698758000326 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698758000327 dimer interface [polypeptide binding]; other site 698758000328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698758000329 catalytic residue [active] 698758000330 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698758000331 dihydropteroate synthase; Region: DHPS; TIGR01496 698758000332 substrate binding pocket [chemical binding]; other site 698758000333 dimer interface [polypeptide binding]; other site 698758000334 inhibitor binding site; inhibition site 698758000335 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698758000336 homooctamer interface [polypeptide binding]; other site 698758000337 active site 698758000338 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698758000339 catalytic center binding site [active] 698758000340 ATP binding site [chemical binding]; other site 698758000341 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698758000342 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698758000343 non-specific DNA binding site [nucleotide binding]; other site 698758000344 salt bridge; other site 698758000345 sequence-specific DNA binding site [nucleotide binding]; other site 698758000346 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 698758000347 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698758000348 dimer interface [polypeptide binding]; other site 698758000349 putative anticodon binding site; other site 698758000350 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 698758000351 motif 1; other site 698758000352 active site 698758000353 motif 2; other site 698758000354 motif 3; other site 698758000355 EDD domain protein, DegV family; Region: DegV; TIGR00762 698758000356 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698758000357 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 698758000358 MgtC family; Region: MgtC; pfam02308 698758000359 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 698758000360 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 698758000361 UvrB/uvrC motif; Region: UVR; pfam02151 698758000362 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 698758000363 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 698758000364 ADP binding site [chemical binding]; other site 698758000365 phosphagen binding site; other site 698758000366 substrate specificity loop; other site 698758000367 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 698758000368 Clp amino terminal domain; Region: Clp_N; pfam02861 698758000369 Clp amino terminal domain; Region: Clp_N; pfam02861 698758000370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758000371 Walker A motif; other site 698758000372 ATP binding site [chemical binding]; other site 698758000373 Walker B motif; other site 698758000374 arginine finger; other site 698758000375 UvrB/uvrC motif; Region: UVR; pfam02151 698758000376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758000377 Walker A motif; other site 698758000378 ATP binding site [chemical binding]; other site 698758000379 Walker B motif; other site 698758000380 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698758000381 DNA repair protein RadA; Provisional; Region: PRK11823 698758000382 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 698758000383 Walker A motif/ATP binding site; other site 698758000384 ATP binding site [chemical binding]; other site 698758000385 Walker B motif; other site 698758000386 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698758000387 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 698758000388 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 698758000389 putative active site [active] 698758000390 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 698758000391 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698758000392 HIGH motif; other site 698758000393 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698758000394 active site 698758000395 KMSKS motif; other site 698758000396 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 698758000397 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 698758000398 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698758000399 trimer interface [polypeptide binding]; other site 698758000400 active site 698758000401 substrate binding site [chemical binding]; other site 698758000402 CoA binding site [chemical binding]; other site 698758000403 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 698758000404 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 698758000405 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698758000406 active site 698758000407 HIGH motif; other site 698758000408 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698758000409 KMSKS motif; other site 698758000410 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 698758000411 tRNA binding surface [nucleotide binding]; other site 698758000412 anticodon binding site; other site 698758000413 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 698758000414 active site 698758000415 metal binding site [ion binding]; metal-binding site 698758000416 dimerization interface [polypeptide binding]; other site 698758000417 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 698758000418 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 698758000419 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698758000420 YacP-like NYN domain; Region: NYN_YacP; pfam05991 698758000421 RNA polymerase factor sigma-70; Validated; Region: PRK08295 698758000422 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698758000423 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 698758000424 DNA binding residues [nucleotide binding] 698758000425 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 698758000426 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 698758000427 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698758000428 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 698758000429 putative homodimer interface [polypeptide binding]; other site 698758000430 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 698758000431 heterodimer interface [polypeptide binding]; other site 698758000432 homodimer interface [polypeptide binding]; other site 698758000433 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 698758000434 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 698758000435 23S rRNA interface [nucleotide binding]; other site 698758000436 L7/L12 interface [polypeptide binding]; other site 698758000437 putative thiostrepton binding site; other site 698758000438 L25 interface [polypeptide binding]; other site 698758000439 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 698758000440 mRNA/rRNA interface [nucleotide binding]; other site 698758000441 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 698758000442 23S rRNA interface [nucleotide binding]; other site 698758000443 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 698758000444 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 698758000445 core dimer interface [polypeptide binding]; other site 698758000446 peripheral dimer interface [polypeptide binding]; other site 698758000447 L10 interface [polypeptide binding]; other site 698758000448 L11 interface [polypeptide binding]; other site 698758000449 putative EF-Tu interaction site [polypeptide binding]; other site 698758000450 putative EF-G interaction site [polypeptide binding]; other site 698758000451 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 698758000452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758000453 S-adenosylmethionine binding site [chemical binding]; other site 698758000454 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 698758000455 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 698758000456 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 698758000457 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698758000458 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698758000459 RPB1 interaction site [polypeptide binding]; other site 698758000460 RPB12 interaction site [polypeptide binding]; other site 698758000461 RPB10 interaction site [polypeptide binding]; other site 698758000462 RPB11 interaction site [polypeptide binding]; other site 698758000463 RPB3 interaction site [polypeptide binding]; other site 698758000464 RPB12 interaction site [polypeptide binding]; other site 698758000465 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 698758000466 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 698758000467 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 698758000468 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 698758000469 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 698758000470 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698758000471 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 698758000472 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 698758000473 G-loop; other site 698758000474 DNA binding site [nucleotide binding] 698758000475 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 698758000476 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 698758000477 S17 interaction site [polypeptide binding]; other site 698758000478 S8 interaction site; other site 698758000479 16S rRNA interaction site [nucleotide binding]; other site 698758000480 streptomycin interaction site [chemical binding]; other site 698758000481 23S rRNA interaction site [nucleotide binding]; other site 698758000482 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 698758000483 30S ribosomal protein S7; Validated; Region: PRK05302 698758000484 elongation factor G; Reviewed; Region: PRK00007 698758000485 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 698758000486 G1 box; other site 698758000487 putative GEF interaction site [polypeptide binding]; other site 698758000488 GTP/Mg2+ binding site [chemical binding]; other site 698758000489 Switch I region; other site 698758000490 G2 box; other site 698758000491 G3 box; other site 698758000492 Switch II region; other site 698758000493 G4 box; other site 698758000494 G5 box; other site 698758000495 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 698758000496 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698758000497 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698758000498 elongation factor Tu; Reviewed; Region: PRK00049 698758000499 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698758000500 G1 box; other site 698758000501 GEF interaction site [polypeptide binding]; other site 698758000502 GTP/Mg2+ binding site [chemical binding]; other site 698758000503 Switch I region; other site 698758000504 G2 box; other site 698758000505 G3 box; other site 698758000506 Switch II region; other site 698758000507 G4 box; other site 698758000508 G5 box; other site 698758000509 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698758000510 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698758000511 Antibiotic Binding Site [chemical binding]; other site 698758000512 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 698758000513 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 698758000514 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 698758000515 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 698758000516 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 698758000517 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 698758000518 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 698758000519 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 698758000520 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 698758000521 putative translocon binding site; other site 698758000522 protein-rRNA interface [nucleotide binding]; other site 698758000523 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 698758000524 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 698758000525 G-X-X-G motif; other site 698758000526 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 698758000527 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 698758000528 23S rRNA interface [nucleotide binding]; other site 698758000529 5S rRNA interface [nucleotide binding]; other site 698758000530 putative antibiotic binding site [chemical binding]; other site 698758000531 L25 interface [polypeptide binding]; other site 698758000532 L27 interface [polypeptide binding]; other site 698758000533 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 698758000534 23S rRNA interface [nucleotide binding]; other site 698758000535 putative translocon interaction site; other site 698758000536 signal recognition particle (SRP54) interaction site; other site 698758000537 L23 interface [polypeptide binding]; other site 698758000538 trigger factor interaction site; other site 698758000539 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 698758000540 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698758000541 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698758000542 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698758000543 RNA binding site [nucleotide binding]; other site 698758000544 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698758000545 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698758000546 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698758000547 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 698758000548 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 698758000549 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 698758000550 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698758000551 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698758000552 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 698758000553 5S rRNA interface [nucleotide binding]; other site 698758000554 L27 interface [polypeptide binding]; other site 698758000555 23S rRNA interface [nucleotide binding]; other site 698758000556 L5 interface [polypeptide binding]; other site 698758000557 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 698758000558 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 698758000559 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 698758000560 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 698758000561 23S rRNA binding site [nucleotide binding]; other site 698758000562 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 698758000563 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 698758000564 SecY translocase; Region: SecY; pfam00344 698758000565 adenylate kinase; Reviewed; Region: adk; PRK00279 698758000566 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 698758000567 AMP-binding site [chemical binding]; other site 698758000568 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 698758000569 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 698758000570 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 698758000571 rRNA binding site [nucleotide binding]; other site 698758000572 predicted 30S ribosome binding site; other site 698758000573 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 698758000574 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 698758000575 30S ribosomal protein S13; Region: bact_S13; TIGR03631 698758000576 30S ribosomal protein S11; Validated; Region: PRK05309 698758000577 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 698758000578 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 698758000579 alphaNTD - beta interaction site [polypeptide binding]; other site 698758000580 alphaNTD homodimer interface [polypeptide binding]; other site 698758000581 alphaNTD - beta' interaction site [polypeptide binding]; other site 698758000582 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698758000583 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 698758000584 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 698758000585 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698758000586 Walker A/P-loop; other site 698758000587 ATP binding site [chemical binding]; other site 698758000588 Q-loop/lid; other site 698758000589 ABC transporter signature motif; other site 698758000590 Walker B; other site 698758000591 D-loop; other site 698758000592 H-loop/switch region; other site 698758000593 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 698758000594 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698758000595 Walker A/P-loop; other site 698758000596 ATP binding site [chemical binding]; other site 698758000597 Q-loop/lid; other site 698758000598 ABC transporter signature motif; other site 698758000599 Walker B; other site 698758000600 D-loop; other site 698758000601 H-loop/switch region; other site 698758000602 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698758000603 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 698758000604 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 698758000605 dimerization interface 3.5A [polypeptide binding]; other site 698758000606 active site 698758000607 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 698758000608 23S rRNA interface [nucleotide binding]; other site 698758000609 L3 interface [polypeptide binding]; other site 698758000610 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 698758000611 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698758000612 active site 698758000613 catalytic residues [active] 698758000614 DNA binding site [nucleotide binding] 698758000615 Int/Topo IB signature motif; other site 698758000616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 698758000617 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698758000618 dimerization interface [polypeptide binding]; other site 698758000619 putative DNA binding site [nucleotide binding]; other site 698758000620 putative Zn2+ binding site [ion binding]; other site 698758000621 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698758000622 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698758000623 metal-binding site [ion binding] 698758000624 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698758000625 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698758000626 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698758000627 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 698758000628 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698758000629 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698758000630 FtsX-like permease family; Region: FtsX; pfam02687 698758000631 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698758000632 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698758000633 Walker A/P-loop; other site 698758000634 ATP binding site [chemical binding]; other site 698758000635 Q-loop/lid; other site 698758000636 ABC transporter signature motif; other site 698758000637 Walker B; other site 698758000638 D-loop; other site 698758000639 H-loop/switch region; other site 698758000640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698758000641 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698758000642 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698758000643 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 698758000644 YusW-like protein; Region: YusW; pfam14039 698758000645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698758000646 Coenzyme A binding pocket [chemical binding]; other site 698758000647 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 698758000648 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 698758000649 catalytic residues [active] 698758000650 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 698758000651 Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546 698758000652 dinuclear metal binding motif [ion binding]; other site 698758000653 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 698758000654 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698758000655 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698758000656 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698758000657 active site 698758000658 metal binding site [ion binding]; metal-binding site 698758000659 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 698758000660 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 698758000661 Walker A motif; other site 698758000662 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 698758000663 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 698758000664 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698758000665 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 698758000666 Int/Topo IB signature motif; other site 698758000667 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698758000668 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698758000669 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698758000670 non-specific DNA binding site [nucleotide binding]; other site 698758000671 salt bridge; other site 698758000672 sequence-specific DNA binding site [nucleotide binding]; other site 698758000673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 698758000674 non-specific DNA binding site [nucleotide binding]; other site 698758000675 salt bridge; other site 698758000676 sequence-specific DNA binding site [nucleotide binding]; other site 698758000677 Helix-turn-helix domain; Region: HTH_17; cl17695 698758000678 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The...; Region: SANT; cl17250 698758000679 glyceraldehyde-3-phosphate dehydrogenase B; Region: PLN02237 698758000680 Prophage antirepressor [Transcription]; Region: COG3617 698758000681 BRO family, N-terminal domain; Region: Bro-N; smart01040 698758000682 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 698758000683 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 698758000684 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 698758000685 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698758000686 active site 698758000687 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698758000688 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698758000689 dimer interface [polypeptide binding]; other site 698758000690 ssDNA binding site [nucleotide binding]; other site 698758000691 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698758000692 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540 698758000693 putative metal binding site [ion binding]; other site 698758000694 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 698758000695 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698758000696 active site 698758000697 Phage terminase, small subunit; Region: Terminase_4; cl01525 698758000698 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 698758000699 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 698758000700 Phage-related protein [Function unknown]; Region: COG4695; cl01923 698758000701 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 698758000702 oligomer interface [polypeptide binding]; other site 698758000703 active site residues [active] 698758000704 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 698758000705 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 698758000706 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 698758000707 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 698758000708 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 698758000709 Phage tail protein; Region: Sipho_tail; pfam05709 698758000710 Phage tail protein; Region: Sipho_tail; cl17486 698758000711 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 698758000712 Holin family; Region: Phage_holin_4; cl01989 698758000713 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698758000714 Peptidase family M23; Region: Peptidase_M23; pfam01551 698758000715 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698758000716 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698758000717 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 698758000718 putative metal binding site; other site 698758000719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698758000720 binding surface 698758000721 TPR motif; other site 698758000722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698758000723 binding surface 698758000724 TPR motif; other site 698758000725 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 698758000726 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 698758000727 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698758000728 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 698758000729 putative metal binding site; other site 698758000730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698758000731 binding surface 698758000732 TPR motif; other site 698758000733 Uncharacterized conserved protein [Function unknown]; Region: COG1624 698758000734 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 698758000735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 698758000736 YbbR-like protein; Region: YbbR; pfam07949 698758000737 YbbR-like protein; Region: YbbR; pfam07949 698758000738 YbbR-like protein; Region: YbbR; pfam07949 698758000739 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 698758000740 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 698758000741 active site 698758000742 substrate binding site [chemical binding]; other site 698758000743 metal binding site [ion binding]; metal-binding site 698758000744 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 698758000745 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 698758000746 Chromate transporter; Region: Chromate_transp; pfam02417 698758000747 Tubby C 2; Region: Tub_2; cl02043 698758000748 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 698758000749 Predicted membrane protein [Function unknown]; Region: COG4684 698758000750 hypothetical protein; Provisional; Region: PRK10578 698758000751 UPF0126 domain; Region: UPF0126; pfam03458 698758000752 UPF0126 domain; Region: UPF0126; pfam03458 698758000753 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698758000754 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 698758000755 metal binding site [ion binding]; metal-binding site 698758000756 dimer interface [polypeptide binding]; other site 698758000757 potential frameshift: common BLAST hit: gi|296505406|ref|YP_003667106.1| transcriptional activator TipA 698758000758 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 698758000759 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 698758000760 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 698758000761 DNA binding residues [nucleotide binding] 698758000762 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 698758000763 putative active site [active] 698758000764 GIY-YIG motif/motif A; other site 698758000765 putative metal binding site [ion binding]; other site 698758000766 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 698758000767 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 698758000768 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 698758000769 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 698758000770 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 698758000771 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 698758000772 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698758000773 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698758000774 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 698758000775 phosphopentomutase; Provisional; Region: PRK05362 698758000776 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 698758000777 purine nucleoside phosphorylase; Provisional; Region: PRK08202 698758000778 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 698758000779 active site 698758000780 catalytic motif [active] 698758000781 Zn binding site [ion binding]; other site 698758000782 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698758000783 intersubunit interface [polypeptide binding]; other site 698758000784 active site 698758000785 catalytic residue [active] 698758000786 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 698758000787 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 698758000788 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 698758000789 Response regulator receiver domain; Region: Response_reg; pfam00072 698758000790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758000791 active site 698758000792 phosphorylation site [posttranslational modification] 698758000793 intermolecular recognition site; other site 698758000794 dimerization interface [polypeptide binding]; other site 698758000795 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698758000796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758000797 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 698758000798 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 698758000799 inhibitor binding site; inhibition site 698758000800 active site 698758000801 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 698758000802 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 698758000803 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 698758000804 Predicted integral membrane protein [Function unknown]; Region: COG5578 698758000805 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 698758000806 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698758000807 dimerization interface [polypeptide binding]; other site 698758000808 Histidine kinase; Region: His_kinase; pfam06580 698758000809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758000810 ATP binding site [chemical binding]; other site 698758000811 Mg2+ binding site [ion binding]; other site 698758000812 G-X-G motif; other site 698758000813 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698758000814 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 698758000815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758000816 dimer interface [polypeptide binding]; other site 698758000817 conserved gate region; other site 698758000818 ABC-ATPase subunit interface; other site 698758000819 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698758000820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758000821 dimer interface [polypeptide binding]; other site 698758000822 ABC-ATPase subunit interface; other site 698758000823 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 698758000824 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 698758000825 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 698758000826 mannonate dehydratase; Provisional; Region: PRK03906 698758000827 mannonate dehydratase; Region: uxuA; TIGR00695 698758000828 D-mannonate oxidoreductase; Provisional; Region: PRK08277 698758000829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698758000830 NAD(P) binding site [chemical binding]; other site 698758000831 active site 698758000832 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 698758000833 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 698758000834 active site 698758000835 intersubunit interface [polypeptide binding]; other site 698758000836 catalytic residue [active] 698758000837 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698758000838 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 698758000839 substrate binding site [chemical binding]; other site 698758000840 ATP binding site [chemical binding]; other site 698758000841 Glucuronate isomerase; Region: UxaC; pfam02614 698758000842 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 698758000843 xylose isomerase; Provisional; Region: PRK05474 698758000844 xylose isomerase; Region: xylose_isom_A; TIGR02630 698758000845 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 698758000846 N- and C-terminal domain interface [polypeptide binding]; other site 698758000847 D-xylulose kinase; Region: XylB; TIGR01312 698758000848 active site 698758000849 MgATP binding site [chemical binding]; other site 698758000850 catalytic site [active] 698758000851 metal binding site [ion binding]; metal-binding site 698758000852 xylulose binding site [chemical binding]; other site 698758000853 homodimer interface [polypeptide binding]; other site 698758000854 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 698758000855 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698758000856 dimer interface [polypeptide binding]; other site 698758000857 substrate binding site [chemical binding]; other site 698758000858 ATP binding site [chemical binding]; other site 698758000859 mevalonate kinase; Region: mevalon_kin; TIGR00549 698758000860 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698758000861 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 698758000862 diphosphomevalonate decarboxylase; Region: PLN02407 698758000863 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 698758000864 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698758000865 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 698758000866 NAD(P) binding site [chemical binding]; other site 698758000867 catalytic residues [active] 698758000868 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 698758000869 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698758000870 Zn binding site [ion binding]; other site 698758000871 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 698758000872 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698758000873 Zn binding site [ion binding]; other site 698758000874 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698758000875 Histidine kinase; Region: HisKA_3; pfam07730 698758000876 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698758000877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758000878 active site 698758000879 phosphorylation site [posttranslational modification] 698758000880 intermolecular recognition site; other site 698758000881 dimerization interface [polypeptide binding]; other site 698758000882 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698758000883 DNA binding residues [nucleotide binding] 698758000884 dimerization interface [polypeptide binding]; other site 698758000885 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698758000886 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758000887 Walker A/P-loop; other site 698758000888 ATP binding site [chemical binding]; other site 698758000889 Q-loop/lid; other site 698758000890 ABC transporter signature motif; other site 698758000891 Walker B; other site 698758000892 D-loop; other site 698758000893 H-loop/switch region; other site 698758000894 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698758000895 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698758000896 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 698758000897 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698758000898 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698758000899 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698758000900 nucleotide binding site [chemical binding]; other site 698758000901 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 698758000902 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 698758000903 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 698758000904 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698758000905 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698758000906 peptidase T; Region: peptidase-T; TIGR01882 698758000907 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 698758000908 metal binding site [ion binding]; metal-binding site 698758000909 dimer interface [polypeptide binding]; other site 698758000910 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 698758000911 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 698758000912 homotetramer interface [polypeptide binding]; other site 698758000913 FMN binding site [chemical binding]; other site 698758000914 homodimer contacts [polypeptide binding]; other site 698758000915 putative active site [active] 698758000916 putative substrate binding site [chemical binding]; other site 698758000917 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 698758000918 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698758000919 zinc binding site [ion binding]; other site 698758000920 putative ligand binding site [chemical binding]; other site 698758000921 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698758000922 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 698758000923 TM-ABC transporter signature motif; other site 698758000924 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 698758000925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758000926 Walker A/P-loop; other site 698758000927 ATP binding site [chemical binding]; other site 698758000928 Q-loop/lid; other site 698758000929 ABC transporter signature motif; other site 698758000930 Walker B; other site 698758000931 D-loop; other site 698758000932 H-loop/switch region; other site 698758000933 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698758000934 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698758000935 Walker A/P-loop; other site 698758000936 ATP binding site [chemical binding]; other site 698758000937 Q-loop/lid; other site 698758000938 ABC transporter signature motif; other site 698758000939 Walker B; other site 698758000940 D-loop; other site 698758000941 H-loop/switch region; other site 698758000942 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 698758000943 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 698758000944 putative catalytic cysteine [active] 698758000945 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 698758000946 putative active site [active] 698758000947 metal binding site [ion binding]; metal-binding site 698758000948 Pyruvate formate lyase 1; Region: PFL1; cd01678 698758000949 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 698758000950 coenzyme A binding site [chemical binding]; other site 698758000951 active site 698758000952 catalytic residues [active] 698758000953 glycine loop; other site 698758000954 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 698758000955 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698758000956 FeS/SAM binding site; other site 698758000957 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 698758000958 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 698758000959 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 698758000960 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698758000961 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698758000962 Catalytic site [active] 698758000963 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698758000964 dimer interface [polypeptide binding]; other site 698758000965 substrate binding site [chemical binding]; other site 698758000966 ATP binding site [chemical binding]; other site 698758000967 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 698758000968 substrate binding site [chemical binding]; other site 698758000969 multimerization interface [polypeptide binding]; other site 698758000970 ATP binding site [chemical binding]; other site 698758000971 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698758000972 thiamine phosphate binding site [chemical binding]; other site 698758000973 active site 698758000974 pyrophosphate binding site [ion binding]; other site 698758000975 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 698758000976 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698758000977 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 698758000978 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 698758000979 ornithine carbamoyltransferase; Provisional; Region: PRK00779 698758000980 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698758000981 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698758000982 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 698758000983 FAD binding domain; Region: FAD_binding_4; pfam01565 698758000984 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 698758000985 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 698758000986 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 698758000987 active site residue [active] 698758000988 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 698758000989 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698758000990 Coenzyme A binding pocket [chemical binding]; other site 698758000991 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698758000992 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698758000993 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698758000994 protein binding site [polypeptide binding]; other site 698758000995 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698758000996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758000997 active site 698758000998 phosphorylation site [posttranslational modification] 698758000999 intermolecular recognition site; other site 698758001000 dimerization interface [polypeptide binding]; other site 698758001001 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698758001002 DNA binding site [nucleotide binding] 698758001003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698758001004 HAMP domain; Region: HAMP; pfam00672 698758001005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698758001006 dimer interface [polypeptide binding]; other site 698758001007 phosphorylation site [posttranslational modification] 698758001008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758001009 ATP binding site [chemical binding]; other site 698758001010 Mg2+ binding site [ion binding]; other site 698758001011 G-X-G motif; other site 698758001012 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 698758001013 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 698758001014 G1 box; other site 698758001015 putative GEF interaction site [polypeptide binding]; other site 698758001016 GTP/Mg2+ binding site [chemical binding]; other site 698758001017 Switch I region; other site 698758001018 G2 box; other site 698758001019 G3 box; other site 698758001020 Switch II region; other site 698758001021 G4 box; other site 698758001022 G5 box; other site 698758001023 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 698758001024 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 698758001025 PBP superfamily domain; Region: PBP_like_2; cl17296 698758001026 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 698758001027 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 698758001028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758001029 dimer interface [polypeptide binding]; other site 698758001030 conserved gate region; other site 698758001031 putative PBP binding loops; other site 698758001032 ABC-ATPase subunit interface; other site 698758001033 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 698758001034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758001035 dimer interface [polypeptide binding]; other site 698758001036 conserved gate region; other site 698758001037 putative PBP binding loops; other site 698758001038 ABC-ATPase subunit interface; other site 698758001039 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 698758001040 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 698758001041 Walker A/P-loop; other site 698758001042 ATP binding site [chemical binding]; other site 698758001043 Q-loop/lid; other site 698758001044 ABC transporter signature motif; other site 698758001045 Walker B; other site 698758001046 D-loop; other site 698758001047 H-loop/switch region; other site 698758001048 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698758001049 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 698758001050 FtsX-like permease family; Region: FtsX; pfam02687 698758001051 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698758001052 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698758001053 Walker A/P-loop; other site 698758001054 ATP binding site [chemical binding]; other site 698758001055 Q-loop/lid; other site 698758001056 ABC transporter signature motif; other site 698758001057 Walker B; other site 698758001058 D-loop; other site 698758001059 H-loop/switch region; other site 698758001060 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698758001061 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698758001062 Zn2+ binding site [ion binding]; other site 698758001063 Mg2+ binding site [ion binding]; other site 698758001064 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 698758001065 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 698758001066 putative active site [active] 698758001067 putative metal binding site [ion binding]; other site 698758001068 Domain of unknown function (DUF368); Region: DUF368; pfam04018 698758001069 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 698758001070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698758001071 Coenzyme A binding pocket [chemical binding]; other site 698758001072 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698758001073 MarR family; Region: MarR; pfam01047 698758001074 MarR family; Region: MarR_2; cl17246 698758001075 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698758001076 catalytic residues [active] 698758001077 YppG-like protein; Region: YppG; pfam14179 698758001078 Esterase/lipase [General function prediction only]; Region: COG1647 698758001079 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 698758001080 catalytic site [active] 698758001081 EDD domain protein, DegV family; Region: DegV; TIGR00762 698758001082 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698758001083 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698758001084 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698758001085 ATP binding site [chemical binding]; other site 698758001086 Mg++ binding site [ion binding]; other site 698758001087 motif III; other site 698758001088 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698758001089 nucleotide binding region [chemical binding]; other site 698758001090 ATP-binding site [chemical binding]; other site 698758001091 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698758001092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698758001093 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698758001094 Rhomboid family; Region: Rhomboid; pfam01694 698758001095 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 698758001096 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 698758001097 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 698758001098 putative substrate binding site [chemical binding]; other site 698758001099 putative ATP binding site [chemical binding]; other site 698758001100 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 698758001101 alanine racemase; Reviewed; Region: alr; PRK00053 698758001102 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698758001103 active site 698758001104 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698758001105 dimer interface [polypeptide binding]; other site 698758001106 substrate binding site [chemical binding]; other site 698758001107 catalytic residues [active] 698758001108 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 698758001109 PemK-like protein; Region: PemK; pfam02452 698758001110 Rsbr N terminal; Region: Rsbr_N; pfam08678 698758001111 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 698758001112 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 698758001113 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 698758001114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758001115 ATP binding site [chemical binding]; other site 698758001116 Mg2+ binding site [ion binding]; other site 698758001117 G-X-G motif; other site 698758001118 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 698758001119 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 698758001120 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 698758001121 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 698758001122 anti sigma factor interaction site; other site 698758001123 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 698758001124 regulatory phosphorylation site [posttranslational modification]; other site 698758001125 serine-protein kinase RsbW; Provisional; Region: PRK04069 698758001126 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 698758001127 ATP binding site [chemical binding]; other site 698758001128 Mg2+ binding site [ion binding]; other site 698758001129 G-X-G motif; other site 698758001130 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 698758001131 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698758001132 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698758001133 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698758001134 DNA binding residues [nucleotide binding] 698758001135 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 698758001136 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 698758001137 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 698758001138 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 698758001139 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 698758001140 RNA binding site [nucleotide binding]; other site 698758001141 carbamate kinase; Reviewed; Region: PRK12686 698758001142 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 698758001143 putative substrate binding site [chemical binding]; other site 698758001144 nucleotide binding site [chemical binding]; other site 698758001145 nucleotide binding site [chemical binding]; other site 698758001146 homodimer interface [polypeptide binding]; other site 698758001147 hypothetical protein; Provisional; Region: PRK04351 698758001148 SprT homologues; Region: SprT; cl01182 698758001149 thiamine monophosphate kinase; Provisional; Region: PRK05731 698758001150 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 698758001151 ATP binding site [chemical binding]; other site 698758001152 dimerization interface [polypeptide binding]; other site 698758001153 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 698758001154 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 698758001155 Glycoprotease family; Region: Peptidase_M22; pfam00814 698758001156 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 698758001157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698758001158 Coenzyme A binding pocket [chemical binding]; other site 698758001159 UGMP family protein; Validated; Region: PRK09604 698758001160 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 698758001161 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698758001162 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698758001163 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698758001164 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698758001165 ABC transporter; Region: ABC_tran_2; pfam12848 698758001166 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698758001167 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 698758001168 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 698758001169 CoA binding domain; Region: CoA_binding; pfam02629 698758001170 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 698758001171 CAAX protease self-immunity; Region: Abi; pfam02517 698758001172 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698758001173 oligomerisation interface [polypeptide binding]; other site 698758001174 mobile loop; other site 698758001175 roof hairpin; other site 698758001176 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698758001177 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698758001178 ring oligomerisation interface [polypeptide binding]; other site 698758001179 ATP/Mg binding site [chemical binding]; other site 698758001180 stacking interactions; other site 698758001181 hinge regions; other site 698758001182 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698758001183 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698758001184 Integrase core domain; Region: rve; pfam00665 698758001185 Response regulator receiver domain; Region: Response_reg; pfam00072 698758001186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758001187 active site 698758001188 phosphorylation site [posttranslational modification] 698758001189 intermolecular recognition site; other site 698758001190 dimerization interface [polypeptide binding]; other site 698758001191 histidinol-phosphatase; Provisional; Region: PRK07328 698758001192 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 698758001193 active site 698758001194 dimer interface [polypeptide binding]; other site 698758001195 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 698758001196 Amidohydrolase; Region: Amidohydro_2; pfam04909 698758001197 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 698758001198 putative active site [active] 698758001199 nucleotide binding site [chemical binding]; other site 698758001200 nudix motif; other site 698758001201 putative metal binding site [ion binding]; other site 698758001202 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698758001203 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698758001204 active site 698758001205 catalytic tetrad [active] 698758001206 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698758001207 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698758001208 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698758001209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758001210 dimer interface [polypeptide binding]; other site 698758001211 conserved gate region; other site 698758001212 putative PBP binding loops; other site 698758001213 ABC-ATPase subunit interface; other site 698758001214 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698758001215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758001216 dimer interface [polypeptide binding]; other site 698758001217 conserved gate region; other site 698758001218 putative PBP binding loops; other site 698758001219 ABC-ATPase subunit interface; other site 698758001220 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698758001221 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698758001222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758001223 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698758001224 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698758001225 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698758001226 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 698758001227 conserved cys residue [active] 698758001228 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698758001229 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698758001230 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698758001231 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698758001232 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 698758001233 DNA interaction; other site 698758001234 Metal-binding active site; metal-binding site 698758001235 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 698758001236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698758001237 PAS domain; Region: PAS_9; pfam13426 698758001238 putative active site [active] 698758001239 heme pocket [chemical binding]; other site 698758001240 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 698758001241 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 698758001242 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 698758001243 MoxR-like ATPases [General function prediction only]; Region: COG0714 698758001244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758001245 Walker A motif; other site 698758001246 ATP binding site [chemical binding]; other site 698758001247 Walker B motif; other site 698758001248 arginine finger; other site 698758001249 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 698758001250 Protein of unknown function DUF58; Region: DUF58; pfam01882 698758001251 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 698758001252 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 698758001253 GMP synthase; Reviewed; Region: guaA; PRK00074 698758001254 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 698758001255 conserved cys residue [active] 698758001256 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 698758001257 ATP Binding subdomain [chemical binding]; other site 698758001258 Ligand Binding sites [chemical binding]; other site 698758001259 Dimerization subdomain; other site 698758001260 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 698758001261 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698758001262 active site 698758001263 metal binding site [ion binding]; metal-binding site 698758001264 homotetramer interface [polypeptide binding]; other site 698758001265 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698758001266 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698758001267 active site 698758001268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698758001269 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698758001270 NAD(P) binding site [chemical binding]; other site 698758001271 active site 698758001272 Protein of unknown function DUF72; Region: DUF72; pfam01904 698758001273 Transcriptional regulator PadR-like family; Region: PadR; cl17335 698758001274 Predicted transcriptional regulators [Transcription]; Region: COG1695 698758001275 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 698758001276 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 698758001277 A new structural DNA glycosylase; Region: AlkD_like; cd06561 698758001278 active site 698758001279 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 698758001280 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698758001281 active site 698758001282 phosphorylation site [posttranslational modification] 698758001283 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 698758001284 active site 698758001285 P-loop; other site 698758001286 phosphorylation site [posttranslational modification] 698758001287 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 698758001288 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 698758001289 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 698758001290 putative substrate binding site [chemical binding]; other site 698758001291 putative ATP binding site [chemical binding]; other site 698758001292 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698758001293 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 698758001294 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698758001295 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 698758001296 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 698758001297 putative ligand binding site [chemical binding]; other site 698758001298 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698758001299 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698758001300 Walker A/P-loop; other site 698758001301 ATP binding site [chemical binding]; other site 698758001302 Q-loop/lid; other site 698758001303 ABC transporter signature motif; other site 698758001304 Walker B; other site 698758001305 D-loop; other site 698758001306 H-loop/switch region; other site 698758001307 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698758001308 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 698758001309 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698758001310 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698758001311 TM-ABC transporter signature motif; other site 698758001312 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 698758001313 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698758001314 ligand binding site [chemical binding]; other site 698758001315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698758001316 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698758001317 dimerization interface [polypeptide binding]; other site 698758001318 Histidine kinase; Region: His_kinase; pfam06580 698758001319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758001320 ATP binding site [chemical binding]; other site 698758001321 Mg2+ binding site [ion binding]; other site 698758001322 G-X-G motif; other site 698758001323 Response regulator receiver domain; Region: Response_reg; pfam00072 698758001324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758001325 active site 698758001326 phosphorylation site [posttranslational modification] 698758001327 intermolecular recognition site; other site 698758001328 dimerization interface [polypeptide binding]; other site 698758001329 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698758001330 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758001331 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 698758001332 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 698758001333 putative ligand binding site [chemical binding]; other site 698758001334 CHASE3 domain; Region: CHASE3; cl05000 698758001335 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 698758001336 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698758001337 dimerization interface [polypeptide binding]; other site 698758001338 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698758001339 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698758001340 dimer interface [polypeptide binding]; other site 698758001341 putative CheW interface [polypeptide binding]; other site 698758001342 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 698758001343 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698758001344 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698758001345 Walker A/P-loop; other site 698758001346 ATP binding site [chemical binding]; other site 698758001347 Q-loop/lid; other site 698758001348 ABC transporter signature motif; other site 698758001349 Walker B; other site 698758001350 D-loop; other site 698758001351 H-loop/switch region; other site 698758001352 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 698758001353 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 698758001354 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698758001355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758001356 S-adenosylmethionine binding site [chemical binding]; other site 698758001357 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 698758001358 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698758001359 putative NAD(P) binding site [chemical binding]; other site 698758001360 catalytic Zn binding site [ion binding]; other site 698758001361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698758001362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698758001363 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698758001364 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698758001365 Walker A/P-loop; other site 698758001366 ATP binding site [chemical binding]; other site 698758001367 Q-loop/lid; other site 698758001368 ABC transporter signature motif; other site 698758001369 Walker B; other site 698758001370 D-loop; other site 698758001371 H-loop/switch region; other site 698758001372 FtsX-like permease family; Region: FtsX; pfam02687 698758001373 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698758001374 FtsX-like permease family; Region: FtsX; pfam02687 698758001375 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698758001376 NETI protein; Region: NETI; pfam14044 698758001377 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 698758001378 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 698758001379 ATP-grasp domain; Region: ATP-grasp; pfam02222 698758001380 adenylosuccinate lyase; Provisional; Region: PRK07492 698758001381 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 698758001382 tetramer interface [polypeptide binding]; other site 698758001383 active site 698758001384 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 698758001385 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 698758001386 ATP binding site [chemical binding]; other site 698758001387 active site 698758001388 substrate binding site [chemical binding]; other site 698758001389 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 698758001390 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 698758001391 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 698758001392 conserved cys residue [active] 698758001393 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 698758001394 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 698758001395 dimerization interface [polypeptide binding]; other site 698758001396 ATP binding site [chemical binding]; other site 698758001397 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 698758001398 dimerization interface [polypeptide binding]; other site 698758001399 ATP binding site [chemical binding]; other site 698758001400 amidophosphoribosyltransferase; Provisional; Region: PRK07631 698758001401 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 698758001402 active site 698758001403 tetramer interface [polypeptide binding]; other site 698758001404 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698758001405 active site 698758001406 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 698758001407 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 698758001408 dimerization interface [polypeptide binding]; other site 698758001409 putative ATP binding site [chemical binding]; other site 698758001410 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 698758001411 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698758001412 active site 698758001413 substrate binding site [chemical binding]; other site 698758001414 cosubstrate binding site; other site 698758001415 catalytic site [active] 698758001416 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 698758001417 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 698758001418 purine monophosphate binding site [chemical binding]; other site 698758001419 dimer interface [polypeptide binding]; other site 698758001420 putative catalytic residues [active] 698758001421 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 698758001422 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 698758001423 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 698758001424 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 698758001425 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 698758001426 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 698758001427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758001428 ABC transporter signature motif; other site 698758001429 Walker B; other site 698758001430 D-loop; other site 698758001431 H-loop/switch region; other site 698758001432 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698758001433 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698758001434 Walker A/P-loop; other site 698758001435 ATP binding site [chemical binding]; other site 698758001436 Q-loop/lid; other site 698758001437 ABC transporter signature motif; other site 698758001438 Walker B; other site 698758001439 D-loop; other site 698758001440 H-loop/switch region; other site 698758001441 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698758001442 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698758001443 glutaminase active site [active] 698758001444 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698758001445 dimer interface [polypeptide binding]; other site 698758001446 active site 698758001447 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698758001448 dimer interface [polypeptide binding]; other site 698758001449 active site 698758001450 glutamine synthetase, type I; Region: GlnA; TIGR00653 698758001451 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698758001452 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 698758001453 Trp repressor protein; Region: Trp_repressor; cl17266 698758001454 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698758001455 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698758001456 PcrB family; Region: PcrB; pfam01884 698758001457 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 698758001458 substrate binding site [chemical binding]; other site 698758001459 putative active site [active] 698758001460 dimer interface [polypeptide binding]; other site 698758001461 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 698758001462 Part of AAA domain; Region: AAA_19; pfam13245 698758001463 Family description; Region: UvrD_C_2; pfam13538 698758001464 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 698758001465 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 698758001466 nucleotide binding pocket [chemical binding]; other site 698758001467 K-X-D-G motif; other site 698758001468 catalytic site [active] 698758001469 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 698758001470 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 698758001471 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 698758001472 Dimer interface [polypeptide binding]; other site 698758001473 BRCT sequence motif; other site 698758001474 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 698758001475 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 698758001476 putative dimer interface [polypeptide binding]; other site 698758001477 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 698758001478 putative dimer interface [polypeptide binding]; other site 698758001479 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 698758001480 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698758001481 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 698758001482 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 698758001483 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 698758001484 GatB domain; Region: GatB_Yqey; smart00845 698758001485 putative lipid kinase; Reviewed; Region: PRK13337 698758001486 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 698758001487 TRAM domain; Region: TRAM; cl01282 698758001488 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698758001489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758001490 S-adenosylmethionine binding site [chemical binding]; other site 698758001491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698758001492 non-specific DNA binding site [nucleotide binding]; other site 698758001493 salt bridge; other site 698758001494 sequence-specific DNA binding site [nucleotide binding]; other site 698758001495 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 698758001496 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 698758001497 trimer interface [polypeptide binding]; other site 698758001498 active site 698758001499 substrate binding site [chemical binding]; other site 698758001500 CoA binding site [chemical binding]; other site 698758001501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758001502 S-adenosylmethionine binding site [chemical binding]; other site 698758001503 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 698758001504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698758001505 Transposase; Region: HTH_Tnp_1; cl17663 698758001506 putative transposase OrfB; Reviewed; Region: PHA02517 698758001507 HTH-like domain; Region: HTH_21; pfam13276 698758001508 Integrase core domain; Region: rve; pfam00665 698758001509 Integrase core domain; Region: rve_2; pfam13333 698758001510 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698758001511 dimerization interface [polypeptide binding]; other site 698758001512 putative DNA binding site [nucleotide binding]; other site 698758001513 putative Zn2+ binding site [ion binding]; other site 698758001514 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 698758001515 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 698758001516 arsenical-resistance protein; Region: acr3; TIGR00832 698758001517 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 698758001518 Low molecular weight phosphatase family; Region: LMWPc; cd00115 698758001519 active site 698758001520 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 698758001521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 698758001522 Integrase core domain; Region: rve; pfam00665 698758001523 transposase/IS protein; Provisional; Region: PRK09183 698758001524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758001525 Walker A motif; other site 698758001526 ATP binding site [chemical binding]; other site 698758001527 Walker B motif; other site 698758001528 arginine finger; other site 698758001529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 698758001530 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 698758001531 Probable transposase; Region: OrfB_IS605; pfam01385 698758001532 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 698758001533 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698758001534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758001535 active site 698758001536 phosphorylation site [posttranslational modification] 698758001537 intermolecular recognition site; other site 698758001538 dimerization interface [polypeptide binding]; other site 698758001539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698758001540 DNA binding site [nucleotide binding] 698758001541 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698758001542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758001543 Walker A/P-loop; other site 698758001544 ATP binding site [chemical binding]; other site 698758001545 Q-loop/lid; other site 698758001546 ABC transporter signature motif; other site 698758001547 Walker B; other site 698758001548 D-loop; other site 698758001549 H-loop/switch region; other site 698758001550 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698758001551 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698758001552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698758001553 dimer interface [polypeptide binding]; other site 698758001554 phosphorylation site [posttranslational modification] 698758001555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758001556 ATP binding site [chemical binding]; other site 698758001557 Mg2+ binding site [ion binding]; other site 698758001558 G-X-G motif; other site 698758001559 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698758001560 amidase catalytic site [active] 698758001561 Zn binding residues [ion binding]; other site 698758001562 substrate binding site [chemical binding]; other site 698758001563 Sporulation related domain; Region: SPOR; pfam05036 698758001564 potential frameshift: common BLAST hit: gi|374297886|ref|YP_005048077.1| site-specific recombinase, DNA invertase Pin 698758001565 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 698758001566 catalytic nucleophile [active] 698758001567 potential frameshift: common BLAST hit: gi|385779681|ref|YP_005688846.1| Resolvase domain-containing protein 698758001568 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 698758001569 Recombinase; Region: Recombinase; pfam07508 698758001570 Recombinase; Region: Recombinase; pfam07508 698758001571 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 698758001572 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698758001573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758001574 active site 698758001575 phosphorylation site [posttranslational modification] 698758001576 intermolecular recognition site; other site 698758001577 dimerization interface [polypeptide binding]; other site 698758001578 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698758001579 DNA binding site [nucleotide binding] 698758001580 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698758001581 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 698758001582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758001583 ATP binding site [chemical binding]; other site 698758001584 Mg2+ binding site [ion binding]; other site 698758001585 G-X-G motif; other site 698758001586 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698758001587 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698758001588 Walker A/P-loop; other site 698758001589 ATP binding site [chemical binding]; other site 698758001590 Q-loop/lid; other site 698758001591 ABC transporter signature motif; other site 698758001592 Walker B; other site 698758001593 D-loop; other site 698758001594 H-loop/switch region; other site 698758001595 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 698758001596 Integrase core domain; Region: rve_2; pfam13333 698758001597 HTH-like domain; Region: HTH_21; pfam13276 698758001598 Integrase core domain; Region: rve; pfam00665 698758001599 Putative transcription activator [Transcription]; Region: TenA; COG0819 698758001600 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698758001601 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 698758001602 Walker A/P-loop; other site 698758001603 ATP binding site [chemical binding]; other site 698758001604 Q-loop/lid; other site 698758001605 ABC transporter signature motif; other site 698758001606 Walker B; other site 698758001607 D-loop; other site 698758001608 H-loop/switch region; other site 698758001609 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698758001610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758001611 dimer interface [polypeptide binding]; other site 698758001612 conserved gate region; other site 698758001613 putative PBP binding loops; other site 698758001614 ABC-ATPase subunit interface; other site 698758001615 NMT1/THI5 like; Region: NMT1; pfam09084 698758001616 Integrase core domain; Region: rve_2; pfam13333 698758001617 potential frameshift: common BLAST hit: gi|15616006|ref|NP_244311.1| transposase 698758001618 Integrase core domain; Region: rve; pfam00665 698758001619 HTH-like domain; Region: HTH_21; pfam13276 698758001620 Transposase; Region: HTH_Tnp_1; cl17663 698758001621 Integrase core domain; Region: rve_3; cl15866 698758001622 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 698758001623 GIY-YIG motif/motif A; other site 698758001624 putative active site [active] 698758001625 putative metal binding site [ion binding]; other site 698758001626 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 698758001627 Uncharacterized conserved protein [Function unknown]; Region: COG1479 698758001628 Protein of unknown function DUF262; Region: DUF262; pfam03235 698758001629 Protein of unknown function DUF262; Region: DUF262; pfam03235 698758001630 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698758001631 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 698758001632 Carboxylesterase family; Region: COesterase; pfam00135 698758001633 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698758001634 substrate binding pocket [chemical binding]; other site 698758001635 catalytic triad [active] 698758001636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758001637 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698758001638 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758001639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 698758001640 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698758001641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758001642 active site 698758001643 phosphorylation site [posttranslational modification] 698758001644 intermolecular recognition site; other site 698758001645 dimerization interface [polypeptide binding]; other site 698758001646 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698758001647 DNA binding site [nucleotide binding] 698758001648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698758001649 HAMP domain; Region: HAMP; pfam00672 698758001650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698758001651 dimer interface [polypeptide binding]; other site 698758001652 phosphorylation site [posttranslational modification] 698758001653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 698758001654 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698758001655 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698758001656 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698758001657 DNA binding residues [nucleotide binding] 698758001658 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 698758001659 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 698758001660 putative ligand binding site [chemical binding]; other site 698758001661 putative NAD binding site [chemical binding]; other site 698758001662 catalytic site [active] 698758001663 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 698758001664 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 698758001665 active site 698758001666 Right handed beta helix region; Region: Beta_helix; pfam13229 698758001667 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698758001668 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 698758001669 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698758001670 MarR family; Region: MarR; pfam01047 698758001671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698758001672 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698758001673 putative substrate translocation pore; other site 698758001674 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 698758001675 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 698758001676 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 698758001677 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 698758001678 V-type ATP synthase subunit I; Validated; Region: PRK05771 698758001679 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 698758001680 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990 698758001681 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 698758001682 V-type ATP synthase subunit A; Provisional; Region: PRK04192 698758001683 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698758001684 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 698758001685 Walker A motif/ATP binding site; other site 698758001686 Walker B motif; other site 698758001687 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698758001688 V-type ATP synthase subunit B; Provisional; Region: PRK04196 698758001689 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698758001690 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 698758001691 Walker A motif homologous position; other site 698758001692 Walker B motif; other site 698758001693 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698758001694 ATP synthase subunit D; Region: ATP-synt_D; pfam01813 698758001695 Predicted membrane protein [Function unknown]; Region: COG2855 698758001696 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698758001697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698758001698 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698758001699 dimerization interface [polypeptide binding]; other site 698758001700 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 698758001701 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 698758001702 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 698758001703 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698758001704 FMN binding site [chemical binding]; other site 698758001705 active site 698758001706 catalytic residues [active] 698758001707 substrate binding site [chemical binding]; other site 698758001708 Predicted transcriptional regulators [Transcription]; Region: COG1733 698758001709 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698758001710 putative DNA binding site [nucleotide binding]; other site 698758001711 dimerization interface [polypeptide binding]; other site 698758001712 putative Zn2+ binding site [ion binding]; other site 698758001713 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 698758001714 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 698758001715 putative metal binding site [ion binding]; other site 698758001716 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698758001717 active site 698758001718 metal binding site [ion binding]; metal-binding site 698758001719 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 698758001720 active site 698758001721 putative substrate binding region [chemical binding]; other site 698758001722 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698758001723 MgtE intracellular N domain; Region: MgtE_N; pfam03448 698758001724 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698758001725 Divalent cation transporter; Region: MgtE; pfam01769 698758001726 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 698758001727 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698758001728 active site turn [active] 698758001729 phosphorylation site [posttranslational modification] 698758001730 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698758001731 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 698758001732 HPr interaction site; other site 698758001733 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698758001734 active site 698758001735 phosphorylation site [posttranslational modification] 698758001736 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 698758001737 beta-galactosidase; Region: BGL; TIGR03356 698758001738 Domain of unknown function (DUF303); Region: DUF303; pfam03629 698758001739 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 698758001740 Domain of unknown function (DUF303); Region: DUF303; pfam03629 698758001741 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 698758001742 Penicillinase repressor; Region: Pencillinase_R; pfam03965 698758001743 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698758001744 metal-binding site [ion binding] 698758001745 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698758001746 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698758001747 metal-binding site [ion binding] 698758001748 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698758001749 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698758001750 metal-binding site [ion binding] 698758001751 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698758001752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758001753 motif II; other site 698758001754 Domain of unknown function DUF21; Region: DUF21; pfam01595 698758001755 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 698758001756 Melibiase; Region: Melibiase; pfam02065 698758001757 potential frameshift: common BLAST hit: gi|152976012|ref|YP_001375529.1| integrase catalytic region 698758001758 Integrase core domain; Region: rve; pfam00665 698758001759 Integrase core domain; Region: rve_3; pfam13683 698758001760 HTH-like domain; Region: HTH_21; pfam13276 698758001761 Transposase; Region: HTH_Tnp_1; pfam01527 698758001762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698758001763 WYL domain; Region: WYL; pfam13280 698758001764 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 698758001765 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698758001766 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 698758001767 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 698758001768 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 698758001769 DNA binding residues [nucleotide binding] 698758001770 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 698758001771 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698758001772 putative N- and C-terminal domain interface [polypeptide binding]; other site 698758001773 putative active site [active] 698758001774 MgATP binding site [chemical binding]; other site 698758001775 catalytic site [active] 698758001776 metal binding site [ion binding]; metal-binding site 698758001777 putative carbohydrate binding site [chemical binding]; other site 698758001778 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698758001779 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 698758001780 NAD(P) binding site [chemical binding]; other site 698758001781 active site 698758001782 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 698758001783 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 698758001784 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 698758001785 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 698758001786 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 698758001787 metal binding site [ion binding]; metal-binding site 698758001788 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 698758001789 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698758001790 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698758001791 dimer interface [polypeptide binding]; other site 698758001792 putative CheW interface [polypeptide binding]; other site 698758001793 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698758001794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698758001795 Coenzyme A binding pocket [chemical binding]; other site 698758001796 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 698758001797 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 698758001798 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698758001799 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698758001800 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698758001801 MarR family; Region: MarR_2; pfam12802 698758001802 MarR family; Region: MarR_2; cl17246 698758001803 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698758001804 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698758001805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758001806 Walker A/P-loop; other site 698758001807 ATP binding site [chemical binding]; other site 698758001808 Q-loop/lid; other site 698758001809 ABC transporter signature motif; other site 698758001810 Walker B; other site 698758001811 D-loop; other site 698758001812 H-loop/switch region; other site 698758001813 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698758001814 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698758001815 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 698758001816 Walker A/P-loop; other site 698758001817 ATP binding site [chemical binding]; other site 698758001818 Q-loop/lid; other site 698758001819 ABC transporter signature motif; other site 698758001820 Walker B; other site 698758001821 D-loop; other site 698758001822 H-loop/switch region; other site 698758001823 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698758001824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698758001825 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698758001826 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 698758001827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698758001828 putative substrate translocation pore; other site 698758001829 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 698758001830 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 698758001831 MoxR-like ATPases [General function prediction only]; Region: COG0714 698758001832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758001833 Walker A motif; other site 698758001834 ATP binding site [chemical binding]; other site 698758001835 Walker B motif; other site 698758001836 arginine finger; other site 698758001837 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 698758001838 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698758001839 metal ion-dependent adhesion site (MIDAS); other site 698758001840 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 698758001841 RDD family; Region: RDD; pfam06271 698758001842 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 698758001843 hypothetical protein; Validated; Region: PRK00194 698758001844 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698758001845 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 698758001846 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 698758001847 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698758001848 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 698758001849 putative NAD(P) binding site [chemical binding]; other site 698758001850 catalytic Zn binding site [ion binding]; other site 698758001851 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 698758001852 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698758001853 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698758001854 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 698758001855 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758001856 active site 698758001857 motif I; other site 698758001858 motif II; other site 698758001859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758001860 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 698758001861 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 698758001862 HPr interaction site; other site 698758001863 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698758001864 active site 698758001865 phosphorylation site [posttranslational modification] 698758001866 rod shape-determining protein MreB; Provisional; Region: PRK13930 698758001867 MreB and similar proteins; Region: MreB_like; cd10225 698758001868 nucleotide binding site [chemical binding]; other site 698758001869 Mg binding site [ion binding]; other site 698758001870 putative protofilament interaction site [polypeptide binding]; other site 698758001871 RodZ interaction site [polypeptide binding]; other site 698758001872 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 698758001873 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698758001874 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698758001875 putative acyl-acceptor binding pocket; other site 698758001876 PAS domain; Region: PAS_9; pfam13426 698758001877 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698758001878 putative active site [active] 698758001879 heme pocket [chemical binding]; other site 698758001880 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698758001881 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698758001882 metal binding site [ion binding]; metal-binding site 698758001883 active site 698758001884 I-site; other site 698758001885 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698758001886 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 698758001887 Low molecular weight phosphatase family; Region: LMWPc; cd00115 698758001888 active site 698758001889 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 698758001890 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698758001891 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698758001892 substrate binding pocket [chemical binding]; other site 698758001893 membrane-bound complex binding site; other site 698758001894 hinge residues; other site 698758001895 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698758001896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758001897 dimer interface [polypeptide binding]; other site 698758001898 conserved gate region; other site 698758001899 putative PBP binding loops; other site 698758001900 ABC-ATPase subunit interface; other site 698758001901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698758001902 Helix-turn-helix domain; Region: HTH_28; pfam13518 698758001903 Helix-turn-helix domain; Region: HTH_28; pfam13518 698758001904 HTH-like domain; Region: HTH_21; pfam13276 698758001905 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698758001906 Integrase core domain; Region: rve; pfam00665 698758001907 Integrase core domain; Region: rve_2; pfam13333 698758001908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698758001909 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698758001910 putative substrate translocation pore; other site 698758001911 YfkD-like protein; Region: YfkD; pfam14167 698758001912 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698758001913 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698758001914 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 698758001915 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 698758001916 NodB motif; other site 698758001917 active site 698758001918 catalytic site [active] 698758001919 Cd binding site [ion binding]; other site 698758001920 polyphosphate kinase; Provisional; Region: PRK05443 698758001921 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 698758001922 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 698758001923 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 698758001924 putative domain interface [polypeptide binding]; other site 698758001925 putative active site [active] 698758001926 catalytic site [active] 698758001927 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 698758001928 putative domain interface [polypeptide binding]; other site 698758001929 putative active site [active] 698758001930 catalytic site [active] 698758001931 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698758001932 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698758001933 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 698758001934 TPR motif; other site 698758001935 TPR repeat; Region: TPR_11; pfam13414 698758001936 binding surface 698758001937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758001938 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 698758001939 Walker A motif; other site 698758001940 ATP binding site [chemical binding]; other site 698758001941 Walker B motif; other site 698758001942 arginine finger; other site 698758001943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758001944 Walker A motif; other site 698758001945 ATP binding site [chemical binding]; other site 698758001946 Walker B motif; other site 698758001947 arginine finger; other site 698758001948 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698758001949 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 698758001950 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698758001951 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698758001952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758001953 Walker A/P-loop; other site 698758001954 ATP binding site [chemical binding]; other site 698758001955 Q-loop/lid; other site 698758001956 ABC transporter signature motif; other site 698758001957 Walker B; other site 698758001958 D-loop; other site 698758001959 H-loop/switch region; other site 698758001960 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 698758001961 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 698758001962 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 698758001963 Predicted integral membrane protein [Function unknown]; Region: COG5658 698758001964 SdpI/YhfL protein family; Region: SdpI; pfam13630 698758001965 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698758001966 dimerization interface [polypeptide binding]; other site 698758001967 putative DNA binding site [nucleotide binding]; other site 698758001968 putative Zn2+ binding site [ion binding]; other site 698758001969 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698758001970 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698758001971 ABC transporter; Region: ABC_tran_2; pfam12848 698758001972 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698758001973 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 698758001974 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 698758001975 classical (c) SDRs; Region: SDR_c; cd05233 698758001976 NAD(P) binding site [chemical binding]; other site 698758001977 active site 698758001978 HAMP domain; Region: HAMP; pfam00672 698758001979 dimerization interface [polypeptide binding]; other site 698758001980 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698758001981 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698758001982 dimer interface [polypeptide binding]; other site 698758001983 putative CheW interface [polypeptide binding]; other site 698758001984 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 698758001985 Predicted transcriptional regulator [Transcription]; Region: COG2345 698758001986 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698758001987 putative DNA binding site [nucleotide binding]; other site 698758001988 putative Zn2+ binding site [ion binding]; other site 698758001989 RecX family; Region: RecX; cl00936 698758001990 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758001991 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698758001992 active site 698758001993 motif I; other site 698758001994 motif II; other site 698758001995 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 698758001996 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 698758001997 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 698758001998 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698758001999 minor groove reading motif; other site 698758002000 helix-hairpin-helix signature motif; other site 698758002001 substrate binding pocket [chemical binding]; other site 698758002002 active site 698758002003 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 698758002004 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 698758002005 DNA binding and oxoG recognition site [nucleotide binding] 698758002006 hypothetical protein; Provisional; Region: PRK13662 698758002007 Predicted membrane protein [Function unknown]; Region: COG4129 698758002008 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 698758002009 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 698758002010 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698758002011 NAD binding site [chemical binding]; other site 698758002012 ligand binding site [chemical binding]; other site 698758002013 catalytic site [active] 698758002014 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 698758002015 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698758002016 metal binding site 2 [ion binding]; metal-binding site 698758002017 putative DNA binding helix; other site 698758002018 metal binding site 1 [ion binding]; metal-binding site 698758002019 dimer interface [polypeptide binding]; other site 698758002020 structural Zn2+ binding site [ion binding]; other site 698758002021 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 698758002022 GIY-YIG motif/motif A; other site 698758002023 putative active site [active] 698758002024 putative metal binding site [ion binding]; other site 698758002025 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 698758002026 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 698758002027 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 698758002028 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698758002029 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698758002030 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698758002031 Walker A/P-loop; other site 698758002032 ATP binding site [chemical binding]; other site 698758002033 Q-loop/lid; other site 698758002034 ABC transporter signature motif; other site 698758002035 Walker B; other site 698758002036 D-loop; other site 698758002037 H-loop/switch region; other site 698758002038 Predicted membrane protein [Function unknown]; Region: COG1470 698758002039 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 698758002040 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 698758002041 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698758002042 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698758002043 DNA binding residues [nucleotide binding] 698758002044 Putative zinc-finger; Region: zf-HC2; pfam13490 698758002045 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 698758002046 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 698758002047 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 698758002048 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698758002049 Zn binding site [ion binding]; other site 698758002050 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 698758002051 Zn binding site [ion binding]; other site 698758002052 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 698758002053 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 698758002054 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698758002055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758002056 active site 698758002057 phosphorylation site [posttranslational modification] 698758002058 intermolecular recognition site; other site 698758002059 dimerization interface [polypeptide binding]; other site 698758002060 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698758002061 DNA binding site [nucleotide binding] 698758002062 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698758002063 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 698758002064 dimer interface [polypeptide binding]; other site 698758002065 phosphorylation site [posttranslational modification] 698758002066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758002067 ATP binding site [chemical binding]; other site 698758002068 Mg2+ binding site [ion binding]; other site 698758002069 G-X-G motif; other site 698758002070 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698758002071 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698758002072 Walker A/P-loop; other site 698758002073 ATP binding site [chemical binding]; other site 698758002074 Q-loop/lid; other site 698758002075 ABC transporter signature motif; other site 698758002076 Walker B; other site 698758002077 D-loop; other site 698758002078 H-loop/switch region; other site 698758002079 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698758002080 FtsX-like permease family; Region: FtsX; pfam02687 698758002081 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698758002082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758002083 active site 698758002084 phosphorylation site [posttranslational modification] 698758002085 intermolecular recognition site; other site 698758002086 dimerization interface [polypeptide binding]; other site 698758002087 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698758002088 DNA binding site [nucleotide binding] 698758002089 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698758002090 dimerization interface [polypeptide binding]; other site 698758002091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698758002092 dimer interface [polypeptide binding]; other site 698758002093 phosphorylation site [posttranslational modification] 698758002094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758002095 ATP binding site [chemical binding]; other site 698758002096 Mg2+ binding site [ion binding]; other site 698758002097 G-X-G motif; other site 698758002098 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 698758002099 FlaG protein; Region: FlaG; cl00591 698758002100 flagellar capping protein; Validated; Region: fliD; PRK07737 698758002101 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 698758002102 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 698758002103 flagellar protein FliS; Validated; Region: fliS; PRK05685 698758002104 Flagellar protein FliT; Region: FliT; cl05125 698758002105 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 698758002106 30S subunit binding site; other site 698758002107 MarR family; Region: MarR_2; pfam12802 698758002108 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698758002109 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698758002110 nucleotide binding site [chemical binding]; other site 698758002111 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698758002112 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 698758002113 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 698758002114 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698758002115 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 698758002116 DEAD/DEAH box helicase; Region: DEAD; pfam00270 698758002117 ATP binding site [chemical binding]; other site 698758002118 putative Mg++ binding site [ion binding]; other site 698758002119 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 698758002120 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698758002121 nucleotide binding region [chemical binding]; other site 698758002122 ATP-binding site [chemical binding]; other site 698758002123 SEC-C motif; Region: SEC-C; pfam02810 698758002124 peptide chain release factor 2; Validated; Region: prfB; PRK00578 698758002125 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698758002126 RF-1 domain; Region: RF-1; pfam00472 698758002127 Uncharacterized conserved protein [Function unknown]; Region: COG1284 698758002128 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 698758002129 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 698758002130 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 698758002131 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698758002132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758002133 Walker A/P-loop; other site 698758002134 ATP binding site [chemical binding]; other site 698758002135 Q-loop/lid; other site 698758002136 ABC transporter signature motif; other site 698758002137 Walker B; other site 698758002138 D-loop; other site 698758002139 H-loop/switch region; other site 698758002140 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 698758002141 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 698758002142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 698758002143 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698758002144 Peptidase family M23; Region: Peptidase_M23; pfam01551 698758002145 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 698758002146 C-terminal peptidase (prc); Region: prc; TIGR00225 698758002147 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 698758002148 protein binding site [polypeptide binding]; other site 698758002149 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 698758002150 Catalytic dyad [active] 698758002151 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698758002152 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698758002153 SWIM zinc finger; Region: SWIM; pfam04434 698758002154 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 698758002155 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 698758002156 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698758002157 ATP binding site [chemical binding]; other site 698758002158 putative Mg++ binding site [ion binding]; other site 698758002159 Class II histone deacetylase complex subunits 2 and 3; Region: HDA2-3; pfam11496 698758002160 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698758002161 nucleotide binding region [chemical binding]; other site 698758002162 ATP-binding site [chemical binding]; other site 698758002163 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 698758002164 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 698758002165 G1 box; other site 698758002166 putative GEF interaction site [polypeptide binding]; other site 698758002167 GTP/Mg2+ binding site [chemical binding]; other site 698758002168 Switch I region; other site 698758002169 G2 box; other site 698758002170 G3 box; other site 698758002171 Switch II region; other site 698758002172 G4 box; other site 698758002173 G5 box; other site 698758002174 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 698758002175 excinuclease ABC subunit B; Provisional; Region: PRK05298 698758002176 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698758002177 ATP binding site [chemical binding]; other site 698758002178 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698758002179 putative Mg++ binding site [ion binding]; other site 698758002180 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698758002181 nucleotide binding region [chemical binding]; other site 698758002182 ATP-binding site [chemical binding]; other site 698758002183 Ultra-violet resistance protein B; Region: UvrB; pfam12344 698758002184 UvrB/uvrC motif; Region: UVR; pfam02151 698758002185 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 698758002186 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698758002187 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698758002188 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 698758002189 PspC domain; Region: PspC; pfam04024 698758002190 Predicted membrane protein [Function unknown]; Region: COG1950 698758002191 aminodeoxychorismate synthase; Provisional; Region: PRK07508 698758002192 chorismate binding enzyme; Region: Chorismate_bind; cl10555 698758002193 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 698758002194 substrate-cofactor binding pocket; other site 698758002195 homodimer interface [polypeptide binding]; other site 698758002196 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698758002197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698758002198 catalytic residue [active] 698758002199 HPr kinase/phosphorylase; Provisional; Region: PRK05428 698758002200 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 698758002201 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 698758002202 Hpr binding site; other site 698758002203 active site 698758002204 homohexamer subunit interaction site [polypeptide binding]; other site 698758002205 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 698758002206 pyrophosphatase PpaX; Provisional; Region: PRK13288 698758002207 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758002208 motif II; other site 698758002209 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 698758002210 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 698758002211 trimer interface [polypeptide binding]; other site 698758002212 active site 698758002213 substrate binding site [chemical binding]; other site 698758002214 CoA binding site [chemical binding]; other site 698758002215 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698758002216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698758002217 binding surface 698758002218 TPR motif; other site 698758002219 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698758002220 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698758002221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698758002222 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698758002223 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698758002224 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698758002225 putative active site [active] 698758002226 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 698758002227 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 698758002228 NAD binding site [chemical binding]; other site 698758002229 sugar binding site [chemical binding]; other site 698758002230 divalent metal binding site [ion binding]; other site 698758002231 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698758002232 dimer interface [polypeptide binding]; other site 698758002233 phosphodiesterase; Provisional; Region: PRK12704 698758002234 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 698758002235 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 698758002236 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698758002237 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698758002238 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698758002239 metal-binding site [ion binding] 698758002240 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 698758002241 putative active site [active] 698758002242 nucleotide binding site [chemical binding]; other site 698758002243 nudix motif; other site 698758002244 putative metal binding site [ion binding]; other site 698758002245 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 698758002246 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 698758002247 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 698758002248 phosphate binding site [ion binding]; other site 698758002249 putative substrate binding pocket [chemical binding]; other site 698758002250 dimer interface [polypeptide binding]; other site 698758002251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 698758002252 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 698758002253 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698758002254 dimerization domain swap beta strand [polypeptide binding]; other site 698758002255 regulatory protein interface [polypeptide binding]; other site 698758002256 active site 698758002257 regulatory phosphorylation site [posttranslational modification]; other site 698758002258 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 698758002259 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 698758002260 Walker A/P-loop; other site 698758002261 ATP binding site [chemical binding]; other site 698758002262 Q-loop/lid; other site 698758002263 ABC transporter signature motif; other site 698758002264 Walker B; other site 698758002265 D-loop; other site 698758002266 H-loop/switch region; other site 698758002267 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698758002268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758002269 dimer interface [polypeptide binding]; other site 698758002270 conserved gate region; other site 698758002271 putative PBP binding loops; other site 698758002272 ABC-ATPase subunit interface; other site 698758002273 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 698758002274 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698758002275 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 698758002276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698758002277 FeS/SAM binding site; other site 698758002278 transcriptional antiterminator BglG; Provisional; Region: PRK09772 698758002279 CAT RNA binding domain; Region: CAT_RBD; smart01061 698758002280 PRD domain; Region: PRD; pfam00874 698758002281 PRD domain; Region: PRD; pfam00874 698758002282 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 698758002283 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698758002284 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698758002285 active site turn [active] 698758002286 phosphorylation site [posttranslational modification] 698758002287 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 698758002288 HPr interaction site; other site 698758002289 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698758002290 active site 698758002291 phosphorylation site [posttranslational modification] 698758002292 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 698758002293 potential frameshift: common BLAST hit: gi|15616548|ref|NP_244854.1| transposase 698758002294 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 698758002295 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 698758002296 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 698758002297 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 698758002298 putative active site [active] 698758002299 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698758002300 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698758002301 Walker A/P-loop; other site 698758002302 ATP binding site [chemical binding]; other site 698758002303 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 698758002304 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 698758002305 putative active site [active] 698758002306 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698758002307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758002308 Walker A/P-loop; other site 698758002309 ATP binding site [chemical binding]; other site 698758002310 Q-loop/lid; other site 698758002311 ABC transporter signature motif; other site 698758002312 Walker B; other site 698758002313 D-loop; other site 698758002314 H-loop/switch region; other site 698758002315 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 698758002316 HlyD family secretion protein; Region: HlyD_3; pfam13437 698758002317 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698758002318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758002319 active site 698758002320 phosphorylation site [posttranslational modification] 698758002321 intermolecular recognition site; other site 698758002322 dimerization interface [polypeptide binding]; other site 698758002323 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698758002324 DNA binding residues [nucleotide binding] 698758002325 dimerization interface [polypeptide binding]; other site 698758002326 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 698758002327 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 698758002328 Walker A/P-loop; other site 698758002329 ATP binding site [chemical binding]; other site 698758002330 Q-loop/lid; other site 698758002331 ABC transporter signature motif; other site 698758002332 Walker B; other site 698758002333 D-loop; other site 698758002334 H-loop/switch region; other site 698758002335 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 698758002336 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 698758002337 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698758002338 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698758002339 active site 698758002340 metal binding site [ion binding]; metal-binding site 698758002341 DNA binding site [nucleotide binding] 698758002342 Uncharacterized conserved protein [Function unknown]; Region: COG4717 698758002343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758002344 Walker A/P-loop; other site 698758002345 ATP binding site [chemical binding]; other site 698758002346 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 698758002347 generic binding surface I; other site 698758002348 generic binding surface II; other site 698758002349 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698758002350 Zn2+ binding site [ion binding]; other site 698758002351 Mg2+ binding site [ion binding]; other site 698758002352 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 698758002353 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698758002354 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 698758002355 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 698758002356 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 698758002357 HIT family signature motif; other site 698758002358 catalytic residue [active] 698758002359 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698758002360 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698758002361 Walker A/P-loop; other site 698758002362 ATP binding site [chemical binding]; other site 698758002363 Q-loop/lid; other site 698758002364 ABC transporter signature motif; other site 698758002365 Walker B; other site 698758002366 D-loop; other site 698758002367 H-loop/switch region; other site 698758002368 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 698758002369 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 698758002370 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698758002371 Histidine kinase; Region: HisKA_3; pfam07730 698758002372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758002373 ATP binding site [chemical binding]; other site 698758002374 Mg2+ binding site [ion binding]; other site 698758002375 G-X-G motif; other site 698758002376 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698758002377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758002378 active site 698758002379 phosphorylation site [posttranslational modification] 698758002380 intermolecular recognition site; other site 698758002381 dimerization interface [polypeptide binding]; other site 698758002382 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698758002383 DNA binding residues [nucleotide binding] 698758002384 dimerization interface [polypeptide binding]; other site 698758002385 Transglycosylase; Region: Transgly; pfam00912 698758002386 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 698758002387 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 698758002388 putative active site [active] 698758002389 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698758002390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758002391 Walker A/P-loop; other site 698758002392 ATP binding site [chemical binding]; other site 698758002393 Q-loop/lid; other site 698758002394 ABC transporter signature motif; other site 698758002395 Walker B; other site 698758002396 D-loop; other site 698758002397 H-loop/switch region; other site 698758002398 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 698758002399 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698758002400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 698758002401 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 698758002402 Walker A/P-loop; other site 698758002403 ATP binding site [chemical binding]; other site 698758002404 Q-loop/lid; other site 698758002405 ABC transporter signature motif; other site 698758002406 Walker B; other site 698758002407 D-loop; other site 698758002408 H-loop/switch region; other site 698758002409 Rhomboid family; Region: Rhomboid; pfam01694 698758002410 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698758002411 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698758002412 Walker A/P-loop; other site 698758002413 ATP binding site [chemical binding]; other site 698758002414 Q-loop/lid; other site 698758002415 ABC transporter signature motif; other site 698758002416 Walker B; other site 698758002417 D-loop; other site 698758002418 H-loop/switch region; other site 698758002419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758002420 Walker B; other site 698758002421 D-loop; other site 698758002422 H-loop/switch region; other site 698758002423 Right handed beta helix region; Region: Beta_helix; pfam13229 698758002424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698758002425 Transposase; Region: HTH_Tnp_1; pfam01527 698758002426 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 698758002427 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 698758002428 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 698758002429 substrate binding site [chemical binding]; other site 698758002430 active site 698758002431 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 698758002432 metal binding site [ion binding]; metal-binding site 698758002433 ligand binding site [chemical binding]; other site 698758002434 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 698758002435 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 698758002436 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 698758002437 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698758002438 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 698758002439 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 698758002440 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698758002441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698758002442 dimerization interface [polypeptide binding]; other site 698758002443 Histidine kinase; Region: His_kinase; pfam06580 698758002444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758002445 ATP binding site [chemical binding]; other site 698758002446 Mg2+ binding site [ion binding]; other site 698758002447 G-X-G motif; other site 698758002448 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 698758002449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758002450 active site 698758002451 phosphorylation site [posttranslational modification] 698758002452 intermolecular recognition site; other site 698758002453 dimerization interface [polypeptide binding]; other site 698758002454 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758002455 Protein of unknown function, DUF624; Region: DUF624; cl02369 698758002456 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 698758002457 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 698758002458 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 698758002459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758002460 dimer interface [polypeptide binding]; other site 698758002461 conserved gate region; other site 698758002462 ABC-ATPase subunit interface; other site 698758002463 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698758002464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758002465 dimer interface [polypeptide binding]; other site 698758002466 conserved gate region; other site 698758002467 ABC-ATPase subunit interface; other site 698758002468 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698758002469 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698758002470 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 698758002471 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 698758002472 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 698758002473 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 698758002474 putative alpha-glucosidase; Provisional; Region: PRK10658 698758002475 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 698758002476 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 698758002477 active site 698758002478 homotrimer interface [polypeptide binding]; other site 698758002479 catalytic site [active] 698758002480 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 698758002481 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 698758002482 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 698758002483 inhibitor binding site; inhibition site 698758002484 active site 698758002485 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 698758002486 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 698758002487 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 698758002488 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 698758002489 ComK protein; Region: ComK; cl11560 698758002490 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 698758002491 Uncharacterized conserved protein [Function unknown]; Region: COG0398 698758002492 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 698758002493 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 698758002494 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698758002495 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 698758002496 Part of AAA domain; Region: AAA_19; pfam13245 698758002497 Family description; Region: UvrD_C_2; pfam13538 698758002498 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698758002499 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698758002500 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698758002501 ABC-ATPase subunit interface; other site 698758002502 dimer interface [polypeptide binding]; other site 698758002503 putative PBP binding regions; other site 698758002504 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698758002505 ABC-ATPase subunit interface; other site 698758002506 dimer interface [polypeptide binding]; other site 698758002507 putative PBP binding regions; other site 698758002508 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 698758002509 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698758002510 Walker A/P-loop; other site 698758002511 ATP binding site [chemical binding]; other site 698758002512 Q-loop/lid; other site 698758002513 ABC transporter signature motif; other site 698758002514 Walker B; other site 698758002515 D-loop; other site 698758002516 H-loop/switch region; other site 698758002517 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 698758002518 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 698758002519 putative ligand binding residues [chemical binding]; other site 698758002520 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 698758002521 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 698758002522 Response regulator receiver domain; Region: Response_reg; pfam00072 698758002523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758002524 active site 698758002525 phosphorylation site [posttranslational modification] 698758002526 intermolecular recognition site; other site 698758002527 dimerization interface [polypeptide binding]; other site 698758002528 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698758002529 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698758002530 dimer interface [polypeptide binding]; other site 698758002531 putative CheW interface [polypeptide binding]; other site 698758002532 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 698758002533 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698758002534 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 698758002535 active site 698758002536 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 698758002537 active site 698758002538 Zn binding site [ion binding]; other site 698758002539 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698758002540 Ligand Binding Site [chemical binding]; other site 698758002541 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698758002542 metal binding site 2 [ion binding]; metal-binding site 698758002543 putative DNA binding helix; other site 698758002544 metal binding site 1 [ion binding]; metal-binding site 698758002545 dimer interface [polypeptide binding]; other site 698758002546 structural Zn2+ binding site [ion binding]; other site 698758002547 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698758002548 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698758002549 ABC-ATPase subunit interface; other site 698758002550 dimer interface [polypeptide binding]; other site 698758002551 putative PBP binding regions; other site 698758002552 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698758002553 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698758002554 Coat F domain; Region: Coat_F; pfam07875 698758002555 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 698758002556 ArsC family; Region: ArsC; pfam03960 698758002557 putative ArsC-like catalytic residues; other site 698758002558 putative TRX-like catalytic residues [active] 698758002559 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 698758002560 lipoyl attachment site [posttranslational modification]; other site 698758002561 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698758002562 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698758002563 catalytic residues [active] 698758002564 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 698758002565 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698758002566 Walker A/P-loop; other site 698758002567 ATP binding site [chemical binding]; other site 698758002568 Q-loop/lid; other site 698758002569 ABC transporter signature motif; other site 698758002570 Walker B; other site 698758002571 D-loop; other site 698758002572 H-loop/switch region; other site 698758002573 NIL domain; Region: NIL; pfam09383 698758002574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758002575 ABC-ATPase subunit interface; other site 698758002576 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698758002577 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698758002578 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 698758002579 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 698758002580 Walker A/P-loop; other site 698758002581 ATP binding site [chemical binding]; other site 698758002582 Q-loop/lid; other site 698758002583 ABC transporter signature motif; other site 698758002584 Walker B; other site 698758002585 D-loop; other site 698758002586 H-loop/switch region; other site 698758002587 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 698758002588 FeS assembly protein SufD; Region: sufD; TIGR01981 698758002589 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698758002590 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 698758002591 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698758002592 catalytic residue [active] 698758002593 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 698758002594 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 698758002595 trimerization site [polypeptide binding]; other site 698758002596 active site 698758002597 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 698758002598 FeS assembly protein SufB; Region: sufB; TIGR01980 698758002599 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 698758002600 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698758002601 Walker A/P-loop; other site 698758002602 ATP binding site [chemical binding]; other site 698758002603 Q-loop/lid; other site 698758002604 ABC transporter signature motif; other site 698758002605 D-loop; other site 698758002606 H-loop/switch region; other site 698758002607 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 698758002608 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 698758002609 active site 698758002610 metal binding site [ion binding]; metal-binding site 698758002611 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 698758002612 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 698758002613 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698758002614 Zn2+ binding site [ion binding]; other site 698758002615 Mg2+ binding site [ion binding]; other site 698758002616 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 698758002617 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 698758002618 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 698758002619 Uncharacterized conserved protein [Function unknown]; Region: COG4983 698758002620 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 698758002621 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698758002622 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 698758002623 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698758002624 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698758002625 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698758002626 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 698758002627 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698758002628 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698758002629 ATP binding site [chemical binding]; other site 698758002630 putative Mg++ binding site [ion binding]; other site 698758002631 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 698758002632 Transposase IS200 like; Region: Y1_Tnp; pfam01797 698758002633 Probable transposase; Region: OrfB_IS605; pfam01385 698758002634 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 698758002635 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 698758002636 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 698758002637 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 698758002638 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698758002639 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698758002640 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698758002641 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 698758002642 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 698758002643 THF binding site; other site 698758002644 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 698758002645 substrate binding site [chemical binding]; other site 698758002646 THF binding site; other site 698758002647 zinc-binding site [ion binding]; other site 698758002648 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698758002649 FAD binding site [chemical binding]; other site 698758002650 potential frameshift: common BLAST hit: gi|15613245|ref|NP_241548.1| cassette chromosome recombinase B1 698758002651 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 698758002652 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698758002653 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 698758002654 Na2 binding site [ion binding]; other site 698758002655 putative substrate binding site 1 [chemical binding]; other site 698758002656 Na binding site 1 [ion binding]; other site 698758002657 putative substrate binding site 2 [chemical binding]; other site 698758002658 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698758002659 Peptidase family M23; Region: Peptidase_M23; pfam01551 698758002660 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 698758002661 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 698758002662 tetramer interfaces [polypeptide binding]; other site 698758002663 binuclear metal-binding site [ion binding]; other site 698758002664 homoserine dehydrogenase; Provisional; Region: PRK06349 698758002665 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 698758002666 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 698758002667 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 698758002668 threonine synthase; Reviewed; Region: PRK06721 698758002669 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 698758002670 homodimer interface [polypeptide binding]; other site 698758002671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698758002672 catalytic residue [active] 698758002673 homoserine kinase; Provisional; Region: PRK01212 698758002674 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698758002675 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698758002676 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 698758002677 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 698758002678 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 698758002679 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698758002680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698758002681 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698758002682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698758002683 Divergent PAP2 family; Region: DUF212; pfam02681 698758002684 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 698758002685 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 698758002686 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 698758002687 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698758002688 dimerization domain swap beta strand [polypeptide binding]; other site 698758002689 regulatory protein interface [polypeptide binding]; other site 698758002690 active site 698758002691 regulatory phosphorylation site [posttranslational modification]; other site 698758002692 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 698758002693 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698758002694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698758002695 homodimer interface [polypeptide binding]; other site 698758002696 catalytic residue [active] 698758002697 general stress protein 13; Validated; Region: PRK08059 698758002698 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 698758002699 RNA binding site [nucleotide binding]; other site 698758002700 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 698758002701 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 698758002702 active site 698758002703 dimer interface [polypeptide binding]; other site 698758002704 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 698758002705 dimer interface [polypeptide binding]; other site 698758002706 active site 698758002707 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 698758002708 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 698758002709 oligomer interface [polypeptide binding]; other site 698758002710 active site 698758002711 metal binding site [ion binding]; metal-binding site 698758002712 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 698758002713 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 698758002714 active site 698758002715 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 698758002716 Ligand Binding Site [chemical binding]; other site 698758002717 Molecular Tunnel; other site 698758002718 Predicted membrane protein [Function unknown]; Region: COG3601 698758002719 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 698758002720 DNA polymerase IV; Reviewed; Region: PRK03103 698758002721 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698758002722 active site 698758002723 DNA binding site [nucleotide binding] 698758002724 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 698758002725 YolD-like protein; Region: YolD; pfam08863 698758002726 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 698758002727 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 698758002728 nudix motif; other site 698758002729 S-adenosylmethionine synthetase; Validated; Region: PRK05250 698758002730 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698758002731 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698758002732 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698758002733 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 698758002734 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698758002735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758002736 S-adenosylmethionine binding site [chemical binding]; other site 698758002737 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 698758002738 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 698758002739 HIGH motif; other site 698758002740 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698758002741 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 698758002742 active site 698758002743 KMSKS motif; other site 698758002744 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 698758002745 tRNA binding surface [nucleotide binding]; other site 698758002746 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698758002747 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698758002748 Walker A/P-loop; other site 698758002749 ATP binding site [chemical binding]; other site 698758002750 Q-loop/lid; other site 698758002751 ABC transporter signature motif; other site 698758002752 Walker B; other site 698758002753 D-loop; other site 698758002754 H-loop/switch region; other site 698758002755 Predicted transcriptional regulators [Transcription]; Region: COG1725 698758002756 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698758002757 DNA-binding site [nucleotide binding]; DNA binding site 698758002758 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698758002759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698758002760 non-specific DNA binding site [nucleotide binding]; other site 698758002761 salt bridge; other site 698758002762 sequence-specific DNA binding site [nucleotide binding]; other site 698758002763 Transposase; Region: HTH_Tnp_1; cl17663 698758002764 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 698758002765 homopentamer interface [polypeptide binding]; other site 698758002766 active site 698758002767 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 698758002768 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 698758002769 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 698758002770 dimerization interface [polypeptide binding]; other site 698758002771 active site 698758002772 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 698758002773 Lumazine binding domain; Region: Lum_binding; pfam00677 698758002774 Lumazine binding domain; Region: Lum_binding; pfam00677 698758002775 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 698758002776 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 698758002777 catalytic motif [active] 698758002778 Zn binding site [ion binding]; other site 698758002779 RibD C-terminal domain; Region: RibD_C; cl17279 698758002780 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 698758002781 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698758002782 HD domain; Region: HD_4; pfam13328 698758002783 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698758002784 amino acid carrier protein; Region: agcS; TIGR00835 698758002785 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 698758002786 HI0933-like protein; Region: HI0933_like; pfam03486 698758002787 stage V sporulation protein B; Region: spore_V_B; TIGR02900 698758002788 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 698758002789 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698758002790 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698758002791 RNA binding surface [nucleotide binding]; other site 698758002792 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 698758002793 active site 698758002794 uracil binding [chemical binding]; other site 698758002795 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 698758002796 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 698758002797 Phosphotransferase enzyme family; Region: APH; pfam01636 698758002798 active site 698758002799 substrate binding site [chemical binding]; other site 698758002800 ATP binding site [chemical binding]; other site 698758002801 Predicted small secreted protein [Function unknown]; Region: COG5584 698758002802 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 698758002803 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 698758002804 oligomer interface [polypeptide binding]; other site 698758002805 active site 698758002806 metal binding site [ion binding]; metal-binding site 698758002807 NTPase; Reviewed; Region: PRK03114 698758002808 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 698758002809 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 698758002810 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698758002811 catalytic residues [active] 698758002812 hypothetical protein; Provisional; Region: PRK13668 698758002813 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698758002814 putative tRNA-binding site [nucleotide binding]; other site 698758002815 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698758002816 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698758002817 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 698758002818 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 698758002819 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 698758002820 active site 698758002821 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 698758002822 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698758002823 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698758002824 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698758002825 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 698758002826 YtxH-like protein; Region: YtxH; pfam12732 698758002827 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 698758002828 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698758002829 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 698758002830 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 698758002831 Cell division protein FtsA; Region: FtsA; smart00842 698758002832 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698758002833 nucleotide binding site [chemical binding]; other site 698758002834 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 698758002835 Chorismate mutase type II; Region: CM_2; cl00693 698758002836 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 698758002837 catabolite control protein A; Region: ccpA; TIGR01481 698758002838 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698758002839 DNA binding site [nucleotide binding] 698758002840 domain linker motif; other site 698758002841 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 698758002842 dimerization interface [polypeptide binding]; other site 698758002843 effector binding site; other site 698758002844 flagellar motor protein MotP; Reviewed; Region: PRK06926 698758002845 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 698758002846 flagellar motor protein MotS; Reviewed; Region: PRK06925 698758002847 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 698758002848 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 698758002849 ligand binding site [chemical binding]; other site 698758002850 Transglycosylase; Region: Transgly; pfam00912 698758002851 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 698758002852 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698758002853 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 698758002854 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 698758002855 active site 698758002856 HIGH motif; other site 698758002857 dimer interface [polypeptide binding]; other site 698758002858 KMSKS motif; other site 698758002859 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698758002860 RNA binding surface [nucleotide binding]; other site 698758002861 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 698758002862 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 698758002863 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698758002864 RNA binding surface [nucleotide binding]; other site 698758002865 GAF domain; Region: GAF_2; pfam13185 698758002866 GAF domain; Region: GAF_3; pfam13492 698758002867 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698758002868 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698758002869 metal binding site [ion binding]; metal-binding site 698758002870 active site 698758002871 I-site; other site 698758002872 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 698758002873 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 698758002874 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 698758002875 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698758002876 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 698758002877 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698758002878 catalytic residue [active] 698758002879 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 698758002880 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 698758002881 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 698758002882 Ligand Binding Site [chemical binding]; other site 698758002883 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 698758002884 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 698758002885 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 698758002886 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 698758002887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758002888 S-adenosylmethionine binding site [chemical binding]; other site 698758002889 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 698758002890 propionate/acetate kinase; Provisional; Region: PRK12379 698758002891 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698758002892 Ligand Binding Site [chemical binding]; other site 698758002893 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 698758002894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698758002895 DNA-binding site [nucleotide binding]; DNA binding site 698758002896 DRTGG domain; Region: DRTGG; pfam07085 698758002897 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 698758002898 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 698758002899 active site 2 [active] 698758002900 active site 1 [active] 698758002901 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 698758002902 DHH family; Region: DHH; pfam01368 698758002903 DHHA1 domain; Region: DHHA1; pfam02272 698758002904 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 698758002905 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 698758002906 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 698758002907 active site 698758002908 PHP Thumb interface [polypeptide binding]; other site 698758002909 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698758002910 generic binding surface II; other site 698758002911 generic binding surface I; other site 698758002912 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 698758002913 Malic enzyme, N-terminal domain; Region: malic; pfam00390 698758002914 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 698758002915 putative NAD(P) binding site [chemical binding]; other site 698758002916 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 698758002917 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698758002918 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 698758002919 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 698758002920 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 698758002921 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 698758002922 active site 698758002923 ADP/pyrophosphate binding site [chemical binding]; other site 698758002924 dimerization interface [polypeptide binding]; other site 698758002925 allosteric effector site; other site 698758002926 fructose-1,6-bisphosphate binding site; other site 698758002927 pyruvate kinase; Provisional; Region: PRK06354 698758002928 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 698758002929 domain interfaces; other site 698758002930 active site 698758002931 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 698758002932 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 698758002933 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 698758002934 Protein of unknown function (DUF441); Region: DUF441; pfam04284 698758002935 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 698758002936 Citrate synthase; Region: Citrate_synt; pfam00285 698758002937 oxalacetate binding site [chemical binding]; other site 698758002938 citrylCoA binding site [chemical binding]; other site 698758002939 coenzyme A binding site [chemical binding]; other site 698758002940 catalytic triad [active] 698758002941 isocitrate dehydrogenase; Reviewed; Region: PRK07006 698758002942 isocitrate dehydrogenase; Validated; Region: PRK07362 698758002943 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698758002944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758002945 active site 698758002946 phosphorylation site [posttranslational modification] 698758002947 intermolecular recognition site; other site 698758002948 dimerization interface [polypeptide binding]; other site 698758002949 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698758002950 DNA binding site [nucleotide binding] 698758002951 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698758002952 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698758002953 putative active site [active] 698758002954 heme pocket [chemical binding]; other site 698758002955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698758002956 dimer interface [polypeptide binding]; other site 698758002957 phosphorylation site [posttranslational modification] 698758002958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758002959 ATP binding site [chemical binding]; other site 698758002960 Mg2+ binding site [ion binding]; other site 698758002961 G-X-G motif; other site 698758002962 DNA polymerase I; Provisional; Region: PRK05755 698758002963 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698758002964 active site 698758002965 metal binding site 1 [ion binding]; metal-binding site 698758002966 putative 5' ssDNA interaction site; other site 698758002967 metal binding site 3; metal-binding site 698758002968 metal binding site 2 [ion binding]; metal-binding site 698758002969 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698758002970 putative DNA binding site [nucleotide binding]; other site 698758002971 putative metal binding site [ion binding]; other site 698758002972 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 698758002973 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 698758002974 active site 698758002975 DNA binding site [nucleotide binding] 698758002976 catalytic site [active] 698758002977 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 698758002978 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 698758002979 DNA binding site [nucleotide binding] 698758002980 catalytic residue [active] 698758002981 H2TH interface [polypeptide binding]; other site 698758002982 putative catalytic residues [active] 698758002983 turnover-facilitating residue; other site 698758002984 intercalation triad [nucleotide binding]; other site 698758002985 8OG recognition residue [nucleotide binding]; other site 698758002986 putative reading head residues; other site 698758002987 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698758002988 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698758002989 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 698758002990 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 698758002991 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 698758002992 CoA-binding site [chemical binding]; other site 698758002993 ATP-binding [chemical binding]; other site 698758002994 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 698758002995 ATP cone domain; Region: ATP-cone; pfam03477 698758002996 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 698758002997 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 698758002998 primosomal protein DnaI; Reviewed; Region: PRK08939 698758002999 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 698758003000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758003001 Walker A motif; other site 698758003002 ATP binding site [chemical binding]; other site 698758003003 Walker B motif; other site 698758003004 YtxC-like family; Region: YtxC; cl08500 698758003005 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 698758003006 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 698758003007 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698758003008 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698758003009 active site 698758003010 dimer interface [polypeptide binding]; other site 698758003011 motif 1; other site 698758003012 motif 2; other site 698758003013 motif 3; other site 698758003014 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698758003015 anticodon binding site; other site 698758003016 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 698758003017 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 698758003018 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 698758003019 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 698758003020 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 698758003021 23S rRNA binding site [nucleotide binding]; other site 698758003022 L21 binding site [polypeptide binding]; other site 698758003023 L13 binding site [polypeptide binding]; other site 698758003024 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 698758003025 Uncharacterized conserved protein [Function unknown]; Region: COG0398 698758003026 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698758003027 trimer interface [polypeptide binding]; other site 698758003028 active site 698758003029 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 698758003030 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 698758003031 oligomer interface [polypeptide binding]; other site 698758003032 active site 698758003033 metal binding site [ion binding]; metal-binding site 698758003034 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698758003035 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698758003036 Walker A/P-loop; other site 698758003037 ATP binding site [chemical binding]; other site 698758003038 Q-loop/lid; other site 698758003039 ABC transporter signature motif; other site 698758003040 Walker B; other site 698758003041 D-loop; other site 698758003042 H-loop/switch region; other site 698758003043 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 698758003044 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698758003045 FtsX-like permease family; Region: FtsX; pfam02687 698758003046 B12 binding domain; Region: B12-binding; pfam02310 698758003047 B12 binding site [chemical binding]; other site 698758003048 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 698758003049 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698758003050 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698758003051 catalytic residue [active] 698758003052 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 698758003053 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698758003054 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 698758003055 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698758003056 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698758003057 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698758003058 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698758003059 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698758003060 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 698758003061 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698758003062 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 698758003063 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 698758003064 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 698758003065 dimer interface [polypeptide binding]; other site 698758003066 motif 1; other site 698758003067 active site 698758003068 motif 2; other site 698758003069 motif 3; other site 698758003070 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 698758003071 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698758003072 putative tRNA-binding site [nucleotide binding]; other site 698758003073 B3/4 domain; Region: B3_4; pfam03483 698758003074 tRNA synthetase B5 domain; Region: B5; smart00874 698758003075 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 698758003076 dimer interface [polypeptide binding]; other site 698758003077 motif 1; other site 698758003078 motif 3; other site 698758003079 motif 2; other site 698758003080 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 698758003081 ribonuclease HIII; Provisional; Region: PRK00996 698758003082 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 698758003083 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 698758003084 RNA/DNA hybrid binding site [nucleotide binding]; other site 698758003085 active site 698758003086 Cell division protein ZapA; Region: ZapA; cl01146 698758003087 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 698758003088 Colicin V production protein; Region: Colicin_V; pfam02674 698758003089 hypothetical protein; Provisional; Region: PRK08609 698758003090 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 698758003091 active site 698758003092 primer binding site [nucleotide binding]; other site 698758003093 NTP binding site [chemical binding]; other site 698758003094 metal binding triad [ion binding]; metal-binding site 698758003095 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 698758003096 active site 698758003097 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 698758003098 MutS domain III; Region: MutS_III; pfam05192 698758003099 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 698758003100 Walker A/P-loop; other site 698758003101 ATP binding site [chemical binding]; other site 698758003102 Q-loop/lid; other site 698758003103 ABC transporter signature motif; other site 698758003104 Walker B; other site 698758003105 D-loop; other site 698758003106 H-loop/switch region; other site 698758003107 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 698758003108 Smr domain; Region: Smr; pfam01713 698758003109 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698758003110 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698758003111 catalytic residues [active] 698758003112 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 698758003113 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 698758003114 GIY-YIG motif/motif A; other site 698758003115 active site 698758003116 catalytic site [active] 698758003117 putative DNA binding site [nucleotide binding]; other site 698758003118 metal binding site [ion binding]; metal-binding site 698758003119 UvrB/uvrC motif; Region: UVR; pfam02151 698758003120 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 698758003121 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 698758003122 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698758003123 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698758003124 DNA binding residues [nucleotide binding] 698758003125 dimerization interface [polypeptide binding]; other site 698758003126 HTH-like domain; Region: HTH_21; pfam13276 698758003127 Integrase core domain; Region: rve; pfam00665 698758003128 Transposase; Region: HTH_Tnp_1; pfam01527 698758003129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698758003130 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698758003131 MarR family; Region: MarR_2; cl17246 698758003132 glutamate racemase; Provisional; Region: PRK00865 698758003133 Spore germination protein [General function prediction only]; Region: COG5401 698758003134 Sporulation and spore germination; Region: Germane; pfam10646 698758003135 Sporulation and spore germination; Region: Germane; pfam10646 698758003136 ribonuclease PH; Reviewed; Region: rph; PRK00173 698758003137 Ribonuclease PH; Region: RNase_PH_bact; cd11362 698758003138 hexamer interface [polypeptide binding]; other site 698758003139 active site 698758003140 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 698758003141 active site 698758003142 dimerization interface [polypeptide binding]; other site 698758003143 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 698758003144 active site 698758003145 metal binding site [ion binding]; metal-binding site 698758003146 homotetramer interface [polypeptide binding]; other site 698758003147 Nuclease-related domain; Region: NERD; pfam08378 698758003148 Small acid-soluble spore protein H family; Region: SspH; pfam08141 698758003149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698758003150 binding surface 698758003151 TPR motif; other site 698758003152 Protein of unknown function (DUF3196); Region: DUF3196; pfam11428 698758003153 trigger factor; Provisional; Region: tig; PRK01490 698758003154 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698758003155 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698758003156 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 698758003157 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 698758003158 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 698758003159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758003160 Walker A motif; other site 698758003161 ATP binding site [chemical binding]; other site 698758003162 Walker B motif; other site 698758003163 arginine finger; other site 698758003164 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698758003165 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 698758003166 Found in ATP-dependent protease La (LON); Region: LON; smart00464 698758003167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758003168 Walker A motif; other site 698758003169 ATP binding site [chemical binding]; other site 698758003170 Walker B motif; other site 698758003171 arginine finger; other site 698758003172 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 698758003173 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 698758003174 G1 box; other site 698758003175 GTP/Mg2+ binding site [chemical binding]; other site 698758003176 Switch I region; other site 698758003177 G2 box; other site 698758003178 G3 box; other site 698758003179 Switch II region; other site 698758003180 G4 box; other site 698758003181 G5 box; other site 698758003182 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698758003183 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 698758003184 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698758003185 active site 698758003186 HIGH motif; other site 698758003187 nucleotide binding site [chemical binding]; other site 698758003188 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698758003189 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698758003190 active site 698758003191 KMSKS motif; other site 698758003192 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 698758003193 tRNA binding surface [nucleotide binding]; other site 698758003194 anticodon binding site; other site 698758003195 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 698758003196 GAF domain; Region: GAF; cl17456 698758003197 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698758003198 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698758003199 metal binding site [ion binding]; metal-binding site 698758003200 active site 698758003201 I-site; other site 698758003202 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698758003203 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698758003204 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698758003205 PilX N-terminal; Region: PilX_N; pfam14341 698758003206 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 698758003207 type II secretion system protein E; Region: type_II_gspE; TIGR02533 698758003208 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 698758003209 Walker A motif; other site 698758003210 ATP binding site [chemical binding]; other site 698758003211 Walker B motif; other site 698758003212 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 698758003213 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698758003214 Walker A motif; other site 698758003215 ATP binding site [chemical binding]; other site 698758003216 Walker B motif; other site 698758003217 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 698758003218 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 698758003219 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 698758003220 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 698758003221 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 698758003222 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 698758003223 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 698758003224 Sporulation related domain; Region: SPOR; pfam05036 698758003225 hypothetical protein; Reviewed; Region: PRK00024 698758003226 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 698758003227 MPN+ (JAMM) motif; other site 698758003228 Zinc-binding site [ion binding]; other site 698758003229 Type II intron maturase; Region: Intron_maturas2; pfam01348 698758003230 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 698758003231 rod shape-determining protein MreB; Provisional; Region: PRK13927 698758003232 MreB and similar proteins; Region: MreB_like; cd10225 698758003233 nucleotide binding site [chemical binding]; other site 698758003234 Mg binding site [ion binding]; other site 698758003235 putative protofilament interaction site [polypeptide binding]; other site 698758003236 RodZ interaction site [polypeptide binding]; other site 698758003237 rod shape-determining protein MreC; Provisional; Region: PRK13922 698758003238 rod shape-determining protein MreC; Region: MreC; pfam04085 698758003239 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 698758003240 septum formation inhibitor; Reviewed; Region: minC; PRK00513 698758003241 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 698758003242 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 698758003243 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 698758003244 Switch I; other site 698758003245 Switch II; other site 698758003246 Peptidase family M23; Region: Peptidase_M23; pfam01551 698758003247 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 698758003248 Peptidase family M50; Region: Peptidase_M50; pfam02163 698758003249 active site 698758003250 putative substrate binding region [chemical binding]; other site 698758003251 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 698758003252 homodimer interface [polypeptide binding]; other site 698758003253 oligonucleotide binding site [chemical binding]; other site 698758003254 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 698758003255 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 698758003256 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 698758003257 Protein of unknown function (DUF464); Region: DUF464; pfam04327 698758003258 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 698758003259 GTPase CgtA; Reviewed; Region: obgE; PRK12297 698758003260 GTP1/OBG; Region: GTP1_OBG; pfam01018 698758003261 Obg GTPase; Region: Obg; cd01898 698758003262 G1 box; other site 698758003263 GTP/Mg2+ binding site [chemical binding]; other site 698758003264 Switch I region; other site 698758003265 G2 box; other site 698758003266 G3 box; other site 698758003267 Switch II region; other site 698758003268 G4 box; other site 698758003269 G5 box; other site 698758003270 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 698758003271 hypothetical protein; Provisional; Region: PRK04435 698758003272 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 698758003273 prephenate dehydratase; Provisional; Region: PRK11898 698758003274 Prephenate dehydratase; Region: PDT; pfam00800 698758003275 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698758003276 putative L-Phe binding site [chemical binding]; other site 698758003277 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 698758003278 HTH domain; Region: HTH_11; pfam08279 698758003279 3H domain; Region: 3H; pfam02829 698758003280 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698758003281 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698758003282 NAD synthase; Region: NAD_synthase; pfam02540 698758003283 homodimer interface [polypeptide binding]; other site 698758003284 NAD binding pocket [chemical binding]; other site 698758003285 ATP binding pocket [chemical binding]; other site 698758003286 Mg binding site [ion binding]; other site 698758003287 active-site loop [active] 698758003288 hypothetical protein; Validated; Region: PRK00110 698758003289 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 698758003290 BofC C-terminal domain; Region: BofC_C; pfam08955 698758003291 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 698758003292 RuvA N terminal domain; Region: RuvA_N; pfam01330 698758003293 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 698758003294 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 698758003295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758003296 Walker A motif; other site 698758003297 ATP binding site [chemical binding]; other site 698758003298 Walker B motif; other site 698758003299 arginine finger; other site 698758003300 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 698758003301 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 698758003302 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 698758003303 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 698758003304 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 698758003305 Preprotein translocase subunit; Region: YajC; pfam02699 698758003306 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 698758003307 Predicted membrane protein [Function unknown]; Region: COG2323 698758003308 stage V sporulation protein B; Region: spore_V_B; TIGR02900 698758003309 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 698758003310 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 698758003311 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 698758003312 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 698758003313 Protein export membrane protein; Region: SecD_SecF; cl14618 698758003314 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 698758003315 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 698758003316 DHH family; Region: DHH; pfam01368 698758003317 DHHA1 domain; Region: DHHA1; pfam02272 698758003318 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 698758003319 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698758003320 active site 698758003321 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698758003322 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698758003323 Zn2+ binding site [ion binding]; other site 698758003324 Mg2+ binding site [ion binding]; other site 698758003325 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698758003326 synthetase active site [active] 698758003327 NTP binding site [chemical binding]; other site 698758003328 metal binding site [ion binding]; metal-binding site 698758003329 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 698758003330 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 698758003331 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 698758003332 putative active site [active] 698758003333 dimerization interface [polypeptide binding]; other site 698758003334 putative tRNAtyr binding site [nucleotide binding]; other site 698758003335 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 698758003336 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 698758003337 Walker A/P-loop; other site 698758003338 ATP binding site [chemical binding]; other site 698758003339 Q-loop/lid; other site 698758003340 ABC transporter signature motif; other site 698758003341 Walker B; other site 698758003342 D-loop; other site 698758003343 H-loop/switch region; other site 698758003344 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 698758003345 PhoU domain; Region: PhoU; pfam01895 698758003346 PhoU domain; Region: PhoU; pfam01895 698758003347 Bacterial SH3 domain; Region: SH3_3; pfam08239 698758003348 Bacterial SH3 domain; Region: SH3_3; pfam08239 698758003349 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698758003350 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698758003351 active site 698758003352 metal binding site [ion binding]; metal-binding site 698758003353 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 698758003354 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 698758003355 dimer interface [polypeptide binding]; other site 698758003356 motif 1; other site 698758003357 active site 698758003358 motif 2; other site 698758003359 motif 3; other site 698758003360 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 698758003361 anticodon binding site; other site 698758003362 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 698758003363 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 698758003364 dimer interface [polypeptide binding]; other site 698758003365 anticodon binding site; other site 698758003366 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 698758003367 homodimer interface [polypeptide binding]; other site 698758003368 motif 1; other site 698758003369 active site 698758003370 motif 2; other site 698758003371 GAD domain; Region: GAD; pfam02938 698758003372 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698758003373 active site 698758003374 motif 3; other site 698758003375 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 698758003376 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 698758003377 recombination factor protein RarA; Reviewed; Region: PRK13342 698758003378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758003379 Walker A motif; other site 698758003380 ATP binding site [chemical binding]; other site 698758003381 Walker B motif; other site 698758003382 arginine finger; other site 698758003383 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 698758003384 Predicted transcriptional regulator [Transcription]; Region: COG1959 698758003385 Transcriptional regulator; Region: Rrf2; pfam02082 698758003386 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698758003387 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 698758003388 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698758003389 catalytic residue [active] 698758003390 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 698758003391 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 698758003392 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 698758003393 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 698758003394 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 698758003395 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 698758003396 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 698758003397 AAA domain; Region: AAA_30; pfam13604 698758003398 Family description; Region: UvrD_C_2; pfam13538 698758003399 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698758003400 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698758003401 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 698758003402 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 698758003403 motif 1; other site 698758003404 active site 698758003405 motif 2; other site 698758003406 motif 3; other site 698758003407 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698758003408 DHHA1 domain; Region: DHHA1; pfam02272 698758003409 hypothetical protein; Provisional; Region: PRK05473 698758003410 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 698758003411 hypothetical protein; Provisional; Region: PRK13678 698758003412 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 698758003413 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 698758003414 G1 box; other site 698758003415 putative GEF interaction site [polypeptide binding]; other site 698758003416 GTP/Mg2+ binding site [chemical binding]; other site 698758003417 Switch I region; other site 698758003418 G2 box; other site 698758003419 G3 box; other site 698758003420 Switch II region; other site 698758003421 G4 box; other site 698758003422 G5 box; other site 698758003423 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 698758003424 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 698758003425 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 698758003426 YceG-like family; Region: YceG; pfam02618 698758003427 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 698758003428 dimerization interface [polypeptide binding]; other site 698758003429 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 698758003430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758003431 S-adenosylmethionine binding site [chemical binding]; other site 698758003432 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 698758003433 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 698758003434 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698758003435 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 698758003436 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 698758003437 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 698758003438 sporulation sigma factor SigK; Reviewed; Region: PRK05803 698758003439 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698758003440 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698758003441 DNA binding residues [nucleotide binding] 698758003442 Sporulation inhibitor A; Region: Sda; pfam08970 698758003443 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 698758003444 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758003445 active site 698758003446 motif I; other site 698758003447 motif II; other site 698758003448 GTPase YqeH; Provisional; Region: PRK13796 698758003449 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 698758003450 GTP/Mg2+ binding site [chemical binding]; other site 698758003451 G4 box; other site 698758003452 G5 box; other site 698758003453 G1 box; other site 698758003454 Switch I region; other site 698758003455 G2 box; other site 698758003456 G3 box; other site 698758003457 Switch II region; other site 698758003458 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 698758003459 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698758003460 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698758003461 shikimate binding site; other site 698758003462 NAD(P) binding site [chemical binding]; other site 698758003463 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 698758003464 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 698758003465 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 698758003466 active site 698758003467 (T/H)XGH motif; other site 698758003468 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698758003469 Zn2+ binding site [ion binding]; other site 698758003470 Mg2+ binding site [ion binding]; other site 698758003471 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 698758003472 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698758003473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758003474 S-adenosylmethionine binding site [chemical binding]; other site 698758003475 SLBB domain; Region: SLBB; pfam10531 698758003476 comEA protein; Region: comE; TIGR01259 698758003477 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698758003478 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 698758003479 catalytic motif [active] 698758003480 Zn binding site [ion binding]; other site 698758003481 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 698758003482 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 698758003483 Competence protein; Region: Competence; pfam03772 698758003484 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698758003485 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 698758003486 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 698758003487 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 698758003488 germination protease; Provisional; Region: PRK02858 698758003489 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 698758003490 stage II sporulation protein P; Region: spore_II_P; TIGR02867 698758003491 GTP-binding protein LepA; Provisional; Region: PRK05433 698758003492 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 698758003493 G1 box; other site 698758003494 putative GEF interaction site [polypeptide binding]; other site 698758003495 GTP/Mg2+ binding site [chemical binding]; other site 698758003496 Switch I region; other site 698758003497 G2 box; other site 698758003498 G3 box; other site 698758003499 Switch II region; other site 698758003500 G4 box; other site 698758003501 G5 box; other site 698758003502 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 698758003503 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 698758003504 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 698758003505 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 698758003506 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698758003507 FeS/SAM binding site; other site 698758003508 HemN C-terminal domain; Region: HemN_C; pfam06969 698758003509 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 698758003510 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 698758003511 heat shock protein GrpE; Provisional; Region: PRK14140 698758003512 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 698758003513 dimer interface [polypeptide binding]; other site 698758003514 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 698758003515 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 698758003516 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 698758003517 nucleotide binding site [chemical binding]; other site 698758003518 NEF interaction site [polypeptide binding]; other site 698758003519 SBD interface [polypeptide binding]; other site 698758003520 chaperone protein DnaJ; Provisional; Region: PRK14280 698758003521 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698758003522 HSP70 interaction site [polypeptide binding]; other site 698758003523 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 698758003524 substrate binding site [polypeptide binding]; other site 698758003525 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698758003526 Zn binding sites [ion binding]; other site 698758003527 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698758003528 dimer interface [polypeptide binding]; other site 698758003529 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 698758003530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758003531 S-adenosylmethionine binding site [chemical binding]; other site 698758003532 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 698758003533 RNA methyltransferase, RsmE family; Region: TIGR00046 698758003534 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 698758003535 Yqey-like protein; Region: YqeY; pfam09424 698758003536 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 698758003537 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 698758003538 dimer interface [polypeptide binding]; other site 698758003539 active site residues [active] 698758003540 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 698758003541 hypothetical protein; Provisional; Region: PRK13665 698758003542 YabP family; Region: YabP; cl06766 698758003543 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 698758003544 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 698758003545 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 698758003546 PhoH-like protein; Region: PhoH; pfam02562 698758003547 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 698758003548 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 698758003549 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698758003550 Zn2+ binding site [ion binding]; other site 698758003551 Mg2+ binding site [ion binding]; other site 698758003552 metal-binding heat shock protein; Provisional; Region: PRK00016 698758003553 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 698758003554 GTPase Era; Reviewed; Region: era; PRK00089 698758003555 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 698758003556 G1 box; other site 698758003557 GTP/Mg2+ binding site [chemical binding]; other site 698758003558 Switch I region; other site 698758003559 G2 box; other site 698758003560 Switch II region; other site 698758003561 G3 box; other site 698758003562 G4 box; other site 698758003563 G5 box; other site 698758003564 KH domain; Region: KH_2; pfam07650 698758003565 G-X-X-G motif; other site 698758003566 Recombination protein O N terminal; Region: RecO_N; pfam11967 698758003567 DNA repair protein RecO; Region: reco; TIGR00613 698758003568 Recombination protein O C terminal; Region: RecO_C; pfam02565 698758003569 D-glutamate deacylase; Validated; Region: PRK09061 698758003570 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698758003571 active site 698758003572 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 698758003573 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 698758003574 dimer interface [polypeptide binding]; other site 698758003575 motif 1; other site 698758003576 active site 698758003577 motif 2; other site 698758003578 motif 3; other site 698758003579 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 698758003580 DALR anticodon binding domain; Region: DALR_1; pfam05746 698758003581 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 698758003582 DNA primase; Validated; Region: dnaG; PRK05667 698758003583 CHC2 zinc finger; Region: zf-CHC2; pfam01807 698758003584 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 698758003585 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 698758003586 active site 698758003587 metal binding site [ion binding]; metal-binding site 698758003588 interdomain interaction site; other site 698758003589 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 698758003590 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 698758003591 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 698758003592 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698758003593 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698758003594 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698758003595 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698758003596 DNA binding residues [nucleotide binding] 698758003597 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 698758003598 Family of unknown function (DUF633); Region: DUF633; pfam04816 698758003599 Uncharacterized conserved protein [Function unknown]; Region: COG0327 698758003600 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698758003601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 698758003602 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698758003603 Uncharacterized conserved protein [Function unknown]; Region: COG0327 698758003604 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698758003605 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 698758003606 ATP binding site [chemical binding]; other site 698758003607 putative Mg++ binding site [ion binding]; other site 698758003608 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698758003609 nucleotide binding region [chemical binding]; other site 698758003610 ATP-binding site [chemical binding]; other site 698758003611 endonuclease IV; Provisional; Region: PRK01060 698758003612 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 698758003613 AP (apurinic/apyrimidinic) site pocket; other site 698758003614 DNA interaction; other site 698758003615 Metal-binding active site; metal-binding site 698758003616 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 698758003617 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 698758003618 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698758003619 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698758003620 catalytic residue [active] 698758003621 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 698758003622 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 698758003623 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 698758003624 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 698758003625 PhoU domain; Region: PhoU; pfam01895 698758003626 PhoU domain; Region: PhoU; pfam01895 698758003627 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 698758003628 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 698758003629 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 698758003630 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 698758003631 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698758003632 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698758003633 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698758003634 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698758003635 YceG-like family; Region: YceG; pfam02618 698758003636 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 698758003637 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 698758003638 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 698758003639 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 698758003640 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 698758003641 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698758003642 nucleotide binding site [chemical binding]; other site 698758003643 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 698758003644 Sulfatase; Region: Sulfatase; pfam00884 698758003645 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698758003646 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 698758003647 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 698758003648 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 698758003649 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 698758003650 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 698758003651 Type II/IV secretion system protein; Region: T2SE; pfam00437 698758003652 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698758003653 Walker A motif; other site 698758003654 ATP binding site [chemical binding]; other site 698758003655 Walker B motif; other site 698758003656 shikimate kinase; Reviewed; Region: aroK; PRK00131 698758003657 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 698758003658 ADP binding site [chemical binding]; other site 698758003659 magnesium binding site [ion binding]; other site 698758003660 putative shikimate binding site; other site 698758003661 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 698758003662 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698758003663 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698758003664 ATP binding site [chemical binding]; other site 698758003665 putative Mg++ binding site [ion binding]; other site 698758003666 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698758003667 nucleotide binding region [chemical binding]; other site 698758003668 ATP-binding site [chemical binding]; other site 698758003669 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698758003670 active site residue [active] 698758003671 manganese transport transcriptional regulator; Provisional; Region: PRK03902 698758003672 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698758003673 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698758003674 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 698758003675 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 698758003676 active site 698758003677 nucleophile elbow; other site 698758003678 Conserved membrane protein YqhR; Region: YqhR; pfam11085 698758003679 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698758003680 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698758003681 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698758003682 active site 698758003683 elongation factor P; Validated; Region: PRK00529 698758003684 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 698758003685 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 698758003686 RNA binding site [nucleotide binding]; other site 698758003687 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 698758003688 RNA binding site [nucleotide binding]; other site 698758003689 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 698758003690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758003691 Walker A motif; other site 698758003692 ATP binding site [chemical binding]; other site 698758003693 Walker B motif; other site 698758003694 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 698758003695 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 698758003696 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 698758003697 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 698758003698 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 698758003699 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 698758003700 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 698758003701 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 698758003702 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698758003703 carboxyltransferase (CT) interaction site; other site 698758003704 biotinylation site [posttranslational modification]; other site 698758003705 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 698758003706 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698758003707 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698758003708 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698758003709 Asp23 family; Region: Asp23; pfam03780 698758003710 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 698758003711 putative RNA binding site [nucleotide binding]; other site 698758003712 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 698758003713 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698758003714 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698758003715 homodimer interface [polypeptide binding]; other site 698758003716 NADP binding site [chemical binding]; other site 698758003717 substrate binding site [chemical binding]; other site 698758003718 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 698758003719 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 698758003720 generic binding surface II; other site 698758003721 generic binding surface I; other site 698758003722 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 698758003723 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698758003724 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698758003725 substrate binding pocket [chemical binding]; other site 698758003726 chain length determination region; other site 698758003727 substrate-Mg2+ binding site; other site 698758003728 catalytic residues [active] 698758003729 aspartate-rich region 1; other site 698758003730 active site lid residues [active] 698758003731 aspartate-rich region 2; other site 698758003732 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 698758003733 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698758003734 RNA binding surface [nucleotide binding]; other site 698758003735 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 698758003736 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 698758003737 arginine repressor; Provisional; Region: PRK04280 698758003738 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 698758003739 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 698758003740 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698758003741 Walker A/P-loop; other site 698758003742 ATP binding site [chemical binding]; other site 698758003743 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698758003744 ABC transporter signature motif; other site 698758003745 Walker B; other site 698758003746 D-loop; other site 698758003747 H-loop/switch region; other site 698758003748 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 698758003749 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698758003750 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 698758003751 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 698758003752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758003753 active site 698758003754 phosphorylation site [posttranslational modification] 698758003755 intermolecular recognition site; other site 698758003756 dimerization interface [polypeptide binding]; other site 698758003757 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 698758003758 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698758003759 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 698758003760 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 698758003761 aspartate kinase; Reviewed; Region: PRK09034 698758003762 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 698758003763 nucleotide binding site [chemical binding]; other site 698758003764 substrate binding site [chemical binding]; other site 698758003765 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 698758003766 allosteric regulatory residue; other site 698758003767 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 698758003768 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 698758003769 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698758003770 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698758003771 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698758003772 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 698758003773 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 698758003774 tetramer interface [polypeptide binding]; other site 698758003775 TPP-binding site [chemical binding]; other site 698758003776 heterodimer interface [polypeptide binding]; other site 698758003777 phosphorylation loop region [posttranslational modification] 698758003778 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 698758003779 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 698758003780 alpha subunit interface [polypeptide binding]; other site 698758003781 TPP binding site [chemical binding]; other site 698758003782 heterodimer interface [polypeptide binding]; other site 698758003783 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698758003784 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 698758003785 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698758003786 E3 interaction surface; other site 698758003787 lipoyl attachment site [posttranslational modification]; other site 698758003788 e3 binding domain; Region: E3_binding; pfam02817 698758003789 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698758003790 Predicted membrane protein [Function unknown]; Region: COG4129 698758003791 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 698758003792 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 698758003793 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 698758003794 peptidase T-like protein; Region: PepT-like; TIGR01883 698758003795 metal binding site [ion binding]; metal-binding site 698758003796 putative dimer interface [polypeptide binding]; other site 698758003797 DNA polymerase IV; Validated; Region: PRK01810 698758003798 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698758003799 active site 698758003800 DNA binding site [nucleotide binding] 698758003801 ribonuclease Z; Region: RNase_Z; TIGR02651 698758003802 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698758003803 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 698758003804 active site 698758003805 catalytic site [active] 698758003806 metal binding site [ion binding]; metal-binding site 698758003807 dimer interface [polypeptide binding]; other site 698758003808 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698758003809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698758003810 NAD(P) binding site [chemical binding]; other site 698758003811 active site 698758003812 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 698758003813 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698758003814 dimer interface [polypeptide binding]; other site 698758003815 ADP-ribose binding site [chemical binding]; other site 698758003816 active site 698758003817 nudix motif; other site 698758003818 metal binding site [ion binding]; metal-binding site 698758003819 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 698758003820 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 698758003821 PHP-associated; Region: PHP_C; pfam13263 698758003822 Integral membrane protein DUF95; Region: DUF95; cl00572 698758003823 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698758003824 metal binding site 2 [ion binding]; metal-binding site 698758003825 putative DNA binding helix; other site 698758003826 metal binding site 1 [ion binding]; metal-binding site 698758003827 dimer interface [polypeptide binding]; other site 698758003828 structural Zn2+ binding site [ion binding]; other site 698758003829 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 698758003830 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 698758003831 active site 698758003832 Int/Topo IB signature motif; other site 698758003833 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698758003834 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 698758003835 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 698758003836 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 698758003837 anti sigma factor interaction site; other site 698758003838 regulatory phosphorylation site [posttranslational modification]; other site 698758003839 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 698758003840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758003841 ATP binding site [chemical binding]; other site 698758003842 Mg2+ binding site [ion binding]; other site 698758003843 G-X-G motif; other site 698758003844 sporulation sigma factor SigF; Validated; Region: PRK05572 698758003845 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698758003846 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698758003847 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698758003848 DNA binding residues [nucleotide binding] 698758003849 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 698758003850 diaminopimelate decarboxylase; Region: lysA; TIGR01048 698758003851 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698758003852 active site 698758003853 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698758003854 substrate binding site [chemical binding]; other site 698758003855 catalytic residues [active] 698758003856 dimer interface [polypeptide binding]; other site 698758003857 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698758003858 active site 698758003859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698758003860 Coenzyme A binding pocket [chemical binding]; other site 698758003861 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 698758003862 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 698758003863 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698758003864 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698758003865 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 698758003866 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 698758003867 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698758003868 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698758003869 RNA binding surface [nucleotide binding]; other site 698758003870 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 698758003871 active site 698758003872 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698758003873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758003874 active site 698758003875 phosphorylation site [posttranslational modification] 698758003876 intermolecular recognition site; other site 698758003877 dimerization interface [polypeptide binding]; other site 698758003878 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698758003879 DNA binding site [nucleotide binding] 698758003880 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698758003881 dimerization interface [polypeptide binding]; other site 698758003882 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698758003883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698758003884 dimer interface [polypeptide binding]; other site 698758003885 phosphorylation site [posttranslational modification] 698758003886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758003887 ATP binding site [chemical binding]; other site 698758003888 Mg2+ binding site [ion binding]; other site 698758003889 G-X-G motif; other site 698758003890 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 698758003891 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698758003892 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698758003893 DNA binding residues [nucleotide binding] 698758003894 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 698758003895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 698758003896 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 698758003897 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698758003898 ATP binding site [chemical binding]; other site 698758003899 putative Mg++ binding site [ion binding]; other site 698758003900 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698758003901 nucleotide binding region [chemical binding]; other site 698758003902 ATP-binding site [chemical binding]; other site 698758003903 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 698758003904 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698758003905 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 698758003906 germination protein YpeB; Region: spore_YpeB; TIGR02889 698758003907 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 698758003908 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 698758003909 putative active site [active] 698758003910 putative NTP binding site [chemical binding]; other site 698758003911 putative nucleic acid binding site [nucleotide binding]; other site 698758003912 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 698758003913 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 698758003914 Flagellar protein YcgR; Region: YcgR_2; pfam12945 698758003915 PilZ domain; Region: PilZ; pfam07238 698758003916 cytidylate kinase; Provisional; Region: cmk; PRK00023 698758003917 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 698758003918 CMP-binding site; other site 698758003919 The sites determining sugar specificity; other site 698758003920 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698758003921 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698758003922 putative acyl-acceptor binding pocket; other site 698758003923 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 698758003924 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 698758003925 RNA binding site [nucleotide binding]; other site 698758003926 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 698758003927 RNA binding site [nucleotide binding]; other site 698758003928 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 698758003929 RNA binding site [nucleotide binding]; other site 698758003930 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 698758003931 RNA binding site [nucleotide binding]; other site 698758003932 GTP-binding protein Der; Reviewed; Region: PRK00093 698758003933 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 698758003934 G1 box; other site 698758003935 GTP/Mg2+ binding site [chemical binding]; other site 698758003936 Switch I region; other site 698758003937 G2 box; other site 698758003938 Switch II region; other site 698758003939 G3 box; other site 698758003940 G4 box; other site 698758003941 G5 box; other site 698758003942 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 698758003943 G1 box; other site 698758003944 GTP/Mg2+ binding site [chemical binding]; other site 698758003945 Switch I region; other site 698758003946 G2 box; other site 698758003947 G3 box; other site 698758003948 Switch II region; other site 698758003949 G4 box; other site 698758003950 G5 box; other site 698758003951 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 698758003952 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698758003953 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 698758003954 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 698758003955 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 698758003956 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 698758003957 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 698758003958 IHF - DNA interface [nucleotide binding]; other site 698758003959 IHF dimer interface [polypeptide binding]; other site 698758003960 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 698758003961 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 698758003962 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698758003963 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698758003964 substrate binding pocket [chemical binding]; other site 698758003965 chain length determination region; other site 698758003966 substrate-Mg2+ binding site; other site 698758003967 catalytic residues [active] 698758003968 aspartate-rich region 1; other site 698758003969 active site lid residues [active] 698758003970 aspartate-rich region 2; other site 698758003971 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 698758003972 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 698758003973 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 698758003974 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698758003975 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698758003976 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698758003977 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 698758003978 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 698758003979 Tetramer interface [polypeptide binding]; other site 698758003980 active site 698758003981 FMN-binding site [chemical binding]; other site 698758003982 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 698758003983 active site 698758003984 dimer interface [polypeptide binding]; other site 698758003985 metal binding site [ion binding]; metal-binding site 698758003986 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 698758003987 homotrimer interaction site [polypeptide binding]; other site 698758003988 active site 698758003989 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 698758003990 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698758003991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698758003992 homodimer interface [polypeptide binding]; other site 698758003993 catalytic residue [active] 698758003994 prephenate dehydrogenase; Validated; Region: PRK08507 698758003995 Prephenate dehydrogenase; Region: PDH; pfam02153 698758003996 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 698758003997 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 698758003998 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 698758003999 hinge; other site 698758004000 active site 698758004001 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 698758004002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698758004003 binding surface 698758004004 TPR motif; other site 698758004005 TPR repeat; Region: TPR_11; pfam13414 698758004006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698758004007 binding surface 698758004008 TPR motif; other site 698758004009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698758004010 TPR motif; other site 698758004011 binding surface 698758004012 hypothetical protein; Provisional; Region: PRK03636 698758004013 UPF0302 domain; Region: UPF0302; pfam08864 698758004014 IDEAL domain; Region: IDEAL; pfam08858 698758004015 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 698758004016 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 698758004017 homodimer interface [polypeptide binding]; other site 698758004018 metal binding site [ion binding]; metal-binding site 698758004019 dihydrodipicolinate reductase; Provisional; Region: PRK00048 698758004020 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 698758004021 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 698758004022 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 698758004023 active site 698758004024 dimer interfaces [polypeptide binding]; other site 698758004025 catalytic residues [active] 698758004026 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 698758004027 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 698758004028 active site 698758004029 NTP binding site [chemical binding]; other site 698758004030 metal binding triad [ion binding]; metal-binding site 698758004031 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 698758004032 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 698758004033 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698758004034 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698758004035 putative DNA binding site [nucleotide binding]; other site 698758004036 putative Zn2+ binding site [ion binding]; other site 698758004037 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 698758004038 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 698758004039 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 698758004040 active site 698758004041 oligomerization interface [polypeptide binding]; other site 698758004042 metal binding site [ion binding]; metal-binding site 698758004043 pantoate--beta-alanine ligase; Region: panC; TIGR00018 698758004044 Pantoate-beta-alanine ligase; Region: PanC; cd00560 698758004045 active site 698758004046 ATP-binding site [chemical binding]; other site 698758004047 pantoate-binding site; other site 698758004048 HXXH motif; other site 698758004049 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 698758004050 tetramerization interface [polypeptide binding]; other site 698758004051 active site 698758004052 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 698758004053 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698758004054 active site 698758004055 catalytic site [active] 698758004056 substrate binding site [chemical binding]; other site 698758004057 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698758004058 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698758004059 putative Mg++ binding site [ion binding]; other site 698758004060 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 698758004061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 698758004062 aspartate aminotransferase; Provisional; Region: PRK05764 698758004063 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698758004064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698758004065 homodimer interface [polypeptide binding]; other site 698758004066 catalytic residue [active] 698758004067 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 698758004068 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 698758004069 putative dimer interface [polypeptide binding]; other site 698758004070 putative anticodon binding site; other site 698758004071 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 698758004072 homodimer interface [polypeptide binding]; other site 698758004073 motif 1; other site 698758004074 motif 2; other site 698758004075 active site 698758004076 motif 3; other site 698758004077 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 698758004078 Helix-turn-helix domain; Region: HTH_36; pfam13730 698758004079 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 698758004080 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 698758004081 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698758004082 minor groove reading motif; other site 698758004083 helix-hairpin-helix signature motif; other site 698758004084 substrate binding pocket [chemical binding]; other site 698758004085 active site 698758004086 Transglycosylase; Region: Transgly; pfam00912 698758004087 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 698758004088 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698758004089 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 698758004090 Interdomain contacts; other site 698758004091 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 698758004092 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 698758004093 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 698758004094 hypothetical protein; Provisional; Region: PRK13660 698758004095 cell division protein GpsB; Provisional; Region: PRK14127 698758004096 DivIVA domain; Region: DivI1A_domain; TIGR03544 698758004097 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 698758004098 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 698758004099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758004100 S-adenosylmethionine binding site [chemical binding]; other site 698758004101 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 698758004102 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 698758004103 active site 698758004104 Zn binding site [ion binding]; other site 698758004105 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 698758004106 RNA/DNA hybrid binding site [nucleotide binding]; other site 698758004107 active site 698758004108 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698758004109 DNA-binding site [nucleotide binding]; DNA binding site 698758004110 RNA-binding motif; other site 698758004111 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 698758004112 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698758004113 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698758004114 NlpC/P60 family; Region: NLPC_P60; pfam00877 698758004115 thymidylate synthase; Region: thym_sym; TIGR03284 698758004116 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 698758004117 dimerization interface [polypeptide binding]; other site 698758004118 active site 698758004119 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698758004120 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 698758004121 folate binding site [chemical binding]; other site 698758004122 NADP+ binding site [chemical binding]; other site 698758004123 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 698758004124 exonuclease subunit SbcD; Provisional; Region: PRK10966 698758004125 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698758004126 active site 698758004127 metal binding site [ion binding]; metal-binding site 698758004128 DNA binding site [nucleotide binding] 698758004129 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 698758004130 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698758004131 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 698758004132 Walker A/P-loop; other site 698758004133 ATP binding site [chemical binding]; other site 698758004134 Q-loop/lid; other site 698758004135 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 698758004136 ABC transporter signature motif; other site 698758004137 Walker B; other site 698758004138 D-loop; other site 698758004139 H-loop/switch region; other site 698758004140 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 698758004141 YqfQ-like protein; Region: YqfQ; pfam14181 698758004142 methionine sulfoxide reductase A; Provisional; Region: PRK14054 698758004143 methionine sulfoxide reductase B; Provisional; Region: PRK00222 698758004144 SelR domain; Region: SelR; pfam01641 698758004145 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698758004146 catalytic core [active] 698758004147 Ferredoxin [Energy production and conversion]; Region: COG1146 698758004148 4Fe-4S binding domain; Region: Fer4; pfam00037 698758004149 Acylphosphatase; Region: Acylphosphatase; pfam00708 698758004150 Uncharacterized conserved protein [Function unknown]; Region: COG5646 698758004151 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 698758004152 Peptidase family U32; Region: Peptidase_U32; pfam01136 698758004153 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 698758004154 Peptidase family U32; Region: Peptidase_U32; pfam01136 698758004155 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698758004156 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 698758004157 dimer interface [polypeptide binding]; other site 698758004158 putative metal binding site [ion binding]; other site 698758004159 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 698758004160 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698758004161 Coenzyme A binding pocket [chemical binding]; other site 698758004162 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 698758004163 substrate binding site [chemical binding]; other site 698758004164 active site 698758004165 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 698758004166 ligand binding site [chemical binding]; other site 698758004167 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698758004168 EDD domain protein, DegV family; Region: DegV; TIGR00762 698758004169 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698758004170 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 698758004171 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 698758004172 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698758004173 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 698758004174 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 698758004175 [2Fe-2S] cluster binding site [ion binding]; other site 698758004176 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698758004177 catalytic residues [active] 698758004178 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; pfam07972 698758004179 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 698758004180 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 698758004181 Class I ribonucleotide reductase; Region: RNR_I; cd01679 698758004182 active site 698758004183 dimer interface [polypeptide binding]; other site 698758004184 catalytic residues [active] 698758004185 effector binding site; other site 698758004186 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698758004187 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698758004188 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698758004189 dimer interface [polypeptide binding]; other site 698758004190 putative radical transfer pathway; other site 698758004191 diiron center [ion binding]; other site 698758004192 tyrosyl radical; other site 698758004193 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 698758004194 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698758004195 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698758004196 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698758004197 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698758004198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698758004199 putative substrate translocation pore; other site 698758004200 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 698758004201 homodimer interface [polypeptide binding]; other site 698758004202 catalytic residues [active] 698758004203 NAD binding site [chemical binding]; other site 698758004204 substrate binding pocket [chemical binding]; other site 698758004205 flexible flap; other site 698758004206 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 698758004207 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 698758004208 dimer interface [polypeptide binding]; other site 698758004209 active site 698758004210 putative acyltransferase; Provisional; Region: PRK05790 698758004211 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 698758004212 dimer interface [polypeptide binding]; other site 698758004213 active site 698758004214 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 698758004215 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 698758004216 DNA binding site [nucleotide binding] 698758004217 active site 698758004218 Chromate transporter; Region: Chromate_transp; pfam02417 698758004219 Chromate transporter; Region: Chromate_transp; pfam02417 698758004220 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 698758004221 heat shock protein 90; Provisional; Region: PRK05218 698758004222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758004223 ATP binding site [chemical binding]; other site 698758004224 Mg2+ binding site [ion binding]; other site 698758004225 G-X-G motif; other site 698758004226 IDEAL domain; Region: IDEAL; cl07452 698758004227 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 698758004228 V-type ATP synthase subunit B; Provisional; Region: PRK04196 698758004229 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698758004230 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 698758004231 Walker A motif homologous position; other site 698758004232 Walker B motif; other site 698758004233 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698758004234 V-type ATP synthase subunit A; Provisional; Region: PRK04192 698758004235 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698758004236 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 698758004237 Walker A motif/ATP binding site; other site 698758004238 Walker B motif; other site 698758004239 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698758004240 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 698758004241 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 698758004242 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 698758004243 V-type ATP synthase subunit K; Validated; Region: PRK06558 698758004244 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 698758004245 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 698758004246 V-type ATP synthase subunit I; Validated; Region: PRK05771 698758004247 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 698758004248 S1 domain; Region: S1_2; pfam13509 698758004249 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 698758004250 hypothetical protein; Validated; Region: PRK00124 698758004251 threonine dehydratase; Validated; Region: PRK08639 698758004252 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698758004253 tetramer interface [polypeptide binding]; other site 698758004254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698758004255 catalytic residue [active] 698758004256 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 698758004257 putative Ile/Val binding site [chemical binding]; other site 698758004258 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 698758004259 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698758004260 DHHA2 domain; Region: DHHA2; pfam02833 698758004261 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 698758004262 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 698758004263 putative catalytic cysteine [active] 698758004264 gamma-glutamyl kinase; Provisional; Region: PRK05429 698758004265 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 698758004266 nucleotide binding site [chemical binding]; other site 698758004267 homotetrameric interface [polypeptide binding]; other site 698758004268 putative phosphate binding site [ion binding]; other site 698758004269 putative allosteric binding site; other site 698758004270 PUA domain; Region: PUA; pfam01472 698758004271 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 698758004272 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 698758004273 homodimer interface [polypeptide binding]; other site 698758004274 substrate-cofactor binding pocket; other site 698758004275 catalytic residue [active] 698758004276 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698758004277 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698758004278 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 698758004279 putative dimerization interface [polypeptide binding]; other site 698758004280 methionine sulfoxide reductase A; Provisional; Region: PRK14054 698758004281 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 698758004282 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 698758004283 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 698758004284 metal binding site [ion binding]; metal-binding site 698758004285 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 698758004286 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698758004287 substrate binding site [chemical binding]; other site 698758004288 glutamase interaction surface [polypeptide binding]; other site 698758004289 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 698758004290 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 698758004291 catalytic residues [active] 698758004292 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 698758004293 putative active site pocket [active] 698758004294 4-fold oligomerization interface [polypeptide binding]; other site 698758004295 metal binding residues [ion binding]; metal-binding site 698758004296 3-fold/trimer interface [polypeptide binding]; other site 698758004297 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 698758004298 histidinol dehydrogenase; Region: hisD; TIGR00069 698758004299 NAD binding site [chemical binding]; other site 698758004300 dimerization interface [polypeptide binding]; other site 698758004301 product binding site; other site 698758004302 substrate binding site [chemical binding]; other site 698758004303 zinc binding site [ion binding]; other site 698758004304 catalytic residues [active] 698758004305 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 698758004306 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 698758004307 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 698758004308 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 698758004309 dimer interface [polypeptide binding]; other site 698758004310 motif 1; other site 698758004311 active site 698758004312 motif 2; other site 698758004313 motif 3; other site 698758004314 histidinol-phosphatase; Reviewed; Region: PRK08123 698758004315 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 698758004316 active site 698758004317 dimer interface [polypeptide binding]; other site 698758004318 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 698758004319 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 698758004320 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698758004321 CAP-like domain; other site 698758004322 active site 698758004323 primary dimer interface [polypeptide binding]; other site 698758004324 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698758004325 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698758004326 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698758004327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758004328 ATP binding site [chemical binding]; other site 698758004329 Mg2+ binding site [ion binding]; other site 698758004330 G-X-G motif; other site 698758004331 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698758004332 anchoring element; other site 698758004333 dimer interface [polypeptide binding]; other site 698758004334 ATP binding site [chemical binding]; other site 698758004335 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698758004336 active site 698758004337 putative metal-binding site [ion binding]; other site 698758004338 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698758004339 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 698758004340 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 698758004341 putative GTP cyclohydrolase; Provisional; Region: PRK13674 698758004342 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698758004343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698758004344 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698758004345 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698758004346 active site 698758004347 stage V sporulation protein K; Region: spore_V_K; TIGR02881 698758004348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758004349 Walker A motif; other site 698758004350 ATP binding site [chemical binding]; other site 698758004351 Walker B motif; other site 698758004352 arginine finger; other site 698758004353 stage V sporulation protein K; Region: spore_V_K; TIGR02881 698758004354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758004355 Walker A motif; other site 698758004356 ATP binding site [chemical binding]; other site 698758004357 Walker B motif; other site 698758004358 arginine finger; other site 698758004359 aconitate hydratase; Validated; Region: PRK09277 698758004360 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 698758004361 substrate binding site [chemical binding]; other site 698758004362 ligand binding site [chemical binding]; other site 698758004363 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 698758004364 substrate binding site [chemical binding]; other site 698758004365 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 698758004366 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698758004367 putative active site [active] 698758004368 heme pocket [chemical binding]; other site 698758004369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698758004370 dimer interface [polypeptide binding]; other site 698758004371 phosphorylation site [posttranslational modification] 698758004372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758004373 ATP binding site [chemical binding]; other site 698758004374 Mg2+ binding site [ion binding]; other site 698758004375 G-X-G motif; other site 698758004376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 698758004377 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 698758004378 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698758004379 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698758004380 TPP-binding site [chemical binding]; other site 698758004381 dimer interface [polypeptide binding]; other site 698758004382 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698758004383 PYR/PP interface [polypeptide binding]; other site 698758004384 dimer interface [polypeptide binding]; other site 698758004385 TPP binding site [chemical binding]; other site 698758004386 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698758004387 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 698758004388 LexA repressor; Validated; Region: PRK00215 698758004389 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698758004390 putative DNA binding site [nucleotide binding]; other site 698758004391 putative Zn2+ binding site [ion binding]; other site 698758004392 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698758004393 Catalytic site [active] 698758004394 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698758004395 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698758004396 active site 698758004397 metal binding site [ion binding]; metal-binding site 698758004398 Sporulation related domain; Region: SPOR; pfam05036 698758004399 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698758004400 active site 698758004401 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698758004402 dimerization interface [polypeptide binding]; other site 698758004403 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698758004404 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698758004405 dimer interface [polypeptide binding]; other site 698758004406 putative CheW interface [polypeptide binding]; other site 698758004407 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 698758004408 substrate binding pocket [chemical binding]; other site 698758004409 substrate-Mg2+ binding site; other site 698758004410 aspartate-rich region 1; other site 698758004411 aspartate-rich region 2; other site 698758004412 Uncharacterized conserved protein [Function unknown]; Region: COG0397 698758004413 hypothetical protein; Validated; Region: PRK00029 698758004414 amino acid transporter; Region: 2A0306; TIGR00909 698758004415 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 698758004416 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 698758004417 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 698758004418 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 698758004419 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 698758004420 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 698758004421 NAD(P) binding site [chemical binding]; other site 698758004422 Nuclease-related domain; Region: NERD; pfam08378 698758004423 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698758004424 active site residue [active] 698758004425 alpha-galactosidase; Region: PLN02808; cl17638 698758004426 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 698758004427 alpha-galactosidase; Region: PLN02808; cl17638 698758004428 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 698758004429 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 698758004430 PhnA protein; Region: PhnA; pfam03831 698758004431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758004432 S-adenosylmethionine binding site [chemical binding]; other site 698758004433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698758004434 Coenzyme A binding pocket [chemical binding]; other site 698758004435 Predicted transcriptional regulators [Transcription]; Region: COG1695 698758004436 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 698758004437 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 698758004438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698758004439 Coenzyme A binding pocket [chemical binding]; other site 698758004440 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 698758004441 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698758004442 Phosphotransferase enzyme family; Region: APH; pfam01636 698758004443 active site 698758004444 ATP binding site [chemical binding]; other site 698758004445 Virulence-associated protein E; Region: VirE; pfam05272 698758004446 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 698758004447 Low molecular weight phosphatase family; Region: LMWPc; cl00105 698758004448 active site 698758004449 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 698758004450 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 698758004451 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 698758004452 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698758004453 Integrase core domain; Region: rve; pfam00665 698758004454 DDE domain; Region: DDE_Tnp_IS240; pfam13610 698758004455 Integrase core domain; Region: rve_3; cl15866 698758004456 potential frameshift: common BLAST hit: gi|220930221|ref|YP_002507130.1| DNA-directed DNA polymerase 698758004457 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 698758004458 potential frameshift: common BLAST hit: gi|42779458|ref|NP_976705.1| DNA polymerase I 698758004459 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 698758004460 DNA binding site [nucleotide binding] 698758004461 active site 698758004462 catalytic site [active] 698758004463 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 698758004464 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 698758004465 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698758004466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698758004467 non-specific DNA binding site [nucleotide binding]; other site 698758004468 salt bridge; other site 698758004469 sequence-specific DNA binding site [nucleotide binding]; other site 698758004470 hypothetical protein; Provisional; Region: PHA02694 698758004471 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698758004472 non-specific DNA binding site [nucleotide binding]; other site 698758004473 salt bridge; other site 698758004474 sequence-specific DNA binding site [nucleotide binding]; other site 698758004475 Restriction endonuclease MspI; Region: Endonuc-MspI; pfam09208 698758004476 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 698758004477 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 698758004478 cofactor binding site; other site 698758004479 DNA binding site [nucleotide binding] 698758004480 substrate interaction site [chemical binding]; other site 698758004481 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698758004482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758004483 S-adenosylmethionine binding site [chemical binding]; other site 698758004484 short chain dehydrogenase; Provisional; Region: PRK06172 698758004485 classical (c) SDRs; Region: SDR_c; cd05233 698758004486 NAD(P) binding site [chemical binding]; other site 698758004487 active site 698758004488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698758004489 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698758004490 NAD(P) binding site [chemical binding]; other site 698758004491 active site 698758004492 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 698758004493 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 698758004494 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698758004495 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698758004496 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758004497 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758004498 alpha-galactosidase; Provisional; Region: PRK15076 698758004499 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 698758004500 NAD binding site [chemical binding]; other site 698758004501 sugar binding site [chemical binding]; other site 698758004502 divalent metal binding site [ion binding]; other site 698758004503 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 698758004504 dimer interface [polypeptide binding]; other site 698758004505 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698758004506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698758004507 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698758004508 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 698758004509 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 698758004510 NAD binding site [chemical binding]; other site 698758004511 substrate binding site [chemical binding]; other site 698758004512 catalytic Zn binding site [ion binding]; other site 698758004513 tetramer interface [polypeptide binding]; other site 698758004514 structural Zn binding site [ion binding]; other site 698758004515 Predicted flavoprotein [General function prediction only]; Region: COG0431 698758004516 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698758004517 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 698758004518 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698758004519 NADP binding site [chemical binding]; other site 698758004520 homodimer interface [polypeptide binding]; other site 698758004521 active site 698758004522 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 698758004523 dimer interface [polypeptide binding]; other site 698758004524 substrate binding site [chemical binding]; other site 698758004525 metal binding site [ion binding]; metal-binding site 698758004526 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 698758004527 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698758004528 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 698758004529 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 698758004530 HflX GTPase family; Region: HflX; cd01878 698758004531 G1 box; other site 698758004532 GTP/Mg2+ binding site [chemical binding]; other site 698758004533 Switch I region; other site 698758004534 G2 box; other site 698758004535 G3 box; other site 698758004536 Switch II region; other site 698758004537 G4 box; other site 698758004538 G5 box; other site 698758004539 stage V sporulation protein K; Region: spore_V_K; TIGR02881 698758004540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758004541 Walker A motif; other site 698758004542 ATP binding site [chemical binding]; other site 698758004543 Walker B motif; other site 698758004544 arginine finger; other site 698758004545 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 698758004546 bacterial Hfq-like; Region: Hfq; cd01716 698758004547 hexamer interface [polypeptide binding]; other site 698758004548 Sm1 motif; other site 698758004549 RNA binding site [nucleotide binding]; other site 698758004550 Sm2 motif; other site 698758004551 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 698758004552 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 698758004553 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 698758004554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758004555 ATP binding site [chemical binding]; other site 698758004556 Mg2+ binding site [ion binding]; other site 698758004557 G-X-G motif; other site 698758004558 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 698758004559 ATP binding site [chemical binding]; other site 698758004560 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 698758004561 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 698758004562 MutS domain I; Region: MutS_I; pfam01624 698758004563 MutS domain II; Region: MutS_II; pfam05188 698758004564 MutS domain III; Region: MutS_III; pfam05192 698758004565 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 698758004566 Walker A/P-loop; other site 698758004567 ATP binding site [chemical binding]; other site 698758004568 Q-loop/lid; other site 698758004569 ABC transporter signature motif; other site 698758004570 Walker B; other site 698758004571 D-loop; other site 698758004572 H-loop/switch region; other site 698758004573 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 698758004574 Outer spore coat protein E (CotE); Region: CotE; pfam10628 698758004575 Predicted membrane protein [Function unknown]; Region: COG4550 698758004576 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 698758004577 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 698758004578 active site 698758004579 dimer interface [polypeptide binding]; other site 698758004580 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 698758004581 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 698758004582 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698758004583 putative active site [active] 698758004584 metal binding site [ion binding]; metal-binding site 698758004585 homodimer binding site [polypeptide binding]; other site 698758004586 phosphodiesterase; Provisional; Region: PRK12704 698758004587 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698758004588 Zn2+ binding site [ion binding]; other site 698758004589 Mg2+ binding site [ion binding]; other site 698758004590 recombinase A; Provisional; Region: recA; PRK09354 698758004591 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 698758004592 hexamer interface [polypeptide binding]; other site 698758004593 Walker A motif; other site 698758004594 ATP binding site [chemical binding]; other site 698758004595 Walker B motif; other site 698758004596 competence damage-inducible protein A; Provisional; Region: PRK00549 698758004597 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 698758004598 putative MPT binding site; other site 698758004599 Competence-damaged protein; Region: CinA; pfam02464 698758004600 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 698758004601 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 698758004602 Helix-turn-helix domain; Region: HTH_25; pfam13413 698758004603 non-specific DNA binding site [nucleotide binding]; other site 698758004604 salt bridge; other site 698758004605 sequence-specific DNA binding site [nucleotide binding]; other site 698758004606 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 698758004607 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 698758004608 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 698758004609 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 698758004610 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 698758004611 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698758004612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698758004613 DNA-binding site [nucleotide binding]; DNA binding site 698758004614 UTRA domain; Region: UTRA; pfam07702 698758004615 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698758004616 Helix-turn-helix domain; Region: HTH_38; pfam13936 698758004617 Integrase core domain; Region: rve; pfam00665 698758004618 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698758004619 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 698758004620 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698758004621 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698758004622 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 698758004623 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698758004624 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698758004625 dimer interface [polypeptide binding]; other site 698758004626 active site 698758004627 catalytic residue [active] 698758004628 aspartate kinase I; Reviewed; Region: PRK08210 698758004629 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 698758004630 nucleotide binding site [chemical binding]; other site 698758004631 substrate binding site [chemical binding]; other site 698758004632 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 698758004633 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698758004634 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 698758004635 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698758004636 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 698758004637 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 698758004638 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 698758004639 NAD binding site [chemical binding]; other site 698758004640 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 698758004641 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698758004642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698758004643 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698758004644 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 698758004645 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 698758004646 RNase E interface [polypeptide binding]; other site 698758004647 trimer interface [polypeptide binding]; other site 698758004648 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 698758004649 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 698758004650 RNase E interface [polypeptide binding]; other site 698758004651 trimer interface [polypeptide binding]; other site 698758004652 active site 698758004653 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 698758004654 putative nucleic acid binding region [nucleotide binding]; other site 698758004655 G-X-X-G motif; other site 698758004656 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 698758004657 RNA binding site [nucleotide binding]; other site 698758004658 domain interface; other site 698758004659 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 698758004660 16S/18S rRNA binding site [nucleotide binding]; other site 698758004661 S13e-L30e interaction site [polypeptide binding]; other site 698758004662 25S rRNA binding site [nucleotide binding]; other site 698758004663 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 698758004664 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 698758004665 active site 698758004666 Riboflavin kinase; Region: Flavokinase; pfam01687 698758004667 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 698758004668 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 698758004669 RNA binding site [nucleotide binding]; other site 698758004670 active site 698758004671 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 698758004672 Protein of unknown function (DUF503); Region: DUF503; pfam04456 698758004673 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698758004674 translation initiation factor IF-2; Region: IF-2; TIGR00487 698758004675 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698758004676 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 698758004677 G1 box; other site 698758004678 putative GEF interaction site [polypeptide binding]; other site 698758004679 GTP/Mg2+ binding site [chemical binding]; other site 698758004680 Switch I region; other site 698758004681 G2 box; other site 698758004682 G3 box; other site 698758004683 Switch II region; other site 698758004684 G4 box; other site 698758004685 G5 box; other site 698758004686 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 698758004687 Translation-initiation factor 2; Region: IF-2; pfam11987 698758004688 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 698758004689 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 698758004690 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 698758004691 putative RNA binding cleft [nucleotide binding]; other site 698758004692 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 698758004693 NusA N-terminal domain; Region: NusA_N; pfam08529 698758004694 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 698758004695 RNA binding site [nucleotide binding]; other site 698758004696 homodimer interface [polypeptide binding]; other site 698758004697 NusA-like KH domain; Region: KH_5; pfam13184 698758004698 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698758004699 G-X-X-G motif; other site 698758004700 ribosome maturation protein RimP; Reviewed; Region: PRK00092 698758004701 Sm and related proteins; Region: Sm_like; cl00259 698758004702 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 698758004703 putative oligomer interface [polypeptide binding]; other site 698758004704 putative RNA binding site [nucleotide binding]; other site 698758004705 DNA polymerase III PolC; Validated; Region: polC; PRK00448 698758004706 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 698758004707 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 698758004708 generic binding surface II; other site 698758004709 generic binding surface I; other site 698758004710 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 698758004711 active site 698758004712 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698758004713 active site 698758004714 catalytic site [active] 698758004715 substrate binding site [chemical binding]; other site 698758004716 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 698758004717 prolyl-tRNA synthetase; Provisional; Region: PRK09194 698758004718 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 698758004719 dimer interface [polypeptide binding]; other site 698758004720 motif 1; other site 698758004721 active site 698758004722 motif 2; other site 698758004723 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 698758004724 putative deacylase active site [active] 698758004725 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698758004726 active site 698758004727 motif 3; other site 698758004728 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 698758004729 anticodon binding site; other site 698758004730 RIP metalloprotease RseP; Region: TIGR00054 698758004731 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698758004732 active site 698758004733 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 698758004734 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698758004735 protein binding site [polypeptide binding]; other site 698758004736 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698758004737 putative substrate binding region [chemical binding]; other site 698758004738 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 698758004739 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 698758004740 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698758004741 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 698758004742 catalytic residue [active] 698758004743 putative FPP diphosphate binding site; other site 698758004744 putative FPP binding hydrophobic cleft; other site 698758004745 dimer interface [polypeptide binding]; other site 698758004746 putative IPP diphosphate binding site; other site 698758004747 ribosome recycling factor; Reviewed; Region: frr; PRK00083 698758004748 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 698758004749 hinge region; other site 698758004750 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 698758004751 putative nucleotide binding site [chemical binding]; other site 698758004752 uridine monophosphate binding site [chemical binding]; other site 698758004753 homohexameric interface [polypeptide binding]; other site 698758004754 elongation factor Ts; Provisional; Region: tsf; PRK09377 698758004755 UBA/TS-N domain; Region: UBA; pfam00627 698758004756 Elongation factor TS; Region: EF_TS; pfam00889 698758004757 Elongation factor TS; Region: EF_TS; pfam00889 698758004758 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 698758004759 rRNA interaction site [nucleotide binding]; other site 698758004760 S8 interaction site; other site 698758004761 putative laminin-1 binding site; other site 698758004762 Protein of unknown function (DUF342); Region: DUF342; pfam03961 698758004763 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 698758004764 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698758004765 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698758004766 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698758004767 DNA binding residues [nucleotide binding] 698758004768 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 698758004769 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 698758004770 CheC-like family; Region: CheC; pfam04509 698758004771 CheC-like family; Region: CheC; pfam04509 698758004772 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 698758004773 putative CheA interaction surface; other site 698758004774 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 698758004775 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 698758004776 putative binding surface; other site 698758004777 active site 698758004778 P2 response regulator binding domain; Region: P2; pfam07194 698758004779 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 698758004780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758004781 ATP binding site [chemical binding]; other site 698758004782 Mg2+ binding site [ion binding]; other site 698758004783 G-X-G motif; other site 698758004784 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 698758004785 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 698758004786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758004787 active site 698758004788 phosphorylation site [posttranslational modification] 698758004789 intermolecular recognition site; other site 698758004790 dimerization interface [polypeptide binding]; other site 698758004791 CheB methylesterase; Region: CheB_methylest; pfam01339 698758004792 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698758004793 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 698758004794 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 698758004795 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 698758004796 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698758004797 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 698758004798 FHIPEP family; Region: FHIPEP; pfam00771 698758004799 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 698758004800 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 698758004801 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 698758004802 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 698758004803 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 698758004804 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 698758004805 Response regulator receiver domain; Region: Response_reg; pfam00072 698758004806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758004807 active site 698758004808 phosphorylation site [posttranslational modification] 698758004809 intermolecular recognition site; other site 698758004810 dimerization interface [polypeptide binding]; other site 698758004811 flagellar motor switch protein; Validated; Region: PRK08119 698758004812 CheC-like family; Region: CheC; pfam04509 698758004813 CheC-like family; Region: CheC; pfam04509 698758004814 flagellar motor switch protein FliN; Region: fliN; TIGR02480 698758004815 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 698758004816 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 698758004817 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 698758004818 Flagellar protein (FlbD); Region: FlbD; pfam06289 698758004819 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 698758004820 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 698758004821 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 698758004822 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 698758004823 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 698758004824 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 698758004825 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 698758004826 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 698758004827 Uncharacterized conserved protein [Function unknown]; Region: COG3334 698758004828 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 698758004829 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 698758004830 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 698758004831 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698758004832 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 698758004833 Walker A motif/ATP binding site; other site 698758004834 Walker B motif; other site 698758004835 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 698758004836 Flagellar assembly protein FliH; Region: FliH; pfam02108 698758004837 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 698758004838 MgtE intracellular N domain; Region: MgtE_N; smart00924 698758004839 FliG C-terminal domain; Region: FliG_C; pfam01706 698758004840 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 698758004841 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 698758004842 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 698758004843 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 698758004844 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 698758004845 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 698758004846 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 698758004847 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 698758004848 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 698758004849 transcriptional repressor CodY; Validated; Region: PRK04158 698758004850 CodY GAF-like domain; Region: CodY; pfam06018 698758004851 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 698758004852 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 698758004853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758004854 Walker A motif; other site 698758004855 ATP binding site [chemical binding]; other site 698758004856 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 698758004857 Walker B motif; other site 698758004858 arginine finger; other site 698758004859 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698758004860 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 698758004861 active site 698758004862 HslU subunit interaction site [polypeptide binding]; other site 698758004863 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698758004864 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 698758004865 active site 698758004866 Int/Topo IB signature motif; other site 698758004867 DNA topoisomerase I; Validated; Region: PRK05582 698758004868 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 698758004869 active site 698758004870 interdomain interaction site; other site 698758004871 putative metal-binding site [ion binding]; other site 698758004872 nucleotide binding site [chemical binding]; other site 698758004873 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698758004874 domain I; other site 698758004875 DNA binding groove [nucleotide binding] 698758004876 phosphate binding site [ion binding]; other site 698758004877 domain II; other site 698758004878 domain III; other site 698758004879 nucleotide binding site [chemical binding]; other site 698758004880 catalytic site [active] 698758004881 domain IV; other site 698758004882 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 698758004883 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 698758004884 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 698758004885 DNA protecting protein DprA; Region: dprA; TIGR00732 698758004886 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 698758004887 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 698758004888 RNA/DNA hybrid binding site [nucleotide binding]; other site 698758004889 active site 698758004890 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 698758004891 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 698758004892 GTP/Mg2+ binding site [chemical binding]; other site 698758004893 G4 box; other site 698758004894 G5 box; other site 698758004895 G1 box; other site 698758004896 Switch I region; other site 698758004897 G2 box; other site 698758004898 G3 box; other site 698758004899 Switch II region; other site 698758004900 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698758004901 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698758004902 Catalytic site [active] 698758004903 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698758004904 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 698758004905 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 698758004906 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 698758004907 RimM N-terminal domain; Region: RimM; pfam01782 698758004908 PRC-barrel domain; Region: PRC; pfam05239 698758004909 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 698758004910 KH domain; Region: KH_4; pfam13083 698758004911 G-X-X-G motif; other site 698758004912 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 698758004913 signal recognition particle protein; Provisional; Region: PRK10867 698758004914 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 698758004915 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698758004916 P loop; other site 698758004917 GTP binding site [chemical binding]; other site 698758004918 Signal peptide binding domain; Region: SRP_SPB; pfam02978 698758004919 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 698758004920 putative DNA-binding protein; Validated; Region: PRK00118 698758004921 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 698758004922 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 698758004923 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698758004924 P loop; other site 698758004925 GTP binding site [chemical binding]; other site 698758004926 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698758004927 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698758004928 Walker A/P-loop; other site 698758004929 ATP binding site [chemical binding]; other site 698758004930 Q-loop/lid; other site 698758004931 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 698758004932 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698758004933 ABC transporter signature motif; other site 698758004934 Walker B; other site 698758004935 D-loop; other site 698758004936 H-loop/switch region; other site 698758004937 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 698758004938 ribonuclease III; Reviewed; Region: rnc; PRK00102 698758004939 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698758004940 dimerization interface [polypeptide binding]; other site 698758004941 active site 698758004942 metal binding site [ion binding]; metal-binding site 698758004943 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 698758004944 dsRNA binding site [nucleotide binding]; other site 698758004945 acyl carrier protein; Provisional; Region: acpP; PRK00982 698758004946 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 698758004947 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 698758004948 NAD(P) binding site [chemical binding]; other site 698758004949 homotetramer interface [polypeptide binding]; other site 698758004950 homodimer interface [polypeptide binding]; other site 698758004951 active site 698758004952 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698758004953 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698758004954 putative phosphate acyltransferase; Provisional; Region: PRK05331 698758004955 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 698758004956 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 698758004957 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 698758004958 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 698758004959 generic binding surface II; other site 698758004960 ssDNA binding site; other site 698758004961 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698758004962 ATP binding site [chemical binding]; other site 698758004963 putative Mg++ binding site [ion binding]; other site 698758004964 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698758004965 nucleotide binding region [chemical binding]; other site 698758004966 ATP-binding site [chemical binding]; other site 698758004967 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 698758004968 DAK2 domain; Region: Dak2; pfam02734 698758004969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 698758004970 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 698758004971 Thiamine pyrophosphokinase; Region: TPK; cd07995 698758004972 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 698758004973 active site 698758004974 dimerization interface [polypeptide binding]; other site 698758004975 thiamine binding site [chemical binding]; other site 698758004976 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698758004977 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698758004978 substrate binding site [chemical binding]; other site 698758004979 hexamer interface [polypeptide binding]; other site 698758004980 metal binding site [ion binding]; metal-binding site 698758004981 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 698758004982 GTPase RsgA; Reviewed; Region: PRK00098 698758004983 RNA binding site [nucleotide binding]; other site 698758004984 homodimer interface [polypeptide binding]; other site 698758004985 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 698758004986 GTPase/Zn-binding domain interface [polypeptide binding]; other site 698758004987 GTP/Mg2+ binding site [chemical binding]; other site 698758004988 G4 box; other site 698758004989 G5 box; other site 698758004990 G1 box; other site 698758004991 Switch I region; other site 698758004992 G2 box; other site 698758004993 G3 box; other site 698758004994 Switch II region; other site 698758004995 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698758004996 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698758004997 active site 698758004998 ATP binding site [chemical binding]; other site 698758004999 substrate binding site [chemical binding]; other site 698758005000 activation loop (A-loop); other site 698758005001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698758005002 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 698758005003 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698758005004 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698758005005 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 698758005006 Protein phosphatase 2C; Region: PP2C; pfam00481 698758005007 active site 698758005008 NusB family; Region: NusB; pfam01029 698758005009 16S rRNA methyltransferase B; Provisional; Region: PRK14902 698758005010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758005011 S-adenosylmethionine binding site [chemical binding]; other site 698758005012 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 698758005013 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 698758005014 putative active site [active] 698758005015 substrate binding site [chemical binding]; other site 698758005016 putative cosubstrate binding site; other site 698758005017 catalytic site [active] 698758005018 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 698758005019 substrate binding site [chemical binding]; other site 698758005020 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698758005021 primosomal protein N' Region: priA; TIGR00595 698758005022 ATP binding site [chemical binding]; other site 698758005023 putative Mg++ binding site [ion binding]; other site 698758005024 helicase superfamily c-terminal domain; Region: HELICc; smart00490 698758005025 nucleotide binding region [chemical binding]; other site 698758005026 ATP-binding site [chemical binding]; other site 698758005027 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 698758005028 Flavoprotein; Region: Flavoprotein; pfam02441 698758005029 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 698758005030 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 698758005031 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698758005032 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 698758005033 catalytic site [active] 698758005034 G-X2-G-X-G-K; other site 698758005035 hypothetical protein; Provisional; Region: PRK04323 698758005036 hypothetical protein; Provisional; Region: PRK11820 698758005037 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 698758005038 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 698758005039 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 698758005040 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 698758005041 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698758005042 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 698758005043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758005044 motif II; other site 698758005045 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 698758005046 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 698758005047 Domain of unknown function (DUF814); Region: DUF814; pfam05670 698758005048 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 698758005049 active site 698758005050 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698758005051 active site 698758005052 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 698758005053 active site 698758005054 dimer interface [polypeptide binding]; other site 698758005055 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 698758005056 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 698758005057 heterodimer interface [polypeptide binding]; other site 698758005058 active site 698758005059 FMN binding site [chemical binding]; other site 698758005060 homodimer interface [polypeptide binding]; other site 698758005061 substrate binding site [chemical binding]; other site 698758005062 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 698758005063 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 698758005064 FAD binding pocket [chemical binding]; other site 698758005065 FAD binding motif [chemical binding]; other site 698758005066 phosphate binding motif [ion binding]; other site 698758005067 beta-alpha-beta structure motif; other site 698758005068 NAD binding pocket [chemical binding]; other site 698758005069 Iron coordination center [ion binding]; other site 698758005070 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698758005071 dihydroorotase; Validated; Region: pyrC; PRK09357 698758005072 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 698758005073 active site 698758005074 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 698758005075 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698758005076 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698758005077 uracil transporter; Provisional; Region: PRK10720 698758005078 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 698758005079 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698758005080 active site 698758005081 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698758005082 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698758005083 RNA binding surface [nucleotide binding]; other site 698758005084 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698758005085 active site 698758005086 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 698758005087 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 698758005088 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698758005089 active site 698758005090 HIGH motif; other site 698758005091 nucleotide binding site [chemical binding]; other site 698758005092 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698758005093 active site 698758005094 KMSKS motif; other site 698758005095 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 698758005096 tRNA binding surface [nucleotide binding]; other site 698758005097 anticodon binding site; other site 698758005098 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698758005099 DivIVA protein; Region: DivIVA; pfam05103 698758005100 DivIVA domain; Region: DivI1A_domain; TIGR03544 698758005101 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 698758005102 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 698758005103 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698758005104 RNA binding surface [nucleotide binding]; other site 698758005105 YGGT family; Region: YGGT; pfam02325 698758005106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 698758005107 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 698758005108 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698758005109 catalytic residue [active] 698758005110 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 698758005111 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 698758005112 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 698758005113 sporulation sigma factor SigG; Reviewed; Region: PRK08215 698758005114 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698758005115 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698758005116 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698758005117 DNA binding residues [nucleotide binding] 698758005118 sporulation sigma factor SigE; Reviewed; Region: PRK08301 698758005119 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698758005120 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698758005121 DNA binding residues [nucleotide binding] 698758005122 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 698758005123 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 698758005124 cell division protein FtsZ; Validated; Region: PRK09330 698758005125 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698758005126 nucleotide binding site [chemical binding]; other site 698758005127 SulA interaction site; other site 698758005128 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 698758005129 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698758005130 nucleotide binding site [chemical binding]; other site 698758005131 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 698758005132 Cell division protein FtsA; Region: FtsA; pfam14450 698758005133 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 698758005134 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 698758005135 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 698758005136 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 698758005137 Cell division protein FtsQ; Region: FtsQ; pfam03799 698758005138 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698758005139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698758005140 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698758005141 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698758005142 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698758005143 Walker A/P-loop; other site 698758005144 ATP binding site [chemical binding]; other site 698758005145 Q-loop/lid; other site 698758005146 ABC transporter signature motif; other site 698758005147 Walker B; other site 698758005148 D-loop; other site 698758005149 H-loop/switch region; other site 698758005150 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698758005151 FtsX-like permease family; Region: FtsX; pfam02687 698758005152 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 698758005153 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 698758005154 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698758005155 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698758005156 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 698758005157 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 698758005158 Mg++ binding site [ion binding]; other site 698758005159 putative catalytic motif [active] 698758005160 putative substrate binding site [chemical binding]; other site 698758005161 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 698758005162 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698758005163 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698758005164 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698758005165 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 698758005166 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698758005167 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698758005168 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698758005169 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 698758005170 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698758005171 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698758005172 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 698758005173 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698758005174 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698758005175 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698758005176 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 698758005177 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 698758005178 Cell division protein FtsL; Region: FtsL; cl11433 698758005179 MraW methylase family; Region: Methyltransf_5; pfam01795 698758005180 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 698758005181 cell division protein MraZ; Reviewed; Region: PRK00326 698758005182 MraZ protein; Region: MraZ; pfam02381 698758005183 MraZ protein; Region: MraZ; pfam02381 698758005184 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 698758005185 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 698758005186 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 698758005187 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 698758005188 hypothetical protein; Provisional; Region: PRK13670 698758005189 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 698758005190 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 698758005191 protein binding site [polypeptide binding]; other site 698758005192 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 698758005193 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 698758005194 Nucleoside recognition; Region: Gate; pfam07670 698758005195 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 698758005196 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 698758005197 active site 698758005198 (T/H)XGH motif; other site 698758005199 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 698758005200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758005201 S-adenosylmethionine binding site [chemical binding]; other site 698758005202 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 698758005203 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 698758005204 Putative coat protein; Region: YlbD_coat; pfam14071 698758005205 FOG: CBS domain [General function prediction only]; Region: COG0517 698758005206 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 698758005207 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698758005208 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 698758005209 hypothetical protein; Provisional; Region: PRK13666 698758005210 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 698758005211 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698758005212 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698758005213 active site 698758005214 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 698758005215 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 698758005216 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698758005217 NodB motif; other site 698758005218 active site 698758005219 catalytic site [active] 698758005220 metal binding site [ion binding]; metal-binding site 698758005221 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 698758005222 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698758005223 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698758005224 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 698758005225 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698758005226 E3 interaction surface; other site 698758005227 lipoyl attachment site [posttranslational modification]; other site 698758005228 e3 binding domain; Region: E3_binding; pfam02817 698758005229 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698758005230 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 698758005231 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 698758005232 alpha subunit interface [polypeptide binding]; other site 698758005233 TPP binding site [chemical binding]; other site 698758005234 heterodimer interface [polypeptide binding]; other site 698758005235 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698758005236 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 698758005237 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 698758005238 TPP-binding site [chemical binding]; other site 698758005239 tetramer interface [polypeptide binding]; other site 698758005240 heterodimer interface [polypeptide binding]; other site 698758005241 phosphorylation loop region [posttranslational modification] 698758005242 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 698758005243 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698758005244 active site 698758005245 catalytic residues [active] 698758005246 metal binding site [ion binding]; metal-binding site 698758005247 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 698758005248 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698758005249 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 698758005250 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698758005251 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698758005252 TrkA-N domain; Region: TrkA_N; pfam02254 698758005253 TrkA-C domain; Region: TrkA_C; pfam02080 698758005254 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698758005255 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698758005256 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 698758005257 Walker A/P-loop; other site 698758005258 ATP binding site [chemical binding]; other site 698758005259 Q-loop/lid; other site 698758005260 ABC transporter signature motif; other site 698758005261 Walker B; other site 698758005262 D-loop; other site 698758005263 H-loop/switch region; other site 698758005264 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698758005265 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698758005266 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 698758005267 Walker A/P-loop; other site 698758005268 ATP binding site [chemical binding]; other site 698758005269 Q-loop/lid; other site 698758005270 ABC transporter signature motif; other site 698758005271 Walker B; other site 698758005272 D-loop; other site 698758005273 H-loop/switch region; other site 698758005274 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698758005275 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698758005276 FOG: CBS domain [General function prediction only]; Region: COG0517 698758005277 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 698758005278 YkyB-like protein; Region: YkyB; pfam14177 698758005279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 698758005280 Integrase core domain; Region: rve; pfam00665 698758005281 transposase/IS protein; Provisional; Region: PRK09183 698758005282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698758005283 Walker A motif; other site 698758005284 ATP binding site [chemical binding]; other site 698758005285 Walker B motif; other site 698758005286 arginine finger; other site 698758005287 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 698758005288 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698758005289 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698758005290 Catalytic site [active] 698758005291 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698758005292 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 698758005293 stage V sporulation protein AD; Provisional; Region: PRK12404 698758005294 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 698758005295 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 698758005296 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698758005297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698758005298 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698758005299 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 698758005300 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 698758005301 active site 698758005302 Zn binding site [ion binding]; other site 698758005303 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 698758005304 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698758005305 PYR/PP interface [polypeptide binding]; other site 698758005306 dimer interface [polypeptide binding]; other site 698758005307 TPP binding site [chemical binding]; other site 698758005308 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698758005309 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 698758005310 TPP-binding site [chemical binding]; other site 698758005311 dimer interface [polypeptide binding]; other site 698758005312 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 698758005313 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 698758005314 putative valine binding site [chemical binding]; other site 698758005315 dimer interface [polypeptide binding]; other site 698758005316 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 698758005317 ketol-acid reductoisomerase; Provisional; Region: PRK05479 698758005318 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 698758005319 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 698758005320 2-isopropylmalate synthase; Validated; Region: PRK00915 698758005321 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 698758005322 active site 698758005323 catalytic residues [active] 698758005324 metal binding site [ion binding]; metal-binding site 698758005325 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 698758005326 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 698758005327 tartrate dehydrogenase; Region: TTC; TIGR02089 698758005328 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 698758005329 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 698758005330 substrate binding site [chemical binding]; other site 698758005331 ligand binding site [chemical binding]; other site 698758005332 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 698758005333 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 698758005334 substrate binding site [chemical binding]; other site 698758005335 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698758005336 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698758005337 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698758005338 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 698758005339 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 698758005340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698758005341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698758005342 DNA binding residues [nucleotide binding] 698758005343 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698758005344 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698758005345 Walker A/P-loop; other site 698758005346 ATP binding site [chemical binding]; other site 698758005347 Q-loop/lid; other site 698758005348 ABC transporter signature motif; other site 698758005349 Walker B; other site 698758005350 D-loop; other site 698758005351 H-loop/switch region; other site 698758005352 Predicted transcriptional regulators [Transcription]; Region: COG1725 698758005353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698758005354 DNA-binding site [nucleotide binding]; DNA binding site 698758005355 Predicted esterase [General function prediction only]; Region: COG0400 698758005356 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698758005357 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 698758005358 Protein of unknown function DUF58; Region: DUF58; pfam01882 698758005359 MoxR-like ATPases [General function prediction only]; Region: COG0714 698758005360 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 698758005361 Thioredoxin; Region: Thioredoxin_4; cl17273 698758005362 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 698758005363 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 698758005364 Sporulation inhibitor A; Region: Sda; pfam08970 698758005365 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698758005366 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 698758005367 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698758005368 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698758005369 Walker A/P-loop; other site 698758005370 ATP binding site [chemical binding]; other site 698758005371 Q-loop/lid; other site 698758005372 ABC transporter signature motif; other site 698758005373 Walker B; other site 698758005374 D-loop; other site 698758005375 H-loop/switch region; other site 698758005376 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698758005377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758005378 dimer interface [polypeptide binding]; other site 698758005379 conserved gate region; other site 698758005380 putative PBP binding loops; other site 698758005381 ABC-ATPase subunit interface; other site 698758005382 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698758005383 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698758005384 substrate binding pocket [chemical binding]; other site 698758005385 membrane-bound complex binding site; other site 698758005386 hinge residues; other site 698758005387 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758005388 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698758005389 active site 698758005390 motif I; other site 698758005391 motif II; other site 698758005392 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698758005393 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 698758005394 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 698758005395 YvrJ protein family; Region: YvrJ; pfam12841 698758005396 Homoserine O-succinyltransferase; Region: HTS; pfam04204 698758005397 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 698758005398 proposed active site lysine [active] 698758005399 conserved cys residue [active] 698758005400 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 698758005401 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 698758005402 gamma subunit interface [polypeptide binding]; other site 698758005403 epsilon subunit interface [polypeptide binding]; other site 698758005404 LBP interface [polypeptide binding]; other site 698758005405 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 698758005406 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698758005407 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 698758005408 alpha subunit interaction interface [polypeptide binding]; other site 698758005409 Walker A motif; other site 698758005410 ATP binding site [chemical binding]; other site 698758005411 Walker B motif; other site 698758005412 inhibitor binding site; inhibition site 698758005413 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698758005414 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 698758005415 core domain interface [polypeptide binding]; other site 698758005416 delta subunit interface [polypeptide binding]; other site 698758005417 epsilon subunit interface [polypeptide binding]; other site 698758005418 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 698758005419 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698758005420 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 698758005421 beta subunit interaction interface [polypeptide binding]; other site 698758005422 Walker A motif; other site 698758005423 ATP binding site [chemical binding]; other site 698758005424 Walker B motif; other site 698758005425 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698758005426 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 698758005427 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 698758005428 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 698758005429 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 698758005430 ATP synthase subunit C; Region: ATP-synt_C; cl00466 698758005431 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 698758005432 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 698758005433 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 698758005434 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 698758005435 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698758005436 DNA-binding site [nucleotide binding]; DNA binding site 698758005437 RNA-binding motif; other site 698758005438 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 698758005439 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 698758005440 Predicted membrane protein [Function unknown]; Region: COG3212 698758005441 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 698758005442 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698758005443 HAMP domain; Region: HAMP; pfam00672 698758005444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698758005445 dimer interface [polypeptide binding]; other site 698758005446 phosphorylation site [posttranslational modification] 698758005447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758005448 ATP binding site [chemical binding]; other site 698758005449 Mg2+ binding site [ion binding]; other site 698758005450 G-X-G motif; other site 698758005451 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698758005452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758005453 active site 698758005454 phosphorylation site [posttranslational modification] 698758005455 intermolecular recognition site; other site 698758005456 dimerization interface [polypeptide binding]; other site 698758005457 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698758005458 DNA binding site [nucleotide binding] 698758005459 S-formylglutathione hydrolase; Region: PLN02442 698758005460 Putative esterase; Region: Esterase; pfam00756 698758005461 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698758005462 active site 698758005463 DNA binding site [nucleotide binding] 698758005464 Int/Topo IB signature motif; other site 698758005465 Membrane transport protein; Region: Mem_trans; cl09117 698758005466 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 698758005467 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758005468 active site 698758005469 motif I; other site 698758005470 motif II; other site 698758005471 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698758005472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758005473 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698758005474 active site 698758005475 motif I; other site 698758005476 motif II; other site 698758005477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758005478 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 698758005479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758005480 active site 698758005481 phosphorylation site [posttranslational modification] 698758005482 intermolecular recognition site; other site 698758005483 dimerization interface [polypeptide binding]; other site 698758005484 beta-phosphoglucomutase; Region: bPGM; TIGR01990 698758005485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758005486 maltose phosphorylase; Provisional; Region: PRK13807 698758005487 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 698758005488 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 698758005489 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 698758005490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 698758005491 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698758005492 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 698758005493 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 698758005494 dimerization interface [polypeptide binding]; other site 698758005495 DPS ferroxidase diiron center [ion binding]; other site 698758005496 ion pore; other site 698758005497 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698758005498 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698758005499 catalytic residues [active] 698758005500 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698758005501 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 698758005502 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698758005503 catalytic residues [active] 698758005504 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698758005505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758005506 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 698758005507 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 698758005508 active site 698758005509 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698758005510 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 698758005511 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 698758005512 active site 698758005513 CAAX protease self-immunity; Region: Abi; pfam02517 698758005514 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 698758005515 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 698758005516 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698758005517 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 698758005518 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 698758005519 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698758005520 putative active site [active] 698758005521 putative metal binding site [ion binding]; other site 698758005522 Predicted transcriptional regulators [Transcription]; Region: COG1695 698758005523 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 698758005524 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 698758005525 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 698758005526 putative oligomer interface [polypeptide binding]; other site 698758005527 putative active site [active] 698758005528 metal binding site [ion binding]; metal-binding site 698758005529 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698758005530 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698758005531 Walker A/P-loop; other site 698758005532 ATP binding site [chemical binding]; other site 698758005533 Q-loop/lid; other site 698758005534 ABC transporter signature motif; other site 698758005535 Walker B; other site 698758005536 D-loop; other site 698758005537 H-loop/switch region; other site 698758005538 Helix-turn-helix domain; Region: HTH_17; cl17695 698758005539 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698758005540 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 698758005541 RNA binding surface [nucleotide binding]; other site 698758005542 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698758005543 active site 698758005544 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 698758005545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698758005546 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698758005547 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698758005548 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 698758005549 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698758005550 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698758005551 non-specific DNA binding site [nucleotide binding]; other site 698758005552 salt bridge; other site 698758005553 sequence-specific DNA binding site [nucleotide binding]; other site 698758005554 transcriptional antiterminator BglG; Provisional; Region: PRK09772 698758005555 CAT RNA binding domain; Region: CAT_RBD; smart01061 698758005556 PRD domain; Region: PRD; pfam00874 698758005557 PRD domain; Region: PRD; pfam00874 698758005558 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 698758005559 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698758005560 active site turn [active] 698758005561 phosphorylation site [posttranslational modification] 698758005562 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698758005563 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 698758005564 HPr interaction site; other site 698758005565 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698758005566 active site 698758005567 phosphorylation site [posttranslational modification] 698758005568 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 698758005569 beta-galactosidase; Region: BGL; TIGR03356 698758005570 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698758005571 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698758005572 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 698758005573 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 698758005574 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 698758005575 Ca binding site [ion binding]; other site 698758005576 carbohydrate binding site [chemical binding]; other site 698758005577 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 698758005578 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 698758005579 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 698758005580 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 698758005581 Ca binding site [ion binding]; other site 698758005582 carbohydrate binding site [chemical binding]; other site 698758005583 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cd00890 698758005584 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698758005585 5'-3' exonuclease; Region: 53EXOc; smart00475 698758005586 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698758005587 active site 698758005588 metal binding site 1 [ion binding]; metal-binding site 698758005589 putative 5' ssDNA interaction site; other site 698758005590 metal binding site 3; metal-binding site 698758005591 metal binding site 2 [ion binding]; metal-binding site 698758005592 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698758005593 putative DNA binding site [nucleotide binding]; other site 698758005594 putative metal binding site [ion binding]; other site 698758005595 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 698758005596 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 698758005597 Ca binding site [ion binding]; other site 698758005598 active site 698758005599 catalytic site [active] 698758005600 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 698758005601 carbohydrate binding site [chemical binding]; other site 698758005602 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 698758005603 carbohydrate binding site [chemical binding]; other site 698758005604 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 698758005605 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698758005606 active site 698758005607 catalytic site [active] 698758005608 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 698758005609 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 698758005610 carbohydrate binding site [chemical binding]; other site 698758005611 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 698758005612 carbohydrate binding site [chemical binding]; other site 698758005613 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 698758005614 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 698758005615 Ca binding site [ion binding]; other site 698758005616 active site 698758005617 catalytic site [active] 698758005618 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 698758005619 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 698758005620 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 698758005621 Ca binding site [ion binding]; other site 698758005622 active site 698758005623 catalytic site [active] 698758005624 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698758005625 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 698758005626 active site 698758005627 catalytic site [active] 698758005628 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 698758005629 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 698758005630 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698758005631 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698758005632 metal binding site [ion binding]; metal-binding site 698758005633 active site 698758005634 I-site; other site 698758005635 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698758005636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758005637 dimer interface [polypeptide binding]; other site 698758005638 conserved gate region; other site 698758005639 putative PBP binding loops; other site 698758005640 ABC-ATPase subunit interface; other site 698758005641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758005642 dimer interface [polypeptide binding]; other site 698758005643 conserved gate region; other site 698758005644 ABC-ATPase subunit interface; other site 698758005645 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698758005646 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698758005647 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 698758005648 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698758005649 dimer interface [polypeptide binding]; other site 698758005650 putative CheW interface [polypeptide binding]; other site 698758005651 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698758005652 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698758005653 DNA binding site [nucleotide binding] 698758005654 domain linker motif; other site 698758005655 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 698758005656 putative dimerization interface [polypeptide binding]; other site 698758005657 putative ligand binding site [chemical binding]; other site 698758005658 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 698758005659 homodimer interface [polypeptide binding]; other site 698758005660 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 698758005661 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698758005662 active site 698758005663 homodimer interface [polypeptide binding]; other site 698758005664 catalytic site [active] 698758005665 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698758005666 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 698758005667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758005668 Walker A/P-loop; other site 698758005669 ATP binding site [chemical binding]; other site 698758005670 Q-loop/lid; other site 698758005671 ABC transporter signature motif; other site 698758005672 Walker B; other site 698758005673 D-loop; other site 698758005674 H-loop/switch region; other site 698758005675 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698758005676 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 698758005677 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 698758005678 Walker A/P-loop; other site 698758005679 ATP binding site [chemical binding]; other site 698758005680 Q-loop/lid; other site 698758005681 ABC transporter signature motif; other site 698758005682 Walker B; other site 698758005683 D-loop; other site 698758005684 H-loop/switch region; other site 698758005685 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 698758005686 putative ligand binding site [chemical binding]; other site 698758005687 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 698758005688 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 698758005689 dimerization interface [polypeptide binding]; other site 698758005690 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698758005691 ligand binding site [chemical binding]; other site 698758005692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 698758005693 PAS domain S-box; Region: sensory_box; TIGR00229 698758005694 putative active site [active] 698758005695 heme pocket [chemical binding]; other site 698758005696 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698758005697 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698758005698 metal binding site [ion binding]; metal-binding site 698758005699 active site 698758005700 I-site; other site 698758005701 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698758005702 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698758005703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698758005704 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698758005705 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698758005706 classical (c) SDRs; Region: SDR_c; cd05233 698758005707 NAD(P) binding site [chemical binding]; other site 698758005708 active site 698758005709 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 698758005710 putative efflux protein, MATE family; Region: matE; TIGR00797 698758005711 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698758005712 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698758005713 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698758005714 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 698758005715 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 698758005716 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 698758005717 inhibitor binding site; inhibition site 698758005718 active site 698758005719 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 698758005720 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 698758005721 Metal-binding active site; metal-binding site 698758005722 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 698758005723 active site 698758005724 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 698758005725 Domain of unknown function (DUF368); Region: DUF368; pfam04018 698758005726 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698758005727 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698758005728 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 698758005729 Walker A/P-loop; other site 698758005730 ATP binding site [chemical binding]; other site 698758005731 Q-loop/lid; other site 698758005732 ABC transporter signature motif; other site 698758005733 Walker B; other site 698758005734 D-loop; other site 698758005735 H-loop/switch region; other site 698758005736 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698758005737 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 698758005738 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 698758005739 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 698758005740 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 698758005741 Spore germination protein; Region: Spore_permease; cl17796 698758005742 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 698758005743 cell division protein FtsW; Region: ftsW; TIGR02614 698758005744 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 698758005745 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698758005746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698758005747 Coenzyme A binding pocket [chemical binding]; other site 698758005748 Predicted membrane protein [Function unknown]; Region: COG2323 698758005749 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 698758005750 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 698758005751 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 698758005752 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 698758005753 NAD binding site [chemical binding]; other site 698758005754 homotetramer interface [polypeptide binding]; other site 698758005755 homodimer interface [polypeptide binding]; other site 698758005756 substrate binding site [chemical binding]; other site 698758005757 active site 698758005758 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698758005759 MgtE intracellular N domain; Region: MgtE_N; pfam03448 698758005760 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698758005761 Divalent cation transporter; Region: MgtE; pfam01769 698758005762 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 698758005763 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698758005764 active site 698758005765 metal binding site [ion binding]; metal-binding site 698758005766 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698758005767 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698758005768 active site 698758005769 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 698758005770 ATP-NAD kinase; Region: NAD_kinase; pfam01513 698758005771 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698758005772 synthetase active site [active] 698758005773 NTP binding site [chemical binding]; other site 698758005774 metal binding site [ion binding]; metal-binding site 698758005775 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 698758005776 putative active site [active] 698758005777 putative metal binding residues [ion binding]; other site 698758005778 signature motif; other site 698758005779 putative triphosphate binding site [ion binding]; other site 698758005780 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 698758005781 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 698758005782 catalytic residues [active] 698758005783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698758005784 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698758005785 putative substrate translocation pore; other site 698758005786 oligoendopeptidase F; Region: pepF; TIGR00181 698758005787 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 698758005788 active site 698758005789 Zn binding site [ion binding]; other site 698758005790 Competence protein CoiA-like family; Region: CoiA; cl11541 698758005791 adaptor protein; Provisional; Region: PRK02315 698758005792 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 698758005793 ArsC family; Region: ArsC; pfam03960 698758005794 putative catalytic residues [active] 698758005795 thiol/disulfide switch; other site 698758005796 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 698758005797 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 698758005798 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698758005799 peptide binding site [polypeptide binding]; other site 698758005800 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698758005801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758005802 dimer interface [polypeptide binding]; other site 698758005803 conserved gate region; other site 698758005804 ABC-ATPase subunit interface; other site 698758005805 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698758005806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758005807 dimer interface [polypeptide binding]; other site 698758005808 conserved gate region; other site 698758005809 putative PBP binding loops; other site 698758005810 ABC-ATPase subunit interface; other site 698758005811 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698758005812 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698758005813 Walker A/P-loop; other site 698758005814 ATP binding site [chemical binding]; other site 698758005815 Q-loop/lid; other site 698758005816 ABC transporter signature motif; other site 698758005817 Walker B; other site 698758005818 D-loop; other site 698758005819 H-loop/switch region; other site 698758005820 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698758005821 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698758005822 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698758005823 Walker A/P-loop; other site 698758005824 ATP binding site [chemical binding]; other site 698758005825 Q-loop/lid; other site 698758005826 ABC transporter signature motif; other site 698758005827 Walker B; other site 698758005828 D-loop; other site 698758005829 H-loop/switch region; other site 698758005830 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 698758005831 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 698758005832 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 698758005833 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698758005834 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698758005835 active site 698758005836 HIGH motif; other site 698758005837 dimer interface [polypeptide binding]; other site 698758005838 KMSKS motif; other site 698758005839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 698758005840 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698758005841 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 698758005842 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 698758005843 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 698758005844 dimer interface [polypeptide binding]; other site 698758005845 active site 698758005846 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 698758005847 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 698758005848 dimer interface [polypeptide binding]; other site 698758005849 active site 698758005850 CoA binding pocket [chemical binding]; other site 698758005851 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698758005852 Helix-turn-helix domain; Region: HTH_38; pfam13936 698758005853 Integrase core domain; Region: rve; pfam00665 698758005854 Integrase core domain; Region: rve_3; cl15866 698758005855 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 698758005856 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698758005857 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 698758005858 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698758005859 putative switch regulator; other site 698758005860 non-specific DNA interactions [nucleotide binding]; other site 698758005861 DNA binding site [nucleotide binding] 698758005862 sequence specific DNA binding site [nucleotide binding]; other site 698758005863 putative cAMP binding site [chemical binding]; other site 698758005864 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 698758005865 esterase; Provisional; Region: PRK10566 698758005866 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698758005867 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758005868 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698758005869 active site 698758005870 motif I; other site 698758005871 motif II; other site 698758005872 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758005873 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 698758005874 Uncharacterized conserved protein [Function unknown]; Region: COG1284 698758005875 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 698758005876 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 698758005877 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 698758005878 EDD domain protein, DegV family; Region: DegV; TIGR00762 698758005879 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698758005880 hypothetical protein; Provisional; Region: PRK13673 698758005881 Prefoldin subunit; Region: Prefoldin_2; pfam01920 698758005882 NlpC/P60 family; Region: NLPC_P60; pfam00877 698758005883 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 698758005884 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 698758005885 active site 698758005886 catalytic residue [active] 698758005887 dimer interface [polypeptide binding]; other site 698758005888 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 698758005889 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 698758005890 substrate binding [chemical binding]; other site 698758005891 active site 698758005892 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 698758005893 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 698758005894 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698758005895 active site turn [active] 698758005896 phosphorylation site [posttranslational modification] 698758005897 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698758005898 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 698758005899 Collagen binding domain; Region: Collagen_bind; pfam05737 698758005900 Collagen binding domain; Region: Collagen_bind; pfam05737 698758005901 Collagen binding domain; Region: Collagen_bind; pfam05737 698758005902 Collagen binding domain; Region: Collagen_bind; pfam05737 698758005903 Cna protein B-type domain; Region: Cna_B; pfam05738 698758005904 Cna protein B-type domain; Region: Cna_B; pfam05738 698758005905 Cna protein B-type domain; Region: Cna_B; pfam05738 698758005906 Cna protein B-type domain; Region: Cna_B; pfam05738 698758005907 Cna protein B-type domain; Region: Cna_B; pfam05738 698758005908 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 698758005909 domain interaction interfaces [polypeptide binding]; other site 698758005910 Cna protein B-type domain; Region: Cna_B; pfam05738 698758005911 Cna protein B-type domain; Region: Cna_B; pfam05738 698758005912 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 698758005913 domain interaction interfaces [polypeptide binding]; other site 698758005914 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 698758005915 domain interaction interfaces [polypeptide binding]; other site 698758005916 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 698758005917 domain interaction interfaces [polypeptide binding]; other site 698758005918 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 698758005919 domain interaction interfaces [polypeptide binding]; other site 698758005920 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 698758005921 domain interaction interfaces [polypeptide binding]; other site 698758005922 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 698758005923 domain interaction interfaces [polypeptide binding]; other site 698758005924 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 698758005925 domain interaction interfaces [polypeptide binding]; other site 698758005926 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 698758005927 domain interaction interfaces [polypeptide binding]; other site 698758005928 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 698758005929 domain interaction interfaces [polypeptide binding]; other site 698758005930 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 698758005931 domain interaction interfaces [polypeptide binding]; other site 698758005932 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 698758005933 domain interaction interfaces [polypeptide binding]; other site 698758005934 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698758005935 Integrase core domain; Region: rve; pfam00665 698758005936 Integrase core domain; Region: rve_3; cl15866 698758005937 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 698758005938 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 698758005939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698758005940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698758005941 dimer interface [polypeptide binding]; other site 698758005942 phosphorylation site [posttranslational modification] 698758005943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758005944 ATP binding site [chemical binding]; other site 698758005945 Mg2+ binding site [ion binding]; other site 698758005946 G-X-G motif; other site 698758005947 Response regulator receiver domain; Region: Response_reg; pfam00072 698758005948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758005949 active site 698758005950 phosphorylation site [posttranslational modification] 698758005951 intermolecular recognition site; other site 698758005952 dimerization interface [polypeptide binding]; other site 698758005953 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 698758005954 Histidine kinase; Region: His_kinase; pfam06580 698758005955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758005956 ATP binding site [chemical binding]; other site 698758005957 Mg2+ binding site [ion binding]; other site 698758005958 G-X-G motif; other site 698758005959 Response regulator receiver domain; Region: Response_reg; pfam00072 698758005960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758005961 active site 698758005962 phosphorylation site [posttranslational modification] 698758005963 intermolecular recognition site; other site 698758005964 dimerization interface [polypeptide binding]; other site 698758005965 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 698758005966 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 698758005967 SmpB-tmRNA interface; other site 698758005968 ribonuclease R; Region: RNase_R; TIGR02063 698758005969 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 698758005970 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698758005971 RNB domain; Region: RNB; pfam00773 698758005972 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 698758005973 RNA binding site [nucleotide binding]; other site 698758005974 Esterase/lipase [General function prediction only]; Region: COG1647 698758005975 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698758005976 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 698758005977 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698758005978 dimerization domain swap beta strand [polypeptide binding]; other site 698758005979 regulatory protein interface [polypeptide binding]; other site 698758005980 active site 698758005981 regulatory phosphorylation site [posttranslational modification]; other site 698758005982 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 698758005983 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 698758005984 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698758005985 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698758005986 enolase; Provisional; Region: eno; PRK00077 698758005987 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 698758005988 dimer interface [polypeptide binding]; other site 698758005989 metal binding site [ion binding]; metal-binding site 698758005990 substrate binding pocket [chemical binding]; other site 698758005991 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 698758005992 phosphoglyceromutase; Provisional; Region: PRK05434 698758005993 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698758005994 triosephosphate isomerase; Provisional; Region: PRK14565 698758005995 substrate binding site [chemical binding]; other site 698758005996 dimer interface [polypeptide binding]; other site 698758005997 catalytic triad [active] 698758005998 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 698758005999 Phosphoglycerate kinase; Region: PGK; pfam00162 698758006000 substrate binding site [chemical binding]; other site 698758006001 hinge regions; other site 698758006002 ADP binding site [chemical binding]; other site 698758006003 catalytic site [active] 698758006004 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 698758006005 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 698758006006 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698758006007 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698758006008 Predicted transcriptional regulator [Transcription]; Region: COG3388 698758006009 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698758006010 Clp protease; Region: CLP_protease; pfam00574 698758006011 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698758006012 oligomer interface [polypeptide binding]; other site 698758006013 active site residues [active] 698758006014 hypothetical protein; Provisional; Region: PRK13676 698758006015 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 698758006016 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 698758006017 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698758006018 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698758006019 Walker A/P-loop; other site 698758006020 ATP binding site [chemical binding]; other site 698758006021 Q-loop/lid; other site 698758006022 ABC transporter signature motif; other site 698758006023 Walker B; other site 698758006024 D-loop; other site 698758006025 H-loop/switch region; other site 698758006026 TOBE domain; Region: TOBE_2; pfam08402 698758006027 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 698758006028 fumarate hydratase; Reviewed; Region: fumC; PRK00485 698758006029 Class II fumarases; Region: Fumarase_classII; cd01362 698758006030 active site 698758006031 tetramer interface [polypeptide binding]; other site 698758006032 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 698758006033 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 698758006034 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 698758006035 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 698758006036 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 698758006037 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698758006038 active site 698758006039 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 698758006040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 698758006041 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698758006042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758006043 short chain dehydrogenase; Provisional; Region: PRK06924 698758006044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698758006045 NAD(P) binding site [chemical binding]; other site 698758006046 active site 698758006047 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698758006048 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698758006049 intersubunit interface [polypeptide binding]; other site 698758006050 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698758006051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698758006052 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698758006053 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 698758006054 putative homodimer interface [polypeptide binding]; other site 698758006055 putative homotetramer interface [polypeptide binding]; other site 698758006056 putative metal binding site [ion binding]; other site 698758006057 putative homodimer-homodimer interface [polypeptide binding]; other site 698758006058 putative allosteric switch controlling residues; other site 698758006059 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 698758006060 active site residue [active] 698758006061 hypothetical protein; Provisional; Region: PRK08201 698758006062 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 698758006063 metal binding site [ion binding]; metal-binding site 698758006064 putative dimer interface [polypeptide binding]; other site 698758006065 S-ribosylhomocysteinase; Provisional; Region: PRK02260 698758006066 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 698758006067 YhdB-like protein; Region: YhdB; pfam14148 698758006068 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 698758006069 active site clefts [active] 698758006070 zinc binding site [ion binding]; other site 698758006071 dimer interface [polypeptide binding]; other site 698758006072 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 698758006073 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 698758006074 active site 698758006075 homodimer interface [polypeptide binding]; other site 698758006076 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 698758006077 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 698758006078 Putative amidase domain; Region: Amidase_6; pfam12671 698758006079 epoxyqueuosine reductase; Region: TIGR00276 698758006080 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 698758006081 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698758006082 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698758006083 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 698758006084 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 698758006085 active site 698758006086 catalytic triad [active] 698758006087 oxyanion hole [active] 698758006088 PAS fold; Region: PAS_4; pfam08448 698758006089 PAS domain; Region: PAS_9; pfam13426 698758006090 PAS domain S-box; Region: sensory_box; TIGR00229 698758006091 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698758006092 putative active site [active] 698758006093 heme pocket [chemical binding]; other site 698758006094 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698758006095 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698758006096 metal binding site [ion binding]; metal-binding site 698758006097 active site 698758006098 I-site; other site 698758006099 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 698758006100 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 698758006101 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698758006102 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 698758006103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758006104 motif II; other site 698758006105 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 698758006106 Putative motility protein; Region: YjfB_motility; pfam14070 698758006107 flagellin; Provisional; Region: PRK12804 698758006108 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 698758006109 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 698758006110 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 698758006111 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698758006112 metal ion-dependent adhesion site (MIDAS); other site 698758006113 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 698758006114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 698758006115 binding surface 698758006116 TPR motif; other site 698758006117 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 698758006118 HNH endonuclease; Region: HNH_2; pfam13391 698758006119 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 698758006120 flagellin; Reviewed; Region: PRK08869 698758006121 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 698758006122 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 698758006123 carbon storage regulator; Provisional; Region: PRK01712 698758006124 flagellar assembly protein FliW; Provisional; Region: PRK13285 698758006125 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 698758006126 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 698758006127 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 698758006128 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 698758006129 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 698758006130 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 698758006131 FlgN protein; Region: FlgN; pfam05130 698758006132 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 698758006133 flagellar operon protein TIGR03826; Region: YvyF 698758006134 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 698758006135 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698758006136 active site 698758006137 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 698758006138 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698758006139 ATP binding site [chemical binding]; other site 698758006140 putative Mg++ binding site [ion binding]; other site 698758006141 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698758006142 nucleotide binding region [chemical binding]; other site 698758006143 ATP-binding site [chemical binding]; other site 698758006144 EDD domain protein, DegV family; Region: DegV; TIGR00762 698758006145 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698758006146 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698758006147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758006148 active site 698758006149 phosphorylation site [posttranslational modification] 698758006150 intermolecular recognition site; other site 698758006151 dimerization interface [polypeptide binding]; other site 698758006152 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698758006153 DNA binding residues [nucleotide binding] 698758006154 dimerization interface [polypeptide binding]; other site 698758006155 Sensor protein DegS; Region: DegS; pfam05384 698758006156 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 698758006157 Histidine kinase; Region: HisKA_3; pfam07730 698758006158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758006159 ATP binding site [chemical binding]; other site 698758006160 Mg2+ binding site [ion binding]; other site 698758006161 G-X-G motif; other site 698758006162 Predicted integral membrane protein [Function unknown]; Region: COG5578 698758006163 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698758006164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758006165 dimer interface [polypeptide binding]; other site 698758006166 conserved gate region; other site 698758006167 putative PBP binding loops; other site 698758006168 ABC-ATPase subunit interface; other site 698758006169 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 698758006170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758006171 dimer interface [polypeptide binding]; other site 698758006172 putative PBP binding loops; other site 698758006173 ABC-ATPase subunit interface; other site 698758006174 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698758006175 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698758006176 Response regulator receiver domain; Region: Response_reg; pfam00072 698758006177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758006178 active site 698758006179 phosphorylation site [posttranslational modification] 698758006180 intermolecular recognition site; other site 698758006181 dimerization interface [polypeptide binding]; other site 698758006182 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758006183 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698758006184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758006185 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 698758006186 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698758006187 dimerization interface [polypeptide binding]; other site 698758006188 Histidine kinase; Region: His_kinase; pfam06580 698758006189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758006190 ATP binding site [chemical binding]; other site 698758006191 Mg2+ binding site [ion binding]; other site 698758006192 G-X-G motif; other site 698758006193 Uncharacterized conserved protein [Function unknown]; Region: COG1739 698758006194 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 698758006195 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 698758006196 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 698758006197 active site 698758006198 catalytic site [active] 698758006199 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 698758006200 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 698758006201 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698758006202 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698758006203 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698758006204 Integrase core domain; Region: rve; pfam00665 698758006205 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 698758006206 Integrase core domain; Region: rve; pfam00665 698758006207 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698758006208 Integrase core domain; Region: rve_3; cl15866 698758006209 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698758006210 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 698758006211 active site 698758006212 NTP binding site [chemical binding]; other site 698758006213 metal binding triad [ion binding]; metal-binding site 698758006214 Domain of unknown function (DUF771); Region: DUF771; pfam05595 698758006215 potential frameshift: common BLAST hit: gi|375362546|ref|YP_005130585.1| Tyrosine recombinase xerC 698758006216 potential frameshift: common BLAST hit: gi|305674639|ref|YP_003866311.1| integrase (phage-related protein) 698758006217 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 698758006218 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 698758006219 Int/Topo IB signature motif; other site 698758006220 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 698758006221 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 698758006222 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 698758006223 SurA N-terminal domain; Region: SurA_N_3; cl07813 698758006224 Cold-inducible protein YdjO; Region: YdjO; pfam14169 698758006225 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698758006226 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698758006227 active site 698758006228 catalytic tetrad [active] 698758006229 glycerol kinase; Provisional; Region: glpK; PRK00047 698758006230 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 698758006231 N- and C-terminal domain interface [polypeptide binding]; other site 698758006232 active site 698758006233 MgATP binding site [chemical binding]; other site 698758006234 catalytic site [active] 698758006235 metal binding site [ion binding]; metal-binding site 698758006236 glycerol binding site [chemical binding]; other site 698758006237 homotetramer interface [polypeptide binding]; other site 698758006238 homodimer interface [polypeptide binding]; other site 698758006239 FBP binding site [chemical binding]; other site 698758006240 protein IIAGlc interface [polypeptide binding]; other site 698758006241 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 698758006242 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 698758006243 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 698758006244 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 698758006245 active site 698758006246 substrate binding site [chemical binding]; other site 698758006247 metal binding site [ion binding]; metal-binding site 698758006248 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 698758006249 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 698758006250 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 698758006251 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 698758006252 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698758006253 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698758006254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758006255 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 698758006256 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698758006257 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698758006258 active site 698758006259 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 698758006260 active site 698758006261 catalytic residues [active] 698758006262 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698758006263 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698758006264 synthetase active site [active] 698758006265 NTP binding site [chemical binding]; other site 698758006266 metal binding site [ion binding]; metal-binding site 698758006267 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 698758006268 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 698758006269 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 698758006270 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698758006271 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698758006272 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698758006273 metal binding site [ion binding]; metal-binding site 698758006274 active site 698758006275 I-site; other site 698758006276 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 698758006277 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698758006278 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 698758006279 Cache domain; Region: Cache_1; pfam02743 698758006280 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 698758006281 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698758006282 dimerization interface [polypeptide binding]; other site 698758006283 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698758006284 dimer interface [polypeptide binding]; other site 698758006285 putative CheW interface [polypeptide binding]; other site 698758006286 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698758006287 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698758006288 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698758006289 6-phosphofructokinase; Provisional; Region: PRK03202 698758006290 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 698758006291 active site 698758006292 ADP/pyrophosphate binding site [chemical binding]; other site 698758006293 dimerization interface [polypeptide binding]; other site 698758006294 allosteric effector site; other site 698758006295 fructose-1,6-bisphosphate binding site; other site 698758006296 hypothetical protein; Provisional; Region: PRK06851 698758006297 NTPase; Region: NTPase_1; cl17478 698758006298 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 698758006299 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698758006300 ligand binding site [chemical binding]; other site 698758006301 dimerization interface [polypeptide binding]; other site 698758006302 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698758006303 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698758006304 TM-ABC transporter signature motif; other site 698758006305 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698758006306 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698758006307 Walker A/P-loop; other site 698758006308 ATP binding site [chemical binding]; other site 698758006309 Q-loop/lid; other site 698758006310 ABC transporter signature motif; other site 698758006311 Walker B; other site 698758006312 D-loop; other site 698758006313 H-loop/switch region; other site 698758006314 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698758006315 D-ribose pyranase; Provisional; Region: PRK11797 698758006316 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698758006317 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 698758006318 substrate binding site [chemical binding]; other site 698758006319 dimer interface [polypeptide binding]; other site 698758006320 ATP binding site [chemical binding]; other site 698758006321 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698758006322 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698758006323 DNA binding site [nucleotide binding] 698758006324 domain linker motif; other site 698758006325 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 698758006326 dimerization interface [polypeptide binding]; other site 698758006327 ligand binding site [chemical binding]; other site 698758006328 sodium binding site [ion binding]; other site 698758006329 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 698758006330 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 698758006331 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 698758006332 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 698758006333 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 698758006334 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698758006335 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698758006336 Walker A/P-loop; other site 698758006337 ATP binding site [chemical binding]; other site 698758006338 Q-loop/lid; other site 698758006339 ABC transporter signature motif; other site 698758006340 Walker B; other site 698758006341 D-loop; other site 698758006342 H-loop/switch region; other site 698758006343 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698758006344 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698758006345 Walker A/P-loop; other site 698758006346 ATP binding site [chemical binding]; other site 698758006347 Q-loop/lid; other site 698758006348 ABC transporter signature motif; other site 698758006349 Walker B; other site 698758006350 D-loop; other site 698758006351 H-loop/switch region; other site 698758006352 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698758006353 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698758006354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758006355 dimer interface [polypeptide binding]; other site 698758006356 conserved gate region; other site 698758006357 putative PBP binding loops; other site 698758006358 ABC-ATPase subunit interface; other site 698758006359 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 698758006360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758006361 putative PBP binding loops; other site 698758006362 dimer interface [polypeptide binding]; other site 698758006363 ABC-ATPase subunit interface; other site 698758006364 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698758006365 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698758006366 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698758006367 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698758006368 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698758006369 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698758006370 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 698758006371 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 698758006372 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 698758006373 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698758006374 dimerization interface [polypeptide binding]; other site 698758006375 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698758006376 dimer interface [polypeptide binding]; other site 698758006377 putative CheW interface [polypeptide binding]; other site 698758006378 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698758006379 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698758006380 active site 698758006381 catalytic tetrad [active] 698758006382 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 698758006383 Double zinc ribbon; Region: DZR; pfam12773 698758006384 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 698758006385 ComK protein; Region: ComK; cl11560 698758006386 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698758006387 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698758006388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758006389 Walker A/P-loop; other site 698758006390 ATP binding site [chemical binding]; other site 698758006391 Q-loop/lid; other site 698758006392 ABC transporter signature motif; other site 698758006393 Walker B; other site 698758006394 D-loop; other site 698758006395 H-loop/switch region; other site 698758006396 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698758006397 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698758006398 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 698758006399 Walker A/P-loop; other site 698758006400 ATP binding site [chemical binding]; other site 698758006401 Q-loop/lid; other site 698758006402 ABC transporter signature motif; other site 698758006403 Walker B; other site 698758006404 D-loop; other site 698758006405 H-loop/switch region; other site 698758006406 Nuclease-related domain; Region: NERD; pfam08378 698758006407 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 698758006408 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698758006409 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698758006410 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 698758006411 Right handed beta helix region; Region: Beta_helix; pfam13229 698758006412 Cupin domain; Region: Cupin_2; pfam07883 698758006413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758006414 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698758006415 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758006416 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 698758006417 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 698758006418 Predicted permeases [General function prediction only]; Region: COG0679 698758006419 Uncharacterized conserved protein [Function unknown]; Region: COG3937 698758006420 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 698758006421 ligand binding site [chemical binding]; other site 698758006422 active site 698758006423 UGI interface [polypeptide binding]; other site 698758006424 catalytic site [active] 698758006425 amidase; Provisional; Region: PRK06529 698758006426 Amidase; Region: Amidase; cl11426 698758006427 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 698758006428 active site 1 [active] 698758006429 dimer interface [polypeptide binding]; other site 698758006430 hexamer interface [polypeptide binding]; other site 698758006431 active site 2 [active] 698758006432 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 698758006433 substrate binding site [chemical binding]; other site 698758006434 THF binding site; other site 698758006435 zinc-binding site [ion binding]; other site 698758006436 cystathionine gamma-synthase; Reviewed; Region: PRK08247 698758006437 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698758006438 homodimer interface [polypeptide binding]; other site 698758006439 substrate-cofactor binding pocket; other site 698758006440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698758006441 catalytic residue [active] 698758006442 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698758006443 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 698758006444 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 698758006445 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 698758006446 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698758006447 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698758006448 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 698758006449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 698758006450 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 698758006451 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 698758006452 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 698758006453 non-specific DNA binding site [nucleotide binding]; other site 698758006454 salt bridge; other site 698758006455 sequence-specific DNA binding site [nucleotide binding]; other site 698758006456 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 698758006457 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 698758006458 GIY-YIG motif/motif A; other site 698758006459 active site 698758006460 catalytic site [active] 698758006461 metal binding site [ion binding]; metal-binding site 698758006462 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698758006463 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 698758006464 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 698758006465 Predicted integral membrane protein [Function unknown]; Region: COG5652 698758006466 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 698758006467 substrate binding site [chemical binding]; other site 698758006468 THF binding site; other site 698758006469 zinc-binding site [ion binding]; other site 698758006470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698758006471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698758006472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698758006473 dimerization interface [polypeptide binding]; other site 698758006474 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698758006475 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 698758006476 putative NAD(P) binding site [chemical binding]; other site 698758006477 active site 698758006478 putative substrate binding site [chemical binding]; other site 698758006479 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 698758006480 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 698758006481 potential frameshift: common BLAST hit: gi|239814200|ref|YP_002943110.1| polysaccharide pyruvyl transferase 698758006482 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 698758006483 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 698758006484 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 698758006485 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 698758006486 putative ADP-binding pocket [chemical binding]; other site 698758006487 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698758006488 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698758006489 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698758006490 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698758006491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698758006492 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 698758006493 NAD(P) binding site [chemical binding]; other site 698758006494 active site 698758006495 Bacterial sugar transferase; Region: Bac_transf; pfam02397 698758006496 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 698758006497 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 698758006498 NAD(P) binding site [chemical binding]; other site 698758006499 homodimer interface [polypeptide binding]; other site 698758006500 substrate binding site [chemical binding]; other site 698758006501 active site 698758006502 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698758006503 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 698758006504 active site 698758006505 tetramer interface; other site 698758006506 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 698758006507 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 698758006508 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 698758006509 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698758006510 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 698758006511 Chain length determinant protein; Region: Wzz; cl15801 698758006512 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698758006513 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 698758006514 Double zinc ribbon; Region: DZR; pfam12773 698758006515 Nuclease-related domain; Region: NERD; pfam08378 698758006516 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698758006517 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 698758006518 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 698758006519 active site 698758006520 homodimer interface [polypeptide binding]; other site 698758006521 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 698758006522 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 698758006523 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 698758006524 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 698758006525 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 698758006526 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 698758006527 Walker A/P-loop; other site 698758006528 ATP binding site [chemical binding]; other site 698758006529 Q-loop/lid; other site 698758006530 ABC transporter signature motif; other site 698758006531 Walker B; other site 698758006532 D-loop; other site 698758006533 H-loop/switch region; other site 698758006534 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698758006535 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698758006536 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 698758006537 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 698758006538 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 698758006539 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 698758006540 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 698758006541 putative ADP-binding pocket [chemical binding]; other site 698758006542 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698758006543 Bacterial SH3 domain; Region: SH3_3; pfam08239 698758006544 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 698758006545 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 698758006546 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 698758006547 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 698758006548 active site 698758006549 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 698758006550 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 698758006551 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 698758006552 Mg++ binding site [ion binding]; other site 698758006553 putative catalytic motif [active] 698758006554 substrate binding site [chemical binding]; other site 698758006555 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101 698758006556 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 698758006557 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698758006558 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 698758006559 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 698758006560 MviN-like protein; Region: MVIN; pfam03023 698758006561 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 698758006562 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 698758006563 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 698758006564 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 698758006565 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 698758006566 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 698758006567 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 698758006568 rod shape-determining protein Mbl; Provisional; Region: PRK13928 698758006569 MreB and similar proteins; Region: MreB_like; cd10225 698758006570 nucleotide binding site [chemical binding]; other site 698758006571 Mg binding site [ion binding]; other site 698758006572 putative protofilament interaction site [polypeptide binding]; other site 698758006573 RodZ interaction site [polypeptide binding]; other site 698758006574 Stage III sporulation protein D; Region: SpoIIID; pfam12116 698758006575 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698758006576 Peptidase family M23; Region: Peptidase_M23; pfam01551 698758006577 stage II sporulation protein D; Region: spore_II_D; TIGR02870 698758006578 Stage II sporulation protein; Region: SpoIID; pfam08486 698758006579 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698758006580 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698758006581 hinge; other site 698758006582 active site 698758006583 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 698758006584 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 698758006585 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 698758006586 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 698758006587 putative active site [active] 698758006588 catalytic triad [active] 698758006589 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 698758006590 putative integrin binding motif; other site 698758006591 PA/protease domain interface [polypeptide binding]; other site 698758006592 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 698758006593 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698758006594 active site 698758006595 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 698758006596 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 698758006597 dimer interface [polypeptide binding]; other site 698758006598 active site 698758006599 glycine-pyridoxal phosphate binding site [chemical binding]; other site 698758006600 folate binding site [chemical binding]; other site 698758006601 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 698758006602 Low molecular weight phosphatase family; Region: LMWPc; cl00105 698758006603 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 698758006604 Predicted membrane protein [Function unknown]; Region: COG1971 698758006605 Domain of unknown function DUF; Region: DUF204; pfam02659 698758006606 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 698758006607 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 698758006608 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 698758006609 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 698758006610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758006611 S-adenosylmethionine binding site [chemical binding]; other site 698758006612 peptide chain release factor 1; Validated; Region: prfA; PRK00591 698758006613 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698758006614 RF-1 domain; Region: RF-1; pfam00472 698758006615 thymidine kinase; Provisional; Region: PRK04296 698758006616 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 698758006617 Nuclease-related domain; Region: NERD; pfam08378 698758006618 transcription termination factor Rho; Provisional; Region: rho; PRK09376 698758006619 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 698758006620 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 698758006621 RNA binding site [nucleotide binding]; other site 698758006622 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 698758006623 multimer interface [polypeptide binding]; other site 698758006624 Walker A motif; other site 698758006625 ATP binding site [chemical binding]; other site 698758006626 Walker B motif; other site 698758006627 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698758006628 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698758006629 hinge; other site 698758006630 active site 698758006631 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 698758006632 intersubunit interface [polypeptide binding]; other site 698758006633 active site 698758006634 zinc binding site [ion binding]; other site 698758006635 Na+ binding site [ion binding]; other site 698758006636 Response regulator receiver domain; Region: Response_reg; pfam00072 698758006637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758006638 active site 698758006639 phosphorylation site [posttranslational modification] 698758006640 intermolecular recognition site; other site 698758006641 dimerization interface [polypeptide binding]; other site 698758006642 CTP synthetase; Validated; Region: pyrG; PRK05380 698758006643 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 698758006644 Catalytic site [active] 698758006645 active site 698758006646 UTP binding site [chemical binding]; other site 698758006647 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 698758006648 active site 698758006649 putative oxyanion hole; other site 698758006650 catalytic triad [active] 698758006651 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 698758006652 AAA domain; Region: AAA_33; pfam13671 698758006653 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 698758006654 active site 698758006655 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 698758006656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698758006657 putative substrate translocation pore; other site 698758006658 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 698758006659 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 698758006660 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 698758006661 active site 698758006662 HIGH motif; other site 698758006663 KMSK motif region; other site 698758006664 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 698758006665 tRNA binding surface [nucleotide binding]; other site 698758006666 anticodon binding site; other site 698758006667 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 698758006668 Transglycosylase; Region: Transgly; pfam00912 698758006669 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 698758006670 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698758006671 Uncharacterized conserved protein [Function unknown]; Region: COG3465 698758006672 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 698758006673 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698758006674 Zn2+ binding site [ion binding]; other site 698758006675 Mg2+ binding site [ion binding]; other site 698758006676 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 698758006677 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 698758006678 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 698758006679 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 698758006680 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 698758006681 HTH-like domain; Region: HTH_21; pfam13276 698758006682 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698758006683 Integrase core domain; Region: rve; pfam00665 698758006684 Integrase core domain; Region: rve_2; pfam13333 698758006685 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698758006686 Helix-turn-helix domain; Region: HTH_28; pfam13518 698758006687 Helix-turn-helix domain; Region: HTH_28; pfam13518 698758006688 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698758006689 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698758006690 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 698758006691 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698758006692 ATP binding site [chemical binding]; other site 698758006693 putative Mg++ binding site [ion binding]; other site 698758006694 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698758006695 nucleotide binding region [chemical binding]; other site 698758006696 ATP-binding site [chemical binding]; other site 698758006697 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 698758006698 HRDC domain; Region: HRDC; pfam00570 698758006699 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 698758006700 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 698758006701 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 698758006702 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 698758006703 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698758006704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758006705 Walker A/P-loop; other site 698758006706 ATP binding site [chemical binding]; other site 698758006707 Q-loop/lid; other site 698758006708 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698758006709 ABC transporter signature motif; other site 698758006710 Walker B; other site 698758006711 D-loop; other site 698758006712 ABC transporter; Region: ABC_tran_2; pfam12848 698758006713 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698758006714 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 698758006715 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 698758006716 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 698758006717 putative active site [active] 698758006718 catalytic site [active] 698758006719 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 698758006720 putative active site [active] 698758006721 catalytic site [active] 698758006722 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 698758006723 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 698758006724 putative dimer interface [polypeptide binding]; other site 698758006725 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 698758006726 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698758006727 homodimer interface [polypeptide binding]; other site 698758006728 substrate-cofactor binding pocket; other site 698758006729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698758006730 catalytic residue [active] 698758006731 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 698758006732 active site 698758006733 catalytic triad [active] 698758006734 oxyanion hole [active] 698758006735 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 698758006736 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 698758006737 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 698758006738 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698758006739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758006740 active site 698758006741 phosphorylation site [posttranslational modification] 698758006742 intermolecular recognition site; other site 698758006743 dimerization interface [polypeptide binding]; other site 698758006744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698758006745 DNA binding residues [nucleotide binding] 698758006746 dimerization interface [polypeptide binding]; other site 698758006747 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 698758006748 Histidine kinase; Region: HisKA_3; pfam07730 698758006749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758006750 ATP binding site [chemical binding]; other site 698758006751 Mg2+ binding site [ion binding]; other site 698758006752 G-X-G motif; other site 698758006753 Predicted membrane protein [Function unknown]; Region: COG4758 698758006754 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 698758006755 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 698758006756 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 698758006757 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 698758006758 DNA topoisomerase III; Provisional; Region: PRK07726 698758006759 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 698758006760 active site 698758006761 putative interdomain interaction site [polypeptide binding]; other site 698758006762 putative metal-binding site [ion binding]; other site 698758006763 putative nucleotide binding site [chemical binding]; other site 698758006764 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698758006765 domain I; other site 698758006766 DNA binding groove [nucleotide binding] 698758006767 phosphate binding site [ion binding]; other site 698758006768 domain II; other site 698758006769 domain III; other site 698758006770 nucleotide binding site [chemical binding]; other site 698758006771 catalytic site [active] 698758006772 domain IV; other site 698758006773 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 698758006774 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 698758006775 dimer interface [polypeptide binding]; other site 698758006776 FMN binding site [chemical binding]; other site 698758006777 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 698758006778 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698758006779 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698758006780 ABC transporter; Region: ABC_tran_2; pfam12848 698758006781 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698758006782 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 698758006783 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698758006784 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698758006785 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698758006786 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698758006787 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698758006788 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698758006789 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 698758006790 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 698758006791 substrate binding site [chemical binding]; other site 698758006792 active site 698758006793 catalytic residues [active] 698758006794 heterodimer interface [polypeptide binding]; other site 698758006795 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698758006796 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698758006797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698758006798 catalytic residue [active] 698758006799 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 698758006800 active site 698758006801 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698758006802 active site 698758006803 ribulose/triose binding site [chemical binding]; other site 698758006804 phosphate binding site [ion binding]; other site 698758006805 substrate (anthranilate) binding pocket [chemical binding]; other site 698758006806 product (indole) binding pocket [chemical binding]; other site 698758006807 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 698758006808 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698758006809 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698758006810 anthranilate synthase component I; Provisional; Region: PRK13570 698758006811 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 698758006812 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698758006813 3-dehydroquinate synthase (EC 4.6.1.3); Region: DHQS; cl00640 698758006814 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698758006815 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698758006816 3D domain; Region: 3D; cl01439 698758006817 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 698758006818 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 698758006819 active site 698758006820 catalytic residues [active] 698758006821 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 698758006822 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 698758006823 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 698758006824 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698758006825 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698758006826 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698758006827 dimer interface [polypeptide binding]; other site 698758006828 putative CheW interface [polypeptide binding]; other site 698758006829 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698758006830 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698758006831 DNA binding site [nucleotide binding] 698758006832 domain linker motif; other site 698758006833 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 698758006834 dimerization interface [polypeptide binding]; other site 698758006835 ligand binding site [chemical binding]; other site 698758006836 Protein of unknown function, DUF624; Region: DUF624; cl02369 698758006837 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698758006838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758006839 dimer interface [polypeptide binding]; other site 698758006840 conserved gate region; other site 698758006841 putative PBP binding loops; other site 698758006842 ABC-ATPase subunit interface; other site 698758006843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758006844 dimer interface [polypeptide binding]; other site 698758006845 conserved gate region; other site 698758006846 putative PBP binding loops; other site 698758006847 ABC-ATPase subunit interface; other site 698758006848 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698758006849 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698758006850 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698758006851 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698758006852 nucleotide binding site [chemical binding]; other site 698758006853 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 698758006854 beta-galactosidase; Region: BGL; TIGR03356 698758006855 galactokinase; Provisional; Region: PRK05322 698758006856 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698758006857 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698758006858 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698758006859 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698758006860 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698758006861 NAD binding site [chemical binding]; other site 698758006862 homodimer interface [polypeptide binding]; other site 698758006863 active site 698758006864 substrate binding site [chemical binding]; other site 698758006865 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 698758006866 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 698758006867 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 698758006868 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 698758006869 active site 698758006870 catalytic residues [active] 698758006871 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 698758006872 AAA domain; Region: AAA_18; pfam13238 698758006873 active site 698758006874 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698758006875 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698758006876 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698758006877 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 698758006878 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698758006879 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698758006880 nucleotide binding site [chemical binding]; other site 698758006881 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698758006882 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 698758006883 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 698758006884 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 698758006885 putative active site [active] 698758006886 putative catalytic site [active] 698758006887 Cupin domain; Region: Cupin_2; pfam07883 698758006888 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758006889 Helix-turn-helix domain; Region: HTH_18; pfam12833 698758006890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758006891 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 698758006892 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698758006893 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 698758006894 active site 698758006895 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 698758006896 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 698758006897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758006898 active site 698758006899 motif I; other site 698758006900 motif II; other site 698758006901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758006902 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 698758006903 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 698758006904 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698758006905 Zn binding site [ion binding]; other site 698758006906 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 698758006907 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698758006908 Zn binding site [ion binding]; other site 698758006909 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 698758006910 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 698758006911 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698758006912 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698758006913 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 698758006914 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 698758006915 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 698758006916 active site 698758006917 dimer interface [polypeptide binding]; other site 698758006918 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698758006919 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 698758006920 active site 698758006921 trimer interface [polypeptide binding]; other site 698758006922 allosteric site; other site 698758006923 active site lid [active] 698758006924 hexamer (dimer of trimers) interface [polypeptide binding]; other site 698758006925 zinc transporter ZupT; Provisional; Region: PRK04201 698758006926 ZIP Zinc transporter; Region: Zip; pfam02535 698758006927 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 698758006928 Part of AAA domain; Region: AAA_19; pfam13245 698758006929 Family description; Region: UvrD_C_2; pfam13538 698758006930 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 698758006931 homotrimer interaction site [polypeptide binding]; other site 698758006932 putative active site [active] 698758006933 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 698758006934 NAD-dependent deacetylase; Provisional; Region: PRK00481 698758006935 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 698758006936 NAD+ binding site [chemical binding]; other site 698758006937 substrate binding site [chemical binding]; other site 698758006938 Zn binding site [ion binding]; other site 698758006939 alpha-galactosidase; Region: PLN02808; cl17638 698758006940 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 698758006941 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 698758006942 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698758006943 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698758006944 DNA-binding site [nucleotide binding]; DNA binding site 698758006945 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 698758006946 putative dimerization interface [polypeptide binding]; other site 698758006947 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 698758006948 putative ligand binding site [chemical binding]; other site 698758006949 L-arabinose isomerase; Provisional; Region: PRK02929 698758006950 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 698758006951 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 698758006952 trimer interface [polypeptide binding]; other site 698758006953 putative substrate binding site [chemical binding]; other site 698758006954 putative metal binding site [ion binding]; other site 698758006955 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 698758006956 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 698758006957 intersubunit interface [polypeptide binding]; other site 698758006958 active site 698758006959 Zn2+ binding site [ion binding]; other site 698758006960 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698758006961 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 698758006962 NAD(P) binding site [chemical binding]; other site 698758006963 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698758006964 EamA-like transporter family; Region: EamA; pfam00892 698758006965 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698758006966 dimerization interface [polypeptide binding]; other site 698758006967 putative DNA binding site [nucleotide binding]; other site 698758006968 putative Zn2+ binding site [ion binding]; other site 698758006969 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 698758006970 putative metal binding site [ion binding]; other site 698758006971 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 698758006972 Interdomain contacts; other site 698758006973 Cytokine receptor motif; other site 698758006974 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 698758006975 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698758006976 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698758006977 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698758006978 acetylornithine aminotransferase; Provisional; Region: PRK02627 698758006979 inhibitor-cofactor binding pocket; inhibition site 698758006980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698758006981 catalytic residue [active] 698758006982 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 698758006983 nucleotide binding site [chemical binding]; other site 698758006984 N-acetyl-L-glutamate binding site [chemical binding]; other site 698758006985 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 698758006986 heterotetramer interface [polypeptide binding]; other site 698758006987 active site pocket [active] 698758006988 cleavage site 698758006989 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 698758006990 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698758006991 OsmC-like protein; Region: OsmC; pfam02566 698758006992 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 698758006993 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698758006994 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698758006995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698758006996 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698758006997 putative substrate translocation pore; other site 698758006998 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698758006999 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698758007000 DNA binding residues [nucleotide binding] 698758007001 dimerization interface [polypeptide binding]; other site 698758007002 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 698758007003 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 698758007004 Potassium binding sites [ion binding]; other site 698758007005 Cesium cation binding sites [ion binding]; other site 698758007006 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698758007007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758007008 S-adenosylmethionine binding site [chemical binding]; other site 698758007009 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 698758007010 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 698758007011 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 698758007012 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 698758007013 YpjP-like protein; Region: YpjP; pfam14005 698758007014 CAAX protease self-immunity; Region: Abi; pfam02517 698758007015 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 698758007016 EDD domain protein, DegV family; Region: DegV; TIGR00762 698758007017 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698758007018 YtoQ family protein; Region: YtoQ_fam; TIGR03646 698758007019 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 698758007020 homodimer interface [polypeptide binding]; other site 698758007021 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698758007022 substrate-cofactor binding pocket; other site 698758007023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698758007024 catalytic residue [active] 698758007025 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 698758007026 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698758007027 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698758007028 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 698758007029 active site 698758007030 P-loop; other site 698758007031 phosphorylation site [posttranslational modification] 698758007032 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 698758007033 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 698758007034 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 698758007035 methionine cluster; other site 698758007036 active site 698758007037 phosphorylation site [posttranslational modification] 698758007038 metal binding site [ion binding]; metal-binding site 698758007039 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 698758007040 beta-galactosidase; Region: BGL; TIGR03356 698758007041 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 698758007042 HTH domain; Region: HTH_11; pfam08279 698758007043 Mga helix-turn-helix domain; Region: Mga; pfam05043 698758007044 PRD domain; Region: PRD; pfam00874 698758007045 PRD domain; Region: PRD; pfam00874 698758007046 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 698758007047 active site 698758007048 P-loop; other site 698758007049 phosphorylation site [posttranslational modification] 698758007050 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698758007051 active site 698758007052 phosphorylation site [posttranslational modification] 698758007053 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 698758007054 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 698758007055 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698758007056 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 698758007057 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698758007058 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698758007059 Walker A/P-loop; other site 698758007060 ATP binding site [chemical binding]; other site 698758007061 Q-loop/lid; other site 698758007062 ABC transporter signature motif; other site 698758007063 Walker B; other site 698758007064 D-loop; other site 698758007065 H-loop/switch region; other site 698758007066 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698758007067 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 698758007068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698758007069 DNA-binding site [nucleotide binding]; DNA binding site 698758007070 UTRA domain; Region: UTRA; pfam07702 698758007071 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 698758007072 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 698758007073 Ca binding site [ion binding]; other site 698758007074 active site 698758007075 catalytic site [active] 698758007076 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 698758007077 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 698758007078 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698758007079 active site turn [active] 698758007080 phosphorylation site [posttranslational modification] 698758007081 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698758007082 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698758007083 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698758007084 ligand binding site [chemical binding]; other site 698758007085 flexible hinge region; other site 698758007086 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698758007087 putative switch regulator; other site 698758007088 non-specific DNA interactions [nucleotide binding]; other site 698758007089 DNA binding site [nucleotide binding] 698758007090 sequence specific DNA binding site [nucleotide binding]; other site 698758007091 putative cAMP binding site [chemical binding]; other site 698758007092 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698758007093 metal-binding site [ion binding] 698758007094 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698758007095 Peptidase family M23; Region: Peptidase_M23; pfam01551 698758007096 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 698758007097 Predicted secreted protein [Function unknown]; Region: COG4086 698758007098 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 698758007099 maltose O-acetyltransferase; Provisional; Region: PRK10092 698758007100 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 698758007101 active site 698758007102 substrate binding site [chemical binding]; other site 698758007103 trimer interface [polypeptide binding]; other site 698758007104 CoA binding site [chemical binding]; other site 698758007105 peroxiredoxin; Region: AhpC; TIGR03137 698758007106 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 698758007107 dimer interface [polypeptide binding]; other site 698758007108 decamer (pentamer of dimers) interface [polypeptide binding]; other site 698758007109 catalytic triad [active] 698758007110 peroxidatic and resolving cysteines [active] 698758007111 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 698758007112 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 698758007113 catalytic residue [active] 698758007114 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 698758007115 catalytic residues [active] 698758007116 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698758007117 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698758007118 short chain dehydrogenase; Provisional; Region: PRK06701 698758007119 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 698758007120 NAD binding site [chemical binding]; other site 698758007121 metal binding site [ion binding]; metal-binding site 698758007122 active site 698758007123 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 698758007124 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 698758007125 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 698758007126 hexamer interface [polypeptide binding]; other site 698758007127 ligand binding site [chemical binding]; other site 698758007128 putative active site [active] 698758007129 NAD(P) binding site [chemical binding]; other site 698758007130 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 698758007131 quinolinate synthetase; Provisional; Region: PRK09375 698758007132 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 698758007133 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 698758007134 dimerization interface [polypeptide binding]; other site 698758007135 active site 698758007136 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 698758007137 Carbohydrate Binding Module families 36 (CBM36) and 6 (CBM6); appended mainly to glycoside hydrolase family 11 (GH11) domains; xylan binding; Region: CBM6_36_xylanase-like; cd04078 698758007138 Ca binding site [ion binding]; other site 698758007139 Ca binding site (active) [ion binding]; other site 698758007140 ligand binding site [chemical binding]; other site 698758007141 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698758007142 Domain of unknown function DUF21; Region: DUF21; pfam01595 698758007143 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698758007144 Transporter associated domain; Region: CorC_HlyC; pfam03471 698758007145 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698758007146 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 698758007147 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 698758007148 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 698758007149 E-class dimer interface [polypeptide binding]; other site 698758007150 P-class dimer interface [polypeptide binding]; other site 698758007151 active site 698758007152 Cu2+ binding site [ion binding]; other site 698758007153 Zn2+ binding site [ion binding]; other site 698758007154 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698758007155 dimerization interface [polypeptide binding]; other site 698758007156 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698758007157 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698758007158 dimer interface [polypeptide binding]; other site 698758007159 putative CheW interface [polypeptide binding]; other site 698758007160 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698758007161 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698758007162 active site 698758007163 catalytic tetrad [active] 698758007164 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698758007165 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698758007166 Ubiquitin-like proteins; Region: UBQ; cl00155 698758007167 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 698758007168 Domain of unknown function (DUF378); Region: DUF378; pfam04070 698758007169 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698758007170 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 698758007171 putative active site [active] 698758007172 putative FMN binding site [chemical binding]; other site 698758007173 putative substrate binding site [chemical binding]; other site 698758007174 putative catalytic residue [active] 698758007175 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 698758007176 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 698758007177 classical (c) SDRs; Region: SDR_c; cd05233 698758007178 NAD(P) binding site [chemical binding]; other site 698758007179 active site 698758007180 QueT transporter; Region: QueT; pfam06177 698758007181 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698758007182 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698758007183 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698758007184 HRDC domain; Region: HRDC; pfam00570 698758007185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758007186 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698758007187 active site 698758007188 motif I; other site 698758007189 motif II; other site 698758007190 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698758007191 Predicted GTPase [General function prediction only]; Region: COG2403 698758007192 Integrase core domain; Region: rve; pfam00665 698758007193 Integrase core domain; Region: rve_2; pfam13333 698758007194 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 698758007195 Integrase core domain; Region: rve; pfam00665 698758007196 DDE domain; Region: DDE_Tnp_IS240; pfam13610 698758007197 Integrase core domain; Region: rve_3; cl15866 698758007198 Probable transposase; Region: OrfB_IS605; pfam01385 698758007199 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 698758007200 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 698758007201 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 698758007202 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698758007203 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698758007204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758007205 Walker A/P-loop; other site 698758007206 ATP binding site [chemical binding]; other site 698758007207 Q-loop/lid; other site 698758007208 ABC transporter signature motif; other site 698758007209 Walker B; other site 698758007210 D-loop; other site 698758007211 H-loop/switch region; other site 698758007212 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 698758007213 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698758007214 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698758007215 active site 698758007216 catalytic tetrad [active] 698758007217 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 698758007218 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 698758007219 Domain of unknown function (DUF377); Region: DUF377; pfam04041 698758007220 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 698758007221 active site 698758007222 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698758007223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758007224 dimer interface [polypeptide binding]; other site 698758007225 conserved gate region; other site 698758007226 putative PBP binding loops; other site 698758007227 ABC-ATPase subunit interface; other site 698758007228 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 698758007229 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698758007230 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698758007231 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 698758007232 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698758007233 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 698758007234 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698758007235 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698758007236 DNA binding site [nucleotide binding] 698758007237 domain linker motif; other site 698758007238 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 698758007239 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 698758007240 active site 698758007241 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 698758007242 putative active cleft [active] 698758007243 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 698758007244 active site 698758007245 P-loop; other site 698758007246 phosphorylation site [posttranslational modification] 698758007247 potential frameshift: common BLAST hit: gi|56962260|ref|YP_173984.1| PTS system, cellobiose-specific enzyme II, C component 698758007248 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 698758007249 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 698758007250 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 698758007251 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 698758007252 methionine cluster; other site 698758007253 active site 698758007254 phosphorylation site [posttranslational modification] 698758007255 metal binding site [ion binding]; metal-binding site 698758007256 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 698758007257 beta-galactosidase; Region: BGL; TIGR03356 698758007258 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 698758007259 HTH domain; Region: HTH_11; pfam08279 698758007260 Mga helix-turn-helix domain; Region: Mga; pfam05043 698758007261 PRD domain; Region: PRD; pfam00874 698758007262 PRD domain; Region: PRD; pfam00874 698758007263 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 698758007264 active site 698758007265 P-loop; other site 698758007266 phosphorylation site [posttranslational modification] 698758007267 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698758007268 active site 698758007269 phosphorylation site [posttranslational modification] 698758007270 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 698758007271 Carbohydrate binding module 27; Region: CBM27; pfam09212 698758007272 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 698758007273 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 698758007274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 698758007275 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698758007276 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 698758007277 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698758007278 Helix-turn-helix domain; Region: HTH_28; pfam13518 698758007279 Helix-turn-helix domain; Region: HTH_28; pfam13518 698758007280 HTH-like domain; Region: HTH_21; pfam13276 698758007281 Integrase core domain; Region: rve_2; pfam13333 698758007282 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 698758007283 beta-galactosidase; Region: BGL; TIGR03356 698758007284 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698758007285 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698758007286 dimer interface [polypeptide binding]; other site 698758007287 putative CheW interface [polypeptide binding]; other site 698758007288 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698758007289 dimerization interface [polypeptide binding]; other site 698758007290 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698758007291 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698758007292 active site 698758007293 catalytic tetrad [active] 698758007294 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698758007295 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698758007296 nucleotide binding site [chemical binding]; other site 698758007297 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698758007298 Predicted GTPase [General function prediction only]; Region: COG2403 698758007299 Integrase core domain; Region: rve; pfam00665 698758007300 Integrase core domain; Region: rve_2; pfam13333 698758007301 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 698758007302 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 698758007303 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 698758007304 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698758007305 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 698758007306 NodB motif; other site 698758007307 active site 698758007308 catalytic site [active] 698758007309 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698758007310 Methyltransferase domain; Region: Methyltransf_32; pfam13679 698758007311 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 698758007312 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698758007313 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698758007314 active site 698758007315 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 698758007316 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 698758007317 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 698758007318 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 698758007319 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 698758007320 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 698758007321 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698758007322 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 698758007323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758007324 active site 698758007325 phosphorylation site [posttranslational modification] 698758007326 intermolecular recognition site; other site 698758007327 dimerization interface [polypeptide binding]; other site 698758007328 LytTr DNA-binding domain; Region: LytTR; smart00850 698758007329 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698758007330 dimerization interface [polypeptide binding]; other site 698758007331 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698758007332 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698758007333 dimer interface [polypeptide binding]; other site 698758007334 putative CheW interface [polypeptide binding]; other site 698758007335 putative glycosyl transferase; Provisional; Region: PRK10073 698758007336 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698758007337 active site 698758007338 potential frameshift: common BLAST hit: gi|326790385|ref|YP_004308206.1| xylan 1,4-beta-xylosidase 698758007339 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 698758007340 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 698758007341 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 698758007342 active site 698758007343 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 698758007344 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698758007345 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 698758007346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758007347 Walker B; other site 698758007348 D-loop; other site 698758007349 H-loop/switch region; other site 698758007350 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 698758007351 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 698758007352 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 698758007353 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 698758007354 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698758007355 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 698758007356 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 698758007357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758007358 active site 698758007359 phosphorylation site [posttranslational modification] 698758007360 intermolecular recognition site; other site 698758007361 dimerization interface [polypeptide binding]; other site 698758007362 LytTr DNA-binding domain; Region: LytTR; smart00850 698758007363 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 698758007364 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698758007365 UDP-galactopyranose mutase; Region: GLF; pfam03275 698758007366 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698758007367 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 698758007368 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698758007369 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698758007370 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698758007371 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 698758007372 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698758007373 metal binding site [ion binding]; metal-binding site 698758007374 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698758007375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758007376 dimer interface [polypeptide binding]; other site 698758007377 conserved gate region; other site 698758007378 ABC-ATPase subunit interface; other site 698758007379 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 698758007380 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698758007381 Walker A/P-loop; other site 698758007382 ATP binding site [chemical binding]; other site 698758007383 Q-loop/lid; other site 698758007384 ABC transporter signature motif; other site 698758007385 Walker B; other site 698758007386 D-loop; other site 698758007387 H-loop/switch region; other site 698758007388 NIL domain; Region: NIL; pfam09383 698758007389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698758007390 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698758007391 putative substrate translocation pore; other site 698758007392 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 698758007393 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698758007394 catalytic core [active] 698758007395 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698758007396 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 698758007397 NodB motif; other site 698758007398 active site 698758007399 catalytic site [active] 698758007400 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698758007401 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698758007402 active site 698758007403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758007404 S-adenosylmethionine binding site [chemical binding]; other site 698758007405 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698758007406 nucleoside/Zn binding site; other site 698758007407 dimer interface [polypeptide binding]; other site 698758007408 catalytic motif [active] 698758007409 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 698758007410 Part of AAA domain; Region: AAA_19; pfam13245 698758007411 Family description; Region: UvrD_C_2; pfam13538 698758007412 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 698758007413 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698758007414 Catalytic site [active] 698758007415 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 698758007416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 698758007417 YheO-like PAS domain; Region: PAS_6; pfam08348 698758007418 HTH domain; Region: HTH_22; pfam13309 698758007419 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 698758007420 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 698758007421 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 698758007422 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698758007423 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698758007424 metal binding site [ion binding]; metal-binding site 698758007425 active site 698758007426 I-site; other site 698758007427 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698758007428 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 698758007429 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698758007430 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 698758007431 putative active site [active] 698758007432 putative FMN binding site [chemical binding]; other site 698758007433 putative substrate binding site [chemical binding]; other site 698758007434 putative catalytic residue [active] 698758007435 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698758007436 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698758007437 DNA-binding site [nucleotide binding]; DNA binding site 698758007438 FCD domain; Region: FCD; pfam07729 698758007439 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 698758007440 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698758007441 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 698758007442 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 698758007443 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 698758007444 ATP cone domain; Region: ATP-cone; pfam03477 698758007445 Class III ribonucleotide reductase; Region: RNR_III; cd01675 698758007446 effector binding site; other site 698758007447 active site 698758007448 Zn binding site [ion binding]; other site 698758007449 glycine loop; other site 698758007450 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 698758007451 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 698758007452 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 698758007453 Staygreen protein; Region: Staygreen; pfam12638 698758007454 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698758007455 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698758007456 ATP binding site [chemical binding]; other site 698758007457 Mg++ binding site [ion binding]; other site 698758007458 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698758007459 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 698758007460 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698758007461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758007462 dimer interface [polypeptide binding]; other site 698758007463 conserved gate region; other site 698758007464 putative PBP binding loops; other site 698758007465 ABC-ATPase subunit interface; other site 698758007466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698758007467 dimer interface [polypeptide binding]; other site 698758007468 conserved gate region; other site 698758007469 putative PBP binding loops; other site 698758007470 ABC-ATPase subunit interface; other site 698758007471 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698758007472 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 698758007473 Walker A/P-loop; other site 698758007474 ATP binding site [chemical binding]; other site 698758007475 Q-loop/lid; other site 698758007476 ABC transporter signature motif; other site 698758007477 Walker B; other site 698758007478 D-loop; other site 698758007479 H-loop/switch region; other site 698758007480 TOBE domain; Region: TOBE_2; pfam08402 698758007481 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 698758007482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698758007483 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698758007484 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698758007485 active site residue [active] 698758007486 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698758007487 active site residue [active] 698758007488 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698758007489 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698758007490 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 698758007491 Walker A/P-loop; other site 698758007492 ATP binding site [chemical binding]; other site 698758007493 Q-loop/lid; other site 698758007494 ABC transporter signature motif; other site 698758007495 Walker B; other site 698758007496 D-loop; other site 698758007497 H-loop/switch region; other site 698758007498 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698758007499 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698758007500 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758007501 Walker A/P-loop; other site 698758007502 ATP binding site [chemical binding]; other site 698758007503 Q-loop/lid; other site 698758007504 ABC transporter signature motif; other site 698758007505 Walker B; other site 698758007506 D-loop; other site 698758007507 H-loop/switch region; other site 698758007508 putative S-transferase; Provisional; Region: PRK11752 698758007509 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 698758007510 C-terminal domain interface [polypeptide binding]; other site 698758007511 GSH binding site (G-site) [chemical binding]; other site 698758007512 dimer interface [polypeptide binding]; other site 698758007513 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 698758007514 dimer interface [polypeptide binding]; other site 698758007515 N-terminal domain interface [polypeptide binding]; other site 698758007516 active site 698758007517 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 698758007518 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 698758007519 active site 698758007520 homodimer interface [polypeptide binding]; other site 698758007521 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 698758007522 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 698758007523 DXD motif; other site 698758007524 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 698758007525 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 698758007526 NodB motif; other site 698758007527 putative active site [active] 698758007528 putative catalytic site [active] 698758007529 putative Zn binding site [ion binding]; other site 698758007530 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 698758007531 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 698758007532 Sulfate transporter family; Region: Sulfate_transp; pfam00916 698758007533 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 698758007534 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698758007535 dimer interface [polypeptide binding]; other site 698758007536 putative CheW interface [polypeptide binding]; other site 698758007537 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698758007538 metal binding site [ion binding]; metal-binding site 698758007539 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698758007540 metal binding site [ion binding]; metal-binding site 698758007541 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 698758007542 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 698758007543 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 698758007544 catalytic residue [active] 698758007545 putative FPP diphosphate binding site; other site 698758007546 putative FPP binding hydrophobic cleft; other site 698758007547 dimer interface [polypeptide binding]; other site 698758007548 putative IPP diphosphate binding site; other site 698758007549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698758007550 salt bridge; other site 698758007551 non-specific DNA binding site [nucleotide binding]; other site 698758007552 sequence-specific DNA binding site [nucleotide binding]; other site 698758007553 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 698758007554 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698758007555 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 698758007556 dimer interface [polypeptide binding]; other site 698758007557 active site 698758007558 metal binding site [ion binding]; metal-binding site 698758007559 glutathione binding site [chemical binding]; other site 698758007560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698758007561 Walker A/P-loop; other site 698758007562 ATP binding site [chemical binding]; other site 698758007563 Q-loop/lid; other site 698758007564 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 698758007565 active site 698758007566 metal binding site [ion binding]; metal-binding site 698758007567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698758007568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 698758007569 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 698758007570 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 698758007571 Virulence protein [General function prediction only]; Region: COG3943 698758007572 hypothetical protein; Validated; Region: PRK09169 698758007573 AAA domain; Region: AAA_22; pfam13401 698758007574 AAA domain; Region: AAA_30; pfam13604 698758007575 Family description; Region: UvrD_C_2; pfam13538 698758007576 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698758007577 active site 698758007578 ATP binding site [chemical binding]; other site 698758007579 substrate binding site [chemical binding]; other site 698758007580 activation loop (A-loop); other site 698758007581 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 698758007582 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698758007583 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 698758007584 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 698758007585 FAD binding pocket [chemical binding]; other site 698758007586 conserved FAD binding motif [chemical binding]; other site 698758007587 phosphate binding motif [ion binding]; other site 698758007588 beta-alpha-beta structure motif; other site 698758007589 NAD binding pocket [chemical binding]; other site 698758007590 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 698758007591 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698758007592 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698758007593 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698758007594 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698758007595 Domain of unknown function DUF21; Region: DUF21; pfam01595 698758007596 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698758007597 Transporter associated domain; Region: CorC_HlyC; pfam03471 698758007598 Uncharacterized conserved protein [Function unknown]; Region: COG1912 698758007599 hypothetical protein; Provisional; Region: PRK13661 698758007600 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698758007601 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698758007602 Walker A/P-loop; other site 698758007603 ATP binding site [chemical binding]; other site 698758007604 Q-loop/lid; other site 698758007605 ABC transporter signature motif; other site 698758007606 Walker B; other site 698758007607 D-loop; other site 698758007608 H-loop/switch region; other site 698758007609 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 698758007610 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698758007611 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698758007612 Walker A/P-loop; other site 698758007613 ATP binding site [chemical binding]; other site 698758007614 Q-loop/lid; other site 698758007615 ABC transporter signature motif; other site 698758007616 Walker B; other site 698758007617 D-loop; other site 698758007618 H-loop/switch region; other site 698758007619 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698758007620 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 698758007621 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 698758007622 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 698758007623 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698758007624 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698758007625 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698758007626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698758007627 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 698758007628 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 698758007629 inhibitor binding site; inhibition site 698758007630 active site 698758007631 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 698758007632 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 698758007633 active site 698758007634 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698758007635 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698758007636 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 698758007637 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698758007638 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698758007639 protein binding site [polypeptide binding]; other site 698758007640 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 698758007641 YycH protein; Region: YycI; pfam09648 698758007642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 698758007643 YycH protein; Region: YycH; pfam07435 698758007644 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 698758007645 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698758007646 dimerization interface [polypeptide binding]; other site 698758007647 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698758007648 putative active site [active] 698758007649 heme pocket [chemical binding]; other site 698758007650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698758007651 dimer interface [polypeptide binding]; other site 698758007652 phosphorylation site [posttranslational modification] 698758007653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698758007654 ATP binding site [chemical binding]; other site 698758007655 Mg2+ binding site [ion binding]; other site 698758007656 G-X-G motif; other site 698758007657 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698758007658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698758007659 active site 698758007660 phosphorylation site [posttranslational modification] 698758007661 intermolecular recognition site; other site 698758007662 dimerization interface [polypeptide binding]; other site 698758007663 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698758007664 DNA binding site [nucleotide binding] 698758007665 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698758007666 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698758007667 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698758007668 G5 domain; Region: G5; pfam07501 698758007669 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698758007670 Peptidase family M23; Region: Peptidase_M23; pfam01551 698758007671 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 698758007672 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698758007673 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 698758007674 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698758007675 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 698758007676 GDP-binding site [chemical binding]; other site 698758007677 ACT binding site; other site 698758007678 IMP binding site; other site 698758007679 replicative DNA helicase; Provisional; Region: PRK05748 698758007680 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 698758007681 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698758007682 Walker A motif; other site 698758007683 ATP binding site [chemical binding]; other site 698758007684 Walker B motif; other site 698758007685 DNA binding loops [nucleotide binding] 698758007686 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 698758007687 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 698758007688 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 698758007689 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 698758007690 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 698758007691 DHH family; Region: DHH; pfam01368 698758007692 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 698758007693 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 698758007694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698758007695 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698758007696 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 698758007697 active site 698758007698 catalytic site [active] 698758007699 metal binding site [ion binding]; metal-binding site 698758007700 dimer interface [polypeptide binding]; other site 698758007701 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 698758007702 multidrug efflux protein; Reviewed; Region: PRK01766 698758007703 cation binding site [ion binding]; other site 698758007704 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 698758007705 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 698758007706 ligand binding site [chemical binding]; other site 698758007707 NAD binding site [chemical binding]; other site 698758007708 dimerization interface [polypeptide binding]; other site 698758007709 catalytic site [active] 698758007710 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 698758007711 putative L-serine binding site [chemical binding]; other site 698758007712 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 698758007713 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 698758007714 SLBB domain; Region: SLBB; pfam10531 698758007715 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 698758007716 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 698758007717 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698758007718 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698758007719 dimer interface [polypeptide binding]; other site 698758007720 ssDNA binding site [nucleotide binding]; other site 698758007721 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698758007722 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 698758007723 GTP-binding protein YchF; Reviewed; Region: PRK09601 698758007724 YchF GTPase; Region: YchF; cd01900 698758007725 G1 box; other site 698758007726 GTP/Mg2+ binding site [chemical binding]; other site 698758007727 Switch I region; other site 698758007728 G2 box; other site 698758007729 Switch II region; other site 698758007730 G3 box; other site 698758007731 G4 box; other site 698758007732 G5 box; other site 698758007733 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 698758007734 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 698758007735 Uncharacterized membrane protein [Function unknown]; Region: COG3949 698758007736 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 698758007737 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 698758007738 ParB-like nuclease domain; Region: ParB; smart00470 698758007739 KorB domain; Region: KorB; pfam08535 698758007740 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698758007741 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698758007742 P-loop; other site 698758007743 Magnesium ion binding site [ion binding]; other site 698758007744 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698758007745 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698758007746 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 698758007747 ParB-like nuclease domain; Region: ParB; smart00470 698758007748 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 698758007749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698758007750 S-adenosylmethionine binding site [chemical binding]; other site 698758007751 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 698758007752 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 698758007753 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 698758007754 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 698758007755 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 698758007756 trmE is a tRNA modification GTPase; Region: trmE; cd04164 698758007757 G1 box; other site 698758007758 GTP/Mg2+ binding site [chemical binding]; other site 698758007759 Switch I region; other site 698758007760 G2 box; other site 698758007761 Switch II region; other site 698758007762 G3 box; other site 698758007763 G4 box; other site 698758007764 G5 box; other site 698758007765 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 698758007766 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 698758007767 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 698758007768 G-X-X-G motif; other site 698758007769 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 698758007770 RxxxH motif; other site 698758007771 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698758007772 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 698758007773 ribonuclease P; Reviewed; Region: rnpA; PRK00499 698758007774 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399